MIWA Soichi 三輪聡一

… Alternative Names

MIWA Souiti 三輪聡一

三輪聡ミワソウイチ

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Researcher Number	40157706
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2015: 北海道大学, 大学院医学研究科, 教授 2011 – 2014: 北海道大学, 医学(系)研究科(研究院), 教授 2007 – 2012: Hokkaido University, Graduate School of Medicine, Professor 2006: 北海道大学, 大学院医学研究科, 教授 2000 – 2005: Hokkaido Univ., Grad.School of Med., Prof., 大学院・医学研究科, 教授 … More 2003: 北海道大学, 医学部, 教授 2003: Hokkaido Univ., Grad.School of Medicine, Professor 1999: 京都大学, 医学研究科, 助教授 1995 – 1997: Faculty of Medicine, Kyoto University Associate Professor, 医学研究科, 助教授 1992 – 1994: 京都大学, 医学部, 助教授 1992: 京都大学医学部薬理学教室, 助教授 1989 – 1991: 京都大学, 医学部, 講師 1986 – 1987: 京都大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology / Science and Engineering Except Principal Investigator General pharmacology / General medical chemistry / General pharmacology / Circulatory organs internal medicine / Biological Sciences / 工業分析化学
Keywords	Principal Investigator エンドセリン / エンドセリン受容体 / カルシウムチャンネル / 血管平滑筋 / テトラヒドロビオプテリン / GST pull-down / Ca^<2+> uptake / Vascular smooth muscle cell / cDNAクローニング / カルシウム取り込み … More / アフリカツメガエル卵母細胞 / 収縮 / シクロペンテノン / メチルビニルケトン / Jab1 / ユビキチン化 / 蛋白質分解 / 酵母ツーハイブリッド法 / クローニング / 結合実験 / ドーパミン遊離 / cDNA cloning / yeast two-hybrid / Xenopus oocyte / Ca^<2+> channel / Endothelin receptor / 受容体作動性カルシウムチャネル / _CDNAクローニング / 酵母two-hybrid / カルシウムチャネル / Xenopus oocytes / Expression cloning / Voltage-independent Ca^<2+> channels / Vascular contraction / Endothelin / ショ糖密度勾配超遠心 / ボルテージクランプ / ^<45>Ca^<2+>取り込み / 発現クローニング / 卵母細胞 / 受容体作動性カルシウムチャンネル / CDNAクローニング / 受容体作動性カルシュムチャネル / transient receptor potential / LOE 908 / SK＆F 96365 / store-operated Ca^<2+> channel / nonselective cation channels / vascular smooth muscle cell / endothelin-1 / カルシウム / ストア作動性カルシウムチャンネル / trp / LOE908 / SK＆F96365 / ストア作動性Ca^<2+>チャンネル / 非選択的陽イオンチャンネル / カルボニル化 / アクロレイン / 不飽和カルボニル化合物 / タバコ煙ガス相 / 2型糖尿病 / Gタンパク質共役型受容体結合タンパク質 / Gタンパク質共役型受容体 / インスリン / Gタンパク質共役型受容体キナーゼ2 / 骨格筋 / エンドセリン-1 / 薬理学 / 活性酸素種 / NADPHオキシダーゼ / プロテインキナーゼC / タバコ煙水抽出液 / 動脈硬化 / 細胞分化 / マクロファージ / カルボニル化合物 / タバコ煙水抽出物 / 喫煙 / PKC / 細胞傷害 / タバコ煙 / リン酸化 / 細胞内移行 / ユビキチン / trafficking / タンパク質分解 / 受容体結合タンパク質 / タンパク質間相互作用 / 蛋白質間相互作用 / エンドセリンA型受容体 / Jab 1 / チトクロームP450 / 内皮由来弛緩因子 / 血管平滑筋細胞 / 血管内皮細胞 / コネキシン / ラット腸管膜動脈 / ギャップジャンクション / Kチャネル / 内皮由来過分極因子 / 一酸化窒素合成酵素 / 結合蛋白質 / ビオプテリン / パッチクランプ / 細胞内遊離カルシウム濃度 / イオンチャンネル / スライスパッチ法 / 透析法 / 微小脳 / セピアプテリン / テトラヒドロビオプテリン受容体 / ド-パミン遊離 … More Except Principal Investigator エンドセリン / エンドセリン受容体 / エンドセリン変換酵素 / endothelin receptor / endothelin / 国際エンドセリン会議 / 国際薬理学連合受容体委員会 / エンドセリン受容体拮抗薬 / 内皮細胞 / 一酸化窒素 / endothelin converting enzyme / 非選択的カチオンチャネル / Gタンパク質共役受容体 / ユビキチン化 / リサイクリング / エンドサイトーシス / ユビキチン / Endothelium-dependent contraction / Cerebrospinal fluid / Subarachnoid hemorrhage / 脳血管 / 脳脊髄液 / TX【A_2】様物質 / 内皮細胞依存性収縮因子 / クモ膜下出血 / 脳血管攣縮 / TXA2-様物質 / 内皮細胞由来血管収縮物質 / 脳血管〓縮物質 / Heart failure / Hypertension / Cardiovascular diseases / Oxidative stress / Mitochondrial DNA / Genes / Transcription factor / Mitochondria / 循環器・高血圧 / 細胞・組織 / 内科 / 糖尿病 / 心不全 / 高血圧 / 心血管病 / 酸化ストレス / ミトコンドリアDNA / 遺伝子 / 転写因子 / ミトコンドリア / quinolinic acid / post-translational modification / excitatory neurotoxin / INF-γ / knockout mouse / Alzheimer's disease / Kynurenylation / tryptophan metabolism / 分子生物学 / 翻訳後蛋白修飾 / 感染防御機構 / 翻訳語蛋白修飾 / 興奮性神経毒 / インターフェロンガンマ / ノックアウトマウス / アルツハイマー病 / キヌレニン化 / トリプトファン代謝 / connexin / gap junction / ion channel / relaxation / artery / smooth muscle cell / endothelial cell / EDHF / カリウムイオンチャンネル / コネキシン / ギャップジャンクション / イオンチャネル / 弛緩因子 / 血管 / 平滑筋細胞 / 内皮由来過分極因子 / Endothelin antagonist / Endothelium / IUPHA / Endothelin receptor / Endothelin / エンドセリ / International Conference on Endothelin / International Union of Pharmacological Sciences / Receptor Nomenclature and Drug Classification Committee / endothelin receptor antagonist / cell growth, dystroglycan / vasoconstriction / oxidized LDL / nitric oxide / vascular endothelium / カチオンチャネル / 非選択的陽イオンチャネル / 電位依存性カルシウムチャネル / 変成LDL受容体 / 受容体輸送活性相関 / アルギニン輸送体 / 変性LDL受容体 / ジストログリカン / 酸化LDL / 細胞増殖 / 血管収縮 / 血管内皮 / endothelin antagonist / conference on endothelin / international receptor committee / 受容体拮抗薬 / 薬物受容体 / Brain ischemia model / Schizophrenia / Infantile antism / Glutamate system / Dopamine D_2 receptor / Dopamine turnover / Dopaminergic system / Positron emission tomography / 睡眠-覚醒 / 麻酔 / イオンチャンネル / ベンゾジアゼピン受容体 / ムスカリン性アセチルコリン受容体 / ^<11>C-5-ヒドロキシトリプトファン / ^<11>C-ドーバ / ペンゾジアゼピン系 / GABA系 / アセチルコリン系 / 麻酔剤 / ポジトロンエミッショントモグラフィー / 脳虚血モデル / 精神分裂症 / 小児自閉症 / グルタミン酸系 / ドーパミンD2受容体 / ドーパミン代謝回転 / ドーパミン系 / ホジトロンエミッショントモグラフィー / in vivo Analysis / Voltammetry / Learning machine / Random pulse / Carbonfiberelectrode / Dopamine / Neurotransmitter / ボルタンメトリ- / ド-パミン / 生体応用 / ボルタンメトリ / 学習機械 / ランダムパルス / 炭素繊維電極 / ドーパミン / 神経伝達物質 / 受容体作動性Caチャンネル / 脈動脈 / ROC / VOC / 内皮細胞由来TX【A_2】様物質 / 内皮細依存性収縮 / 脳血管スパスム / ビッグエンドセリン / 金属プロテアーゼ / カルシウム拮抗薬 / メフェナム酸 / カルシウムインフラックス / カルシウム / G蛋白質 / カルシウムチャネル / カルシウムチャンネル / ニコチン受容体 / カルシウムイオン / カテコ-ルアミン / クロマフィン細胞 / 交感神経 / 低酸素 Less

