Mashima Tetsuo 馬島哲夫

… Alternative Names

MASHIMA Tetsuo 馬島哲夫

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Researcher Number	30311228
Other IDs
Affiliation (Current)	2025: 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 主任研究員
Affiliation (based on the past Project Information) *help	2016 – 2024: 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 主任研究員 2015: 公益財団法人がん研究会, がん化学療法センター・分子生物治療研究部, 主任研究員 2015: 公益財団法人がん研究会, その他部局等, 主任研究員 2015: 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 主任研究員 2014: 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 主任研究員 … More 2013: 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 研究員 2011 – 2012: 公益財団法人がん研究会, がん化学療法センター・分子生物治療研究部, 研究員 2011 – 2012: 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 研究員 2011: がん研究会, がん化学療法センター分子生物治療研究部, 研究員 2009: 財団法人癌研究会, 癌化学療法センター分子生物治療研究部, 研究員 2008: 癌化学療法センター, 分子生物治療研究部, 研究員 2007: Japanese Foundation For Cancer Research, 癌化学療法センター・分子生物治療研究部, 研究員 2006: (財)癌研究会, 癌化学療法センター分子生物治療研究部, 研究員 2005: (財)癌研究会, 癌化学療法センター基礎研究部, 研究員 2001 – 2004: 財団法人癌研究会, 癌化学療法センター・基礎研究部, 研究員 2002: 財団法人癌研究会, 癌研究所・癌化学療法センター・基礎研究部, 研究員 1999 – 2001: 財団法人癌研究会, 癌化学療法センター・基礎研究部, 研究員 1998: 医薬品副作用被害救済, 研究振興調査機構, 派遣研究員 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Clinical oncology / Medical pharmacy / Biological pharmacy / Biological pharmacy Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 55020:Digestive surgery-related / Digestive surgery / Tumor diagnostics / Tumor biology / Biological Sciences
Keywords	Principal Investigator アポトーシス / 癌 / がん幹細胞 / 分子標的治療 / Apaf-1 / 前立腺がん / 脂質代謝 / アポプトソーム / アシルCoA合成酵素 / アポトソーム … More / 薬剤耐性 / グリオキサラーゼ / 抗癌剤 / BETタンパク質 / Persister細胞 / BET阻害剤 / 胃がん / ALDH / CD44 / タンキラーゼ / c-KIT / 大腸がん / 可塑性 / 小胞体ストレス / 癌遺伝子 / がん分子標的治療 / RNAiスクリーニング / Apaf-1様分子 / GLO1 / IAP / Hsp27 / p53 / 耐性克服 / 白血病 / 癌治療 / 耐性 / カスペース / ATF3 / トポイソメラーゼ阻害剤 / 化学療法 … More Except Principal Investigator 胃癌 / 効果予測マーカー / バイオマーカー / がん / 分子探索・プロファイリング / 分子プロファイリング / 生理機能解析 / 病理形態解析 / ゲノム編集 / モデル動物作製 / トランスレーショナルリサーチ / abscopal effect / 免疫チェックポイント阻害薬 / 放射線療法 / 幹細胞 / 胃がん / 免疫 / がん幹細胞 / 放射線 / 癌幹細胞 / Gastric Cancer / Heterogeneity / 治療効果予測因子 / トラスツズマブ / HER2 heterigeneity / Biomarker / Trastuzumab / HER2 heterogeneity / Gastric cancer / HER2 / 細胞死 / 脂質 / 酸化ストレス / 活性酸素 / ATP-クエン酸リアーゼ / メタボローム / 微小環境 / 細胞増殖 / 脂質代謝 / がん分子標的薬剤 / ATL発症リスク / ATL発がん機序 / がん化学予防 / 分子疫学コーホート研究 / ATL発症予防 / 国際交流 / 個別化がん予防 / ゲノム・エピゲノム解析支援 / アカデミア創薬 / 次世代分子解析技術 / ゲノムコーホート研究 / 病理形態学 / 遺伝子改変マウス / 国際研究者交流 / 若手支援 / シゲナル伝達 / 薬学 / 医療・福祉 / ゲノム / シグナル伝達 / 癌 / 癌移転 / 癌転移 / アポトーシス / 耐性克服 / 分子標的 / 耐性遺伝子 / 耐性タンパク / 抗癌剤耐性 / P-糖タンパク Less

先端モデル動物支援プラットフォーム
- Principal Investigator
  
  武川睦寛
- Project Period (FY)
  2022 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)
- Research Institution
  The University of Tokyo
Identification and Analysis of Circulating Biomarkers in Colorectal Cancer Treatment: Insights from Basic Data
- Principal Investigator
  
  Mitsukuni Suenaga
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical and Dental University
Analysis on the mechanisms of plasticity and maintenance of gastric cancer drug-tolerant persister cellsPrincipal Investigator
- Principal Investigator
  
  MASHIMA Tetsuo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Changes in the immunological profile of gastric cancer stem cells due to irradiation
- Principal Investigator
  
  KUMAGAI Koshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Japanese Foundation for Cancer Research
Analysis of the regulation mechanisms of colorectal cancer stem cell maintenance and plasticityPrincipal Investigator
- Principal Investigator
  
  MASHIMA Tetsuo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Identification of biomarkers for novel therapeutic agents in colorectal cancer based on preclinical analysis.
- Principal Investigator
  
  MITSUKUNI SUENAGA
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Japanese Foundation for Cancer Research
Clinical impact of intratumoral HER2 heterogeneity on trastuzumab eficacy
- Principal Investigator
  
  Wakatsuki Takeru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Japanese Foundation for Cancer Research
Analysis of the mechanisms of survival and differentiation inhibition of prostate tumor-propagating cellsPrincipal Investigator
- Principal Investigator
  
  Mashima Tetsuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Japanese Foundation for Cancer Research
Role of oncogenic factors and their cooperations in survival of prostate tumor-propagating cellsPrincipal Investigator
- Principal Investigator
  
  MASHIMA Tetsuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Japanese Foundation for Cancer Research
Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- Principal Investigator
  
  IMAI Kohzoh, 中村祐輔
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Lipid metabolomics to analyze the mechanisms for cellular adaptation to tumor microenvironment
- Principal Investigator
  
  SEIMIYA Hiroyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  公益財団法人がん研究会
   Japanese Foundation For Cancer Research
脂質代謝制御系を標的とした難治がん選択的治療法の開発Principal Investigator
- Principal Investigator
  
