SUGIURA Yukio 杉浦幸雄

Researcher Number	40025698
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2011 – 2014: 同志社女子大学, 薬学部, 教授 2008 – 2010: Doshisha Women's College of Liberal Arts, 薬学部, 特任教授 2007: Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences, Professor 2005 – 2006: 同志社女子大学, 薬学部, 教授 1987 – 2004: Institute for Chemical Pesearch Kyoto University Professor, 化学研究所, 教授 … More 1998 – 1999: 京都大学, 科学研究所, 教授 1998: 京都大学, 化学研究科, 教授 1996: 京都大学, 工学研究科, 教授 1995: 京都大学, 工学研究所, 教授 1986: 京大, 薬学部, 助教授 1986: 京都大学, 薬学部, 助教授 Less
Review Section/Research Field	Principal Investigator 医薬分子機能学 / Drug development chemistry / Chemical pharmacy / Bioorganic chemistry / 無機・錯塩・放射化学 / 広領域 / Physical pharmacy / Living organism molecular science Except Principal Investigator Chemical pharmacy / 触媒・化学プロセス … More / 工業物理化学 / Pathological medical chemistry / Physical pharmacy / 無機・錯塩・放射化学 / 天然物有機化学 / Medical pharmacy / Science and Engineering / Inorganic chemistry / Bioorganic chemistry / 工業物理化学・複合材料 Less
Keywords	Principal Investigator 亜鉛フィンガー / DNA認識 / 転写因子 / DNA切断 / ブレオマイシン / 遺伝子制御 / 分子設計 / Zinc finger / マルチフィンガー / DNA結合 … More / モチーフ / DNA recognition / Transcription factor / 人工リプレッサー / Artificial protein / 人工タンパク質 / DNA bending / DNA湾曲 / アーキテクチャー / Gene target / 遺伝子ターゲット / Artificial repressor / Molecular design / Bleomycin / DNA cleavage / C-1027 / 非ヘム鉄 / タンパク質設計 / 塩基配列特異性 / 転写調節 / エンジイン / ダイナミシン / エスペラミシン / エンジイン化合物 / プタキロサイド / 生物無機化学 / Artificial restriction enzyme / DNA motif / DNAモチーフ / Multifinger / Architecture / Gene regulation / DNA binding / Zinc Finger / 活性酸素 / 人工制限酵素 / 抗癌活性 / 酸素活性化 / 塩基特異性 / 制限酵素 / 人工設計 / 機能変換 / GAGA因子 / タンパク質デザイン / 分子認識 / 金属ペプチド / ターゲティング / 塩基認識 / 核酸認識 / ポルフィリン / ダイネミシン / Electron Spin Resonance / Bioinorganic Chemistry / Cytochrome P-450 / Oxygen Activation / Nitrile Hydratase / Low-spin / Non-heme Iron / メスバウアー / ブレオマイシンー鉄錯体 / 低スピン鉄 / 電子スピン共鳴 / チトクロ-ムP-450 / ニトリル水和酵素 / 低スピン / Metal complex / Non-heme iron / DNA塩基認識 / ブレオマイシン金属錯体 / 金属錯体 / Gene Regulation / GAGA Factor / Library / Protein Design / DNA Recognition / Metallofinger / GAGAファクター / ライブラリー / 金属フィンガー / Base specificity / Multi finger / タンパク質工学 / 遺伝子発現 / リンカー / 人工制御酵素 / Kinetic / 動力学 / Molecular disign / Metal peptide / Binding motif / 結合モチーフ / Functional conversion / Genomu information / Base recognition / ゲノム情報 / Esperamicin / Dynemicin / Enediyne / Radical formation / Antitumor antibiotic / 作用発現機構 / DNA設計 / 抗生物質 / ラジカル発生 / 抗癌抗生物質 / Human Geome / Triple Stranded DNA / Nuclease / DNA Cutting / Artificial Restriction Enzymo / グリシル・グリシル・ヒスチジン / ニッケル錯体 / DNA結合蛋白質 / ヒトゲノム / ヒト・ゲノム / 3本鎖DNA / ヌクレアーゼ / molecular design / DNA conformation / dynemicin / calicheamicin / esperamicin / antitumor activity / enediyne / ビラジカル / カリケミシン / コンホメーション選択的切断 / RNA切断 / フェニレンビラジカル / インターカレーション / 2本鎖同時切断 / チトクロームP-450 / ペルオキシダーゼ / 酸化触媒 / 人工酵素 / 蛋白質 / バイオテクノロジー / 遺伝子 / 亜鉛フィンガー蛋白質 / 生命錯体化学 / 加水分解 / 酵素類似 / 触媒機能 / DNA 切断 / DNA 認識 / マルチフインガー / Zif268 / 人工転写因子 / 長鎖認識 / 遺伝子機能 / リンカー配列 / 人工蛋白質 / 転写制御 / 遺伝子ターゲティング / DNA結合モチーフ / リプレッサー / 金属モチーフ / 多重相互作用 / モデリング / 作用発現 / 2本鎖切断 / クロモプロテイン / DNA / 超分子 / tRNA^<Phe> / ループグアニン / 電子スピン共鳴スペクトル / グアニンカルテット構造 / グアニン特異的認識 / ブレオマイシン-ニッケル(III)錯体 / CC-1065 / 生物活性分子 / エナペラミシン / 抗腫瘍性抗生物質 … More Except Principal Investigator 非ヘム鉄錯体 / ジオキシゲナーゼ / モノオキシゲナーゼ / 核酸 / クロロカテコール / 酵素機能発現 / 芳香環酸素化開裂 / 酸素化酵素 / HIV / カテコール / 糖質 / 精密構造認識 / 動的天然物化学 / ブレオマイシン / DNAの光開裂 / 制ガン作用 / 有機金属共役レドックス / Mo-Feクラスター / 窒素固定酵素モデル / 有機ヘム / 薬物代謝 / 転写因子 / 亜鉛フィンガー / 蛋白質 / カテコールジオキシゲナーゼ / 選択性制御 / 分子認識 / 細胞表層 / 励起分子 / 酵素 / 生体低分子 / DNA切断 / arginine / peptide engineering / translocation / synthetic peptide / signal transduction / アルギニン / 転写調節 / ペプチド工学 / 膜透過ペプチド / 合成ペプチド / 細胞内情報伝達 / Oxygenative Cleavages of Aromatics / Dioxygenases / Monooxygenases / Nonheme Iron Complex / MRSA / PCR / Oxygenases / P-450 model / Pー450モデル / 作用機序の解明 / 機能性分子の合成 / 生物有機化学 / π-カチオンラジカル / 酸素機能発現 / 遺伝子発現制御 / 不活性炭化水素 / 超分子 / 生物活性 / 天然有機化合物 / 芳香環開裂 / 酸素化 / 酵素モデル反応 / 炭化水素の官能基化 / 酸素分子活性化 / 転写因子Spl / 芳香環スタッキング / 分子間相互作用 / 多重相互作用 / コレシストキニン / エスペラミシン / 酸素活性化 / Esperamicin / Opioid receptor / Peptide synthesis / Chiral synthesis / Modified oligonucleotide / Retinoid / Chiral 5-deazaflavin / 生物活性物質 / レセプター / ヒトパンクレオスタチン / 5-デアザフラビン / ペプチヂ合成 / 修飾オリゴフクレオチド / P-450モデル / 面不斉5-デアザフラビン / 不斉合成 / オピオイド受容体 / レチノイド / ペプチド合成 / オリゴヌクレオチド / 5ーデアザフラビン / transcription factor / intracellular protein labeling / タンパク質相互作用 / 光架橋 / 細胞内修飾剤 / transcription foctor / transcription regulation / 核移行 / 薬物送達 / HIV-1 Rev / HIV-1 Tat / タンパク質細胞内導入 / 細胞膜透過ペプチド / Enxyme Model Catalysis / Nonheme Manganese Complex / Electron Transfer / 非ヘムマンガン錯体 / 酵素モデル触媒 / 非ネムマンガン錯体 / 電子伝達 / Development of Oxygenase Function / Chlorocatechols / Catechols / Oxygnases / Quantitative PCR / Homogenous sysem / Automated system / Completely closed system / Hepatitis C virus / Intercalation / 定量性 / 凝集分配型除蛋白剤 / プライマー / IM-PCR / PCR定量 / 非固相 / 自動 / 完全密封型 / C型肝炎ウイルス / インターカレーション / Development of Enzymatic Function / Chlorocatechol / Aromatic Ring Cleavage / Catechol / Dioxyenases / Monooxyenases / Nonheme Complex / oxidases model / Metal complex for enzyme model / Dimethyldithiosemi-carbazone-Cu complex / ^<62>Cu Generator system / ^<62>Zn / elsamicin A - iron complex / Platinum complexes / Antitumor metal complex / 脳血流核医学画像診断薬 / 99m-テクネチウム錯体 / P-450 / フェニルアラニンヒドロキシラ-ゼ / ジチオセミカルバゾン銅錯体 / 脳内SOD様薬剤 / 毒性軽減 / Pー450 / ヒスチジンペプチド-グリシン錯体 / モデル錯体 / オキシダ-ゼモデル / 酵素モデル金属錯体 / ジメチルジチオセミカルバゾン銅錯体 / 脳血流診断薬 / エルサミシンAー鉄錯体 / 白金錯体 / 制癌性金属錯体 / 機能性錯体 / 金属イオンの生理活性 / 生体系モデル錯体 / 金属酵素 / 金属タンパク質 / 配位環境 / 生物無機化学 / 生体系金属イオン / 糖脂質 / 光受容膜 / 生合成 / イソプレノイド / コドン認識 / πーカチオンラジカル / 構造解明 / 薬学会大学人会議 / 薬剤師養成 / 評価ガイドライン / 評価基準 / 評価 / 分野別第三者教育評価 / 6年制薬学教育 / 光触媒反応 / 高周期典型元素化合物 / σ-π共役 / 交差カップリング反応 / 高原子価鉄酸化物 / 金属ナノワイヤー / 分子集合体 / 有機超伝導体 / δ-π共役 / 元素科学 / 酸化物半導体 / ナノ磁性体 / 光触媒 / トリフルオロメチル基 / 含高周期元素芳香族化合物 / スピントロニクス / シグマ共役 / 電子構造・構造物性相関 / 金属-絶縁体相転移 / 有機導電体・超伝導体 / 機能性金属タンパク質 / オリゴチフェン / フラーレン / カルベノイド / Ge : SiO_2 / 9-シラフェナントレン / 高圧合成 / 開口フラーレン / 分子手術 / コンフォメーション / オリゴシラン / DNA湾曲 / 脱ハロゲン / 分子集合 / エノラート / Simmons-Smith反応 / 希原子価有機金属 / 核酸認識 / 有機銅化合物 / 遷移金属触媒 / 密度汎関数法計算 / リポキシゲナーゼ / a-ケト依存型ジオキシゲナーゼ / 酸素化酸素 / DNA融解温度 / 遺伝子プロモーター領域 / 抗HIV活性 / 核酸塩基 / 亜鉛 / Zn-フィンガー / 生体金属 / 人工β-cヌクレオチド / RNAポリメラーゼ / TATAボックス / プロモーターDNA / 塩基配列認識 / Znフィンガー / 亜鉛錯体 / DNaseI / 大環状ポリアミン / 脂質 / DNA / 構造認識 / Z型DNA / ニッケル(III) / 生体内酸素化 / 選択性制御機構 / 酵素類似機能発現 / 酸素酸化反応 / 非ヘム鉄酵素 / 不活性炭化水素活性化 / 酵素類似反応 / 酸素化反応 / 単核非ヘム鉄錯体 / アミン酸化酵素 / 白金ブルー錯体 / エチレンレセプター / 神経成長因子 / アルツハイマー病 / 転写因子Sp1 / プテリン補酵素 / キサンチン酸化酵素 / 電子移動反応 / 人工細胞 / 生理活性化合物 / 生物発光 / 亜硝酸還元酵素 / 白金ブル-錯体 / 銅(I)錯体 / エチレンレセプタ- / 癌細胞認識分子 / ドラッグデザイン / インタ-カレ-ション / 抗生物質 / アルツハイマ-型痴呆 / 複合系の分子機能 / 0ージメチルホスフィニル基 / レクチン / 癌細胞障害性マクロファ-ジ / ジメチルホスフィニル基 / シアロシルグリセロリピド / T細胞 Less