タバコ煙中低分子化合物による細胞傷害メカニズムの解明と無毒化タバコ作製の試みPrincipal Investigator
- Principal Investigator
  
  三輪聡一
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Hokkaido University
Molecular mechanism of trafficking regulation of G protein-coupled receptor
- Principal Investigator
  
  Terada Koji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Shiga University of Medical Science
  Hokkaido University
エンドセリン受容体結合蛋白質によるシグナルソーム形成を介した２型糖尿病発症機序Principal Investigator
- Principal Investigator
  
  三輪聡一
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hokkaido University
Elucidation of molecular mechanism of cell damage by cigarette smoke extract and development of cigarette smoke detoxification methodsPrincipal Investigator
- Principal Investigator
  
  MIWA Soichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Hokkaido University
Study of the regulatory mechanism of ETAR and ETBR level by receptor binding protein and the relevance between clinical significance and endothelin receptor level.Principal Investigator
- Principal Investigator
  
  MIWA Soichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hokkaido University
Search for novel signal molecules which are directly activated by endothelin receptorPrincipal Investigator
- Principal Investigator
  
  MIWA Soichi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hokkaido University
Analysis of the role of mitochondrial transcription factor in cardiovascular diseases and the development of novel therapeutic strategies
- Principal Investigator
  
  TSUTSUI Hiroyuki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hokkaido University
Structure and function of receptor-operated Ca^<2+> channels and development of specific blockers of the channelsPrincipal Investigator
- Principal Investigator
  
  MIWA Soichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  HOKKAIDO UNIVERSITY
Cloning and functional analysis of the genes related to endothelium derived hyperpolarizing factor
- Principal Investigator
  
  FUAKO Mitsuhiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  SAPPORO MEDICAL UNIVERSITY
  Hokkaido University
Generation of indoleamine 2,3-dioxygenase-dificient mouse
- Principal Investigator
  
  TAKIKAWA Osamu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  HOKKAIDO UNIVERSITY
内皮由来過分極因子の分離・同定・機能解析Principal Investigator
- Principal Investigator
  
  三輪聡一
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
The structure and function of voltage-independent Ca^<2+> channels involved in vascular contractionsPrincipal Investigator
- Principal Investigator
  
  MIWA Soichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hokkaido University
The structure and function of Ca^<2+>-permeable nonselective cation channelsPrincipal Investigator
- Principal Investigator
  
  MIWA Soichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hokkaido University
  Kyoto University
Pharmacology
- Principal Investigator
  
  MASAKI Tomoh
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General pharmacology
- Research Institution
  National Cardiovascular Center Research Institute
Pharmacology of endothelin and endothelin receptor
- Principal Investigator
  
  MASAKI Tomoh
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
Study on the regulatory mechanisms of endothelium-dependent vasoconstriction and growth of vascular cells
- Principal Investigator
  
  MASAKI Tomoh
- Project Period (FY)
  1995 – 1998
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  National Cardiovascular Center Research Institute
  Kyoto University
新しい循環調節薬としてのエンドセリン変換酵素抑制薬開発のための研究
- Principal Investigator
  
  真崎知生, 眞崎知生
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
バイオプテリン結合活性をもつ新しい機能蛋白質群のcDNAクローニングPrincipal Investigator
- Principal Investigator
  
