• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Suemizu Hiroshi  末水 洋志

… Alternative Names

SUEMIZU HIROSHI  末水 洋志

SUEMIZU Hiroshi  末水 洋志

SUEMIZU Youji  末水 洋司

Less
Researcher Number 40332209
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-3706-2454
Affiliation (Current) 2025: 公益財団法人実中研, バイオメディカル研究部門, 部門長
2025: 公益財団法人実中研, ヒト化モデル研究部, 部長
Affiliation (based on the past Project Information) *help 2020 – 2022: 公益財団法人実験動物中央研究所, 研究部門, 部門長
2016 – 2019: 公益財団法人実験動物中央研究所, 実験動物研究部, 部長
2014: 公益財団法人実験動物中央研究所, 主任研究員
2014: 公益財団法人実験動物中央研究所, 実験動物研究部, 部長
2013 – 2014: 公益財団法人実験動物中央研究所, その他部局等, 研究員 … More
2013 – 2014: 公益財団法人実験動物中央研究所, バイオメディカル研究部, 部長
2011: 公益財団法人実験動物中央研究所, バイオメディカル研究部, 部長
2011: 実験動物中央研究所, バイオメディカル研究部, 部長
2010: (財)実験動物中央研究所, 分子解析研究室, 室長
2010: 財団法人実験動物中央研究所, バイオメディカル研究部, 部長
2009: Central Institute for Experimental Animals, バイオメディカル研究部, 部長
2007: Central Institute for Experimental Animals, Department of Biomedical Research, Researcher
2007: 財団法人実験動物中央研究所, 分子解析研究室, 室長
2005 – 2007: 財団法人実験動物中央研究所, 研究員
2006: (財)実験動物中央研究所, 分子解析研究室, 室長
2005 – 2006: (財)実験動物中央研究所, バイオメディカル研究部, 室長
2005: 東海大学, 実験動物中央研究所, 研究員
2004 – 2005: Central Institute of Laboratory Animals, Researcher, 研究員
2004: (財)実験動物中央研究所, 研究員
2003: 東京大学, 実験動物中央研究所, 研究員
2001 – 2003: 財団法人実験動物中央研究所, 研究プロジェクトセンター, 研究員
2002: 実験動物中央研究所, 研究員 Less
Review Section/Research Field
Principal Investigator
Laboratory animal science / Laboratory animal science / Basic Section 42040:Laboratory animal science-related
Except Principal Investigator
Laboratory animal science / Laboratory animal science / Experimental pathology / Cerebral neurosurgery / Gastroenterology
Keywords
Principal Investigator
ヒト肝キメラマウス / ヒト化マウス / 肝再生 / ヒト化肝臓 / タンパク結合 / 薬物体内分布 / ヒト肝細胞 / 薬物動態 / 肝逸脱酵素 / Plasma circulating RNA … More / バイオマーカー / 薬剤性肝障害 / 肝毒性 / hepatocytes transplantation / liver regeneration / immunodeficient NOG mice / 肝細胞移植 / 高度免疫不全NOGマウス / Tg-Fucci-S/G2/M-Greenマウス / FucciTgマウス / 肝幹細胞 / ガン転移 / ヒト化肝臓モデル / ヒューマナィズドマウス / ヒューマナイズド / 転移モデル / 細胞・組織 / がん / 大腸がん / 膵臓がん / がん転移 / TK-NOGマウス / uPA-NOGマウス / ヒューマナイズドマウス / 免疫不全マウス … More
Except Principal Investigator
実験動物 / Microsatellite DNA marker / Callithrix jacchus / in vivo / S100A4 / Lactobacillus / 16S rDNA / Clostridium / Bacteroidaseae / Fusiform shaped bacteria / ヒト化モデル / 発生・分化 / NOGマウス / 免疫不全マウス / 病態モデル / Chromosomemap / Karvotvpe / Chromosome / SNP (single nucleotide polvmorphism) / MHC class II gene / Common marmoset / Simple sequence repeat / ドラフトシークエンス / Glucose phosphate isomerase / Transferrin / PCR-RFLP / ミトコンドリアDNA多型 / 高等霊長類 / Microsatellite marker / DQA1遣伝子 / 染色体地図 / 核型 / 染色体 / SNP / MHC class II遺伝子 / コモンマーモセット / Distant metastasis / NOG mouse / DNA chip analysis / Malignant melanoma / Large intestinal cancer / Pancreatic cancer / 転移 / 遠隔転移 / DNAチップ解析 / 悪性黒色腫 / 大腸癌 / 膵癌 / FISH method / Intestinal flora / Fushiform shaped bacteria / 16sDNA / Bacteroides / Fushiform shaped bactria / FISF法 / Lactobachillus / FISH法 / 腸内フローラ / personalized chemotherapy / htranslational research / eresistance / ant-cancer drug / microarray / nude mouse / human tumor / xenograft / オーダーメード医療 / トランスレーショナル研究 / 耐性 / 抗がん剤 / マイクロアレイ / ヌードマウス / ゼノグラフト / ヒト腫瘍 / 薬剤反応性 / 脳神経疾患 / 細胞・組織 / 癌 / niche / undifferentiated state / proliferation / survival / glioma stem cell / Kupffer細胞 / 肝発癌 / Th2サイトカイン / 非アルコール性脂肪肝炎 / 非アルコール性脂肪性肝疾患 / グリシン / アミノ酸 / 免疫栄養 / 制御性T細胞 / NKT細胞 / 自然免疫 / メタボリックシンドローム / 非アルコール性脂肪肝炎(NASH) / 肝細胞移植 / 幹細胞移植 / 肝胆道疾患 / 疾患肝細胞 / 免疫不全肝障害マウス / ヒト肝型マウス / 手術摘出検体 / 疾患モデル / 個別衣料 / 免疫不全動物 / 個別化医療 / 個別医療 / 実験動物学 / ヒト化マウス / ヒト疾患モデル / ヒト化動物モデル Less
  • Research Projects

