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Takano Hiroshi  高野 洋志

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TAKANO Hiroshi  高野 洋志

高野 洋志  タカノ ヒロシ

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Researcher Number 00241555
Affiliation (Current) 2025: 公益財団法人がん研究会, がん研究所 細胞生物部, 主任研究員
Affiliation (based on the past Project Information) *help 2019 – 2023: 公益財団法人がん研究会, がん研究所 細胞生物部, 主任研究員
2015: 公益財団法人がん研究会, がん研究所・細胞生物部, 特任研究員
2015: 公益財団法人がん研究会, がん研究所 細胞生物部, 特任研究員
2013: 公益財団法人がん研究会, がん研究所 細胞生物部, 研究員
2012: 公益財団法人がん研究会, がん研究所細胞生物部, 研究員 … More
2009: 財団法人癌研究会, 癌研究所細胞生物部, 研究員
2009: 財団法人癌研究会, 細胞生物部, 研究員
2007 – 2008: 財団法人癌研究会, ゲノムセンター, 研究員
2006: 東北大学, 大学院・医学系研究科, 助手
2004 – 2005: Tohoku Univ, School of Medicine, Research Associate, 大学院医学系研究科, 助手
1999 – 2004: 東北大学, 大学院・医学系研究科, 助手
2001: 助手
1998: 東北大学, 医学部, 助手
1996: 財団法人癌研究會, 癌研究所・細胞生物部, 研究員
1996: 財団法人癌研究會, 癌研究所細胞生物部, 研究員
1994: 癌研究所 細胞生物部, 研究員 Less
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Laboratory animal science / Cell biology
Except Principal Investigator
Biological Sciences / Genetics/Genome dynamics / Molecular biology / Laboratory animal science
Keywords
Principal Investigator
モデルマウス / 染色体構造異常 / 染色体異常 / 大腸がん / PCNA / マウス / クロモスリプシス / 微小核 / MpsI / AIDシステム … More / B1 SINE / Kras / APC / ゲノム編集 / マウスモデル / mutated estrogen receptr / tamoxifen / Cre recombinase / inducible gene targeting / mouse / Cre組み換え酵素 / 変異エストロジェンレセプター / タモキシフェン / Cre組換え酵素 / インデューシブル・ジーンターゲティング / 胚発生 / 矮小化 / 神経系 / ジーンターゲティング / mgl-2 / mgl-1 / 1(2)gl … More
Except Principal Investigator
癌 / ゲノム / ジーンターゲティング / 老化 / 染色体 / 遺伝子 / Chromosome / Cancer / Aging / Genome / PTEN / APC / Patched / ノックアウトマウス / p53遺伝子 / VHL遺伝子 / βカテニン / Cre組換え酵素 / β-catenin / PTEN遺伝子 / ARF遺伝子 / SMAD4遺伝子 / 癌抑制遺伝子 / がん分子標的薬剤 / ATL発症リスク / ATL発がん機序 / がん化学予防 / 分子疫学コーホート研究 / ATL発症予防 / 国際交流 / 個別化がん予防 / ゲノム・エピゲノム解析支援 / アカデミア創薬 / 次世代分子解析技術 / ゲノムコーホート研究 / 病理形態学 / 遺伝子改変マウス / 国際研究者交流 / 若手支援 / シグナル伝達 / モデル動物 / シグナル / 遺伝学 / 修復 / 組み換え / ヘリケース / MLH1遺伝子 / モデルマウス / がん抑制遺伝子 / アデノウイルスベクター / コンディショナル・ノックアウト / 膵癌 / 大腸癌 / βカテニン遺伝子 / ノックアウト・マウス / WNTシグナル / ケラチン14遺伝子 / APC遺伝子 / コンディショナル・ジーンターゲティング / 胎仔性肝造血 / LoxP配列 / PEBP2β遺伝子 / AML1遺伝子 / PEBP2αB遺伝子 / ヒト白血病 / 高度難聴 / 海馬 / Brn-4遺伝子 / Brn-2遺伝子 / Brn-1遺伝子 / POU転写因子 / ES再細胞 / 条件依存性変異 / P1ファジ- / Cre酵素 / LoxP / 標的組換え Less
  • Research Projects

    (16 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (138 People)
  •  マウスにおける染色体異常誘導系を用いた大腸がん進展に関わるゲノム構造異常の解析Principal Investigator

    • Principal Investigator
      高野 洋志
    • Project Period (FY)
      2023 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Induction of chromosome aberrations by Pulse Genome Editing system in mouse intestinal tumorPrincipal Investigator

    • Principal Investigator
      TAKANO Hiroshi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

    • Principal Investigator
      IMAI Kohzoh, 中村 祐輔
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      The University of Tokyo
  •  Identification of molecular targets for cancer therapeutics through the analysis of tumor formation in mouse models for human carcinogenesis

    • Principal Investigator
      NODA Tetsuo
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Japanese Foundation For Cancer Research
  •  Functional analysis of Werner's helicase family by gene targeting