  三輪聡一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
Pharmacology of endothelin receptor and its agonist/antagonist
- Principal Investigator
  
  MISAKI Tomoh, 真崎知生
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
エンドセリン誘発収縮に関与する新しい因子の検索とそのクローニング
- Principal Investigator
  
  真崎知生, MISAKI Tomoh
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
テトラヒドロビオプテリン受容体のクローニング及びその機能解析Principal Investigator
- Principal Investigator
  
  三輪聡一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
6R-テトラヒドロビロビオプテリンによる神経伝達物質放出の調節機構Principal Investigator
- Principal Investigator
  
  三輪聡一
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Turnover of neurotransmitters in the living and functional brain analized by positron emission Tomography
- Principal Investigator
  
  WATANABE Yasuyoshi, 渡邊恭良
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka Bioscience Institute
テトラヒドロビオプテリン受容体の構造及び機能の解明Principal Investigator
- Principal Investigator
  
  三輪聡一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
低酸素環境下における血管系の神経情報変換・伝達機構
- Principal Investigator
  
  FUJIWARA Motohatsu
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
in vivo Analysis of Dopamine in rat brain using voltammetry with randompulse signal
- Principal Investigator
  
  ICHISE Mitsunojo
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  工業分析化学
- Research Institution
  KYOTO UNIVERSITY
血管スパスムにおけるCaイオン動態と役割:受容体作動性Caイオンチャンネル
- Principal Investigator
  
  藤原元始
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto University
ヒト脳血管スパスムにおけるCaイオンの動態と役割
- Principal Investigator
  
  藤原元始
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto University
Expoloration of spasmogenic factors and its antagonist for cerebrovasculor spasm
- Principal Investigator
  
  FUJIWARA Motohatsu
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University

All 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] 臨床分子内分泌学(1)-心血管内分泌代謝系(上)- v.エンドセリン薬理作用と生理作用血管作用2004
- Author(s)
  三輪聡一
- Total Pages
  744
- Publisher
  日本臨牀
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390075
[Book] 臨床分子内分泌学(1)-心血管内分泌代謝系(上)- v.エンドセリン薬理作用と生理作用マクロファージ作用2004
- Author(s)
  三輪聡一
- Total Pages
  744
- Publisher
  日本臨牀
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390075
[Journal Article] Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells2016
- Author(s)
  Horinouchi T, Hoshi A, Harada T, Higa T, Karki S, Terada T, Higashi T, Mai Y, Nepal P, Mazaki Y, Miwa S
- Journal Title
  
  Br J Pharmacol
  
  Volume: 173 Issue: 6 Pages: 1018-1032
- DOI
  10.1111/bph.13406
- NAID
  120005981358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860166, KAKENHI-PROJECT-25460326
[Journal Article] Agonist-promoted ubiquitination differentially regulates receptor trafficking of endothelin type A and type B receptors.2014
- Author(s)
  Terada K., Horinouchi T., Fujioka Y., Higashi T., Nepal P., Horiguchi M., Sarita K., Hatate C., Hoshi A., Harada T., Mai Y., Ohba Y. and Miwa S.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Issue: 51 Pages: 35283-35295
- DOI
  10.1074/jbc.m113.544171
- NAID
  120005549588
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460326, KAKENHI-PROJECT-25670184, KAKENHI-PUBLICLY-26115701, KAKENHI-PROJECT-26293041, KAKENHI-PROJECT-26860166, KAKENHI-PROJECT-26860254
[Journal Article] A simple and rapid method for standard preparation of gas phase extract of cigarette smoke.2014
- Author(s)
  Higashi T., Mai Y., Noya Y., Horinouchi T., Terada K., Hoshi A., Nepal P., Harada T., Horiguchi M., Hatate C., Kuge Y. and Miwa S.
- Journal Title
  
  PLos ONE
  
  Volume: 9 Issue: 9 Pages: e107856-e107856
- DOI
  10.1371/journal.pone.0107856
- NAID
  120005496512
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460326, KAKENHI-PROJECT-26860166
[Journal Article] Endothelin-1 activates extracellular signal-regulated kinases 1/2 via transactivation of platelet-derived growth factor receptor in rat L6 myoblasts.2014
- Author(s)
  Harada T, Horinouchi T, Higa T, Hoshi A, Higashi T, Terada K, Mai Y, Nepal P, Horiguchi M, Hatate C, Miwa S.
- Journal Title
  
  Life Sci.
  
  Volume: 104 Issue: 1-2 Pages: 24-31
- DOI
  10.1016/j.lfs.2014.04.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390059, KAKENHI-PROJECT-25460326, KAKENHI-PROJECT-26860166
[Journal Article] Identification of stable cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological characterization of their cytotoxicity.2013
- Author(s)
  Noya Y, Seki K, Asano H, Mai Y, Horinouchi T, Higashi T, Terada K, Hatate C, Hoshi A, Nepal P, Horiguchi M, Kuge Y, Miwa S.
- Journal Title
  