    (14 results)
  • Research Products

    (60 results)
  • Co-Researchers

    (34 People)
  •  Development of a composite humanized liver chimeric mouse that contributes to pharmacokinetic studies and its application to drug discovery researchPrincipal Investigator

    • Principal Investigator
      Suemizu Hiroshi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42040:Laboratory animal science-related
    • Research Institution
      Central Institute for Experimental Animals
  •  Development of human specific hepatotoxicity evaluation method using humanized liver mouse and elucidation of species differences in the pathogenesis of toxicityPrincipal Investigator

    • Principal Investigator
      SUEMIZU HIROSHI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Basic research for development of artificial liver stem cellPrincipal Investigator

    • Principal Investigator
      SUEMIZU Hiroshi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Innate immune regulation of hepatic metabolism and immuno-nutritional approach for nonalcoholic fatty liver disease

    • Principal Investigator
      IKEJIMA Kenichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Analysis of niche involved with survival, proliferation, and maintenance of undifferentiated state of glioma stem cell

    • Principal Investigator
      KANEMURA Yonehiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      National Hospital Organization Osaka National Hospital Institute for Clinical Reserch
  •  Development of humanized-liver mice using hepatocyte derived from isolated liver tissue from recipient or donor of living donor liver transplantation

    • Principal Investigator
      TANOUE Akito
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      National Research Institute for Child Health and Development
  •  Development of experimentation systems related to personalized medicine using humanized NOG mice

    • Principal Investigator
      ITO Mamoru
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Elucidating the mechanism of human cancer metastasis using a humanized cancer metastasis model.Principal Investigator

    • Principal Investigator
      SUEMIZU Hiroshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Laboratory animal science
    • Research Institution
      実験動物中央研究所
      Central Institute for Experimental Animals
  •  Basic study to establish "humanized animal model" by improvement and modification of severely immunodeficient NOG mouse

    • Principal Investigator
      ITO Mamoru
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Studies on development of genome markers and application to colonies in the common marmoset

    • Principal Investigator
      KATOH Hideki
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Hamamatsu University School of Medicine
  •  Development of humanized NOG mice reconstituted with human hepatocytes and their applications in drug discovery and infectious disease research.Principal Investigator

    • Principal Investigator
      SUEMIZU Hiroshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in NOD/SCID/_<γ_c>^<null> (NOG) mice.