Specific DNA Recognition by Fluctuation of Zinc Finger Protein and Development for Smart Transcription FactorPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Doshisha Women's College of Liberal Arts
Creation of First Enzyme-Type Zinc Finger Protein PossessingCatalytic FunctionPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  Doshisha Women's College of Liberal Arts
Creation and Pharmaceutical Development of Intelligent Zinc Fingers Based on Genomic ChemistryPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Doshisha Women's College of Liberal Arts
薬剤師養成を目的とした大学教育に対する外部評価システムの構築のための基盤研究
- Principal Investigator
  
  井上圭三
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Creation of New Functional Artificial Metallofingers : Construction of Library and Development to Gene RegulationPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Doshisha Women's College of Liberal Arts
世界最長のマルチ亜鉛フィンガーの創製と新機能Principal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Doshisha Women's College of Liberal Arts
  Kyoto University
Design and intracellular delivery of peptides for transcription regulation
- Principal Investigator
  
  FUTAKI Shiroh
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
Role of multi zinc finger in gene and creation of its architecturePrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kyoto University
Regulation of cellular genetic function by new DNA bending fingersPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO UNIVERSITY
亜鉛フィンガーモチーフによるDNA認識と遺伝子ターゲティングPrincipal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
転写制御系で働く新規亜鉛フィンガーペプチド
- Principal Investigator
  
  永岡真
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
元素科学:元素の特性を活かした有機・無機構造体の構築
- Principal Investigator
  
  玉尾皓平
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for COE Research
- Research Institution
  Kyoto University
Architectures of Transcriptional Regulation : Creation and Functional Analysis of Multi-Zinc FingersPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO UNIVERSITY
Design and intracellular delivery of peptides for transcription regulation
- Principal Investigator
  
  FUTAKI Shiroh
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
Development or order-mede type artificial restriction enzymes and artificial repressersPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
生体金属による遺伝子発現制御
- Principal Investigator
  
  木村栄一 (木村榮一)
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hiroshima University
新反応系の合理的設計
- Principal Investigator
  
  中村栄一
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
亜鉛フィンガーモチーフによるDNA認識と遺伝子ターゲティングPrincipal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
DNA・RNAを認識する新しい金属フィンガーペプチドの創製Principal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University
亜鉛フィンガーモチーフによるDNA認識と遺伝子ターゲティングPrincipal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
Creation and Function of Novel Gene Regulation Molecules Based on Zinc Finger MotifPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO UNIVERSITY
酸素化酸素機能を発現する非ヘム鉄錯体触媒の設計
- Principal Investigator
  
  船引卓三
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
脱ハロゲン酸素化酵素機能を発現する金属錯体の分子設計
- Principal Investigator
  
  船引卓三
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Inorganic chemistry
- Research Institution
  Kyoto University
核酸を認識する新しい金属モチーフの創製Principal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto University
Development ot highly selective oxygenation by oxygenase-model metal-oxygen active species and clarification of the mechanisms of selectivity control
- Principal Investigator
  
  FUNABIKI Takuzo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  触媒・化学プロセス
- Research Institution
  KYOTO UNIVERSITY
Development of multicompont systems of metal complexes/molecular oxygen/electron Transfer that function oxygenale-like catalytic activity
- Principal Investigator
  