  馬島哲夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
アポトソーム選択的活性化化合物を用いた細胞死制御因子同定と癌治療Principal Investigator
- Principal Investigator
  
  馬島哲夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Japanese Foundation For Cancer Research
Molecular therapeutics targeting drug-resistance mechanisms
- Principal Investigator
  
  TOMIDA Akihiro, 鶴尾隆
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
  The University of Tokyo
アポトーシス実行に関わるアポトソーム系制御因子の同定Principal Investigator
- Principal Investigator
  
  馬島哲夫
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Japanese Foundation For Cancer Research
癌細胞の内在性アポトーシス阻害因子とこれを標的とした抗腫瘍薬剤の探索Principal Investigator
- Principal Investigator
  
  馬島哲夫
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
アポトーシス実行に関わるApaf1およびCARD4を制御する新たな蛋白質の同定Principal Investigator
- Principal Investigator
  
  馬島哲夫
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Japanese Foundation For Cancer Research
癌細胞のアポトーシス誘導制御因子を標的とする化合物を用いた新しい癌化学療法の開発Principal Investigator
- Principal Investigator
  
  馬島哲夫
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
抗癌剤による癌細胞のアポトーシスにおける転写誘導遺伝子の同定とその機能の解析Principal Investigator
- Principal Investigator
  
  馬島哲夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Japanese Foundation For Cancer Research
がん細胞の薬剤感受性と抵抗性の分子機構とその制御
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1994 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo

[Book] がん微小環境に１細胞レベルで挑む～技術革新で見えてきた腫瘍内の細胞と免疫応答の多様性、がん悪性化・治療抵抗性の鍵(がん幹細胞を支えるがん微小環境の多様性 3.薬剤耐性胃がん細胞のがん幹細胞性とその生存分子経路)2021
- Author(s)
  馬島哲夫, 清宮啓之
- Total Pages
  220
- Publisher
  羊土社
- ISBN
  9784758103961
- Data Source
  KAKENHI-PROJECT-21K07251
[Book] 別冊医学のあゆみ治療標的としてのがん幹細胞「がん幹細胞と薬剤耐性」2021
- Author(s)
  馬島哲夫、清宮啓之
- Total Pages
  6
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-18K07337
[Book] マウス・ラットモデル作製・解析プロフェッショナル(オミックス解析：表現型・薬物活性とリンクする分子経路の探索)2021
- Author(s)
  室井誠, 馬島哲夫, 牛嶋大, 松浦正明
- Total Pages
  320
- Publisher
  羊土社
- ISBN
  9784758121125
- Data Source
  KAKENHI-PROJECT-21K07251
[Book] ゲノム解析に基づく新しい分子標的治療 : ゲノムワイドな解析および統合的解析による前立腺がん幹細胞の分子標的探索(「がん分子標的治療」)2015
- Author(s)
  馬島哲夫、清宮啓之
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-221S0001
[Book] がん分子標的治療 12巻 4号　ゲノムワイドな解析および統合的解析による前立腺がん幹細胞の分子標的探索2014
- Author(s)
  馬島哲夫, 清宮啓之
- Total Pages
  5
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26430177
[Book] The Lipid 25巻 4号がんと脂質代謝2014
- Author(s)
  馬島哲夫, 右田敏郎, 清宮啓之
- Total Pages
  7
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26430177
[Book] 特集・制がん剤の分子標的スクリーニング成績化学療法基盤支援活動報告-制がん候補物質のスクリーニング成績・第15報2013
- Author(s)
  矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-221S0001
[Book] 特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告‐制がん候補物質のスクリーニング成績・第15報『癌と化学療法オンライン』2013
- Author(s)
  矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘.
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-221S0001
[Book] がんと脂質代謝実験医学 302012
- Author(s)
  右田敏郎、馬島哲夫、清宮啓之
- Data Source
  KAKENHI-PROJECT-23501319
[Book] 癌の分子標的治療-アポトーシス3)p53、アポトソームなど2008
- Author(s)
  馬島哲夫
- Publisher
  南山堂(印刷中)
- Data Source
  KAKENHI-PROJECT-18015048
[Book] 癌の分子標的治療-アポトーシス3)p53、アポトソームなど2008
- Author(s)
  馬島哲夫
- Publisher
  南山堂(印刷中)
- Data Source
  KAKENHI-PROJECT-18790134
[Book] がんにおける脂質代謝、実験医学増刊号「がんと代謝」
- Author(s)
  右田敏郎、馬島哲夫、清宮啓之
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22650230
[Journal Article] BET protein dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer2024
- Author(s)
  Morino Shun、Mashima Tetsuo、Shirai Fumiyuki、Nagayama Satoshi、Katayama Ryohei、Seimiya Hiroyuki
- Journal Title
  
  Cancer Letters
  
  Volume: 584 Pages: 216632-216632
- DOI
  10.1016/j.canlet.2024.216632
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07251, KAKENHI-PROJECT-22K19469, KAKENHI-PROJECT-23K24192
[Journal Article] Pharmacological targeting of histone H3K27 acetylation/BRD4-dependent induction of ALDH1A3 for early-phase drug tolerance of gastric cancer2024
- Author(s)
  Lee Jin、Mashima Tetsuo、Kawata Naomi、Yamamoto Noriko、Morino Shun、Inaba Saori、Nakamura Ayane、Kumagai Koshi、Wakatsuki Takeru、Takeuchi Kengo、Yamaguchi Kensei、Seimiya Hiroyuki
- Journal Title
  
  Cancer Research Communications
  
  Volume: ー Issue: 5 Pages: 1307-1320
- DOI
  10.1158/2767-9764.crc-23-0639
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07251
[Journal Article] <scp>Interleukin‐4 induced 1</scp>‐mediated resistance to an immune checkpoint inhibitor through suppression of <scp>CD8</scp><sup>+</sup> T cell infiltration in melanoma2024
- Author(s)
  Hirose Shiho、Mashima Tetsuo、Yuan Xunmei、Yamashita Makiko、Kitano Shigehisa、Torii Shinichi、Migita Toshiro、Seimiya Hiroyuki
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 3 Pages: 791-803
- DOI
  10.1111/cas.16073
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07265, KAKENHI-PROJECT-21K07251, KAKENHI-PROJECT-22K19469, KAKENHI-PROJECT-23K24192
[Journal Article] Multiple myeloma?associated DIS3 gene is essential for hematopoiesis, but loss of DIS3 is insufficient for myelomagenesis2024
- Author(s)
  Ohguchi Hiroto、Ohguchi Yasuyo、Kubota Sho、Etoh Kan、Hamashima Ai、Usuki Shingo、Yokomizo-Nakano Takako、Bai Jie、Masuda Takeshi、Kawano Yawara、Harada Takeshi、Nakao Mitsuyoshi、Minami Takashi、Hideshima Teru、Araki Kimi、Sashida Goro
- Journal Title
  
