Shuto Satoshi 周東智

… Alternative Names

SHUTO Satoshi 周東智

SHUTOH Satoru 周東智

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Researcher Number	70241346
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 名誉教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 北海道大学, 薬学研究院, 名誉教授 2016 – 2022: 北海道大学, 薬学研究院, 教授 2015 – 2016: 北海道大学, 大学院薬学研究院, 教授 2015: 北海道大学, 大学院薬学研究院・創薬有機化学研究室, 教授 2011 – 2015: 北海道大学, 薬学研究科(研究院), 教授 … More 2009 – 2012: Hokkaido University, 大学院・薬学研究院, 教授 2006 – 2007: 北海道大学, 大学院・薬学研究院, 教授 2006: 北海道大学, 大学院薬学研究院, 教授 2004 – 2005: Hokkaido Univ., Grad.School of Pharm.Sci., Prof., 大学院・薬学研究科, 教授 1999 – 2004: Grad. School of Pharm. Sci., Hokkaido University, Associate Prof., 大学院・薬学研究科, 助教授 1998: 北大, 薬学部, 助教授 1997: 北海道大学, 歯学部, 助教授 1993 – 1997: 北海道大学, 薬学部, 助教授 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / 医薬分子機能学 / Chemical pharmacy / Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological Sciences / Science and Engineering Except Principal Investigator Biological pharmacy / 医薬分子機能学 / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 56020:Orthopedics-related … More / Drug development chemistry / Pharmacology in pharmacy / Ophthalmology / Functional basic dentistry / Physical pharmacy Less
Keywords	Principal Investigator シクロプロパン / 分子設計 / cADPR / 配座制御 / セカンドメッセンジャー / リン脂質 / ヌクレオシド / ラジカル反応 / 細胞内情報伝達系 / カルシウム … More / ペプチドミメティクス / 三次元多様性 / 反応機構 / 三次元的多様性 / 創薬リード / リンパ節転移 / 配座制限誘導体 / 高分子間相互作用 / αヘリックス / ホールダマー / 膜透過性ペプチド / 環状ペプチド / タンパク質間相互作用 / ムスカリン受容体 / トルテロジン / レジデンスタイム / ペプチドミイメティクス / ライブラリー / レゾルビン / second messenger / calcium / intracellular signal transduction / H_1 receptor / H_3 receptor / histamine / drug design / cyclopropane / conformationally restricted analogue / antagonist / agonist / 受容体サブタイプ / 創薬 / H_4受容体 / H_3受容体 / ヒスタミン / アンタゴニスト / アゴニスト / Nucleoside / Anti-HIV agent / Atom transfer / Radical reaction / Ethynyl group / Silicon tether / 生理活性物質 / アトムトランスファー反応 / エチニル基 / transition state / Tamao oxidation / silicon tether / ring-enlargement / reaction mechanism / radical reaction / nucleoside / C-glycoside / IP3 / ケイ素 / ラジカル / 遷移状態 / 玉尾酸化 / シリコンテザー / 環拡大 / C-グリコシド / クアトロフェニル / 二量等価体 / ファゴサイトーシス / ホスファチジルセリン / BASE阻害剤 / プロテアソーム阻害剤 / BGT-1 阻害剤 / 光反応 / Huisegen反応 / β細胞 / 医薬分子設計 / Ca^<2+>動員 / プロドラッグ / 発達障害 / オキシトシン / 活性配座 / ペプチドミメティックス / メラノコルチン受容体 / Grb2 / MC4 / ペプチドミメティック / βターン / PLC / PI3K / イノシトールリン脂質 / シクロプロパンアミノ酸 / プロテアソーム / ベラクトシン / ユビキチン / ピロリン酸 / 環化反応 / ヌクレオチド / cADP-リボース / CNDAC / 制がん剤 / Drug Delivery System / がん化学療法 / ターゲッティング / 不斉合成 / 遅発性神経細胞死 / 脳虚血 / グルタミン酸受容体 / NMDA受容体 / リンパ指向性 / 制癌剤 / 5-フルオロウリジン / ターゲッティグ … More Except Principal Investigator GDNF / 遺伝子 / 核酸 / クロスリンク / 核酸医薬 / miRNA / RNA / アンチセンス / 脳虚血 / 学習記憶障害 / senescence accelerated mouse (SAM) / 老化促進モデルマウス / 神経細胞死 / PEPT1 / Caco-2 / アポトーシス / サイクリックADPリボース / ネオカルチノスタチン / レチノイド / 代謝拮抗剤 / 生体高分子 / オリゴヌクレオチド / 血液脳脊髄関門 / 2次損傷 / 神経保護 / 血液脊髄関門 / 脊髄損傷 / 神経保護薬 / antisense / oligonucleotide therapy / oligonucleotide / microRNA / 創薬 / トランスポーター / ＧＡＢＡ / 有機化学 / 薬理学 / 脳・神経 / （プロ）レニン受容体 / 受容体結合プロレニン / 網脈絡膜疾患 / 血管新生 / レニン・アンジオテンシン系 / (プロ)レニン受容体 / 受容体結合プロレニン系 / 細胞内シグナル / FRET / 蛍光センサー / アセチルコリン / イノシトール三リン酸 / カルシウム / イメージング / brain ischemia / CREB / phosphatididylinositol 4-kinase / neurotrophic factor / learning deficiency / quantitative trait Loci analysis (QTL) / Senescence-accelerated mouse (SAM) / ハマボウフウ / ミエリン / サイトカイン / インターロイキン-1β / Phosphatidylinositol 4-kinase / phosphatidylinositol 4-kinase / 神経栄養因子 / グリア細胞株由来 / 連鎖解析 / phosphodiester bond / thermal stability / oligodeoxyribonucleotide / 4'-branched thymidine / radical cyclization / antisense molecule / endo-nuclease / exo-nuclease / RNaseH / ラジカル反応 / マラリア / リン酸ジエステル結合 / 熱的安定性 / RNase H / ヌクレアーゼ抵抗性 / アンチセンス核酸 / aging / neuronal death / ischemia / depressive behavior / learning impairments / senescence accelerated mouse / NO / アポートシス / ストレス刺激 / 受容体 / 神経伝達物質 / 虚血モデル / 促進老化マウス / グルタミンシンテターゼ / differential display法 / senescence accelerated mouse(SAM) / 加齢 / うつ病 / channel blocker / cyclopropane / conformational restriction / neuronal cell death / NMDA receptor / 分子設計 / 遅発性神経細胞死 / セロトニントランスポーター / 立体配座固定 / アンタゴニスト / NMDAレセプター / チャネルブロッカー / シクロプロパン / 配座制御 / NMDA受容体 / anti-cancer drugs / multi-efflux transporter / methoxylate / fluorescent substrate / Peptide transporter / フローレセッイン / ロ-ダミン123 / ピレン / 平面脂質二分子膜 / リゾリン脂質 / 膜輸送 / 腸管吸収 / ザルコシン / Sw620 / Caco2 / FITC / ダイペプチド / 蛍光性輸送基質 / 抗ガン剤 / 多剤排出輸送体 / メトキサレート / 蛍光生輸送基質 / ペプチドトランスポータ / タキソ-ル / ハリコンドリンB / タキリ-ル / ハリコンンドリンB Less

Development of a novel neuroprotective drug by optimizing VCP compounds
- Principal Investigator
  
  Funaki Tomo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Yamagata Prefectural Yonezawa University of Nutrition Sciences
  Hokkaido University
Complex formation between RNA cleaving-enzyme and antisense and its application to regulation of long non-coding RNAs.
- Principal Investigator
  
  Yasuo Komatsu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Medicinal chemistry for developing molecules regulating interactions between biological macromoleculesPrincipal Investigator
- Principal Investigator
  
  Shuto Satoshi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Hokkaido University
Development of new drugs targeting receptor-associated protein system for ocular disorders
- Principal Investigator
  
  Ishida Susumu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Hokkaido University
A Versatile Strategy for Developing Long-Acting Ligands by Ligand-Phospholipid ConjugationPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Development of anti-miRNA oligonucleotides on the basis of structure control.
- Principal Investigator
  
  Komatsu Yasuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Medicinal chemistry studies based on the three-dimensional structural diversity-oriented molecular design of pharmacologically active compoundsPrincipal Investigator
- Principal Investigator
  
  Shuto Satoshi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Elucidation of neural GABA transporter function by developing novel subtype-selective inhibitors
- Principal Investigator
  
  MINAMI Masabumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Hokkaido University
Development of bioimaging methods for intra- and intercellular messengers
- Principal Investigator
  
  Tanimura Akihiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido
Design and synthesis of phosphatidylserine dimers with antitumor effect via the phagocytosis-inducing propertyPrincipal Investigator
- Principal Investigator
  
  SHUTO satoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Medicinal chemical study by the three-dimensional structural diversity-oriented strategy based on the characteristic steric and stereoelectronic features of cyclopropanePrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Investigation of the mechanism of insulin secretion via CaPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Useful β-turn mimetics having three-dimensional diversityPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
発達障害発症機序の解析と治療薬創製研究Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
非イノシトール型イノシトールリン脂質ミミックの創製研究Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Development of ligands active specifically in intracellular Ca^<2+>-mobilizing second messenger systemPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
配座制御に基づく分子設計:ユビキチン/プロテアソーム系を標的とする制がん剤の創製Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Development of histamine H_3 receptor selective ligands based on the versatile chiral cyclopropane units.Principal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  HOKKAIDO UNIVERSITY
大環状ピロリン酸構造を持つサイクリックADP-リボース類縁化合物の効率的合成Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Development of New Silicon Tethers and Their Application to the Synthesis of Anti-HIV NucleosidesPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Preparation of animal model with higher brain dysfunction : studies on evaluation methods of active chemicals
- Principal Investigator
  
  NOMURA Yasuyuki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Design of Nuclease-resistant Antisense Molecules Based on the X-ray Structures of Some Nucleases
- Principal Investigator
  
  MATSUDA Akira
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  Hokkaido University
A Noven Radical Ring-Enlargement Reaction : The Reaction Mechanism and the Medicinal Chemical ApplicationPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University
リンパ節転移がんに有効な制がん剤ドラッグデリパリ-システムの開発Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
新規セカンドメッセンジャーCADP−リボースの安定な活性等価体の設計と合成Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Hokkaido University
Development of model animals and cells for neuronal disease
- Principal Investigator
  
  NOMURA Yasuyuki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
生体高分子機能を修飾する抗がん化合物の合成と作用解析
- Principal Investigator
  
  松田彰
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
A study on development of inhibitors for neuronal cell death
- Principal Investigator
  
  MATSUDA Akira
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  HOKKAIDO UNIVERSITY
生体高分子機能を修飾する抗がん化合物の合成と作用解析
- Principal Investigator
  
  MATUDA Akira
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
リンパ節転移がんに対する化学療法剤の開発Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Drug Delivery System Utilizing Transporters That Recognize Substrates of Relatively Large Molecular Sizes
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
シクロプロパン環の立体構造特性に基づく分子設計:NMDA受容体特異的拮抗剤の合成Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Hokkaido University
リンパ系への薬物ターゲッティングの合成化学的アプローチPrincipal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Hokkaido University

[Book] 有機医薬分子論2011
- Author(s)
  周東智
- Total Pages
  320
- Publisher
  京都廣川書店出版
- Data Source
  KAKENHI-PROJECT-21390028
[Book] オングストロムの分子設計ナノバイオエンジニアリング,化学フロンティア(杉本直己編)2004
- Author(s)
  周東智
- Total Pages
  13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590096
[Book] オングストロムの分子設計ナノバイオエンジニアリング,化学フロンティア(杉本直己編)2004
- Author(s)
  周東智
- Total Pages
  13
- Data Source
  KAKENHI-PROJECT-15590096
[Book] オングストロムの分子設計ナノバイオエンジニアリング,化学フロンティア(杉本直己編)2004
- Author(s)
  周東智
- Total Pages
  13
- Data Source
  KAKENHI-PROJECT-16023205
[Journal Article] Resolvin E3 ameliorates insulin resistance via the phosphatidylinositol‐3‐kinase/Akt signaling pathway in adipocytesive2022
- Author(s)
  281.T. Shimizu, T. Saito, H. Aoki-Saito, H. Ikeda, T. Nakakura, H.to Fukuda, S.yota Arai, K.ouichi Fujiwara, Y.asuyo Nakajima, K. Horiguchi, S. Yamada, E. Ishida, T. Hisada, S. Shuto, M. Yamada
- Journal Title
  
  FASEB J.
  
  Volume: 36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] Discovery of Gut-Restricted Small Molecule Inhibitors of Intestinal Sodium Dependent Phosphate Transport Protein 2b (NaPi2b) for the Treatment of Hyperphosphatemia2022
- Author(s)
  84.M. Maemoto, Y.i Hirata, J. Kazuya Narushima, Y.Tsuji,†H. Takada,A. Yanagisawa, S. Shuto,
- Journal Title
  
  J. Med.Chem.
  
  Volume: 65 Pages: 1946-1960
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] S. Helix-forming aliphatic homo-δ-peptide foldamers based on the conformational restriction effects of cyclopropane.2022
- Author(s)
  89.Nagata, M.; Watanabe, M.; Doi, R.; Uemura, M.; Ochiai, N.; Ichinose, W.; Fujiwara, K.; Kameda, T.; Sato, Y.; Takeuchi, K.; Shuto,
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: - Issue: 5 Pages: 970-980
- DOI
  10.1039/d2ob01715f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-22K06494, KAKENHI-PROJECT-20H03378
[Journal Article] Development of Potent non-Acylhydrazone Inhibitors of Intestinal Sodium-Dependent Phosphate Transport Protein 2b (NaPi2b).2022
- Author(s)
  87.M. Maemoto, Y. Hirata, S. Hosoe, J. Ouchi, M. Uchii, H. Takada, E, Akizawa, A. Yanagisawa, S. Shuto,
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 71 Pages: 116944-116944
- DOI
  10.1016/j.bmc.2022.116944
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] esolvin E3 ameliorates insulin resistance via the phosphatidylinositol‐3‐kinaseAkt signaling pathway in adipocytesive2022
- Author(s)
  T. Shimizu, T. Saito, H. Aoki-Saito, H. Ikeda, T. Nakakura, H.to Fukuda, S.yota Arai, K.ouichi Fujiwara, Y.asuyo Nakajima, K. Horiguchi, S. Yamada, E. Ishida, T. Hisada, S. Shuto, M. Yamada
- Journal Title
  
  FASEB J.
  
  Volume: 36
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] Synthesis of γ-Aminobutyric Acid (GABA) Analogues Conformationally Restricted by Bicyclo[3.1.0]hexane/hexene or [4.1.0]Heptane/heptene Backbones as Potent Betaine/GABA Transporter Inhibitors2022
- Author(s)
  Keisuke Mitsui, Maria E. K. Lie, Naoki Saito, Koichi Fujiwara, Mizuki Watanabe, Petrine Wellendorph, Satoshi Shuto
- Journal Title
  
  Organic Letters
  
  Volume: 24 Issue: 23 Pages: 4151-5154
- DOI
  10.1021/acs.orglett.2c01346
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06494, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-19K06965
[Journal Article] Design and Synthesis of Cyclopropane Congeners of Resolvin E3, an Endogenous Pro-Resolving Lipid Mediator, as Its Stable Equivalents.2022
- Author(s)
  (2)Arai S, Fujiwara K, Kojima M, Aoki-Saito H, Yatomi M, Saito T, Koga Y, Fukuda H, Watanabe M, Matsunaga S, Hisada T, Shuto S
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 87(15) Issue: 15 Pages: 10501-10508
- DOI
  10.1021/acs.joc.2c01110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08404, KAKENHI-PROJECT-22K06494, KAKENHI-PROJECT-22K08227, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-18K08382, KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-20K06941, KAKENHI-PROJECT-21K15215
[Journal Article] Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside2022
- Author(s)
  H. Higashida, K. Furuhara, O. Lopatina, M. Gerasimenko, O. Hori, T. Hattori, Y. Hayashi, S. M. Cherepanov, A. A. Shabalova, A. B. Salmina, K. Minami, T. Yuhi, C. Tsuji, P. Y. Fu, Z. Liu, S. Luo, A. Zhang, S. Yokoyama, S. Shuto, M. Watanabe, K. Fujiwara, S. Munesue, A. Harashima, Y. Yamamoto
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 16 Pages: 858070-858070
- DOI
  10.3389/fnins.2022.858070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06494, KAKENHI-PROJECT-22K18540, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-21H02695, KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-20K07323
[Journal Article] Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT12021
- Author(s)
  280.S. Kickinger, M. E. K. Lie, A. Suemasa, A. Al-Khawaja, K. Fujiwara, M. Watanabe, K. S. Wilhelmsen, C. B. Falk-Petersen, B. Frolund, S. Shuto, G. F. Ecker, P. Wellendorth
- Journal Title
  
  Front. Chem
  
  Volume: 16
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] Design, synthesis, and monoamine oxidase inhibitory activity of (+)-cinchonaminone and its simplified derivatives.2021
- Author(s)
  278.Y. Sato, N. Oyabe, N. Ogawa, A, T. Suzuki , S. Aoyama, H. Nakamura, H. Fujioka, S. Shuto, M. Arisawa
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 11 Pages: 22601-22602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as RORγt inverse agonists showing favorable ADME profile2021
- Author(s)
  Nakajima Ryota、Oono Hiroyuki、Kumazawa Keiko、Ida Tomohide、Hirata Jun、White Ryan D.、Min Xiaoshan、Guzman-Perez Angel、Wang Zhulun、Symons Antony、Singh Sanjay K.、Mothe Srinivasa Reddy、Belyakov Sergei、Chakrabarti Anjan、Shuto Satoshi
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 36 Pages: 127786-127786
- DOI
  10.1016/j.bmcl.2021.127786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03372
[Journal Article] Synthesis of Resolvin E1 and Its Conformationally Restricted Cyclopropane Congeners with Potent Anti-Inflammatory Effect2021
- Author(s)
  274.K. Ishimura, H. Fukuda, K. Fujiwara, R. Muromoto, K. Hirashima, Y. Murakami, M. Watanabe, J. Ishihara, T. Matsuda, S. Shuto
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 12 Pages: 1464-1469
- NAID
  120007186305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] Conformational Restriction of Histamine with a Rigid Bicyclo[3.1.0]hexane Scaffold Provided Selective H3 Receptor Ligands2020
- Author(s)
  Watanabe Mizuki、Kobayashi Takaaki、Ito Yoshihiko、Yamada Shizuo、Shuto Satoshi
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 16 Pages: 3562-3562
- DOI
  10.3390/molecules25163562
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-19H01014
[Journal Article] Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors.2020
- Author(s)
  Y. Kimura, Z. Shu, M. Ito, N. Abe, K. Nakamoto, F.Tomoike, S. Shuto, Y. Ito, H. Abe,
- Journal Title
  
  Chem. Commun.
  
  Volume: 56 Pages: 466-469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors2020
- Author(s)
  Kimura Yasuaki、Shu Zhaoma、Ito Mika、Abe Naoko、Nakamoto Kosuke、Tomoike Fumiaki、Shuto Satoshi、Ito Yoshihiro、Abe Hiroshi
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 3 Pages: 466-469
- DOI
  10.1039/c9cc04872c
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15713, KAKENHI-PUBLICLY-18H04398, KAKENHI-PROJECT-18K14357, KAKENHI-PROJECT-19H01014
[Journal Article] Discovery of [1,2,4]Triazolo[1,5a]pyridine Derivatives as Potent and Orally Bioavailable RORt Inverse Agonists.2020
- Author(s)
  2.R. Nakajima, H. Oono, S. Sugiyama, Y. Matsueda, T. Ida, S. Kakuda, J. Hirata, A. Baba, A. Makino, R. Matsuyama, R. D. White, R. Wurz, Y. Shin, X. Min, A. G.-Perez, Z. Wang, A. Symons, S. K. Singh, S. R. Mothe, S. Belyakov, A. Chakrabarti, S. Shuto,
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 11 Issue: 4 Pages: 528-534
- DOI
  10.1021/acsmedchemlett.9b00649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] A Macrocyclic Peptide Library with a Structurally Constrained Cyclopropane‐containing Building Block Leads to Thiol‐independent Inhibitors of Phosphoglycerate Mutase2020
- Author(s)
  Okuma Rika、Kuwahara Tomoki、Yoshikane Takafumi、Watanabe Mizuki、Dranchak Patricia、Inglese James、Shuto Satoshi、Goto Yuki、Suga Hiroaki
- Journal Title
  
  Chemistry - An Asian Journal
  
  Volume: 15 Issue: 17 Pages: 2631-2636
- DOI
  10.1002/asia.202000700
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-19K22243, KAKENHI-PLANNED-16H06444, KAKENHI-PROJECT-20H02866
[Journal Article] Design and Synthesis of Benzene Congeners of Resolvin E2, a Proresolving Lipid Mediator, as Its Stable Equivalents2020
- Author(s)
  Murakami Yuto、Fukuda Hayato、Muromoto Ryuta、Hirashima Koki、Ishimura Kohei、Fujiwara Koichi、Ishihara Jun、Matsuda Tadashi、Watanabe Mizuki、Shuto Satoshi
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 11 Issue: 4 Pages: 479-484
- DOI
  10.1021/acsmedchemlett.9b00596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08360, KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-20K06941, KAKENHI-PROJECT-19H01014
[Journal Article] Synthesis of oxytocin derivatives lipidated via a carbonate or carbamate linkage as a long-acting therapeutic agent for social impairment-like behaviors2019
- Author(s)
  Cherepanov Stanislav M.、Miura Risako、Shabalova Anna A.、Ichinose Wataru、Yokoyama Shigeru、Fukuda Hayato、Watanabe Mizuki、Higashida Haruhiro、Shuto Satoshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 15 Pages: 3358-3363
- DOI
  10.1016/j.bmc.2019.06.018
- NAID
  120007126060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-17K08360
[Journal Article] Synthesis of 1,1,2-Trisubstituted Cyclopropane Nucleosides in Enantiomerically Pure Forms.2019
- Author(s)
  D. Fushihara, H. Fukuda, H. Abe, S. Shuto
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids
  
  Volume: 38 Issue: 12 Pages: 921-941
- DOI
  10.1080/15257770.2019.1625380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-17K08360, KAKENHI-PROJECT-16H05106
[Journal Article] Synthesis of Enantiomerically Pure 1,2,3-Trisubstituted Cyclopropane Nucleosides Using Pd-Catalyzed Substitution via Directing Group-Mediated C(sp3)?H Activation as a Key Step2019
- Author(s)
  Minami Takaaki、Fukuda Kohtaro、Hoshiya Naoyuki、Fukuda Hayato、Watanabe Mizuki、Shuto Satoshi
- Journal Title
  
  Organic Letters
  
  Volume: 21 Issue: 3 Pages: 656-659
- DOI
  10.1021/acs.orglett.8b03785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08360, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-17K15476, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-16H05106
[Journal Article] Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold.2019
- Author(s)
  K. Yamamoto, T. Tamura, R. Nakamura†, S. Suzuki, J. Saito, K.Ueno, S. Shuto,
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 37 Issue: 22 Pages: 115122-115137
- DOI
  10.1016/j.bmc.2019.115122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells2019
- Author(s)
  Shishido Yuko、Tomoike Fumiaki、Kuwata Keiko、Fujikawa Haruka、Sekido Yoshitaka、Murakami‐Tonami Yuko、Kameda Tomoshi、Abe Naoko、Kimura Yasuaki、Shuto Satoshi、Abe Hiroshi
- Journal Title
  
  ChemBioChem
  
  Volume: 20 Issue: 7 Pages: 900-905
- DOI
  10.1002/cbic.201800671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14356, KAKENHI-PROJECT-17K15479, KAKENHI-PUBLICLY-18H04398, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-18K06979, KAKENHI-PROJECT-15K08325
[Journal Article] Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors2019
- Author(s)
  Ichinose W, Cherepanov SM, Shabalova AA, Yokoyama S, Yuhi T, Yamaguchi H, Watanabe A, Yamamoto Y, Okamoto H, Horike S, Terakawa J, Daikoku T, Watanabe M, Mano N, Higashida H, Shuto S
- Journal Title
  
  J Med Chem
  
  Volume: - Issue: 7 Pages: 3297-3310
- DOI
  10.1021/acs.jmedchem.8b01691
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-18K06742, KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-19H00388
[Journal Article] Synthesis of Chiral cis-Cyclopropane Bearing Indole and Chromone as Potential TNFα Inhibitors2018
- Author(s)
  Kanada Ryutaro、Tanabe Makoto、Muromoto Ryuta、Sato Yukina、Kuwahara Tomoki、Fukuda Hayato、Arisawa Mitsuhiro、Matsuda Tadashi、Watanabe Mizuki、Shuto Satoshi
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 83 Issue: 15 Pages: 7672-7682
- DOI
  10.1021/acs.joc.8b00466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08360, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-17K15476, KAKENHI-PROJECT-16H05106, KAKENHI-PROJECT-15KT0063, KAKENHI-PUBLICLY-18H04260, KAKENHI-PROJECT-26288051
[Journal Article] Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice2018
- Author(s)
  Deyama Satoshi、Shimoda Kento、Ikeda Hiroyuki、Fukuda Hayato、Shuto Satoshi、Minami Masabumi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 138 Issue: 1 Pages: 86-88
- DOI
  10.1016/j.jphs.2018.09.006
- NAID
  120006540074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08360, KAKENHI-PROJECT-15H02495
[Journal Article] Ligand-Phospholipid Conjugation: a Versatile Strategy for Developing Long-Acting Ligands that Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand2018
- Author(s)
  Kawamura, Y. Ito, T. Hirokawa, E. Hikiyama, S. Yamada, S. Shuto
- Journal Title
  
  J. Med. Chem.
  
  Volume: 61 Issue: 9 Pages: 4020-4029
- DOI
  10.1021/acs.jmedchem.8b00041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-16H05106
[Journal Article] Design and synthesis of cyclopropane-based conformationally restricted GABA analogues as selective inhibitors for betaine/GABA transporter 12018
- Author(s)
  Suemasa Akihiro、Watanabe Mizuki、Kobayashi Takaaki、Suzuki Hiroe、Fukuda Hayato、Minami Masabumi、Shuto Satoshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 28 Issue: 20 Pages: 3395-3399
- DOI
  10.1016/j.bmcl.2018.08.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08360, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-17K15476
[Journal Article] Ligand-Phospholipid Conjugation: a Versatile Strategy for Developing Long-Acting Ligands that Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand2018
- Author(s)
  S. Kawamura, Y. Ito, T. Hirokawa, E. Hikiyama, S. Yamada, S. Shuto
- Journal Title
  
  J. Med. Chem
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15136
[Journal Article] Design and Synthesis of Histamine H3/H4 Receptor Ligands with a Cyclopropane Scaffold. Bioorg2018
- Author(s)
  Watanabe, T. Kobayashi, Y. Ito, H. Fukuda, S. Yamada, M. Arisawa, S. Shuto,
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 28 Pages: 3630-3633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Development of dihydrodibenzooxepine PPAR gamma ligands of a novel binding mode as anticancer agents: Effective mimicry of chiral structures by olefinic E/Z-isomers2018
- Author(s)
  Yamamoto, T. Tamura, K. Henmi, T. Kuboyama, A. Yanagisawa, M. Matsubara, Y. Takahashi, M. Suzuki, J. Saito, K.Ueno, S. Shuto
- Journal Title
  
  J. Med. Chem.
  
  Volume: ６１ Issue: 22 Pages: 10067-10083
- DOI
  10.1021/acs.jmedchem.8b01200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] An Entry to Chiral 1,1,2,3-Tetrasubstituted Arylcyclopropanes by Pd(II)-Catalyzed Arylation via Directing Group-Mediated C(sp3)-H Activation.2017
- Author(s)
  N. Hoshiya, M. Kondo, H. Fukuda, M. Arisawa, J. Uenishi, S. Shuto
- Journal Title
  
  J. Org. Chem.
  
  Volume: 82 Issue: 5 Pages: 2535-2544
- DOI
  10.1021/acs.joc.6b02935
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-15KT0063, KAKENHI-PUBLICLY-16H01026
[Journal Article] Highly Conformationally-Restricted Cyclopropane Tethers with three-Dimensional Structural Diversity Drastically Enhance the Cell-Permeability of Cyclic Peptides2017
- Author(s)
  K. Matsui, Y. Kido, R. Watari, Y. Kashima, Y. Yoshida, S. Shuto
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 23 Issue: 13 Pages: 1-9
- DOI
  10.1002/chem.201604946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Structure-specific Effects of Lipidated Oxytocin Analogs on Intracellular Calcium Levels, Parental Behavior, Plasma and Cerebrospinal Fluid Oxytocin Concentrations in Mice.2017
- Author(s)
  S. M. Cherepanov, S. Yokoyama, A. Mizuno, W. Ichinose, O. Lopatina, A. A. Shabalova, A. B. Salmina, Y. Yamamoto, H. Okamoto, S. Shuto, H. Higashida
- Journal Title
  
  Pharmacol. Res. Perspect.
  
  Volume: 5 Issue: 1 Pages: 1-14
- DOI
  10.1002/prp2.290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Discovery of Novel Indazole Derivatives as Orally Available β3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effect.2017
- Author(s)
  Y. Wada, S. Nakano, A. Morimoto, K. Kasahara, T. Hayash, Y. Takada, H. Suzuki, M. NIwa-Sakai, S. Ohashi, M. Mori, T. Hirokawa, S. Shuto
- Journal Title
  
  J. Med. Chem.
  
  Volume: 60 Issue: 8 Pages: 3252-3265
- DOI
  10.1021/acs.jmedchem.6b01197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] M. Minami, Resolvin E1 and E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR232017
- Author(s)
  K. Deyama, Y. Shimoda, K. Ishikawa, H. Ishimura, H. Fukuda, S. Ide, M. Satoh, S. Shuto
- Journal Title
  
  Psychopharmacology
  
  Volume: 235 Issue: 1 Pages: 329-336
- DOI
  10.1007/s00213-017-4774-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-15K06765, KAKENHI-PROJECT-15K08670
[Journal Article] Discovery of Novel Seven-Membered Prostacyclin Analogs as Potent and Selective Prostaglandin FP and EP3 Dual Agonists.2017
- Author(s)
  I. Sugimoto, T. Kambe, T. Okino, T. Obitsu, N. Ohta, T. Nishiyama, A. Kinoshita, T. Fujimoto, H. Egashira, S.Yamane, S. Shuto, K.Tani, T. Maruyama
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 8 Issue: 1 Pages: 107-112
- DOI
  10.1021/acsmedchemlett.6b00415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Cyclopropane-Based Peptidomimetics Mimicking Wide-Ranging Secondary Structures of Peptides: Conformational Analysis and Their Use in Rational Ligand Optimization.2017
- Author(s)
  A. Mizuno, T. Kameda, T. Kuwahara, H. Endoh, Y. Ito, S. Yamada, K. Hasegawa, A. Yamano, M. Watanabe, M. Arisawa, S. Shuto
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 23 Issue: 13 Pages: 3159-3168
- DOI
  10.1002/chem.201605312
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-17K15476, KAKENHI-PROJECT-16H05106, KAKENHI-PUBLICLY-16H01026
[Journal Article] From Peptides to Peptidomimetics: A Strategy Based on the Structural Features of Cyclopropane2017
- Author(s)
  Mizuno Akira、Matsui Kouhei、Shuto Satoshi
- Journal Title
  
  Chemistry - A European Journal
  
  Volume: 23 Issue: 58 Pages: 14394-14409
- DOI
  10.1002/chem.201702119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05106, KAKENHI-PROJECT-15H02495
[Journal Article] Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction2016
- Author(s)
  Hayato Fukuda, Saki Ito, Kenji Watari, Chihiro Mogi, Mitsuhiro Arisawa, Fumikazu Okajima, Hitoshi Kurose, Satoshi Shuto
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 7 Issue: 5 Pages: 493-497
- DOI
  10.1021/acsmedchemlett.6b00014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-13J03105, KAKENHI-PROJECT-26288051, KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-25253011, KAKENHI-PROJECT-15H04641, KAKENHI-PROJECT-16K15136
[Journal Article] Design, Synthesis, and Identification of 4α-azidoethyl-Cyclic ADP-Carbocyclic-Ribose as a Highly Potent Analogue of Cyclic ADP-Ribose a Ca2+-mobilizing Second Messenger2016
- Author(s)
  Sato, T.; Watanabe, M.; Tsuzuki, T.; Takano, S.; Murayama, T.; Sakurai, T.; Kameda, T.; Arisawa, M.; Fukuda, H.; Shuto, S.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 59 Issue: 15 Pages: 7282-7286
- DOI
  10.1021/acs.jmedchem.6b00437
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-16K15136
[Journal Article] Novel Characteristics of Guanosine 5’-monophosphate 1 Reductase in Pathogenic2 Protozoa Trypanosoma brucei Distinct from Host Animal.2016
- Author(s)
  T. Bessho, T. Okada, C. Kimura, T. Shinohara, A. Tomiyama, A. Imamura, M. Kuwamura, K. Nishimura, K. Fujimori, .S. Shuto, O. Ishibashi, B. K. Kubata, T. Inui
- Journal Title
  
  PLoS Negl. Trop. Dis
  
  Volume: 10 Issue: 1 Pages: e0004339-e0004339
- DOI
  10.1371/journal.pntd.0004339
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-25242046, KAKENHI-PROJECT-25660231, KAKENHI-PROJECT-16K15136
[Journal Article] Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout.2016
- Author(s)
  K. Tatani, M. Hiratochi, N. Kikuchi, Y. Kuramochi, S. Watanabe, Y. Yamauchi, M. Isaji, S, Shuto
- Journal Title
  
  J. Med. Chem
  
  Volume: 59 Issue: 8 Pages: 3719-3731
- DOI
  10.1021/acs.jmedchem.5b01884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-16K15136
[Journal Article] Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents2016
- Author(s)
  Fukuda, H; Muromoto, R.; Takakura, Y.; Ishimura, K.; Kanada, R.; Fushihara, D.; Tanabe, M.; Matsubara, K.; Hirao, T.; Hirashima, K.; Abe, Arisawa, M.; Matsuda, T.; Shuto, S.
- Journal Title
  
  Org. Lett.
  
  Volume: 18 Issue: 24 Pages: 6224-6227
- DOI
  10.1021/acs.orglett.6b02612
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-15K12751, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15K18898, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-16K15136
[Journal Article] Self-assembled Multi-layer Stabilized Nickel Nanoparticle Catalyst for Ligand-free Cross-coupling Reactions: in situ Metal Nanoparticle and Nanospace Simultaneous Organization2016
- Author(s)
  Naoyuki Hoshiya, Katsumasa Fujiki, Takahisa Taniguchi, Tetsuo Honma, Yusuke Tamenori, Mincen Xiao, Nozomi Saito, Mami Yokoyama, Akira Ishii, Hiromichi Fujioka, Satoshi Shuto, Yoshihiro Sato, Mitsuhiro Arisawa
- Journal Title
  
  Adv. Synth. Catal.
  
  Volume: 358 Issue: 15 Pages: 2449-2459
- DOI
  10.1002/adsc.201600024
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H04632, KAKENHI-PROJECT-26288051, KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26460002, KAKENHI-PROJECT-15K12184, KAKENHI-PLANNED-25108003, KAKENHI-PROJECT-16H02950
[Journal Article] Development of a Sulfur-Modified Glass-Supported Pd Nanoparticle Catalyst for Suzuki–Miyaura Coupling2016
- Author(s)
  Mincen Xiao, Naoyuki Hoshiya, Katsumasa Fujiki, Tetsuo Honma, Yusuke Tamenori, Satoshi Shuto, Hiromichi Fujioka, Mitsuhiro Arisawa
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 64 Issue: 8 Pages: 1154-1160
- DOI
  10.1248/cpb.c16-00261
- NAID
  130005253911
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-16K15136
[Journal Article] Pd(II)-Catalyzed Alkylation of Tertiary Carbon via Directing Group-Mediated C(sp3)-H Activation: Synthesis of Chiral 1,1,2-Trialkylsubstituted Cyclopropane.2016
- Author(s)
  N. Hoshiya, K. Takenaka, S. Shuto, J. Uenishi
- Journal Title
  
  Org. Lett
  
  Volume: 18 Issue: 1 Pages: 48-51
- DOI
  10.1021/acs.orglett.5b03229
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26860003
[Journal Article] Highly Sensitive Measurement of Inositol 1,4,5-Trisphosphate by Using a New Fluorescent Ligand and Ligand Binding Domain Combination2016
- Author(s)
  Oura, T.; Murata, K.; Morita, T.; Nezu, A.; Arisawa, M.; Shuto, S.; Tanimura, A.
- Journal Title
  
  ChemBioChem
  
  Volume: 17 Issue: 16 Pages: 1509-1512
- DOI
  10.1002/cbic.201600096
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-26462820, KAKENHI-PROJECT-26462821, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-16K11484, KAKENHI-PROJECT-16K15136, KAKENHI-PUBLICLY-16H01433
[Journal Article] Non-metathesis Heterocycle Formation by Ruthenium-Catalyzed Intramolecular [2+2] Cycloaddition of Allenamide-enes to Azabicyclo[3.1.1]heptanes2016
- Author(s)
  Tomomi Nada, Yusuke Yoneshige, Yasuhiro Ii, Takashi Matsumoto, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa
- Journal Title
  
  ACS Catalysis
  
  Volume: 6 Issue: 5 Pages: 3168-3171
- DOI
  10.1021/acscatal.6b00628
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-15H04632, KAKENHI-PROJECT-26288051, KAKENHI-PUBLICLY-16H01026
[Journal Article] Identification of 8-Aminoadenosine Derivatives as a New Class of Human Concentrative Nucleoside Transporter 2 Inhibitors.2015
- Author(s)
  K. Tatani, M. Hiratochi, Y. Nonaka, M. Isaji, S. Shuto
- Journal Title
  
  ACS Med. Chem. Lett
  
  Volume: 6 Issue: 3 Pages: 244-248
- DOI
  10.1021/ml500343r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-15H02495
[Journal Article] Double Carbonylation of Aryl Iodides with Amines under an Atmospheric Pressure of Carbon Monoxide Using Sulfur- Modified Au-Supported Palladium2015
- Author(s)
  Nozomi Saito Takahisa Taniguchi, Naoyuki Hoshiya, Satoshi Shuto, Mitsuhiro Arisawa, Yoshihiro Sato
- Journal Title
  
  Green Chem.
  
  Volume: 17 Issue: 4 Pages: 2358-2361
- DOI
  10.1039/c4gc02469a
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PUBLICLY-25105701, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-26460002, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26293001
[Journal Article] One-pot Olefin Isomerization/ Aliphatic Enamine Ring-closing Metathesis/ Oxidation/ 1,3-Dipolar Cycloaddition for the Synthesis of Isoindolo[1,2-a]isoquinolines2015
- Author(s)
  Yuki Fujii, Tsunayoshi Takehara, Takeyuki Suzuki, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa
- Journal Title
  
  Adv. Synth. Catal.
  
  Volume: 357 Issue: 18 Pages: 4055-4062
- DOI
  10.1002/adsc.201500680
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-15H04632, KAKENHI-PROJECT-26288051
[Journal Article] Safe Removal of the Allyl Protecting Groups of Allyl Esters using a Recyclable, Low-leaching and Ligand-free Palladium Nanoparticle Catalyst2015
- Author(s)
  Koji Takagi, Hayato Fukuda, Satoshi Shuto, Akira Otaka, Mitsuhiro Arisawa
- Journal Title
  
  Adv. Synth. Catal.
  
  Volume: 357 Issue: 9 Pages: 2119-2124
- DOI
  10.1002/adsc.201500055
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051
[Journal Article] Synthesis of 7-Deaza-cyclic Adenosine-5′-diphosphate-carbocyclic-ribose and Its 7-Bromo Derivative as Intracellular Ca2+-Mobilizing Agents2015
- Author(s)
  Satoshi Takano, Takayoshi Tsuzuki, Takashi Murayama, Takashi Sakurai, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto
- Journal Title
  
  J. Org. Chem.
  
  Volume: 80 Issue: 13 Pages: 6619-6627
- DOI
  10.1021/acs.joc.5b00723
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051
[Journal Article] Lipo-oxytocin-1, A Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-lasting Effects on Anxiety-related Behavior and Social Avoidance in CD157 Knockout Mice.2015
- Author(s)
  A. Mizuno, S. M. Cherepanov, Y. Kikuchi, A. Fakhrul, S. Akther, K. Deguchi, T. Yoshihara, K. Ishihara, S. Shuto , H. Higashida
- Journal Title
  
  Brain Sci
  
  Volume: 5 Issue: 1 Pages: 3-13
- DOI
  10.3390/brainsci5010003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-26460499, KAKENHI-PROJECT-15H02495
[Journal Article] Construction of a chiral quaternary carbon center by a radical cyclization/ring-enlargement reaction: synthesis of 4α-azidoethyl carbocyclic ribose, a key unit for the synthesis of cyclic ADP- ribose derivatives of biological importance2015
- Author(s)
  Takatoshi Sato, Takayoshi Tsuzuki, Satoshi Takano, Kohtaro Kato, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Issue: 33 Pages: 5407-5413
- DOI
  10.1016/j.tet.2015.05.084
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051
[Journal Article] Rolling Circle Translation of Circular RNA in Living Human Cells.2015
- Author(s)
  N. Abe, K. Matsumoto, M. Nishihara, Y. Nakano, A. Shibata, H. Maruyama, S. Shuto, A. Matsuda, M. Yoshida, Y. Ito, H. Abe
- Journal Title
  
  Scientific Rep
  
  Volume: 15 Issue: 1 Pages: 16435-16435
- DOI
  10.1038/srep16435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-25282240
[Journal Article] Nickel-Catalyzed Suzuki-Miyaura Coupling of a Tertiary Iodocyclopropane with Wide Boronic Acid Substrate Scope: Coupling Reaction Outcome Depends on Radical Species Stability2015
- Author(s)
  Keisuke Yotsuji, Naoyuki Hoshiya, Takaaki Kobayashi, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa and Satoshi Shuto
- Journal Title
  
  Adv. Synth. Catal.
  
  Volume: 357 Issue: 5 Pages: 1022-1028
- DOI
  10.1002/adsc.201401000
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25282240, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-26860003, KAKENHI-PROJECT-15H02495
[Journal Article] Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS.2015
- Author(s)
  A. Sasaki, H. Fukuda, N. Shiida, N. Tanaka, A. Furugen, J. Ogura, S. Shuto, N. Mano, H. Yamaguchi
- Journal Title
  
  Anal. Bioanal. Chem
  
  Volume: 407 Issue: 6 Pages: 1625-1639
- DOI
  10.1007/s00216-014-8412-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-25460184, KAKENHI-PROJECT-15H02495
[Journal Article] Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human β3-Adrenergic Receptor Agonists without Cardiovascular Side Effects.2015
- Author(s)
  Y. Wada, H. Shirahashi, T. Iwanami, M. Ogawa, S. Nakano, A. Morimoto, K. Kasahara, E. Tanaka, Y. Takada, S. Ohashi, M. Mori, S. Shuto
- Journal Title
  
  J. Med. Chem
  
  Volume: 58 Issue: 15 Pages: 6048-6057
- DOI
  10.1021/acs.jmedchem.5b00638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Rational hopping of a peptidic scaffold into non-peptidic scaffolds: structurally novel potent proteasome inhibitors derived from a natural product, belactosin A.2014
- Author(s)
  S. Kawamura, Y. Unno, T. Hirokawa, A. Asai, M. Arisawa, S. Shuto
- Journal Title
  
  Chem. Commun
  
  Volume: 50 Issue: 19 Pages: 2445-2447
- DOI
  10.1039/c3cc48818g
- NAID
  120005525210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-25750048
[Journal Article] Structurally novel highly potent proteasome inhibitors created by the dtructure-nased hybridization of non-peptidic belactosin derivatives and peptide boronates.2014
- Author(s)
  S. Kawamura, Y. Unno, A. Asai, M. Arisawa, S. Shuto
- Journal Title
  
  J. Med. Chem
  
  Volume: 57 Issue: 6 Pages: 2726-2735
- DOI
  10.1021/jm500045x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-25750048
[Journal Article] Ligandーfree Suzuki-Miyaura Coupling with Sulfur-modified Gold-supported Palladium in the Synthesis of a Conformationally-Restricted Cyclopropane Compound Library with Three-Dimensional Diversity2014
- Author(s)
  Mitsuhiro ARISAWA
- Journal Title
  
  ACS Combi. Sci.
  
  Volume: 16 Issue: 5 Pages: 215-220
- DOI
  10.1021/co4001138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-26288051
[Journal Article] Development of a New Class of Proteasome Inhibitors with an Epoxyketone Warhead: Rational Hybridization of Non-peptidic Belactosin Derivatives and Peptide Epoxyketones2014
- Author(s)
  Shuhei Kawamura, Yuka Unno, Akira Asai, Mitsuhiro Arisawa, Satoshi Shuto
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Issue: 12 Pages: 3091-3095
- DOI
  10.1016/j.bmc.2014.04.032
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-25750048, KAKENHI-PROJECT-26288051
[Journal Article] Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor2014
- Author(s)
  Takaaki Kobayashi, Akihiro Suemasa, Arisa Igawa, Soichiro Ide, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa, Masabumi Minami, Satoshi Shuto
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 5 Issue: 8 Pages: 889-893
- DOI
  10.1021/ml500134k
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-26288051
[Journal Article] Synthesis of 3',4'-difluoro-3'-deoxyribonucleosides and its evaluation of the biological activities: Discovery of a novel type of anti-HCV agent 3',4'-difluorocordycepin2014
- Author(s)
  Shimada H, Haraguchi K, Hotta K, Miyaike T, Kitagawa Y, Tanaka H, Kaneda R, Abe H, Shuto S, Mori K, Ueda Y, Kato N, Snoeck R, Andrei G, Balzarini J.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Issue: 21 Pages: 6174-82
- DOI
  10.1016/j.bmc.2014.08.024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J02962, KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-25282240, KAKENHI-PROJECT-25293110
[Journal Article] Investigation of the Non-Covalent Binding Mode of Covalent Proteasome Inhibitors around the Transition State by Combined Use of Cyclopropylic Strain-Based Conformational Restriction and Computational Modeling2013
- Author(s)
  Shuhei KAWAMURA
- Journal Title
  
  J. Med. Chem.
  
  Volume: 56 Issue: 14 Pages: 5829-5842
- DOI
  10.1021/jm400542h
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-25750048, KAKENHI-PROJECT-26288051
[Journal Article] Three-Dimensional Structural Diversity-Oriented Peptidomimetics Based on the Cyclopropylic Strain2013
- Author(s)
  Akira Mizuno
- Journal Title
  
  Org. Lett.
  
  Volume: 15 Issue: 7 Pages: 1686-1689
- DOI
  10.1021/ol400469w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-24710260, KAKENHI-PUBLICLY-25105702, KAKENHI-PUBLICLY-23105502
[Journal Article] Design and synthesis of the stabilized analogs of belactosin A with the unnatural cis-cyclopropane structure2013
- Author(s)
  Shuhei KAWAMURA
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 11 Issue: 38 Pages: 6615-6622
- DOI
  10.1039/c3ob41338a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-25750048
[Journal Article] Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)-H Bond Activation to Construct Quaternary Carbon. Centers : Synthesis of cis- and trans-1,1,2-Trisubstituted Chira1 Cyclopropanes2013
- Author(s)
  N. Hoshiya, M. Arisawa, S. Shuto
- Journal Title
  
  Organic Letters
  
  Volume: 15 Issue: 24 Pages: 6202-6205
- DOI
  10.1021/ol4030452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J03163, KAKENHI-PROJECT-24390023
[Journal Article] Conformational Restriction Approach to BACE1 InhibitorsII:SAR Study of the Isocytosine Derivatives Fixed with a cis-Cyclopropane Ring.2013
- Author(s)
  Shuji YONEZAWA
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 23 Issue: 10 Pages: 2912-2915
- DOI
  10.1016/j.bmcl.2013.03.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PUBLICLY-23105502
[Journal Article] Potent Proteasome Inhibitors Derived from the Unnatural Cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action.2013
- Author(s)
  Shuhei KAWAMURA
- Journal Title
  
  J. Med. Chem.
  
  Volume: 56 Issue: 9 Pages: 3689-3700
- DOI
  10.1021/jm4002296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-25750048, KAKENHI-PUBLICLY-23105502
[Journal Article] Cyclopropane-Based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports2013
- Author(s)
  K. Nakada, M. Yoshikawa, S. Ide, A. Suemasa, S. Kawamura, T. Kobayashi, E. Masuda, Y. Ito, W. Hayakawa, T. Katayama, S. Yamada, M. Arisawa, M. Minami, S. Shuto
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 21 Issue: 17 Pages: 4938-4950
- DOI
  10.1016/j.bmc.2013.06.063
- NAID
  120005358936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023
[Journal Article] Preparation of nonracemic bromomethylenecyclopropane and its use in Suzuki-Miyaura coupling; synthesis of the arylmethyl-cis-cyclopropane structure core.2013
- Author(s)
  Makoto TANABE
- Journal Title
  
  J. Org. Chem.
  
  Volume: 78 Issue: 23 Pages: 11714-11720
- DOI
  10.1021/jo401675z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-24710260, KAKENHI-PUBLICLY-25105702
[Journal Article] Conformational restriction approach to β-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations2013
- Author(s)
  S. Yonezawa, K Fujiwara, T. Yamamoto, K. Hattori, H. Yamakawa, C. Muto, M. Hosono, Y. Tanaka, T. Nakano, H. Takemoto, M. Arisawa, S. Shuto
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 21 Issue: 21 Pages: 6506-6522
- DOI
  10.1016/j.bmc.2013.08.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023
[Journal Article] Cyclopropane-Based Stereochemical Diversity-Oriented Conformational Restriction Strategy : Histamine Analog swith the4-Amino-2, 3-methano-1-(1H-imidazol-4-yl) butane Structure as Highly PotentHistamine H_3 and/or H4 Receptor Ligands. Org2012
- Author(s)
  M. Watanabe, T. Kobayashi, T. Hirokawa, A. Yoshida, Y. Ito, S. Yamada, N. Orimoto, Y. Yamasaki, M. Arisawa, S. Shuto
- Journal Title
  
  Biomol. Chem
  
  Volume: 10 Issue: 4 Pages: 736-745
- DOI
  10.1039/c1ob06496g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028, KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-23659049, KAKENHI-PUBLICLY-23105502
[Journal Article] Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors.2012
- Author(s)
  H. Miyakoshi, S. Miyahara, T. Yokogawa, K. T. Chong, J. Taguchi, K. Endoh, W. Yano, T. Wakasa, H. Ueno, Y. Takao, M. Nomura, S. Shuto, H. Nagasawa, M. Fukuoka
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Issue: 7 Pages: 2960-2969
- DOI
  10.1021/jm201627n
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023
[Journal Article] Cyclopropane-Based Stereochemical Diversity-Oriented Conformational Restriction Strategy : Histamine Analogs with the 4-Amino-2,3-methano-1-(1H-imidazol-4-y1) butane Structure as Highly Potent Histamine H3 and/or H4 Receptor Ligands2012
- Author(s)
  M.Watanabe, T.Kobayashi, T.Hirokawa, A.Yoshida, Y.Ito, S.Yamada, N.Orimoto, Y.Yamasaki, M.Arisawa, S.Shuto
- Journal Title
  
  Org.Biomol.Chem
  
  Volume: 10 Pages: 736-745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] 1,2,3-Triazole-Containing Uracil Derivatives with Excellent Pharmacokinetics as a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors.2012
- Author(s)
  H. Miyakoshi, S. Miyahara, K. Endoh, J. Taguchi, M. Nomura, Y. Takao, A. Fujioka, A. Hashimoto, K Itou, K. Yamamura, S. Shuto, H. Nagasawa, M. Fukuoka
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Issue: 14 Pages: 6427-6437
- DOI
  10.1021/jm3004174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023
[Journal Article] Discovery of Highly Potent Human Deoxyuridine Triphosphatase Inhibitors Based on the Conformation Restriction Strategy.2012
- Author(s)
  S. Miyahara, H. Miyakoshi, T. Yokogawa, T. Muto, K. Endoh, W. Yano, T. Wakasa, H. Ueno, K. Itou, M. Nomura, H. Nagasawa, S. Shuto
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55, Issue: 11 Pages: 5483-5496
- DOI
  10.1021/jm300416h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023
[Journal Article] Cyclopropane-Based Stereochemical Diversity-Oriented Conformational Restriction Strategy : Histamine Analogs with the 4-Amino-2, 3-methano-1-(1H-imidazol-4-yl)butane Structure as Highly Potent Histamine H3 and/or H4 Receptor Ligands.2012
- Author(s)
  M. Watanabe, T. Kobayashi, T. Hirokawa, A. Yoshida, Y. Ito, S. Yamada, N. Orimoto, Y. Yamasaki, M. Arisawa, S. Shuto
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 10 Pages: 736-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023
[Journal Article] A Conformational Restriction Approach to β-secretase (BACE1) Inhibitors: Effect of a Cyclopropane Ring to Induce an Alternative Binding Mode2012
- Author(s)
  Shuji Yonezawa
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Issue: 20 Pages: 8838-8858
- DOI
  10.1021/jm3011405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-23659049, KAKENHI-PUBLICLY-23105502
[Journal Article] Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors2012
- Author(s)
  S.Miyahara, H.Miyakoshi, T.Yokogawa, K.T.Chong, J.Taguchi, T.Muto, K.Endoh, W.Yano, T.Wakasa, H.Ueno, Y.Takao, A.Fujioka, A.Hashimoto, K.Itou, K.Yamamura, M.Nomura, H.Nagasawa, S.Shuto, M.Fukuoka
- Journal Title
  
  J.Med.Chem.
  
  Volume: 55 Pages: 2970-2980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Design and Synthesis of Indomethacin Analogues That Inhibit P-Glycoprotein and/or Multidrug Resistant Protein without Cox Inhibitory Activity2012
- Author(s)
  Mitsuhiro Arisawa, Yayoi Kasaya, Tohru Obata, Takuma Sasaki, Tomonori Nakamura, Takuya Araki, Koujirou Yamamoto, Akito Sasaki, Akihito Yamano, Mika Ito, Hiroshi Abe, Yoshihiro Ito, and Satoshi Shuto
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 55 Issue: 18 Pages: 8152-8163
- DOI
  10.1021/jm301084z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06507, KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-23105502
[Journal Article] Ruthenium-catalyzed cycloisomerization of 1,3-dienes, for example, an N-dienyl-2-vinylaniline derivative, leading to a 3-Exomethylene-2-vinylindole derivative and its application to the synthesis of (±)-cinchonaminone2012
- Author(s)
  Takao Ogawa
- Journal Title
  
  Eur. J. Org. Chem.
  
  Volume: - Issue: 16 Pages: 3084-3087
- DOI
  10.1002/ejoc.201200260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-23105502
[Journal Article] Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors.2012
- Author(s)
  S. Miyahara, H. Miyakoshi, T. Yokogawa, K. T. Chong, W. Yano, T. Wakasa, H. Ueno, Y. Takao, A. Fujioka, A. Hashimoto, K. Itou, K. Yamamura, M. Nomura, H. Nagasawa, S. Shuto, M. Fukuoka
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Issue: 7 Pages: 2970-2980
- DOI
  10.1021/jm201628y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023
[Journal Article] Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors2012
- Author(s)
  H.Miyakoshi, S.Miyahara, T.Yokogawa, K.T.Chong, J.Taguchi, K.Endoh, W.Yano, T.Wakasa, H.Ueno, Y.Takao, M.Nomura, S.Shuto, H.Nagasawa, M.Fukuoka
- Journal Title
  
  J.Med.Chem.
  
  Volume: 55 Pages: 2960-2969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] One-pot ring-closing metathesis(RCM)/oxidation by an assisted tandem rutheniumcatalysis for the synthesis of 2-quinolones.2012
- Author(s)
  H. Kato, T. Ishigame, N. Oshima, K. Shimawaki, M. Arisawa, S. Shuto
- Journal Title
  
  Adv. Synth. Cat.
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Ligand-Free Buchwald-Hartwig Aromatic Aminations of Aryl Halides Catalyzed by Low-Leaching and Highly Recyclable Sulfur-Modified Gold-Supported Palladium Material2012
- Author(s)
  Mohammad Al-Amin, Tetsuo Honma, Naoyuki Hoshiya, Takatoshi Sato, Satoshi Shuto, Mitsuhiro Arisawa
- Journal Title
  
  Adv.Synth.Catal.
  
  Volume: 354 Issue: 6 Pages: 1061-1068
- DOI
  10.1002/adsc.201100761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J03163, KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-23105502
[Journal Article] Conformational Restriction Approach to y -Secretase (BACE1)Inhibitors : Effect of a Cyclopropane Ring To Induce an Alternative Binding Mode.2012
- Author(s)
  S. Yonezawa, T. Yamamoto, H. Yamakawa, C. Muto, M. Hosono, K. Hattori, K. Higashino, T. Yutsudo, H. Iwamoto, Y. Kondo, M. Sakagami, H. Togame, Y. Tanaka, T. Nakano, H. Takemoto, M. Arisawa, S. Shuto,
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Issue: 6 Pages: 8838-8858
- DOI
  10.2174/156802606776743084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023
[Journal Article] Characterization of new potential anti-cancer drugs designed to overcome glutathione transferase mediated resistance.2011
- Author(s)
  K. Johansson, M. Ito, C. M. S. Schophuizen, S. Mathew, V. Heuser, J. Zhang, M. Shimoji, M. E. Vahter, W. H. Ang, P. J. Dyson, A. Shibata, S. Shuto, Y. Ito, H. Abe, R. Morgenstern
- Journal Title
  
  Mol. Pharmaceut.
  
  Volume: 8 Pages: 1698-1708
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy2011
- Author(s)
  J.Zhang, A.Shibata, M.Ito, S.Shuto, Y.Ito, B.Mannervik, H.Abe. R.Morgenstern
- Journal Title
  
  J.Am.Chem.Soc
  
  Volume: 133 Pages: 14109-14119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Alkene isomerization/enamide-ene and diene metathesis for the construction of indoles, quinolines, benzofurans and chromenes with a chiral cyclopropane substituent2011
- Author(s)
  Kobayashi, T., Arisawa, M., Shuto, S.
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 9 Issue: 4 Pages: 1219-1224
- DOI
  10.1039/c0ob00597e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J07038, KAKENHI-PROJECT-21390028, KAKENHI-PROJECT-23246013
[Journal Article] Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy.2011
- Author(s)
  J. Zhang, A. Shibata, M. Ito, S. Shuto, Y. Ito, B. Mannervik, H. Abe. R. Morgenstern
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 133 Pages: 14109-14119
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Design and synthesis of conformationally restricted indomethacin analogues that enhance doxorubicin cytotoxicity in multidrug resistant cells without cyclooxygenase inhibitory activity2011
- Author(s)
  M.Arisawa, Y.Kasaya, T.Obata, T.Sasaki, M.Ito, H.Abe, Y.Ito, A.Yamano, S.Shuto
- Journal Title
  
  ACS Med.Chem.Lett
  
  Volume: 2 Pages: 353-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Alkene isomerization/enamide-ene and diene metathesis for the construction of indoles, quinolines, benzofurans and chromenes with a chiral cyclopropane substituent.2011
- Author(s)
  T. Kobayashi, M. Arisawa, S. Shuto
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 9 Pages: 1219-1224
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine.2011
- Author(s)
  M. Watanabe, K. Yamaguchi, W. Tang, K. Yoshida, R. B. Silverman, M. Arisawa, S. Shuto
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 19 Pages: 5984-5988
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Alkene isomerization/enamide-ene and diene metathesis for the construction of indoles, quinolines, benzofurans and chromenes with a chiral cyclopropane substituent2011
- Author(s)
  T.Kobayashi, M.Arisawa, S.Shuto
- Journal Title
  
  Org.Biomol.Chem
  
  Volume: 9 Pages: 1219-1224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] One-pot ring-closing metathesis(RCM)/oxidation by an assisted tandem rutheniumcatalysis for the synthesis of 2-quinolones2011
- Author(s)
  H.Kato, T.Ishigame, N.Oshima, K.Shimawaki, M.Arisawa, S.Shuto
- Journal Title
  
  Adv.Synth.Cat
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Synthesis of a series of 3,4-methanoarginines as side-chainconformationally restricted analogues of arginine2011
- Author(s)
  M. Watanabe, K. Yamaguchi, W. Tang, K. Yoshida, R. B. Silverman, M. Arisawa, S. Shuto
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 19 Pages: 5984-5988
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21917467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Characterization of new potential anti-cancer drugs designed to overcome glutathione transferase mediated resistance2011
- Author(s)
  K.Johansson, M.Ito, C.M.S.Schophuizen, S.Mathew, V.Heuser, J.Zhang, M.Shimoji, M.E.Vahter, W.H.Ang, P.J.Dyson, A.Shibate, S.Shuto, Y.Ito, H.Abe, R.Morgenstern
- Journal Title
  
  Mol.Pharmaceut
  
  Volume: 8 Pages: 1698-1708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Design and synthesis of conformationally restricted indomethacin analogues that enhance doxorubicin cytotoxicity in multidrug resistant cells without cyclooxygenase inhibitory activity.2011
- Author(s)
  M. Arisawa, Y. Kasaya, T. Obata, T. Sasaki, M. Ito, H. Abe, Y. Ito, A. Yamano, S. Shuto
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 2 Pages: 353-357
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine2011
- Author(s)
  M.Watanabe, K.Yamaguchi, W.Tang, K.Yoshida, R.B.Silverman, M.Arisawa, S.Shuto
- Journal Title
  
  Bioorg.Med.Chem
  
  Volume: 19 Pages: 5984-5988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Synthesis and Structural and Pharmacological Properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H_3/H_4 receptor ligands. Bioorg2010
- Author(s)
  T. Kobayashi, M. Watanabe, A. Yoshida, S. Yamada, M. Ito, H. Abe, Y. Ito, M. Arisawa, S. Shuto
- Journal Title
  
  Med. Chem
  
  Volume: 18 Pages: 1076-1082
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/20045649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Investigation of the Bioactive Conformation of Histamine H_3 ReceptorAntagonists by the Cyclopropylic Strain-Based Conformational Restriction Strategy2010
- Author(s)
  M. Watanabe, T. Hirokawa, T. Kobayashi, A. Yoshida, Y. Ito, S. Yamada, N. Orimoto, Y. Yamasaki, M. Arisawa, S. Shuto
- Journal Title
  
  J. Med. Chem
  
  Volume: 53 Issue: 9 Pages: 3585-3593
- DOI
  10.1021/jm901848b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Three-dimensional structure-activity relationship study of belactosin A and its stereo and regioisomers : development of potent proteasome inhibitors by the stereochemical diversity-oriented strategy. Org2009
- Author(s)
  K. Yoshida, K. Yamaguchi, A. Mizuno, Y. Unno, A. Asai, T. Sone, H. Yokosawa, A. Matsuda, M. Arisawa, S. Shuto
- Journal Title
  
  Biomol. Chem
  
  Volume: 7 Pages: 1868-1877
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/19590782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] ピラノースの配座制御に基づく立体選択的グリコシル化反応2008
- Author(s)
  周東智, 他
- Journal Title
  
  有機合成化学 66
  
  Pages: 50-60
- NAID
  10020127690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390027
[Journal Article] . Design, synthesis, and biological activity of carbocyclic analogues of cyclic ADP-ribose, a Ca^2+-mobilizing second messenger.2007
- Author(s)
  S. Shuto
- Journal Title
  
  Nucleic Acids Symposium Series 51
  
  Pages: 109-110
- Data Source
  KAKENHI-PROJECT-17390027
[Journal Article] 創薬化学からミゾリビンを考える:ミゾリビンリン酸はIMPDHの遷移状態模倣型阻害剤である2007
- Author(s)
  周東智
- Journal Title
  
  炎症と免疫 15
  
  Pages: 135-141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390027
[Journal Article] Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl) thymidines.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Nucleic Acids Res. Supplement 48
  
  Pages: 67-68
- Data Source
  KAKENHI-PROJECT-15590096
[Journal Article] Chemistry of cyclic ADP-ribose and its analogs.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Curr.Med.Chem. 11
  
  Pages: 827-845
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590096
[Journal Article] Chemistry of cyclic ADP-ribose and its analogs.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Curr.Med.Chem. 11
  
  Pages: 827-845
- Data Source
  KAKENHI-PROJECT-16023205
[Journal Article] Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Nucleic Acids Res.Supplement. 48
  
  Pages: 67-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590096
[Journal Article] Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl) thymidines.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Nucleic Acids Res.Supplement. 48
  
  Pages: 67-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590096
[Journal Article] Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl) thymidines.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Nucleic Acids Res.Supplement. 48
  
  Pages: 67-68
- Data Source
  KAKENHI-PROJECT-16023205
[Journal Article] Design and Synthesis of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose, a Ca-Mobilizing Second Messenger
- Author(s)
  T. Tsuzuki, N. Sakaguchi, T. Kudoh, S. Takano, M. Uehara, T. Murayama, T. Sakurai, M. Hashii, H. Higashida, K. Weber, A. H. Guse, T. Kameda, T. Hirokawa, Y. Kumaki, B. V. L. Potter,H. Fukuda, M. Arisawa, S. Shuto
- Journal Title
  
  Angew.Chem. Int. Ed
  
  Volume: (印刷中)
- Data Source
  KAKENHI-PROJECT-23659049
[Patent] レゾルビンＥ２の安定等価体2020
- Inventor(s)
  周東　智、松田　正、室本竜太、福田　隼
- Industrial Property Rights Holder
  周東　智、松田　正、室本竜太、福田　隼
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H01014
[Patent] プロレニン受容体リガンド及びアンタゴニスト2016
- Inventor(s)
  周東　智、石田　晋、神田敦宏、桑原智希
- Industrial Property Rights Holder
  周東　智、石田　晋、神田敦宏、桑原智希
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-023315
- Filing Date
  2016-02-10
- Data Source
  KAKENHI-PROJECT-15H02495
[Patent] 被検物質測定FRET分子センサー2015
- Inventor(s)
  谷村明彦、周東智、森田貴雄、根津顕弘
- Industrial Property Rights Holder
  谷村明彦、周東智、森田貴雄、根津顕弘
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-096991
- Filing Date
  2015-05-12
- Data Source
  KAKENHI-PROJECT-26670812
[Patent] リン脂質コンジュゲート2015
- Inventor(s)
  周東　智、川村周平、山田静雄、伊藤由彦
- Industrial Property Rights Holder
  周東　智、川村周平、山田静雄、伊藤由彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-044079
- Filing Date
  2015-03-05
- Data Source
  KAKENHI-PROJECT-24390023
[Patent] 環状ペプチドの膜透過性および／または代謝安定性を改善するシクロプロパンアミノ酸ユニット2015
- Inventor(s)
  松井耕平、周東　智
- Industrial Property Rights Holder
  松井耕平、周東　智
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-167408
- Filing Date
  2015-08-27
- Data Source
  KAKENHI-PROJECT-15H02495
[Patent] 新規オキシトシン誘導体およびそれを含む医薬組成物2014
- Inventor(s)
  周東　智、水野　彰、東田陽博
- Industrial Property Rights Holder
  周東　智、水野　彰、東田陽博
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-139048
- Filing Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-24390023
[Patent] 被検物質測定ＦＲＥＴ分子センサー2014
- Inventor(s)
  谷村明彦、周東智、森田貴雄、根津顕弘
- Industrial Property Rights Holder
  谷村明彦、周東智、森田貴雄、根津顕弘
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-099067
- Filing Date
  2014-05-12
- Data Source
  KAKENHI-PROJECT-26670812
[Presentation] VCP化合物による脊髄損傷後血液脊髄関門機能保護作用2022
- Author(s)
  鈴木裕貴、角家健、五月女慧人、遠藤健、船木智、周東智、前仲勝実、岩崎倫政
- Organizer
  第37回日本整形外科学会基礎学術総会
- Data Source
  KAKENHI-PROJECT-20K09449
[Presentation] 抗炎症収束性脂質レゾルビン類をプロトタイプとする創薬化学研究2021
- Author(s)
  藤原広、村上侑斗、池田紘之、福田隼、石原淳、渡邉瑞貴、周東智
- Organizer
  反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] シクロプロパンδ-アミノ酸を基盤とした新規フォルダマーの開発2019
- Author(s)
  永田真, 土井良平, 竹内恒、亀田倫史、藤原広一, 渡邉瑞貴, 周東智
- Organizer
  第52回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] Design and synthesis of selective BGT-1 inhibitors based on the conformational restriction strategy2019
- Author(s)
  三井桂佑,末政亮大,小林嵩明,Petrine Wellendorph,人羅菜津子,南雅文,藤原広一,渡邉瑞貴,周東智
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] スピロシクロプロパン構造を基盤としたαヘリックスミメティクスの創製研究2019
- Author(s)
  坂下遼太郎, 桑原智希, 藤原広一, 渡邉瑞貴, 周東智
- Organizer
  第52回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] Synthesis of Enantiomerically Pure 1,2,3-Trisubstituted Cyclopropane Nucleosides2019
- Author(s)
  酒井仁，福多洸太朗，星谷尚亨，福田隼，渡邉瑞貴，周東智
- Organizer
  27th International Society of Heterocyclic Chemistry Congress
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] DEVELOPMENT OF MEMBRANE PERMEABLE CYCLIC PEPTIDES AS STAT3 DIMERIZATION INHIBITORS: A CONFORMATIONAL RESTRICTION STRATEGY FOR REGURATING PROTEIN-PROTEIN INTERACTIONS2019
- Author(s)
  Takayuki Osada, Kouhei Matsui, Koichi Fujiwara, Katsumi Ota, Akira Asai, Mizuki Watanabe, and Satoshi Shuto
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] DESIGN AND SYNTHESIS OF NOVEL HELICAL FOLDAMERS BASED ON CYCLOPROPANE Δ-AMINO ACIDS2019
- Author(s)
  永田真, 竹内恒、土井良平、亀田倫史、藤原広一, 佐藤美洋, 渡邉瑞貴, 周東智
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] Improvement of Membrane Permeability of Cyclic Peptides By Conformational Restriction Using Cyclopropane2019
- Author(s)
  Mizuki Watanabe,Yukina Sato,Mai Uemura,Nanami Kato,Kouhei Matsui,Yoh Takekuma,Mitsuru Sugawara,Koh Takeuchi,Satoshi Shuto
- Organizer
  23rd Korean Peptide Protein Society Symposium
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] Improvement of Membrane Permeability of Cyclic Peptides By Conformational Restriction Using Cyclopropane2019
- Author(s)
  Mizuki Watanabe, Yukina Sato, Mai Uemura, Nanami Kato, Kouhei Matsui, Yoh Takekuma, Mitsuru Sugawara, Satoshi Shuto
- Organizer
  12th AFMC International Medicinal Chemistry Symposium
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] trans-1, 2-シクロプロパンジアミンおよびジカルボン酸からなるオリゴアミドの合成研究2018
- Author(s)
  山田圭恭, 一ノ瀬亘, 福田隼, 渡邉瑞貴, 周東智
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] シクロプロパンの構造特性に基づく膜透過性環状ペプチドの設計と合成2018
- Author(s)
  植村　真衣, 加藤　七海,松井　耕平, 桑原　智希, 渡邉　瑞貴, 福田　隼, 竹内　恒, 広川　貴次, 武隈　洋, 菅原満, 周東　智
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] GABAトランスポーターサブタイプ選択的阻害剤の創出を目的とするGABA配座制限誘導体の設計と合成2018
- Author(s)
  末政亮大、中田和彰、小林嵩明、福田隼、渡邉瑞貴、井手聡一郎、人羅菜津子、南雅文、周東智
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] 炎症収束性脂質レゾルビンE1配座制限誘導体の設計と合成2017
- Author(s)
  石村航平，福田隼，渡邉瑞貴，周東智
- Organizer
  第15回次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] 光学活性1,2,3-三置換シクロプロパンヌクレオシドの合成2017
- Author(s)
  南貴覚、福多洸太朗、星谷尚亨、福田隼、渡邉瑞貴、周東智
- Organizer
  第29回万有札幌シンポジウム
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] Spiro-cyclopropane type α-helix/β-strand mimimetics targeting protein-protein interactions2017
- Author(s)
  Tomoki Kuwahara, Akira Mizuno, Hayato Fukuda, Mizuki Watanabe, Satoshi Shuto
- Organizer
  254th ACS National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] Rational Development of Cyclopropane-Based Target-Selective Compounds such as GABA Transporter Inhibitors2017
- Author(s)
  周東智
- Organizer
  Drug Research Academy
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] シクロプロパンの立体及び立体電子特性に基づくペプチドミメティクス2017
- Author(s)
  桑原智希，植村真衣，水野彰，一ノ瀬亘，松井耕平，福田隼，渡邉瑞貴，周東智
- Organizer
  第43回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] 新規GABAトランスポーター阻害薬候補化合物の薬理活性評価2016
- Author(s)
  佐藤孝行、井川ありさ、圓山智嘉史、末政亮大、小林嵩明、有澤光弘、井手聡一郎、周東智、南雅文
- Organizer
  日本薬学会薬理系薬学部会　次世代を担う創薬・医療薬理シンポジウム2016
- Place of Presentation
  東北大学（宮城県・仙台市）
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-15K14960
[Presentation] GABAトランスポーターサブタイプ特異的な新規阻害薬候補化合物の薬理活性評価2016
- Author(s)
  佐藤孝行、井川ありさ、圓山智嘉史、末政亮大、小林嵩明、有澤光弘、井手聡一郎、周東智、南雅文
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K14960
[Presentation] Design and Synthesis of Biologically Active Compounds Based on the Structural Features of Cyclopropane2016
- Author(s)
  Satoshi Shuto
- Organizer
  The 8th Takeda Science Foundation Symposium on Pharmasciences. Biomolecule-Based Medicinal Science: Featuring Mid-Size Drugs
- Place of Presentation
  武田薬品工業研究所（大阪府吹田市）
- Year and Date
  2016-01-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] Medicinal chemical study on cyclic ADP‐ribose for developing the stable and potent agonists and antagonists2015
- Author(s)
  Satoshi Shuto
- Organizer
  FASEB Science Research Conference on NAD Metabolism and Signaling
- Place of Presentation
  Timmendorfer Strand, Germany
- Year and Date
  2015-08-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] A novel method for IP3 measurement with fluorescent adenophostin A derivatives2015
- Author(s)
  Tanimura, Akihiko Akihiro Nezu, Takao Morita, Satoshi Shuto
- Organizer
  Gordon Research Conference, Calcium Signalling
- Place of Presentation
  Sunday River Grand Summit Hotel, ME, USA
- Year and Date
  2015-06-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670812
[Presentation] ペプチド性天然物ベラクトシンAをプロトタイプとする高活性非ペプチド性プロテアソーム阻害剤の創製：“Scaffold Hopping”に基づく論理的分子設計と合成2013
- Author(s)
  川村周平（学生最優秀発表賞受賞）、海野雄加、浅井章良、有澤光弘、周東智
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24390023
[Presentation] Ca動員セカンドメッセンジャーの化学 ―細胞内情報伝達系の創薬標的化を目指してー2012
- Author(s)
  周東　智
- Organizer
  産業総合研究所・分子標的創薬セミナー2000.12.6
- Place of Presentation
  産業技術総合研究所生命情報工学研究センター（　東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-23659049
[Presentation] 三次元多様型配座制御法に基づくペプチドミメティックの設計.メラノコルチン受容体リガンドの創製-2011
- Author(s)
  水野彰、三浦志帆、渡辺瑞貴、小田上剛直、小上裕二、有澤光弘、周東智
- Organizer
  第37回反応と合成の進歩シンポジウム
- Place of Presentation
  徳島大学(徳島市)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Stereochemical Diversity-Oriented Design of Cyclopropane-Based Peptidomimetics : Synthesis of Melanocortin Receptor Ligands2011
- Author(s)
  Mizuno, A.; Miura, S.; Watanabe, M.; Uchida, S.; Yamada, S.; Arisawa, M.; Shuto, S.
- Organizer
  28th Herbert C. Brown Lectures
- Place of Presentation
  Purdue University (USA)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] 制がん性プロテアソーム阻害剤ベラクトシンAシス型立体異性体の構造活性相関研究2011
- Author(s)
  川村周平、海野雄加、田中基裕、佐々木磨、浅井章良、有澤光弘、周東智
- Organizer
  第131年会日本薬学会
- Place of Presentation
  グランシップツインメッセ静岡(静岡県)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Design of Stereochemical Diversity-Oriented Cyclopropane-Based Peptidomimetics : Development of Potent Melanocortin Receptor Ligands2011
- Author(s)
  Mizuno, A.; Miura, S.; Watanabe, M.; Uchida, S.; Yamada, S.; Arisawa, M.; Shuto, S.
- Organizer
  Otsu Conference 2011
- Place of Presentation
  大津プリンスホテル(滋賀県)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Structure-Activity Relationship Study of Unnatural cis-Isomer of Belactosin A, a Potent Proteasome Inhibitor2011
- Author(s)
  Shuhei, Kawamura, Yuka, Unno, Motohiro, Tanaka, Takuma, Sasaki, Akira, Asai, Mitsuhiro, Arisawa, and Satoshi, Shuto
- Organizer
  AIMECS 11 8t AFMC International Medicinal Chemistry Symposium Frontier of Medicinal Science
- Place of Presentation
  京王プラザホテル東京(東京都)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Investigation of the bioactive conformation of Histamine H3/H4 receptor antagonists by the conformational restriction strategy2011
- Author(s)
  Kobayashi, T. , Watanabe, M., Hirokawa, T., Yamada, S., Arisawa, M., Shuto, S.
- Organizer
  8th AFMC International Medicinal Chemistry Symposium (AIMECS11)
- Place of Presentation
  京王プラザホテル東京(東京都)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] 光学活性シクロプロパンを有する複素環化合物合成法の開発2010
- Author(s)
  小林嵩明、有澤光弘、周東智
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山県)、岡山大学(岡山市)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Enamide-ene methasesis for constructing chiral 2-cyclopropylheterocycles : Indole, quinoline, benzofuran and chromene2010
- Author(s)
  Kobayashi, T., Arisawa, M., Shuto, S.
- Organizer
  240th American Chemical Society National Meeting
- Place of Presentation
  Boston Convention & Exposition Center (USA)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] 立体多様性を鍵とするシクロプロパン型ペプチドミメティック-メラノコルチン受容体リガンドの創製研究-2009
- Author(s)
  水野彰、梶原浩気、三浦志帆、渡辺瑞貴、吉田徳、内田信也、山田静雄、小田上剛直、小上裕二、有澤光弘、周東智
- Organizer
  第7回次世代を担う有機化学シンポジウム
- Place of Presentation
  大阪大学(吹田市)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] シクロプロパン歪みに基づくヒスタミンH3受容体リガンドの設計と活性配座解析2009
- Author(s)
  小林嵩明、渡辺瑞貴、広川貴次、吉田徳、伊東由彦、山田静雄、有澤光弘、周東智
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京大学(文京区)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Design, synthesis, and biological activity of carbocyclic analogues of cyclic ADP-ribose, a Ca^2÷-mobilizing second messenger.2007
- Author(s)
  周東智
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京(東京大学安田講堂)
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-17390027
[Presentation] Design, synthesis, and biological activity of carbocyclic analogues of cyclic ADP-ribose, a Ca^<2+>-mobilizing second messenger2007
- Author(s)
  周東智
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京(東京大学安田講堂)
- Year and Date
  2007-11-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390027
[Presentation] "Design, synthesis, and biological activity of carbocyclic analogues of cyclic ADP-ribose, a Ca^<2+>-mobilizing second messenger"2007
- Author(s)
  Satoshi Shuto
- Organizer
  5^<th> Internarnational Symposimon Nucleic Acid Chemistry (Tokyo)
- Place of Presentation
  Tokyo University
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390027
[Presentation] Synthesis of 5"-substituted cyclic ADP-carbocyclic ribose as hiologicaltools"2006
- Author(s)
  Natsum Sakaguchi, Takashi Kudoh, Takashi Murayama, Mitsuhiro Arisawa, Satoshi Shuto
- Organizer
  33th Nucleic Acd Symposium (Osaka)
- Place of Presentation
  Osaka University
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390027
[Presentation] Synthesis and biological activity of 4", 6"-unsaturatred cyclic ADP-carbocyclic-ribose2005
- Author(s)
  Takashi Kudoh, Takashi Murayama, Akira Matsuda, Satoshi Shuto
- Organizer
  4^<th> Internarnational Symposium on Nucleic Acid Chemistry (Fuuoka) 2005
- Place of Presentation
  Kyushu University Faculty of Medicine
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390027
[Presentation] Ca動員セカンドメッセンジャーの化学-細胞内情報伝達系の創薬標的化を目指して2000
- Author(s)
  周東智
- Organizer
  産業総合研究所・分子標的創薬セミナー
- Place of Presentation
  産業技術総合研究所生命情報工学研究センター(東京都江東区)
- Year and Date
  2000-12-06
- Data Source
  KAKENHI-PROJECT-23659049
[Presentation] Development of Potent Ligands by the Three-Dimensional Diversity-Oriented Strategy Based on the Characteristic Stereo-and Stereoelectronic Feature of Cyclopopane.
- Author(s)
  Satoshi Shuto
- Organizer
  Frontier in Medicinal Chemistry
- Place of Presentation
  Marburg (Germany)
- Year and Date
  2015-03-15 – 2015-03-18
- Invited
- Data Source
  KAKENHI-PROJECT-24390023
[Presentation] ddntification of the first highly selective BGT-I inhibitor based on conformational restriction of GABA.
- Author(s)
  末政亮大、中田和彰、小林嵩明、井川ありさ、福田隼、阿部洋、有澤光弘、井手聡一郎、南雅文、周東智
- Organizer
  The 12th International Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  札幌
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24390023
[Presentation] ファゴサイトーシス誘導性ホスファチジルセリン二量体類縁化合物の創製研究
- Author(s)
  佐藤耀、川村周平、平尾徹、室元竜太、福田隼、阿部洋、松田正、周東智
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25670048
[Presentation] PdおよびNi触媒によるシクロプロパン第三級炭素上への芳香環導入反応―効率的化学空間探索型創薬ライブラリーの構築を目指して―
- Author(s)
  星谷尚亨、四辻慶佑、小林嵩明、福田　隼、阿部　洋、有澤光弘、周東　智
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24390023
[Presentation] GABA配座制限に基づく初のGABAトランスポーターBGT-1サブタイプ高選択的阻害剤の創製
- Author(s)
  末政亮大、小林嵩明、井川ありさ、福田隼、阿部洋、井手聡一郎、南雅文、周東智
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-24390023
[]
[]
[]

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Shuto Satoshi 周東 智

SHUTO Satoshi 周東 智

SHUTOH Satoru 周東 智

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Medicinal chemistry for developing molecules regulating interactions between biological macromoleculesPrincipal Investigator

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A Versatile Strategy for Developing Long-Acting Ligands by Ligand-Phospholipid ConjugationPrincipal Investigator

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Medicinal chemistry studies based on the three-dimensional structural diversity-oriented molecular design of pharmacologically active compoundsPrincipal Investigator

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Design and synthesis of phosphatidylserine dimers with antitumor effect via the phagocytosis-inducing propertyPrincipal Investigator

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Medicinal chemical study by the three-dimensional structural diversity-oriented strategy based on the characteristic steric and stereoelectronic features of cyclopropanePrincipal Investigator

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Investigation of the mechanism of insulin secretion via CaPrincipal Investigator

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Useful β-turn mimetics having three-dimensional diversityPrincipal Investigator

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発達障害発症機序の解析と治療薬創製研究Principal Investigator

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Shuto Satoshi 周東智

SHUTO Satoshi 周東智

SHUTOH Satoru 周東智