  Toxicology
  
  Volume: 314 Issue: 1 Pages: 1-10
- DOI
  10.1016/j.tox.2013.08.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390059, KAKENHI-PROJECT-25460326, KAKENHI-PROJECT-25670123
[Journal Article] Endothelin receptor signaling: new insight into its regulatory mechanisms.2013
- Author(s)
  Horinouchi T, Terada K, Higashi T, Miwa S.
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 123 Pages: 85-101
- NAID
  130003382599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390059
[Journal Article] Endothelin receptor signaling: new insight into its regulatory mechanisms2013
- Author(s)
  Harada T., Horinouchi T., Higa T., Hoshi A., Higashi T., Terada K., Mai Y., Nepal P., Horiguchi M., Hatate C. and Miwa S.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 123 Pages: 85-101
- NAID
  130003382599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460326
[Journal Article] Endothelin receptor signaling: new insight into its regulatory mechanisms2013
- Author(s)
  Horinouchi T, Terada K, Higash T, Miwa S
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 123 Pages: 85-101
- NAID
  130003382599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670123
[Journal Article] Different binding property of STIM1 and its novel splice variant STIM1L to Orai1, TRPC3, and TRPC6 channels2012
- Author(s)
  Horinouchi T, Higashi T, Higa T, Terada K, Mai Y, Aoyagi H, Hatate C, Nepal P, Harada T, Miwa S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 428 Pages: 252-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659129
[Journal Article] Function and regulation of endothelin type A receptor-operated TRPC channels2012
- Author(s)
  Horinouchi T., Terada K., Higa T., Aoyagi H., Nishiya T., Suzuki H. and Miwa S.
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 340 Pages: 143-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Nicotine-and tar-free cigarette smoke induces cell damage through reactive oxugen species newly generated by PKC-dependent activation of NADPH oxidase2012
- Author(s)
  Asano H, Horinouchi T, Mai Y, Sawada O, Fujii S, Nishiya T, Minami M, Katayama T, Iwanaga T, Terada K, Miwa S
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 118 Pages: 275-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659129
[Journal Article] Nicotine-and tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase2012
- Author(s)
  Asano H., Horinouchi T., Mai Y., Sawada O., Fujii S., Nishiya T., Minami M., Katayama T., Iwanaga T., Terada K. and Miwa S.
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 118 Pages: 275-287
- NAID
  10030455160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Adenylate cyclase/cAMP/protein kinase A signaling pathway inhibits endothelin type A receptor-operated Ca2+ entry mediated via transient receptor potential canonical 6 channels2012
- Author(s)
  Horinouchi T, Higa T, Aoyagi H, Nishiya T, Terada K, Miwa S
- Journal Title
  
  Pharmacol Exp Ther
  
  Volume: 340 Pages: 143-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659129
[Journal Article] Adenylate cyclase-cAMP-protein kinase A signaling pathway inhibits endothelin type A receptor-operated Ca2+ entry mediated via TRPC6 channels2012
- Author(s)
  Horinouchi T., Higa T., Aoyagi H., Nishiya T., Terada K. and Miwa S.
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 340 Pages: 143-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Adenylate cyclase-cAMP-protein kinase A signaling pathway inhibits endothelin type A receptor-operated Ca2+ entry mediated via TRPC6 channels2012
- Author(s)
  Horinouchi T, Higa T, Aoyagi H, Nishiya T, Terada K, Miwa S
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 340(1) Issue: 1 Pages: 143-151
- DOI
  10.1124/jpet.111.187500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590066, KAKENHI-PROJECT-24390059, KAKENHI-PROJECT-24590309
[Journal Article] Nicotine- and tar-free cigarette smoke extract induces cell injury via intracellular Ca2+-dependent subtype-specific protein kinase C activation2012
- Author(s)
  Mai Y, Higashi T, Terada K, Hatate C, Nepal P, Horiguchi M, Harada T, Miwa S, Horinouchi T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 120 Pages: 310-314
- NAID
  10031147580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659129
[Journal Article] The ECS(SPSB) E3 ubiquitin ligase is the master regulator of the lifetime of inducible nitric-oxide synthase2011
- Author(s)
  Matsumoto K., Nishiya T., Maekawa S., Horinouchi T., Ogasawara K., Uehara T and Miwa S.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 409 Pages: 46-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Juvenile stress attenuates the dorsal hippocampal postsynaptic 5-HT1A receptor function in adult rats2011
- Author(s)
  Matsuzaki H., Izumi T., Horinouchi T., Boku S., Inoue T., Yamaguchi T., Yoshida T., Matsumoto M., Togashi H., Miwa S., Koyama T. and Yoshioka M.
- Journal Title
  
  Psychopharmacology (Berl)
  
  Volume: 214 Pages: 329-337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Effect of cigarette smoke components on vascular smooth muscle cell migration toward platelet-derived growth factor BB.2011
- Author(s)
  Yoshiyama S., Horinouchi T., Miwa S., Wang H. H., Kohama K. and Nakamura A.
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 115 Pages: 532-535
- NAID
  10029893589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Regulation of inducible nitric-oxide synthase by the SPRY domain-and SOCS box-containing proteins2011
- Author(s)
  Nishiya T., Matsumoto K., Maekawa S., Kajita E., Horinouchi T., Fujimuro M., Ogasawara K., Uehara T. and Miwa S.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 9009-9019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Jab1 regulates levels of endothelin type A and B receptors by promoting ubiquitination and degradation.2010
- Author(s)
  Nishimoto A., Lu L., Hayashi M., Nishiya T., Horinouchi T. and Miwa S.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 391 Pages: 1616-1622
- NAID
  120001909636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Endothelin type Breceptor-induced sustained Ca2+ influx involves G(q/11)/phospholipase C-independent, p38 mitogen-activated protein kinase-dependent activation of Na+/H+ exchanger.2010
- Author(s)
  Higa T., Horinouchi T., Aoyagi H., Asano H., Nishiya T., Nishimoto A., Muramatsu I. and Miwa S.
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 113 Pages: 276-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Pharmacological evaluation of ocular beta-adrenoceptors in rabbit by tissue segment binding method.2009
- Author(s)
  Hrinouchi T., Morishima S., Tanaka Y., Koike K., Miwa S. and Muramatsu I.
- Journal Title
  
  Life Sci.
  