  Blood Neoplasia
  
  Volume: 1 Issue: 1 Pages: 100005-100005
- DOI
  10.1016/j.bneo.2024.100005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07862, KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-22H04922
[Journal Article] APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells2023
- Author(s)
  Chen M, Mashima T, Oishi T, Muramatsu Y, Seto Y, Takamatsu M, Kawata N, Morino S, Nakamura A, Inaba S, Yuan X, Maruyama K, Suzuki M, Sato A, Yoshida H, Jang MK, Mizutani A, Takeuchi K, Yamaguchi K, Shirai F, Nagayama S, Katayama R, Seimiya H
- Journal Title
  
  British Journal of Cancer
  
  Volume: 130 Issue: 1 Pages: 151-162
- DOI
  10.1038/s41416-023-02484-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07199, KAKENHI-PROJECT-21K07251, KAKENHI-PROJECT-22K19469, KAKENHI-PROJECT-23K24192
[Journal Article] Potential Molecular Cross Talk Among CCR5 Pathway Predicts Regorafenib Responsiveness in Metastatic Colorectal Cancer Patients2021
- Author(s)
  SUENAGA MITSUKUNI、ZHANG WU、MASHIMA TETSUO、SCHIRRIPA MARTA、CAO SHU、OKAZAKI SATOSHI、BERGER MARTIN D.、MIYAMOTO YUJI、BARZI AFSANEH、YAMAGUCHI TOSHIHARU、LENZ HEINZ-JOSEF
- Journal Title
  
  Cancer Genomics - Proteomics
  
  Volume: 18 Issue: 3 Pages: 317-324
- DOI
  10.21873/cgp.20262
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07235, KAKENHI-PROJECT-21K07251
[Journal Article] Neutralization of the induced VEGF-A potentiates the therapeutic effect of an anti-VEGFR2 antibody on gastric cancer in vivo2021
- Author(s)
  Mashima Tetsuo、Wakatsuki Takeru、Kawata Naomi、Jang Myung-Kyu、Nagamori Akiko、Yoshida Haruka、Nakamura Kenichi、Migita Toshiro、Seimiya Hiroyuki、Yamaguchi Kensei
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 15125-15125
- DOI
  10.1038/s41598-021-94584-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21555, KAKENHI-PUBLICLY-20H04789, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-18K08720, KAKENHI-PROJECT-21K07251, KAKENHI-PROJECT-16H06276
[Journal Article] Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor2021
- Author(s)
  Nishiya Naoyuki、Oku Yusuke、Ishikawa Chie、Fukuda Tsutomu、Dan Shingo、Mashima Tetsuo、Ushijima Masaru、Furukawa Yoko、Sasaki Yuka、Otsu Keishi、Sakyo Tomoko、Abe Masanori、Yonezawa Honami、Ishibashi Fumito、Matsuura Masaaki、Tomida Akihiro、Seimiya Hiroyuki、Yamori Takao、Iwao Masatomo、Uehara Yoshimasa
- Journal Title
  
  Cancer Science
  
  Volume: － Issue: 5 Pages: 1963-1974
- DOI
  10.1111/cas.14839
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05715, KAKENHI-PUBLICLY-20H04789, KAKENHI-PROJECT-18K09526, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K21555, KAKENHI-PROJECT-19H01806, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-19H03526, KAKENHI-PROJECT-21K07251
[Journal Article] Serum IL-8 level as a candidate prognostic marker of response to anti-angiogenic therapy for metastatic colorectal cancer2020
- Author(s)
  Suenaga Mitsukuni、Mashima Tetsuo、Kawata Naomi、Wakatsuki Takeru、Dan Shingo、Seimiya Hiroyuki、Yamaguchi Kensei
- Journal Title
  
  International Journal of Colorectal Disease
  
  Volume: 36 Issue: 1 Pages: 131-139
- DOI
  10.1007/s00384-020-03748-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-18K07280, KAKENHI-PROJECT-18K07337, KAKENHI-PROJECT-21K07251
[Journal Article] ALDH1A3-mTOR axis as a therapeutic target for anticancer drug-tolerant persister cells in gastric cancer.2020
- Author(s)
  Kawakami R, Mashima T, Kawata N, Kumagai K, Migita T, Sano T, Mizunuma N, Yamaguchi K, Seimiya H
- Journal Title
  
  Cancer Sci
  
  Volume: 111 Issue: 3 Pages: 962-973
- DOI
  10.1111/cas.14316
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07337, KAKENHI-PROJECT-19K09136, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-16H06276
[Journal Article] Epidermal growth factor receptor mRNA expression: A potential molecular escape mechanism from regorafenib2020
- Author(s)
  Matsusaka Satoshi、Hanna Diana L.、Ning Yan、Yang Dongyun、Cao Shu、Berger Martin D.、Miyamoto Yuji、Suenaga Mitsukuni、Dan Shingo、Mashima Tetsuo、Seimiya Hiroyuki、Zhang Wu、Lenz Heinz‐Josef
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 2 Pages: 441-450
- DOI
  10.1111/cas.14273
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07280, KAKENHI-PROJECT-18K07337, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523
[Journal Article] c-KIT regulates stability of cancer stemness in CD44-positive colorectal cancer cells2020
- Author(s)
  Tomizawa Fumiya、Jang Myung-Kyu、Mashima Tetsuo、Seimiya Hiroyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 527 Issue: 4 Pages: 1014-1020
- DOI
  10.1016/j.bbrc.2020.05.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-18K07337
[Journal Article] Tankyrase Inhibitors Target Colorectal Cancer Stem Cells via AXIN-Dependent Downregulation of c-KIT Tyrosine Kinase.2020
- Author(s)
  Jang MK, Mashima T, Seimiya H
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 19 Issue: 3 Pages: 765-776
- DOI
  10.1158/1535-7163.mct-19-0668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07337, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-16H06276
[Journal Article] Meeting report of the 14th Japan Korea joint symposium on cancer and aging research: current status of translational research and approaches to precision medicine2019
- Author(s)
  Sueoka Eisaburo、Watanabe Tatsuro、Mashima Tetsuo、Shirakami Yohei、Komori Atsumasa、Matsuo Keitaro、Yoshikawa Hiroshi Y.、Cho Kyung A、Park Tae Jun、Seimiya Hiroyuki、Kim Eung-Gook、Suganuma Masami、Chung Junho
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology
  
