MITSUMORI Kunitoshi 三森国敏

Researcher Number	10239296
Affiliation (based on the past Project Information) *help	2015: 東京農工大学, 農学研究院, 教授 2012: 東京農工大学, (連合)農学研究科(研究院), 教授 2009 – 2012: 東京農工大学, 大学院・農学研究院, 教授 2007: Tokyo University ofAgriculture and Technology, Institute of Symbiotic Science and Technology, Professor 2006: 東京農工大学, 大学院共生科学技術研究院, 教授 1997 – 1999: 国立医薬品食品衛生研究所, 病理部, 室長 1996: 国立衛生試験所, 病理部, 室長
Review Section/Research Field	Principal Investigator Applied veterinary science / Basic veterinary science/Basic zootechnical science Except Principal Investigator Living organism molecular science / Applied veterinary science / Biological Sciences
Keywords	Principal Investigator K-ras遺伝子 / ラット / p53 supressor oncogene / human prototype c-Ha-ras gene / p53 deficient mice / rasH2 mice / transgenic mice / 子宮腫瘍 / 肺腫瘍 / 肝腫瘍 … More / 膀胱腫瘍 / 皮膚腫瘍 / 前胃腫瘍 / p53癌抑制遺伝子 / ヒトプロト型c-Ha-ras遺伝子 / p53ノックアウトマウス / rasH2マウス / p53 癌抑制遺伝子 / ヒトプロト型 c-Ha-ras 遺伝子 / p53 ノックアウトマウス / rasH2 マウス / トランスジェニックマウス / オメプラゾール / 活性酸素 / 肝発がん / N-acetyl-1-cysteine(NAC) / 抗酸化剤 / Indole-3-carbinol(I3C) / CYP1A誘導剤 / 腫瘍プロモーション抑制 / N-acetyl-L-cystein / 酸化ストレス / インドール-3-カルビノール / 肝腫瘍プロモーション / microsatellite instability / heat shock protein / P53癌抑制遺伝子 / 甲状腺増殖性病変 … More Except Principal Investigator がん / 病理形態学 / 遺伝子改変マウス / がん分子標的薬剤 / ATL発症リスク / ATL発がん機序 / がん化学予防 / 分子疫学コーホート研究 / ATL発症予防 / 国際交流 / 個別化がん予防 / ゲノム・エピゲノム解析支援 / アカデミア創薬 / 次世代分子解析技術 / ゲノムコーホート研究 / 国際研究者交流 / 若手支援 / Plasminogen / Cancer / Angiogenesis / Proteolysis / Pharmacological activity / Bioactive compound / 慢性肝障害 / プラスミノゲン / 血管新生 / プロテオリシス / 薬理活性 / 生理活性物質 / 短期発がんスクリーニング / 発がん性短期予測 / アポトーシス / 細胞周期 / 細胞増殖活性 / 巨大核 / 短期予測 / 発がん性評価 / 病理学 / 遺伝子トラップ / ノックアウト / トランスジェニック / 遺伝子改変マスウ / 組織診断 / データベース / 遺伝学的モニタリング / 微生物学的モニタリング / 凍結保存 / 相同組換え Less

Search for in vivo early prediction markers of carcinogenicity based on the induction mechanism of karyomegaly
- Principal Investigator
  
  SHIBUTANI Makoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Tokyo University of Agriculture and Technology
ＣＹＰ１Ａｉｎｄｕｃｅｒの肝発がん性に関する分子病理学的研究Principal Investigator
- Principal Investigator
  
  三森国敏
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Tokyo University of Agriculture and Technology
Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- Principal Investigator
  
  IMAI Kohzoh, 中村祐輔
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Physiological characterization of the plasminogen modulators
- Principal Investigator
  
  HASUMI Keiji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Tokyo University of Agriculture and Technology
Integrated cancer research using in vivo models
- Principal Investigator
  
  YAMAMURA Kenichi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Studies on the elucidation of the enhanced mechanism of chemical carcinogenesisPrincipal Investigator
- Principal Investigator
  
  MITSUMORI Kunitoshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  National Institute of Health Sciences
ラット甲状腺増殖性病変の組織表現型と癌遺伝子発現との関連性Principal Investigator
- Principal Investigator
  
  三森国敏
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  国立衛生試験所

All 2013 2012 2011

All Journal Article Presentation

[Journal Article] Cellular distribution of cell cycle-related molecules in the renal tubules of rats treated with renal carcinogens for 28 days-Relationship between cell cycle aberration and carcinogenesis2012
- Author(s)
  Taniai E, Hayashi H, Yafune A, Watanabe M, Akane H, Suzuki K, Mitsumori K, Shibutani M
- Journal Title
  