  FUNABIKI Takuzo
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  工業物理化学
- Research Institution
  Kyoto University
Functional Conversion and Artificial Repressor of Zinc Finger ProteinsPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO UNIVERSITY
非ヘム鉄錯体による酸素分子の活性化と炭化水素の選択的官能基化
- Principal Investigator
  
  船引卓三
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Action mechanism and molecular design of biologically active enediyne compoundsPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  KYOTO UNIVERSITY
Development of selective oxygenation of nonactivated hydrocarbons by iron catalysts
- Principal Investigator
  
  FUNABIKI Takuzo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  触媒・化学プロセス
- Research Institution
  KYOTO UNIVERSITY
Development of automated PCR monitoring system
- Principal Investigator
  
  UEDA Kunihiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KYOTO UNIVERSITY
非ヘム鉄錯体による酸素分子の活性化と炭化水素の選択的官能基化
- Principal Investigator
  
  船引卓三
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
有機ニッケル(III)錯体の創製とそのグアニン特異的認識能の応用
- Principal Investigator
  
  OTSUKA Masami
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
DNAの関与する超分子形成と機能Principal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
天然超分子化学の総合的研究
- Principal Investigator
  
  楠本正一
- Project Period (FY)
  1994 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
動的天然物化学の総合的研究
- Principal Investigator
  
  小倉協三
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
生体関連金属錯体における多重相互作用と機能発現の研究
- Principal Investigator
  
  山内脩
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
非ヘム鉄錯体による酸素分子の活性化と炭化水素の選択的官能基化
- Principal Investigator
  
  船引卓三
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
有機ニッケル(III)錯体の創製とそのグアニン特異的認識能の応用Principal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
天然超分子の化学的研究
- Principal Investigator
  
  楠本正一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Osaka University
非ヘム鉄酵素モデル錯体による生体内酸素化反応の機能発現と選択性制御機構の解明
- Principal Investigator
  
  船引卓三
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto University
Chemical Creation of Artificial Restriction Enzyme and Its Application to Genomic AnalysisPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO UNIVERSITY
単核非ヘム鉄錯体/酸素系による酵素類似選択的酸素化反応の開発研究
- Principal Investigator
  
  FUNABIKI Takuzo
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  工業物理化学・複合材料
- Research Institution
  Kyoto University
新規エンジイン化合物の活性発現制御と分子設計Principal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
複合系の分子機能
- Principal Investigator
  
  植木正彬
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Science
動的天然物化学の総合的研究
- Principal Investigator
  
  小倉協三
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
生物活性分子による核酸の精密構造認識と機能発現Principal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
生体関連金属錯体における多重相互作用と機能発現の研究
- Principal Investigator
  
  山内脩
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
動的天然物化学の総合的研究
- Principal Investigator
  
  小倉協三
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
生物活性分子による核酸の精密構造認識と機能発現Principal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
生物活性分子による核酸の精密構造認識と機能発現Principal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
複合系の分子機能
- Principal Investigator
  
  大野雅二
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
複合系の分子機能
- Principal Investigator
  
  大野雅二
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Pharmacological Studies on Bio-active Metal Complexes
- Principal Investigator
  
  YAMANE Yasuhiro
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
分子認識を目指す動的天然物化学
- Principal Investigator
  
  後藤俊夫
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  天然物有機化学
- Research Institution
  Nagoya University
生体系金属イオンの配位環境と生理活性
- Principal Investigator
  
  山内脩
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  無機・錯塩・放射化学
- Research Institution
  Nagoya University
高い酸素活性化能を有する新規な非ヘム鉄錯体の開発とその酸化触媒としての応用Principal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Bioinorganic Chemistry on Structure and Function of Unprecented Low-Spin Typed Non-Heme Iron(III) ComplexesPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  無機・錯塩・放射化学
- Research Institution
  KYOTO UNIVERSITY
人工DNA制限酵素の設計と機能解析Principal Investigator
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto University
New Frontier in Bioorganic Chemistry Research
- Principal Investigator
  
  YONEDA Fumio
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University
生体機能を有する有機金属化合物
- Principal Investigator
  