  Volume: 印刷中 Issue: 5 Pages: 1263-1271
- DOI
  10.1007/s00432-019-02887-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09850, KAKENHI-PROJECT-18K07337, KAKENHI-PROJECT-18K07968, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523
[Journal Article] In silico chemical screening identifies epidermal growth factor receptor as a therapeutic target of drug-tolerant CD44v9-positive gastric cancer cells.2019
- Author(s)
  Mashima T, Iwasaki R, Kawata N, Kawakami R, Kumagai K, Migita T, Sano T, Yamaguchi K, Seimiya H
- Journal Title
  
  Br J Cancer
  
  Volume: 121 Issue: 10 Pages: 846-856
- DOI
  10.1038/s41416-019-0600-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07337, KAKENHI-PROJECT-19K09136, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-16H06276
[Journal Article] A phase I study to determine the maximum tolerated dose of trifluridine/tipiracil and oxaliplatin in patients with refractory metastatic colorectal cancer: LUPIN study2019
- Author(s)
  Suenaga Mitsukuni、Wakatsuki Takeru、Mashima Tetsuo、Ogura Mariko、Ichimura Takashi、Shinozaki Eiji、Nakayama Izuma、Osumi Hiroki、Ota Yumiko、Takahari Daisuke、Chin Keisho、Seimiya Hiroyuki、Yamaguchi Kensei
- Journal Title
  
  Investigational New Drugs
  
  Volume: 印刷中 Issue: 1 Pages: 2567-2575
- DOI
  10.1007/s10637-019-00749-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07280, KAKENHI-PROJECT-18K07337, KAKENHI-PROJECT-16H04716, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523
[Journal Article] Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand-Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib.2018
- Author(s)
  Suenaga M, Schirripa M, Cao S, Zhang W, Yang D, Ning Y, Cremolini C, Antoniotti C, Borelli B, Mashima T, Okazaki S, Berger MD, Miyamoto Y, Gopez R Jr., Barzi A, Lonardi S, Yamaguchi T, Falcone A, Loupakis F, Lenz HJ
- Journal Title
  
  Clin Colorectal Cancer
  
  Volume: 印刷中 Issue: 2 Pages: e395-e414
- DOI
  10.1016/j.clcc.2018.02.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06860, KAKENHI-PROJECT-18K07280, KAKENHI-PROJECT-18K07337
[Journal Article] Cancer Stem Cells (CSCs) as a Rational Therapeutic Cancer Target, and Screening for CSC-targeting Drugs2017
- Author(s)
  MASHIMA T
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 2 Pages: 129-132
- DOI
  10.1248/yakushi.16-00229-1
- NAID
  130005305863
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-02-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430177
[Journal Article] APC mutations as a predictive biomarker for sensitivity to tankyrase inhibitors in colorectal cancer.2017
- Author(s)
  Noritaka Tanaka, Tetsuo Mashima, Anna Mizutani, Ayana Sato, Aki Aoyama, Bo Gong, Haruka Yoshida, Yukiko Muramatsu, Kento Nakata, Masaaki Matsuura, Ryohei Katayama, Satoshi Nagayama, Naoya Fujita, Yoshikazu Sugimoto, Hiroyuki Seimiya
- Journal Title
  
  Mol. Cancer Ther.
  
  Volume: 16 Issue: 4 Pages: 739-751
- DOI
  10.1158/1535-7163.mct-16-0578
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02368, KAKENHI-PROJECT-16H04715, KAKENHI-PROJECT-16H04716, KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-15K14409, KAKENHI-PROJECT-15K14412
[Journal Article] Pharmaceutical Sciences Advancing Molecular Cancer Therapeutics<br/>～To Improve Rationale and Effectiveness of Molecularly Targeted Drugs～2017
- Author(s)
  NOGUCHI K, MASHIMA T
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 2 Pages: 127-128
- DOI
  10.1248/yakushi.16-00229-F
- NAID
  130005305798
- ISSN
  0031-6903, 1347-5231
- Language
  Japanese
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-26460076
[Journal Article] Serum VEGF-A and CCL5 levels as candidate biomarkers for efficacy and toxicity of regorafenib in patients with metastatic colorectal cancer.2016
- Author(s)
  Suenaga M, Mashima T, Kawata N, Wakatsuki T, Horiike Y, Matsusaka S, Dan S, Shinozaki E, Seimiya H, Mizunuma N, Yamaguchi K, Yamaguchi T.
- Journal Title
  
  Oncotarget.
  
  Volume: 7(23) Issue: 23 Pages: 34811-34823
- DOI
  10.18632/oncotarget.9187
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05105, KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-15K06860
[Journal Article] Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation2015
- Author(s)
  Mashima T, Ushijima M, Matsuura M, Tsukahara S, Kunimasa K, Furuno A, Saito S, Kitamura M, Soma-Nagae T, Seimiya H, Dan S, Yamori T, Tomida A
- Journal Title
  
  Cancer Science
  
  Volume: in press Issue: 7 Pages: 909-920
- DOI
  10.1111/cas.12682
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430120, KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-26640109, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25290061
[Journal Article] TRIB1 supports prostate tumorigenesis and tumor-propagating cell survival by regulation of endoplasmic reticulum chaperone expression2014
- Author(s)
  Mashima T, Soma-Nagae T, Migita T, Kinoshita R, Iwamoto A, Yuasa T, Yonese J, Ishikawa Y, Seimiya H
- Journal Title
  
  Cancer Res
  
  Volume: 74 Issue: 17 Pages: 4888-4897
- DOI
  10.1158/0008-5472.can-13-3718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-221S0001
[Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds2013
- Author(s)
  Ushijima M, Mashima T, Tomida A, Dan S, Saito S, Furuno A, Tsukahara S, Seimiya H, Yamori T, Matsuura M
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Pages: 360-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501319
[Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds.2013
- Author(s)
  Ushijima M, Mashima T, Tomida A, Dan S, Saito S, Furuno A, Tsukahara S, Seimiya H, Yamori T, Matsuura M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104(3) Issue: 3 Pages: 360-368
- DOI
  10.1111/cas.12071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240092, KAKENHI-PROJECT-22300341, KAKENHI-PROJECT-23501319, KAKENHI-PROJECT-23701067, KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-24650626, KAKENHI-PROJECT-24650639, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25290061, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-23117527
[Journal Article] Role of acyl-CoA synthetases in glioma cell survival and its therapeutic implication2011
- Author(s)
  Mashima T, Seimiya H
- Journal Title
  