    • Principal Investigator
      SUGAWARA Minoru
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Genetics/Genome dynamics
    • Research Institution
      Tohoku University
  •  ウェルナーヘリケース遺伝子ファミリーの機能異常による発癌機構の解明

    • Principal Investigator
      菅原 稔
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  ウェルナーヘリケース遺伝子ファミリーの機能異常による発癌機構の解析

    • Principal Investigator
      菅原 稔
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Functional analysis of Werner's helicase family by gene targeting

    • Principal Investigator
      SUGAWARA Minoru
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      Tohoku UniverSity
  •  Development of Inducible Gene Targeting in MicePrincipal Investigator

    • Principal Investigator
      TAKANO Hiroshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Tohoku University
  •  Fuctinonal analysis of cancer related genes by targeted mutagenesis in mice

    • Principal Investigator
      NODA Tetsuo
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  ヘリケース機能異常による発癌機構の解析

    • Principal Investigator
      SUGAWARA Minoru
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University
  •  哺乳類中枢神経系の発生におけるPOU転写因子の機能

    • Principal Investigator
      美野輪 治
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Japanese Foundation For Cancer Research
  •  ジーンターゲティングによるPEBP遺伝子ファミリーの機能の解析

    • Principal Investigator
      美野輪 治
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Japanese Foundation For Cancer Research
  •  ジーンターゲティングによるヒト発癌機構の解析

    • Principal Investigator
      NODA Tetsuo
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University
      Japanese Foundation For Cancer Research
  •  ジーンターゲティングによるmgl遺伝子ファミリーの機能解析Principal Investigator

    • Principal Investigator
      高野 洋志
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cell biology
    • Research Institution
      Japanese Foundation For Cancer Research
  •  P1ファージ由来組換え酵素導入による条件依存性変異体マウスの作成

    • Principal Investigator
      美野輪 治
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Japanese Foundation For Cancer Research

All 2015 2014 2013 2009 2007 Other

All Journal Article Presentation

  • [Journal Article] Establishment of patient-derived cancer xenografts in immunodeficient NOG mice.2015

    • Author(s)
      Chijiwa T, Kawai K, Noguchi A, Sato H, Hayashi A, Cho H, Shiozawa M, Kishida T, Morinaga S, Yokose T, Katayama M, Takenaka N, Suemizu H, Yamada R, Nakamura Y, Ohtsu T, Takano Y, Imai K, Miyagi Y, Nakamura M
    • Journal Title

      International Journal of Oncology

      Volume: 47 Issue: 1 Pages: 61-70

    • DOI

      10.3892/ijo.2015.2997

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26430097, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04287, KAKENHI-PROJECT-25430098, KAKENHI-PROJECT-26640101
  • [Journal Article] Cell division cycle-associated protein 1 overexpression is essential for the malignant potential of colorectal cancers.2014

    • Author(s)
      Kobayashi Y, Takano A, Miyagi Y, Tsuchiya E, Sonoda H, Shimizu T, Okabe H, Tani T, Fujiyama Y, Daigo Y.
    • Journal Title

      International journal of oncology

      Volume: 44 Issue: 1 Pages: 69-77

    • DOI

      10.3892/ijo.2013.2177

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501341, KAKENHI-PROJECT-221S0001
  • [Journal Article] Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: Results from the SMART database.2014

    • Author(s)
      Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
    • Journal Title

      Mod Rheumatol

      Volume: 27 Issue: 2 Pages: 1-6

    • DOI

      10.3109/14397595.2014.950036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25861575, KAKENHI-PROJECT-15K10818, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101
  • [Journal Article] DSE-FRET : A new anticancer drug screening assay for DNA binding proteins2014

    • Author(s)
      Miyagi T, Shiotani B, Miyoshi R, Yamamoto T, Oka T, Umezawa K, Ochiya T, Takano M, Tahara H
    • Journal Title

      Cancer Sci

      Volume: (in press) Issue: 7 Pages: 870-874

    • DOI

      10.1111/cas.12420

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300363, KAKENHI-PROJECT-24650645, KAKENHI-PUBLICLY-25112711, KAKENHI-PROJECT-25701005, KAKENHI-PROJECT-26290047, KAKENHI-PROJECT-26310106, KAKENHI-PROJECT-26640091, KAKENHI-PROJECT-221S0001
  • [Journal Article] 5-Lipoxygenase and CysLT1 regulate EGF‐induced cell migration through Tiam1 upregulation and Rac1 activation.2014

    • Author(s)
      Magi S, Takemoto Y, Kobayashi H, Kasamatsu M, Akita T, Tanaka A, Takano K, Tashiro E, Igarashi Y, Imoto M.
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 3 Pages: 290-296

    • DOI

      10.1111/cas.12340

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23102006, KAKENHI-PROJECT-25560419, KAKENHI-PROJECT-26350974, KAKENHI-PROJECT-221S0001
  • [Journal Article] SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer.2014

    • Author(s)
      Noguchi A, Kikuchi K, Zheng H, Takahashi H, Miyagi Y, Aoki I, Takano Y.
    • Journal Title

      Cancer Med.