  Volume: 84 Pages: 181-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Molecular mechanisms of sustained Ca2+ influx triggerd by G protein-coupled receptors2009
- Author(s)
  Horinouchi T, Miwa S
- Journal Title
  
  Nippon Yakurigaku Zasshi. 134(1)
  
  Pages: 8-12
- NAID
  10025741036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Differential coupling of human endothelin type A receptor to G(q/11) and G(12) proteins : the functional significance of receptor expression level in generating multiple receptor signaling.2009
- Author(s)
  Horinouchi T., Asano H., Higa T., Nishimoto A., Nishiya T., Muramatsu I. and Miwa S.
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 111 Pages: 338-351
- NAID
  130000132483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390068
[Journal Article] Pharmacological evaluation of ocular beta-adrenoceptors in rabbit by tissue segment binding method2009
- Author(s)
  Horinouchi T, Morishima S, Tanaka Y, Koike K, Miwa S, Muramatsu I
- Journal Title
  
  Life Sciences 84(5-6)
  
  Pages: 181-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] ホルモンの病態異常と検査 9.血管制御因子 2)エンドセリン2008
- Author(s)
  三輪聡一
- Journal Title
  
  臨床検査第52巻
  
  Pages: 1287-1294
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] ホルモンの病態異常と臨床検査各論Iホルモンの病態異常と検査9. 血管制御因子2)エンドセリン2008
- Author(s)
  三輪聡一
- Journal Title
  
  臨床検査第52巻
  
  Pages: 1287-1294
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] Characterization of noradrenaline-induced increases in intracellular Ca^<2+> levels in Chinese hamster ovary cells stablyexpressing human α1A-adrenoceptor2007
- Author(s)
  Horinouchi T, Miyake Y, Nishiya T, Nishimoto A, Yorozu S, Jinno A, Kajita E, Miwa S
- Journal Title
  
  J Pharmacol Sci 105(1)
  
  Pages: 103-111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] Improvement of postischemic dopaminergic dysfunction by edaravone, a free radical scavenger2007
- Author(s)
  Akiyama Y, Miwa S
- Journal Title
  
  J Pharmacol Sci 104(1)
  
  Pages: 99-102
- NAID
  10024314147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] Endothelin-1 decreases [Ca^<2+>]i via Na^+/Ca^<2+> exchanger in CHO cells stably expressing endothelin ETA receptor2007
- Author(s)
  Horinouchi T, Nishimoto A, Nishiya T, Lu L, Kajita E, Miwa S
- Journal Title
  
  Eur J Pharmacol 566(1-3)
  
  Pages: 28-33
- NAID
  120000965254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] 循環系調節因子としてのエンドセリンにより活性化される細胞内カルシウムシグナルとその調節系2007
- Author(s)
  三輪聡一、堀之内孝広、西本新、西屋禎
- Journal Title
  
  適応医学 11(2)
  
  Pages: 34-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] Different changes of plasma membrane β-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol2007
- Author(s)
  Horinouchi T, Morishima S, Tanaka T, Suzuki F, Tanaka Y, Koike K, Miwa S, Muramatsu I
- Journal Title
  
  Life Sci 81(5)
  
  Pages: 399-404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] OCTN2VT, a splice variant of OCTN2, does not transport carnitine because of the retention in the endoplasmic reticulum caused by insertion of 24 amino acids in the first extracellular loop of OCTN22007
- Author(s)
  Maekawa S, Mori D, Nishiya T, Takikawa O, Horinouchi T, Nishimoto A, Kajita E, Miwa S
- Journal Title
  
  Biochim Biophys Acta (Mol Cell Res) 1773(6)
  
  Pages: 1000-1006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD882007
- Author(s)
  Nishiya T, Kajita E, Horinouchi T, Nishimoto A, Miwa S
- Journal Title
  
  FEBS Lett 581(17)
  
  Pages: 3223-3229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] Ligand-independent oligomerization of TLR4 regulated by a short hydrophobic region adjacent to the transmembrane domain2006
- Author(s)
  Nishiya T, Kajita E, Miwa S
- Journal Title
  
  Biochem Biophys Res Commun 341(4)
  
  Pages: 128-1134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] The transmembrane domain directs TLR9 to intracellular compartments that contain TLR32006
- Author(s)
  Kajita E, Nishiya T, Miwa S
- Journal Title
  
  Biochem Biophys Res Commun 343(2)
  
  Pages: 578-584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN22006
- Author(s)
  Nagai K, Takikawa O, Kawakami N, Fukao M, Soma T, Oda A, Nishiya T, Hayashi M, Lu L, Nakano M, Kajita E, Fujita H, Miwa S
- Journal Title
  
  Arch Biochem Biophys 452(1)
  
  Pages: 29-37
- NAID
  120000960814
- Data Source
  KAKENHI-PROJECT-18390072
[Journal Article] Ca^<2+> entry channels involved in endothelin-induced contractions of vascular smooth muscle cells.2005
- Author(s)
  Miwa S, et al.
- Journal Title
  
  J Smooth Muscle Res 41・2
  
  Pages: 61-76
- Data Source
  KAKENHI-PROJECT-15390075
[Journal Article] Ca^<2+> entry channels involved in endothelin-1-induced contractions of vascular smooth muscle cells.2005
- Author(s)
  Miwa, S., et al.
- Journal Title
  
  Journal of Smooth Muscle Research (in press)
- NAID
  110002950119
- Data Source
  KAKENHI-PROJECT-15390075
[Journal Article] Ca^<2+> entry channels involved in endothelin-induced contractions of vascular smooth muscle cells.2005
- Author(s)
  Miwa S.
- Journal Title
  
  J Smooth Muscle Res 41(2)
  
  Pages: 61-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390075
[Journal Article] Ca^2+ entry channels involved in endothelin-induced contractions of vascular smooth muscle cells.2005
- Author(s)
  Miwa S.
- Journal Title
  
  J Smooth Muscle Res 41(2)
  
  Pages: 61-76
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390075
[Journal Article] Vascular action of endothelin.2004
- Author(s)
  Miwa S.
- Journal Title
  
  Nippon Rinsho 62(Suppl 9)
  
  Pages: 608-611
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390075
[Journal Article] Macrophage stimulating action of endothelin.2004
- Author(s)
  Miwa S.
- Journal Title
  
  Nippon Rinsho 62(Suppl 9)
  
  Pages: 632-635
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390075
[Journal Article] エンドセリンのマクロファージ活性化作用2004
- Author(s)
  三輪聡一
- Journal Title
  