  Tumors of the Central Nervous System
  
  Volume: 1 Pages: 337-340
- Data Source
  KAKENHI-PROJECT-23501319
[Journal Article] Role of acyl-CoA synthetases in glioma cell survival and its therapeutic implication2011
- Author(s)
  Mashima, T., Seimiya, H.
- Journal Title
  
  Tumors of the Central Nervous System
  
  Volume: 1 Pages: 337-340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650230
[Journal Article] Molecular pharmacological approach reveals potential new strategies to suppress androgen receptor signaling in prostate cancer2011
- Author(s)
  Mashima, T., Okabe, S., Seimiya, H.
- Journal Title
  
  Mol Cell Pharmacol
  
  Volume: 3 Pages: 7-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650230
[Journal Article] Molecular pharmacological approach reveals potential new strategies to suppress androgen receptor signaling in prostate cancer2011
- Author(s)
  Mashima T, Okabe S, Seimiya H
- Journal Title
  
  Mol Cell Pharmacol
  
  Volume: 3 Pages: 7-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501319
[Journal Article] Molecular pharmacological approach reveals potential new strategies to suppress androgen receptor signaling in prostate cancer2011
- Author(s)
  Mashima T, et al
- Journal Title
  
  Mol Cell Pharmacol
  
  Volume: 3 Pages: 7-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Molecular pharmacological approach reveals potential new strategies to suppress androgen receptor signaling in prostate cancer.2011
- Author(s)
  Mashima T
- Journal Title
  
  Mol Cell Pharmacol
  
  Volume: 3 Pages: 7-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501319
[Journal Article] Role of acyl-CoA synthetases in glioma cell survival and its therapeutic implication.2011
- Author(s)
  Mashima T
- Journal Title
  
  Tumors of the Central Nervous System
  
  Volume: 1 Pages: 337-340
- Data Source
  KAKENHI-PROJECT-23501319
[Journal Article] Pharmacological targeting of constitutively active truncated androgen receptor by nigericin and suppression of hormone-refractory prostate cancer cell growth2010
- Author(s)
  Mashima, T., Okabe, S., Seimiya, H.
- Journal Title
  
  Mol Pharmacol
  
  Volume: 78 Pages: 846-854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650230
[Journal Article] De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy.2009
- Author(s)
  Mashima T
- Journal Title
  
  Br J Cancer (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide2009
- Author(s)
  Mashima T, Sato S, Okabe S, Miyata S, Matsuura M, Sugimoto Y, Tsuruo T, Seimiya H.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 1556-62
- NAID
  10027193846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions2009
- Author(s)
  Mashima T, Sato S, Sugimoto Y, Tsuruo T, Seimiya H.
- Journal Title
  
  Oncogene 28
  
  Pages: 9-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy2009
- Author(s)
  Mashima T, Seimiya H, Tsuruo T.
- Journal Title
  
  Br J Cancer. 100
  
  Pages: 1369-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] Acyl-CoA synthetase as a cancer survival factor: its inhiibition enhances the efficacy of etoposide.2009
- Author(s)
  Mashima T
- Journal Title
  
  Cancer Sci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.2009
- Author(s)
  Mashima T
- Journal Title
  
  Oncogene 8
  
  Pages: 9-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] p-53-defective tumors with a functional apoptosome-mediated pathway : a new therapeutic target.2005
- Author(s)
  Mashima, T., et al.
- Journal Title
  
  J.Nat'l Cancer Inst. 97
  
  Pages: 765-777
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target2005
- Author(s)
  Mashima T, Oh-hara T, Sato S, Mochizuki M, Sugimoto Y, Yamazaki K, Hamada J, Tada M, Moriuchi T, Ishikawa Y, Kato Y, Tomoda H, Yamori T, Tsuruo T.
- Journal Title
  
  J Natl Cancer Inst. 97
  
  Pages: 765-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] Defects of the apoptotic pathway as therapeutic target against cancer2005
- Author(s)
  Mashima T, Tsuruo T.
- Journal Title
  
  Drug Resist Updat. 8
  
  Pages: 339-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] Defects of the apoptotic pathway as therapeutic target against cancer.2005
- Author(s)
  Tetsuo Mashima
- Journal Title
  
  Drug Resist.Updat. 8
  
  Pages: 339-343
- Data Source
  KAKENHI-PROJECT-15790057
[Journal Article] p53-defective tumors with a functional apoptosome-mediated pathway : a new therapeutic target.2005
- Author(s)
  Tetsuo Mashima
- Journal Title
  
