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Shimotohno Kunitada  下遠野 邦忠

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… Alternative Names

SHIMOTONO Kunitada  下遠野 邦忠

下遠野 忠邦  シモトオノ タダクニ

SHIMOTOHNO Kunitada  下遠野 邦忠

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Researcher Number 10000259
Other IDs
Affiliation (Current) 2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 特任研究員
Affiliation (based on the past Project Information) *help 2014: 国立国際医療研究センター, 肝炎・免疫研究センター, 特任部長
2013 – 2014: 独立行政法人国立国際医療研究センター, その他部局等, その他
2012: (独)国立国際医療研究センター, 肝炎免疫研究センター, 特任部長
2009 – 2011: Keio University, 附属総合研究所, 教授
2009: 千葉工業大学, 附属総合研究所 … More
2008: Chiba Institute of Technology, 附属総合研究所, 研究員
2008: 慶応義塾大学, 医学部, 教授
2007 – 2008: Keio University, 医学部, 教授
2007: 慶應義塾大学, 医学部・総合医科学研究センター, 教授
1997 – 2006: 京都大学, ウイルス研究所, 教授
2004: 京都大学, ウィルス研究所, 教授
2003: 京都大学, ウイルス研究所・がんウイルス部門, 教授
1998: 京都大学ウイルス研究所, がんウイルス部門, 教授
1993 – 1994: 国立がんセンター, ウイルス部(研), 部長
1993: 国立がんセンター研究所, 部長
1992: 国立がんセンター, 研究所, 部長
1991: 国立癌センター研究所, 部長
1990: Dept. Head, National Cancer Center Research Institute, 研究所, 部長
1989 – 1990: 国立がんセンター研究所, 部長
1987 – 1990: 国立がんセンター, ウイルス部, 部長
1986: 国立がんセ, その他, その他
1985: 国立がんセンター, その他, その他 Less
Review Section/Research Field
Principal Investigator
Virology / Virology / Biological Sciences / 代謝生物化学 / Biological Sciences
Except Principal Investigator
Virology / 遺伝学 / Biological Sciences / Gastroenterology / Biological Sciences / Virology / Gastroenterology
Keywords
Principal Investigator
C型肝炎ウイルス / Tax / ヒトT細胞白血病ウイルス / p53 / 複製 / 転写活性化 / アポトーシス / インターフェロン / アポリポ蛋白質 / CREB … More / apoptosis / hepatitis C virus / 転写 / LTR / ゲノム / 持続感染 / 脂肪症 / 脂肪代謝 / ウイルス複製 / 脂肪滴 / ATL / NFkB / transcription / p21 / Tat / p73 / replicon / TLR3 / レプリコン / trans-activation / human T-cell leukemia virus / p53関連遺伝子群 / コアクチベーター / がん抑制遺伝子 / エンハンサー / リポ蛋白質 / 感染 / 免疫 / 自然免疫 / 肝がん / サイクロフィリン / 抗ウイルス剤 / VLDL / HCV / 慢性肝炎 / サイクロスポリン / methylation / HTLV / p21^<WAF> / ATL(成人T細胞白血病) / NF-κB / HTLV-1(ヒトT細胞白血病ウイルス) / 成人T細胞白血病 / メチル化 / mmortalization / cvcline inhibitor / Human T-cell leukemia virus / トランスフォーム / replication / HCV genome / chronic hepatitis / 複製複合体 / リバビリン / RT-PCR / p53 related genes / サイクリン / TAX / コレプレッサー / nuclear receptor hormone / innate immunity / cyclophilin / genome / 小胞体膜 / NF-kB / コアタンパク質 / トランスジェニックマウス / NS5A / リン酸化 / PKR / 細胞増殖 / HCVゲノムレプリコン複製 / ウイルスポリメラーゼ / 核内受容体 / ウイルスゲノム / immortalization / co-activator / p53 gene family / suppressor oncogene / 転写抑制 / HTLV-1 / CBP / caspase activity / inflammation / mitochondria / HBx protein / NFkB siganling / hepatitis B virus / MHC / X蛋白質 / 細胞障害性T細胞 / 染色体不安定性 / B型肝炎ウイルス / 試験管内転写系 / 転写活性 / cDNA / X遺伝子 / 受容体 / LDLR / VLDLR / 低酸素環境 / アポリポ蛋白質E / VLDL受容体 / 癌 / 脂質 / 感染症 / ウイルス / NASH / APOBEC1 / chemokine / IL-lalpha / MIP1beta / 星細胞 / IL-8 / cytokine / Apobec1 / 悪性化 / アポベック / 悪性腫瘍 / サイトカイン / 発がん / 炎症 / 肝炎ウイルス / トリグリセリド / アポリポタンパク質 / 感染性 / 培養細胞 / RIGI / リガーゼ / ユビキチン / シクロフィリン / 感染性ウイルス / 脂肪肝 / 油滴 / リポタンパク質受容体 / リポタンパク質 / 肝組織の繊維化 / 肝発がん / アポリポタンパク質E / 複製阻害 … More
Except Principal Investigator
C型肝炎ウイルス / X遺伝子 / B型肝炎ウイルス / がん遺伝子 / RNAウイルス / がん遺伝子の協同作用 / エンハンサー / 転写調節 / トランスフォーム遺伝子 / トランス作用遺伝子 / 感染 / 癌 / 感染症 / 超可変領域 / 肝発がん / German-Japanese collaborative program in cancer research / French-Japanese collaborative programe in cancer research / Growth Factors / Cytokines / Tumor Suppressor Genes / Oncogenes / Human Gene Mapping / International Exchange Program / 増殖因子 / サイトカイン / 発がん / DNA修復 / ヒトがん遺伝子 / ヒトレトロウイルス / がん抑制遺伝子 / 感染阻止実験 / 分子進化 / ウイルス増殖抑制試験 / 合成ペプチド / ワクチン開発 / 外被糖タンパク / HIV / AIDS / envペプチド / 結晶解析 / ウイルス増殖抑制 / 中和試験 / 分子進化学 / 合成ワクチン / AIDSウイルス / トランス型遺伝子調節 / トランス型遺伝子活性化 / シグナル伝達 / 細菌 / ドラッグデリバリー / 免疫 / 炎症 / 感染がん / がん / 発がんスパイラル / 炎症・免疫 / マイクロアレイ / HCV / 慢性C型肝炎 / マイクロRNA / ウィルス / 細胞組織 / 遺伝子 / 細胞・組織 / ゲノム / ウイルス / 遺伝学 / 植物ウイルス / ピコルナウイルス / モノネガウイルス / インフルエンザウイルス / シンポジウム / 分子生物学 / 病原性 / レセプター / Fusion / 遺伝子操作 / 宿主因子 / 細胞内情報伝達機構 / インターフェロン / 肝細胞癌 / 免疫応答 / 肝炎ウイルス増殖機構 / 肝炎ウイルス遺伝子変異 / HLA / 変異株 / B型肝炎 / 中和抗体 / SSCP / C型肝炎 / 超可変領域(HVR) / 持続感染 / セリンプロテアーゼインヒビター / トランス活性化 / C型肝炎ウイルス(HCV) / B型肝炎ウイルス(HBV) / 前駆体蛋白質プロセッシング / プロテアーゼインヒビター / 転写活性化 / ウイルス性肝発がん / C100ー3抗体 / HCVRNA / 肝がん / 慢性肝炎 / HTLVーIキャリア / 母子感染 / 転写活性化因子 / p40^<tax> / ATL / HTLVーI / 11番染色体の変化 / サザンブロット / 肝癌 / 致死的再編成 / 宿主染色体の再編成 / 感染細胞系 / 組込み Less
  • Research Projects