  生越久靖
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Nagaoka University of Technology
ニューフロンティア生物有機化学の基礎的研究
- Principal Investigator
  
  YONEDA Fumio
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University
生体機能を有する有機金属化合物
- Principal Investigator
  
  生越久靖
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Nagaoka University of Technology
生体機能を有する有機金属化合物
- Principal Investigator
  
  生越久靖
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto University
Bioinorganic study on bleomycin-transition metal complexes possessing DNA cleavage activityPrincipal Investigator
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  Kyoto University

All 2015 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] Engineered Zinc Figer Proteins(Eds.by J.P.Mackey, D.J.Segal)(Non-FolkI-based zinc finger nucleases)2010
- Author(s)
  M.Imanishi, S.Negi, Y.Sugiura
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Supramolecular intracellular delivery of an anionic porphyrin by octaarginine-conjugated per-O-methyl-β-cyclodextrin2015
- Author(s)
  H.Kitagisshi, F.Chai, S.Negi. Y.Sugiuraand K.Kano
- Journal Title
  
  Chem.Commun.
  
  Volume: 51 Issue: 12 Pages: 2421-2424
- DOI
  10.1039/c4cc09042j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390012, KAKENHI-PROJECT-26350962, KAKENHI-PROJECT-26870704
[Journal Article] Zn(II) binding and DNA binding properties of ligand-substituted XXHH-type zinc finger proteins2012
- Author(s)
  M.Imanishi, K.Matsumura, S.Tsuji, T.Nakaya, S.Negi, S.Futaki, Y.Sugiura
- Journal Title
  
  Biochemistry
  
  Volume: 51(16) Pages: 3342-3348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] New functions of zinc fingers revealed by substitution of conserved residues, Zinc Fingers:Struc-ture, Properties and Functions, Ed. By S.Gonzalez2012
- Author(s)
  M.Imanishi, Y.Sugiura
- Journal Title
  
  NovaScience Publishers
  
  Pages: 141-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] Rational design of DNA sequencespecific zinc fingers2012
- Author(s)
  H.Kono, M.Imanishi, S.Negi, K.Tatsutani, T.Sakaeda, A.Hashimoto, C.Nakayama, S.Futaki, Y.Sugiura
- Journal Title
  
  FEBS Lett
  
  Volume: 586(6) Pages: 918-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] An arginine residue instead of a conserved leucine residue in the recognition helix of the finger 3 of Zif268 stabilizes the domein structure and mediates DNA binding2011
- Author(s)
  S.Negi, M.Imanishi, M.Sasaki, K.Tatsutani, S.Futaki, Y.Sugiura
- Journal Title
  
  Biochemistry
  
  Volume: 50(28) Pages: 6366-6372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] Metal-stimulated transcriptional regulation by an artificial zinc fingerprotein2010
- Author(s)
  M.Imanishi, T.Nakaya, T.Morisaki, D.Noshiro, S.Futaki, Y.Sugiura
- Journal Title
  
  ChemBioChem
  
  Volume: 11(12) Pages: 1653-1655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] Metal-stimulated transcriptional regulation by an aritificial zinc finger protein2010
- Author(s)
  M.Imanishi, T.Nakaya, T.Morisaki, D.Noshiro, S.Futaki, Y.Sugiura
- Journal Title
  
  ChemBioChem 11(12)
  
  Pages: 1653-1655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Sp12010
- Author(s)
  M.Imanishi, C.Imamura, C.Hogashi, W.Yan, S.Negi, S.Futaki, Y.Sugiura
- Journal Title
  
  Biochem.Biophys.Res.Commun
  
  Volume: 400(4) Pages: 625-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] Non-FolkI-based zinc finger nucleases, Engineered Zinc Finger Proteins, Ed. by J.Markay & D.Segal2010
- Author(s)
  M.Imanishi, S.Negi, Y.Sugiura
- Journal Title
  
  Methods in Molecular Biology
  
  Pages: 337-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] マルチ亜鉛フィンガー型人工転写因子の創製と機能2010
- Author(s)
  森崎達也、今西未来、二木史朗、杉浦幸雄
- Journal Title
  
