KAWAKAMI Toshiaki 川上敏明

… Alternative Names

川上敏明カワカミトシアキ

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Researcher Number	60143418
Other IDs
Affiliation (based on the past Project Information) *help	2017: 理化学研究所, 統合生命医科学研究センター, チームリーダー 2015: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー 2013 – 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー 1988 – 1989: 京都大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Collagenous pathology/Allergology Except Principal Investigator Otorhinolaryngology / Pediatrics
Keywords	Principal Investigator TSLP / Periostin / Stat5 / Phospholipase C-β3 / マスト細胞 / アトピー性皮膚炎 Except Principal Investigator IgE / マスト細胞 / ヒスタミン遊離因子（HRF) / 好塩基球 … More / HRF / アレルギー性鼻炎 / 花粉症 / エンハンサー / インターロイキン5 / インターロイキン2の受容体 / 人工突然変異 / リンフォカイン遺伝子 / 免疫グロブリン遺伝子 / IL-5遺伝子 / IL-4遺伝子 / 染色体マップ / トランスジェーニックマウス / IL-2リセプター / IL-4 / Bリンパ球の分化 / 抗体遺伝子D断片 / NK細胞 / トランスジュニックマウス / IL-2R / IL-2 / IgM^+IgG^+B細胞 / クラススイッチ / 骨髄細胞からのリンパ球への分化 / ヒト抗体V_H鎖遺伝子 / trans splicing / double isotype expression / transgenic mouse / integrase family / cDNAクローニング / DNA結合タンパク質 / 抗体遺伝子再構成 / 環状DNA / SーS組換え / ショウジョウバエ / リコンビナ-ゼ / ストロ-マ細胞 / 骨髄多分化能細胞 / VDJ組換 / Bリンパ球 / 高親和性IgE受容体 / ヒスタミン遊離因子(HRF) / 急速経口免疫療法(ROIT) / HRF反応性IgE / 食物アレルギー / 遺伝子導入 / マウス赤白血病細胞 / cーmyb / cーmyc / 癌遺伝子 / 分化の決定 / 細胞分化 Less

The role of HRF in pollinosis
- Principal Investigator
  
  KASHIWAKURA Jun-ichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Hokkaido University
  Institute of Physical and Chemical Research
Pathogenic mechanisms of atopic dermatitisPrincipal Investigator
- Principal Investigator
  
  Kawakami Toshiaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Institute of Physical and Chemical Research
Investigation of HRF-mediated amplifying mechanism in food allergy
- Principal Investigator
  
  KASHIWAKURA Jun-ichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  The Institute of Physical and Chemical Research
細胞分化のプログラミングと癌遺伝子
- Principal Investigator
  
  帯刀益夫
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
免疫系における多様性発現機構の分子遺伝学的研究
- Principal Investigator
  
  本庶佑
- Project Period (FY)
  1986 – 1990
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Kyoto University

All 2018 2017 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] A Mouse Model of Atopic Dermatitis. In Mast Cells: Methods and Protocols,Methods in Molecular Biology vol. 1220, (eds. Michael R. Hughes and Kelly M. McNagny)2015
- Author(s)
  Kawakami, Y. and Kawakami, T
- Total Pages
  540
- Publisher
  Springer Science+Business Media
- Data Source
  KAKENHI-PROJECT-25253071
[Book] 臨床免疫・アレルギー科2015
- Author(s)
  柏倉淳一、安藤智暁、川上敏明
- Total Pages
  5
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-25670483
[Book] 化学と生物2014
- Author(s)
  柏倉淳一、安藤智暁、川上敏明
- Total Pages
  3
- Publisher
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-25670483
[Book] Basic Techniques to Study FcεRI Signaling in Mast Cells. In Mast Cells: Methods and Protocols, Methods in Molecular Biology vol. 1220, (eds. Michael R. Hughes and Kelly M. McNagny)2014
- Author(s)
  Kawakami, Y. and Kawakami, T.
- Total Pages
  540
- Publisher
  Springer Science+Business Media
- Data Source
  KAKENHI-PROJECT-25253071
[Journal Article] Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation2018
- Author(s)
  Dore Katy A.、Kashiwakura Jun-ichi、McDonnell James M.、Gould Hannah J.、Kawakami Toshiaki、Sutton Brian J.、Davies Anna M.
- Journal Title
  
  Molecular Immunology
  
  Volume: 93 Pages: 216-222
- DOI
  10.1016/j.molimm.2017.11.022
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10794
[Journal Article] Role of Histamine-releasing Factor in Allergic Inflammatory Reactions2017
- Author(s)
  柏倉淳一、安藤智暁、川上敏明
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 5 Pages: 517-521
- DOI
  10.1248/yakushi.16-00239-3
- NAID
  130005631392
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-05-01
- Language
  Japanese
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10794
[Journal Article] Histamine-releasing factor enhances food allergy2017
- Author(s)
  Ando Tomoaki、Kashiwakura Jun-ichi、Itoh-Nagato Naoka、Yamashita Hirotaka、Baba Minato、Kawakami Yu、Tsai Shih Han、Inagaki Naoki、Takeda Kiyoshi、Iwata Tsutomu、Shimojo Naoki、Fujisawa Takao、Nagao Mizuho、Matsumoto Kenji、Kawakami Yuko、Kawakami Toshiaki
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 127 Issue: 12 Pages: 4541-4553
- DOI
  10.1172/jci96525
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10794
[Journal Article] Hypothetical atopic dermatitis-myeloproliferative neoplasm syndrome.2015
- Author(s)
  Kawakami, T., Ando, T., and Kawakami, Y.
- Journal Title
  
  Front. Immunol.
  
  Volume: 6 Pages: 434-434
- DOI
  10.3389/fimmu.2015.00434
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253071, KAKENHI-PROJECT-26860765
[Journal Article] アトピー性皮膚炎におけるマスト細胞のStat5活性化経路の関与2015
- Author(s)
  安藤智暁，川上敏明
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: in press
- NAID
  40020505178
- Data Source
  KAKENHI-PROJECT-25253071
[Journal Article] アレルギー疾患におけるヒスタミン遊離因子の関与2015
- Author(s)
  柏倉淳一, 安藤智暁, 川上敏明
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 63 Pages: 84-88
- NAID
  40020330518
- Data Source
  KAKENHI-PROJECT-25253071
[Journal Article] Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation.2015
- Author(s)
  Carroll-Portillo, A., Cannon, J.L., te Riet, J., Holmes, A., Kawakami, Y., Kawakami, T., Cambi, A., and Lidke, D.S.
- Journal Title
  
  J. Cell Biol.
  
  Volume: 210 Issue: 5 Pages: 851-864
- DOI
  10.1083/jcb.201412074
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253071
[Journal Article] Signal transduction and chemotaxis in mast cells2015
- Author(s)
  Draber, P., Halova, I., Polakovicova, I., and Kawakami, T.
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253071
[Journal Article] Signal transduction and chemotaxis in mast cells.2015
- Author(s)
  Draber, P., Halova, I., Polakovicova, I., and Kawakami, T.
- Journal Title
  
  Eur. J. Pharmacol.
  
  Volume: 778 Pages: 11-23
- DOI
  10.1016/j.ejphar.2015.02.057
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253071
[Journal Article] アレルギー炎症とIgE Heterogeneityヒスタミン遊離因子によるマスト細胞活性化調節2014
- Author(s)
  柏倉淳一, 安藤智暁, 川上敏明
- Journal Title
  
  化学と生物
  
  Volume: 52 Pages: 496-498
- NAID
  130005090119
- Data Source
  KAKENHI-PROJECT-25253071
[Journal Article] Histamine-releasing factor and immunoglobulins in asthma and allergy2014
- Author(s)
  Kawakami, T., Kashiwakura, J., and Kawakami, Y.
- Journal Title
  
  Allergy, Asthma & Immunology Research
  
  Volume: 6 Issue: 1 Pages: 6-12
- DOI
  10.4168/aair.2014.6.1.6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253071, KAKENHI-PROJECT-25670483
[Journal Article] Immune regulation by phospholipase C-βisoforms.2013
- Author(s)
  Xiao, W., Kawakami, Y., and Kawakami, T.
- Journal Title
  
  Immunol. Res.
  
  Volume: 56 Issue: 1 Pages: 9-19
- DOI
  10.1007/s12026-012-8341-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253071
[Journal Article] Critical role for mast-cell Stat5 activity in skin inflammation.2013
- Author(s)
  Ando, T., Xiao, W., Gao, P., Namiranian, S., Matsumoto, K., Tomimori, Y., Hong, H., Yamashita, H., Kimura, M., Kashiwakura, J., Hata, T.R., Izuhara, K., Gurish, M.F., Roers, A., Rafaels, N.M., Barnes, K.C., Jamora, C., Kawakami, Y., and Kawakami, T.
- Journal Title
  
  Cell Reports
  
  Volume: 6 Issue: 2 Pages: 366-376
- DOI
  10.1016/j.celrep.2013.12.029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253071, KAKENHI-PROJECT-25293224
[Journal Article] Mast cells are required for full expression of allergen/SEB-induced skin inflammation.2013
- Author(s)
  Ando, T., Matsumoto, K., Namiranian, S., Yamashita, H., Glatthorn, H., Kimura, M., Dolan, B. R., Lee, J.J., Galli, S.J., Kawakami, Y., Jamora, C., and Kawakami, T.
- Journal Title
  
  J. Invest. Dermatol.
  
  Volume: 133 Issue: 12 Pages: 2695-2705
- DOI
  10.1038/jid.2013.250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253071
[Journal Article] Salmonella’s masterful skill in mast cell suppression.2013
- Author(s)
  Kawakami, T. and Ando, T.
- Journal Title
  
  Immunity
  
  Volume: 39 Issue: 6 Pages: 996-998
- DOI
  10.1016/j.immuni.2013.11.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253071
[Journal Article] ヒスタミン遊離因子（HRF）によるアレルギー炎症増悪メカニズム2013
- Author(s)
  柏倉淳一、川上裕子、川上敏明
- Journal Title
  
  アレルギー・免疫
  
  Volume: 20 Pages: 30-37
- Data Source
  KAKENHI-PROJECT-25670483
[Presentation] Histamine-releasing factor in food allergy.2015
- Author(s)
  Kawakami, T.
- Organizer
  The 7th EMBRN International Mast Cell and Basophil Meeting
- Place of Presentation
  Marseille, France
- Year and Date
  2015-10-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253071
[Presentation] Phospholipase C-β3 in the defense against skin inflammation.2015
- Author(s)
  Kawakami, T.
- Organizer
  SPC-NUS Workshop “Mast cells in immune disorders and tissue homeostasis
- Place of Presentation
  Paris, France.
- Year and Date
  2015-10-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253071
[Presentation] Atopic dermatitis and hematopoietic malignancy: Lessons from studies on2014
- Author(s)
  Kawakami, T.
- Organizer
  The 14th Annual Meeting of The Korean Atopic
- Place of Presentation
  Seoul, Republic of Korea
- Year and Date
  2014-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-25253071
[Presentation] Critical role for mast-cell Stat5 activity in atopic dermatitis2014
- Author(s)
  Kawakami, T.
- Organizer
  The LJI-USC Immunology Retreat
- Place of Presentation
  La Jolla, California, USA
- Year and Date
  2014-04-22
- Invited
- Data Source
  KAKENHI-PROJECT-25253071
[Presentation] Mast cells and the Stat5 activation pathway are required for allergen-induced and spontaneous skin inflammation2014
- Author(s)
  Tomoaki Ando, Jun-ichi Kashiwakura, Yuko Kawakami, Toshiaki Kawakami
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館、京都市
- Year and Date
  2014-12-11
- Data Source
  KAKENHI-PROJECT-25253071
[Presentation] Phospholipase C-β3 as a tumor suppressor and a guardian of the immune system
- Author(s)
  Toshiaki Kawakami
- Organizer
  The 5th LIAI-IMS Workshop
- Place of Presentation
  Yokohama, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-25253071
[Presentation] Breakfast Seminar entitled “New insights into IgE biology”
- Author(s)
  Toshiaki Kawakami
- Organizer
  The Annual Meeting of American Academy of Allergy, Asthma and Immunology
- Place of Presentation
  San Diego, California, USA
- Invited
- Data Source
  KAKENHI-PROJECT-25253071
[Presentation] Phospholipase C-β3 as a tumor suppressor and a guardian of the immune system
- Author(s)
  Toshiaki Kawakami
- Organizer
  Special International Symposium “Inositide-Dependent Phospholipase C Activity and Signalling”
- Place of Presentation
  Ulsan, South Korea
- Invited
- Data Source
  KAKENHI-PROJECT-25253071
[Presentation] Critical role for mast-cell Stat5 activity in atopic dermatitis
- Author(s)
  Kawakami, T.
- Organizer
  Academy of Immunology and Microbiology (AIM) Workshop on Immunology 2014
- Place of Presentation
  Pohang, Republic of Korea
- Year and Date
  2014-11-09 – 2014-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-25253071
[Presentation] Phospholipase C-β3 as a tumor suppressor and a guardian of the immune system
- Author(s)
  Toshiaki Kawakami
- Organizer
  2013 International Conference “Inflammation,Cancer and Metabolic Disorders”
- Place of Presentation
  Zhunan, Miaoli, Taiwan
- Invited
- Data Source
  KAKENHI-PROJECT-25253071
[Presentation] Stat5 regulation: a crucial mediator in mast cell-dependent skin inflammation
- Author(s)
  Toshiaki Kawakami
- Organizer
  The 7th International Leukocyte Signal Transduction Conference
- Place of Presentation
  Kos, Greece
- Invited
- Data Source
  KAKENHI-PROJECT-25253071

1. KASHIWAKURA Jun-ichi (90373290)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. ANDO Tomoaki (10724669)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. Izuhara Kenji (00270463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Matsumoto Kenji (60181765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. TAKEMORI TOSHITAda (60114295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 帯刀益夫 (10099971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 林健志 (00019671)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 野田亮 (30146708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 石井俊輔 (00124785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大石道夫 (00126004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 本庶佑 (80090504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 清水章 (00162694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 川市正史 (00195041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 佐辺寿孝 (40187282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 松浪伯禎 (40192752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 木梨達雄 (30202039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 野間隆文 (40189428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 武田俊一 (60188191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KAWAKAMI Toshiaki 川上 敏明

川上 敏明 カワカミ トシアキ

Research Projects

Research Products

Co-Researchers

The role of HRF in pollinosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenic mechanisms of atopic dermatitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of HRF-mediated amplifying mechanism in food allergy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞分化のプログラミングと癌遺伝子

Principal Investigator

Project Period (FY)

Research Category

Research Institution

免疫系における多様性発現機構の分子遺伝学的研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] A Mouse Model of Atopic Dermatitis. In Mast Cells: Methods and Protocols,Methods in Molecular Biology vol. 1220, (eds. Michael R. Hughes and Kelly M. McNagny)2015

Author(s)

Total Pages

Publisher

Data Source

[Book] 臨床免疫・アレルギー科2015

Author(s)

Total Pages

Publisher

Data Source

[Book] 化学と生物2014

Author(s)

Total Pages

Publisher

Data Source

[Book] Basic Techniques to Study FcεRI Signaling in Mast Cells. In Mast Cells: Methods and Protocols, Methods in Molecular Biology vol. 1220, (eds. Michael R. Hughes and Kelly M. McNagny)2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Histamine-releasing Factor in Allergic Inflammatory Reactions2017

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Histamine-releasing factor enhances food allergy2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypothetical atopic dermatitis-myeloproliferative neoplasm syndrome.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] アトピー性皮膚炎におけるマスト細胞のStat5活性化経路の関与2015

Author(s)

Journal Title

KAWAKAMI Toshiaki 川上敏明

川上敏明カワカミトシアキ