    • Principal Investigator
      NAKAMURA Masato
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokai University
  •  Development of monitaruin system for intestinal flora of experimental animals using FISH method

    • Principal Investigator
      ITOH Kikuji
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      The University of Tokyo
  •  Establishment of human tumor xenotransplantation models as a pre-clinical assisting tool for translational research

    • Principal Investigator
      OHNISHI Yasuyuki
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals

All 2022 2019 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 Other

All Journal Article Presentation Patent

  • [Journal Article] An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals2022

    • Author(s)
      Uehara Shotaro、Higuchi Yuichiro、Yoneda Nao、Kawai Kenji、Yamamoto Masafumi、Kamimura Hidetaka、Iida Yuichi、Oshimura Mitsuo、Kazuki Yasuhiro、Yamazaki Hiroshi、Hikita Hayato、Takehara Tetsuo、Suemizu Hiroshi
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 42 Pages: 100410-100410

    • DOI

      10.1016/j.dmpk.2021.100410

    • NAID

      210000173085

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03150, KAKENHI-PROJECT-20K06463
  • [Journal Article] Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2-Producing Transgenic NOG Mouse2015

    • Author(s)
      Katano, I. Takahashi, T. Ito, R. Kamisako, T. Mizusawa, T. Ka, Y. Ogura, T. Suemizu, H. Kawakami, Y. Ito, M.
    • Journal Title

      J Immunol

      Volume: 194 Issue: 7 Pages: 3513-3525

    • DOI

      10.4049/jimmunol.1401323

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-25871075, KAKENHI-PROJECT-26221005, KAKENHI-PROJECT-26290034, KAKENHI-PROJECT-25430099
  • [Journal Article] contributed equally to this work. Hepatocytes buried in the cirrhotic livers of biliary atresia patients proliferate and function in the liver of uPA-NOG mice2014

    • Author(s)
      Suemizu H, Nakamura K, Kawai K, Higuchi Y, Kasahara M, Fujimoto J, Tanoue A, Nakamura M
    • Journal Title

      Liver Transplantation

      Volume: (In press) Issue: 9 Pages: 1127-1137

    • DOI

      10.1002/lt.23916

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300162, KAKENHI-PROJECT-24650244, KAKENHI-PROJECT-25460088, KAKENHI-PROJECT-25640055
  • [Journal Article] NOD-Rag2(null) IL-2Rgamma(null) Mice: An Alternative to NOG Mice for Generation of Humanized Mice2014

    • Author(s)
      Katano, I. Ito, R. Kamisako, T. Eto, T. Ogura, T. Kawai, K. Suemizu, H. Takahashi, T. Kawakami, Y. Ito, M.
    • Journal Title

      Exp Anim

      Volume: 63 Pages: 321-30

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-22220007
  • [Journal Article] The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice2014

    • Author(s)
      Higuchi Y, Kawai K, Yamazaki H, Nakamura M, Bree F, Guguen-Guillouzo C, Suemizu H
    • Journal Title

      Xenobiotica

      Volume: 44 Pages: 146-153

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25640055
  • [Journal Article] A Novel Enhanced Green FluorescentProtein-Expressing NOG Mouse for Analyzingthe Microenvironment of Xenograft Tissues2014

    • Author(s)
      Yuichiro Higuchi, Kenji Kawai, Masafumi Yamamoto, Miyuki Kuronuma, Yasuhiko Ando, Ikumi Katano, Masato Nakamura, Hiroshi Suemizu
    • Journal Title

      Exp. Anim.