  薬学雑誌 130(1)
  
  Pages: 45-48
- NAID
  130000152009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Spl2010
- Author(s)
  M.Imanishi, C.Imamura, C.Higashi, W.Yan, S.Negi, S.Futaki, Y.Sugiura
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 400(4) Pages: 625-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Spl, Biochem.Biophys.2010
- Author(s)
  M.Imanishi, C.Imamura, C.Higashi, W.Yan, S.Negi, S.Futaki, Y.Sugiura
- Journal Title
  
  Res.Commun. 400(4)
  
  Pages: 625-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Novel zinc finger nuclease created by combining the Cys_2His_2 and His_4 type zinc finger domain2009
- Author(s)
  S.Negi, Y.Umeda, S.Masuyama, Y.Sugiura
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19(10)
  
  Pages: 2789-2791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Novel redesigned zinc finger proteins : Design strategy and its application2008
- Author(s)
  S.Negi, M.Imanishi, M.Matsumoto, Y.Sugiura
- Journal Title
  
  Chem.Eur.J. 14(11)
  
  Pages: 3236-3249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Rapid transcriptional activity in vivo and slow DNA binding in vitro by artificial multi-zinc finger protein2008
- Author(s)
  T.Morisaki, M.Imanishi, S.Futaki, Y.Sugiura
- Journal Title
  
  Biochemistry 47(38)
  
  Pages: 10171-10177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Effects of bulkiness and hydrophobicity of aliphatic amino acid at recognition helix of GAGA zinc finger on the stability of hydrophobic core and DNA-binding affinity2008
- Author(s)
  M.Dhanasekaran, S.Negi, M.Imanishi, M.Suzuki, Y.Sugiura
- Journal Title
  
  Biochemistry 47(45)
  