  Archives of Toxicology
  
  Volume: (印刷中) Issue: 9 Pages: 1453-1464
- DOI
  10.1007/s00204-012-0829-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J03954, KAKENHI-PROJECT-22380163
[Journal Article] Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a (p16^Ink4a) in early-stage liver tumor-promotion facilitating iver cell regeneration in rats2012
- Author(s)
  Tsuchiya, T., Wang, L., Yafune, A., Kimura, M., Ohishi, T., Suzuki, K., Mitsumori, K., Shibutani, M
- Journal Title
  
  Toxicology
  
  Volume: 299(2-3) Issue: 2-3 Pages: 146-154
- DOI
  10.1016/j.tox.2012.05.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380163
[Journal Article] Aberrant activation of ubiquitin D at G_2 phase and apoptosis by carcinogens that evoke cell proliferation after 28-day administration in rats2012
- Author(s)
  Taniai, E., Yafune, A., Hayashi, H., Itahashi, M., Hara-Kudo, Y., Suzuki, K., Mitsumori, K., Shibutani, M
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 37(6) Pages: 1093-1111
- NAID
  10031126015
- URL
  http://dx.doi.org/10.2131/jts.37.1093.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380163
[Journal Article] Fluctuations in cell proliferation, apoptosis, and cell cycle regulation at the early stage of tumor promotion in rat two-stage carcinogenesis models2012
- Author(s)
  Taniai, E., Yafune, A., Kimura, M., Morita, R., Nakane, F., Suzuki, K., Mitsumori, K., Shibutani, M
- Journal Title
  
  J. Toxicol. Sci
  
  Volume: 37(6) Pages: 1113-1126
- NAID
  10031126016
- URL
  http://dx.doi.org/10.2131/jts.37.1113.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380163
[Journal Article] Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats2011
- Author(s)
  Keisuke Shimamoto, Hitomi Hayashi, Eriko Taniai, Reiko Morita, Masako Imaoka, Yuji Ishii, Kazuhiko Suzuki, Makoto Shibutani, Kunitoshi Mitsumori
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 36 Issue: 6 Pages: 775-786
- DOI
  10.2131/jts.36.775
- NAID
  10030036910
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580331
[Journal Article] Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine2011
- Author(s)
  Keisuke Shimamoto, Yasuaki Dewa, Yuji Ishii, Sayaka Kemmochi, Eriko Taniai, Hitomi Hayashi, Masako Imaoka, Reiko Morita, Kazunori Kuwata, Kazuhiko Suzuki, Makoto Shibutani, Kunitoshi Mitsumori
- Journal Title
  
  Toxicology
  
  Volume: 283 Issue: 2-3 Pages: 109-117
- DOI
  10.1016/j.tox.2011.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580331
[Journal Article] Indole-3-carbinol enhances oxidative stress responses resulting in the in duction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine2011
- Author(s)
  Keisuke Shimamoto, Yasuaki Dewa, Yuji Ishii, Sayaka Kemmochi, Eriko Taniai, Hitomi Hayashi, Masako Imaoka, Reiko Morita, Kazunori Kuwata, Kazuhiko Suzuki, Makoto Shibutani Kunitoshi Mitsumori
- Journal Title
  
  Toxicology
  
  Volume: 未定
- Data Source
  KAKENHI-PROJECT-22580331
[Journal Article] Relationship between CYP1A induction by indole-3-carbinol or flutamide and liver tumor-promoting potential in rats2011
- Author(s)
  Keisuke Shimamoto, Yasuaki Dewa, Sayaka Kemmochi, Eriko Taniai, Hitomi Hayashi, Masako Imaoka, Makoto Shibutani, Kunitoshi Mitsumori
- Journal Title
  