  日本臨牀増刊「臨床分子内分泌学(1)」 62・増刊9
  
  Pages: 632-635
- Data Source
  KAKENHI-PROJECT-15390075
[Journal Article] エンドセリンの血管作用2004
- Author(s)
  三輪聡一
- Journal Title
  
  日本臨牀増刊「臨床分子内分泌学(1)」 62・増刊9
  
  Pages: 608-611
- Data Source
  KAKENHI-PROJECT-15390075
[Presentation] タバコ煙ガス相中の細胞傷害成分の同定と細胞傷害メカニズムの解析2014
- Author(s)
  東恒仁，眞井洋輔，堀之内孝広，寺田晃士，星暁壮，堀口美香，Nepal Prabha，原田拓弥，旗手千鶴，三輪聡一
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター，仙台
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] エンドセリンB型受容体のトラフィッキングにおける受容体ユビキチン化の役割2014
- Author(s)
  寺田晃士、堀之内孝広、東恒仁、Nepal Prabha、堀口美香、旗手千鶴、星暁壮、眞井洋輔、原田拓弥、三輪聡一
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台（仙台国際センター）
- Data Source
  KAKENHI-PROJECT-25460326
[Presentation] ユビキチン化によるエンドセリン受容体の細胞内トラフィキング制御2014
- Author(s)
  三輪聡一、寺田晃士、東恒仁、Nepal Prabha、堀之内孝広
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-25670123
[Presentation] ラット骨格筋細胞においてエンドセリン-1により活性化されるシグナル伝達機構の解明2014
- Author(s)
  星暁壮、堀之内孝広、原田拓弥、比嘉綱己、東恒仁、寺田晃士、眞井洋輔、ネパールプラハ、堀口美香、旗手千鶴、三輪聡一
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（仙台市）
- Data Source
  KAKENHI-PROJECT-25670123
[Presentation] エンドセリン受容体シグナルソーム形成からみた治療戦略2014
- Author(s)
  堀之内孝広、寺田晃士、東恒仁、星暁壮、三輪聡一
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  東北大学（仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-25670123
[Presentation] ユビキチン化によるエンドセリン受容体の細胞内トラフィッキング制御2014
- Author(s)
  三輪聡一，寺田晃士，東恒仁，Nepal Prabha，堀之内孝広
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター，仙台
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] タバコ煙ガス相中の細胞傷害成分の同定と細胞傷害メカニズムの解析2014
- Author(s)
  東恒仁、眞井洋輔、堀之内孝広、寺田晃士、星暁壮、堀口美香、Prabha Nepal、原田拓弥、旗手千鶴、三輪聡一
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（仙台市）
- Data Source
  KAKENHI-PROJECT-25670123
[Presentation] ラット骨格筋細胞においてエンドセリン-1により活性化されるシグナル伝達機構の解明2014
- Author(s)
  星暁壮，堀之内孝広，原田拓弥，比嘉綱己，東恒仁，寺田晃士，眞井洋輔，ネパル・プラハ，堀口美香，旗手千鶴，三輪聡一
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター，仙台
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] エンドセリンB型受容体のトラフィッキングにおける受容体ユビキチン化の役割2014
- Author(s)
  寺田晃士、堀之内孝広、東恒仁、Nepal Prabha、堀口美香、旗手千鶴、星暁壮、眞井洋輔、原田拓弥、三輪聡一
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（仙台市）
- Data Source
  KAKENHI-PROJECT-25670123
[Presentation] エンドセリン受容体シグナルソーム形成からみた治療戦略2014
- Author(s)
  堀之内孝広，寺田晃士，東恒仁，星暁壮，三輪聡一
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター，仙台
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] エンドセリンB型受容体のトラフィッキングにおける受容体ユビキチン化の役割2014
- Author(s)
  寺田晃士，堀之内孝広，東恒仁，Nepal Prabha，堀口美香，旗手千鶴，星暁壮，眞井洋輔，原田拓弥，三輪聡一
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター，仙台
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] ニコチン及びタール除去タバコ煙抽出物中に含まれる細胞傷害因子の性状解析2013
- Author(s)
  東恒仁，眞井洋輔，堀之内孝広，寺田晃士，旗手千鶴，星暁壮，Prabha Nepal，堀口美香，三輪聡一
- Organizer
  第64回日本薬理学会北部会
- Place of Presentation
  大雪クリスタルホール，北海道
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] エンドセリン-1による骨格筋インスリン・シグナルの抑制性制御機構の解明2013
- Author(s)
  原田拓弥，堀之内孝広，東恒仁，寺田晃士，比嘉綱己，眞井洋輔，星暁壮，Nepal Prabha，堀口美香，旗手千鶴，三輪聡一
- Organizer
  第27回北海道薬物作用談話会
- Place of Presentation
  酪農学園大学，北海道
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] アデニル酸シクラーゼ-cAMP-プロテインキナーゼA系によるエンドセリン受容体活性化型TRPC6チャネルを介した受容体作動性Ca2+流入の抑制性制御2013
- Author(s)
  堀之内孝広, 寺田晃士, 東恒仁, 比嘉綱己, 原田拓弥, 三輪聡一
- Organizer
  第42回日本心脈管作動物質学会
- Place of Presentation
  奈良県新公会堂,奈良
- Year and Date
  2013-02-08
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] ニコチン及びタール除去タバコ煙抽出物に含まれる細胞傷害因子の性状解析2013
- Author(s)
  東恒仁、眞井洋輔、堀之内孝広、寺田晃士、旗手千鶴、星暁壮、Prabha Nepal、堀口美香、三輪聡一
- Organizer
  第64回日本薬理学会北部会
- Place of Presentation
  大雪クリスタルホール（旭川市）
- Data Source
  KAKENHI-PROJECT-25670123
[Presentation] エンドセリンB型受容体のET-1刺激誘発的な細胞内移行とシグナルの制御におけるユビキチン修飾の役割2013
- Author(s)
  寺田晃士、堀之内孝広、東恒仁、Nepal Prabha、堀口美香、旗手千鶴、星暁壮、三輪聡一
- Organizer
  第64回日本薬理学会北部会
- Place of Presentation
  大雪クリスタルホール（旭川市）
- Data Source
  KAKENHI-PROJECT-25670123
[Presentation] 骨格筋細胞におけるエンドセリン受容体を介したインスリン・シグナリングの抑制性制御機構の解明2013
- Author(s)
  堀之内孝広、原田拓弥、東恒仁、寺田晃士、比嘉綱己、眞井洋輔、星暁壮、Nepal Prabha、堀口美香、旗手千鶴、三輪聡一
- Organizer
  第64回日本薬理学会北部会
- Place of Presentation
  大雪クリスタルホール（旭川市）
- Data Source
  KAKENHI-PROJECT-25670123
[Presentation] ニコチン及びタール除去タバコ煙水抽出物はCa2+依存的にPKCを活性化することで細胞傷害を引き起こす2013
- Author(s)
  東恒仁, 眞井洋輔, 堀之内孝広, 寺田晃士, 旗手千鶴, 三輪聡一
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場,福岡
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] エンドセリンB型受容体の動態制御におけるユビキチン化修飾の役割2013
- Author(s)
  寺田晃士, 堀之内孝広, 東恒仁, 旗手千鶴,三輪聡一