  Pages: 11717-11724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Presentation] GAGA metallo finger peptides: Its metal-binding, DNA-binding and redox propertses2013
- Author(s)
  S.Negi and Y.Sugiura
- Organizer
  XVI International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Grenoble, France
- Data Source
  KAKENHI-PROJECT-24390012
[Presentation] 亜鉛フィンガータンパク質のレドックス挙動2012
- Author(s)
  根木滋、山岡槇子、福田あずさ、杉浦幸雄
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  横浜市
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] 人工亜鉛フィンガータンパク質のデザインおよびその機能2011
- Author(s)
  根木滋、谷口仁哉、杉浦幸雄
- Organizer
  第36回生体分子科学討論会
- Place of Presentation
  札幌市
- Year and Date
  2011-06-19
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] 配位子置換亜鉛フィンガータンパク質のDNA結合特性2011
- Author(s)
  今西未来、中尾智博、松林一央、二木史朗、杉浦幸雄
- Organizer
  第24回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  千葉市
- Year and Date
  2011-05-31
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] GAGA亜鉛フィンガータンパク質の酸化に伴う構造および機能変化2011
- Author(s)
  根木滋、増山紗永子、山岡槇子、杉浦幸雄
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  横浜市
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] 新規GAGA金属置換型フィンガーの創製およびその機能評価2011
- Author(s)
  増山紗永子、根木滋、野口範子、杉浦幸雄
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  横浜市
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] リデザインによる野生型亜鉛フィンガー蛋白質の機能変換2010
- Author(s)
  根木滋、三間紘子、杉浦幸雄
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌市
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] リデザインによる野生型亜鉛フィンガータンパク質の機能改変:人工亜鉛フィンガー型ヌクレアーゼの創生2010
- Author(s)
  根木滋、三間紘子、杉浦幸雄
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌市
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-20390037
[Presentation] 亜鉛濃度に応答した亜鉛フィンガー転写因子の創製2010
- Author(s)
  中屋智博、今西未来、森崎達也、能代大輔、二木史朗、杉浦幸雄
- Organizer
  第20回金属が関与する生体関連反応シンポジウム
- Place of Presentation
  徳島市
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-20390037
[Presentation] インテリジェント人工亜鉛フィンガー蛋白質の創製と医学・薬学領域への展開2010
- Author(s)
  杉浦幸雄
- Organizer
  日本薬学会東海支部特別講演会
- Place of Presentation
  名古屋市
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-20390037
[Presentation] マルチ亜鉛フィンガー型人工転写因子の創製と機能2009
- Author(s)
  森崎達也、今西未来、二木史朗、杉浦幸雄
- Organizer
  第129回日本薬学会
- Place of Presentation
  京都市
- Year and Date
  2009-03-10
- Data Source
  KAKENHI-PROJECT-20390037
[Presentation] 生体と金属-生体に不可欠な元素-2009
- Author(s)
  杉浦幸雄
- Organizer
  第14回国際生物無機化学会議公開市民講座
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-20390037
[Presentation] 生体と金属:生体に不可欠な元素2009
- Author(s)
  杉浦幸雄
- Organizer
  第14回国際生物無機化学会議(公開市民講座)
- Place of Presentation
  名古屋市
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-20390037
[Presentation] 新機能性人工亜鉛フィンガー蛋白質の設計2008
- Author(s)
  杉浦幸雄
- Organizer
  第8回蛋白質科学会年会
- Place of Presentation
  タワーホール船橋(東京)
- Year and Date
  2008-06-10
- Data Source
  KAKENHI-PROJECT-20390037
[Presentation] 新機能性人工亜鉛フィンガータンパク質の設計2008
- Author(s)
  杉浦幸雄
- Organizer
  第8回日本蛋白質科学会
- Place of Presentation
  東京都
- Year and Date
  2008-06-18
- Data Source
  KAKENHI-PROJECT-20390037
[Presentation] マルチ亜鉛フィンガーのin vitro及びin celluloでの挙動相関2008
- Author(s)
  森崎達也、今西未来、二木史朗、杉浦幸雄
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸市
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20390037
[Presentation] Creation of artificial zinc finger protein having enzyme activity2007
- Author(s)
  Y. Sugiura
- Organizer
  Symposium on 22nd Biofunctional Related Chemistry
- Place of Presentation
  Sendai
- Year and Date
  2007-09-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390028
[Presentation] 酵素機能を有する人工亜鉛フィンガータンパク質の創製2007
- Author(s)
  杉浦幸雄
- Organizer
  第22回生体機能関連化学シンポジウム
- Place of Presentation
  仙台市
- Year and Date
  2007-09-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390028
[Presentation] Sp1亜鉛フィンガーの各フィンガードメインにおけるレドックス応答の非対称性
- Author(s)
  根木滋、福田あずさ、鎌手裕実香、杉浦幸雄
- Organizer
  第41回生体分子科学討論会
- Place of Presentation
  九州大学西新プラザ、福岡市
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24390012

1. TAKANO Mikio (70068138)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
2. FUNABIKI Takuzo (70026061)

# of Collaborated Projects: 10 results

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SUGIURA Yukio 杉浦 幸雄

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Specific DNA Recognition by Fluctuation of Zinc Finger Protein and Development for Smart Transcription FactorPrincipal Investigator

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Creation of First Enzyme-Type Zinc Finger Protein PossessingCatalytic FunctionPrincipal Investigator

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Creation and Pharmaceutical Development of Intelligent Zinc Fingers Based on Genomic ChemistryPrincipal Investigator

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Creation of New Functional Artificial Metallofingers : Construction of Library and Development to Gene RegulationPrincipal Investigator

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世界最長のマルチ亜鉛フィンガーの創製と新機能Principal Investigator

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Role of multi zinc finger in gene and creation of its architecturePrincipal Investigator

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Regulation of cellular genetic function by new DNA bending fingersPrincipal Investigator

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亜鉛フィンガーモチーフによるDNA認識と遺伝子ターゲティングPrincipal Investigator

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Architectures of Transcriptional Regulation : Creation and Functional Analysis of Multi-Zinc FingersPrincipal Investigator

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SUGIURA Yukio 杉浦幸雄