  J.Natl.Cancer Inst. 97
  
  Pages: 765-777
- Data Source
  KAKENHI-PROJECT-15790057
[Patent] マルチキナーゼ阻害剤の有効性と安全性を予測する検査方法、検査キット、及びバイオマーカー2015
- Inventor(s)
  末永光邦、水沼信之、馬島哲夫、清宮啓之
- Industrial Property Rights Holder
  公益財団法人がん研究会
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-251386
- Filing Date
  2015-12-24
- Data Source
  KAKENHI-PROJECT-221S0001
[Patent] マルチキナーゼ阻害剤の有効性と安全性を予測する検査方法、検査キット、及びバイオマーカー2015
- Inventor(s)
  末永光邦、水沼信之、馬島哲夫、清宮啓之
- Industrial Property Rights Holder
  末永光邦、水沼信之、馬島哲夫、清宮啓之
- Industrial Property Rights Type
  特許
- Filing Date
  2015-12-24
- Data Source
  KAKENHI-PROJECT-15K06860
[Patent] 癌の予防、治療剤2007
- Inventor(s)
  馬島哲夫, 他
- Industrial Property Rights Holder
  癌研究会, 他
- Filing Date
  2007-10-18
- Overseas
- Data Source
  KAKENHI-PROJECT-18790134
[Patent] 癌の予防、治療剤2007
- Inventor(s)
  馬島哲夫他
- Industrial Property Rights Holder
  癌研究会他
- Acquisition Date
  2007-10-18
- Overseas
- Data Source
  KAKENHI-PROJECT-18015048
[Presentation] 胃がんにおける初期薬剤耐性drug-tolerant persister細胞の生成・維持過程における二層性の遺伝子発現応答2024
- Author(s)
  中村彩音、馬島哲夫、李珍、川田直美、熊谷厚志、山口研成、清宮啓之
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] Preclinical analysis and clinical validation to identify biomarkers of regorafenib efficacy in patients with metastatic colorectal cancer.2024
- Author(s)
  Mitsukuni Suenaga, Tetsuo Mashima, Naomi Kawata, Shingo Dan, Hiroyuki Seimiya, Kensei Yamaguchi.
- Organizer
  2024 ASCO GI Cancers Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07235
[Presentation] BET阻害剤によるALDH1A3陽性drug-tolerant persister胃がん細胞の抑制2023
- Author(s)
  李珍、馬島哲夫、川田直美、熊谷厚志、山口研成、清宮啓之
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] 患者由来大腸がん細胞を用いたタンキラーゼ阻害剤ベル型容量反応性の機序探索2023
- Author(s)
  森野峻、馬島哲夫、片山量平、清宮啓之
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] Late B Cell-specific Dis3-knockout Mice Do Not Develop Plasma Cell Neoplasm2023
- Author(s)
  Hiroto Ohguchi, Yasuyo Ohguchi, Sho Kubota, Ai Hamashima, Takako Yokomizo, Kimi Araki, Goro Sashida
- Organizer
  65th ASH Annual Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04922
[Presentation] BET阻害剤による胃がんALDH1A3陽性drug-tolerant persister細胞の標的化2023
- Author(s)
  李珍、馬島哲夫、清宮啓之
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] タンキラーゼ阻害剤に耐性化した患者由来大腸がん細胞のベル型用量反応性機構2023
- Author(s)
  森野峻、馬島哲夫、長山聡、白井文幸、片山量平、清宮啓之
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] アルデヒド脱水素酵素ALDH1A3による胃がん細胞のin vivo腫瘍増殖と小分子阻害剤によるターゲティング2023
- Author(s)
  馬島哲夫、李珍、中村彩音、清宮啓之
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] 消化器がん患者腫瘍由来細胞を用いた薬剤感受性規定因子および耐性応答機序の解明2023
- Author(s)
  馬島哲夫
- Organizer
  日本患者由来がんモデル学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] アルデヒド脱水素酵素ALDH1A3の胃がん腫瘍増殖への寄与と小分子阻害剤による制がん剤の効果増強2023
- Author(s)
  馬島哲夫、李珍、中村彩音、川田直美、熊谷厚志、山口研成、清宮啓之
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] Expression of a survival factor, ALDH1A3, is epigenetically regulated in anticancer drug-tolerant gastric cancer cells2022
- Author(s)
  Jin Lee, Tetsuo Mashima, Koshi Kumagai, Kensei Yamaguchi, Hiroyuki Seimiya
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22H04922
[Presentation] 制がん剤処理後の残存胃がん細胞における治療抵抗性因子ALDH1A3発現のエピゲノム制御2022
- Author(s)
  李珍、馬島哲夫、清宮啓之
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22H04922
[Presentation] Identification of THAP12 as a response determinant of colorectal cancer stem cells to DNA topoisomeraseⅠinhibitors2021
- Author(s)
  Shun Morino, Tetsuo Mashima, Minoru Yoshida, Hiroyuki Seimiya
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] Innate drug resistance of ALDH1A3-enriched cancer cell subpopulation and its plasticity in gastric cancer2021
- Author(s)
  Tetsuo Mashima, Ryuhei Kawakami, Koshi Kumagai, Takeshi Sano, Kensei Yamaguchi, Hiroyuki Seimiya
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] Evaluation of predictive biomarkers for tankyrase inhibitor sensitivity using patient-derived colorectal cancer cells2021
- Author(s)
  Mingjue Chen, Tetsuo Mashima, Yukiko Muramatsu, Yuki Shimizu, Satoshi Nagayama, Ryohei Katayama, Hiroyuki Seimiya
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] 胃がん細胞集団に存在するALDH1A3高発現がん細胞の薬剤抵抗性への寄与2021
- Author(s)
  馬島哲夫、清宮啓之
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07251
[Presentation] c-KIT maintains CD44-positive colorectal cancer stem cells.2020
- Author(s)
  Tomizawa F, Jang MK, Mashima T, Seimiya H
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] ALDH1A3は制がん剤処理後の残存胃がん細胞で発現亢進し、増殖と造腫瘍性に寄与する2020
- Author(s)
  馬島哲夫、川上隆兵、清宮啓之
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] shRNAスクリーニングによる大腸がん幹細胞の新規治療標的分子の探索2020
- Author(s)
  森野峻、馬島哲夫、吉田稔、清宮啓之
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] ALDH1A3 as a marker and therapeutic target for residual gastric cancer cells after anticancer drug treatment.2020
- Author(s)
  Tetsuo Mashima, Ryuhei Kawakami, Koshi Kumagai, Toshiro Migita, Takeshi Sano, Kensei Yamaguchi, Hiroyuki Seimiya
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] 受容体型チロシンキナーゼc-KITによる大腸がん幹細胞性の維持2020
- Author(s)
  冨澤文弥、張明キュ、馬島哲夫、清宮啓之
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] Tankyrase Inhibitors target colorectal cancer stem-like cells through an AXIN-dependent mechanisms2019
- Author(s)
  Jang MK, Mashima T, Seimiya H
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] EGFR inhibitors suppress drug-tolerant CD44v+ gastric cancer cell growth and enhance the antitumor effect of irinotecan2019
- Author(s)
  Tetsuo Mashima, Risa Iwasaki, Ryuhei Kawakami, Koshi Kumagai, Toshiro Migita, Takeshi Sano, Kensei Yamaguchi, Hiroyuki Seimiya
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] タンキラーゼ阻害剤による大腸がん幹細胞の増殖抑制とその分子機序2019
- Author(s)
  張明きゅ、馬島哲夫 , 清宮啓之
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] EGFR阻害剤は胃がん薬剤抵抗性に寄与するCD44v発現細胞の増殖を抑制し、イリノテカンの治療効果を増強する2019
- Author(s)
  馬島哲夫 , 岩崎里紗, 川上隆兵, 清宮啓之
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] Targeting colorectal cancer stem cells by tankyrase inhibition2018
- Author(s)
  Tetsuo Mashima, Hiroyuki Seimiya
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] Targeting colorectal cancer stem-like CD44-positive cells by tankyrase inhibitors2018
- Author(s)
  Tetsuo Mashima, Myungkyu Jang, Hiroyuki Seimiya
- Organizer
  14th Japan-Korea Joint Symposium on Cancer and Aging Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] Identification of biomarkers for TAS-102 efficacy in metastatic colorectal cancer patients based on preclinical analysis and clinical validation.2018
- Author(s)
  Suenaga, M., Mashima, T., Kawata, N., Dan, S., Wakatsuki, T., Shinozaki, E., Ichimura, T., Ogura, M., Takahari, D., Osumi, H., Ota, Y., Chin, K., Seimiya, H., Yamaguchi, K., Yamaguchi, T.
- Organizer
  ASCO 2018 Gastrointestinal Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06860
[Presentation] 胃がんの薬剤耐性に寄与するCD44v陽性細胞を標的とする化合物のin silico探索2018
- Author(s)
  馬島哲夫 , 岩崎里紗, 川上隆兵, 清宮啓之他
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] In silico screening for agents targeting drug-tolerant CD44v-positive cells in patient-derived gastric cancer.2018
- Author(s)
  Tetsuo Mashima, Risa Iwasaki, Koshi Kumagai, Ryuhei Kawakami, Takeshi Sano, Kensei Yamaguchi, Hiroyuki Seimiya
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07337
[Presentation] Role of genetic polymorphisms in CCL5/CCR5 axis to predict efficacy of regorafenib in patients with refractory metastatic colorectal cancer.2017
- Author(s)
  Suenaga, M., Schirripa, M., Cao, S., Zhang, W., Yang, D., Marmorino, F., Bergamo, F., Antoniotti, C., Rossini, D., Ning, Y., Okazaki, S., Berger , M., Miyamoto, Y., Gopez, R., Hanna, D., Barzi, A., Mashima, T., Yamaguchi, T., Loupakis, F., Lenz , H.
- Organizer
  ASCO 2017 Gastrointestinal Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06860
[Presentation] がん治療標的としてのがん幹細胞と標的薬剤の探索2016
- Author(s)
  馬島哲夫
- Organizer
  第136回日本薬学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-26430177
[Presentation] 大腸がん幹細胞様CD44陽性細胞に対するタンキラーゼ阻害剤の増殖抑制作用2016
- Author(s)
  馬島哲夫、張明奎、村松由起子、清宮啓之
- Organizer
  第２０回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-26430177
[Presentation] 大腸がん幹細胞様CD44陽性細胞に対するタンキラーゼ阻害剤の増殖抑制効果2016
- Author(s)
  馬島哲夫、村松由起子、清宮啓之
- Organizer
  第７５回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26430177
[Presentation] Gene signature-based approach identifies mTOR as a downstream factor of TRIB1-dependent survival pathways in prostate cancer2016
- Author(s)
  Tetsuo Mashima, Ryoko Kinoshita, Sachiko Okabe, Hiroyuki Seimiya
- Organizer
  Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
- Place of Presentation
  Hyatt Regency Maui Resort and Spa
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430177
[Presentation] 再燃性前立腺がんにおける短鎖型アンドロゲン受容体の役割とその制御物質2014
- Author(s)
  岡部幸子、馬島哲夫、清宮啓之
- Organizer
  文科省新学術領域研究・がん支援「化学療法基盤支援活動」第三回シンポジウムアカデミアからの抗がん剤創薬に向けて-天然物の有効利用
- Place of Presentation
  万国津梁館(沖縄県・名護市)
- Year and Date
  2014-05-12
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] 遺伝子発現解析とRNAi 探索による前立腺がん腫瘍源細胞生存因子の同定2013
- Author(s)
  馬島哲夫
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] 遺伝子発現解析とRNAi探索による前立腺がん腫瘍源細胞生存因子の同定2013
- Author(s)
  馬島哲夫、清宮啓之
- Organizer
  第７２回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] RNAi スクリーニングおよび遺伝子発現データを用いた統合的解析による前立腺がん幹細胞選択的生存因子の同定2013
- Author(s)
  馬島哲夫
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2013-06-12
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] RNAiスクリーニングおよび遺伝子発現データを用いた統合的解析による前立腺がん幹細胞生存因子の同定2013
- Author(s)
  馬島哲夫、湯浅健、清宮啓之
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] 前立腺がん幹細胞を標的とする薬剤の探索系構築と化合物スクリーニング2012
- Author(s)
  馬島哲夫
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Year and Date
  2012-06-28
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] 前立腺がん幹細胞を標的とする化合物のスクリーニング2012
- Author(s)
  馬島哲夫
- Organizer
  第71回日本癌学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] 前立腺がんのがん化と生存におけるTMPRSS2・ERG融合遺伝子の役割2012
- Author(s)
  馬島哲夫
- Organizer
  第12回関東ホルモンと癌研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] 前立腺がんの癌化および生存におけるTMPRSS2-ERG 融合遺伝子の役割2011
- Author(s)
  馬島哲夫
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] Role of TMPRSS2-ERG fusion protein in transformation and maintenance of prostate cancer2011
- Author(s)
  馬島哲夫
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] 前立腺がんの癌化および生存におけるTMPRSS2-ERG融合遺伝子産物の役割2011
- Author(s)
  馬島哲夫
- Organizer
  第15回日本がん分子標的治療学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] Involvement of constitutively active truncated androgen receptor(tAR) in hormone-refractory prostate cancer growth and the tAR inhibition by nigericin2011
- Author(s)
  Mashima T., Okabe S., Seimiya H.
- Organizer
  第10回日韓がん老化合同シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22650230
[Presentation] ナイジェリシンによる恒常活性化型アンドロゲン受容体の抑制はホルモン再燃性前立腺がん細胞増殖を阻害する2011
- Author(s)
  馬島哲夫、岡部幸子、清宮啓之
- Organizer
  第11回関東ホルモンと癌研究会
- Place of Presentation
  東京
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-22650230
[Presentation] 前立腺がんの癌化および生存におけるTMPRSS2-ERG 融合遺伝子産物の役割2011
- Author(s)
  馬島哲夫
- Organizer
  第15回日本がん分子標的治療学会
- Place of Presentation
  東京
- Year and Date
  2011-06-22
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] がん細胞の増殖・生存における脂質代謝酵素の役割2010
- Author(s)
  岡部幸子、右田敏郎、馬島哲夫、清宮啓之
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22650230
[Presentation] 内分泌療法抵抗性前立腺がんにおけるアンドロゲン受容体シグナル評価系の構築2008
- Author(s)
  馬島哲夫
- Organizer
  第8回関東ホルモンと癌研究会
- Place of Presentation
  東京
- Year and Date
  2008-01-19
- Data Source
  KAKENHI-PROJECT-18790134
[Presentation] 内分泌療法抵抗性前立腺がんにおけるアンドロゲン受容体シグナル評価系の構築2008
- Author(s)
  馬島哲夫
- Organizer
  第8回関東ホルモンと癌研究会
- Place of Presentation
  東京
- Year and Date
  2008-01-19
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] 脂肪酸代謝酵素アシルCoAシンターゼ5による脳腫瘍細胞の生存促進と遺伝子発現解析による分子機序の検討2008
- Author(s)
  馬島哲夫
- Organizer
  第12回がん分子標的治療研究会総会
- Place of Presentation
  東京
- Year and Date
  2008-06-26
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] Acyl-CoA synthetase as a survival factor of cancer: itsinhibition enhnces the efficacy of cancer chemotherapy.2008
- Author(s)
  馬島哲夫
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] 内分泌療法抵抗性前立腺がんにおけるアンドロゲン受容体シグナル評価系の構築2008
- Author(s)
  馬島哲夫
- Organizer
  第8回関東ホルモンと癌研究会
- Place of Presentation
  東京
- Year and Date
  2008-01-19
- Data Source
  KAKENHI-PROJECT-18015048
[Presentation] Involvement of Acyl-CoA synthetase 5 in survival of human glioma cells2007
- Author(s)
  馬島哲夫
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18015048
[Presentation] グリオーマ生存における脂肪酸代謝酵素アシルCoAシンターゼの関与とその分子機構2007
- Author(s)
  馬島哲夫
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-18790134
[Presentation] グリオーマ生存における脂肪酸代謝酵素アシルCoAシンターゼの関与とその分子機構2007
- Author(s)
  馬島哲夫
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-18015048
[Presentation] グリオーマ生存における脂肪酸代謝酵素アシルCoAシンターゼの関与とその分子機構2007
- Author(s)
  馬島哲夫
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] Involvement of Acyl-CoA synthetase 5 in survival of human glioma cells2007
- Author(s)
  馬島哲夫
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18790134
[Presentation] Involvement of Acyl-CoA synthetase 5 in survival of human glioma cells2007
- Author(s)
  馬島哲夫
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] TRIB1 supports prostate tumorigenesis and tumor-propagating cell survival via the regulation of endoplasmic reticulum chaperone expression
- Author(s)
  馬島哲夫
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26430177
[Presentation] 前立腺がん幹細胞を標的とする薬剤の探索系構築と化合物スクリーニング
- Author(s)
  馬島哲夫
- Organizer
  第１６回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] Functional genomic approach identified TRIB1 as an oncogenic survival factor in prostate cancer stem-like cells
- Author(s)
  馬島哲夫
- Organizer
  第19回 International Symposium on Cancer Chemotherapy
- Place of Presentation
  科学未来館
- Year and Date
  2014-12-10 – 2014-12-11
- Data Source
  KAKENHI-PROJECT-26430177
[Presentation] 前立腺がん幹細胞を標的とする化合物のスクリーニング
- Author(s)
  馬島哲夫
- Organizer
  第７１回日本癌学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501319
[Presentation] RNAi探索による前立腺がん形成・腫瘍源細胞生存因子TRIB1の同定
- Author(s)
  馬島哲夫
- Organizer
  第6回日本RNAi研究会
- Place of Presentation
  グランドプリンス広島
- Year and Date
  2014-08-28 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-26430177
[Presentation] TRIB1による前立腺がんの腫瘍増殖および腫瘍源細胞の生存維持
- Author(s)
  馬島哲夫
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台市情報産業プラザ
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26430177
[Presentation] An essential factor for prostate tumorigenesis and tumor-propagating cell survival identified by functional genomics and transcriptome analyses
- Author(s)
  馬島哲夫
- Organizer
  第12回日韓がん老化合同シンポジウム
- Place of Presentation
  埼玉県立がんセンター
- Year and Date
  2014-06-19 – 2014-06-21
- Data Source
  KAKENHI-PROJECT-26430177

1. SEIMIYA Hiroyuki (50280623)

# of Collaborated Projects: 5 results

# of Collaborated Products: 23 results
2. TOMIDA Akihiro (40251483)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. DAN Shingo (70332202)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. INOUE Junichiro (70176428)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKAMURA Takuro (00180373)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ARAKI Kimi (90211705)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. YAO Ryouji (80291095)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. TOYOKUNI Shinya (90252460)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. YAMADA Yasuhiro (70313872)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. FUTAKUCHI Mitsuru (60275120)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KANDA Hiroaki (90260067)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. TAHARA Hidetoshi (00271065)

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Mashima Tetsuo 馬島 哲夫

MASHIMA Tetsuo 馬島 哲夫

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Analysis on the mechanisms of plasticity and maintenance of gastric cancer drug-tolerant persister cellsPrincipal Investigator

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Analysis of the regulation mechanisms of colorectal cancer stem cell maintenance and plasticityPrincipal Investigator

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Analysis of the mechanisms of survival and differentiation inhibition of prostate tumor-propagating cellsPrincipal Investigator

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Role of oncogenic factors and their cooperations in survival of prostate tumor-propagating cellsPrincipal Investigator

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脂質代謝制御系を標的とした難治がん選択的治療法の開発Principal Investigator

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アポトソーム選択的活性化化合物を用いた細胞死制御因子同定と癌治療Principal Investigator

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アポトーシス実行に関わるアポトソーム系制御因子の同定Principal Investigator

Mashima Tetsuo 馬島哲夫

MASHIMA Tetsuo 馬島哲夫

[Book] 別冊医学のあゆみ治療標的としてのがん幹細胞「がん幹細胞と薬剤耐性」2021

[Book] がん分子標的治療 12巻 4号　ゲノムワイドな解析および統合的解析による前立腺がん幹細胞の分子標的探索2014

[Book] The Lipid 25巻 4号がんと脂質代謝2014