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場,福岡
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] エンドセリン-1によるインスリン-Aktシグナル伝達の抑制性制御におけるGタンパク質共役型受容体キナーゼ2の関与2013
- Author(s)
  堀之内孝広，原田拓弥，星暁壮，東恒仁，寺田晃士，比嘉綱己，眞井洋輔，Nepal Prabha，堀口美香，旗手千鶴，三輪聡一
- Organizer
  第23回日本循環薬理学会
- Place of Presentation
  福岡大学メディカルホール，福岡
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] エンドセリンB型受容体のET-1刺激誘発的な細胞内移行とシグナルの制御におけるユビキチン修飾の役割2013
- Author(s)
  寺田晃士，堀之内孝広，東恒仁，Nepal Prabha，堀口美香，旗手千鶴，星暁壮，三輪聡一
- Organizer
  第64回日本薬理学会北部会
- Place of Presentation
  大雪クリスタルホール，北海道
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] エンドセリン-1による骨格筋インスリン・シグナルの抑制性制御機構の解明2013
- Author(s)
  原田拓弥、堀之内孝広、東恒仁、寺田晃士、比嘉綱己、眞井洋輔、星暁壮、Nepal Prabha、堀口美香、旗手千鶴、三輪聡一
- Organizer
  第27回北海道薬物作用談話会
- Place of Presentation
  酪農学園大学（江別市）
- Data Source
  KAKENHI-PROJECT-25670123
[Presentation] エンドセリン-1によるインスリン-Aktシグナル伝達の抑制性制御におけるGタンパク質共役型受容体キナーゼ2の関与2013
- Author(s)
  堀之内孝広、原田拓弥、星暁壮、東恒仁、寺田晃士、比嘉綱己、眞井洋輔、Nepal Prabha、堀口美香、旗手千鶴、三輪聡一
- Organizer
  第23回日本循環薬理学会
- Place of Presentation
  福岡大学（福岡市）
- Data Source
  KAKENHI-PROJECT-25670123
[Presentation] 骨格筋細胞におけるエンドセリン受容体を介したインスリン・シグナルの抑制性制御機構の解明2013
- Author(s)
  堀之内孝広，原田拓弥，東恒仁，寺田晃士，比嘉綱己，眞井洋輔，星暁壮，Nepal Prabha，堀口美香，旗手千鶴，三輪聡一
- Organizer
  第64回日本薬理学会北部会
- Place of Presentation
  大雪クリスタルホール，北海道
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] エンドセリンB型受容体の動態制御におけるユビキチン化の役割の解析2012
- Author(s)
  寺田晃士, 堀之内孝広, 東恒仁, 旗手千鶴, 三輪聡一
- Organizer
  第63回日本薬理学会北部会
- Place of Presentation
  朱鷺メッセ,新潟
- Year and Date
  2012-09-14
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] ユビキチン化によるエンドセリン受容体の動態制御機構の解析2012
- Author(s)
  寺田晃士, 堀之内孝広, 東恒仁, 旗手千鶴, 三輪聡一
- Organizer
  第22回日本循環薬理学会
- Place of Presentation
  富山国際会議場,富山
- Year and Date
  2012-11-30
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] 肺高血圧症の発症・進展に寄与するTRPC6チャネルの抑制性機能制御機構2012
- Author(s)
  堀之内孝広, 比嘉綱己, 東恒仁, 寺田晃士, 旗手千鶴, 三輪聡一
- Organizer
  第1回日本肺循環学会学術集会
- Place of Presentation
  東京ステーションコンファレンス,東京
- Year and Date
  2012-09-22
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] ニコチン及びタール除去タバコ煙抽出液の細胞傷害作用に関与するPKCアイソザイムの同定とその活性化機構の解明2012
- Author(s)
  眞井洋輔, 東恒仁, 寺田晃士, 旗手千鶴, 堀之内孝広, 三輪聡一
- Organizer
  第26回北海道薬物作用談話会
- Place of Presentation
  北海道大学,北海道
- Year and Date
  2012-07-28
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] ニコチン及びタール除去タバコ煙抽出物の細胞傷害作用に関与するPKCアイソザイムの同定と活性化機構の解明2012
- Author(s)
  東恒仁, 眞井洋輔,寺田晃士, 旗手千鶴,堀之内孝広,三輪聡一
- Organizer
  第63回日本薬理学会北部会
- Place of Presentation
  朱鷺メッセ,新潟
- Year and Date
  2012-09-14
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] 小胞体Ca2+センサーSTIM1の新規バリアントの同定とその分子薬理学的特性の解析2012
- Author(s)
  堀之内孝広, 比嘉綱己, 東恒仁, 寺田晃士, 旗手千鶴, 三輪聡一
- Organizer
  第63回日本薬理学会北部会
- Place of Presentation
  朱鷺メッセ,新潟
- Year and Date
  2012-09-14
- Data Source
  KAKENHI-PROJECT-24390059
[Presentation] 受容体結合蛋白質Jab1によるエンドセリンA型受容体の発現レベル調節機構とその病態的意義2009
- Author(s)
  三輪聡一
- Organizer
  第37回薬物活性シンポジウム
- Place of Presentation
  東北薬科大学(宮城県)
- Data Source
  KAKENHI-PROJECT-21390068
[Presentation] 循環器系調節因子としてのエンドセリンにより活性化される細胞内カルシウムシグナルとその調節系2007
- Author(s)
  三輪聡一
- Organizer
  第11回日本適応医学会学術集会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2007-06-09
- Data Source
  KAKENHI-PROJECT-18390072
[Presentation] MOLECULAR MECHANISMS FOR Ca^<2+>SIGNALING ACTIVATED BY ENDOTHELIN-12007
- Author(s)
  Soichi Miwa
- Organizer
  The 5th US/Japan Workshop on Molecular and Cellular Aspects of Vascular Smooth Muscle Function
- Place of Presentation
  Hawaii
- Data Source
  KAKENHI-PROJECT-18390072
[Presentation] 循環器系調節因子としてのエンドセリンにより活性化される佐井細胞内カルシウムシグナルとその調節系2007
- Author(s)
  三輪聡一
- Organizer
  第11回日本適応医学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-18390072
[Presentation] 新規エンドセリン受容体結合蛋白質Jab1によるエンドセリン誘導性ERKリン酸化の調節2006
- Author(s)
  三輪聡一
- Organizer
  第16回日本循環薬理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390072
[Presentation] エンドセリンB型受容体の細胞内動態におけるユビキチン化の役割
- Author(s)
  寺田晃士、堀之内孝広、東恒仁、堀口美香、Prabha Nepal、Sarita Karki、旗手千鶴、原田拓弥、眞井洋輔、星暁壮、三輪聡一
- Organizer
  第65回日本薬理学会北部会
- Place of Presentation
  コラッセふくしま（福島県）
- Year and Date
  2014-09-26 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460326
[Presentation] エンドセリンB型受容体のET-1刺激誘発的な細胞内移行とシグナルの制御におけるユビキチン修飾の役割
- Author(s)
  寺田晃士、堀之内孝広、東恒仁、Nepal Prabha、堀口美香、旗手千鶴、星暁壮、三輪聡一
- Organizer
  第64回日本薬理学会北部会
- Place of Presentation
  旭川（大雪クリスタルホール）
- Data Source
  KAKENHI-PROJECT-25460326