      Volume: 3 Issue: 6 Pages: 1553-61

    • DOI

      10.1002/cam4.310

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24593043, KAKENHI-PROJECT-25861990, KAKENHI-PROJECT-221S0001
  • [Journal Article] A Systematic Approach to the Development of Novel Therapeutics for Lung Cancer using Genomic Analyses.2013

    • Author(s)
      Daigo Y, Takano A, Teramoto K, Chung S, Nakamura Y.
    • Journal Title

      Clin Pharmacol Ther

      Volume: 94 Issue: 2 Pages: 218-223

    • DOI

      10.1038/clpt.2013.90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650624, KAKENHI-PROJECT-24390145, KAKENHI-PROJECT-24501341, KAKENHI-PROJECT-221S0001
  • [Journal Article] RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer.2013

    • Author(s)
      Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
    • Journal Title

      Mol Cancer Res

      Volume: 11 Issue: 8 Pages: 937-951

    • DOI

      10.1158/1541-7786.mcr-12-0685-t

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650624, KAKENHI-PROJECT-23659433, KAKENHI-PROJECT-24390145, KAKENHI-PROJECT-25253057, KAKENHI-PROJECT-221S0001
  • [Journal Article] Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo.2009

    • Author(s)
      H.Shibata, H.Yamakoshi, A.Sato, H.Ohori, Y.Kakudo, C.Kudo, Y.Takahashi, M.Watanabe, H.Takano, C.Ishioka, T.Noda, Y.Iwabuchi.
    • Journal Title

      Cancer Sci. 100(5)

      Pages: 956-960

    • NAID

      10025146044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013006
  • [Journal Article] Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo.2009

    • Author(s)
      H.Shibata, H.Takano, T.Noda, et.al.(Total 12, 9th/H.Takano, 11th/T.Noda)
    • Journal Title

      Cancer Sci.

      Volume: 100 Pages: 956-960

    • NAID

      10025146044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013006
  • [Journal Article] α-Catenin is essential in intestinal adenoma formation.2007

    • Author(s)
      H.Shibata, H.Takano, M.Ito, H.Shioya, M.Hirota, H.Matsumoto, Y.Kakudo, C.Ishioka, T.Akiyama, Y.Kanegae, I.Saito, T.Noda.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 104(46)

      Pages: 18199-18204

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013006
  • [Presentation] 消化管腫瘍形成におけるAPC1309の機能解析

    • Author(s)
      高野洋、八尾良司、野田哲生
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-221S0001
  • 1.  SUGAWARA Minoru (20311558)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 2.  NODA Tetsuo (10183550)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 3.  YAGINUMA Katsuyuki (40182307)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  美野輪 治 (00181967)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  YAO Ryoji (80291095)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  柴田 浩行 (50260071)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  IMAI Kohzoh (60117603)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  INOUE Junichiro (70176428)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NAKAMURA Takuro (00180373)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  ISHIKAWA Fuyuki (30184493)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YAMAMURA Kenichi (90115197)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ARAKI Kimi (90211705)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TAKAKURA Akira (60167484)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  KATOH Hideki (30142053)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  NAKAGATA Naomi (30159058)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  TOYOKUNI Shinya (90252460)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  WANIBUCHI Hideki (90220970)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  OGAWA Katsuhiro (50045514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  MITSUMORI Kunitoshi (10239296)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  YAMADA Yasuhiro (70313872)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  SHIBUTANI Makoto (20311392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  IMAIDA Katsumi (90160043)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  FUTAKUCHI Mitsuru (60275120)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  KANDA Hiroaki (90260067)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  TANAKA Hideo (60470168)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  WAKAI Kenji (50270989)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  MIKAMI Haruo (10332355)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  SUZUKI Sadao (20226509)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  MIURA Katsuyuki (90257452)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  WATANABE Yoshiyuki (00191809)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  ARISAWA Kokichi (30203384)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  TANAKA Keitaro (50217022)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  TAKEZAKI Toshiro (50227013)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  FURUSHO Norihiro (10346786)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  NAITO Mariko (10378010)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  OHNAKA Keizo (30325518)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  KITA Yoshikuni (30147524)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  KURIKI Kiyonori (20543705)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  TAMAKAOSHI Akiko (90236737)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  EGUCHI Hidetaka (00260232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  KUBO Michiaki (30442958)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  HAMAJIMA Nobuyuki (30172969)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  NAGATA Chisato (30283295)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  HINO Okio (90127910)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  TAHARA Hidetoshi (00271065)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 46.  SUGIMURA Haruhiko (00196742)
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  • 136.  野口 映
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  • 137.  菊地 慶司
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  • 138.  野口 誠
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