  Archives of Toxicology
  
  Volume: 85 Issue: 9 Pages: 1159-1166
- DOI
  10.1007/s00204-010-0640-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580331
[Presentation] ラット二段階発がんモデルを用いた発がんプロモーション過程早期における細胞増殖、アポトーシス及び細胞周期関連分子の局在変化2013
- Author(s)
  谷合枝里子、八舟宏典、盛田怜子、板橋恵、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第29回日本毒性病理学会学術集会,第29回日本毒性病理学会学術集会講演要旨集
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] チオアセタミドのラット肝発がん促進時に誘発される細胞周期以上に対する酸化性ストレスの関与2012
- Author(s)
  木村真之、藤井雄太、山本龍一、谷合枝里子、八舟宏典、林新茂、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第39回日本毒性学会学術集会,第39回日本毒性学会学術集会講演要旨集
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 発がん標的性の異なる発がん物質のラットに対する28日間投与時の各標的臓器でのラット腎発がん物質反応指標の変動2012
- Author(s)
  谷合枝里子、八舟宏典、盛田怜子、赤根弘敏、林仁美、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第28回日本毒性病理学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 発がん標的性の異なる発がん物質のラットに対する28日間投与時の各標的臓器でのラット腎発がん物質反応指標の変動2012
- Author(s)
  谷合枝里子、八舟宏典、盛田怜子、赤根弘敏、林仁美、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第28回日本毒性病理学会学術集会,第28回日本毒性病理学会学術集会講演要旨集
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 巨大核出現を伴う腎発がん物質の28日間投与時でのラット腎尿細管における細胞周期関連分子の発現挙動2011
- Author(s)
  谷合枝里子、土屋卓磨、黒岩有一、林仁美、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第27回日本毒性病理学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2011-01-28
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] Search for in vivo rapid screening markers of renal carcinogens based on the analysis ofinduction mechanism of karyomegaly2011
- Author(s)
  Eriko Taniai, Hitomi Hayashi, Atsunori Yafune, Liyun Wang, Kazuhiko Suzuki, Kunitoshi Mitsumori, Makoto Shibutani
- Organizer
  9thEuropean Congress of Toxicologic Pathology of the European Society of Toxicologic Pathology
- Place of Presentation
  Uppsala, Sweden
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] Search for rapid detection markers of renal carcinogens based on the karyomegalv-induction mechanism in rats2011
- Author(s)
  Eriko Taniai, Hitomi Hayashi, Atsunori Yafune, Kazuhiko Suzuki, Kunitoshi Mitsumori, Makoto Shibutani
- Organizer
  70th Annual Meeting of the Japanese Cancer Association. Proceedings
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] Search for rapid detection markers of renal carcinogens based on the karyomegaly-induction mechanism in rats2011
- Author(s)
  Eriko Taniai, Hitomi Hayashi, Atsunori Yafune, Kazuhiko Suzuki, Kunitoshi Mitsumori, Makoto Shibutani
- Organizer
  70^<th> Annual Meeting of the Japanese Cancer Association. Proceedings
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 巨大核出現を伴う腎発がん物質の28日間投与時でのラット腎尿細管における細胞周期関連分子の発現挙動2011
- Author(s)
  谷合枝里子、土屋卓磨、黒岩有一、林仁美、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第27回日本毒性病理学会学術集会,第27回日本毒性病理学会学術集会講演要旨集
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] Search for in vivo rapid screening markers of renal carcinogens based on the analysis of induction mechanism of karyomegaly2011
- Author(s)
  Eriko Taniai, Hitomi Hayashi, Atsunori Yafune, Liyun Wang, Kazuhiko Suzuki, Kunitoshi Mitsumori, Makoto Shibutani
- Organizer
  9^<th> European Congress of Toxicologic Pathology of the European Society of Toxicologic Pathology
- Place of Presentation
  Uppsala, Sweden
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 腎発がん物質の28日間短期投与時でのラットの腎尿細管領域の細胞増殖性を考慮した細胞周期関連分子の発現解析2011
- Author(s)
  谷合枝里子、中村憲彦、林仁美、嶋本敬介、WangLiyun、大石巧、剣持明、小西良子、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第38回日本トキシコロジー学会学術集会,第38回日本トキシコロジー学会学術集会講演要旨集
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 腎発がん物質の28日間短期投与時でのラットの腎尿細管領域の細胞増殖性を考慮した細胞周期関連分子の発現解析2011
- Author(s)
  谷合枝里子、中村憲彦、林仁美、嶋本敬介、Wang Liyun、大石巧、剣持明、小西良子、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第38回日本トキシコロジー学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] ラットthioacetamide(TAA)肝発がん促進過程で形成される前がん病変における細胞周期破綻の様式2011
- Author(s)
  土屋卓磨、谷合枝里子、八舟宏典、白木彩子、北条友理、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第152回日本獣医学会学術集会,第152回日本獣医学会学術集会講演要旨集
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 巨大核出現を伴う腎発がん物質の28日間投与ラットの腎尿細管における細胞周期関連分子の発現変化、文部科学省科学研究費補助金がん研究分野の特性等を踏まえた支援活動2011
- Author(s)
  谷合枝里子、土屋卓磨、黒岩有一、林仁美、鈴木和彦、三森国敏、渋谷淳
- Organizer
  個体レベルでのがん研究支援活動
- Place of Presentation
  大津
- Data Source
  KAKENHI-PROJECT-22380163