1. MISAKI Tomoh (60009991)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. NINOMIYA Haruaki (80212124)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. SAWAMURA Tatsuya (30243033)

# of Collaborated Projects: 8 results

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4. 越村邦夫 (90192575)

# of Collaborated Projects: 5 results

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5. FUKAO Mitsuhiro (10250432)

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6. FUJIWARA Motohatsu (90025536)

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7. NARUMIYA Shu (70144350)

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8. HATTORI Yuichi (50156361)

# of Collaborated Projects: 3 results

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9. HORINOUCHI Takahiro (20307771)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
10. TANIGUCHI Takashi (10111957)

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11. KURAHASHI Kazuyoshi (10025653)

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12. VANHOUTTE P.

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13. VANE J.

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14. 真崎知生

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15. NISHIYA Tadashi (80399831)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
16. NISHIMOTO Arata (90396325)

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# of Collaborated Products: 8 results
17. TERADA Koji (70342722)

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# of Collaborated Products: 9 results
18. OKAMOTO Shinichiro (40160717)

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19. TAKIKAWA Osamu (70163342)

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20. 岡本安雄 (80293877)

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21. ICHISE Mitsunojo (00025917)

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22. MORISHITA Fujio (30026281)

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23. WATANABE Yasuyoshi (40144399)

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24. ONOE Hirotaka (80214196)

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25. INOUE Osamu (50159969)

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26. TONE Shigenobu (70211399)

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27. TSUTSUI Hiroyuki (70264017)

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28. CHIBA Hitoshi (70197622)

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29. KANG Dongchon (80214716)

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30. ICHIKAWA Kazuhiro (10271115)

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31. ISHIMORI Naoki (70399848)

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32. 福本学 (60156809)

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33. 比企一晃 (30263099)

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34. 藤井聡 (90291228)

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35. LANGSTROM Bengt

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36. 渡邊恭良

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37. BENGT Langst

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38. VANE John

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39. HIGASHI Tsunehito

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40. MAI Yosuke

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MIWA Soichi 三輪 聡一

MIWA Souiti 三輪 聡一

三輪 聡 ミワ ソウイチ

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タバコ煙中低分子化合物による細胞傷害メカニズムの解明と無毒化タバコ作製の試みPrincipal Investigator

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エンドセリン受容体結合蛋白質によるシグナルソーム形成を介した２型糖尿病発症機序Principal Investigator

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Elucidation of molecular mechanism of cell damage by cigarette smoke extract and development of cigarette smoke detoxification methodsPrincipal Investigator

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Study of the regulatory mechanism of ETAR and ETBR level by receptor binding protein and the relevance between clinical significance and endothelin receptor level.Principal Investigator

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Search for novel signal molecules which are directly activated by endothelin receptorPrincipal Investigator

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Structure and function of receptor-operated Ca^<2+> channels and development of specific blockers of the channelsPrincipal Investigator

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内皮由来過分極因子の分離・同定・機能解析Principal Investigator

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The structure and function of voltage-independent Ca^<2+> channels involved in vascular contractionsPrincipal Investigator

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The structure and function of Ca^<2+>-permeable nonselective cation channelsPrincipal Investigator

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MIWA Soichi 三輪聡一

MIWA Souiti 三輪聡一

三輪聡ミワソウイチ