    (31 results)
  • Research Products

    (148 results)
  • Co-Researchers

    (86 People)
  •  Infection/inflammation-assisted acceleration of the carcinogenic spiral and its alteration though vector conversion of the host response to tumors

    • Principal Investigator
      HATAKEYAMA Masanori
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Prevention of cancer development by hepatitis C virusPrincipal Investigator

    • Principal Investigator
      SHIMOTOHNO Kunitada
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Research Institute, International Medical Center of Japan
      Chiba Institute of Technology
  •  The role of lipid metabolism on HCV proliferationPrincipal Investigator

    • Principal Investigator
      SHIMOTOHNO Kunitada
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Virology
    • Research Institution
      Research Institute, International Medical Center of Japan
      Chiba Institute of Technology
  •  Roles of lipid in HCV productionPrincipal Investigator

    • Principal Investigator
      SHIMOTOHNO Kunitada
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Chiba Institute of Technology
  •  Trial for the novel therapy of chronic hepatitis C by using platform of the RNAi machinery

    • Principal Investigator
      MURAKAMI Yoshiki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kyoto University
  •  インターフェロンに抵抗性を示すC型肝炎ウイルスの複製戦略の解明Principal Investigator

    • Principal Investigator
      下遠野 邦忠
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Virology
    • Research Institution
      Keio University
  •  Development of preventive measures of liver failures caused by HCV infection by clarification of the mechanisms of liver diseasesPrincipal Investigator

    • Principal Investigator
      SHIMOTOHNO Kunitada
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
      Kyoto University
  •  Genetic and Epigenetic Dysregulation in Cancer

    • Principal Investigator
      NODA Tetsuo
    • Project Period (FY)
      2004 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Japanese Foundation For Cancer Research
      Tohoku University
  •  The roles of Tax encoded by HTLV on cell proliferationPrincipal Investigator

    • Principal Investigator
      SHIMOTOHNO Kunitada
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      KYOTO UNIVERSITY
  •  RNAウイルス研究の新展開

    • Principal Investigator
      伊藤 康彦
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Mie University
  •  Transcriptional Regulation and Cell Immortalization in human T-cell leukemia virus type 1 encoded by TaxPrincipal Investigator

    • Principal Investigator
      SHIRNOTOHNO Kunitada
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      KYOTO UNIVERSITY
  •  On the development of the system to screen new anti-HCV drugsPrincipal Investigator

    • Principal Investigator
      SHIMOTOHNO Kunitada
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      KYOTO UNIVERSITY
  •  Preventive measure of the development of hepatocellular carcinoma by hepatitis C virus infectionPrincipal Investigator

    • Principal Investigator
      SHIMOTOHNO Kunitada
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Clarification of mechanism of HTLV-1 Tax protein on cell immortalization.Principal Investigator

    • Principal Investigator
      SHIMOTOHNO Kunitada
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Kyoto University
  •  RNAウイルス研究の最前線

    • Principal Investigator
      榎並 正芳
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Kanazawa University
  •  RNAウイルス研究の新展開

    • Principal Investigator
      伊藤 康彦
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Mie University
  •  Clarification of molecular mechanisims of hepatocellular carcinoma caused by hepatitis virus infection.Principal Investigator

    • Principal Investigator
      SHIMOTOHNO Kunitada
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Institute for Virus Research, Kyoto University
  •  Clarification of reguratory mechanism of cell proliferation by HTLV-1.Principal Investigator

    • Principal Investigator
      SHIMOTOHNO Kunitada
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      KYOTO UNIVERSITY
  •  肝炎ウイルス制圧へ向けての包括的研究

    • Principal Investigator
      小俣 政男
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  遺伝子工学的アプローチによるウイルス性肝病態進展の予測と治療法の開発

    • Principal Investigator
      小俣 政男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Institution
      The University of Tokyo
  •  肝炎ウイルスと肝発がん

    • Principal Investigator
      KOIKE Katsurou
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research
  •  肝炎ウイルスと肝発がん

    • Principal Investigator
      小池 克郎
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research
  •  肝炎ウイルスと肝発がん

    • Principal Investigator
      小池 克郎
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research
  •  成人T細胞白血病と病因ウイルス

    • Principal Investigator
      菅村 和夫
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tohoku University
  •  B型肝炎ウイルスの増殖・組込みと肝癌発生との関連

    • Principal Investigator
      松原 謙一
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  Trans-acting遺伝子の機能と細胞のがん化

    • Principal Investigator
      藤永 〓
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  AIDSウィルス合成ワクチンのための総合的方法論を目指した試験的研究

    • Principal Investigator
      五條堀 孝
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      遺伝学
    • Research Institution
      National Institute of Genetics
  •  Cooperation and Information Exchange with European Countries

    • Principal Investigator
      KUROKI Toshio
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Institute of Medical Science, University of Tokyo
  •  Transーacting遺伝子の機能と細胞のがん化

    • Principal Investigator
      藤永 薫
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  ヒト白血病ウイルスプロウイルスDNAの試験管内における転写系の確立Principal Investigator

    • Principal Investigator
      下遠野 邦忠
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      代謝生物化学
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  ヒト白血病ウイルスに存在する遺伝子(X)の構造と発現Principal Investigator

    • Principal Investigator
      下遠野 邦忠
    • Project Period (FY)
      1985
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Other

All Journal Article Presentation Book Patent

  • [Book] 腫瘍ウイルス(肝炎ウイルス) がん生物学イラストレイテッド2011

    • Author(s)
      宇治野真之, 杉山和夫, 下遠野邦忠
    • Publisher
      羊土社 東京
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Book] 肝胆膵(アークメディア)2011

    • Author(s)
      日紫喜隆行、清水裕子、宇治野真之、下遠野邦忠
    • Publisher
      HCV形成の場としての脂肪滴の役割と粒子放出
    • Data Source
      KAKENHI-PLANNED-22114004
  • [Book] 肝胆膵(アークメディア)2011

    • Author(s)
      日紫喜隆行、清水裕子、宇治野真之、下遠野邦忠
    • Publisher
      HCV形成の場としての脂肪滴の役割と粒子放出
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Book] C型肝炎ウイルスと肝発がんに関する研究2010

    • Author(s)
      下遠野邦忠
    • Publisher
      自然科学社
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Book] C型肝炎ウイルス研究の新知見 医学のあゆみ2010

    • Author(s)
      下遠野 邦忠
    • Publisher
      医歯薬出版株式会社 東京
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Book] HCV複製のメカニズム」Medical Practice2010

    • Author(s)
      下遠野邦忠
    • Publisher
      文光社
    • Data Source
      KAKENHI-PROJECT-20390135
  • [Book] Medical Practice(HCV複製のメカニズム)2010

    • Author(s)
      下遠野邦忠
    • Publisher
      文光社
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Book] 化学と生物(c型肝炎ウルイスの生活環と発がん)2008

    • Author(s)
      宮成悠介、臼田信光、土方誠、下遠野邦忠
    • Publisher
      日本農芸学会
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Book] 蛋白質核酸酵素(c型肝炎ウイルスの増殖戦略)2008

    • Author(s)
      宮成悠介、臼田信光、下遠野邦忠
    • Publisher
      共立出版株式会社
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Book] 蛋白質核酸酵素2008

    • Author(s)
      宮成悠介、臼田信光、下遠野邦忠
    • Publisher
      共立出版株式会社
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] The J6JFH1 Strain of Hepatitis C Virus Infects Human B-Cells with Low Replication Efficacy.2014

    • Author(s)
      Nakai M, Seya T, Matsumoto M, Shimotohno K, Sakamoto N, Aly HH.
    • Journal Title

      Viral Immunol.