      Volume: 63 Issue: 1 Pages: 55-62

    • DOI

      10.1538/expanim.63.55

    • NAID

      130003391611

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24700439, KAKENHI-PROJECT-25640055
  • [Journal Article] Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice.2013

    • Author(s)
      Ito, R., T. Takahashi, I. Katano, K. Kawai, T. Kamisako, T. Ogura, M. Ida-Tanaka, H. Suemizu, S. Nunomura, C. Ra, A. Mori, S. Aiso, and M. Ito.
    • Journal Title

      J Immunol

      Volume: 191 Issue: 6 Pages: 2890-2899

    • DOI

      10.4049/jimmunol.1203543

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-23590561, KAKENHI-PROJECT-25430099, KAKENHI-PROJECT-25871075
  • [Journal Article] Aldehyde dehydrogenase activity in cancer stem cells from canine mammary carcinoma cell lines2012

    • Author(s)
      Michishita, M., Suemizu, H.(8名・3番目)
    • Journal Title

      Vet

      Volume: (in press) Issue: 2 Pages: 508-513

    • DOI

      10.1016/j.tvjl.2012.01.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042, KAKENHI-PROJECT-24780314
  • [Journal Article] In vive Formation of Dihydroxylated and Glutathione Conjugate Metabolites Derived from Thalidomide and 5-Hydroxythalidomide in Humanized2012

    • Author(s)
      Yamazaki, H., Suemizu, H.(8名・2番目)
    • Journal Title

      TK-NOG Mice Chem Res Toxicol

      Volume: 25 Pages: 274-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG2011

    • Author(s)
      Yamazaki, H., Suemizu, H.(8名・2番目)
    • Journal Title

      Mice Chem Res Toxicol

      Volume: 24 Issue: 3 Pages: 287-289

    • DOI

      10.1021/tx200005g

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042, KAKENHI-PROJECT-21390030, KAKENHI-PROJECT-21590177, KAKENHI-PUBLICLY-22106515, KAKENHI-PROJECT-23590200
  • [Journal Article] Semi-quantitative analyses of metabolic systems of human colon cancer metastatic xenografts in livers of superimmunodeficient NOG mice2011

    • Author(s)
      Kubo, A., Suemizu, H.(10名・7番目)
    • Journal Title

      Anal Bioanal Chem

      Volume: 400 Pages: 1895-904

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] ヒト化マウスの改良と疾患モデルへの応用2011

    • Author(s)
      伊藤守、末水洋志
    • Journal Title

      実験医学増刊

      Volume: 30 Pages: 300-5

    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] The reconstituted 'humanized liver' in TK-NOG mice is mature and functional2011

    • Author(s)
      Hasegawa, M., Suemizu, H.(11名・11番目)
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 405 Issue: 3 Pages: 405-410

    • DOI

      10.1016/j.bbrc.2011.01.042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] ヒト化マウスの改良と疾患モデルへの応用2011

    • Author(s)
      伊藤守・末水洋志
    • Journal Title

      実験医学増刊in vivo実験医学によるヒト疾患解明の最前線

      Volume: 30(2) Pages: 300-305

    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] Gene targeting and subsequent site-specific transgenesis at theβ-actin(ACTB) locus in common marmoset embryonic stem cells2011

    • Author(s)
      Shiozawa, S., Suemizu, H.(12名・8番目)
    • Journal Title

      Stem Cells Dev

      Volume: 20 Issue: 9 Pages: 1587-99

    • DOI

      10.1089/scd.2010.0351

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042, KAKENHI-PROJECT-21390474, KAKENHI-PROJECT-22390328, KAKENHI-PUBLICLY-23110516, KAKENHI-PROJECT-23650194, KAKENHI-PROJECT-23689017
  • [Journal Article] Vinyl Isolator Breeding Induces Insulin Resistance in C57BL/6JJcl Mice2011

    • Author(s)
      Hashimoto, H., Suemizu, H.(15名,・12番目)
    • Journal Title

      Exp. Anim.