1. ONODERA Hiroshi (60177285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. YAMAMURA Kenichi (90115197)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. ARAKI Kimi (90211705)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KATOH Hideki (30142053)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKAGATA Naomi (30159058)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. WANIBUCHI Hideki (90220970)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OGAWA Katsuhiro (50045514)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SHIBUTANI Makoto (20311392)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
9. YAMADA Gen (80174712)

# of Collaborated Projects: 1 results

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10. ITOH Toshio (20106644)

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11. NAKO Kazuki (20217657)

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12. OBATA Yuichi (30177290)

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13. YAMAZAKI Yukiko (00239956)

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14. MATSUI Yasuhisa (40241575)

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15. FUKAMACHI Hiroshi (70134450)

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16. USHIJIMA Toshikazu (90232818)

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17. TATEMATSU Masae (70117836)

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18. YASUHARA Kazuo (80174522)

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19. HASUMI Keiji (20208474)

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20. YAGASAKI Kazumi (20166474)

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21. IMAI Kohzoh (60117603)

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22. INOUE Junichiro (70176428)

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23. NAKAMURA Takuro (00180373)

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24. ISHIKAWA Fuyuki (30184493)

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25. YAO Ryouji (80291095)

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26. TAKANO Hiroshi (00241555)

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27. TAKAKURA Akira (60167484)

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28. TOYOKUNI Shinya (90252460)

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29. YAMADA Yasuhiro (70313872)

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30. IMAIDA Katsumi (90160043)

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31. FUTAKUCHI Mitsuru (60275120)

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32. KANDA Hiroaki (90260067)

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33. TANAKA Hideo (60470168)

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34. WAKAI Kenji (50270989)

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35. MIKAMI Haruo (10332355)

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36. SUZUKI Sadao (20226509)

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37. MIURA Katsuyuki (90257452)

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38. WATANABE Yoshiyuki (00191809)

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39. ARISAWA Kokichi (30203384)

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40. TANAKA Keitaro (50217022)

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41. TAKEZAKI Toshiro (50227013)

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42. FURUSHO Norihiro (10346786)

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43. NAITO Mariko (10378010)

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44. OHNAKA Keizo (30325518)

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45. KITA Yoshikuni (30147524)

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46. KURIKI Kiyonori (20543705)

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47. TAMAKAOSHI Akiko (90236737)

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48. EGUCHI Hidetaka (00260232)

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49. KUBO Michiaki (30442958)

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50. HAMAJIMA Nobuyuki (30172969)

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51. NAGATA Chisato (30283295)

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52. HINO Okio (90127910)

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53. TAHARA Hidetoshi (00271065)

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MITSUMORI Kunitoshi 三森 国敏

Research Projects

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Search for in vivo early prediction markers of carcinogenicity based on the induction mechanism of karyomegaly

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ＣＹＰ１Ａｉｎｄｕｃｅｒの肝発がん性に関する分子病理学的研究Principal Investigator

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Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

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Physiological characterization of the plasminogen modulators

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Integrated cancer research using in vivo models

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Studies on the elucidation of the enhanced mechanism of chemical carcinogenesisPrincipal Investigator

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ラット甲状腺増殖性病変の組織表現型と癌遺伝子発現との関連性Principal Investigator

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[Journal Article] Cellular distribution of cell cycle-related molecules in the renal tubules of rats treated with renal carcinogens for 28 days-Relationship between cell cycle aberration and carcinogenesis2012

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[Journal Article] Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a (p16^Ink4a) in early-stage liver tumor-promotion facilitating iver cell regeneration in rats2012

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[Journal Article] Aberrant activation of ubiquitin D at G_2 phase and apoptosis by carcinogens that evoke cell proliferation after 28-day administration in rats2012

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[Journal Article] Fluctuations in cell proliferation, apoptosis, and cell cycle regulation at the early stage of tumor promotion in rat two-stage carcinogenesis models2012

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[Journal Article] Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats2011

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[Journal Article] Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine2011

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MITSUMORI Kunitoshi 三森国敏