      Volume: 27 Issue: 6 Pages: 285-294

    • DOI

      10.1089/vim.2013.0140

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-26670375
  • [Journal Article] Critical role of interferon-α constitutively produced in human hepatocytes in response to RNA virus infection2014

    • Author(s)
      Tsugawa Y, Kato H, Fujita T, Shimotohno K, Hijikata M
    • Journal Title

      PLoS One

      Volume: 9(2)

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] The J6JFH1 Strain of Hepatitis C Virus Infects Human B-Cells with Low Replication Efficacy2014

    • Author(s)
      Nakai M, Seya T, Matsumoto M, Shimotohno K, Sakamoto N, Aly HH
    • Journal Title

      Viral Immunol

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles.2014

    • Author(s)
      Arimoto KI, Hishiki T, Kiyonari H, Abe T, Cheng C, Yan M, Fan JB, Futakuchi M, Tsuda H, Murakami Y, Suzuki H, Zhang DE, Shimotohno K
    • Journal Title

      J Interferon Cytokine Res.

      Volume: 35 Issue: 5 Pages: 351-358

    • DOI

      10.1089/jir.2014.0113

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-24501319, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15K06837, KAKENHI-PROJECT-15K19109
  • [Journal Article] Critical role of interferon-α constitutively produced in human hepatocytes in response to RNA virus infection.2014

    • Author(s)
      Tsugawa Y, Kato H, Fujita T, Shimotohno K, Hijikata M.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 2 Pages: e89869-e89869

    • DOI

      10.1371/journal.pone.0089869

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-24659205
  • [Journal Article] The RNA-editing enzyme APOBEC1 requires heterogeneous nuclear ribonucleoprotein Q isoform 6 for efficient interaction with interleukin-8 mRNA.2014

    • Author(s)
      Shimizu Y, Nishitsuji H, Marusawa H, Ujino S, Takaku H, Shimotohno K.
    • Journal Title

      J Biol Chem.

      Volume: 289 Issue: 38 Pages: 26226-26238

    • DOI

      10.1074/jbc.m114.563221

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-24229005, KAKENHI-PROJECT-24590557
  • [Journal Article] Thromboxane A2 Synthase Inhibitors Prevent Production of Infectious Hepatitis C Virus in Mice With Humanized Livers2013

    • Author(s)
      Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chayama K, Hijikata M
    • Journal Title

      Gastroenterology

      Volume: 145 Pages: 658-667

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] PML tumor suppressor protein is required for HCV production2013

    • Author(s)
      Kuroki M, Ariumi Y, Hijikata M, Ikeda M, Dansako H, Wakita T, Shimotohno K, Kato N.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 430(2) Pages: 592-597

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Hepatitis C Virus Infection Induces Inflammatory Cytokines and Chemokines Mediated by the Cross Talk between Hepatocytes and Stellate Cells2013

    • Author(s)
      Nishitsuji H, Funami K, Shimizu Y, Ujino S, Sugiyama K, Seya T, Takaku H, Shimotohno K
    • Journal Title

      J. Viol

      Volume: 87 Pages: 8169-8178

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Thromboxane A2 Synthase Inhibitors Prevent Production of Infectious Hepatitis C Virus in Mice with Humanized Livers.2013

    • Author(s)
      Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chavama K, Hijikata M.
    • Journal Title

      Gastroenterology

      Volume: 145 Issue: 3 Pages: 658-667

    • DOI

      10.1053/j.gastro.2013.05.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J03908, KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-22249012, KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-25670369
  • [Journal Article] Hepatitis C Virus Infection Induces Inflammatory Cytokines and Chemokines Mediated by the Cross Talk between Hepatocytes and Stellate Cells.2013

    • Author(s)
      Nishitsuji H, Funami K, Shimizu Y, Ujino S, Sugiyama K, Seya T, Takaku H, Shimotohno K.
    • Journal Title

      J. Viol

      Volume: 87 Issue: 14 Pages: 8169-8178

    • DOI

      10.1128/jvi.00974-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22114004, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-22249012, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-24590993, KAKENHI-PROJECT-24659214
  • [Journal Article] PML tumor suppressor protein is required for HCV production2013

    • Author(s)
      Kuroki M, Ariumi y, Hi j i ka ta M, Ikeda M, Dansnko H, Wakita T, Shimotohno K, Kato N
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 430 Issue: 2 Pages: 592-597

    • DOI

      10.1016/j.bbrc.2012.11.108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J03053, KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-23590544, KAKENHI-PROJECT-23590545
  • [Journal Article] Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis2012

    • Author(s)
      Hirata Y, Ikeda K, shimotohno K, et al.,
    • Journal Title

      PLoS Pathog

      Volume: PLoS Pathog Issue: 8 Pages: e1002860-e1002860

    • DOI

      10.1371/journal.ppat.1002860

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-23659238, KAKENHI-PROJECT-24390117, KAKENHI-PROJECT-24619007, KAKENHI-PROJECT-24710231, KAKENHI-PLANNED-22134007
  • [Journal Article] Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis2012

    • Author(s)
      Hirata Y, Ikeda K, Sudoh M, Tokunaga Y, Suzuki A, Weng L, Ohta M, Tobita Y, Okano Ozeki K, Kawasaki K, Tsukuda T, Katsume A, Aoki Y, Umehara T, Sekiguchi S, Toyoda T, Shimotohno K, Soga T, Nishijima M, Taguchi R, Kohara M
    • Journal Title

      PLoS Pathog

      Volume: 8(8)

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro2012

    • Author(s)
      Weng L, Tian X, Gao Y, Watashi K, Shimotohno K, Wakita T, Kohara M, Toyoda T
    • Journal Title

      Biochim Biophys Acta

      Volume: 1820(12) Pages: 1886-1892

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] In vitro models for analysis of the hepatitis C virus life cycle2012

    • Author(s)
      Aly HH, Shimotohno K, Hijikata M, Seya T
    • Journal Title

      Microbiol Immunol

      Volume: 56(1) Pages: 1-9

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase2012

    • Author(s)
      Weng L, Kohara M, Wakita T, Shimotohno K, Toyoda T
    • Journal Title

      Gene

      Volume: 496 Issue: 2 Pages: 79-87

    • DOI

      10.1016/j.gene.2012.01.044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249012, KAKENHI-PROJECT-23659407
  • [Journal Article] The interaction between human initiation factor eIF3 subunit c and heat-shock protein 90 : a necessary factor for translation mediated by the hepatitis C virus internal ribosome entry site2012

    • Author(s)
      Ujino S, Nishitsuji H, Sugiyama R, Suzuki H, Hishiki T, Sugiyama K, Shimotohno K, Takaku H
    • Journal Title

      Virus Res

      Volume: 163(1) Pages: 390-395

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] In vitro models for the analysis of HCV life cycle2011

    • Author(s)
      Aly HH, Shimotohno K, Hijikata M, Seya T
    • Journal Title

      Microbiol Immunol

      Volume: 56 Issue: 1 Pages: 1-9

    • DOI

      10.1111/j.1348-0421.2011.00403.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-22249012, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-24659214
  • [Journal Article] Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B2011

    • Author(s)
      Morohashi K, Sahara H, Watashi K, Iwabata K, Sunoki T, Kuramochi K, Takakusagi K, Miyashita H, Sato N, Tanabe A, Shimotohno K, Kobayashi S, Sakaguchi K, Sugawara F
    • Journal Title

      PLoS One

      Volume: 6(4)

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] The Progression of Liver Fibrosis Is Related with Overexpression of the miR-199 and 200 Families.2011

    • Author(s)
      Shimotohno K (Murakami Y)
    • Journal Title

      PLoS One

      Volume: 6

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22114004
  • [Journal Article] Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro2011

    • Author(s)
      Weng L, Tian X, shimotohno K, et al.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1820 Issue: 12 Pages: 1886-1892

    • DOI

      10.1016/j.bbagen.2012.08.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249012, KAKENHI-PROJECT-23659238, KAKENHI-PROJECT-24390117, KAKENHI-PUBLICLY-23114511, KAKENHI-PUBLICLY-24102537
  • [Journal Article] Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms2011

    • Author(s)
      Hishiki T, Shimizu Y, Tobita R, Sugiyama K, Ogawa K, Funami K, Ohsaki Y, Fujimoto T, Takaku H, Wakita T, Baumert TF, Miyanari Y, Shimotohno K
    • Journal Title

      J Virol

      Volume: 84(22) Pages: 12048-12057

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Lipoprotein lipase and hepatic triglyceride lipase reduce the infectivity of hepatitis C virus (HCV) through their catalytic activities on HCV-associated lipoproteins2011

    • Author(s)
      Shimizu Y, Hishiki T, Sugiyama K, Ogawa K, Funami K, Kato A, Ohsaki Y, Fujimoto T, Takaku H, Shimotohno K
    • Journal Title

      Virology

      Volume: 407(1) Pages: 152-915

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Lipoprotein components associated with hepatitis C virus is essential for virus infectivity2011

    • Author(s)
      Shimizu Y, Hishiki T, Ujino S, Sugiyama K, Funmi K, Shimotohno K
    • Journal Title

      Current Opinion in Virology

      Volume: 1 Pages: 19-26

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Development of mouse hepatocyte lines permissive for hepatitis C virus (HCV)2011

    • Author(s)
      Aly HH, Oshiumi H, Shime H, Matsumoto M, Wakita T, Shimotohno K, Seya T
    • Journal Title

      PLoS One

      Volume: 6(6)

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Dysregulation of IFN system can lead to poor response to pegylated interferon and ribavirin therapy in chronic hepatitis C2011

    • Author(s)
      Onomoto K, Morimoto S, Kawaguchi T, Toyoda H, Tanaka M, Kuroda M, Uno K, Kumada T, Matsuda F, Shimotohno K, Fujita T, Murakami Y
    • Journal Title

      PLoS ONE

      Volume: 6 Issue: 5 Pages: e19799-e19799

    • DOI

      10.1371/journal.pone.0019799

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-23659626, KAKENHI-PROJECT-23890029
  • [Journal Article] The Progression of Liver Fibrosis Is Related with Overexpression of the miR-199 and 200 Families2011

    • Author(s)
      Murakami Y, Toyoda H, Tanaka M, Kuroda M, Harada Y, Matsuda F, Tajima A, Kosaka N, Ochiya T, Shimotohno K
    • Journal Title

      PLoS One

      Volume: 6(1)

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Lipoprotein components associated with hepatitis C virus is essential for virus infectivity2011

    • Author(s)
      Ujino S, Nishitsuji H, Sugiyama R, Suzuki H, Hishiki T, Sugiyama K, Shimotohno K, Takaku H
    • Journal Title

      Virus Res

      Volume: 163 Issue: 1 Pages: 390-395

    • DOI

      10.1016/j.virusres.2011.10.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-22249012
  • [Journal Article] Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B2011

    • Author(s)
      Morohashi K, Sahara H, Watashi K, Iwabata K, Sunoki T, Kuramochi K, Takakusagi K, Miyashita H, Sato N, Tanabe A, Shimotohno K, Kobayashi S, Sakaguchi K, Sugawara F
    • Journal Title

      PLoS ONE

      Volume: 6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Dysregulation of IFN system can lead to poor response to pegylated interferon and ribavirin therapy in chronic hepatitis C2011

    • Author(s)
      Onomoto K, Morimoto S, Kawaguchi T, Toyoda H, Tanaka M, Kuroda M, Uno K, Kumada T, Matsuda F, Shimotohno K, Fujita T, Murakami Y
    • Journal Title

      PLoS One

      Volume: 6(5)

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Lipoprotein lipase and hepatic triglyceride lipase reduce the infectivity of hepatitis C virus(HCV)through their catalytic activities on HCV-associated lipoproteins.2010

    • Author(s)
      Shimotohno K(Shimizu Y)
    • Journal Title

      Virology

      Volume: 152 Pages: 152-915

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article]2010

    • Author(s)
      下遠野邦忠
    • Journal Title

      HCV複製のメカニズム(文光堂)

      Pages: 107-109

    • Data Source
      KAKENHI-PROJECT-20390135
  • [Journal Article] Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C2010

    • Author(s)
      Murakami Y, Tanaka M, Toyoda H, Hayashi K, Kuroda M, Tajima A, Shimotohno K
    • Journal Title

      BMC Med Genomics

      Volume: 3(1) Pages: 48-48

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Combination therapy for hepatitis C virus with heat-shock protein 90 inhibitor 17-AAG and proteasome inhibitor MG1322010

    • Author(s)
      Ujino S, Yamaguchi S, Shimotohno K, Takaku H
    • Journal Title

      Antivir Chem Chemother

      Volume: 20(4) Pages: 161-167

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner2010

    • Author(s)
      Shimotohno K(Weng L)
    • Journal Title

      J.Virology

      Volume: 84 Pages: 11761-11770

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Hepatic microRNA expression is associated with the response to interfer on treatment of chronic hepatitis C2010

    • Author(s)
      Shimotohno K(Murakami Y)
    • Journal Title

      BMC Med Genomics

      Volume: 3 Pages: 48-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms.2010

    • Author(s)
      Shimotohno K (Hishiki T)
    • Journal Title

      J.Virology

      Volume: 84 Pages: 12048-12057

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22114004
  • [Journal Article] Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner2010

    • Author(s)
      Weng L, Hirata Y, Arai M, Kohara M, Wakita T, Watashi K, Shimotohno K, He Y, Zhong J, Toyoda T
    • Journal Title

      J Virol

      Volume: 84(22) Pages: 11761-11770

    • Data Source
      KAKENHI-PROJECT-22249012
  • [Journal Article] Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.2010

    • Author(s)
      Shimotohno K (Oshiumi H)
    • Journal Title

      PLoS One

      Volume: 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22114004
  • [Journal Article] Hijikata Strain-dependent viral dynamics and virus-cell interactions in a novel in vitro system supporting the life cycle of blood-borne hepatitis C virus.2009

    • Author(s)
      HH. Aly, Y. Qi, K. Atsuzawa, N. Usuda, Y. Takada, M. Mizokami, K. Shimotohno, M.
    • Journal Title

      Hepatology 50(3)

      Pages: 689-696

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Baba M Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560.2009

    • Author(s)
      M. Okamoto, M. Sakai, Y. Goto, MT. Salim, C. Baba, K. Goto, K. Watashi, K. Shimotohno
    • Journal Title

      Antivir Chem Chemother 20(1)