      Volume: 60 Issue: 5 Pages: 497-508

    • DOI

      10.1538/expanim.60.497

    • NAID

      10029835491

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042, KAKENHI-PROJECT-22650095
  • [Journal Article] マウスを用いたヒト肝臓モデル2011

    • Author(s)
      末水洋志
    • Journal Title

      Surgical Frontier

      Volume: 18 Pages: 284-7

    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] ヒト化肝臓マウスモデル2011

    • Author(s)
      末水洋志
    • Journal Title

      細胞工学

      Volume: 31 Pages: 3226-30

    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] Generating induced pluripotent stem cells from common marmoset(Callithrix jacchus) fetal liver cells using defined factors, including Lin282010

    • Author(s)
      Tomioka, I., Suemizu, H.(15名・13番目)
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 959-69

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970909/?tool=pubmed

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] Comparative Study of Doses of Exogenous Progesterone Administration Needed to Delay Parturition in Jcl:MCH(ICR) Mice2010

    • Author(s)
      Hashimoto, H. Suemizu, H.(7名・6番目)
    • Journal Title

      Exp. Anim.

      Volume: 59 Issue: 4 Pages: 521-524

    • DOI

      10.1538/expanim.59.521

    • NAID

      130000298613

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] Phosphorescence-assisted microvascular 0(2) measurements reveal alterations of oxygen demand in human metastatic colon cancer in the liver of superimmunodeficient NOG mice2010

    • Author(s)
      Handa, K., Suemizu, H.(12名・7番目)
    • Journal Title

      Adv Exp Med Biol

      Volume: 662 Pages: 423-9

    • DOI

      10.1007/978-1-4419-1241-1_61

    • ISBN
      9781441912398, 9781441912411
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] NOGマウスとヒト化マウス2009

    • Author(s)
      伊藤守、末水洋志
    • Journal Title

      ファルマシア

      Volume: 45 Pages: 1077-80

    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] NOGマウスを用いたヒト化動物モデルの研究展開2009

    • Author(s)
      涌井昌俊、末水洋志
    • Journal Title

      生化学

      Volume: 82 Pages: 314-8

    • NAID

      10026301245

    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] Thrombospondin 2 inhibits metastasis of human malignant melanoma through microenvironment-modification in N0D/SCID/gammaCnull(NOG) mice2009

    • Author(s)
      Chijiwa, T., Suemizu, H.(14名・6番目)
    • Journal Title

      Int J Oncol

      Volume: 34 Pages: 5-13

    • DOI

      10.3892/ijo_00000123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] Generation of transgenic non-human primates with germline transmission2009

    • Author(s)
      Sasaki, E., Suemizu, H.(23名・2番目)
    • Journal Title

      Nature

      Volume: 459 Issue: 7246 Pages: 523-7

    • DOI

      10.1038/nature08090

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] Alternative splicing variant of vascular endothelial growth factor-A is a critical prognostic factor in non-small cell lung cancer2009

    • Author(s)
      Matsuyama, M., Suemizu, H.(12名・9番目)
    • Journal Title

      Oncol Rep

      Volume: 22 Issue: 06 Pages: 1407-13

    • DOI

      10.3892/or_00000582

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] Higher susceptibility of NOG mice to xenotransplanted tumors2009

    • Author(s)
      Machida, K., Suemizu, H.(7名・2番目)
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 34 Issue: 1 Pages: 123-127

    • DOI

      10.2131/jts.34.123

    • NAID

      110007043218

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Journal Article] Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice.2008

    • Author(s)
      Suemizu H., M.Hasegawa, K.Kawai, K.Taniguchi, M.Monnai, M.Wakui, M.Suematsu, M.Ito, G.Peltz, M.Nakamura
    • Journal Title

      Biochem Biophys Res Commun 377

      Pages: 248-252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Journal Article] Establishing EGFP congenic mice in a NOD/Shi-scid IL2Rg (null) (NOG) genetic background using a marker-assisted selection protocol (MASP)2008

    • Author(s)
      Suemizu, H.
    • Journal Title

      Exp Anim 57

      Pages: 471-477

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Journal Article] Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice2008

    • Author(s)
      Suemizu, H.
    • Journal Title

      Biochem Biophys Res Commun 377

      Pages: 248-252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Journal Article] Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice2008

    • Author(s)
      Suemizu, H., M. Hasegawa, K. Kawai, K. Taniguchi, M. Monnai, M. Wakui, M. Suematsu, M. Ito, G. Peltz, and M. Nakamura.
    • Journal Title

      Biochem Biophys Res Commun 377

      Pages: 248-252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Journal Article] Establishing EGFP congenic mice in a NOD/Shi-scid IL2Rg(null) (NOG) genetic background using a marker-assisted selection protocol (MASP).2008

    • Author(s)
      Suemizu H., C.Yagihashi, T.Mizushima, T.Ogura, T.Etoh, K.Kawai, M.Ito
    • Journal Title

      Exp Anim 57

      Pages: 471-477

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Journal Article] Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in NOD/SCID/gammacnull (NOG) mice.2007

    • Author(s)
      Suemizu H., M.Monnai, Y.Ohnishi, M.Ito, N.Tamaoki, M.Nakamura
    • Journal Title

      Int J Oncol 31

      Pages: 741-751

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Journal Article] Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in NOD/SCID/gammacnull(NOG)mice2007

    • Author(s)
      Suemizu H
    • Journal Title

      Int J Oncol 81

      Pages: 13259-64

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Journal Article] 免疫不全マウスを用いたヒトがんモデルの作製2005

    • Author(s)
      末水 洋志
    • Journal Title

      血液・腫瘍科 51(1)

      Pages: 104-112

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17300136
  • [Journal Article] S100A4 expression with reduced E-cadherin expression predicts distant metastasis of human malignant melanoma cell lines in NOD/SCID/γc^<null>(NOG) mouse model2005

    • Author(s)
      N.Ikoma, H.Yamazaki, H.Suemizu, M.Nakamaura et al.
    • Journal Title

      Oncology Reports 14

      Pages: 633-637

    • Data Source
      KAKENHI-PROJECT-16590325
  • [Journal Article] Development of human cancer model using immunodeficient mice.2005

    • Author(s)
      Suemizu H.
    • Journal Title

      Ketsueki・Shuyouka 51

      Pages: 104-112

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300136
  • [Journal Article] S100A4 expression with reduced E-cadherin expression predicts distant metastasis of human malignant melanoma cell lines in NOD/SCID/_<γ_c>^<null> (NOG) mouse model2005

    • Author(s)
      N.Ikoma, H.Yamazaki, H.Suemizu, M.Nakamura et al.
    • Journal Title

      Oncology Reports 14

      Pages: 633-637

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590325
  • [Journal Article] S100A4 expression with reduced E-cadherin expression predicts didtant metastasis of human malignant melamona cell lines in NOD/SCID/γc^<null>(NOG) mouse model2005

    • Author(s)
      N.Ikoma, H.Yamazaki, H.Suemizu, N.Nakamura et al.
    • Journal Title

      Oncology Reports 14

      Pages: 633-637

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590325
  • [Journal Article] Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in NOD/SCID/γc^<null> (NOG) mice.

    • Author(s)
      Suemizu H.
    • Journal Title

      Int J Oncol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300136
  • [Journal Article] Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in NOD/SCID/γ_c^<null> (NOG) mice.

    • Author(s)
      Suemizu H.
    • Journal Title

      Int J Oncol (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17300136
  • [Patent] ヒト肝細胞が移植されたマウス2009

    • Inventor(s)
      末水洋志、川井健司、中村雅登、長谷川雅巳
    • Industrial Property Rights Holder
      末水洋志、川井健司、中村雅登、長谷川雅巳
    • Industrial Property Number
      2009-008097
    • Filing Date
      2009-10-06
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Presentation] Studies on physiological equivalence of human hepatocytes and liver cells harvested from humanized-liver chimeric mice2019

    • Author(s)
      Hiroshi Suemizu, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, and Shotaro Uehara
    • Organizer
      Society of Toxicology 58th Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07102
  • [Presentation] Detection of Human-Specific Hepatotoxicity in Humanized-Liver Mouse Using Cytokeratin-18 ELISA and Circulating mRNA qRT-PCR2017

    • Author(s)
      Hiroshi Suemizu, Kenji Kawai, Megumi Nishiwaki, Mikiko Okazaki, Hideki Nabekawa, and Hidetaka Kamimura
    • Organizer
      The Society of Toxicology 56th Annual Meeting and ToxExpo (SOT 2017)
    • Place of Presentation
      米国メリーランド州ボルチモア
    • Year and Date
      2017-03-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07102
  • [Presentation] Use of Cytokeratin-18 ELISA to Detect Human Specific Hepatotoxicity in the Humanized-Liver Mouse2017

    • Author(s)
      Hiroshi Suemizu, Nao Yoneda, Kenji Kawai and Riichi Takahashi
    • Organizer
      EutoTox 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07102
  • [Presentation] Antibody-Secreting B Cells are Directly Developed from Transitional B cells of Humanized NOG Mice.2013

    • Author(s)
      Kametani, Y., Mori, S., Shimada, S., Oshima, S., Aokawa, J., Okada, Y., Goto, Y., Tsuda, B., Yahata, T., Ito, R., Katano, I., Suemizu, H., Ito, M., Habu, S. and Ando, K.
    • Organizer
      第4回国際ヒト化マウスワークショップ
    • Place of Presentation
      ソウル
    • Data Source
      KAKENHI-PROJECT-22220007
  • [Presentation] The human hepatic cell line HepaRG® as a possible cell source for the steady generation of humanized liver TK-NOG mice2013

    • Author(s)
      Hiroshi Suemizu, Yuichiro Higuchi, Kenji Kawai, Hiroshi Yamazaki, Françoise Bree, Christiane Guguen-Guillouzo, and Masato Nakamura
    • Organizer
      4th International Workshop on Humanized Mice
    • Place of Presentation
      韓国、ソウル
    • Data Source
      KAKENHI-PROJECT-25640055
  • [Presentation] ヒト肝移植マウスを用いたアセフェートの代謝消失2012

    • Author(s)
      清水万紀子、末水洋志
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Presentation] K-NOGマウスを用いた機能性'ヒト化肝臓'の作製2011

    • Author(s)
      末水洋志
    • Organizer
      日本実験動物学会第58回総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-26
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Presentation] NOGマウスを用いたヒト化肝臓モデルの確立2009

    • Author(s)
      末水洋志
    • Organizer
      第56回日本実験動物学会総会
    • Place of Presentation
      大宮・埼玉県
    • Year and Date
      2009-05-15
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Presentation] Establishing a humanized model of the liver using NOG mice2009

    • Author(s)
      末水洋志
    • Organizer
      International Workshop on Humanized Mice第2回大会
    • Place of Presentation
      オランダ
    • Year and Date
      2009-04-04
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Presentation] Establishing a humanized model of the liver using NOG mice2009

    • Author(s)
      長谷川雅巳、末水洋志
    • Organizer
      The International Society for Stem Cell Research(ISSCR)第7回大会
    • Year and Date
      2009-07-09
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Presentation] Establishing a humanized model of the liver using NOG mice2009

    • Author(s)
      末水洋志
    • Organizer
      2nd International Workshop on Humanized Mice(IWHM II)
    • Place of Presentation
      アムステルダム・オランダ
    • Year and Date
      2009-04-05
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Presentation] Establishing a humanized model of the liver using NOG mice2009

    • Author(s)
      Suemizu H
    • Organizer
      2^<nd> IWHM
    • Place of Presentation
      Holland
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Presentation] ヒトガン転移モデル(ヒト化動物の現状と今後)(シンポジウム)2009

    • Author(s)
      末水洋志
    • Organizer
      第56回日本実験動物学会総会
    • Place of Presentation
      大宮・埼玉県
    • Year and Date
      2009-05-15
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Presentation] NOGマウスを用いたヒト化肝臓モデルの確立2009

    • Author(s)
      末水洋志
    • Organizer
      日本実験動物学会第56回総会
    • Place of Presentation
      大宮
    • Year and Date
      2009-05-14
    • Data Source
      KAKENHI-PROJECT-21240042
  • [Presentation] NOGマウスを用いたヒト肝臓モデルの確立2009

    • Author(s)
      末水洋志
    • Organizer
      第56回日本実験動物学会総会
    • Place of Presentation
      大宮
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Presentation] In vitro Chemosensitivity of human glioma stem cells compared with that of nomal neural stem cells from human iPS cells.

    • Author(s)
      Kanemura Y, Shofuda T, Kanematsu D, Matsumoto Y, Yamamoto A, Nonaka M, Moriuchi S, Nakajima S, Suemizu H, Nakamura M, Okada Y, Okano H, Yamasaki M.
    • Organizer
      ISSCR 10th Annual Meeting
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-24592181
  • [Presentation] ヒトIL=5遺伝子導入型NOGマウスのヒト好酸球分化能の解析

    • Author(s)
      片野いくみ、高橋武司、伊藤亮治、上迫努、何裕遥、小倉智幸、高橋利一、末水洋志、河上裕、伊藤守
    • Organizer
      第61回日本実験動物学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2014-05-15 – 2014-05-17
    • Data Source
      KAKENHI-PROJECT-22220007
  • [Presentation] TK-NOGマウスの計画生産および特性データ

    • Author(s)
      富山香代、小倉智幸、何裕遥、上迫努、高橋利一、伊藤守、日置恭司、末水洋志
    • Organizer
      第61回日本実験動物学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2014-05-15 – 2014-05-17
    • Data Source
      KAKENHI-PROJECT-22220007
  • 1.  NAKAMURA Masato (00164335)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 2.  ITO Mamoru (00176364)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 10 results
  • 3.  ANDO Kiyoshi (70176014)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  HABU Sonoko (30051618)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  MIYAKAWA Yoshitaka (50250238)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  SUZUE Kazutomo (00333485)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KOYANAGI Yoshio (80215417)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KAMETANI Yoshie (50338787)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  TAKAHASI Takeshi (80335215)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 10.  NAKAHATA Tatsutoshi (20110744)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YAHATA Takashi (10398753)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  ETO Tomoo (30370175)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  TANOUE Akito (60301800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 14.  NAKAMURA Kazuaki (80392356)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  IKEJIMA Kenichi (20317382)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  YAMASHINA Shunhei (30338412)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  KON Kazuyoshi (30398672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KANEMURA Yonehiro (80344175)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  SHOFUDA Tomoko (40450895)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  OKANO Hideyuki (60160694)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 21.  OKADA Yohei (30383714)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 22.  TSUNODA Tatsuhiko (10273468)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  MIYA Fuyuki (50415311)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  OHNISHI Yasuyuki (70201382)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  TOMISAWA Masashi (10321663)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  ITOH Kikuji (50100045)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  HIRAYAMA Kazuhiro (60208858)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  YAMAZAKI Hitoshi (20191273)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 29.  KATOH Hideki (30142053)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  TAKABAYASHI Shuji (70372521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  NISHIKAWA Tetsu (50260584)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  TANIOKA Yoshikuni (10072406)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  ITO Ryoji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 34.  KATANO Ikumi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results

URL: 

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi