• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

HASHIMOTO Yuichi  橋本 祐一

ORCIDConnect your ORCID iD *help
… Alternative Names

橋本 裕一  ハシモト ユウイチ

橋本 祐一  ハシモト ユウイチ

Less
Researcher Number 90164798
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2018 – 2019: 東京大学, 定量生命科学研究所, 教授
1997 – 2017: THE UNIVERSITY OF TOKYO,Insititute of Molecular and Cellular Biosciences, Professor, 分子細胞生物学研究所, 教授
1993 – 1996: 東京大学, 分子細胞生物学研究所, 助教授
1995: 東京大学, 分生研, 助教授
1990 – 1992: 東京大学, 応用微生物研究所, 助教授 … More
1990: 東京大学, 応微研, 助教授
1987 – 1988: 東京大学, 薬学部, 助手
1986: 東大, 薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Drug development chemistry / Chemical pharmacy / Biological Sciences / 医薬分子機能学 / Living organism molecular science
Except Principal Investigator
Chemical pharmacy / 医薬分子機能学 / Drug development chemistry
Keywords
Principal Investigator
サリドマイド / 構造展開 / レチノイド / フタルイミド / 核内受容体 / 阻害剤 / 構造活性相関 / アンタゴニスト / 核内受容体リガンド / 分子設計 … More / 抗アンドロゲン / 酵素阻害剤 / 腫瘍壊死因子 / マルチテンプレート / 生理活性物質 / アンドロゲン / 生物応答調節剤 / 医薬品化学 / アンドロゲンアンタゴニスト / thalidomide / 薬理シャペロン / プロテインノックダウン / シクロオキシゲナーゼ / 核内レセプター / 結合タンパク / molecular design / structural development / nuclear receptor / ケイ素 / 多重薬理 / ステロイド / ニーマン・ピック病C型 / 膜タンパク質 / 蛋白質相互作用 / 蛋白変性症 / フォールディング異常症 / トラフィッキング / タンパク質分解誘導 / PPAR / ビタミンD / チュブリン重合阻害剤 / 代謝物 / 一酸化窒素合成酵素 / アンドロジェン / グルコシダーゼ / 耐性克服 / アミノペプチターゼ / 血管新生 / 腫瘍壊死因子(TNF) / 生物学的応答調節剤 / 分子認識 / 発癌プロモーター / ヘミン / デキストラン / 核酸 / プロテインキナーゼC / フォルボールエステル / レセプター / グルココルチコイド受容体 / アンドロゲン受容体 / 酸性度 / エストロゲン受容体 / シラノール / チュブリン / プレグナンX受容体 / 構造変換 / バイオアイソスター / bioprobe / enzyme inhibitor / antagonists / steroid hormone / 抗リウマチ活性 / 抗糖尿病活性 / 一酸化窒素 / シクロオキシゲナーゼ阻害剤 / エストロゲン / ビタミンD_3 / バチェラジン / 組胞分化誘導 / ビタミンDアンタゴニスト / プロゲステロン / FXR / Farnesoid X Receptor (FXR) / Liver X Receptor (LXR) / 蛍光プローブ / ステロイドホルモン / ligand / enzyme inhibitors / androgen / retioids / 情報伝達物質 / シナージスト / ホモフタルイミド / ヘシン / リガンド / biological response modifier / enantio-dependence / bidirectional regulation / cell type / cytokine / phthalimide / tumor necrosis factor / 光学異性体 / 2方向性調節 / 光学活性依存性 / 細胞種 / サイトカイン / tumor promoter / receptor / nucleic acid / affinity labeling / porphyrin / retinoid / intercalator / dextran / 水溶性ポリマー / 塩基選択性 / ジヌクレオチド / インターカレーション / 受容体 / アフィニティーラベル / ポルフィリン / インターカレーター / NIH3T3 / トランスフォーメーション / DNA / 腫瘍遺伝子 / ブロモドメイン / ハンチンチン / コレステロール輸送 / 分子プロファイリング / NPC1L1 / フェナンスリジノン / スクリーニング / 局在異常 / コレステロール / 変異ロドプシン / 網膜色素変性症 / CRABPD / タンパク質分解 / レチノイン酸 / CRABP / ハイブリッド分子 / プロテアソーム / cIAP1 / ユビキチン / ベスタチン / タンパク質の自己分解 / 生物活性分子の設計・合成 / ジフェニルペンタン / 肝臓X受容体 / 生物応答調節 / 化合部物ライブラリー / ケミカルジェネティクス / 抗ウイルス剤 / ロドプシン / 細胞内局在 / テンプレート / フォールディング / 生物応答調節剤創製法 / 医薬分子機能学 / チュブリン重合阻害 / ヒストン脱アセチル化酵素 / 血管新生阻害 / ペプチダーゼ / 分化誘導 / アポトーシス / がん治療 / フェニルホモフタルイミド / フェニルフタルイミド / サブタイプ選択性 / 一酸化窒素合成酵素(NOS) / シクロオキシゲナーゼ(COX) / ヒストンデアセチラーゼ / 分化誘導促進活性 / 細胞浸潤阻害 / 前立腺がん細胞 / 医薬リード / がん細胞浸潤 / 細胞検定 / シクロオキシナーゼ / 変異型レセプター / イソキサゾロン骨格 / 前立腺がん / 細胞浸潤 / アミノペプチダーゼN / プロテアーゼ阻害剤 / 血管新生阻害剤 / 発癌プロモーション / シナ-ジスト / 薬物受容体 / 結合部位 / 質量分析 / レチノイン酸受容体 / アフィニティーゲル / 光親和性ラベル / ペプチド / ケイ光標識 / プローブ / プロテアーゼ / レチノイン酸レセプター / アフィニティラベル / エンドペプチダーゼ / パイレン / 塩基対合 / ヌクレアーゼ / ハイブリダイゼーション / 3重らせん / アンチセンス分子 / 発がんプロモーター / 熱ショックタンパクhsp90 / プロテインキナ-ゼC / フォルボ-ルエステル / タプシガルギン / 核内レセプタ- / 発がんプロモ-タ- … More
Except Principal Investigator
レチノイド / レチノイン酸 / チューブリン / 有糸分裂阻害剤 / レチノイドアンタゴニスト / キュラシンA / ウスチロキシン / 分化誘導 / 分化 / レセプター / 急性前骨髄球性白血病 / アンタゴニスト / ビタミンA / differentiation / leukemia / retinoic acid / retinoid / HL60 / 分子設計 / 白血病 / ビタミンA酸 / 細胞分化 / サリドマイド / アレナスタチンA / リウマチ / 癌 / 細胞内レチノイン酸結合蛋白 / Am-80 / 分化誘導療法 / PML / レチノイン酸レセプター / 複合体構造 / 分子認識 / 微小管機能 / 血管新生阻害 / 分子認識機構 / Maytansine部位 / Rhizoxin / Phomopsin A / 有糸分裂 / 血管新生 / 転移 / 形態形成 / レチノイドレセプタ- / チュ-ブリン / ミクロチスチン / オカダ酸クラス発がんプロモ-タ- / オカダ酸 / arenastatin A / curacin A / ustiloxins / molecular design / action mechanism / tubulin / antimitotic agent / 作用機作 / antagonist synergist / myeloma / tyroids / ベンゾラクタム / ジベンゾジアゼピン / フオルボール / チロキシン / 腫瘍悪性化 / チロイドリセプター / チロイド / ステロイド / 核レセプター / retinoid receptor / cancer / retinoid antagonist / vitamin A / シリコン / 癌治療 / 核レセプタ- / レチノイドレセプター / がん / X線結晶解析 / 核中レセプター / 酸異性化 / リセプタータンパク / カルコンカルボン酸・分化 / テレフタル酸アリリド / 癌治療薬 / 活性評価 / シクロオキシゲナーゼ / 核内受容体 / チューブリン重合阻害 / 腫瘍壊死因子(TNF)-α / 細胞増殖阻害 / α-グルコシダーゼ / LiverX受容体(LXR) / 代謝物 / 構造活性相関 / 構造展開 / 生物活性物質 / DNAチップ / アロディニア / PGE_2 / リアノジン受容体 / 15R-TIC / リピドA / Cu-ATSM / ダントロレン誘導体 / 4'-チオリボヌクレオシド / 可視化プローブ / RXRアンタゴニスト / プロスグランジン / 34mCl / キナーゼ阻害剤 / 光親和性標識法 / MicroPET / プラナーポジトロンイメージング / 神経性疼痛 / Socius / ABCトランスポーター / non-RI光親和性標識法 / 3成分連結PG合成法 / シグナル解析 / 神経因性疼痛 / 阻害剤 / キナーゼ / 人工核酸 / 蛍光プローブ / 高速メチル化 / PET / 亜砒酸 / RARA / 微小管 / 乾癖 / 核内レセプター / トランスジェニック・マウス / ユビキチン・プロテアゾーム / ブファリン / ポリプレン酸 / 分子誘導療法 / Ustiloxin / Dolastatin 10 / チロキシンレセプター / 鶏卵法検定 / 転移抑制 / 制がん剤 / プロテインキナ-ゼC / TRE / JE遺伝子 / アラキドン酸 / プロティンフォスファタ-ゼ / レチイン酸 / 分子進化 / Lーアラビノ-ス / レ-デオキシアデノシン / (dA)_6 / 三重鎖 / アンチセンスDNA / 核内レセプタ- / メイタンシン / リゾキシン / MAY部位 / VLB / 精密構造認識 / CNーTPBP / protein kinase C / プロスタグランジンE_2 / 蛋白質脱リン酸化酵素2A Less
  • Research Projects

    (51 results)
  • Research Products

    (223 results)
  • Co-Researchers

    (51 People)
  •  Structural and functional development studies of ligands for disease progression factorsPrincipal Investigator

    • Principal Investigator
      Hashimoto Yuichi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Development of silicon-containing units as expanded bioisostersPrincipal Investigator

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Polypharmacology based on dynamism of the target proteinPrincipal Investigator

    • Principal Investigator
      Hashimoto Yuichi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Chemical biology of trafficking regulation of membrane cholesterol transporter proteinPrincipal Investigator

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Chemical control of protein dramatypePrincipal Investigator

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Protein Knockdown Approach : Hybrid Small Molecules which Induce Proteasome Degradation of Target ProteinsPrincipal Investigator

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Living organism molecular science
    • Research Institution
      The University of Tokyo
  •  Biological response modification based on multi-template and dramatype approaches.Principal Investigator

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Thalidomide as a cell differentiation regulator

    • Principal Investigator
      NOGUCHI Tomomi
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Development of anti-tumor agents based on biological response modification.Principal Investigator

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  サリドマイドの抗糖尿病薬への展開Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  がん増悪因子を阻害する医薬リードの創製Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Design and development of biological response modifiersPrincipal Investigator

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      2002 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      医薬分子機能学
    • Research Institution
      The University of Tokyo
  •  サリドマイドの構造展開による、がん増悪因子を阻害する医薬リードの創製Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  生物新機能と創薬をめざす生体内分子科学

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      Gifu University
  •  サリドマイドの構造展開による,がん増悪因子を阻害する医薬リードの創製Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  ホルモンとしてのサリドマイド・・・細胞検定を指標にした構造展開Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Chemical pharmacy
    • Research Institution
      The University of Tokyo
  •  生物応答調節剤による発がん過程の修飾と予防Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  生物応答調節分子の設計と活性発現機構Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  Structural development of bio-active compounds affecting nuclear receptor functionPrincipal Investigator

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      The University of Tokyo
  •  生物応答調節分子の設計と活性発現機構Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  微小管機能を制御する超分子形成とリガンド機能の解析

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  エンドペプチダーゼ組み合わせ法によるレセプターラベル部位の決定Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      医薬分子機能学
    • Research Institution
      The University of Tokyo
  •  STUDIES ON THE ANTIMITOTIC AGENTS-TUBULIN INTERACTION AND DRUG DESIGN

    • Principal Investigator
      IWASAKI Shigeo
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES,THE UNIVERSITY OF TOKYO
  •  微小管機能を制御する超分子形成とリガンド機能の解析

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  レチノイドの化学・生物学・医学研究

    • Principal Investigator
      首藤 紘一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      The University of Tokyo
  •  Development of Phthalimide-type Novel Tumor Necrosis Factor (TNF) Production-regulatorsPrincipal Investigator

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  微小管機能を制御する超分子形成とリガンド機能の解析

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  発癌プロモーターとレチノイドのクロストークPrincipal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  がん細胞分化機構の分子生物学的の解明と分化誘導療法の臨床応用に関する基礎的研究

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  フタルイミド系新規TNF(腫瘍壊死因子)産生抑制剤の創製Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      The University of Tokyo
  •  Preparation of Functional Polylipid BiofactorsPrincipal Investigator

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  デキストラン法による脂溶性分子の水溶液中での挙動解析Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      The University of Tokyo
  •  Regulatory compound of nuclear receptor functions.

    • Principal Investigator
      SHUDO Koichi
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      University of Tokyo, Faculty of pharm.Sciences
  •  非細胞傷害性 抗がん化合物の合成と作用解析

    • Principal Investigator
      首藤 紘一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  発がんプロモーターの校内レセプターPrincipal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  有糸分裂阻害剤-チューブリン間の精密構造認識の解析

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  アンチセンス/エナンチオDNAPrincipal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      The University of Tokyo
  •  発がんプロモ-タ-の核内レセプタ-Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析

    • Principal Investigator
      IWASAKI Shigeo
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  核内レセプタ-応答遺伝子の認識分子

    • Principal Investigator
      SHUDO Koichi
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  臨床応用を目指す レチノイドの研究

    • Principal Investigator
      首藤 紘一
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Molecular design and synthesis of new retinoids

    • Principal Investigator
      SHUDO Koichi
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Univ. of Tokyo
  •  発がんプロモ-ションの機構とその阻害

    • Principal Investigator
      藤木 博太
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  発がんプロモ-ションの機構とその阻害

    • Principal Investigator
      藤木 博太
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  新しい作用機作をもつ抗がん剤の合成と特性

    • Principal Investigator
      首藤 紘一
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  ビタミンA酸および関連化合物による分化誘導とその作用機作

    • Principal Investigator
      首藤 紘一
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  新しい作用機作をもつ抗がん剤の合成と特性

    • Principal Investigator
      首藤 紘一
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  化学発癌物質によるオンコジンの化学修飾と活性化Principal Investigator

    • Principal Investigator
      橋本 祐一
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2002 Other

All Journal Article Presentation Book Patent

  • [Book] 生体有機化学2012

    • Author(s)
      橋本祐一・村田道雄 編著
    • Total Pages
      215
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Book] Interaction of biological response modifier with proteins. In "Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications"(ed. By Osada H)2009

    • Author(s)
      Hashimoto Y
    • Publisher
      (John Wiley & Sons, New Jersey)
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Book] ケミカルバイオロジー・ケミカルゲノミクス2005

    • Author(s)
      橋本祐一(分担執筆)
    • Total Pages
      278
    • Publisher
      シュプリンガー・フェアラーク東京
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Book] ケミカルバイオロジー・ケミカルゲノミクス2005

    • Author(s)
      橋本祐一(分担執筆), 半田宏 編
    • Total Pages
      278
    • Publisher
      シュプリンガー・フェアラーク東京
    • Data Source
      KAKENHI-PROJECT-15659025
  • [Book] ケミカルバイオロジー・ケミカルゲノミクス2005

    • Author(s)
      橋本祐一(分担執筆), 半田宏 編
    • Total Pages
      278
    • Publisher
      シュプリンガー・フェアラーク東京
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Book] ケミカルバイオロジー・ケミカルゲノミクス2005

    • Author(s)
      橋本祐一(分担執筆), 半田宏 編
    • Total Pages
      278
    • Publisher
      シュプリンガー・フェアラーク東京
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols2020

    • Author(s)
      Sagimori Ikuya、Yoshioka Hiromasa、Hashimoto Yuichi、Ohgane Kenji
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 28 Issue: 3 Pages: 115298-115298

    • DOI

      10.1016/j.bmc.2019.115298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-18J14851, KAKENHI-PROJECT-17K15487
  • [Journal Article] Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives2020

    • Author(s)
      Saito Hiroki、Matsumoto Yuichiro、Hashimoto Yuichi、Fujii Shinya
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 28 Issue: 4 Pages: 115310-115310

    • DOI

      10.1016/j.bmc.2020.115310

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22486, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17H03997
  • [Journal Article] Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins2020

    • Author(s)
      Yamashita Hiroko、Tomoshige Shusuke、Nomura Sayaka、Ohgane Kenji、Hashimoto Yuichi、Ishikawa Minoru
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 28 Issue: 1 Pages: 115175-115175

    • DOI

      10.1016/j.bmc.2019.115175

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K16326, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-18H02551, KAKENHI-PROJECT-17K15487
  • [Journal Article] Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton2019

    • Author(s)
      Nanjyo Shun、Ohgane Kenji、Yoshioka Hiromasa、Makishima Makoto、Hashimoto Yuichi、Noguchi- Yachide Tomomi
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 27 Issue: 10 Pages: 1952-1961

    • DOI

      10.1016/j.bmc.2019.03.042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06570, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17K15487
  • [Journal Article] Multiplexing fluorogenic esterase-based viability assay with luciferase assays2019

    • Author(s)
      Ohgane Kenji、Yoshioka Hiromasa、Hashimoto Yuichi
    • Journal Title

      MethodsX

      Volume: 6 Pages: 2013-2020

    • DOI

      10.1016/j.mex.2019.09.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-18J14851, KAKENHI-PROJECT-17K15487
  • [Journal Article] Design, synthesis and biological evaluateon of novel nonsteroidal progesterone receptor antagonists based on phenyl-1,3,5-triazine scaffold.2019

    • Author(s)
      Kaitoh Kazuma, Nakatsu Aki, Mori Shuji, Kagechika Hiroyuki, Hashimoto Yuichi, Fujii Shinya
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 67 Pages: 566-575

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Journal Article] Novel nonsteroidal progesterone receptor (PR) antagonists with a phenanthridinone skeleton.2018

    • Author(s)
      Yuko Nishiyama, Shuichi Mori, Madoka Nakagomi, Makoto Makishima, Shinya Fujii, Hiroyuki Kagechika, Yuichi Hashimoto, and Minoru Ishikawa
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 9 Pages: 641-645

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Journal Article] Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole2018

    • Author(s)
      Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 28 Issue: 4 Pages: 707-710

    • DOI

      10.1016/j.bmcl.2018.01.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996
  • [Journal Article] Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity.2018

    • Author(s)
      Toyama H, Shirakawa H, Komai M, Hashimoto Y, Fujii S.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 26 Issue: 15 Pages: 4493-4501

    • DOI

      10.1016/j.bmc.2018.07.038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03814, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17H03997, KAKENHI-PROJECT-16K15137
  • [Journal Article] Structural Development of Tetrachlorophthalimides as Liver X Receptor β (LXRβ)-Selective Agonists with Improved Aqueous Solubility2018

    • Author(s)
      Sayaka Nomura, Kaori Endo-Umeda, Shinya Fujii, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 28 Issue: 4 Pages: 796-801

    • DOI

      10.1016/j.bmcl.2017.12.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17H03997
  • [Journal Article] Development of nonsteroidal glucocorticoid receptor modulators based on N -benzyl- N -(4-phenoxyphenyl)benzenesulfonamide scaffold2017

    • Author(s)
      Yoshioka Hiromasa、Yamada Ayumi、Nishiyama Yuko、Kagechika Hiroyuki、Hashimoto Yuichi、Fujii Shinya
    • Journal Title

      Bioorganig and Medicinal Chemistry

      Volume: 25 Issue: 13 Pages: 3461-3470

    • DOI

      10.1016/j.bmc.2017.04.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17H03997, KAKENHI-PROJECT-16K15138
  • [Journal Article] Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein2017

    • Author(s)
      Hiromitsu Fukuda, Fumika Karaki, Kosuke Dodo, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kenji Ohgane
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 12 Pages: 2781-2787

    • DOI

      10.1016/j.bmcl.2017.04.062

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015
  • [Journal Article] Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression2017

    • Author(s)
      Yosuke Toyota, Sayaka Nomura, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Issue: 12 Pages: 2776-2780

    • DOI

      10.1016/j.bmcl.2017.04.061

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996
  • [Journal Article] Synthesis and evaluation of novel dual BRD4/HDAC inhibitors2017

    • Author(s)
      Amemiya Seika、Yamaguchi Takao、Hashimoto Yuichi、Noguchi-Yachide Tomomi
    • Journal Title

      Bioorganig and Medicinal Chemistry

      Volume: 25 Issue: 14 Pages: 3677-3684

    • DOI

      10.1016/j.bmc.2017.04.043

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
  • [Journal Article] Progress in the medicinal chemistry of silicon. -C/Si-Exchange and beyond-2017

    • Author(s)
      Fujii, S.,* Hashimoto, Y.
    • Journal Title

      Future Med. Chem.

      Volume: in press Issue: 5 Pages: 485-505

    • DOI

      10.4155/fmc-2016-0193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K15138, KAKENHI-PROJECT-16K15137, KAKENHI-PROJECT-17H03997
  • [Journal Article] Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists2017

    • Author(s)
      Ryuta Shioi, Shogo Okazaki, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Issue: 14 Pages: 3131-3134

    • DOI

      10.1016/j.bmcl.2017.05.037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
  • [Journal Article] Structure-activity relationship study of N6-benzoyladenine-type BRD4 inhibitors and their effects on cell differentiation and TNF-α production.2016

    • Author(s)
      Seika Amemiya, Takao Yamaguchi, Taki Sakai, Yuichi Hashimoto, Tomomi Nogichi-Yachide
    • Journal Title

      Chemal and Pharmaceutical Bulletin

      Volume: 64 Pages: 1378-1383

    • NAID

      130005261607

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Journal Article] Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317.2016

    • Author(s)
      Hirozumi Toyama, Shoko Sato, Hitoshi Shirakawa, Michio Komai, Yuichi Hashimoto, Shinya Fujii
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters

      Volume: 26 Pages: 1817-1820

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16K15137
  • [Journal Article] Development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists2016

    • Author(s)
      Sayaka Nomura, Kaori Endo-Umeda, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
    • Journal Title

      ChemMedChem

      Volume: 11 Issue: 20 Pages: 2347-2360

    • DOI

      10.1002/cmdc.201600305

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
  • [Journal Article] Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activit2016

    • Author(s)
      Shogo Okazaki, Tomomi Noguchi-Yachide, Taki Sakai, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Issue: 21 Pages: 5258-5269

    • DOI

      10.1016/j.bmc.2016.08.045

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K15137, KAKENHI-PROJECT-16K17930
  • [Journal Article] Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317.2016

    • Author(s)
      Toyama H, Sato S, Shirakawa H, Komai M, Hashimoto Y, Fujii, S.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 26 Issue: 7 Pages: 1817-1820

    • DOI

      10.1016/j.bmcl.2016.02.031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26292063, KAKENHI-PROJECT-26293025
  • [Journal Article] Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand2016

    • Author(s)
      Shusuke Tomoshige, Yuichi Hashimoto, Minoru Ishikawa
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Issue: 14 Pages: 3144-3148

    • DOI

      10.1016/j.bmc.2016.05.035

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-16K15137
  • [Journal Article] Discovery and structure-;activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors2015

    • Author(s)
      Noguchi-Yachide, T., Sakai, T., Hashimoto, Y., Yamaguchi, Y.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 23 Issue: 5 Pages: 953-959

    • DOI

      10.1016/j.bmc.2015.01.022

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-26810091, KAKENHI-PROJECT-15K08015
  • [Journal Article] Design and synthesis of novel ROR inverse agonists based on dibenzosilole scaffolds as a hydrophobic core structure2015

    • Author(s)
      Toyama, H.; Nakamura, M.; Hashimoto, Y.; Fujii, S.*
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Issue: 13 Pages: 2982-2988

    • DOI

      10.1016/j.bmc.2015.05.004

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-26293025
  • [Journal Article] Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules2015

    • Author(s)
      Shusuke Tomoshige, Mikihiko Naito, Yuichi Hashimoto, Minoru Ishikawa
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 13 Issue: 38 Pages: 9746-9750

    • DOI

      10.1039/c5ob01395j

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
  • [Journal Article] Design and synthesis of silicon-containing fatty acid amide derivatives as novel peroxisome proliferator-activated receptor (PPAR) agonists2015

    • Author(s)
      Daisuke Kajita, Masaharu Nakamura, Yotaro Matsumoto, Minoru Ishikawa, Yuichi Hashimoto and Shinya Fujii
    • Journal Title

      Bioorganic & Medicinal Chemistry Letter

      Volume: 25 Issue: 16 Pages: 3350-3354

    • DOI

      10.1016/j.bmcl.2015.05.045

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15J12421, KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
  • [Journal Article] Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.2015

    • Author(s)
      Taki Sakai, Yotaro Matsumoto, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto, Nobuhiko Wakai, Akio Kitao, Era Morishita, Chikashi Toyoshima, Tomoatsu Hayashi, Tetsu Akiyama
    • Journal Title

      Bioorg Med Chem.

      Volume: 23 Issue: 2 Pages: 328-339

    • DOI

      10.1016/j.bmc.2014.11.027

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-23370066, KAKENHI-PROJECT-24590136, KAKENHI-PLANNED-25104002, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
  • [Journal Article] Styrylphenylphthalimides as novel transrepression-selective liver X receptor (LXR) modulators2015

    • Author(s)
      Sayaka Nomura, Kaori Endo-Umeda, Atsushi Aoyama, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 6 Issue: 8 Pages: 902-907

    • DOI

      10.1021/acsmedchemlett.5b00170

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
  • [Journal Article] Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin- 6(5H)-one skeleton from a liver X receptor ligand2014

    • Author(s)
      Y.Nishiyama, M.Nakamura, T.Misawa, M.Nakagomi, M.Makishima, M.Ishikawa, Y.Hashimoto
    • Journal Title

      Boorg. Med. Chem.

      Volume: 22 Issue: 9 Pages: 2799-2808

    • DOI

      10.1016/j.bmc.2014.03.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-25670053
  • [Journal Article] Structure-activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout.2014

    • Author(s)
      Karaki, F., Ohgane, K., Fukuda, H., Nakamura, M., Dodo, K., Hashimoto, Y.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 22 Issue: 14 Pages: 3587-3609

    • DOI

      10.1016/j.bmc.2014.05.022

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-13J06522, KAKENHI-PROJECT-25670052, KAKENHI-PROJECT-26293025
  • [Journal Article] Structure–activity relationships of oxysterol-derived pharmacological chaperones for Niemann–Pick type C1 protein.2014

    • Author(s)
      Ohgane, K., Karaki, F., Noguchi-Yachide, T., Dodo, K. Hashimoto, Y.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 24 Issue: 15 Pages: 3480-3485

    • DOI

      10.1016/j.bmcl.2014.05.064

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-13J06522, KAKENHI-PROJECT-25670052, KAKENHI-PROJECT-26293025
  • [Journal Article] Structureactivity relationships of bisphenol A analogs at estrogen receptors (ERs) : discovery of an ERα-selective antagonist2013

    • Author(s)
      K. Maruyama, M. Nakamura, S. Tomoshige, K.Sugita, M.Makishima, Yuichi Hashimoto, M.Ishikawa
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Issue: 14 Pages: 4031-4036

    • DOI

      10.1016/j.bmcl.2013.05.067

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-24590136, KAKENHI-PROJECT-25670053
  • [Journal Article] タンパク質の折りたたみの異常を直すファーマコロジカルシャペロン~ニーマンピック病C 型治療薬を目指した試み~2013

    • Author(s)
      大金賢司、唐木文霞、闐闐孝介、橋本祐一
    • Journal Title

      現代化学

      Volume: No.512, 11月号 Pages: 48-54

    • URL

      http://www.tkd-pbl.com/news/nc243.html

    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect.2013

    • Author(s)
      Karaki, F. ; Ohgane, K. ; Dodo, K. ; Hashimoto, Y.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 21 Issue: 17 Pages: 5297-5309

    • DOI

      10.1016/j.bmc.2013.06.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J06522, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-25670052
  • [Journal Article] Discovery of Oxysterol-Derived Pharmacological Chaperones for NPC1 : Implication for the Existence of Second Sterol-Binding Site.2013

    • Author(s)
      大金賢司, 唐木文霞, 〓〓孝介, 橋本祐一
    • Journal Title

      Chemistry & Biology

      Volume: 20 Issue: 3 Pages: 391-402

    • DOI

      10.1016/j.chembiol.2013.02.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J10583, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-25670052
  • [Journal Article] フォールディング異常症に対する治療薬創製の可能性2012

    • Author(s)
      橋本祐一
    • Journal Title

      MEDCHEM NEWS

      Volume: 22 Pages: 25-28

    • NAID

      130007895543

    • URL

      http://medchem.pod.ne.jp/index.php?option=com_content&view=category&id=36&Itemid=56&lang=ja

    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]-azepin-6-one skeleton.2012

    • Author(s)
      Atsushi Aoyama
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 55 Issue: 17 Pages: 7360-7377

    • DOI

      10.1021/jm3002394

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107, KAKENHI-PROJECT-22249006
  • [Journal Article] Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist2012

    • Author(s)
      Y. Itoh, M. Ishikawa, R.Kitaguchi, K.Okuhira, M.Naito, Y.Hashimoto
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 22 Issue: 13 Pages: 4453-4457

    • DOI

      10.1016/j.bmcl.2012.04.134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048, KAKENHI-PROJECT-23790125
  • [Journal Article] Development oftarget protein-selective degradation inducerfor protein knockdown2011

    • Author(s)
      Y. Itoh, M. Ishikawa, R. Kitaguchi, S. Sato, M. Naito, Y. Hashimoto
    • Journal Title

      Bioorg. Med. Chem

      Volume: 19 Issue: 10 Pages: 3229-3241

    • DOI

      10.1016/j.bmc.2011.03.057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23659048
  • [Journal Article] フォールディング・トラフィッキング異常の修正作用を有するリガンドの創製~網膜色素変性症への応用を目指した、変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究~2011

    • Author(s)
      大金賢司,闐闐孝介,橋本祐一
    • Journal Title

      薬学雑誌

      Volume: 131 Pages: 325-334

    • NAID

      130000678893

    • URL

      https://www.jstage.jst.go.jp/browse/yakushi/131/3/_contents/-char/ja/

    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenetylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists2011

    • Author(s)
      K.Motoshima, K.Sugita, Y.Hashimoto, M.Ishikawa
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 21 Issue: 10 Pages: 3041-3045

    • DOI

      10.1016/j.bmcl.2011.03.026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Fused heterocyclic amide compounds as anti-hepatitis C virus agents2011

    • Author(s)
      Hiroshi Aoyama, Masahiko Nakamura
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 19 Issue: 8 Pages: 2675-2687

    • DOI

      10.1016/j.bmc.2011.03.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J09835, KAKENHI-PROJECT-22249006
  • [Journal Article] Further application of the multitemplate approach for creation of biological response modifiers : discovery of a new class of multifunctional anti-diabetic agents2011

    • Author(s)
      K.Motoshima, T.Noguchi-Yachide, M.Ishikawa, Y.Hashimoto, K.Sugita
    • Journal Title

      Heterocycles

      Volume: 82 Issue: 2 Pages: 1083-1101

    • DOI

      10.3987/rev-10-sr(e)7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Design, synthesis and biological evaluation of nuclear receptor-degradation inducers2011

    • Author(s)
      伊藤幸裕
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 19 Issue: 22 Pages: 6768-6778

    • DOI

      10.1016/j.bmc.2011.09.041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J09667, KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23790125
  • [Journal Article] Estrogen receptor α/β ligands derived from thalidomide2011

    • Author(s)
      T.Noguchi-Yachide, K.Sugita, Y.Hashimoto
    • Journal Title

      Heterocycles

      Volume: 83 Issue: 9 Pages: 2137-2147

    • DOI

      10.3987/com-11-12287

    • NAID

      40018958922

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Specific degradation of CRABP-II via cIAP1-mediatd ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein2011

    • Author(s)
      K. Okuhira, N. Ohoka, K. Sai, T. Nishimaki-Mogami, Y. Itoh, M. Ishikawa, Y. Hashimoto, M. Naito
    • Journal Title

      FEBS Lett.

      Volume: 585 Issue: 8 Pages: 1147-1152

    • DOI

      10.1016/j.febslet.2011.03.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048
  • [Journal Article] Peroxizome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists : relationship between absolute configuration and subtype selectivity2011

    • Author(s)
      K.Motoshima, M.Ishikawa, Y.Hashimoto, K.Sugita
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 19 Issue: 10 Pages: 3156-3172

    • DOI

      10.1016/j.bmc.2011.03.065

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Protein knockdown using methyl bestatin-ligand hybrid molecules : design andsynthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins2010

    • Author(s)
      Y. Itoh, M. Ishikawa, M. Naito, Y. Hashimoto
    • Journal Title

      J. Amer. Chem. Soc

      Volume: 132 Issue: 16 Pages: 5820-5826

    • DOI

      10.1021/ja100691p

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Journal Article] Retinobenzaldehydes as propertrafficking inducers of foldingdefective P23H rhodopsin mutant responsible for Retinitis Pigmentosa2010

    • Author(s)
      K.Ohgane, K.Dodo, Y.Hashimoto
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 18 Issue: 19 Pages: 7022-7028

    • DOI

      10.1016/j.bmc.2010.08.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Nitrogen-containing fused-heteroaromatic compounds as a anti-bovine diarrhea virus (BVDV) agents.2010

    • Author(s)
      Aoyama H, Baba M, Hashimoto Y
    • Journal Title

      Curr. Bioactive Comp. 6(2)

      Pages: 118-128

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators.2010

    • Author(s)
      Mita Y, Dodo K, Noguchi-Yachide T, Miyachi H, Makishima M, Hashimoto Y, Ishikawa M
    • Journal Title

      Bioorg. Med. Chem. Lett. 20(5)

      Pages: 1712-1717

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Novel selective anti-androgens with a diphenylpentane skeleton2010

    • Author(s)
      K.Maruyama, T.Noguchi-Yachide, K.Sugita, Y.Hashimoto, M.Ishikawa
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 20 Issue: 22 Pages: 6661-6666

    • DOI

      10.1016/j.bmcl.2010.09.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Protein knockdown using methyl bestatin-ligand hybrid molecule: design and sythesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.2010

    • Author(s)
      Itoh Y, Ishikawa M, Naito M, Hashimoto Y
    • Journal Title

      J. Amer. Chem. Soc. 132(16)

      Pages: 5820-5826

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Structural development studies of anti-hepatitis virus C virus agents2010

    • Author(s)
      M.Nakamura, A.Aoyama, M.T.M.Salim, M.Okamoto, M.Baba, M.Baba, H.Miyachi, Y.Hashimoto, H.Aoyama
    • Journal Title

      Bioorg. Med. Chem

      Volume: 18 Issue: 7 Pages: 2402-2411

    • DOI

      10.1016/j.bmc.2010.02.057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Structure-activity relationship of bis-galloyl derivatives related to(-)-epi-gallocatechin gallate.2009

    • Author(s)
      Kosuke Dodo, Taro Minato, Yuichi Hashimoto
    • Journal Title

      Chemical & Pharmaceutical Bulletin 57

      Pages: 190-194

    • NAID

      110007042048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Discovery of tetramethyltetrahydronaphthalene analogs as adult T-cell leukemia cells-selective proliferation inhibitors in a small chemical library constructed based on multi-template hypothesis.2009

    • Author(s)
      Nakamura M, Hamasaki T, Tokitou M, Baba M, Hashimoto Y, Aoyama H
    • Journal Title

      Bioorg. Med. Chem. 17(13)

      Pages: 4740-4746

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Structure-activity relationship of bis-galloyl derivatives related to (-)-epigallocatechin gallate2009

    • Author(s)
      Dodo, K., Minato, T., Hashimoto, Y.
    • Journal Title

      Chemical and Pharmaceutical Bulletin 57(2)

      Pages: 190-194

    • NAID

      110007042048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] マルチテンプレート手法によるサリドマイドの構造展開と活性拡張.2009

    • Author(s)
      橋本祐一
    • Journal Title

      和光純薬時報 77(1)

      Pages: 2-5

    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Diphenylpentane skeleton as a multi-template for steroid skeleton-recognizing receptors/enzymes.2009

    • Author(s)
      Hosoda S, Matsuda D, Tomoda H, Hashimoto Y
    • Journal Title

      Mini-Rev. Med. Chem. 9(5)

      Pages: 572-580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Structure-activity relationship of bis-galloyl derivatives related to(-)-epi-gallocatechin gallate2009

    • Author(s)
      Kosuke Dodo, Taro Minato, Yuichi Hashimoto
    • Journal Title

      Chemical & Pharmaceutical Bulletin 57

      Pages: 190-194

    • NAID

      110007042048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Enhancement of chemically-induced HL-60 cell differentiation by 3, 3'-diindolulmethane derivatives.2009

    • Author(s)
      Noguchi-Yachide T, Tetsuhashi M, Aoyama H, Hashimoto Y
    • Journal Title

      Chem. Pharm. Bull. 57(5)

      Pages: 536-540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] New tubulin-polymerization inhibitor derived from thalidomide: implication for anti-myeloma therapy.2008

    • Author(s)
      Kizaki M, Hashimoto Y
    • Journal Title

      Curr. Med. Chem. 15(8)

      Pages: 754-765

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] New tubulin-polymerization inhibitor derived from thalidomide:Implications for anti-myeloma therapy.2008

    • Author(s)
      Masahiro Kizaki and Yuichi Hashimoto
    • Journal Title

      Curr. Med. Chem. 15(8)

      Pages: 754-765

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] 4-(Anilino)pyrrole-2-carboxiamides: novel non-steroidal/non-anilide type androgen antagonisits effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor.2008

    • Author(s)
      Wakabayashi K, Imai K, Miyachi H, Hashimoto Y, Tanatani A
    • Journal Title

      Bioorg. Med. Chem. 16(14)

      Pages: 7046-7054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Structure-activity relationship of bis-galloyl derivatives related to(-)-epigallocatechin gallate.2008

    • Author(s)
      Kosuke Dodo, Taro Minato and Yuichi Hashimoto
    • Journal Title

      Chem. Pharm. Bull. 57(2)

      Pages: 190-194

    • NAID

      110007042048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Thalidomide as a multi-template for development of biologically active compounds.2008

    • Author(s)
      Hashimoto Y
    • Journal Title

      Arch. Pharm. Life Sci. 341(9)

      Pages: 536-547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Anriproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallate.2008

    • Author(s)
      Dodo K, Minato T, Noguchi-Yachide T, Suganuma M, Hashimoto Y
    • Journal Title

      Bioorg. Med. Chem. 16(17)

      Pages: 7975-7982

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] New tubulin polymerization inhibitor derived from thalidomide : Implications for anti-myeloma therapy2008

    • Author(s)
      Kizaki, M. and Hashimoto, Y.
    • Journal Title

      Current Medicianl Chemistry 15(8)

      Pages: 754-765

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Structural development of benzhydrol-type 1'-acetoxychavicol acetate (ACA) analogs as human leukemia cell-growth inhibitors based on quantitative structure-activity relationship (QSAR) analysis.2008

    • Author(s)
      Misawa T, Aoyama H, Furuyama T, Dodo K, Sagawa M, Miyachi H, Kizaki M, Hashimoto Y
    • Journal Title

      Chem. Pharm. Bull. 56(10)

      Pages: 1490-1495

    • NAID

      110006936309

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Co-existence of alpha-glucosidase-inhibitory activity and liver X receptor-regulatory activities and their separation by structural development.2008

    • Author(s)
      Dodo K, Aoyama H, Noguchi-Yachide T, Makishima M, Miyachi H, Hashimoto Y
    • Journal Title

      Bioorg. Med. Chem. 16(8)

      Pages: 4272-4285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Thalidomide as a multi-template for development of biologically active compounds.2008

    • Author(s)
      Yuichi Hashimoto
    • Journal Title

      Arch. Pharm. Life Sci. 341(9)

      Pages: 536-547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin.2008

    • Author(s)
      Sato S, Tetsuhashi M, Sekine K, Miyachi H, Naito M, Hashimoto Y, Aoyama H
    • Journal Title

      Bioorg. Med. Chem. 16(8)

      Pages: 4685-4698

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Thalidomide as a multi-template for development of biologically active compounds.2008

    • Author(s)
      Hashimoto Y
    • Journal Title

      Arch. Pharm. Life Sci 341(9)

      Pages: 536-547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Thalidomide as a multi-template for development of biologically active compounds2008

    • Author(s)
      Hashimoto, Y.
    • Journal Title

      Archives der Pharmazie, Life Science 341(9)

      Pages: 536-547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Structural development studies of nuclear receptor ligands.2007

    • Author(s)
      Hosoda S, Hashimoto Y
    • Journal Title

      Pure Appl. Chem. 79(4)

      Pages: 615-626

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Development of tubulin-polymerization inhibitors based on thalidomide skeleton.2007

    • Author(s)
      Aoyama H, Noguchi T, Misawa T, Nakamura T, Miyachi H, Hashimoto Y, Kobayashi H
    • Journal Title

      Chem. Pharm. Bull. 55(6)

      Pages: 844-949

    • NAID

      110006278705

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] 3, 3-Diphenylpentane skeleton as a steroid substitute: novel inhibitors for human 5α-reductase 1.2007

    • Author(s)
      Hosoda S, Hashimoto Y
    • Journal Title

      Bioorg. Med. Chem. Lett. 17(19)

      Pages: 5414-5418

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis.2006

    • Author(s)
      Fujimoto H, Noguchi T, Kobayashi H, Miyachi H, Hashimoto Y
    • Journal Title

      Chem. Pharm. Bull. 54(6)

      Pages: 855-860

    • NAID

      110004836392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferators-activated receptor α/σ dual agonists.2006

    • Author(s)
      J.Kasuga, M.Makishima, Y.Hashimoto, H.Miyachi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 16・3

      Pages: 554-558

    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] Nuclear receptor antagonists designed based on the helic-folding inhibition hypothesis.2005

    • Author(s)
      K.Hashimoto, H.Miyauchi
    • Journal Title

      Bioorganic & Medicinal Chemistry 13・17

      Pages: 5080-5093

    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.2005

    • Author(s)
      Miyachi H, Hashimoto Y
    • Journal Title

      Bioorg. Med. Chem. 13(17)

      Pages: 5080-5093

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] A new class androgen receptor antagonists bearing carborane in place of a steroidal skeleton.2005

    • Author(s)
      S.Fujii, Y.Hashimoto, T.Suzuki, Ohta, Y.Endo
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 15・1

      Pages: 227-230

    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.2005

    • Author(s)
      Y.Hashimoto
    • Journal Title

      Bioorg. Med. Chem. 13・17

      Pages: 5080-5093

    • Data Source
      KAKENHI-PROJECT-13NP0401
  • [Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis2005

    • Author(s)
      Yuichi Hashimoto, et al.
    • Journal Title

      Bioorganic & Medicinal Chemistry 13(17)

      Pages: 5080-5093

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.2005

    • Author(s)
      Yuichi Hashimoto, 他1名
    • Journal Title

      Bioorganic & Medicinal Chemistry 13・17

      Pages: 5080-5093

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] Novel non-steroidal/non-anilide type androgen antagonists : discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligand.2005

    • Author(s)
      K.Wakabayashi, H.Miyachi, Y.Hashimoto, A.Tanatani
    • Journal Title

      Bioorganic & Medicinal Chemistry 13・8

      Pages: 2837-2846

    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] 薬害の克服を目指した創薬化学:サリドマイドをマルチ創薬テンプレートとして活用したサリドマイドの構造展開と活性拡張2005

    • Author(s)
      宮地弘幸, 橋本祐一
    • Journal Title

      ファルマシア 41・1

      Pages: 33-37

    • Data Source
      KAKENHI-PROJECT-15659025
  • [Journal Article] サリドマイドとがん治療2005

    • Author(s)
      野口友美, 橋本祐一
    • Journal Title

      がん分子標的治療 3・1

      Pages: 16-23

    • Data Source
      KAKENHI-PROJECT-14030012
  • [Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004

    • Author(s)
      Yuichi Hashimoto 他3名
    • Journal Title

      Drugs Future 29・4

      Pages: 383-391

    • Data Source
      KAKENHI-PROJECT-15659025
  • [Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004

    • Author(s)
      Yuichi Hashimoto 他3名
    • Journal Title

      Drugs Future 24・9

      Pages: 383-391

    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004

    • Author(s)
      Yuichi Hashimoto, 他3名
    • Journal Title

      Drugs Future 29・4

      Pages: 383-391

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design2004

    • Author(s)
      Yuichi Hashimoto, et al.
    • Journal Title

      Drugs Future 29(4)

      Pages: 383-391

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004

    • Author(s)
      Yuichi Hashimoto 他6名
    • Journal Title

      Drugs Future 29・4

      Pages: 383-391

    • Data Source
      KAKENHI-PROJECT-14030012
  • [Journal Article] Structural development of biological response modifiers based on retinoids and thalidomide.2002

    • Author(s)
      Yuichi Hashimoto
    • Journal Title

      Mini-Reviews in Medicinal Chemistry 2・6

      Pages: 543-551

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] Structural development of biological response modifiers based on retinoids and thalidomide2002

    • Author(s)
      Yuichi Hashimoto
    • Journal Title

      Mini-Reviews in Medicinal Chemistry 2(6)

      Pages: 543-551

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.

    • Author(s)
      Y.Hashimoto
    • Journal Title

      Drugs Future (印刷中)

    • Data Source
      KAKENHI-PROJECT-13NP0401
  • [Patent] C型肝炎治療剤2010

    • Inventor(s)
      馬場昌範, 橋本祐一, 青山洋史, 中村政彦, 浦田泰生
    • Industrial Property Rights Holder
      国立大学法人鹿児島大学
    • Industrial Property Number
      2010-020502
    • Filing Date
      2010-02-01
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Patent] ジフェニルメタン誘導体を有効成分とする抗ウイルス剤2009

    • Inventor(s)
      馬場昌範, 岡本実佳, 後藤志典, モハメドタハ, アーメドサリム, 橋本祐一, 青山洋史, 細田信之介
    • Industrial Property Rights Holder
      国立大学法人鹿児島大学
    • Filing Date
      2009-03-13
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Patent] ベンズアルデヒド化合物2009

    • Inventor(s)
      大金賢司、橋本祐一
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2009-148965
    • Filing Date
      2009-06-23
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Patent] ベンズアルデヒド化合物2009

    • Inventor(s)
      大金賢司, 橋本祐一
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Number
      2009-148965
    • Filing Date
      2009-06-23
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Patent] 新規置換ビフェニルカルボン酸誘導体2009

    • Inventor(s)
      宮地弘幸, 橋本祐一, 春日淳一
    • Industrial Property Rights Holder
      国立大学法人岡山大学
    • Industrial Property Number
      2009-132055
    • Filing Date
      2009-06-01
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Patent] 三環性化合物2008

    • Inventor(s)
      宮地弘幸, 橋本祐一, 青山惇
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Number
      2008-050690
    • Filing Date
      2008-02-29
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Patent] 成人T細胞白血病治療薬2008

    • Inventor(s)
      馬場昌範、橋本祐一、永井勝幸
    • Industrial Property Rights Holder
      国立大学法人鹿児島大学
    • Industrial Property Number
      2008-256620
    • Filing Date
      2008-10-01
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Patent] 複素環誘導体2006

    • Inventor(s)
      棚谷綾, 宮地弘幸, 中川亜弥, 橋本祐一
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Number
      2006-021770
    • Filing Date
      2006-01-31
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Patent] 置換イソキサゾール誘導体2006

    • Inventor(s)
      宮地弘幸, 貝沼雅彦, 橋本祐一
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Number
      2006-054501
    • Filing Date
      2006-03-01
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Presentation] 独自の創薬手法・戦略に基づく生物応答調節剤の創製研究2020

    • Author(s)
      橋本祐一
    • Organizer
      日本薬学会第140年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] コレステロール合成酵素SMのフィードフォワード制御因子としてのスクアレン2020

    • Author(s)
      吉岡広大、Hudson W. Coates、Ngee Kiat Chua、橋本祐一、Andrew J. Brown、大金賢司
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] HMG-CoA還元酵素分解誘導剤SR12813の光親和性標識プローブ化2020

    • Author(s)
      豊田洋介、吉岡広大、鷺森郁也、橋本祐一、大金賢司
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] リン原子の創出する構造多様性に着目した生物活性化合物の創成研究(ホスフィノフェノール誘導体の構造物性相関とERリガンド活性)2019

    • Author(s)
      斎藤広樹、松本雄一朗、橋本祐一、藤井晋也
    • Organizer
      日本ケミカルバイオロジー学会第14会年会
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] ジフェニルホスフィン構造を基盤とした含リン化合物の性質の解明と医薬品構造要素としての有用性の検討2019

    • Author(s)
      齊藤広樹、松本雄一朗、橋本祐一、影近弘之、藤井晋也
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] Development of novel silicon-containing transcription modulators including sila-heterocyclic compounds.2019

    • Author(s)
      H. Toyama, D. Kajita, Y. Hashimoto, S. Fujiii
    • Organizer
      BIOHETEROCYCLES 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] Development of bioactive compounds based on bis-aryl (6-X-Y-6) skeleton.2019

    • Author(s)
      T. Noguchi-Yachide, K. Ohgane, Y. Hashimoto
    • Organizer
      BIOHETEROCYCLES 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] HMG-CoA還元酵素の分解を誘導する低分子化合物の構造活性相関とプローブ化2018

    • Author(s)
      鷺森郁也、吉岡広大、橋本祐一、大金賢司
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] ER downregulationの母格横断的な構造活性相関2018

    • Author(s)
      南條舜、谷内出友美、吉岡広大、槇島誠、石川稔、橋本祐一、大金賢司
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] ERダウンレギュレーターの構造活性相関2018

    • Author(s)
      谷内出友美、南條舜、大金賢司、橋本祐一
    • Organizer
      日本レチノイド研究会第29会学術集会
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] ビスフェノール構造を基盤としたケイ素官能基の構造物性および構造活性相関2018

    • Author(s)
      松本雄一朗、橋本祐一、藤井晋也
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K15137
  • [Presentation] ケイ素官能基をリンカー構造とするビスフェノール誘導体の構造物性相関と選択的エストロゲン受容体モジュレータへの展開2018

    • Author(s)
      松本雄一朗、橋本祐一、藤井晋也
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16K15137
  • [Presentation] Development of dual BRD4/HDAC inhibitors.2018

    • Author(s)
      Tomomi Noguchi-Yachide, Seika Amemiya, Takao Yamaguchi, and Yuichi Hashimoto
    • Organizer
      54th International Conference on Medicinal Chemistry (RICT 2018)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] ケイ素官能基をリンカー構造とするビスフェノール誘導体の構造物性相関と選択的エストロゲン受容体モジュレータへの展開2018

    • Author(s)
      松本雄一朗、橋本祐一、藤井晋也
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] Silyl groups as fancy isosteres of cis-diatomic functionalities: Development of novel nuclear receptor modulators bearing silyl functionality2018

    • Author(s)
      Shinya Fujii, Hirosumi Toyama, Daisuke Kajita, Yuichi Hashimoto
    • Organizer
      RICT 2018 54th International Conference on Medicinal Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15137
  • [Presentation] Silyl groups as fancy isosteres of cis-diatomic functionalities (Development of novel nuclear receptor modulators bearing silyl functionality)2018

    • Author(s)
      Shinya Fujii, Hirosumi Toyama, Daisuke Kajita, and Yuichi Hashimoto
    • Organizer
      54th International Conference on Medicinal Chemistry (RICT 2018)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] ItraconazoleのNPC1シャペロンとしての構造活性相関研究2018

    • Author(s)
      安藤有輝、塩井隆太、吉岡広大、谷内出友美、石川稔、橋本祐一、大金賢司
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] Transrepression作用選択的PPARγリガンドの創製を指向した構造活性相関研究2018

    • Author(s)
      豊田洋介、野村さやか、槇島誠、橋本祐一、石川稔
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] イトラコナゾールのNPC1に対するシャペロン作用に着目した構造活性相関研究2018

    • Author(s)
      安藤有輝、塩井隆太、吉岡広大、谷内出友美、石川稔、橋本祐一、大金賢司
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] 創薬化学における高周期元素の利用法の検討 - 種々の元素をリンカー構造に有するビスフェノール誘導体の構造物性相関および構造活性相関2018

    • Author(s)
      松本雄一朗、橋本祐一、藤井晋也
    • Organizer
      日本レチノイド研究会第29会学術集会
    • Data Source
      KAKENHI-PROJECT-16K15137
  • [Presentation] ホスフィネノール構造を基盤とする含リン化合物の構造物性相関と生物活性化合物への応用2018

    • Author(s)
      齊籐広樹、松本雄一朗、橋本祐一、藤井晋也
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] 神経変性疾患原因タンパク質のケミカルノックダウン2017

    • Author(s)
      友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] 神経変性疾患関連凝集タンパク質分解誘導剤の開発2017

    • Author(s)
      山下博子、友重秀介、野村さやか、大金賢司、橋本祐一、石川稔
    • Organizer
      日本ケミカルバイオロジー学会第12会年会
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] パーフルオロアルコール基の代替官能基としてのシラノール基の医薬的有用性の検討2017

    • Author(s)
      外山大純、橋本祐一、藤井晋也
    • Organizer
      日本ケミカルバイオロジー学会第12会年会
    • Data Source
      KAKENHI-PROJECT-16K15137
  • [Presentation] Phenanthridin-6(5H)-one骨格を有する非ステロイド型プロゲステロン受容体拮抗薬の創製2017

    • Author(s)
      西山郵子、森修一、槇島誠、藤井晋也、影近弘之、橋本祐一、石川稔
    • Organizer
      日本レチノイド研究会第28会学術集会
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] ドラッグリポジショニングによるニーマンピック病C型に対するシャペロンドラッグの探索2017

    • Author(s)
      (2)大金賢司、塩井隆太、安藤勇輝、谷内出友美、石川稔、どど幸介、袖岡幹子、橋本祐一
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17H03996
  • [Presentation] 新規アンドロゲン受容体AF-1モジュレーターの構造活性相関.2016

    • Author(s)
      沼館慧剛、梅田香織、槇島誠、橋本祐一、藤井晋也
    • Organizer
      日本レチノイド研究会第27回学術集会
    • Place of Presentation
      昭和薬科大学(東京都町田市)
    • Year and Date
      2016-10-22
    • Data Source
      KAKENHI-PROJECT-16K15137
  • [Presentation] Structural and functional development of retinoids/steroids.2016

    • Author(s)
      Yuichi Hashimoto
    • Organizer
      International Conference for the 70th Anniversary of Pharmaceutical Society of Korea
    • Place of Presentation
      The-K Hotel Seoul(韓国)
    • Year and Date
      2016-10-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15137
  • [Presentation] 新規BRD4/HDAC二重阻害活性化合物の創製.2016

    • Author(s)
      雨宮聖花、山口卓男、境太希、橋本祐一、谷内出友美
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] 小分子による蛋白変性疾患制圧のこころみ.2016

    • Author(s)
      橋本祐一
    • Organizer
      創薬懇話会 2016
    • Place of Presentation
      エクシブ蓼科(長野県茅野市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] AF-1領域による機能制御を指向した新規アンドロゲン受容体モジュレーターの創製2016

    • Author(s)
      沼館慧剛、谷内出友美、梅田香織、槇島誠、橋本祐一、藤井晋也
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] N6-ベンゾイルアデニン骨格を有する新規BRD4阻害剤の創製研究.2016

    • Author(s)
      谷内出友美、橋本祐一
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      大分県別府市別府国際コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] 核内受容体リガンドを指向した1,3,5-トリアジン誘導体の設計と構造展開2016

    • Author(s)
      海東和麻、谷内出友美、中津亜紀、森修一、橋本祐一、影近弘之、藤井晋也
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Structural and functional development of retinoids/steroids.2016

    • Author(s)
      Yuichi Hashimoto
    • Organizer
      International Conference for the 70th Anniversary of Pharmaceutical Society of Korea
    • Place of Presentation
      The-K Hotel Seoul(韓国)
    • Year and Date
      2016-10-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] PPARα/δデュアル転写誘導活性を有する新規ACC2阻害剤の創出.2016

    • Author(s)
      山口卓男、岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] ハンチントン病原因タンパク質の分解誘導薬の創製.2016

    • Author(s)
      友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] アンドロゲン受容体AF-1モジュレーターの構造展開.2016

    • Author(s)
      沼館慧剛、谷内出友美、梅田香織、槇島誠、橋本祐一、藤井晋也
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-16K15137
  • [Presentation] ベンゾイルアデニン骨格を有する新規BRD4阻害剤の創製2016

    • Author(s)
      雨宮聖花、境太希、橋本祐一、山口卓男、谷内出友美
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Huntingtinタンパク質を減少させるSNIPER化合物の創製2016

    • Author(s)
      友重秀介、大金賢司、内藤幹彦、石川稔、橋本祐一
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] PPARα/δデュアル転写誘導活性を有する新規ACC2阻害剤の創出.2016

    • Author(s)
      吉岡広大、西山郵子、山田歩、影近弘之、橋本祐一、藤井晋也
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-16K15137
  • [Presentation] 新規骨格構造を有する非ステロイド型GRリガンドの探索と構造展開.2016

    • Author(s)
      吉岡広大、西山郵子、山田歩、影近弘之、橋本祐一、藤井晋也
    • Organizer
      日本レチノイド研究会第27回学術集会
    • Place of Presentation
      昭和薬科大学(東京都町田市)
    • Year and Date
      2016-10-22
    • Data Source
      KAKENHI-PROJECT-16K15137
  • [Presentation] Design and synthesis of novel ROR inverse agonists based on silicon-containing hetgerocyclic core structure2015

