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Ohtsuki Sumio  大槻 純男

… Alternative Names

OHTSUKI Sumio  大槻 純男

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Researcher Number 60323036
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-4634-7133
External Links
Affiliation (Current) 2025: 熊本大学, 大学院生命科学研究部(薬), 教授
Affiliation (based on the past Project Information) *help 2014 – 2024: 熊本大学, 大学院生命科学研究部(薬), 教授
2017: 熊本大学, 薬学部, 教授
2016: 熊本大学, その他の研究科, 教授
2014 – 2016: 熊本大学, 大学院生命科学研究部, 教授
2015: 熊本大学, 生命科学研究部, 教授 … More
2015: 熊本大学, 生命科学研究部薬学系, 教授
2013: 熊本大学, 薬学部, 教授
2011: Tohoku University, 薬学研究科(研究院), 准教授
2011: 熊本大学, 生命科学研究部, 教授
2009 – 2010: 東北大学, 薬学研究科, 准教授
2007 – 2010: Tohoku University, 大学院・薬学研究科, 准教授
2006: Tohoku University, Graduate School of Pharmaceutical Sciences, Associate Professor, 大学院薬学研究科, 助教授
2003 – 2005: 東北大学, 大学院・薬学研究科, 助教授
2000 – 2002: 東北大学, 大学院・薬学研究科, 講師 Less
Review Section/Research Field
Principal Investigator
Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Transformative Research Areas, Section (III) / Tumor diagnostics / Complex systems / 応用薬理学・医療系薬学
Except Principal Investigator
Basic Section 47060:Clinical pharmacy-related / Medical pharmacy / 応用薬理学・医療系薬学 / Basic Section 43050:Genome biology-related … More / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Transformative Research Areas, Section (III) / Medium-sized Section 50:Oncology and related fields / Neurosurgery / Tumor diagnostics / Pediatrics / 医薬分子機能学 / Psychiatric science / Complex systems / Digestive surgery / Biological Sciences Less
Keywords
Principal Investigator
プロテオミクス / トランスポーター / 血液脳関門 / 脳毛細血管 / 脳関門 / DDS / 輸送 / 内在化 / 質量分析 / 膜タンパク質 … More / クレアチン / 細胞外マトリックス / 脱細胞化マトリックス / 微粒子 / 液性因子 / 細胞外マトリクス / プロテミクス / 脱細胞化マトリクス / 種差 / 膜輸送 / ペプチド / 透過 / 小腸 / Caco2細胞 / Caco-2細胞 / 小腸透過 / 環状ペプチド / Regulation / Disease / Cholesterol / ABC transporter / Efflux transport / Neurotoxin / Blood-Cerebrospinal Fluid Barrier / Blood-Brain Barrier / 脳内局在 / キノリン酸 / 脳脊髄液関門 / ABCG2 / ABCA1 / 制御 / 病態 / コレステロール / ABCトランスポーター / 排出輸送 / 神経毒 / 血液脳脊髄液関門 / プロテオーミクス / データベース / 溶出時間 / 中秋疾患 / 中枢疾患 / 細胞内局在 / クレアチン欠乏症 / 肝臓 / メタボロミクス / UGT / CYP / 絶対量 / 代謝酵素 / 定量プロテオミクス / タンパク質 / 細胞膜 / 定量的プロテオミクス / 薬学 / インフォマティックス / 培養細胞 / 血管内皮細胞 / 脳分布 / 単分子活性 / MS / LC-MS / P-糖タンパク質 / 輸送担体 / 神経保護 / エネルギー貯蓄 / 中枢神経疾患 / 輸送単体 … More
Except Principal Investigator
プロテオミクス / バイオマーカー / 血液脳関門 / 質量分析 / 脳毛細血管内皮細胞 / トランスポーター / 膠芽腫 / iPS細胞 / アルツハイマー病 / 個別化医療 / CYLD / エクソソーム / 血液 / conditionally immortalized cell line / blood-brain barrier / 条件的不死化細胞 / 輸送担体 / 細胞膜輸送 / 脳脊髄液 / ABCトランスポーター / siRNA / 効果予測マーカー / 分子診断 / 分子標的治療 / 1細胞オミクス / 高感度分析 / 油中液滴 / 自動化 / ハイスループット / 1細胞 / ドラックデリバリーシステム / トランスサイトーシス / マクロピノサイトーシス / 組織関門 / 細胞膜透過ペプチド / マクロファージ / 脂肪化 / 炎症 / 脳機能 / 予後判定 / 早期診断 / 血液バイオマーカー / 広報 / 若手支援 / 研究資源共有化 / 技術支援 / 細胞外マトリックス / 薬剤耐性 / コピー数 / 肺がん / 細胞死 / がん抑制遺伝子 / オートファジー / ゲノム / コピー数変化 / MYC / コピー数減少 / コピー数変異 / オートファジ― / BAX / ゲノム不安定性 / 抗がん剤耐性 / BHLHE41 / 遺伝子増幅 / 薬剤感受性 / 分子標的治療薬 / 神経細胞 / 糖鎖 / 早期バイオマーカー / グリオーマ / 自閉症 / 精神遅滞 / グアニジノ酢酸 / クレアチニン / グアニジノ化合物 / 発達障害 / クレアチントランスポーター / 治療薬 / 脳クレアチン欠乏症候群 / 先天性代謝異常 / クレアチン / 知的障害 / インスリン抵抗性 / タンパク質翻訳後修飾 / O-グリコシル化 / p53 / 細胞浸潤 / 細胞増殖 / 定量プロテオーム解析 / がん / 細胞老化 / オーファントランスポーター / Efflux transport / Energy / Protection / Regulation / Neural disorders / Transporter / Brain capilary endothelial cells / Blood-brain barrieer / basic FGF / 脳内エネルギー蓄積物質 / クレアチン輸送系 / system A / system Xc^- / 酸化的ストレス / organic anion transporter3(OAT3) / ASCT / 立体選択性 / アルパラギン酸輸送 / 有機アニオン輸送系 / アミロイド蛋白 / Tie2受容体 / アンジオポエチン / 密着結合 / 周皮細胞 / Oatp / Oat / 尿毒症 / 有機アニオン輸送 / 排出輸送 / 脳内エネルギー / 中枢防御 / 制御 / 中枢疾患 / membrane transporter / drug screening / brain capillary endothelial cells / culture cell / gene expression / plasma membrane / 新薬スクリーニング / 培養細胞 / 遺伝子発現系 / brain capillary endothelial cell / central nervous system detoxification / cDNA cloning / organic anion transporter / neurotransmitter / membrane transport / 中枢解毒 / 遺伝子クローニング / 神経伝達物質 / アミロイド / アミロイドベータ / レクチン / LC-MSMS / LC-MS/MS / 死後脳 / 死後脳研究 / 統合失調症 / 生物学 / 生物物理 / 薬物動態学 / 代謝 / 全身循環 / 薬物動態 / 不整脈 / 心臓 / 生物物理学 / 生理学 / システム生物学 / メタボロミクス / 抗癌剤 / 膵癌 / 膵臓外科学 / 磁気分離 / 生理機能 / MRP / ファーマコプロテオミクス / 脳毛細血管 / 標的絶対プロテオミクス / pharmacoproteomics / ABC transporter / High Throughput Screenint / MIANS / MRP4 / 基質認識 / 薬物分布 / 蛍光消光法 / ApoE / リポタンパク質 / 24-S-水酸化コレステロール / コレステロール / 脂質代謝 / OAT / GLUT1 / LRP-1 / ABCG2 / oatp2 / Mct1 / P-gp / LXR / P-糖蛋白質 / 膜輸送複合体 / トランスポートソーム / 血液脳脊髄液関門 Less
  • Research Projects

    (36 results)
  • Research Products

    (316 results)
  • Co-Researchers

    (83 People)
  •  Construction of a brain barrier species difference map and elucidation of counterpart molecules by high depth proteomics.Principal Investigator

    • Principal Investigator
      大槻 純男
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kumamoto University
  •  Elucidation of the mechanism of macrophage function decline due to high-fat diet loading

    • Principal Investigator
      吉田 優
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      University of Hyogo
  •  領域研究「細胞外情報を統御するマルチモーダルECM」の統括と運営

    • Principal Investigator
      藤原 裕展
    • Project Period (FY)
      2023 – 2027
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Institute of Physical and Chemical Research
  •  Development and application of ECM information analysis using decellularized matrix and proteomics.Principal Investigator

    • Principal Investigator
      大槻 純男
    • Project Period (FY)
      2023 – 2027
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Kumamoto University
  •  Establishing novel molecular-targeted cancer therapies based on tumor suppressor CYLD dependent tumor transformation

    • Principal Investigator
      城野 博史
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kumamoto University
  •  Molecular basis of blood biomarkers inducing fundamental innovation in glioblastoma medicine

    • Principal Investigator
      中田 光俊
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Kanazawa University
  •  Identification of macrotranscytosis based on clarification of the molecular mechanism of transport of tissue barrier penetrating peptides

    • Principal Investigator
      伊藤 慎悟
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kumamoto University
  •  Development of high-throughput single-cell proteomics system

    • Principal Investigator
      増田 豪
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43050:Genome biology-related
    • Research Institution
      Keio University
  •  New molecular mechanisms for membrane-mediated transcellular transport across the blood brain barrierPrincipal Investigator

    • Principal Investigator
      Ohtsuki Sumio
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kumamoto University
  •  Approach to regulatory mechanism of copy number variation the gene amplified.

    • Principal Investigator
      Tatsuhiko Furukawa
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Kagoshima University
  •  Diagnosis of Alzheimer's disease by plasma

    • Principal Investigator
      Shirotani Keiro
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Nagasaki University
  •  Mcrotransport of the blood-brain barrier and its application to the permeable carrier.Principal Investigator

    • Principal Investigator
      OHTSUKI Sumio
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kumamoto University
  •  Establishing novel molecular-targeted cancer therapies based on molecular diagnostics focusing on prognostic factor CYLD

    • Principal Investigator
      Jono Hirofumi
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kumamoto University
  •  Regulation mechanism of cell senescence by orphan transporter

    • Principal Investigator
      ITO Shingo
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kumamoto University
  •  Elucidation of pemeable mechanism of new intestinal permeable peptidePrincipal Investigator

    • Principal Investigator
      OHTSUKI Sumio
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Kumamoto University
  •  Exploration of blood biomarker for glioblastoma

    • Principal Investigator
      Nakada Mitsutoshi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurosurgery
    • Research Institution
      Kanazawa University
  •  Identification of the biomarker in cerebrospinal fluid of glioblastoma by innovative proteomics

    • Principal Investigator
      Furuta Takuya
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor diagnostics
    • Research Institution
      Kurume University
      Kanazawa University
  •  Mechanism of cellular localization of mutated creatine transporter toward therapy for creatine deficiency syndromesPrincipal Investigator

    • Principal Investigator
      Ohtsuki Sumio
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kumamoto University
  •  Study on biomarkers of Alzheimer's disease for personalized medicine

    • Principal Investigator
      SHIROTANI Keiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Nagasaki University
  •  Ultra-deep quantitative proteomics with RT-normalized peptide databasePrincipal Investigator

    • Principal Investigator
      Ohtsuki Sumio
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor diagnostics
    • Research Institution
      Kumamoto University
  •  Study for Pathogenesis of Cerebral Creatine Deficiency Syndromes

    • Principal Investigator
      WADA Takahito
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Global and target-oriented proteomic analysis in the postmortem brains from patients with schizophrenia

    • Principal Investigator
      KUNII Yasuto
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Fukushima Medical University
  •  Establishment of Integrative Multi-level Systems Biology and its Applications

    • Principal Investigator
      KURACHI YOSHIHISA
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Osaka University
  •  小分子生体内挙動を制御する因子の組織・臓器階層における網羅的解析Principal Investigator

    • Principal Investigator
      大槻 純男
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Tohoku University
  •  標的オミクス融合による新しい薬物トランスポーター解析戦略の構築Principal Investigator

    • Principal Investigator
      大槻 純男
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  The prediction to overcome the drug resistance in pancreatic cancers by proteomics and metaboromics.

    • Principal Investigator
      MOTOI Fuyuhiko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University
  •  バイオインフォマティックスとプロテオミクスを駆使した新規薬物輸送担体の同定戦略Principal Investigator

    • Principal Investigator
      大槻 純男
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  Prediction of drug distribution into the brain by the model with intrinsic transporter activityPrincipal Investigator

    • Principal Investigator
      OHTSUKI Sumio
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  PROTEOMICS-BASED ANALYSIS OF BLOOD-BRAIN BARRIER TRANSPORT SYSTEM

    • Principal Investigator
      TERASAKI Tetsuya (TETSUYA Terasaki)
    • Project Period (FY)
      2006 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  Physiological role of the blood-brain barrier transportsome

    • Principal Investigator
      TERASAKI Tetsuya
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  蛍光標識化MRP4/ABCC4を用いた新薬スクリーニング系の開発

    • Principal Investigator
      寺崎 哲也
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  Analysis of blood-brain barrier transport system as the CNS elimination system for neurotoxinsPrincipal Investigator

    • Principal Investigator
      OHTSUKI Sumio
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  Physiological study on the transport functions at the blood-brain barrier relating to neural disorders.

    • Principal Investigator
      TERASAKI Tetsuya
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
  •  脳関門を介したクレアチンの脳移行メカニズムの解明Principal Investigator

    • Principal Investigator
      大槻 純男
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
  •  cDNA cloning of blood-brain barrier neurotransmitter transporter and analysis of its physiological function

    • Principal Investigator
      TERASAKI Tetsuya
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
  •  Development of new drug screening system using the blood-brain barrier transporter gene expression

    • Principal Investigator
      TERASAKI Tetsuya
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Tohoku University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book Patent

  • [Book] 血液脳関門、血液脳脊髄液関門、「分子薬物動態学」2008

    • Author(s)
      大槻純男
    • Total Pages
      14
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Book] A novel relationship between creatine transport at the blood-brain and blood-retinal barriers, Creatine biosynthesis, and its use for brain and retinal energy homeostasis2007

    • Author(s)
      M. Tachikawa, K. Hosoya, S. Ohtsuki, T. Terasaki
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Book] 血液脳関門の輸送機構と脳支援・防御システムとしての生理的役割、脳室とその周囲器官、[神経科学の基礎と臨床シリーズ11巻]2002

    • Author(s)
      大槻純男
    • Total Pages
      23
    • Publisher
      ブレーン出版
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Logistics and distribution of small extracellular vesicles from the subcutaneous space to the lymphatic system2023

    • Author(s)
      Sakurai Yu、Ohtani Asa、Nakayama Yuka、Gomi Masaki、Masuda Takeshi、Ohtsuki Sumio、Tanaka Hiroki、Akita Hidetaka
    • Journal Title

      Journal of Controlled Release

      Volume: 361 Pages: 77-86

    • DOI

      10.1016/j.jconrel.2023.07.043

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22H05546, KAKENHI-PROJECT-23K23867
  • [Journal Article] <scp>SETD1A</scp> function in leukemia is mediated through interaction with mitotic regulators <scp>BuGZ</scp>/<scp>BUB3</scp>2023

    • Author(s)
      Perlee Sarah、Kikuchi Sota、Nakadai Tomoyoshi、Masuda Takeshi、Ohtsuki Sumio、Matsumoto Makoto、Rahmutulla Bahityar、Fukuyo Masaki、Cifani Paolo、Kentsis Alex、Roeder Robert G、Kaneda Atsushi、Hoshii Takayuki
    • Journal Title

      EMBO reports

      Volume: 24 Issue: 10 Pages: 1-19

    • DOI

      10.15252/embr.202357108

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07161, KAKENHI-PROJECT-22K07164, KAKENHI-PUBLICLY-22H05546, KAKENHI-PROJECT-23K23867, KAKENHI-PROJECT-23K24359
  • [Journal Article] Effect of antibiotic-administration period on hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries2023

    • Author(s)
      Yagi Ryotaro、Masuda Takeshi、Ito Shingo、Ohtsuki Sumio
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 50 Pages: 100494-100494

    • DOI

      10.1016/j.dmpk.2023.100494

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22H05546, KAKENHI-PLANNED-23H04937, KAKENHI-PROJECT-21H02649, KAKENHI-PROJECT-23K23867
  • [Journal Article] Proteomic alterations in the brain and blood?brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease2023

    • Author(s)
      Ito Shingo、Yagi Ryotaro、Ogata Seiryo、Masuda Takeshi、Saito Takashi、Saido Takaomi、Ohtsuki Sumio
    • Journal Title

      Fluids and Barriers of the CNS

      Volume: 20 Issue: 1 Pages: 66-66

    • DOI

      10.1186/s12987-023-00466-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14333, KAKENHI-PUBLICLY-22H05546, KAKENHI-PLANNED-23H04937, KAKENHI-PROJECT-21H02649, KAKENHI-PROJECT-23K23867
  • [Journal Article] Technical Basics and Applications of Quantitative Targeted Absolute Proteomics2023

    • Author(s)
      大槻 純男
    • Journal Title

      Proteome Letters

      Volume: 8 Issue: 2 Pages: 35-42

    • DOI

      10.14889/jpros.8.2_35

    • ISSN
      2432-2776
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Journal Article] Advancement of Water Droplet-in-Oil Digestion Method for High-Throughput Single-Cell Proteomics2023

    • Author(s)
      Yamahiro Maki、Masuda Takeshi、Ito Shingo、Ohtsuki Sumio
    • Journal Title

      Journal of the Mass Spectrometry Society of Japan

      Volume: 71 Issue: 4 Pages: 153-154

    • DOI

      10.5702/massspec.S23-52

    • ISSN
      1340-8097, 1880-4225, 1884-3271
    • Year and Date
      2023-12-01
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Journal Article] Data for method development of water droplet-in-oil digestion approach2023

    • Author(s)
      Takeshi Masuda, Norie Araki, Sumio Ohtsuki
    • Journal Title

      Journal of Proteome Data and Methods

      Volume: 5 Pages: 1-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K23867
  • [Journal Article] Development of a method for isolating brain capillaries from a single neonatal mouse brain and comparison of proteomic profiles between neonatal and adult brain capillaries2023

    • Author(s)
      Hamada Yudai、Ogata Seiryo、Masuda Takeshi、Ito Shingo、Ohtsuki Sumio
    • Journal Title

      Fluids and Barriers of the CNS

      Volume: 20 Issue: 1 Pages: 50-50

    • DOI

      10.1186/s12987-023-00449-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14333, KAKENHI-PUBLICLY-22H05546, KAKENHI-PLANNED-23H04937, KAKENHI-PROJECT-21H02649, KAKENHI-PROJECT-23K23867
  • [Journal Article] Human Hepatic Transporter Signature Peptides for Quantitative Targeted Absolute Proteomics: Selection, Digestion Efficiency, and Peptide Stability2022

    • Author(s)
      Mori Ayano、Masuda Takeshi、Ito Shingo、Ohtsuki Sumio
    • Journal Title

      Pharmaceutical Research

      Volume: 39 Issue: 11 Pages: 2965-2978

    • DOI

      10.1007/s11095-022-03387-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Journal Article] Knockdown of Podocalyxin Post-Transcriptionally Induces the Expression and Activity of ABCB1/MDR1 in Human Brain Microvascular Endothelial Cells2022

    • Author(s)
      Nagano Hinako、Ogata Seiryo、Ito Shingo、Masuda Takeshi、Ohtsuki Sumio
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: - Issue: 6 Pages: 1812-1819

    • DOI

      10.1016/j.xphs.2022.02.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-21H02649
  • [Journal Article] Diurnal Changes in Protein Expression at the Blood–Brain Barrier in Mice2022

    • Author(s)
      Ogata Seiryo、Ito Shingo、Masuda Takeshi、Ohtsuki Sumio
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 45 Issue: 6 Pages: 751-756

    • DOI

      10.1248/bpb.b22-00016

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2022-06-01
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Journal Article] Effect of Insulin Receptor-Knockdown on the Expression Levels of Blood?Brain Barrier Functional Proteins in Human Brain Microvascular Endothelial Cells2021

    • Author(s)
      Nagano Hinako、Ito Shingo、Masuda Takeshi、Ohtsuki Sumio
    • Journal Title

      Pharmaceutical Research

      Volume: - Issue: 7 Pages: 1561-1574

    • DOI

      10.1007/s11095-021-03131-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-21H02649
  • [Journal Article] Advances in sample preparation for membrane proteome quantification2021

    • Author(s)
      Masuda Takeshi、Ito Shingo、Ohtsuki Sumio
    • Journal Title

      Drug Discovery Today: Technologies

      Volume: 39 Pages: 23-29

    • DOI

      10.1016/j.ddtec.2021.06.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Journal Article] Quantitative and targeted proteomics-based identification and validation of drug efficacy biomarkers2021

    • Author(s)
      Masuda Takeshi、Mori Ayano、Ito Shingo、Ohtsuki Sumio
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 36 Pages: 100361-100361

    • DOI

      10.1016/j.dmpk.2020.09.006

    • NAID

      210000165083

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-21H02649
  • [Journal Article] Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis2020

    • Author(s)
      Ogata Seiryo、Ito Shingo、Masuda Takeshi、Ohtsuki Sumio
    • Journal Title

      Journal of Cerebral Blood Flow & Metabolism

      Volume: 271678 Issue: 5 Pages: 1026-1038

    • DOI

      10.1177/0271678x20941449

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02590, KAKENHI-PROJECT-19K05544
  • [Journal Article] Novel cyclic peptides facilitating transcellular blood-brain barrier transport of macromolecules in vitro and in vivo2020

    • Author(s)
      1.Shunsuke Yamaguchi, Shingo Ito, Takeshi Masuda, Pierre-Olivier Couraud, Sumio Ohtsuki
    • Journal Title

      J Control Release

      Volume: 321 Pages: 744-755

    • DOI

      10.1016/j.jconrel.2020.03.001

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18J15384, KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-18H02590
  • [Journal Article] Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro2020

    • Author(s)
      Ito Shingo、Oishi Mariko、Ogata Seiryo、Uemura Tatsuki、Couraud Pierre-Olivier、Masuda Takeshi、Ohtsuki Sumio
    • Journal Title

      Pharmaceutics

      Volume: 12 Issue: 6 Pages: 579-579

    • DOI

      10.3390/pharmaceutics12060579

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-18H02590
  • [Journal Article] Knockdown of Orphan Transporter SLC22A18 Impairs Lipid Metabolism and Increases Invasiveness of HepG2 Cells2019

    • Author(s)
      Ito S, Honda G, Fujino Y, Ogata S, Hirayama-Kurogi M, Ohtsuki S
    • Journal Title

      Pharmaceutical research

      Volume: 36 Issue: 3 Pages: 39-39

    • DOI

      10.1007/s11095-018-2565-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08373
  • [Journal Article] Changes of Blood-Brain Barrier and Brain Parenchymal Protein Expression Levels of Mice under Different Insulin-Resistance Conditions Induced by High-Fat Diet.2019

    • Author(s)
      Ogata S, Ito S, Masuda T, Ohtsuki S
    • Journal Title

      Pharm Res

      Volume: 36 Issue: 10 Pages: 141-141

    • DOI

      10.1007/s11095-019-2674-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02590, KAKENHI-PROJECT-19K05544
  • [Journal Article] Large-Scale Quantitative Comparison of Plasma Transmembrane Proteins between Two Human Blood-Brain Barrier Model Cell Lines, hCMEC/D3 and HBMEC/cibeta.2019

    • Author(s)
      Masuda T, Hoshiyama T, Uemura T, Hirayama-Kurogi M, Ogata S, Furukawa A, Couraud PO, Furihata T, Ito S, Ohtsuki S
    • Journal Title

      Mol Pharm

      Volume: 16 Issue: 5 Pages: 2162-2171

    • DOI

      10.1021/acs.molpharmaceut.9b00114

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02590, KAKENHI-PROJECT-19K05544
  • [Journal Article] Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics.2018

    • Author(s)
      Miyauchi E, Furuta T, Ohtsuki S, Tachikawa M, Uchida Y, Sabit H, Obuchi Wm Baba T, Watanabe M, Terasaki T, Nakada M
    • Journal Title

      PLoS One

      Volume: 13 Issue: 3 Pages: e0193799-e0193799

    • DOI

      10.1371/journal.pone.0193799

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K15012, KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-16K15645
  • [Journal Article] Involvement of an Orphan Transporter, SLC22A18, in Cell Growth and Drug Resistance of Human Breast Cancer MCF7 Cells.2018

    • Author(s)
      Ito S, Fujino Y, Ogata S, Hirayama-Kurogi M, Ohtsuki S
    • Journal Title

      Journal of pharmaceutical sciences

      Volume: 107 Issue: 12 Pages: 3163-3170

    • DOI

      10.1016/j.xphs.2018.08.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08373
  • [Journal Article] Identification of cyclic peptides for facilitation of transcellular transport of phages across intestinal epithelium in vitro and in vivo2017

    • Author(s)
      Yamaguchi Shunsuke、Ito Shingo、Kurogi-Hirayama Mio、Ohtsuki Sumio
    • Journal Title

      Journal of Controlled Release

      Volume: 262 Pages: 232-238

    • DOI

      10.1016/j.jconrel.2017.07.037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K15162
  • [Journal Article] Abnormal <i>N</i>-Glycosylation of a Novel Missense Creatine Transporter Mutant, G561R, Associated with Cerebral Creatine Deficiency Syndromes Alters Transporter Activity and Localization2017

    • Author(s)
      T. Uemura, S. Ito, Y. Ohta, M. Tachikawa, T. Wada, T. Terasaki, S. Ohtsuki
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 1 Pages: 49-55

    • DOI

      10.1248/bpb.b16-00582

    • NAID

      130005188881

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26293035, KAKENHI-PROJECT-26461544
  • [Journal Article] Attenuation of Phosphorylation by Deoxycytidine Kinase is Key to Acquired Gemcitabine Resistance in a Pancreatic Cancer Cell Line : Targeted Proteomic and Metabolomic Analyses in PK9 Cells2012

    • Author(s)
      Ohmine K, Kawaguchi K, Ohtsuki S, Motoi F, et al
    • Journal Title

      Pharm Res

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591766
  • [Journal Article] 膵癌の個別化医療分子生物学的解析を中心に2011

    • Author(s)
      元井冬彦, 川口桂, 大峰健, 大槻純男, 大塚英郎, 他
    • Journal Title

      外科

      Volume: 73巻 Pages: 1073-1078

    • Data Source
      KAKENHI-PROJECT-21591766
  • [Journal Article] Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors2011

    • Author(s)
      Y. Uchida, S. Ohtsuki, Y. Katsukura, C. Ikeda, T. Suzuki, J. Kamiie, T. Terasaki
    • Journal Title

      J Neurochem

      Volume: 117(2) Pages: 333-345

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection2011

    • Author(s)
      Hirotaka Kawakami, Sumio Ohtsuki, Junichi Kamiie, Takashi Suzuki, Takaaki Abe, Tetsuya Terasaki
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 100 Pages: 341-352

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22136001
  • [Journal Article] Involvement of multidrug resistance- associated protein 4 in efflux transport of prostaglandin E2 across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins.2010

    • Author(s)
      S. Akanuma, K. Hosoya, S. Ito, M. Tachikawa, T. Terasaki, S. Ohtsuki
    • Journal Title

      J. Pharmacol. Exp. Ther 99

      Pages: 912-919

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Atrial natriuretic peptide is eliminated from the brain by natriuretic peptide receptor-C-mediated brain-to-blood efflux transport at the blood-brain barrier2010

    • Author(s)
      S. Ito, S. Ohtsuki, Y. Katsukura, M. Funaki, Y. Koitabashi, A. Sugino, S. Murata, T. Terasaki
    • Journal Title

      J. Cereb. Blood Flow Metab.

      Volume: 31 Pages: 457-466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Reduction of LAT1 mRNA expression in brain capillaries in a mouse model of Parkinson's disease2010

    • Author(s)
      Ohtsuki S
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 33(7) Pages: 1250-1252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Targeted Absolute Proteomics を用いたトランスポーターの新しい研究展開2009

    • Author(s)
      大槻純男、寺崎哲也
    • Journal Title

      遺伝子医学 12

      Pages: 48-54

    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Targeted Absolute Proteomicsを用いたトランスポーターの新しい研究展開2009

    • Author(s)
      大槻純男
    • Journal Title

      遺伝子医学 12

      Pages: 48-54

    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] 中枢への薬物分布におけるトランスポーターの機能と役割2009

    • Author(s)
      大槻純男、寺崎哲也
    • Journal Title

      日本薬理学雑誌 134

      Pages: 83-86

    • NAID

      10025741265

    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] 中枢への薬物分布におけるトランスポーターの機能と役割2009

    • Author(s)
      大槻純男
    • Journal Title

      日本薬理学雑誌 134

      Pages: 83-86

    • NAID

      10025741265

    • Data Source
      KAKENHI-PROJECT-19390038
  • [Journal Article] 中枢への薬物分布におけるトランスポーターの機能と役割2009

    • Author(s)
      大槻純男
    • Journal Title

      日本薬理学雑誌 134

      Pages: 83-86

    • NAID

      10025741265

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] 中枢への薬物分布におけるトランスポーターの機能と役割2009

    • Author(s)
      大槻純男
    • Journal Title

      日本薬理学雑誌

      Volume: 134 Pages: 83-86

    • NAID

      10025741265

    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Targeted Absolute Proteomicsを用いたトランスポーターの新しい研究展開2009

    • Author(s)
      大槻純男、上家潤一、寺崎哲也
    • Journal Title

      遺伝子医学MOOK12

      Pages: 48-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] 中枢への薬物分布におけるトランスポーターの機能と役割2009

    • Author(s)
      大槻純男
    • Journal Title

      日本薬理学雑誌 134

      Pages: 83-86

    • NAID

      10025741265

    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Targeted Absolute Proteomicsを用いたトランスポーターの新しい研究展開2009

    • Author(s)
      大槻純男、上家潤一、寺崎哲也
    • Journal Title

      遺伝子医学MOOK12

      Pages: 48-54

    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Quantitative atlas of membrane transporter proteins: Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria.2008

    • Author(s)
      Kamiie J, Ohtsuki S, Iwase R, Ohmine K, Katsukura Y, Yanai K, Sekine Y, Uchida Y, Ito S, Terasaki T
    • Journal Title

      Pharm. Res 25

      Pages: 1469-1483

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] 血液脳関門におけるモノアミン関連トランスポーターの役割2008

    • Author(s)
      大槻純男
    • Journal Title

      Clinical Neuroscience 26

      Pages: 1077-1080

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting.2008

    • Author(s)
      Ohtsuki S, Yamaguchi H, Katsukura Y, Asashima T, Terasaki T
    • Journal Title

      J. Neurochem 104

      Pages: 147-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Quantitative atlas of membrane transporter proteins : Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria2008

    • Author(s)
      J. Kamiie, S. Ohtsuki, R. Iwase, K. Ohmine, Y. Katsukura, K. Yanai, Y. Sekine, Y. Uchida, S. Ito, T. Terasaki
    • Journal Title

      Pharm. Res. 25

      Pages: 1469-1483

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting2008

    • Author(s)
      S. Ohtsuki, H. Yamaguchi, Y. Katsukura, T. Asashima, T. Terasaki
    • Journal Title

      J. Neurochem.

      Volume: 104 Pages: 147-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting2008

    • Author(s)
      S. Ohtsuki
    • Journal Title

      J. Neurochem 104

      Pages: 147-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] 生体膜分子を基盤とする薬剤開発・治療に向けた新展開2008

    • Author(s)
      大槻純男, 崔吉道
    • Journal Title

      薬学雑誌 128

      Pages: 495-496

    • NAID

      110006656187

    • Data Source
      KAKENHI-PROJECT-19390038
  • [Journal Article] Quantitative atlas of membrane transporter proteins : Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria2008

    • Author(s)
      J. Kamiie, S. Ohtsuki, R. Iwase, K. Ohmine, Y. Katsukura, K. Yanai, Y. Sekine, Y. Uchida, S. Ito, T. Terasaki
    • Journal Title

      Pharm.Res. 25

      Pages: 1469-1483

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Journal Article] mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting2008

    • Author(s)
      S. Ohtsuki, H. Yamaguchi, Y. Katsukura, T. Asashima, T. Terasaki
    • Journal Title

      J. Neurochem 104

      Pages: 147-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting.2008

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      Journal of Neurochemistry 104

      Pages: 147-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Journal Article] Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier.2008

    • Author(s)
      Akanuma S, Hori S, Ohtsuki S, Fujiyoshi M, Terasaki T
    • Journal Title

      Neurochem. Int 52

      Pages: 669-674

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] 生体膜分子を基盤とする薬剤開発・治療に向けた新展開2008

    • Author(s)
      大槻純男
    • Journal Title

      薬学雑誌 128

      Pages: 495-496

    • NAID

      110006656187

    • Data Source
      KAKENHI-PROJECT-19390038
  • [Journal Article] mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting.2008

    • Author(s)
      S. Ohtsuki
    • Journal Title

      J. Neurochem. 104

      Pages: 147-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Quantitative atlas of membrane transporter proteins : Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria2008

    • Author(s)
      J. Kamiie, S. Ohtsuki, R. Iwase, K. Ohmine, Y. Katsukura, K. Yanai, Y. Sekine, Y. Uchida, S. Ito, T. Terasaki
    • Journal Title

      Pharm. Res.

      Volume: 25 Pages: 1469-1483

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting.2008

    • Author(s)
      S. Ohtsuki
    • Journal Title

      J. Neurochem 104

      Pages: 147-154

    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting2008

    • Author(s)
      S. Ohtsuki, H. Yamaguchi, Y. Katsukura, T. Asashima, T. Terasaki
    • Journal Title

      J.Neurochem. 104

      Pages: 147-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Journal Article] Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier2008

    • Author(s)
      S. Akanuma, S. Hori, S. Ohtsuki, M. Fujiyoshi, T. Terasaki
    • Journal Title

      Neurochem. Int.

      Volume: 52 Pages: 669-674

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Multichannel liquid chromatography. tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter2007

    • Author(s)
      Y. Uchida, J. Kamiie, S. Ohtsuki, T. Terasaki
    • Journal Title

      Pharm. Res.

      Volume: 24 Pages: 2281-2296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discoverv and development.2007

    • Author(s)
      S. Ohtsuki
    • Journal Title

      Pharm. Res. 24

      Pages: 1745-1757

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor.2007

    • Author(s)
      Ohtsuki S, Kamoi M, Watanabe Y, Suzuki H, Hori S, Terasaki T
    • Journal Title

      Biol. Pharm. Bull 30

      Pages: 1144-1146

    • NAID

      110006278407

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter2007

    • Author(s)
      Y. Uchida, J. Kamiie, S. Ohtsuki, T. Terasaki
    • Journal Title

      Pharm.Res. 24

      Pages: 2281-2296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Journal Article] Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells2007

    • Author(s)
      . S. Ohtsuki, H. Yamaguchi, T. Asashima, T. Terasaki
    • Journal Title

      Pharm. Res. 24

      Pages: 588-694

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain2007

    • Author(s)
      S. Ohtsuki, T. Terasaki
    • Journal Title

      Pharm. Res.

      Volume: 24 Pages: 1745-1758

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier2007

    • Author(s)
      S. Ohtsuki, S. Ito, A. Matsuda, S. Hori, T. Abe, T. Terasaki
    • Journal Title

      J.Neurochem. 103

      Pages: 1430-1438

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Journal Article] Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development.2007

    • Author(s)
      S. Ohtsuki
    • Journal Title

      Pharm. Res. 24

      Pages: 1745-1757

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Brain-to-blood elimination of 24S-hydroxy- cholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier.2007

    • Author(s)
      Ohtsuki S, Ito S, Matsuda A, Hori S, Abe T, Terasaki T
    • Journal Title

      J. Neurochem 103

      Pages: 1430-1438

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier.2007

    • Author(s)
      S. Ohtsuki
    • Journal Title

      J. Neurochem. 103

      Pages: 1430-1438

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Multichannel Liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter.2007

    • Author(s)
      Uchida Y, Kamiie J, Ohtsuki S, Terasaki T
    • Journal Title

      Pharm. Res 24

      Pages: 2281-2296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells.2007

    • Author(s)
      S. Ohtsuki
    • Journal Title

      Pharm. Res. 24

      Pages: 688-694

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2(oatp2)at the blood-brain barrier2007

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      Journal of Neurochemistry 103

      Pages: 2482-2490

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Journal Article] Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor.2007

    • Author(s)
      S. Ohtsuki
    • Journal Title

      Biol. Pharm. Bull. 30

      Pages: 1144-1146

    • NAID

      110006278407

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells2007

    • Author(s)
      S. Ohtsuki, H. Yamaguchi, T. Asashima, T. Terasaki
    • Journal Title

      Pharm. Res.

      Volume: 24 Pages: 588-694

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells.2007

    • Author(s)
      Ohtsuki S, Yamaguchi H, Asashima T, Terasaki T
    • Journal Title

      Pharm. Res 24

      Pages: 688-694

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] 24S-Hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression.2007

    • Author(s)
      Fujiyoshi M, Ohtsuki S, Hori S, Tachikawa M, Terasaki T
    • Journal Title

      J. Neurochem 100

      Pages: 968-978

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain ; importance for CNS drug discovery and development2007

    • Author(s)
      S. Ohtsuki, T. Terasaki
    • Journal Title

      Pharm. Res. 24

      Pages: 1745-1758

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells.2007

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Pharm. Res. 24

      Pages: 588-694

    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro.2007

    • Author(s)
      M. Belanger, T. Asashima, S. Ohtsuki, H. Yamaguchi, S. Ito, T. Terasaki
    • Journal Title

      Neurochem. Int 50

      Pages: 95-101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter2007

    • Author(s)
      Y. Uchida, J. Kamiie, S. Ohtsuki, T. Terasaki
    • Journal Title

      Pharm. Res. 24

      Pages: 2281-2296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Journal Article] ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells.2006

    • Author(s)
      Asashima T, Hori S, Ohtsuki S, Tachikawa M, Watanabe M, Mukai C, Kitagaki S, Miyakoshi N, Terasaki T
    • Journal Title

      Pharm Res 23

      Pages: 1235-1242

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] 脳関門輸送の分子機構と脳へのDDS2006

    • Author(s)
      大槻 純男
    • Journal Title

      DDS学会誌 21

      Pages: 102-110

    • NAID

      10018118754

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice.2006

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Biol. Pharm. Bull. 29

      Pages: 1587-1591

    • NAID

      110005663994

    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Molecular mechanisms of the blood-brain barrier transport and DDS to the brain.2006

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      Drug Delivery System 21

      Pages: 102-110

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Major involvement of low-density lipoprotein receptor- related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver.2006

    • Author(s)
      Tamaki C., Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T
    • Journal Title

      Pharm Res 23

      Pages: 1407-1416

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice.2006

    • Author(s)
      Ohtsuki S, Kikkawa T, Hori S, Terasaki T
    • Journal Title

      Biol. Pharm. Bull 29

      Pages: 1587-1591

    • NAID

      110005663994

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] 脳関門輸送の分子機構と脳へのDDS2006

    • Author(s)
      大槻純男
    • Journal Title

      DDS学会誌 21

      Pages: 102-110

    • NAID

      10018118754

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Dominant expression of androgen receptors and their functional regulation of organic anion transporter 3 in rat brain capillary endothelial cells; comparison of gene expression between the blood-brain and -retinal barriers.2005

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      Journal of Cellular Physiology 204

      Pages: 896-900

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Vascular endothelium-selective gene induction by Tie2 promoter/enhancer in the brain and retina of a transgenic rat.2005

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Pharm. Res. 22

      Pages: 852-857

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] 脳を守る血液脳関門の輸送機構2005

    • Author(s)
      大槻 純男
    • Journal Title

      CYRICニュース 37

      Pages: 4-11

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Vascular endothelium-selective gene induction by Tie2 promoter/enhancer in the brain and retina of a transgenic rat.2005

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Pharm.Res. 22

      Pages: 852-857

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Dominant expression of androgen receptors and their functional regulation of organic anion transporter 3 in rat brain capill ary endothelial cells ; comparison of gene expression between the blood-brain and-retinal barriers.2005

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      J.Cell.Physiol. 204

      Pages: 896-900

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Dominant expression of androgen receptors and their functional regulation of organic anion transporter 3 in rat brain capillary endothelial cells; comparison of gene expression between the blood-brain and -retinal barriers.2005

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J. Cell. Physiol. 204

      Pages: 896-900

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Dominant expression of androgen receptors and their functional regulation of organic anion transporter 3 in rat brain capillary endothelial cells ; comparison of gene expression between the blood-brain and -retinal barriers.2005

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J.Cell.Physiol. 204

      Pages: 896-900

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain.2005

    • Author(s)
      Tachikawa M, Watanabe M, Hori S, Fukaya M, Ohtsuki S, Asashima T, Terasaki T
    • Journal Title

      J Neurochem 95

      Pages: 294-304

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Journal Article] Dominant expression of androgen receptors and their functional regulation of organic anion transporter 3 in rat brain capillary endothelial cells ; comparison of gene expression between the blood-brain and -retinal barriers.2005

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      J.Cell.Physiol. 204

      Pages: 896-900

    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Transport system at the blood-brain barrier to protect brain functions.2005

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      CYRIC News 37

      Pages: 4-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells.2004

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      Biol.Pharm.Bull. 27

      Pages: 1437-1440

    • NAID

      110003608990

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Localization of organic anion transporting polypepetide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells.2004

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J. Neurochem. 90

      Pages: 743-749

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] New aspects of the blood brain barrier transporters; its physiological roles in the central nervous system.2004

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      Biological & Pharmaceutical Bulletin 27

      Pages: 1489-1496

    • NAID

      110003608642

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Mouse "reduced in osteosclerosis" transporter (Roct) functions as an organic anion transporter 3 (mOAT3) and is localized at abluminal membrane of blood-brain barrier.2004

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J. Pharmacol. Exp. Ther. 309

      Pages: 1273-1281

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells.2004

    • Author(s)
      S.Ohtsuki et al.
    • Journal Title

      Journal of Neurochemistry 90

      Pages: 743-749

    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Physiological roles of the blood-brain barrier transport system as CN S supporting and protecting system.2004

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      Yakugaku Zasshi 24

      Pages: 791-802

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Localization of organic anion transporting polypepetide 3(oatp3) in mouse brain parenchymal and capillary endothelial cells.2004

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J.Neurochem. 90

      Pages: 743-749

    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells.2004

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      J.Neurochem. 90

      Pages: 743-749

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] 中枢支援防御システムとしての血液脳関門輸送の生理機能2004

    • Author(s)
      大槻純男
    • Journal Title

      薬学雑誌 24

      Pages: 791-802

    • NAID

      110003666135

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells.2004

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      Journal of Neurochemistry 90

      Pages: 743-749

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] New aspects of the blood brain barrier transporters ; its physiological roles in the central nervous system.2004

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Biological & Pharmaceutical Bulletin 27

      Pages: 1489-1496

    • NAID

      110003608642

    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] New aspects of the blood brain barrier transporters; its physiological roles in the central nervous system.2004

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      Biol.Pharm.Bull. 27

      Pages: 1489-1496

    • NAID

      110003608642

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells.2004

    • Author(s)
      S.Ohtsuki et al.
    • Journal Title

      Biological & Pharmaceutical Bulletin 27

      Pages: 1437-1440

    • NAID

      110003608990

    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells.2004

    • Author(s)
      Sumio Ohtsuki
    • Journal Title

      Biological & Pharmaceutical Bulletin 27

      Pages: 1437-1440

    • NAID

      110003608990

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390037
  • [Journal Article] Localization of organic anion transporting polypepetide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells.2004

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J.Neurochem. 90

      Pages: 743-749

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Mouse "reduced in osteosclerosis" transporter (Roct) functions as an organic anion transporter 3 (mOAT3) and is localized at abluminal membrane of blood-brain barrier.2004

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J.Pharmacol.Exp.Ther. 309

      Pages: 1273-1281

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells.2004

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Biol.Pharm.Bull. 27

      Pages: 1437-1440

    • NAID

      110003608990

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] ダイナミック輸送システムとしての血液脳関門と中枢創薬研究への応用2004

    • Author(s)
      大槻純男
    • Journal Title

      月刊薬事 46

      Pages: 1243-1249

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Application of the blood brain barrier transport as a dynamic transport system.2004

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Monthly Yakuji 46

      Pages: 1243-1249

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Mouse "reduced in osteosclerosis" transporter (Roct) functions as an organic anion transporter 3(mOAT3) and is localized at abluminal membrane of blood-brain barrier.2004

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J.Pharmacol.Exp.Ther. 309

      Pages: 1273-1281

    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells.2004

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Biol. Pharm. Bull. 27

      Pages: 1437-1440

    • NAID

      110003608990

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] mRNA expression of the ATP-binding cassette transporter subfamily A(ABCA) in rat and human brain capillary endothelial cells.2004

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Biol.Pharm.Bull. 27

      Pages: 1437-1440

    • NAID

      110003608990

    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] In vitro study on the functional expression of organic anion transporting polypeptide 3 at rat choloid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood-transport of estrone-3-sulfate.2003

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Mol.Pharmacol. 63

      Pages: 532-537

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Serotonin transporter at the blood-brain barrier.2003

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Clinical neuroscience 21(6)

      Pages: 641-643

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] 血液脳関門の薬物透過と排出の分子機構 〜中枢支援防御システム〜2003

    • Author(s)
      大槻純男
    • Journal Title

      日本薬理学雑誌 122

      Pages: 55-64

    • NAID

      130000085998

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Molecular physiology of the blood-brain barrier.2003

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Farumashia 39

      Pages: 1057-1061

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] 脳を守る脳関門トランスポーター2003

    • Author(s)
      大槻純男
    • Journal Title

      未来材料(Review視点-護る) 3

      Pages: 2-6

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] 血液脳関門の分子生理2003

    • Author(s)
      大槻純男
    • Journal Title

      ファルマシア 39

      Pages: 1057-1061

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] 血液脳関門におけるセロトニントランスポーター2003

    • Author(s)
      大槻純男
    • Journal Title

      Clinical Neuroscience 21(6)

      Pages: 641-643

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] The blood-brain barrier protecting the brain.2003

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Future materials 3

      Pages: 2-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Molecular mechanism in the drug permeation and efflux at the blood-brain barrier.2003

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Folia Pharmacoligica Japonica 122

      Pages: 55-64

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] In vitro study on the functional expression of organic anion transporting polypeptide 3 at rat choloid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood-transport of estrone-3-sulfate.2003

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Mol. Pharmacol. 63

      Pages: 532-537

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Physiological roles of the blood-brain barrier transport as the CNS supporting and protecting system.2002

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Basics and clinics in neuroscience Vol 11

      Pages: 23-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain.2002

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J.Cereb.Blood Flow Metab. 22

      Pages: 1327-1335

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Role of blood-brain barrier organic anion transporter 3 (OATS) in the efflux of indoxyl sulfate, a uremic toxin : Its involvement in neurotransmitter metabolite clearance from the brain.2002

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J.Neurochem. 83

      Pages: 57-66

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain.2002

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J. Cereb. Blood Flow Metab. 22

      Pages: 1327-1335

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Journal Article] Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin : Its involvement in neurotransmitter metabolite clearance from the brain.2002

    • Author(s)
      S.Ohtsuki
    • Journal Title

      J. Neurochem. 83

      Pages: 57-66

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207104
  • [Patent] 悪性グリオーマ再発マーカー及びその使用2023

    • Inventor(s)
      中田光俊、大槻純男
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-048855
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-22H00484
  • [Patent] 血液脳関門透過性ペプチド2019

    • Inventor(s)
      19.伊藤慎悟、大槻純男、山口駿介
    • Industrial Property Rights Holder
      19.伊藤慎悟、大槻純男、山口駿介
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Patent] 血液脳関門透過性ペプチド2018

    • Inventor(s)
      伊藤慎悟、大槻純男、山口駿介
    • Industrial Property Rights Holder
      伊藤慎悟、大槻純男、山口駿介
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-134042
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Patent] 膠芽腫マーカー及びその使用2017

    • Inventor(s)
      中田光俊,寺崎哲也、大槻純男
    • Industrial Property Rights Holder
      中田光俊,寺崎哲也、大槻純男
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-233838
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-16K15645
  • [Patent] 新規な細胞膜透過性ペプチド2017

    • Inventor(s)
      伊藤慎悟、大槻純男
    • Industrial Property Rights Holder
      伊藤慎悟、大槻純男
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16K15162
  • [Patent] 新規な細胞膜透過性ペプチド2016

    • Inventor(s)
      伊藤慎悟、大槻純男
    • Industrial Property Rights Holder
      熊本大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-05-18
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16K15162
  • [Patent] 質量分析におけるペプチドピークの同定・定量のためのデータベース作成方法2014

    • Inventor(s)
      大槻純男
    • Industrial Property Rights Holder
      大槻純男
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-07-07
    • Overseas
    • Data Source
      KAKENHI-PROJECT-26640092
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2011

    • Inventor(s)
      上家潤一、大槻純男、寺崎哲也
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Filing Date
      2011-03-08
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2011

    • Inventor(s)
      上家潤一、大槻純男、寺崎哲也
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Filing Date
      2011-01-28
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2010

    • Inventor(s)
      上家潤一、大槻純男、寺崎哲也
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Filing Date
      2010-10-07
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤三大槻純男寺崎哲也
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-05-08
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤一、大槻純男、寺崎哲也
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Filing Date
      2008-05-08
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤一大槻純男寺崎哲也
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-05-06
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤一、大槻純男、寺崎哲也
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Filing Date
      2008-05-22
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤一、大槻純男、寺崎哲也
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Filing Date
      2008-05-16
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤一、大槻純男、寺崎哲也
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Filing Date
      2008-05-08
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤一大槻純男寺崎哲也
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-05-22
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤三大槻純男寺崎哲也
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-05-16
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤一、大槻純男、寺崎哲也
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Filing Date
      2008-06-17
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤一大槻純男寺崎哲也
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-05-08
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤一大槻純男寺崎哲也
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-06-17
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Patent] 質量分析計を使った膜タンパク質の定量方法2008

    • Inventor(s)
      上家潤一、大槻純男、寺崎哲也
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Filing Date
      2008-05-06
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] 1細胞プロテオミクス技術の 開発と応用2023

    • Author(s)
      増田豪, 山廣万喜, 伊藤慎悟, 大槻純男
    • Organizer
      第71回 質量分析討論会
    • Data Source
      KAKENHI-PROJECT-23K23867
  • [Presentation] ハイスループット1細胞プロテオミクスシステムの構築2023

    • Author(s)
      増田豪, 山廣万貴, 伊藤慎悟, 大槻純男
    • Organizer
      日本プロテオーム学会2023年大会
    • Data Source
      KAKENHI-PROJECT-23K23867
  • [Presentation] Proteome-based approach to human health and disease2023

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      CCII/ CGM Joint Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] Analysis of the differences in brain microvascular endothelial cells between mice and humans by deep proteomics2023

    • Author(s)
      Haruka Kumabe, Takeshi Masuda, Tomomi Furihata, Shingo Ito, Norie Araki, Sumio Ohtsuki
    • Organizer
      Cerebral Vascular Biology 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-23H04937
  • [Presentation] 定量プロテオミクスを利用した新生児マウス単離脳毛細血管の評価と血液脳関門プロテオームの成長変化の解明2023

    • Author(s)
      濱田祐大、緒方星陵、増田豪、伊藤慎悟、大槻純男
    • Organizer
      日本プロテオーム学会2023年大会
    • Data Source
      KAKENHI-PLANNED-23H04937
  • [Presentation] Efficient isolation of brain capillary from a single frozen mouse brain and a small amount of frozen human brain for protein expression analysis.2023

    • Author(s)
      Shingo Ito, Serio Ogata, Takeshi Masuda, Sumio Ohtsuki
    • Organizer
      Cerebral Vascular Biology 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] 最新プロテオームを活用した細胞機能の解析2023

    • Author(s)
      大槻純男
    • Organizer
      第3回NCBAワーキンググループ研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] 高深度プロテオミクスを用いた血液脳関門の種差の解明2023

    • Author(s)
      隈部遥香、増田豪、降幡知巳、伊藤慎悟、荒木令江、大槻純男
    • Organizer
      日本プロテオーム学会2023年大会
    • Data Source
      KAKENHI-PLANNED-23H04937
  • [Presentation] 最新プロテオームを活用した細胞機能の解析2023

    • Author(s)
      大槻純男
    • Organizer
      第3回NCBAワーキンググループ研究会
    • Invited
    • Data Source
      KAKENHI-PLANNED-23H04937
  • [Presentation] Methodologies and applications of proteomics for biomarker research2023

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      2023 ICCP450/JSSX
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-23H04937
  • [Presentation] プロテオーム解析に基づく脳内Aβ蓄積による脳病態進行と血液脳関門障害の関係の解明2023

    • Author(s)
      伊藤慎悟, 八木遼太郎, 緒方星陵, 増田豪, 斉藤貴志, 西道隆臣, 大槻純男
    • Organizer
      第42回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] オミクスでトランスレーションの「壁」を壊せるのか?2023

    • Author(s)
      大槻純男
    • Organizer
      第27回 薬物動態談話会セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] Blood-Brain Barrier Proteomics2023

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      5th Mini-Symposium on the Blood-Brain Barrier
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] Ataxin-2 as a biomarker candidate for distinguishing pseudoprogression from recurrence in glioblastoma2023

    • Author(s)
      Garaeva F, Sabit H, Nakajima R, Ichinose T, Tamai S, Kinoshita M, Ohtsuki S, Nakada M, BIRD-DOG team
    • Organizer
      第23回日本分子脳神経外科学会
    • Data Source
      KAKENHI-PROJECT-22H00484
  • [Presentation] High-throughput single-cell proteomics based on water droplet-in-oil digestion method2023

    • Author(s)
      Takeshi MASUDA, Maki YAMAHIRO, Shingo ITO, Sumio OHTSUKI
    • Organizer
      HUPO 2023 World Congress
    • Data Source
      KAKENHI-PROJECT-23K23867
  • [Presentation] 膠芽腫病勢診断血液バイオマーカーAtaxin-2の検証2023

    • Author(s)
      中田光俊、大槻純男、内田康雄、中嶋理帆、武笠晃丈、松﨑 啓亮、篠山隆司、長嶋宏明、川端信司、矢木亮吉、立石健祐、長尾景充、齋藤紀彦、棗田学、田中將太、花谷亮典、廣瀬雄一、荒川芳輝、近藤聡英、石川栄一、吉本幸司、阿部竜也、黒住和彦、木下雅史、BIRD-DOG team
    • Organizer
      第41回日本脳腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-22H00484
  • [Presentation] Narrow isolation windowsによるSWATH-DIAによるタンパク質同定数の向上2023

    • Author(s)
      孔新、 山本 拓実、 隈部 遥香、 田代 尚人、 増田 豪、 伊藤 慎悟、 大槻 純男
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PLANNED-23H04937
  • [Presentation] マウス凍結脳からの脳毛細血管単離法の開発とBBBプロテオーム変動解析への応用2023

    • Author(s)
      伊藤慎悟, 緒方星陵, 八木遼太郎, 増田豪, 大槻純男
    • Organizer
      日本薬剤学会第38年会
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] クレアチントランスポーター欠損マウスを用いた経口投与後のクレアチン体内動態の解明2023

    • Author(s)
      田代 尚人、宮野 綾華、伊藤 慎悟、杉本 道彦、荒木 喜美、中尾 聡宏、中潟 直己、竹尾 透、増田 豪、大槻 純男
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] 高深度プロテオミクスを用いた血液脳関門の種差の解明2023

    • Author(s)
      隈部遥香、増田豪、降幡知巳、伊藤慎悟、荒木令江、大槻純男
    • Organizer
      日本プロテオーム学会2023年大会
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] 定量プロテオミクスを利用した新生児マウス単離脳毛細血管の評価と血液脳関門プロテオームの成長変化の解明2023

    • Author(s)
      濱田 祐大, 緒方星陵, 増田豪, 伊藤 慎悟, 大槻 純男
    • Organizer
      日本プロテオーム学会2023年大会
    • Data Source
      KAKENHI-PROJECT-23K23867
  • [Presentation] 高深度プロテオミクスを用いた血液脳関門の種差の解明2023

    • Author(s)
      隈部 遥香, 増田豪, 降幡 知巳, 伊藤 慎悟, 荒木 令江, 大槻 純男
    • Organizer
      日本プロテオーム学会2023年大会
    • Data Source
      KAKENHI-PROJECT-23K23867
  • [Presentation] 1細胞プロテオミクスのハイスループット化に向けた油中液滴法の改良2023

    • Author(s)
      山廣万喜, 増田豪, 伊藤慎悟, 大槻純男
    • Organizer
      第71回 質量分析討論会
    • Data Source
      KAKENHI-PROJECT-23K23867
  • [Presentation] Analysis of the differences in brain microvascular endothelial cells between mice and humans by deep proteomics.2023

    • Author(s)
      Haruka Kumabe, Takeshi Masuda, Tomomi Furihata, Shingo Ito, Norie Araki, Sumio Ohtsuki
    • Organizer
      Cerebral Vascular Biology 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] 1細胞プロテオミクスのハイスループット化に向けた油中駅適法の改良2023

    • Author(s)
      山廣万貴、増田豪、伊藤慎悟、大槻純男
    • Organizer
      第71回質量分析総合討論
    • Data Source
      KAKENHI-PLANNED-23H04937
  • [Presentation] 定量プロテオミクスを利用した新生児マウス単離脳毛細血管の評価と血液脳関門プロテオームの成長変化の解明2023

    • Author(s)
      濱田祐大、緒方星陵、増田豪、伊藤慎悟、大槻純男
    • Organizer
      日本プロテオーム学会2023年大会
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] Cyclic peptide carriers to facilitate intestinal absorption and BBB permeability2023

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      BI Nanocarrier Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] 組織関門透過環状ペプチドを用いたバイオ医薬品送達技術の開発2023

    • Author(s)
      大槻純男
    • Organizer
      第44回 生体膜と薬物の相互作用シンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-23H04937
  • [Presentation] Isolation of brain capillaries from a single frozen mouse brain for quantitative proteomics2023

    • Author(s)
      Shingo Ito, Serio Ogata, Takeshi Masuda, Sumio Ohtsuki
    • Organizer
      AFPS2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] Regulation of the blood-brain barrier by membrane receptor2022

    • Author(s)
      Sumio Ohtsuki, Hinako Nagano, Seiryo Ogata, Takeshi Masuda, Shingo Ito
    • Organizer
      4th Mini-Symposium on the Blood-Brain Barrier from Basic to Clinical Research
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] 多施設共同研究による膠芽腫病勢診断血液バイオマーカーの同定2022

    • Author(s)
      中田光俊、大槻純男、内田康雄、中嶋理帆、篠山隆司、長嶋宏明、立石健祐、齋藤紀彦、平井希、棗田学、塚本佳広、吉本幸司、花谷亮典、比嘉那優大、近藤聡英、石川栄一、武笠晃丈、廣瀬雄一、荒川芳輝、黒住和彦、阿部竜也、川端信司、田中將太、木下雅史、BIRD-DOG team
    • Organizer
      第39回日本脳腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-22H00484
  • [Presentation] Changes in creatine levels in mouse models of creatine transporter deficiency syndrome2022

    • Author(s)
      Ayaka Miyano, Shingo Ito, Yumi Iwata, Shin Nishiumi, Tomohide Gotoh, Michihiko Sugimoto, Kimi Araki, Satohiro Nakao, Naomi Nakagata, Toru Takeo, Takeshi Masuda, Sumio Ohtsuki
    • Organizer
      The 3rd international virtual forum on modern pharmacology and toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] Receptor-mediated transport for delivery of macro- and middle-molecular drug across biological barriers.2022

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      日本薬物動態学会第37回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] 膠芽腫病勢診断バイオマーカー同定の試み2022

    • Author(s)
      中田光俊、大槻純男、内田康雄、中嶋理帆、木下雅史、BIRD-DOG team
    • Organizer
      第40回日本脳腫瘍病理学会
    • Data Source
      KAKENHI-PROJECT-22H00484
  • [Presentation] Identification of blood biomarkers for differentiating pseudoprogression from recurrence in glioblastoma2022

    • Author(s)
      Nakada M, Ohtsuki S, Uchida Y, Nakajima R, Sabit H, Tamai S, Ichinose T, Kinoshita M, BIRD-DOG team
    • Organizer
      Society for Neuro-Oncology 27th Annual Meeting 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H00484
  • [Presentation] Cyclic peptides facilitating intestinal absorption and blood-brain barrier permeability2021

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      Pacifichem2021
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] エチレングリコールを用いた細胞分画法とプロテオミクスへの応用2021

    • Author(s)
      増田豪、伊藤慎悟、石濱泰、大槻純男
    • Organizer
      第42回生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] 脂溶性カテキン誘導体と相互作用するタンパク質の同定2021

    • Author(s)
      池水文香、藤本康平、増田豪、平山未央、大槻純男、八田大典、城谷圭朗、田中隆、岩田修永
    • Organizer
      日本生化学会九州支部例会
    • Data Source
      KAKENHI-PROJECT-18K06787
  • [Presentation] 細胞膜タンパク質ビオチン標識法とSWATH-MSによる網羅的タンパク質定量法を組み合わせたヒト脳毛細血管内皮細胞における細胞内内在化膜タンパク質の同定2021

    • Author(s)
      伊藤慎悟、大石真梨子、緖方星陵、上村立記、Pierre-Olivier Couraud、増田豪、大槻純男
    • Organizer
      第37回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] マウス大脳と小脳の単離毛細血管における血液脳関門プロテオーム比較解析2021

    • Author(s)
      吉田尚功、伊藤慎悟、緒方星陵、増田豪、大槻純男
    • Organizer
      日本薬剤学会第36年会
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] Impact of intestinal flora on host metabolism of drug, sugar and lipid2021

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      The 39th Frontier Scientists Workshop
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] 質量分析を用いた高感度タンパク質定量のノウハウ2021

    • Author(s)
      大槻純男
    • Organizer
      慶應薬学先端実学(サイヤンス)セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02649
  • [Presentation] オミクスの網羅的・定量的解析によって拓かれる創薬・動態研究2019

    • Author(s)
      大槻純男
    • Organizer
      薬物動態談話会 1月例会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] ミクログリアの細胞表面に発現するアルツハイマー病危険因子CD33のリガンドの同定2019

    • Author(s)
      太田千晴、於久祐己、堀祐真、長井京介、増田豪、大槻純男、長田重一、城谷圭朗、岩田修永
    • Organizer
      第36回日本薬学会九州支部大会
    • Data Source
      KAKENHI-PROJECT-18K06787
  • [Presentation] Identification of cyclic peptide facilitating permeability of M13 phage across the blood-brain barrier,2019

    • Author(s)
      Shunsuke Yamaguchi, Shingo Ito, Takeshi Masuda, Sumio Ohtsuki
    • Organizer
      2019 Cerebral Vascular Biology Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] Identification of cell-surface proteins internalized into in vitro human brain microvascular endothelial cells by SWATH-based quantitative proteomics.2019

    • Author(s)
      Shingo Ito, Mariko Oishi, Tatsuki Uemura, Takeshi Masuda, Tomomi Furihata, Pierre-Olivier Couraud, Sumio Ohtsuki
    • Organizer
      BBB signaling 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] Cyclic peptides facilitating BBB permeability of macromolecules.2019

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      1st Mini-Symposium on the Blood Brain Barrier
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] 高分子を脳実質へ送達する血液脳関門透過性環状ペプチドの同定2019

    • Author(s)
      山口駿介、伊藤慎悟、増田豪、大槻純男
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] Identification of internalized plasma membrane proteins in human brain capillary endothelial cells.2018

    • Author(s)
      Mariko Oishi, Shingo Ito, Takeshi Masuda, Tomomi Furihata, Sumio Ohtsuki
    • Organizer
      Mass Spec and Proteomics 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] Comprehensive identification of internalized membrane proteins in human brain capillary endothelial cells.2018

    • Author(s)
      Mariko Oishi, Shingo Ito, Takeshi Masuda, Tomomi Furihata, Sumio Ohtsuki
    • Organizer
      The 2nd Workshop for Korea-Japan Young Scientists on Pharmaceutics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] 環状ペプチドによる小腸透過キャリアの開発2018

    • Author(s)
      大槻純男、増田豪、伊藤慎悟
    • Organizer
      立命館大学創剤研究コンソーシアム2017年度第2回研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15162
  • [Presentation] 脳内への高分子送達に資する新規BBB透過性環状ペプチドの同定2018

    • Author(s)
      山口駿介、伊藤慎悟、増田豪、大槻純男
    • Organizer
      第12回次世代を担う若手医療薬科学シンポジウム
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] Membrane enrichment for targeted proteomics of enzymes and transporters in different tissues and cell lines.2018

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      ISSX Workshop on LC-MS Proteomics
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] Identification of novel internalized cell surface proteins in human brain capillary endothelial cells by SWATH-MS2018

    • Author(s)
      Shingo Ito, Mariko Oishi, Takeshi Masuda, Tomomi Furihata, Sumio Ohtsuki
    • Organizer
      SFN2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] インスリン抵抗性マウスにおける脳関門および脳実質のタンパク質発現および機能変動の解明2018

    • Author(s)
      緒方星陵、伊藤慎悟、増田豪、大槻純男
    • Organizer
      創剤フォーラム第24回若手研究会
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] 定量プロテオミクスを活用した脳血管研究2018

    • Author(s)
      大槻純男
    • Organizer
      第2回九州血管の会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] 高分子医薬品の脳内送達に資する血液脳関門透過性環状ペプチドの同定2018

    • Author(s)
      山口駿介、伊藤慎悟、増田豪、大槻純男
    • Organizer
      第1回超分子薬剤学FGシンポジウム
    • Data Source
      KAKENHI-PROJECT-18H02590
  • [Presentation] 経口投与型高分子医薬品の開発を目指した小腸透過性環状ペプチドの同定と評価2017

    • Author(s)
      原田智徳、山口駿介、増田豪、伊藤慎悟、大槻純男
    • Organizer
      第41回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K15162
  • [Presentation] 患者由来iPS細胞を利用したアルツハイマー病のサブタイプ特異的バイオマーカーの探索2017

    • Author(s)
      岩田 修永、松尾 和哉、大槻 純男、浅井 将、近藤 孝之、井上 治久、城谷 圭朗
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      ブリックホール(長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-26460200
  • [Presentation] トランスオミクスによるオーファントランスポーターSLC22A18の生理機能解明2017

    • Author(s)
      伊藤慎悟、本多玄太郎、赤澤貴憲、寺崎哲也、大槻純男
    • Organizer
      第41回 蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08373
  • [Presentation] トランスオミクスによるSLC22A18の生理機能の解明2017

    • Author(s)
      伊藤慎悟、本多玄太郎、赤澤貴憲、寺崎哲也、大槻純男
    • Organizer
      第10回トランスポーター研究会九州部会
    • Data Source
      KAKENHI-PROJECT-16K08373
  • [Presentation] オーファントランスポーターSLC22A18のタンパク質翻訳後修飾への関与2017

    • Author(s)
      伊藤慎悟、本多玄太郎、赤澤貴憲、寺崎哲也、大槻純男
    • Organizer
      日本プロテオーム学会2017
    • Data Source
      KAKENHI-PROJECT-16K08373
  • [Presentation] 高分子医薬品の小腸透過を改善させる小腸透過性環状ペプチドの同定2016

    • Author(s)
      山口駿介、伊藤慎悟、平山未央、大槻純男
    • Organizer
      第32回DDS学会
    • Place of Presentation
      静岡
    • Year and Date
      2016-06-30
    • Data Source
      KAKENHI-PROJECT-16K15162
  • [Presentation] Targeted proteomic approach to cancer biomarkers and diagnosis2016

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      Japna-US Workshop for Early Cancer Research: Biomarker Discovery for Early Cancer Detection
    • Place of Presentation
      東京
    • Year and Date
      2016-03-07
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26640092
  • [Presentation] アルツハイマー病サブグループのバイオマーカーの探索2016

    • Author(s)
      松尾 和哉、吉崎 涼平、大槻 純男、浅井 将、城谷 圭朗、近藤 孝之、井上 治久、岩田 修永
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センタ―他(宮城県・仙台市)
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-26460200
  • [Presentation] SLC22A18 is involved in the proliferation of MCF-7 human breast cancer cells by altering cellular protein expression2016

    • Author(s)
      Shingo Ito, Yu Fujino, Sumio Ohtsuki
    • Organizer
      Japan-Turkey International Symposium on Pharmaceutical and Biomedical Sciences
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      2016-10-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08373
  • [Presentation] Biomarkers of glioblastoma identified by quantitative proteomics with SWATH mass spectrometry2016

    • Author(s)
      Nakada M, Miyauchi E, Tachikawa M, Furuta T, Sabit H, Ohtsuki S, Terasaki T.
    • Organizer
      The 21st International Conference on Brain Tumor Research & Therapy
    • Place of Presentation
      Okinawa, Bankoku Shinryokan
    • Year and Date
      2016-04-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15645
  • [Presentation] 新規変異クレアチントランスポーターのクレアチン輸送活性低下とそのメカニズムの解明2016

    • Author(s)
      上村立記、伊藤慎悟、太田悠介、立川正憲、黒木未央、和田敬仁、寺崎哲也、大槻純男
    • Organizer
      第9回トランスポーター研究会九州部会
    • Place of Presentation
      宮崎
    • Data Source
      KAKENHI-PROJECT-26293035
  • [Presentation] アルツハイマー病サブグループのバイオマーカーの探索2016

    • Author(s)
      松尾 和哉、大槻 純男、浅井 将、城谷 圭朗、近藤 孝之、井上 治久、岩田 修永
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島大学(鹿児島県・鹿児島市)
    • Year and Date
      2016-12-03
    • Data Source
      KAKENHI-PROJECT-26460200
  • [Presentation] Identification of Novel Cyclic Peptides for Facilitating Intestinal Permeability of Macromolecule2016

    • Author(s)
      Shunsuke Yamaguchi, Shingo Ito, Mio Hirayama, Sumio Ohtsuki
    • Organizer
      2016 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Debver, USA
    • Year and Date
      2016-11-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15162
  • [Presentation] 経口投与型DDS開発を目指した小腸透過性環状ペプチドの同定とin vivo有効性評価2016

    • Author(s)
      伊藤慎悟、大槻純男
    • Organizer
      第39回薬物動態懇談会
    • Place of Presentation
      浜松
    • Year and Date
      2016-11-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15162
  • [Presentation] 経口投与型バイオ医薬品の開発に資する小腸透過性環状ペプチドの同定2016

    • Author(s)
      山口駿介、伊藤慎悟、平山未央、大槻純男
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2016-12-03
    • Data Source
      KAKENHI-PROJECT-16K15162
  • [Presentation] 脳クレアチン欠乏症候群に関連する新規変異クレアチントランスポーターのクレアチン輸送活性低下とそのメカニズムの解明2016

    • Author(s)
      上村立記、伊藤慎悟、太田悠介、立川正憲、平山未央、和田敬仁、寺崎哲也、大槻純男
    • Organizer
      第40回 蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Place of Presentation
      鹿児島
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PROJECT-26293035
  • [Presentation] 患者由来iPS細胞を利用したアルツハイマー病のバイオマーカーの探索2016

    • Author(s)
      岩田 修永、松尾 和哉、大槻 純男、浅井 将、近藤 孝之、井上 治久、城谷 圭朗
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-26460200
  • [Presentation] Development of biomarkers specific for Alzheimer's disease subgroups2016

    • Author(s)
      Matsuo K, Ohtsuki S, Asai M, Shirotani K, Kondo T, Inoue H, and Iwata N
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      武田薬品研修所(大阪府・吹田市)
    • Year and Date
      2016-01-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460200
  • [Presentation] 質量分析でタンパク質を測ると何が見えるか2015

    • Author(s)
      大槻 純男
    • Organizer
      第40回西日本薬剤学研究会
    • Place of Presentation
      九重
    • Year and Date
      2015-08-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-26640092
  • [Presentation] 新規変異クレアチントランスポーターの機能と発現解析2015

    • Author(s)
      上村立記、伊藤慎悟、落合祐介、立川正憲、平山未央、和田敬仁、大槻純男
    • Organizer
      第31回日本薬学会九州支部大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-28
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] 脳クレアチン欠乏症候群に関連する新規変異クレアチントランスポーターの発現・局在と輸送機能特性の解析2015

    • Author(s)
      上村立記、伊藤慎悟、太田悠介、立川正憲、平山未央、和田 敬仁、寺崎哲也、大槻純男
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-28
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] Molecular genetic study and urine analysis of Japanese patients with cerebral creatine deficiency syndromes.2015

    • Author(s)
      H. Shimbo, H. Osaka, M. Tachikawa, S. Ohtsuki, S. Ito, T. Goto, Y. Tsuyusaki, N. Aida, K. Kurosawa, Y. Kurosawa, H. Kato, K. Takano, T. Wada.
    • Organizer
      65th American Society&#160;of&#160;Human Genetics
    • Place of Presentation
      Baltimore
    • Year and Date
      2015-10-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] Changes of cellular localization and transport activity by a novel mutation in creatine transporter associated with chronic cerebral creatine depletion2015

    • Author(s)
      Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki
    • Organizer
      International Symposium on Chronic Inflammatory Diseases
    • Place of Presentation
      Kumamoto
    • Year and Date
      2015-10-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] 基礎と臨床をつなぐ次世代プロテオミクス2015

    • Author(s)
      大槻 純男
    • Organizer
      第1回川島カンファレンス
    • Place of Presentation
      岐阜
    • Year and Date
      2015-11-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-26640092
  • [Presentation] 生命科学・薬物動態研究者による定量プロテオミクス開発と応用2015

    • Author(s)
      大槻 純男
    • Organizer
      BMAS2015
    • Place of Presentation
      長崎
    • Year and Date
      2015-08-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-26640092
  • [Presentation] 質量分析でタンパク質を測ると何が見えるか2015

    • Author(s)
      大槻純男
    • Organizer
      第40回西日本薬剤学研究会
    • Place of Presentation
      九重
    • Year and Date
      2015-08-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293035
  • [Presentation] 疾患iPS細胞を用いたアルツハイマー病サブタイプ特異的バイオマーカーの探索2015

    • Author(s)
      松尾 和哉、大槻 純男、浅井 将、城谷 圭朗、近藤 孝之、井上 治久、岩田 修永
    • Organizer
      平成27年度日本生化学会九州支部例会
    • Place of Presentation
      九州大学箱崎キャンパス(福岡県・福岡市)
    • Year and Date
      2015-05-16
    • Data Source
      KAKENHI-PROJECT-26460200
  • [Presentation] 定量的標的プロテオミクスを活用したがんバイオマーカー研究2015

    • Author(s)
      大槻 純男
    • Organizer
      第22回HAB研究機構学術年会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-26640092
  • [Presentation] 「脳クレアチン欠乏症候群の臨床研究班」の取り組み2015

    • Author(s)
      和田敬仁,小坂仁,相田典子,後藤知英,露崎悠,新保裕子,加藤秀一,高野亨子,大槻純男,伊藤慎悟,立川正憲,黒澤裕子
    • Organizer
      第57回日本小児神経学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-27
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki: Changes in transport activity and cellular localization by a novel missense mutation in human creatine transporter found in Japanese cerebral creatine deficiency syndromes patients2015

    • Author(s)
      Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki
    • Organizer
      Barcelona BioMed Conference Blood Braine Barrier
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-10-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] "多"がつくと大変な標的定量プロテオミクス:一緒に楽をしましょう!2014

    • Author(s)
      大槻純男
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-26640092
  • [Presentation] 質量分析を利用したタンパク質定量による定量的生命科学への展開2014

    • Author(s)
      大槻純男
    • Organizer
      第24回WSフォーラム
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293035
  • [Presentation] MS/MS ALL (SWATH) によって進化する定量プロテオミクス2014

    • Author(s)
      大槻純男
    • Organizer
      日本プロテオーム学会2014年会
    • Place of Presentation
      筑波
    • Year and Date
      2014-07-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-26640092
  • [Presentation] Ion library accumulation by RT calibration2014

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      ABSCIEX users meeting
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2014-06-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-26640092
  • [Presentation] 定量的標的プロテオミクスによるファーマコプロテオミクスアプローチ2011

    • Author(s)
      大槻純男
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      ツインメッセ静岡、静岡(招待講演)
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-ORGANIZER-22136001
  • [Presentation] Quantification of Transporter/Enzyme Protein in Human Tissue by Mass Spectrometry : A New Path to Pharmacoproteomics (PPx)2010

    • Author(s)
      T. Terasaki, S. Ohtsuki
    • Organizer
      9th International ISSX meeting, Symposium 3 : Clinical Pharmacology of Drug Transport : From Bench to Bedside
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2010-09-05
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] Quantitative protein analysis of human glioblastoma2010

    • Author(s)
      T.Terasaki, M.Nakada, C.Ikeda, Y.Hayashi, J.Hamada, Y.Sonoda, T.Kumabe, T.Tominaga, S.Ohtsuki
    • Organizer
      Neoangiogenesis in Brain Tumours, International meeting of Signal Transduction of the Blood-Brain Barrier, Zurich 2010
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      2010-09-04
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] 次世代のファーマコプロテオミクスと中枢神経作用薬の開発2010

    • Author(s)
      大槻純男
    • Organizer
      第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会年会合同年会
    • Place of Presentation
      仙台国際センター、仙台(招待講演)
    • Year and Date
      2010-09-17
    • Data Source
      KAKENHI-ORGANIZER-22136001
  • [Presentation] Development of highly sensitive simultaneous protein quantification by LC-MS/MS and its application for the research of human disease2010

    • Author(s)
      T. Terasaki, S. Ohtsuki
    • Organizer
      28th The Japan Endocrine Society (JES)Summer Seminar on Endocrinology & Metabolism (Toward the Progress and Development of Endocrinology, Session 1 : Advancement of Research Technologies)
    • Place of Presentation
      Huis Ten Bosch, Nagasaki
    • Year and Date
      2010-07-08
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] Quantification of Transporter/Enzyme Protein in Human Tissue by Mass Spectrometry : A New Path to Pharmacoproteomics (PPx)2010

    • Author(s)
      T.Terasaki, S.Ohtsuki
    • Organizer
      9th International ISSX meeting
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2010-09-05
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] タンパク質の定量によって拓かれる新しい創薬研究2010

    • Author(s)
      大槻純男
    • Organizer
      第23回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      ホテル大観荘、松島(招待講演)
    • Year and Date
      2010-07-23
    • Data Source
      KAKENHI-ORGANIZER-22136001
  • [Presentation] 定量的標的プロテオミクスによって拓かれる新しい創薬研究への展開2010

    • Author(s)
      大槻純男
    • Organizer
      創剤フォーラム第16回シンポジウム
    • Place of Presentation
      アルカディア市ヶ谷、東京(招待講演)
    • Year and Date
      2010-10-22
    • Data Source
      KAKENHI-ORGANIZER-22136001
  • [Presentation] Development of highly sensitive simultaneous protein quantification by LC-MS/MS and its application for the research of human disease2010

    • Author(s)
      T.Terasaki, S.Ohtsuki
    • Organizer
      28th The Japan Endocrine Society (JES) Summer Seminar on Endocrinology & Metabolism (Toward the Progress and Development of Endocrinology
    • Place of Presentation
      Nagasaki
    • Year and Date
      2010-07-08
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] Multiplexed-MRM法による膜タンパク質群の一斉定量とファーマコプロテオミクスへの応用2010

    • Author(s)
      大槻純男
    • Organizer
      日本分析化学会第59年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-16
    • Data Source
      KAKENHI-PLANNED-22136014
  • [Presentation] Quantitative protein analysis of human glioblastoma, Neoangiogenesis in Brain Tumours2010

    • Author(s)
      T. Terasaki, M. Nakada, C. Ikeda, Y. Hayashi, J. Hamada, Y. Sonoda, T. Kumabe, T. Tominaga, S. Ohtsuki
    • Organizer
      International meeting of Signal Transduction of the Blood-Brain Barrier, Zurich 2010, Symposium 9
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      2010-09-04
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] 次世代のファーマコプロテオミクスと中枢神経作用薬の開発2010

    • Author(s)
      大槻純男
    • Organizer
      第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会年会合同年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-17
    • Data Source
      KAKENHI-PROJECT-22390026
  • [Presentation] タンパク質の定量によって拓かれる新しい創薬研究2010

    • Author(s)
      大槻純男
    • Organizer
      第23回,バイオメディカル,分析科学,シンポジウム
    • Place of Presentation
      松島
    • Year and Date
      2010-07-23
    • Data Source
      KAKENHI-PLANNED-22136014
  • [Presentation] 定量的標的プロテオミクスによって拓かれる新しい創薬研究への展開2010

    • Author(s)
      大槻純男
    • Organizer
      創剤フォーラム第16回シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-10-22
    • Data Source
      KAKENHI-PLANNED-22136014
  • [Presentation] Multiplexed-MRM法による膜タンパク質群の一斉定量とファーマコプロテオミクスへの応用2010

    • Author(s)
      大槻純男
    • Organizer
      日本分析化学会第59年会
    • Place of Presentation
      東北大学川内キャンパス、仙台(招待講演)
    • Year and Date
      2010-09-16
    • Data Source
      KAKENHI-ORGANIZER-22136001
  • [Presentation] New approach to drug design by quantitative membrane proteomics2009

    • Author(s)
      大槻純男, 寺崎哲也
    • Organizer
      Special lecture in Seoul Netional University
    • Place of Presentation
      Seoul
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] ファーマコプロテオミクス解析によるガン薬剤耐性機構の解明2009

    • Author(s)
      大槻純男
    • Organizer
      日本医療薬学会
    • Place of Presentation
      長崎
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Pharmacoproteomics as a novel method for the prediction of drug delivery to the brain2009

    • Author(s)
      T. Terasaki, Y. Uchida, H. Kawakami, Y. Katsukura, J. Kamiie, S. Ohtsuki
    • Organizer
      7th Retrometabolism Based Drug Design and Targeting Conference
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2009-05-11
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] New approach to drug design by quantitative membrane proteomics2009

    • Author(s)
      大槻純男
    • Organizer
      Special lecture in Seoul Netional University
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-20659021
  • [Presentation] In vitro-to-in vivo re-construction of blood-brain barrier penetration integrating P-glycoprotein absolute expression, its in vitro activity, and free fractions in plasma and brain2009

    • Author(s)
      Y. Uchida, S. Ohtsuki, J. Kamiie, T. Terasaki
    • Organizer
      8th Cerebral Vascular International Conference (CVB2009)
    • Place of Presentation
      Sendai, Japan
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] Transporter protein qunatification for the future of thransporter science. Advanced Technologies for the Future of Transporter Sciences2009

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences (IUPS2009)
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] Transporter protein quantification for the future of transporter science. Advanced Technologies for the Future of Transporter Sciences2009

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] ファーマコプロテオミクスを基盤とする新しい薬物動態研究2009

    • Author(s)
      大槻純男, 寺崎哲也
    • Organizer
      第13回薬物動態談話会セミナー
    • Place of Presentation
      つくば
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] プロテオミクス技術に基づくtailormade chemotherapyの展望2009

    • Author(s)
      川口桂、元井冬彦、藤川奈々子、有明恭平、横山智、大塚英郎、力山敏樹、片寄友、大峰健、大槻純男、寺崎哲也、江川新一、海野倫明
    • Organizer
      第47回日本癌治療学会学術会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21591766
  • [Presentation] In vitro-to-in vivo re-construction of blood-brain barrier penetration integrating P-glycoprotein absolute expression, its in vitro activity, and free fractions in plasma and brain.2009

    • Author(s)
      内田康雄、大槻純男
    • Organizer
      8th Cerebral Vascular International Conference
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] ファーマコプロテオミクス解析によるガン薬剤耐性機構の解明2009

    • Author(s)
      大槻純男, 寺崎哲也
    • Organizer
      日本医療薬学会
    • Place of Presentation
      長崎
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] 膵癌細胞における薬物輸送担体タンパク群及び関連代謝酵素の網羅的同時絶対定量解析に基づくGEM感受性・耐性規定因子の同定2009

    • Author(s)
      川口桂、元井冬彦、大峰健、大槻純男、大塚英郎, ほか
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-02
    • Data Source
      KAKENHI-PROJECT-21591766
  • [Presentation] ファーマコプロテオミクスを基盤とする新しい薬物動態研究2009

    • Author(s)
      大槻純男
    • Organizer
      第13回薬物動態談話会セミナー
    • Place of Presentation
      つくば
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] ファーマコプロテオミクス解析によるガン薬剤耐性機構の解明2009

    • Author(s)
      大槻純男, 寺崎哲也
    • Organizer
      日本薬剤学会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] プロテオミクス技術に基づくtailormade chemotherapy の展望2009

    • Author(s)
      川口桂、元井冬彦、藤川奈々子、有明恭平、横山智、大塚英郎、力山敏樹、片寄友、大峰健、大槻純男, ほか
    • Organizer
      第47回日本癌治療学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21591766
  • [Presentation] 膜タンパク質絶対発現量解析法を応用した薬物脳移行性予測への挑戦2009

    • Author(s)
      内田康雄、大槻純男
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] 膜タンパク質絶対発現量解析法を応用した薬物脳移行性予測への挑戦 : P-glycoprotein 基質に焦点を当てて2009

    • Author(s)
      内田康雄, 大槻純男, 上家潤一, 寺崎哲也
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] ファーマコプロテオミクスを基盤とする新しい薬物動態研究2009

    • Author(s)
      大槻純男
    • Organizer
      第13回薬物動態談話会セミナー
    • Place of Presentation
      つくば
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] Pharmacoproteomics in Cancer Research2009

    • Author(s)
      大槻純男, 寺崎哲也
    • Organizer
      2009 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Los Angels, USA
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] New approach to drug design by quantitative membrane proteomics2009

    • Author(s)
      S. Ohtsuki
    • Organizer
      Special lecture in Seoul National University
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Multiplexed-MRMによるヒトメンブレンプロテオミクス解析-トリプル四重極質量分析計を用いた新しいアプローチによる膜タンパク質群の高感度同時定量-2009

    • Author(s)
      大槻純男
    • Organizer
      日本ヒトプロテオーム機構第7回大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20659021
  • [Presentation] New approach to drug design by quantitative membrane proteomics2009

    • Author(s)
      S. Ohtsuki
    • Organizer
      Special lecture in Seoul Netional University
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] 標的プロテオミクスによる膜タンパク質研究の新たな展開2008

    • Author(s)
      大槻純男
    • Organizer
      BMA2008、若手シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2008-08-06
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] Quantitative targeted proteomics as a new strategy for the blood-brain barrier research2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      2008 the Pharmaceutical Society of Korea Metting
    • Place of Presentation
      Jeju, Korea
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Pharmacoproteomics in Cancer Research2008

    • Author(s)
      S. Ohtsuki, R. Iwase, J. Kamiie, K. Ohmine, H. Harigae, T. Terasaki
    • Organizer
      2009 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Los Angels, CA, USA
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] 標的プロテオミクスによる膜タシパク質研究の新たな展開2008

    • Author(s)
      大槻純男
    • Organizer
      BMA2008、若手シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2008-08-06
    • Data Source
      KAKENHI-PROJECT-20659021
  • [Presentation] Award Lecture for New Investigator Award2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      2nd ISSX Asian Pacific Regional Meeting
    • Place of Presentation
      Shanghai, China
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Targeted proteomics of the BBB tight junction2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      Gordon Research conference "Barriers of the CNS"
    • Place of Presentation
      Tilton, NH. USA
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Quantitative Targeted Proteomicsによる膜タンパク質の網羅的定量技術の開発と応用2008

    • Author(s)
      大槻純男
    • Organizer
      第5回東北大学バイオサイエンスシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Award Lecture for New Investigator Award2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      2nd ISSX Asian Pacific Regional Meeting
    • Place of Presentation
      Shanghai, Chaina
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Multiplexed-MRM法による遺伝子情報からの膜タンパク質群の絶対発現量プロフアイル解析2008

    • Author(s)
      大槻純男
    • Organizer
      アプライドバイオシステムズ・タンパク質研究・プロテオミクス研究セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-12
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] Reconstruction of in vivo P-glycoprotein activity from in vitro infnrmatinn by tarcreted absolute nroteomics2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      2nd World Conference on Magic Bullets (Ehrlich II)
    • Place of Presentation
      Nurnberg, Germany
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] Award Lecture for New Investigator Award2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      2nd ISSX Asian Pacific Regional Meeting
    • Place of Presentation
      Shanghai, Chaina
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] Award Lecture for New Investigator Award.2008

    • Author(s)
      Sumio Ohtsuki
    • Organizer
      2nd ISSX Asian Pacific Regional Meeting
    • Place of Presentation
      上海,中国
    • Year and Date
      2008-05-12
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] ABCA1 deficiency does not affect the amyloid-beta elimination across the blood-brain barrier2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      Gordon Research conference "Barriers of the CNS"
    • Place of Presentation
      Tilton, NH. USA
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Reconstruction of in vivo P-glycoprotein activity from in vitro information by targeted absolute proteomics2008

    • Author(s)
      S. Ohtsuki, Y. Uchida, T. Terasaki
    • Organizer
      2nd World Conference on Magic Bullets (Ehrlich II)
    • Place of Presentation
      Nurnberg, Germany
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] 標的プロテオミクスによる膜タンパク質研究の新たな展開2008

    • Author(s)
      大槻純男
    • Organizer
      BMA2008、若手シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2008-08-06
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Multiplexed-MRM法による遺伝子情報からの膜タンパク質群の絶対発現量プロフアイル解析2008

    • Author(s)
      大槻純男
    • Organizer
      アプライドバイオシステムズ・タンパク質研究・プロテオミクス研究セミナー
    • Place of Presentation
      東京
    • Year and Date
      2008-11-14
    • Data Source
      KAKENHI-PROJECT-18109002
  • [Presentation] Reconstruction of in vivo BBB P-glycoprotein function based on its absolute expression amount and in vitro transport activity2008

    • Author(s)
      Y. Uchida, J. Kamiie, S. Ohtsuki, T. Terasaki
    • Organizer
      Gordon Research conference "Barriers of the CNS"
    • Place of Presentation
      Tilton, NH. USA
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] Blood-Brain Barrier Pharmacoproteomics (PPx): Targeted absolute proteomics-based pharmacokinetics as a new path for the blood-brain barrier research2008

    • Author(s)
      T. Terasaki, Y. Uchida, J. Kamiie, S. Ohtsuki
    • Organizer
      BLOOD-BRAIN BARRIER CONSORTIUM CLUB Symposium: 'The impact of efflux transports on CNS drug distribution'
    • Place of Presentation
      Gordon Museum, Hodgkin Building, King's College Guy's Campus, London, United Kingdom
    • Year and Date
      2008-11-14
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Targeted proteomics analysis of tight junction proteins expressed at the blood-brain barrier2008

    • Author(s)
      S. Ohtsuki, S. Murata, Y. Katsukura, J. Kamiie, P.O. Couraud, T. Terasaki
    • Organizer
      The 11th international symposium on "Signal transduction in the Blood-Brain Barriers"
    • Place of Presentation
      Amsterdam, Netherlands
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Reconstruction of P-glycoprotein function at blood-brain barrier based on its absolute expression amount and in vitro transport activity2008

    • Author(s)
      Y. Uchida, S. Ohtsuki, J. Kamiie, T. Terasaki
    • Organizer
      2008 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Atlanta, GA, USA
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] 有機アニオントランスポーター oatp2を介した24(S)hydroxycholesterol の生体膜輸送2007

    • Author(s)
      大槻純男, 伊藤慎悟, 松田明大, 堀里子, 阿部高明, 寺崎哲也
    • Organizer
      第30回日本分子生物学会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] ain barrier transport protein for the brain drug delivery2007

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      6th Retrometabolism Based Drug Design and Targeting Conference
    • Place of Presentation
      Budapest, Hungary
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Functional expression of transporters for organic anion at the blood-brain barrier2007

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      7th Cerebral Vascular Biology International Conference
    • Place of Presentation
      Ottawa, Canada
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] 有機アニオントランスポーターoatp2を介した24(S)hydroxycholesterolの生体膜輸送2007

    • Author(s)
      大槻 純男
    • Organizer
      第30回日本分子生物学会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Data Source
      KAKENHI-PROJECT-19390038
  • [Presentation] Special Lecture: Quantitative proteomics in transporter biology as a new strategy of the drug delivery research2007

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      International Workshop and Symposium on Transport, Metabolism and Disposition
    • Place of Presentation
      Seoul, Korea
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Quantitative proteomics as a path to new blood-brain barrier research2007

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      Tenth Symposium Signal Transduction in the Blood-Brain Barriers
    • Place of Presentation
      Potsdam, Germany
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Quantitative and Simultaneous LC-MS/MS Analysis for Membrane Proteins: Its Application for the Blood-Brain Barrier Biology2006

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      Invited lecture at Seminar of Institut Cochin
    • Place of Presentation
      Paris, France
    • Year and Date
      2006-12-22
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Quantitative proteomics for membrane proteins as a new strategy for the blood-brain barrier biology2006

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      Invited lecture at Seminar of Universite d'Atrois
    • Place of Presentation
      Lens, France
    • Year and Date
      2006-12-20
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] Brain-to-blood efflux transporters at the blood brain barrier as a CNS detoxifying system2005

    • Author(s)
      T. Terasaki, S. Ohtsuki
    • Organizer
      1th Indo-Japanese Conference on Advances in Pharmaceutical Research and Technology - with special emphasis on Drug Discovery and Drug Delivery
    • Place of Presentation
      Mumbai, India
    • Data Source
      KAKENHI-PROJECT-17081002
  • [Presentation] ヒトクレアチントランスポーター変異症例におけるクレアチン輸送機能の解明

    • Author(s)
      上村立記、伊藤慎悟、落合祐介、立川正憲、平山未央、和田敬仁、大槻純男
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26293035
  • [Presentation] 新規変異クレアチントランスポーターの機能と発現解析

    • Author(s)
      上村立記、伊藤慎悟、落合祐介、立川正憲、平山未央、和田敬仁、大槻純男
    • Organizer
      第31回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-05 – 2014-12-06
    • Data Source
      KAKENHI-PROJECT-26293035
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