      Pages: 47-54

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Hepatitis C virus utilizes lipid droplet for production of infectious virus2009

    • Author(s)
      K. Ogawa, T. Hishiki, Y. Shimizu, K. Funami, K. Sugiyama, Y. Miyanari, K. Shimotohno
    • Journal Title

      Proc Jpn Acad Ser B Phys Biol Sci. 85(7)

      Pages: 217-28

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Identification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor.2009

    • Author(s)
      K. Goto, K. Watashi, D. Inoue, M. Hijikata, K. Shimotohno
    • Journal Title

      Cancer Sci. 100(10)

      Pages: 1943-1950

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Novel approach for HCV regulation by miR-199a2009

    • Author(s)
      Murakami Y, Ali HH, Tajima A, Inoue I, and Shimotohno K
    • Journal Title

      Journal of Hepatology 50

      Pages: 453-460

    • Data Source
      KAKENHI-PROJECT-19590760
  • [Journal Article] Hepatitis C virus utilizes lipid droplet for production of infectious virus2009

    • Author(s)
      Ogawa K, Hishiki T, Shimizu Y, Funami K, Sugiyama K, Miyanari Y, Shimotohno K.
    • Journal Title

      Proc Jpn Acad Ser B Phys Biol Sci 85

      Pages: 217-228

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] 3D cultured immortalized human hepatocytes useful to develop drugs for blood-borne HCV2009

    • Author(s)
      Aly HH, Shimotohno K, Hijikata M
    • Journal Title

      Biochem Biophys Res Commun 379(2)

      Pages: 330-334

    • Data Source
      KAKENHI-PROJECT-19590760
  • [Journal Article] Identification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor2009

    • Author(s)
      Goto K, Watashi K, Inoue D, Hijikata M, Shimotohno K
    • Journal Title

      Cancer Sci. 100

      Pages: 1943-1950

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Regulation of the hepatitis C virus genome replication by miR-199 a(*).2009

    • Author(s)
      Murakami Y, Aly HH, Tajima A, Inoue I, Shimotohno K
    • Journal Title

      J Hepatol. 50

      Pages: 453-460

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390135
  • [Journal Article] 3D cultured immortalized human hepatocytes useful to develop drugs for blood-borne HCV.2009

    • Author(s)
      Aly HH, Shimotohno K, Hijikata M.
    • Journal Title

      Biochem Biophys Res Commun 379(2)

      Pages: 330-334

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390135
  • [Journal Article] Heat-shock protein 90 is essential for stabilization of the hepatitis C virus non-structural protein NS3.2009

    • Author(s)
      S.Ujino, S.Yamaguchi, K.Shimotohno, H.Takaku
    • Journal Title

      J.Biological Chemistry 284

      Pages: 6841-6846

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] 3D cultured immortalized human hepatocytes useful to develop drugs for blood-borne HCV2009

    • Author(s)
      Aly HH, Shimotohno K, Hijikata M.
    • Journal Title

      Biochem Biophys Res Commun 379

      Pages: 330-334

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390135
  • [Journal Article] Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents2008

    • Author(s)
      M. Ikejiri, T. Ohshima, A. Fukushima, K. Shimotohno, T. Maruyama
    • Journal Title

      Bioorg Med Chem Lett. 18(16)

      Pages: 4638-4641

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination2008

    • Author(s)
      O. Isono, T. Ohshima, Y. Saeki, J. Matsumoto, M. Hijikata, K. Tanaka, K. Shimotohno
    • Journal Title

      J Biol Chem. 283(49)

      Pages: 34273-34282

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p3002008

    • Author(s)
      J. Zhang, O. Yamada, K. Kawagishi, H. Araki, S. Yamaoka, T. Hattori, K. Shimotohno
    • Journal Title

      Virology 379(2)

      Pages: 306-313

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.2008

    • Author(s)
      Ikejiri M, Ohshima T, Fukushima A, Shimotohno K, Maruyama T.
    • Journal Title

      Bioorg Med Chem Lett 18(16)

      Pages: 4638-4641

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390135
  • [Journal Article] Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p3002008

    • Author(s)
      Zhang J, Yamada O, Kawagishi K, Araki H, Yamaoka S, Hattori T, Shimotohno K
    • Journal Title

      Virology 379(2)

      Pages: 306-313

    • Data Source
      KAKENHI-PROJECT-19590760
  • [Journal Article] Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents2008

    • Author(s)
      Ikejiri M, Ohshima T, Fukushima A, Shimotohno K, Maruyama T
    • Journal Title

      Bioorg Med Chem Lett 18

      Pages: 4638-4641

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Isolation and gene analysis of interferon alpha-resistant cell clones of the hepatitis C virus subgenome2008

    • Author(s)
      Noguchi T, Otsubaki T, Ando I, Ogura N, Ikeda S, Shimotohno K
    • Journal Title

      Virology 375

      Pages: 424-432

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Regulation of the hepatitis C virus genome replication by miR-199a(*)2008

    • Author(s)
      Murakami Y, Aly HH, Tajima A, Inoue I. Shimotohno K
    • Journal Title

      J Hepatol 50

      Pages: 453-460

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Human T-cell leukemia Virus type 1 HBZ protein bypasses the targeting function of ubiquitination2008

    • Author(s)
      Isono O, Ohshima T, Saeki Y, Matsumoto J, Hijikata M, Tanaka K, Shimotohno K
    • Journal Title

      J Biol Chem 283(49)

      Pages: 34273-34282

    • Data Source
      KAKENHI-PROJECT-19590760
  • [Journal Article] Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300.2008

    • Author(s)
      Zhang J, Yamada O, Kawagishi K, Araki H, Yamaoka S, Hattori T, Shimotohno K.
    • Journal Title

      Virology 379(2)

      Pages: 306-313

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390135
  • [Journal Article] Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents2008

    • Author(s)
      Ikejiri M, Ohshima T, Fukushima A, Shimotohno K, Maruyama T
    • Journal Title

      Bioorg Med Chem Lett 18(16)

      Pages: 4638-4641

    • Data Source
      KAKENHI-PROJECT-19590760
  • [Journal Article] Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination.2008

    • Author(s)
      Isono O, Ohshima T, Saeki Y, Matsumoto J, Hijikata M, Tanaka K, Shimotohno K.
    • Journal Title

      J Biol Chem 283(49)

      Pages: 34273-34282

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390135
  • [Journal Article] UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I2007

    • Author(s)
      Arimoto K, Konishi H, Shimotohno K.
    • Journal Title

      Mol Immunol 45

      Pages: 1078-1084

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659117
  • [Journal Article] Identification of new immunogenic peptides in conserved regions of hepatitis C virus (HCV) 1b with the potentiality to generate cytotoxic T lymphocytes in HCV1b(+) HLA-A24(+) patients2007

    • Author(s)
      Y. Takao, A. Yamada, S. Yutani, H, Ono T. Takedatsu, K. Etoh, Y. Wang, S. Suzuki, T. Ide, K. Shimotohno, M. Sata, K. Itoh
    • Journal Title

      Hepatol Res. 37(3)

      Pages: 186-195

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] The lipid droplet is an important organelle for hapatitis C virus production2007

    • Author(s)
      Miyanari Y, Atsuzawa K, Usuda N, Watashi K, Hishiki T, Zayas M, Bartenschlager R, Wakita T, Hijikata M, Shimotohno K.
    • Journal Title

      Nat Cell Biol 9(9)

      Pages: 1089-9710

    • Data Source
      KAKENHI-PROJECT-19590760
  • [Journal Article] The lipid droplet is an important organelle for hepatitis Cvirus production.2007

    • Author(s)
      Y. Miyanari, K. Shimotohno, et. al. (total 10, last)
    • Journal Title

      Nat. Cell Biol. 9

      Pages: 1089-9710

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Serum-derived hepatitis C virus infectivity in interferon regulatory factor-7-suppressed human primary hepatocytes2007

    • Author(s)
      Aly HH, Watashi K, Hijikata M, Kaneko H, Takada Y, Egawa H, uemoto S, Shimotohno K
    • Journal Title

      J Hepatol 46(1)

      Pages: 26-36

    • Data Source
      KAKENHI-PROJECT-19590760
  • [Journal Article] Helper virus-independent trans-replication of hepatitis C virus-derived minigenome2007

    • Author(s)
      J. Zhang, O. Yamada, H. Yoshida, T. Sakamoto, H. Araki, K. Shimotohno
    • Journal Title

      Biochem Biophys Res Commun. 352(1)

      Pages: 170-176

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Seram-derived hepatitis C virus infectivify in interferon regulatory factor-7-suppressed human primary hepatocytes2007

    • Author(s)
      Aly HH, Watashi K, Hijikata M, Kaneko H, Takada y EgawaH, Uemoto S, Shimotohno K
    • Journal Title

      J Hepatol 46

      Pages: 26-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] The lipid droplet is an important organelle for hepatitis Cvirus production2007

    • Author(s)
      Y. Miyanri, K. Atsuzawa, N. Usuda, K. Watashi, T. Hishiki, M. Zayas, R. Bartenschlager, T. Wakita, M. Hijikata, K. Shimotohno
    • Journal Title

      Nat. Cell Biol. 9

      Pages: 1089-1097

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Anti-hepatitis C virus activity of tamoxifen reveals the functional association of estrogen receptor with viral RNA polymerase NS5B2007

    • Author(s)
      Watashi K, Inoue D, Hijikata M, Goto K, Aly HH, ShimotohnoK.
    • Journal Title

      J Biol Chem. 282

      Pages: 32765-32772

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Chemical genetics approach to hepatitis C virus replication : cyclophilin as a target for anti-hepatitis C virus strategy2007

    • Author(s)
      Watashi K, Shimotohno K
    • Journal Title

      Rev Med Virol 17

      Pages: 245-252

    • Data Source
      KAKENHI-PROJECT-19590760
  • [Journal Article] In vitro infection of immortalized primary hepatocytes by HCV genotype 4a and inhibition of virus replication by cyclosporin2007

    • Author(s)
      MA. El-Farrash, HH. Aly, K. Watashi, M. Hijikata, H. Egawa, K. Shimotohno
    • Journal Title

      Microbiol Immunol 251(1)

      Pages: 127-133

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] In vitro infection of immortalized primary hepatocytes by HCV genotype 4a and inhibition of virus replication by cyclosporin2007

    • Author(s)
      El-Farrash MA, aly HH, Watashi K, Hijikata M, Egawa H, Shimotohno K
    • Journal Title

      Microbiol Immunol 51(1)

      Pages: 127-133

    • Data Source
      KAKENHI-PROJECT-19590760
  • [Journal Article] Negative regulation of the RIG-I signaling by the novel ubiquitin ligase RNF1252007

    • Author(s)
      K. Arimoto, H. Takahashi, T. Hishiki・, H. Konishi, T. Fujita, K. Shimotohno
    • Journal Title

      Proc. Natl. Acd. Sci. USA 104

      Pages: 7500-7505

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Helper virus-independent trans-replication of hepatitis C virus-derived minigenome2007

    • Author(s)
      Zhang J, Yamada O, Yoshida H, Sakamoto T, Araki H, Shimotohno K
    • Journal Title

      Biochem Biophys Res Commun 352(1)

      Pages: 170-176

    • Data Source
      KAKENHI-PROJECT-19590760
  • [Journal Article] Anti-hepatitis C virus activity of tamoxifen reveals the functional association of estrogen receptor with viral RNA polymerase NS5B2007

    • Author(s)
      Watashi K, Inoue D, Hijikata M, Goto K, Aly HH, Shimotohno K
    • Journal Title

      J Biol Chem 282(45)

      Pages: 32765-32772

    • Data Source
      KAKENHI-PROJECT-19590760
  • [Journal Article] The lipid droplet is an important organelle for hepatitis C virus produc2007

    • Author(s)
      Miyanari Y, Atsuzawa K, UsudaN, Watashi K, Hishiki T, Zayas M, Bartenschlager R, WakitaT, Hijikata M, Shimotohno K.
    • Journal Title

      Nat Cell Biol. 9

      Pages: 1089-1097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Negative regulation of the RIG-I signaling by the novel ubiquitin ligase RNF1252007

    • Author(s)
      Arimoto K, Takahashi H, Hishiki T, Konishi H, Fujita T, Shimotohno K
    • Journal Title

      Proc.Natl.Acd.Sci.USA 99

      Pages: 7500-7507

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659117
  • [Journal Article] Biochem Biophys Res Commun2006

    • Author(s)
      K. Goto, K Watashi, T. Murata, T. Hishiki, M. Hijikata, K. Shimotohno
    • Journal Title

      343(3)

      Pages: 879-884

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon2006

    • Author(s)
      T. Shimakami, M. Honda, T. Kusakawa, T. Murata, K. Shimotohno, S. Kaneko, S. Murakami
    • Journal Title

      J Virol. 80

      Pages: 3332-3340

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] High expression of APOBEC3G in patients infected with hepatitis C virus2006

    • Author(s)
      Y. Komohara, H. Yano, S. Shichijo, K. Shimotohno, K. Itoh, A. Yamada
    • Journal Title

      J Mol Histol 37(8-9)

      Pages: 327-332

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Diverse effects of cyclosporine on hepatitis C virus strain replication2006

    • Author(s)
      N. Ishii, K. Watashi, T. Hishiki, K. Goto, D. Inoue, M. Hijikata, T. Wakita, N. Kato, K. Shimotohno
    • Journal Title

      J Virol. 80

      Pages: 4510-4520

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Epigenetic silencing of interferon-inducible genes is implicated in interferon resistance of hepatitis C virus replicon-harboring cells2006

    • Author(s)
      K. Naka, K. Abe, K. Takemoto, H. Dansako, M. Ikeda, K. Shimotohno, N. Kato
    • Journal Title

      J Hepatol 44

      Pages: 869-878

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons2006

    • Author(s)
      H. Hamazaki, S. Ujino, N. Miyano-Kurosaki, K. Shimotohno, H. Takaku
    • Journal Title

      Biochem Biophys Res Commun. 343

      Pages: 988-994

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Diverse effects of cyclosporine on hepatitis C virus strain replication.2006

    • Author(s)
      N.Ishii, K.Shimotohno et al.(total 9, last)
    • Journal Title

      J Virol. 80(9)

      Pages: 4510-4520

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] RNAi expression mediated inhibition of HCV replication2006

    • Author(s)
      H. Hamazaki, S. Ujino, E. Abe, N. Miyano-Kurosaki, K. Shimotohno, H. Takaku
    • Journal Title

      Nucleic Acids Symp Ser (Oxf) 48

      Pages: 307-308

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons2006

    • Author(s)
      H. Hamazaki, S. Ujino, N. Miyano-Kurosaki, K. Shimotohno, H. Takaku
    • Journal Title

      Biochem Biophys Res Commun. 343(3)

      Pages: 988-994

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E2006

    • Author(s)
      T. Murata, K. Shimotohno
    • Journal Title

      J Biol Chem. 281(30)

      Pages: 20788-20800

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Inhibition of HCV replication in HCV replicon by shRNAs2006

    • Author(s)
      H. Hamazaki, H. Takahashi, K. Shimotohno, N. Miyano-Kurosaki, H. Takaku
    • Journal Title

      Nucleosides Nucleotides Nucleic Acids 25(7)

      Pages: 801-805

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] High-throughput screening of low molecular weight NS3-NS4A protease inhibitors using a fluorescence resonance energy transfer substrate2005

    • Author(s)
      K. Sudo, K. Yamaji, K. Kawamura, T. Nishijima, N. Kojima, Aibe K, K. Shimotohno, Y. Shimizu
    • Journal Title

      Antivir Chem Chemother. 16

      Pages: 385-392

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Exploiting cis-Acting Replication Elements To Direct Hepatitis C Virus-Dependent Transgene Expression2005

    • Author(s)
      J. Zhang, O. Yamada, T. Sakamoto, H. Yoshida, H. Araki, K. Shimotohno
    • Journal Title

      J Virol. 79

      Pages: 5923-5932

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Interferon resistance of hepatitis C virus replicon-harbouring cells is caused by functional disruption of type I interferon receptors2005

    • Author(s)
      K. Naka, K. Takemoto, K. Abe, H. Dansako, M. Ikeda, K. Shimotohno, *N. Kato
    • Journal Title

      J Gen Virol. 86

      Pages: 2787-2792

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Role of cyclophilin B in activation of interferon regulatory factor-32005

    • Author(s)
      Y. Obata, K. Yamamoto, M. Miyazaki, K. Shimotohno, S. Kohno, T. Matsuyama
    • Journal Title

      J Biol Chem. 280

      Pages: 18355-18360

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues2005

    • Author(s)
      Y. Murakami, T. Yasuda, K. Saigo, T. Urashima, H. Toyoda, T. Okanoue, K. Shimotohno
    • Journal Title

      Oncogene 25

      Pages: 2537-2545

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Enhancement of internal ribosome entry site-mediated translation and replication of hepatitis C virus by PD980592005

    • Author(s)
      T. Murata, M. Hijikata, K. Shimotohno
    • Journal Title

      Virology 340

      Pages: 105-115

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Genetic variation and dynamics of hepatitis C virus replicons in long-term cell culture2005

    • Author(s)
      N. Kato, T. Nakamura, H. Dansako, K. Namba, K. Abe, A. Nozaki, K. Naka, M. Ikeda, K. Shimotohno
    • Journal Title

      J Gen Virol. 86

      Pages: 645-656

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Suppression of hepatitis C virus replicon by TGF-beta2005

    • Author(s)
      T. Murata, T. Ohshima, M. Yamaji, M. Hosaka, Y. Miyanari, M. Hijikata, K. Shimotohno
    • Journal Title

      Virology 331

      Pages: 407-417

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase2005

    • Author(s)
      K. watashi, N. Ishii, M. Hijikata, D. Inoue, T. Murata, Y. Miyanari, K. Shimotohno
    • Journal Title

      Mol. Cell 19

      Pages: 111-122

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase2005

    • Author(s)
      K. Watashi, N. Ishii, M. Hijikata, D. Inoue, T. Murata, Y. Miyanari, K. Shimotohno
    • Journal Title

      Mol Cell. 19

      Pages: 111-122

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.2005

    • Author(s)
      K.Watashi, K.Shimotohno et al.(total 7, last)
    • Journal Title

      Mol.Cell 19(1)

      Pages: 111-122

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Inhibition of hepatitis C virus replication by pol III-directed overexpression of RNA decoys corresponding to stem-loop structures in the NS5B coding region2005

    • Author(s)
      J. Zhang, O. Yamada, T. Sakamoto, H. Yoshida, H. Araki, T. Murata, K. Shimotohno
    • Journal Title

      Virology 342

      Pages: 276-285

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] Analysis of the 5' end structure of HCV subgenomic RNA replicated in a Huh7 cell line2005

    • Author(s)
      H. Takahashi, M. Yamaji, M. Hosaka, H. Kishine, M. Hijikata, K. Shimotohno
    • Journal Title

      Intervirology 48

      Pages: 104-111

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Journal Article] The role of notch signaling in the development of intrahepatic bile ducts.2004

    • Author(s)
      K.Shimotohno(他4名)
    • Journal Title

      Gastroenterology 127(6)

      Pages: 1775-1786

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner.2004

    • Author(s)
      K.Shimotohno.(他7名)
    • Journal Title

      Oncogene 23(45)

      Pages: 7593-7600

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Establishment of a hepatitis C virus subgenomic replicon derived from human hepatocytes infected in vitro.2003

    • Author(s)
      Kato N, Sugiyama K, Namba K, Dansako H, Nakamura T, Takami M, Naka K, Nozaki A, Shimotohno K.
    • Journal Title

      Biochem Biophys Res Commun. 306

      Pages: 756-766

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12212001
  • [Journal Article] Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus2003

    • Author(s)
      Watashi K, Hijikata M, Tagawa A, Doi T, Marusawa H, Shimotohno K.
    • Journal Title

      Mol Cell Biol. 23

      Pages: 7498-7509

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12212001
  • [Journal Article] Hepatitis virus Non-structural proteins in the probable membranous compartment function in viral RNA replication2003

    • Author(s)
      Miyanari Y, Hijikata M, Yamaji M, Hosaka M, Takahashi H, Shimotohno K.
    • Journal Title

      J Biol Chem. 278

      Pages: 50301-50308

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12212001
  • [Journal Article] Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes2003

    • Author(s)
      Watashi K, Hijikata M, Hosaka M, Yamaji M, Shimotohno K.
    • Journal Title

      Hepatology. 38

      Pages: 1282-1288

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12212001
  • [Journal Article] Subgenomic replicon derived from a cell line infected with the hepatitis C virus.2002

    • Author(s)
      Kishine H, Sugiyama K, Hijikata M, Kato N, Takahashi H, Noshi T, Nio Y, Hosaka M, Miyanari Y, Shimotohno K.
    • Journal Title

      Biochem Biophys Res Commun. 293

      Pages: 993-999

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12212001
  • [Journal Article] Cytoplasmic localization is important for transcription factor nuclear factor-kappa B activation by hepatitis C virus core protein through its amino terminal region2001

    • Author(s)
      Watashi K, Hijikata M, Marusawa H, Doi T, Shimotohno K.
    • Journal Title

      Virology. 286

      Pages: 391-402

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12212001
  • [Journal Article] Chemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti-hepatitis C virus strategy

    • Author(s)
      K. Watashi, K. Shimotohno
    • Journal Title

      Rev Med Virol. 2007(in press)

    • Data Source
      KAKENHI-PROJECT-17013045
  • [Patent] 抗HCV 薬2012

    • Inventor(s)
      田中晴雄、下遠野邦忠, ほか
    • Industrial Property Rights Holder
      学校法人明星学苑
    • Industrial Property Number
      2012-268884
    • Filing Date
      2012-12-08
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Patent] サイクロフィリンを用いた抗HCV剤のアッセイ方法2005

    • Inventor(s)
      下遠野 邦忠他
    • Industrial Property Rights Holder
      京都大学, 塩野義製薬(株)
    • Filing Date
      2005-09-22
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Presentation] Augmented productions of inflammatory cytokines by novel mechanisms in HCV-infected liver2013

    • Author(s)
      Shimizu Y, Nishitsuji H, Shimotohno K, et al.,
    • Organizer
      The 3rd international symposium on carcinogenic spiral and international symposium on tumor biology
    • Place of Presentation
      Kanazawa
    • Year and Date
      2013-01-24
    • Data Source
      KAKENHI-PLANNED-22114004
  • [Presentation] HCV感染培養肝細胞は肝星状細胞と共培養する事によりMIP-1 beta産生を誘導する2013

    • Author(s)
      西辻 裕紀、清水 裕子、宇治野 真之、舟見 健児、川上 志保、瀬谷 司、下遠野 邦忠
    • Organizer
      平成24年度 文部科学省新学術領域研究がん研究分野の特性等を踏まえた支援活動公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-01-30
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Presentation] Augmented productions of inflammatory cytokines by novel mechanisms in HCV-infected liver2013

    • Author(s)
      Yuko Shimizu, Hironori Nishitsuji, Hiroyuki Murasawa, Kenji Funami, Tsukasa Seya, Saneyuki Ujino, Ritsuko Shina, Hiromi Yamamoto, Atsuko Tsukimoto, Kunitada Shimotohno
    • Organizer
      The 3rd international symposium on carcinogenic spiral and international symposium on tumor biology
    • Place of Presentation
      金沢
    • Year and Date
      2013-01-24
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Presentation] Hepatitis C virus sustains the level of AP0BEC1 19th international symposium on hepatitis C virus and related virus2012

    • Author(s)
      Shimizu Y, Nishitsuj i H, Shimotohno K, et al.
    • Organizer
      International symposium on hepatitis C virus and related virus
    • Place of Presentation
      Italia
    • Year and Date
      2012-10-08
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Presentation] Hepatitis C virus sustains the level of APOBEC12012

    • Author(s)
      Yuko SHIMIZU, Saneyuki UJINO, Hironori NISHITSUJI, Hiroshi TAKAKU and Kunitada SHIMOTOHNO
    • Organizer
      19th international symposium on hepatitis C virus and related virus
    • Place of Presentation
      ベネチア(イタリア)
    • Year and Date
      2012-10-08
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Presentation] C型肝炎ウイルスによるAPOBEC1 mRNA安定化とIL-8産生2012

    • Author(s)
      清水 裕子、宇治野 真之、 西辻 裕紀、椎名 律子、山本 祐美、高久 洋、下遠野 邦忠
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Presentation] HCV感染肝細胞は肝星状細胞と共培養する事によりMIP-1 beta産生をあげる2012

    • Author(s)
      西辻 裕紀、舟見 健児、清水 裕子、宇治野 真之、山本 祐美、鈴木 律子、川上 志保、瀬谷 司、高久 洋、下遠野 邦忠
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-13
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Presentation] C型肝炎ウイルスによるAPOBEC1 mRNAの安定化2012

    • Author(s)
      清水 裕子、宇治野 真之、 西辻 裕紀、高久 洋、下遠野 邦忠
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-14
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Presentation] Hepatitis C virus hijacks lipid metabolism for its proliferation ; likely underlying mechanisms for the development of hepatocellular carcinoma2011

    • Author(s)
      Shimizu Y, Ujino S, Funami K, Kunitada Shimotohno K
    • Organizer
      International Congress of Virologist
    • Place of Presentation
      Sapporo(北海道)
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-22249012
  • [Presentation] Hepatitis C virus hijacks lipid metabolism for its proliferation ; likely underlying mechanisms for the development of hepatocellular carcinoma2011

    • Author(s)
      Shimizu Y, Ujino S, Funami K, Kunitada Shimotohno K
    • Organizer
      International Congress of Virologist
    • Place of Presentation
      Sapporo(北海道)
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PLANNED-22114004
  • [Presentation] Apolipoprotein E isoform affects infectivity of HCV2010

    • Author(s)
      Shimotohno K (Hishiki T)
    • Organizer
      17^<th> Int.HCV and related viruses meeting
    • Place of Presentation
      Yokohama (Japan)
    • Year and Date
      2010-09-14
    • Data Source
      KAKENHI-PLANNED-22114004
  • [Presentation] Lipoproteins are involved in infectivity of the HCV particles2009

    • Author(s)
      Shimizu Y.Shimotohno K, et al.
    • Organizer
      The 16^<th> Int. Symp. On HCV and related viruses
    • Place of Presentation
      Nice, France
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Presentation] Lipoproteins are involved in infectivity of the HCV particles2009

    • Author(s)
      Shimizu Y. Shimotohno K, et al.
    • Organizer
      The 16th Int. Symp. On HCV and related viruses
    • Place of Presentation
      Nice, France
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Presentation] Apolipoprotein E is essential for infectivity of HCV2009

    • Author(s)
      Hishiki T, Shimotohno K., et al.
    • Organizer
      The 16th Int. Symp. On HCV and related viruses
    • Place of Presentation
      Nice, France
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Presentation] Apolipoprotein E is essential for infectivity of HCV2009

    • Author(s)
      Hishiki T, Shimotohno K., et al.
    • Organizer
      The 16^<th> Int. Symp. On HCV and related viruses
    • Place of Presentation
      Nice, France
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Presentation] Genetic analysis of HCV with defective genome and its infctivity in vitro2009

    • Author(s)
      Sugiyama K., Shimotohno K., et al.
    • Organizer
      The 16^<th> Int. Symp.On HCV and related viruses
    • Place of Presentation
      Nice, France
    • Data Source
      KAKENHI-PROJECT-20390135
  • [Presentation] Genetic analysis of HCV with defective genome and its infctivity in vitro2009

    • Author(s)
      Sugiyama K., Shimotohno K., et al.
    • Organizer
      The 16th Int. Symp. On HCV and related viruses
    • Place of Presentation
      Nice, France
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Presentation] Genetic analysis of HCV with defective genome and its infctivity in vitro.2009

    • Author(s)
      Sugiyama K., Shimotohno K., et. al.
    • Organizer
      The 16th Int. Symp. On HCV and related viruses
    • Place of Presentation
      Nice, France
    • Data Source
      KAKENHI-PROJECT-20390135
  • [Presentation] Aberrant expression of miR-224 has a potential for hepatocarcinogenesis2008

    • Author(s)
      Murakami Y, Okanoue T and Shimotohno K
    • Organizer
      JCA 67^<th> Annual meeting
    • Place of Presentation
      Nagoya
    • Data Source
      KAKENHI-PROJECT-19590760
  • [Presentation] がんウイルスと癌2008

    • Author(s)
      下遠野邦忠
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-23
    • Data Source
      KAKENHI-PROJECT-17013045
  • [Presentation] Novel approach for HCV regulation by using miRNA2007

    • Author(s)
      Murakami Y, Ali HH, Hijikata M, and Shimotohno K
    • Organizer
      JCA 66^<th> Annual meeting
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-19590760
  • [Presentation] A novel hepatitis B virus vector for drug discovery

    • Author(s)
      Kunitada Shimotohno
    • Organizer
      The 11th JSH Single Topic Conference; Hepatitis B- Recent Progress in Basic and Clinical Research
    • Place of Presentation
      ホテルグランヴィア広島
    • Year and Date
      2014-11-20 – 2014-11-21
    • Invited
    • Data Source
      KAKENHI-PLANNED-22114004
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  • 6.  加藤 篤 (40152699)
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