    • Author(s)
      H. Toyama, M. Nakamura, Y. Hashimoto, S. Fujii
    • Organizer
      PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
    • Place of Presentation
      Honolulu, Hawaii (USA)
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Discovery and optimization of distinctive nuclear receptors modulators (I): Inhibitors of the interaction of VDR with coactivators, and nuclear receptors-degradation inducers2015

    • Author(s)
      Minoru Ishikawa, Yusuke Mita, Yukihiro Itoh, Risa Kitaguchi, Makoto Makishima, and Yuichi Hashimoto
    • Organizer
      The 3rd International Conference on Retinoids
    • Place of Presentation
      岐阜グランドホテル(岐阜県岐阜市)
    • Year and Date
      2015-10-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Transrepression作用選択的なLXRリガンドの創製2015

    • Author(s)
      野村さやか、遠藤(梅田)香織、青山惇、槇島誠、橋本祐一、石川稔
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      幕張国際研究センター(千葉県千葉市)
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Development of transrepression-selective liver X receptor (LXR) ligands2015

    • Author(s)
      S. Nomura, K. Endo-Umeda, A. Aoyama, M. Ishikawa, M. Makishima, Y. Hashimoto
    • Organizer
      PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
    • Place of Presentation
      Honolulu, Hawaii (USA)
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Novel BRD4 inhibitors with a N6-benzoyladenine skeleton2015

    • Author(s)
      T. Noguchi-Yachide, T. Sakai, Y. Hashimoto, T. Yamaguchi
    • Organizer
      PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
    • Place of Presentation
      Honolulu, Hawaii (USA)
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Retinoids/steroids as ligands for pharmacological chaperons and protein knockdown approach2015

    • Author(s)
      Yuichi Hashimoto
    • Organizer
      AIMECS 2015 (10th AFMC International Medicinal Chemistry Symposium), Oct. 18-21, 2015 (Korea, ICC JELU)
    • Place of Presentation
      Korea, ICC JELU
    • Year and Date
      2015-10-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Retinoids/steroids as ligands for pharmacological chaperons and protein knockdown approach2015

    • Author(s)
      Yuichi Hashimoto
    • Organizer
      RICT 2015 (Rencontres Internationales de Chimie Therapeutique)
    • Place of Presentation
      Avignon, France
    • Year and Date
      2015-07-01
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] フェナンスリジノン骨格を有するステロイドホルモン受容体リガンドの創製2015

    • Author(s)
      西山郵子、藤井晋也、石川稔、橋本祐一、槇島誠
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      幕張国際研究センター(千葉県千葉市)
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Development of silicon-based biological active compounds by focusing on silyl functionality as a cis-olefin mimetic2015

    • Author(s)
      D. Kajita, M. Nakamura, Y. Matsumoto, M. Ishikawa, Y. Hashimoto, S. Fujii
    • Organizer
      PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
    • Place of Presentation
      Honolulu, Hawaii (USA)
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] 新規PPARαアゴニストの探索と構造展開、およびhACC2阻害活性評価2015

    • Author(s)
      岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一、山口卓男
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      幕張国際研究センター(千葉県千葉市)
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Discovery and optimization of distinctive nuclear receptor modulators (II): Transrepression selective LXR ligands, and LXRβ selective agonists2015

    • Author(s)
      Minoru Ishikawa, Sayaka Nomura, Atsushi Aoyama, Kaori Endo-Umeda, Kazunori Motoshima, Makoto Makishika, and Yuichi Hashimoto
    • Organizer
      The 3rd International Conference on Retinoids
    • Place of Presentation
      岐阜グランドホテル(岐阜県岐阜市)
    • Year and Date
      2015-10-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Polypharmacological profiles of phenathridinone derivatives2015

    • Author(s)
      Y. Nishiyama, T. Misawa, H. Aoyama, S. Fujii, M. Ishikawa, Y. Hashimoto
    • Organizer
      PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
    • Place of Presentation
      Honolulu, Hawaii (USA)
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Development of androgen receptor (AR) activation function-1 (AF-1) modulators2015

    • Author(s)
      Shinya Fujii, Akiyoshi Numadate, Tomomi Noguchi-Yachide, Kaori Endo-Umeda, Makoto Makishima, and Yuichi Hashimoto
    • Organizer
      The 3rd International Conference on Retinoids
    • Place of Presentation
      岐阜グランドホテル(岐阜県岐阜市)
    • Year and Date
      2015-10-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] マルチテンプレート手法を用いた新規TGR5 リガンドの創製研究2014

    • Author(s)
      小針孝夫、三澤隆史、橋本祐一
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] NPC1 の局在異常を修正する非ステロイド性リガンドの創製研究2014

    • Author(s)
      福田寛充、大金賢司、唐木文霞、闐闐孝介、橋本祐一
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] 膠芽腫幹細胞を標的としたsirtuin2 阻害剤の創製研究2014

    • Author(s)
      境太希、若井信彦、松本洋太郎、林寛敦、石川稔、杉田和幸、北尾彰朗、秋山徹、橋本祐一
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] 神経変性疾患原因タンパク質分解誘導剤の創製研究2013

    • Author(s)
      友重秀介、北口梨沙、大金賢司、石川稔、内藤幹彦、橋本祐一
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] Retinoids as ligands for pharmaceutical chaperone and protein knockdown approach2012

    • Author(s)
      Y. Hashimoto
    • Organizer
      The 1st International Symposium on Latent TGF-βActivation Reaction
    • Place of Presentation
      Kobe
    • Year and Date
      2012-02-25
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteosomal degradation of target protein2012

    • Author(s)
      M. Naito, K. Okuhira, N. Ohoka, N. Shibata, T. Hattori, Y. Itoh, M. Ishikawa, Y. Hashimoto
    • Organizer
      The Sixth International Conference. SUMO, Ubiquitin, UBL Proteins
    • Place of Presentation
      Houston
    • Year and Date
      2012-02-08
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] PFIC2 の原因となる変位型BSEP の機能を修正する新規小分子の発見と構造展開2012

    • Author(s)
      三澤隆史、林久允、杉山雄一、橋本祐一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] タンパク質ノックダウン法を利用した新治療戦略と低分子の標的タンパク質同定法2012

    • Author(s)
      石川稔、どど孝介、伊藤幸裕、淺沼三和子、佐藤伸一、袖岡幹子、内藤幹彦、橋本祐一
    • Organizer
      日本ケミカルバイオロジー学会第7回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] サリドマイド由来エストロゲン受容体リガンドの創製2012

    • Author(s)
      谷内出友美、杉田和幸、松本洋太郎、橋本祐一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] NPC1 変異体のフォールディング効率低下をrescue するステロール誘導体の発見、およびNPC1 の第二のステロール結合部位の存在2012

    • Author(s)
      大金賢司、唐木文霞、闐闐孝介、橋本祐一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] Retinoids as ligands for pharmaceutical chaperone and protein knockdown approach2012

    • Author(s)
      Yuichi Hashimoto
    • Organizer
      The 1st International Symposium on Latent TGF-β Activation Reaction
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2012-02-25
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] 疫調節作用選択的な肝臓X受容体(LXR)リガンドの創製2012

    • Author(s)
      青山惇、梅田(遠藤)香織、岸田健治、大金賢司、谷内出(野口)友美、青山洋史、石川稔、宮地弘幸、槇島誠、橋本祐一
    • Organizer
      日本レチノイド研究会第23回学術集会
    • Place of Presentation
      米子
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] Pharmacological chaperones and protein knockdown inducers derived from nuclear receptor ligands2012

    • Author(s)
      Y.Hashimoto
    • Organizer
      The 23^<rd> Symposium of Retinoids
    • Place of Presentation
      Yonago
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] プロテインノックダウン法を利用した核内受容体分解誘導低分子の創製2011

    • Author(s)
      北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-28
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] 核内受容体を細胞内で選択的に分解誘導する分子の創製2011

    • Author(s)
      北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
    • Organizer
      日本レチノイド研究会第22回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-11
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] Protein knockdown : selective degradation of target proteins in cells using methyl bestatin-ligand hybrid molecules2011

    • Author(s)
      M. Ishikawa, Y. Itoh, R. Kitaguchi, S. Sato, M. Naito, Y. Hashimoto
    • Organizer
      AIMECS 2011
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-11-29
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン技術の検討2011

    • Author(s)
      奥平桂一郎、大岡伸通、最上(西巻)知子、橋本祐一、内藤幹彦
    • Organizer
      日本がん分子標的治療学会第15回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-22
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] タンパク質の形と存在状態を狙う生理活性物質の創製2011

    • Author(s)
      橋本祐一
    • Organizer
      平成23年度後期(秋季)有機合成化学講習会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] タンパク質の形と存在状態を狙う生理活性物質の創製2011

    • Author(s)
      橋本祐一
    • Organizer
      平成23年度後期(秋季)有機合成化学講習会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-17
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] プロテインノックダウン法の開発~低分子CRABP分解誘導剤の創製~2010

    • Author(s)
      伊藤幸裕, 石川稔, 内藤幹彦, 橋本祐一
    • Organizer
      第8回次世代の担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] Selective anti-androgens with a 3,3-diphenylpentane skeleton2010

    • Author(s)
      K.Maruyama, M.Ishikawa, T.Noguchi-Yachide, Y.Hashimoto
    • Organizer
      International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] ケミカルジェネティクスと創薬のための活性物質創製法2010

    • Author(s)
      橋本祐一
    • Organizer
      創薬懇話会2009
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] Protein knockdown using ubiquitination activity of cIAP1 : Discoveryof CRABP degradation inducers.2010

    • Author(s)
      Y. Itoh, M. Ishikawa, M. Naito, Y. Hashimoto
    • Organizer
      PACIFICHEM 2010
    • Place of Presentation
      Honolulu
    • Year and Date
      2010-12-15
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] ニーマンピック病C型の原因となるNPC1 変異体のフォールディング・トラフィッキング異常を修正する低分子化合物の発見と構造活性相関2010

    • Author(s)
      大金賢司、闐闐孝介、橋本祐一
    • Organizer
      第29回メディシナルケミストリーシンポジウム講演要旨集
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] 変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究---網膜色素変性症への応用を目指して---2010

    • Author(s)
      大金賢司、どど孝介、橋本祐一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] プロテインノックダウン法の開発2010

    • Author(s)
      伊藤幸裕、石川稔、内藤幹彦、橋本祐一
    • Organizer
      第8回次世代を担う有機科学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-05-13
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] プロテインノックダウン法を利用したAR 分解誘導剤の創製2010

    • Author(s)
      北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
    • Organizer
      第29回メディシナルケミストリーシンポジウム講演要旨集
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] Multi-template and dramatype approaches for lead generation2010

    • Author(s)
      橋本祐一
    • Organizer
      第3回高度医療都市を創出する未来技術国際シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2010-02-03
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Presentation] Multi-template and dramatype approaches for lead generation.2010

    • Author(s)
      橋本祐一
    • Organizer
      第3回高度医療都市を創出する未来技術国際シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2010-02-03
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] 細胞内レチノイド結合タンパク質の分解を誘導するレチノイン酸連結化合物の創製2010

    • Author(s)
      石川稔、伊藤幸裕、内藤幹彦、橋本祐一
    • Organizer
      日本ビタミン学会第62回大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-06-11
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] 変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究~網膜色素変性症への応用を目指して~2010

    • Author(s)
      大金賢司, 〓〓孝介, 橋本祐一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] プロテインノックダウン法を利用した創薬指向型CRABP分解誘導剤の創製2010

    • Author(s)
      伊藤幸裕、石川稔、奥平桂一郎、内藤幹彦、橋本祐一
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] シーズ創製のためのマルチテンプレート法とドラマタイプ法2010

    • Author(s)
      橋本祐一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] シーズ創製のためのマルチテンプレート法とドラマタイプ法.2010

    • Author(s)
      橋本祐一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] シーズ創製のためのマルチテンプレート法とドラマタイプ法2010

    • Author(s)
      橋本祐一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Presentation] Protein knockdown using ubiquitination activity of cIAP1 : Discovery of CRABP degradation inducers2010

    • Author(s)
      Y.Itoh, M.Ishikawa, M.Naito, Y.Hashimoto
    • Organizer
      International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] フタルイミド骨格を基盤としたトリプターゼ阻害剤の創製2009

    • Author(s)
      鉄橋正士、橋本祐一、青山洋史
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-26
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] 3,3-diindolylmethane (DIM)誘導体におけるHL-60細胞分化促進活性2009

    • Author(s)
      谷内出友美、鉄橋正士、青山洋史、橋本祐一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] マルチテンプレート手法とドラマタイプ手法に基づく生物活性物質の創製2009

    • Author(s)
      橋本祐一
    • Organizer
      日本化学会第3回関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-05
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] 変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究~網膜色素変性症への応用を目指して~2009

    • Author(s)
      大金賢司、どど孝介、橋本祐一
    • Organizer
      日本レチノイド研究会第20回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] 3, 3-diindolylmethane (DIM)誘導体におけるHL-60細胞分化促進活性2009

    • Author(s)
      谷内出友美、鉄橋正士、青山洋史、橋本祐一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Presentation] ケミカルジェネティクスと創薬のための活性物質創製法2009

    • Author(s)
      橋本祐一
    • Organizer
      創薬懇話会2009
    • Place of Presentation
      岐阜
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] 変異型ロドプシンのフォールディングを促進する低分子化合物による網膜色素変性症治療薬創製研究2009

    • Author(s)
      大金憲司、〓〓孝介、橋本祐一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] 変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究~網膜色素変性症への応用を目指して~2009

    • Author(s)
      大金賢司、どど孝介、橋本祐一
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-26
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] シーズ創製のためのマルチテンプレート法とドラマタイプ法2009

    • Author(s)
      橋本祐一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-21651092
  • [Presentation] マルチテンプレート手法とドラマタイプ手法に基づく生物活性物質の創製2009

    • Author(s)
      橋本祐一
    • Organizer
      日本化学会第3回関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-05
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Presentation] ネクローシスの分子機構解明を目指した新規細胞死誘導剤の創製2009

    • Author(s)
      佐藤伸一、どど孝介、滕玉鴎、橋本祐一、袖岡幹子
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] ステロイド代替骨格として機能するジフェニルペンタン誘導体の創製---核内受容体リガンドとHMG-CoA還元酵素阻害剤---2008

    • Author(s)
      細田信之介、松田大介、供田洋、橋本祐一
    • Organizer
      第27回メディシナルケミストリーシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-26
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] Biological response modifiers derived from thalidomide.2007

    • Author(s)
      Yuichi Hashimoto
    • Organizer
      The 12th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-12-04
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Presentation] Biological response modiifiers derived from thalidomide2007

    • Author(s)
      Yuichi Hashimoto
    • Organizer
      The 12^th Japanese Foundation for Chncer Research International Symposium on Cancer Chemotherapy
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-12-04
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] ケイ素とcisオレフィンの可換性に着目した含ケイ素PPARアゴニストの創製

    • Author(s)
      梶田大資、中村雅陽、松本洋太郎、石川稔、橋本祐一、藤井晋也
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] 含ケイ素抗エストロゲン様活性物質の創製

    • Author(s)
      梶田大資、中村雅陽、松本洋太郎、橋本祐一
    • Organizer
      日本レチノイド研究会第25回学術集会
    • Place of Presentation
      秋田
    • Year and Date
      2014-10-11 – 2014-10-12
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] ステロイド代替骨格としてのジフェニルメタン骨格~胆汁鬱滞性疾患治療薬への展開~

    • Author(s)
      小針孝夫、細田信之介、貝沼雅彦、三澤隆、藤井晋也、橋本祐一
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] 核内受容体選択的なCoactivator Binding Inhibitorの創製研究

    • Author(s)
      福田寛充、槇島誠、石川稔、藤井晋也、橋本祐一
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Transrepression作用選択的なスチニルフェニルフタルイミド骨格を有するLXRリガンドの創製

    • Author(s)
      野村さやか、石川稔、槇島誠、青山惇、橋本祐一
    • Organizer
      日本レチノイド研究会第25回学術集会
    • Place of Presentation
      秋田
    • Year and Date
      2014-10-11 – 2014-10-12
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] フェナンスリジノン誘導体の多重薬理学的プロファイリング

    • Author(s)
      西山郵子、中村政彦、三澤隆史、青山洋史、杉田和幸、石川稔、橋本祐一、中込まどか、槇島誠、馬場昌範
    • Organizer
      第32回メディシナルケミストリーシンポジウム講演要旨集
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-26 – 2014-11-28
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] フェナンスリジノン誘導体の多重薬理学的プロファイリング

    • Author(s)
      西山郵子、中村政彦、三澤隆史、青山洋史、杉田和幸、石川稔、橋本祐一、中込まどか、槇島誠、馬場昌範
    • Organizer
      第32回メディシナルケミストリ-シンポジウム
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2014-11-26 – 2014-11-28
    • Data Source
      KAKENHI-PROJECT-25670052
  • [Presentation] LXR(Liver X Receptor)β選択的アゴニストの創製

    • Author(s)
      野村さやか、石川稔、橋本祐一、梅田(遠藤)香織、槇島誠
    • Organizer
      第32回メディシナルケミストリーシンポジウム講演要旨集
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-26 – 2014-11-28
    • Data Source
      KAKENHI-PROJECT-26293025
  • 1.  KAGECHIKA Hiroyuki (20177348)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 2.  ENDO Yasuyuki (80126002)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 1 results
  • 3.  IWASAKI Shigeo (00013326)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 4.  SHUDO Koichi (50012612)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 5.  KOBAYASHI Hisayoshi (80225531)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 2 results
  • 6.  NOGUCHI Tomomi (20401284)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 26 results
  • 7.  KOISO Yuikiko (50092200)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 8.  SHIRAI Ryuichi (80183838)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 9.  OHWADA Tomohiko (20177025)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  NAGASAWA Kazuo (10247223)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  ISHIKAWA Minoru (70526839)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 49 results
  • 12.  FUJII Shinya (60389179)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 33 results
  • 13.  MORISAKI Naoko (00092354)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 14.  大野 竜三 (70093002)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 15.  本間 良夫 (70142114)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 16.  武藤 泰敏 (20010069)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 17.  直江 知樹 (50217634)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 18.  AOYAMA Hiroshi (40374699)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 19.  藤木 博太 (60124426)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 20.  深見 泰夫 (00156746)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 21.  野瀬 清 (70012747)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 22.  大内 和雄 (20006357)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 23.  垣塚 彰 (80204329)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 24.  袖岡 幹子 (60192142)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 25.  SUGITA Kazuyuki (60542090)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 26.  MATSUMOTO Yotaro (90420041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 27.  MISAWA Takashi (40709820)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 28.  MIYACHI Hiroyuki (20376643)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 29.  TANATANI Aya (40361654)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 30.  石川 隆俊 (30085633)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  上村 大輔 (00022731)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  柴崎 正勝 (30112767)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  梅沢 一夫 (70114402)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  鈴木 正昭 (90093046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  渡辺 恭良 (40144399)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  松田 彰 (90157313)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  石川 智久 (60193281)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  伊藤 誠二 (80201325)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  萩原 正敏 (10208423)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  根岸 学 (60201696)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  鈴木 和年 (90162932)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  米倉 義晴 (60135572)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  森 望 (00130394)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  長野 哲雄 (20111552)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  浦野 泰照 (20292956)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  大金 賢司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 47.  白川 仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 48.  駒井 三千夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 49.  秋山 徹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 50.  友重 秀介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 51.  伊藤 幸裕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi