Ito Akihiro 伊藤昭博

… Alternative Names

ITO Akihiro 伊藤昭博

伊藤昭博イトウアキヒロ

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Researcher Number	40391859
Other IDs
Affiliation (Current)	2025: 東京薬科大学, 生命科学部, 教授 2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 客員主管研究員
Affiliation (based on the past Project Information) *help	2017 – 2024: 東京薬科大学, 生命科学部, 教授 2017 – 2021: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 客員主管研究員 2017: 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 2016 – 2017: 国立研究開発法人理化学研究所, その他, 研究員 2015 – 2016: 国立研究開発法人理化学研究所, 主任研究員研究室等, 専任研究員 … More 2015 – 2016: 国立研究開発法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 2015: 理化学研究所基幹研究所, 吉田化学遺伝学研究室, 専任研究員 2009 – 2015: The Institute of Physical and Chemical Research, 吉田化学遺伝学研究室, 専任研究員 2014: 国立研究開発法人理化学研究所, その他部局等, 研究員 2012: 独立行政法人理化学研究所, 吉田化学遺伝研究室, 専任研究員 2010: 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 專任研究員 2005 – 2006: 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 38030:Applied biochemistry-related / Molecular biology / Biological Sciences / Chemical biology / Applied genomics / Applied biochemistry Except Principal Investigator Animal production science / Broad Section F / Applied animal science / Basic Section 63030:Chemical substance influence on environment-related … More / Basic Section 38060:Applied molecular and cellular biology-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Broad Section K / Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 47040:Pharmacology-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Basic Section 42030:Animal life science-related / General medical chemistry / Pharmacology in pharmacy / Tumor therapeutics Less
Keywords	Principal Investigator アセチル化 / 翻訳後修飾 / Hippo経路 / TEAD / がん / ヒストン / FRET / 蛍光プローブ / リジン脱アセチル化酵素 / アシルCoA … More / 脂質代謝 / アシルCoA合成酵素 / リジン長鎖アシル化 / アシローム / KDAC / YAP / TAZ / リジンアシル化 / 蛋白質 / 癌 / アシル化 / 脂質修飾 / パルミトイル化 / ミリストイル化 / サーチュイン / SIRT2 / 代謝物質 / Sirtuin / ケミカルバイオロジー / SUMOylation / 脱SUMO化酵素 / 抗がん剤 / 阻害剤 / SUMO / ピルビン酸脱水素酵素複合体 / タンパク質アセチル化 / ミトコンドリア / アセチル化酵素 / アグリソーム / 細胞死 / ダイニンモーター / 微小管 / Bim / HDAC6 / p53 / ヒストンH4 / 蛋白質アセチル化 / 蛍光共鳴エネルギー移動 … More Except Principal Investigator インスリン受容体基質 / インスリン / インスリン様成長因子 / 代謝・内分泌制御 / がん / インスリン様活性 / 遺伝子発現 / スプライシング / 糖尿病 / 増殖 / タンパク質付加体 / 代謝フェロモン / 翻訳後修飾 / 化学遺伝学 / 内在性代謝物 / エピジェネティクス / ゼブラフィッシュ / 追いつき成長 / インスリン様シグナル / ニトロシル化 / エピゲノム / 一酸化窒素 / 翻訳 / 細胞内シグナル伝達 / 糖取り込み / インスリン抵抗性 / インスリン様成長因子受容体 / ユビキチンリガーゼ / 細胞内シグナル / 脱ユビキチン化酵素 / 民生品 / カルボン酸 / リジン残基の化学修飾 / 代謝活性化 / エピジェネティクス変化 / 幹細胞 / 神経堤細胞 / 体成長 / 代謝シミュレーション / シミュレーション / 細胞間コミュニケーション / クロマチン / アセチル化 / ヒストン / 生体内運命 / イオウ付加体 / レドックスシグナル / 毒性発現 / レドックスシグナル変動 / アンチポーター / 環境中親電子物 / 活性イオウ分子 / レドックスシグナル系 / エクスポソーム / 複合曝露 / 環境中親電子物質 / 創薬標的分子 / アシル基転移反応 / 脱長鎖アシル化酵素 / 長鎖アシル化酵素 / タンパク質アシル化 / 転写制御 / アシル基転移酵素 / リジンアシル化 / Hippo経路 / TEAD / パーキンソン病 / 神経細胞死 / 阻害薬 / 細胞死 / S-ニトロシル化 / アミノ酸 / ユビキチン化 / インスリン受容体基質（IRS） / 筋分化 / 酸素 / インスリン・インスリン様成長因子シグナル / エネルギーセンサー / サーチュイン / 低酸素 / 代謝調節 / 代謝・内分泌 / インスリン受容体 / ユビキチン / 細胞増殖 / 酸化 / システイン / レドックス / 癌 / 遺伝子変化 / メチル化 / 神経変性疾患 / 薬物スクリーニング / 病態形成 / 炎症反応 / Sーニトロシル化 / 抗がん剤耐性 / 分子標的治療 / アミノ酸栄養 / シグナル伝達 / 生理活性 / mTOR / IGF / 臓器特異的脂肪蓄積 / アミノ酸欠乏食 / 畜産学 / 応用動物 / 栄養学 / 人工知能 / 機械学習 / アミノ酸シグナル / 脂質代謝 / 筋脂肪交雑 / 脂肪肝 / 脂肪合成 / アミノ酸代謝 / ＲＮＡ / リボソーム合成 / RNA / 成長異常 / 2型糖尿病 / 細胞膜移行 / 糖輸送担体（GLUT4) / PIP5K / 高糖尿病薬 / ジアシルグリセロールキナーゼζ / ジアルシグリセロールキナーゼ / 低分子化合物 / ジアシルグリセロールキナーゼ / 糖輸送担体 / アダプタータンパク質 / ユビキチン化酵素 Less

Elucidation of novel regulation of lipid metabolism by lysine lipid modifications and its controlPrincipal Investigator
- Principal Investigator
  
  伊藤昭博
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Understanding the mechanisms of expression and inheritance of epigenetic information by lysine acetylation
- Principal Investigator
  
  梅原崇史
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Uncovering hidden functions of intrinsic metabolites using chemical genetics and informatics
- Principal Investigator
  
  吉田稔
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section F
- Research Institution
  Institute of Physical and Chemical Research
Role of transcription factor Tfcp2l1 in growth spurt phenomena in zebrafish
- Principal Investigator
  
  亀井宏泰
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Kanazawa University
代謝活性化を介した民生品のタンパク質付加体形成によるエピジェネティクス変化
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Kyushu University
Is transcription factor TEAD a missing protein lysine fatty acyltransferase?
- Principal Investigator
  
  YOSHIDA Minoru
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  The University of Tokyo
Innovative chemical genetics on novel function of endogenous metabolites
- Principal Investigator
  
  Yoshida Minoru
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section F
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of cell regulatory mechanism by lysine long-chain fatty modificationsPrincipal Investigator
- Principal Investigator
  
  Ito Akihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Cellular energy-sensing mechanism modulates insulin-like growth factor signaling to facilitate catch-up growth.
- Principal Investigator
  
  Kamei Hiroyasu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Kanazawa University
Regulatory mechanism of ubiquitin modification of insulin receptor substrates and its physiological and pathological significance.
- Principal Investigator
  
  Takahashi Shin-Ichiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  The University of Tokyo
Mechanism of epigenetic regulation by nitric oxide with a novel compound regulating the modification of cysteine residue
- Principal Investigator
  
  Uehara Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Okayama University
Environmental electrophiles exposome and reactive sulfur species as its regulator molecule
- Principal Investigator
  
  Kumagai Yoshito
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section K
- Research Institution
  University of Tsukuba
Identification and functional analyses of lysine long chain fatty acylated proteinsPrincipal Investigator
- Principal Investigator
  
  Ito Akihiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Tokyo University of Pharmacy and Life Science
  Institute of Physical and Chemical Research
Tissue specific lipid accumulation in response to amino acid signal
- Principal Investigator
  
  Hakuno Fumihiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Regulation of epigenetic enzymes via nitrosative stress and development of its specific modulator
- Principal Investigator
  
  Uehara Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Okayama University
Elucidation of molecular mechanisms of alternative splicing of insulin receptor RNA and its physiological significance
- Principal Investigator
  
  Takahashi Shin-Ichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Elucidation of the inhibitory mechanism of a lysine deacetylase Siruin by endogenous metabolitesPrincipal Investigator
- Principal Investigator
  
  Ito Akihiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Institute of Physical and Chemical Research
Roles of Nedd4-IRS complexes in the development of diabetes and cancer
- Principal Investigator
  
  Fukushima Toshiaki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Institute of Technology
  Hiroshima University
Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complex
- Principal Investigator
  
  Takahashi Shin-Ichiro
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
動物の一生において時期・組織特異的にインスリン様活性を制御する新規機構とその意義
- Principal Investigator
  
  高橋伸一郎
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Identification and elucidation of the roles of RNAs associated with insulin receptor substrate
- Principal Investigator
  
  TAKAHASHI Shin-Ichiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Development of drug-resistance-overcoming agents targeting histone demethylase JARID1A
- Principal Investigator
  
  Tamio Mizukami
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Analysis of insulin resistance through DGKz and development of anti-diabetic medicine
- Principal Investigator
  
  Hakuno Fumihiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Study on chemical biology for protein SUMOylationPrincipal Investigator
- Principal Investigator
  
  ITO Akihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  The Institute of Physical and Chemical Research
Novel mechanisms of growth regulation through changes in ubiquitination of insulin receptor substrates
- Principal Investigator
  
  TAKAHASHI Shin-Ichiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
ミトコンドリアに存在する未知のアセチル化酵素の同定Principal Investigator
- Principal Investigator
  
  伊藤昭博
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied genomics
- Research Institution
  The Institute of Physical and Chemical Research
核内のヒストンアセチル化を時空間的に観察可能にする蛍光プローブの開発Principal Investigator
- Principal Investigator
  
  伊藤昭博
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
転写関連因子のアセチル化を可視化するシステムの開発Principal Investigator
- Principal Investigator
  
  伊藤昭博
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
細胞質に局在するヒストン脱アセチル化酵素HDAC6の機能解析Principal Investigator
- Principal Investigator
  
  伊藤昭博
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 「NAD+関連タンパク質」、生体の化学 [増大特集]細胞シグナル操作方法2015
- Author(s)
  伊藤昭博、八代田陽子、吉田稔
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-26650011
[Book] ケミカルエピジェネティクス-化合物によるエピジェネティクス情報の制御2010
- Author(s)
  伊藤環
- Publisher
  羊土社実験医学
- Data Source
  KAKENHI-PROJECT-21651086
[Journal Article] Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy2024
- Author(s)
  Badran Mostafa M.、Abbas Samar H.、Tateishi Hiroshi、Maemoto Yuki、Toma Tsugumasa、Ito Akihiro、Fujita Mikako、Otsuka Masami、Abdel-Aziz Mohamed、Radwan Mohamed O.
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 269 Pages: 116302-116302
- DOI
  10.1016/j.ejmech.2024.116302
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KJ1769, KAKENHI-PROJECT-23H05473
[Journal Article] Extracellularly Secreted Cysteine Derived from Cystine Regulates Oxidative and Electrophilic Stress in HepG2 cells2024
- Author(s)
  Hanako Aoki、Yasuhiro Shinkai Y、Masahiro Akiyama 、Satoshi Yamazaki S、Motohiro Nishida、Yoshito Kumagai
- Journal Title
  
  Free Radical Research
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K28237
[Journal Article] Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP-TEAD interaction and its potential as an anticancer agent2023
- Author(s)
  Saaya Sekine, Shohei Takase, Runa Hayase, Kota Noritsugu, Yuki Maemoto, Yasue Ichikawa, Kenji Ogawa, Yasumitsu Kondoh, Hiroyuki Osada, Minoru Yoshida, Akihiro Ito
- Journal Title
  
  Bioscience, biotechnology, and biochemistry
  
  Volume: 98 Issue: 5 Pages: 501-510
- DOI
  10.1093/bbb/zbad022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05640, KAKENHI-PLANNED-23H04882, KAKENHI-PROJECT-23H05473
[Journal Article] Lysine long-chain fatty acylation regulates the TEAD transcription factor2023
- Author(s)
  K. Noritsugu, T. Suzuki, K. Dodo, K. Ohgane, Y. Ichikawa, K. Koike, S. Morita, T. Umehara, K. Ogawa, M. Sodeoka, N. Dohmae, M. Yoshida, A. Ito
- Journal Title
  
  Cell Rep.
  
  Volume: 42 Issue: 4 Pages: 112388-112388
- DOI
  10.1016/j.celrep.2023.112388
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23H04882, KAKENHI-PROJECT-23H05473
[Journal Article] Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine2023
- Author(s)
  Kohei Matsuo, Yumi Abiko, Shigeru Yamano, Akira Toriba, Kimihiko Matsusue, Yoshito Kumagai
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 2 Pages: 338-342
- DOI
  10.1248/bpb.b22-00543
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15657, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-23K25015, KAKENHI-PROJECT-23K07979, KAKENHI-PROJECT-20K12180
[Journal Article] Annexin <scp>A5</scp> inhibits mast cell activation via Allergin‐1 immunoreceptor2023
- Author(s)
 Almeida Mariana Silva、Tahara‐Hanaoka Satoko、Shibagaki Shohei、Niizuma Kouta、Hitomi Kaori、Shinkai Yasuhiro、Shibayama Shiro、Shibuya Akira
- Journal Title
 
 Allergy
 
 Volume: 78 Issue: 12 Pages: 3258-3260
- DOI
 10.1111/all.15851
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21KK0207, KAKENHI-PUBLICLY-22H04799, KAKENHI-PUBLICLY-22H05555, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-21H02709, KAKENHI-PROJECT-23K28237
[Journal Article] 17β-neriifolin from unripe fruits of Cerbera manghas suppressed cell proliferation via the inhibition of HOXA9-dependent transcription and the induction of apoptosis in the human AML cell line THP-12023
- Author(s)
  Takase S, Yun YS, Moriya F, Sekine S, Yotsumoto S, Miyake K, Yahagi T, Ito A, Inoue H
- Journal Title
  
  J Nat Med
  
  Volume: 77 Issue: 1 Pages: 180-187
- DOI
  10.1007/s11418-022-01659-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06670, KAKENHI-PROJECT-19H05640
[Journal Article] Activation of HSP90/HSF1 Signaling as an Adaptive Response to an Electrophilic Metabolite of Morphine2023
- Author(s)
  Kohei Matsuo, Yumi Abiko, Shigeru Yamano, Kimihiko Matsusue, Yoshito Kumagai
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 2 Pages: 334-337
- DOI
  10.1248/bpb.b22-00531
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15657, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-23K07979, KAKENHI-PROJECT-20K12180
[Journal Article] GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain2023
- Author(s)
  Kikuchi Masaki、Takase Shohei、Konuma Tsuyoshi、Noritsugu Kota、Sekine Saaya、Ikegami Takahisa、Ito Akihiro、Umehara Takashi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 43
- DOI
  10.1073/pnas.2304103120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K05667, KAKENHI-PROJECT-20K06509, KAKENHI-PROJECT-23H05473, KAKENHI-PROJECT-20H03388
[Journal Article] A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression2023
- Author(s)
  Takase S, Hiroyama T, Shirai F, Maemoto Y, Nakata A, Arata M, Matsuoka S, Sonoda T, Niwa H, Sato S, Umehara T, Shirouzu M, Nishigaya Y, Sumiya T, Hashimoto N, Namie R, Usui M, Ohishi T, Ohba SI, Kawada M, Hayashi Y, Harada H, Yamaguchi T, Shinkai Y, Nakamura Y, Yoshida M, Ito A
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 23-23
- DOI
  10.1038/s41467-022-35404-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19462, KAKENHI-PROJECT-22KJ2790, KAKENHI-PLANNED-18H05530, KAKENHI-PROJECT-23K24166, KAKENHI-PROJECT-22K06783, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-19H04355, KAKENHI-PLANNED-23H04882
[Journal Article] Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis2023
- Author(s)
  Nishiyama K, Ariyoshi K, Nishimura A, Kato Y, Mi X, Kurose H, Kim SG, Nishida M.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 4 Pages: 3800-3800
- DOI
  10.3390/ijms24043800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06630, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-22K19395, KAKENHI-PLANNED-21H05269, KAKENHI-PROJECT-23K24035
[Journal Article] Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents2023
- Author(s)
  Yosuke Nishigaya, Shohei Takase, Tatsunobu Sumiya, Ko Kikuzato, Tomohiro Sato, Hideaki Niwa, Shin Sato, Akiko Nakata, Takeshi Sonoda, Noriaki Hashimoto, Ryosuke Namie, Teruki Honma, Takashi Umehara, Mikako Shirouzu, Hiroo Koyama, Minoru Yoshida, Akihiro Ito, Fumiyuki Shirai
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 66 Issue: 6 Pages: 4059-4085
- DOI
  10.1021/acs.jmedchem.2c02059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KJ2790, KAKENHI-PROJECT-19H05640, KAKENHI-PLANNED-23H04882, KAKENHI-PROJECT-23H05473
[Journal Article] Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis2023
- Author(s)
  Okuda, K. et al.,
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 621-621
- DOI
  10.1038/s41467-023-36232-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19380, KAKENHI-PROJECT-20H00543, KAKENHI-PROJECT-19H02841, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-23K17374, KAKENHI-PROJECT-23K06482, KAKENHI-PROJECT-21K19084, KAKENHI-PROJECT-19H05640, KAKENHI-PUBLICLY-22H05568
[Journal Article] Biotransformation of Morphinone and Its Glutathione Adduct Derived from Morphine by Anaerobic Gut Microbes in Guinea Pigs2022
- Author(s)
  Kumagai Yoshito
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 7 Pages: 968-971
- DOI
  10.1248/bpb.b22-00240
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Essential Amino Acid Intake Is Required for Sustaining Serum Insulin‐Like Growth Factor‐I Levels but Is Not Necessarily Needed for Body Growth2022
- Author(s)
  Nishi H, Uchida K, Saito M, Yamanaka D, Nagata H, Tomoshige H, Miyata I, Ito K, Toyochima Y, Takahashi S-I, Hakuno F, Takenaka A
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 9 Pages: 1523-1523
- DOI
  10.3390/cells11091523
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-21K14826, KAKENHI-PROJECT-22K05488, KAKENHI-PROJECT-19H02916, KAKENHI-PROJECT-23K23793
[Journal Article] Capture of Electrophilic Quinones in the Extracellular Space: Evidence for a Phase Zero Reaction2022
- Author(s)
  Shinkai Yasuhiro、Onose Yusuke、Akiyama Masahiro、Hirose Reiko、Kumagai Yoshito
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 36 Issue: 1 Pages: 23-31
- DOI
  10.1021/acs.chemrestox.2c00223
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H05555, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340, KAKENHI-PUBLICLY-22H04799
[Journal Article] Gut Microbiota Reinforces Host Antioxidant Capacity via the Generation of Reactive Sulfur Species2022
- Author(s)
  Uchiyama J. , Akiyama M., Hase K., Kumagai Y., Kim Y.G.
- Journal Title
  
  Cell Reports
  
  Volume: 38(10) Issue: 10 Pages: 110479-110479
- DOI
  10.1016/j.celrep.2022.110479
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21530, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H03490, KAKENHI-PROJECT-20H00509
[Journal Article] Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells2022
- Author(s)
  Sasaki Kazuki、Suzuki Michihiro、Sonoda Takeshi、Schneider-Poetsch Tilman、Ito Akihiro、Takagi Motoki、Fujishiro Shinya、Sohtome Yoshihiro、Dodo Kosuke、Umehara Takashi、Aburatani Hiroyuki、Shin-ya Kazuo、Nakao Yoichi、Sodeoka Mikiko、Yoshida Minoru
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 29 Issue: 7 Pages: 1153-1161
- DOI
  10.1016/j.chembiol.2022.05.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05019, KAKENHI-PLANNED-18H05503, KAKENHI-PLANNED-19H05744, KAKENHI-PROJECT-23K23481, KAKENHI-ORGANIZER-22H05017, KAKENHI-PROJECT-19H05640
[Journal Article] Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain2022
- Author(s)
  Unoki Takamitsu、Akiyama Masahiro、Shinkai Yasuhiro、Kumagai Yoshito、Fujimura Masatake
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 47 Issue: 1 Pages: 31-37
- DOI
  10.2131/jts.47.31
- NAID
  130008139752
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-21K06572, KAKENHI-PROJECT-19K16368
[Journal Article] Retusone A, a Guaiane-Type Sesquiterpene Dimer from Wikstroemia retusa and Its Inhibitory Effects on Histone Acetyltransferase HBO1 Expression2022
- Author(s)
  Yun Young Sook、Nakano Tomomi、Fukaya Haruhiko、Hitotsuyanagi Yukio、Nakamura Miho、Umetsu Megumi、Matsushita Nobuko、Miyake Katsunori、Fuchino Hiroyuki、Kawahara Nobuo、Moriya Fuki、Ito Akihiro、Takahashi Yuji、Inoue Hideshi
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 9 Pages: 2909-2909
- DOI
  10.3390/molecules27092909
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06618, KAKENHI-PROJECT-19H05640
[Journal Article] Redox Homeostasis is Disturbed by Redox Cycling between Reactive Cysteines of Thioredoxin 1 and 9,10-Phenanthrenequinone, an Atmospheric Electron Acceptor2022
- Author(s)
  Abiko Yumi、Taguchi Keiko、Hisamori Miwa、Hiyoshi-Arai Kyoko、Luong Nho Cong、Toriba Akira、Kumagai Yoshito
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 35 Issue: 8 Pages: 1425-1432
- DOI
  10.1021/acs.chemrestox.2c00174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12180, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-23K25015
[Journal Article] Glyceraldehyde 3-phosphate dehydrogenase converts methylmercury to its sulfur adduct with lowered toxicity through sulfane sulfur atoms on Cys2472022
- Author(s)
  Abiko Yumi、Yoshida Eiko、Kumagai Yoshito
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 9 Issue: 1 Pages: 1-5
- DOI
  10.2131/fts.9.1
- NAID
  130008141887
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation2022
- Author(s)
  Tokuyama T、Uosaki H、Sugiura A、Nishitai G、Takeda K、Nagashima S、Shiiba I、Ito N、Amo T、Mohri S、Nishimura A、Nishida M、Konno A、Hirai H、Ishido S、Yoshizawa T、Shindo T、Takada S、Kinugawa S、Inatome R、Yanagi S
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 7 Pages: 104582-104582
- DOI
  10.1016/j.isci.2022.104582
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07878, KAKENHI-PROJECT-21K06844, KAKENHI-PROJECT-22K19754, KAKENHI-PROJECT-22K15399, KAKENHI-PROJECT-19KK0219, KAKENHI-PLANNED-21H05269, KAKENHI-PUBLICLY-22H05574, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H03454, KAKENHI-PROJECT-21H03360, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-19K22791, KAKENHI-PROJECT-23K24334, KAKENHI-PROJECT-22K06454
[Journal Article] Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress2022
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Aoki Hanako、Nishimura Akiyuki、Shinkai Yasuhiro、Warabi Eiji、Nishiyama Kazuhiro、Furumoto Yuka、Anzai Naohiko、Akaike Takaaki、Nishida Motohiro、Kumagai Yoshito
- Journal Title
  
  Redox Biology
  
  Volume: 57 Pages: 102514-102514
- DOI
  10.1016/j.redox.2022.102514
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06572, KAKENHI-PROJECT-22K19395, KAKENHI-PROJECT-22K19397, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05269, KAKENHI-PUBLICLY-22H05555, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-21H03065, KAKENHI-PUBLICLY-22H04799, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277
[Journal Article] Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns2022
- Author(s)
  Chhipi-Shrestha Jagat K.、Schneider-Poetsch Tilman、Suzuki Takehiro、Mito Mari、Khan Khalid、Dohmae Naoshi、Iwasaki Shintaro、Yoshida Minoru
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 29 Issue: 2 Pages: 259-275
- DOI
  10.1016/j.chembiol.2021.07.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15420, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K22406
[Journal Article] Phytochemicals to regulate oxidative and electrophilic stress through Nrf2 activation2022
- Author(s)
  Abiko Yumi、Toriba Akira、Kumagai Yoshito
- Journal Title
  
  Redox Experimental Medicine
  
  Volume: 2023 Issue: 1
- DOI
  10.1530/rem-22-0021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12180, KAKENHI-PROJECT-18H05293
[Journal Article] A Convenient Assay to Detect Protein Oxidation Caused by Redox-Active Quinones2022
- Author(s)
  Luong Nho Cong、Abiko Yumi、Aoki Hanako、Kumagai Yoshito
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 6 Pages: 798-802
- DOI
  10.1248/bpb.b22-00080
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-06-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Long-Acting Thioredoxin Ameliorates Doxorubicin-Induced Cardiomyopathy via Its Anti-Oxidative and Anti-Inflammatory Action2022
- Author(s)
  Murata Ryota、Watanabe Hiroshi、Nosaki Hiroto、Nishida Kento、Maeda Hitoshi、Nishida Motohiro、Maruyama Toru
- Journal Title
  
  Pharmaceutics
  
  Volume: 14 Issue: 3 Pages: 562-562
- DOI
  10.3390/pharmaceutics14030562
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-19H03383, KAKENHI-PLANNED-21H05269
[Journal Article] A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.2022
- Author(s)
  Shimauchi T, Numaga-Tomita T, Kato Y, Morimoto H, Sakata K, Matsukane R, Nishimura A, Nishiyama K, Shibuta A, Horiuchi Y, Kurose H, Kim SG, Urano Y, Ohshima T, Nishida M.
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 13 Pages: 2041-2041
- DOI
  10.3390/cells11132041
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06646, KAKENHI-PROJECT-22K19395, KAKENHI-PLANNED-21H05208, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05269, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21H02607, KAKENHI-PROJECT-19K07116, KAKENHI-PROJECT-23K24035
[Journal Article] Concentrations of nucleophilic sulfur species in small Indian mongoose (Herpestes auropunctatus) in Okinawa, Japan2022
- Author(s)
  Horai Sawako、Abiko Yumi、Unoki Takamitsu、Shinkai Yasuhiro、Akiyama Masahiro、Nakata Katsushi、Kunisue Tatsuya、Kumagai Yoshito
- Journal Title
  
  Chemosphere
  
  Volume: 295 Pages: 133833-133833
- DOI
  10.1016/j.chemosphere.2022.133833
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage2022
- Author(s)
  Liu Jun、Kasai Shuya、Tatara Yota、Yamazaki Hiromi、Mimura Junsei、Mizuno Seiya、Sugiyama Fumihiro、Takahashi Satoru、Sato Tsubasa、Ozaki Taku、Tanji Kunikazu、Wakabayashi Koichi、Maeda Hayato、Mizukami Hiroki、Shinkai Yasuhiro、Kumagai Yoshito、Tomita Hirofumi、Itoh Ken
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 6 Pages: 3201-3201
- DOI
  10.3390/ijms23063201
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21K08432, KAKENHI-ORGANIZER-21H05258, KAKENHI-PUBLICLY-22H05555, KAKENHI-PROJECT-20H04340, KAKENHI-PUBLICLY-22H04799
[Journal Article] Recognition of pathogen-derived sphingolipids in Arabidopsis2022
- Author(s)
 Kato H.、Nemoto K.、Shimizu M.、Abe A.、Asai S.、Ishihama N.、Matsuoka S.、Daimon T.、Ojika M.、Kawakita K.、Onai K.、Shirasu K.、Yoshida M.、Ishiura M.、Takemoto D.、Takano Y.、Terauchi R.
- Journal Title
 
 Science
 
 Volume: 376 Issue: 6595 Pages: 857-860
- DOI
 10.1126/science.abn0650
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-21H05032, KAKENHI-PROJECT-20H02995, KAKENHI-PROJECT-20K15528, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640
[Journal Article] Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain2022
- Author(s)
  Nomura Ryosuke、Takasugi Nobumasa、Hiraoka Hideki、Iijima Yuta、Iwawaki Takao、Kumagai Yoshito、Fujimura Masatake、Uehara Takashi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 23 Pages: 15412-15412
- DOI
  10.3390/ijms232315412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-20K07014
[Journal Article] Potentiation of methylmercury toxicity by combined metal exposure: in vitro and in vivo models of a restricted metal exposome2022
- Author(s)
  Akiyama M., Shinkai Y., Yamakawa H., Kim Y.G., Kumagai Y.
- Journal Title
  
  Chemosphere
  
  Volume: - Pages: 134374-134374
- DOI
  10.1016/j.chemosphere.2022.134374
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21530, KAKENHI-PROJECT-20H03490, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-18H05293
[Journal Article] Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors2022
- Author(s)
  橋本公佑、井手聡一郎、新真由美、中田明子、伊藤昭博、伊藤孝、工藤紀雄、伊藤昭博、伊藤孝、林邦忠、布村一人、津金沢恵子、吉田稔、長岡康夫、住吉孝明
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 13 Issue: 7 Pages: 1077-1082
- DOI
  10.1021/acsmedchemlett.2c00081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H04922, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640
[Journal Article] Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression2022
- Author(s)
  Nishiyama Kazuhiro、Nishimura Akiyuki、Shimoda Kakeru、Tanaka Tomohiro、Kato Yuri、Shibata Takahiro、Tanaka Hiroshi、Kurose Hitoshi、Azuma Yasu-Taka、Ihara Hideshi、Kumagai Yoshito、Akaike Takaaki、Eaton Philip、Uchida Koji、Nishida Motohiro
- Journal Title
  
  Science Signaling
  
  Volume: 15 Issue: 716 Pages: 716-716
- DOI
  10.1126/scisignal.abj0644
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07085, KAKENHI-PROJECT-20K21496, KAKENHI-PROJECT-20K16008, KAKENHI-PLANNED-21H05263, KAKENHI-PLANNED-21H05269, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-19H03383, KAKENHI-PROJECT-19J20086, KAKENHI-PROJECT-22K06646, KAKENHI-ORGANIZER-21H05258, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-22H00356
[Journal Article] The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice2021
- Author(s)
  Abiko Yumi、Katayama Yusuke、Zhao Wenyang、Horai Sawako、Sakurai Kenji、Kumagai Yoshito
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1
- DOI
  10.1038/s41598-021-96579-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Activation of PTP1B/EGFR signaling and cytotoxicity during combined exposure to ambient electrophiles in A431 cells2021
- Author(s)
  Abiko Yumi、Kurosawa Kohki、Yamakawa Hiroto、Kumagai Yoshito
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 4 Pages: 177-185
- DOI
  10.2131/jts.46.177
- NAID
  130008020939
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20K12180
[Journal Article] Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts2021
- Author(s)
  Abiko Yumi、Katayama Yusuke、Akiyama Masahiro、Kumagai Yoshito
- Journal Title
  
  Food and Chemical Toxicology
  
  Volume: 150 Pages: 112061-112061
- DOI
  10.1016/j.fct.2021.112061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20K12180
[Journal Article] Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome2021
- Author(s)
  Abiko Yumi、Aoki Hanako、Kumagai Yoshito
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 413 Pages: 115392-115392
- DOI
  10.1016/j.taap.2020.115392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Dietary lysine restriction induces lipid accumulation in skeletal muscle through an increase in serum threonine levels in rats2021
- Author(s)
  Goda Y, Yamanaka D, Nishi H, Masuda M, Kamei H, Kumano M, Ito K, Katsumata M, Yamanouchi Y, Kataoka N, Hakuno F, Takahashi S-I
- Journal Title
  
  J Biol Chem
  
  Volume: 197 Issue: 4 Pages: 101179-101191
- DOI
  10.1016/j.jbc.2021.101179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation2021
- Author(s)
  Wang Chen、Okita Yukari、Zheng Ling、Shinkai Yasuhiro、Manevich Lev、Chin Jas M.、Kimura Tomokazu、Suzuki Hiroyuki、Kumagai Yoshito、Kato Mitsuyasu
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 10 Pages: 4187-4197
- DOI
  10.1111/cas.15090
- NAID
  120007178942
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07473, KAKENHI-PROJECT-19K07658, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20K20597
[Journal Article] Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain.2021
- Author(s)
  Hiraoka, H., Nomura, R., Takasugi, N., Akai, R., Iwawaki, T., Kumagai, Y., Fujimura, M., and Uehara, T.
- Journal Title
  
  Arch. Toxicol.
  
  Volume: 95 Issue: 4 Pages: 1241-1250
- DOI
  10.1007/s00204-021-02982-9
- NAID
  120007185542
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-20J11445, KAKENHI-PROJECT-19K22498, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-20K07014
[Journal Article] Improved development of mouse somatic cell nuclear transfer embryos by chlamydocin analogues, class I and IIa histone deacetylase inhibitors†2021
- Author(s)
  Kamimura Satoshi、Inoue Kimiko、Mizutani Eiji、Kim Jin-Moon、Inoue Hiroki、Ogonuki Narumi、Miyamoto Kei、Ihashi Shunya、Itami Nobuhiko、Wakayama Teruhiko、Ito Akihiro、Nishino Norikazu、Yoshida Minoru、Ogura Atsuo
- Journal Title
  
  Biology of Reproduction
  
  Volume: 105 Issue: 2 Pages: 543-553
- DOI
  10.1093/biolre/ioab096
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21376, KAKENHI-PLANNED-19H05758, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-19J00238, KAKENHI-PROJECT-20K15697, KAKENHI-PLANNED-19H05751
[Journal Article] Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota2021
- Author(s)
  Seki N, Akiyama M, Yamakawa H, Hase K, Kumagai Y, Kim YG
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 2 Pages: 91-97
- DOI
  10.2131/jts.46.91
- NAID
  130007980544
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21530, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H03490
[Journal Article] Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production via ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells2021
- Author(s)
 Takahashi, M., Kubota, T., Fujie, T., Shinkai, Y., Kumagai, Y., Nakano, T., Hara, T., Yamamoto, C.* and Kaji, T.*
- Journal Title
 
 BPB Reports
 
 Volume: 4 Issue: 6 Pages: 175-181
- DOI
 10.1248/bpbreports.4.6_175
- NAID
 130008115933
- ISSN
 2434-432X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-19K19418, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] Synthesis of reactive sulfur species in cultured vascular endothelial cells after exposure to TGF-β1: Induction of cystathionine γ-lyase and cystathionine β-synthase expression mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 pathways2021
- Author(s)
  37.Takahashi, M., Fujie, T., Nakano, T., Hara, T., Shinkai, Y., Takasawa, R., Hara, Y., Kumagai, Y., Yamamoto, C.* and Kaji, T.*
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 21 Pages: 11762-11762
- DOI
  10.3390/ijms222111762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] Sulfide catabolism ameliorates hypoxic brain injury.2021
- Author(s)
  Marutani E, Morita M, Hirai S, Kai S, Grange RMH, Miyazaki Y, Nagashima F, Traeger L, Magliocca A, Ida T, Matsunaga T, Batten A, Li R, Tanaka T, Ikeda T, Nakagawa A, Atochin DN, Ihara H, Olenchock BA, Shen X, Nishida M, Hanaoka K, Kevil CG, Xian M, Bloch DB, Akaike T, Hindle AG, Motohashi H, Ichinose F, et al.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 3108-3108
- DOI
  10.1038/s41467-021-23363-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21496, KAKENHI-PUBLICLY-20H04767, KAKENHI-PUBLICLY-20H04832, KAKENHI-PUBLICLY-20H05512, KAKENHI-PLANNED-21H05263, KAKENHI-PLANNED-21H05269, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21H04799, KAKENHI-PROJECT-19H03383, KAKENHI-PROJECT-19K07341, KAKENHI-PROJECT-19K07554, KAKENHI-PROJECT-20K07306, KAKENHI-PROJECT-17H06170
[Journal Article] Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor2021
- Author(s)
  Nakahara Kengo、Hamada Kyohei、Tsuchida Tomoki、Takasugi Nobumasa、Abiko Yumi、Shien Kazuhiko、Toyooka Shinichi、Kumagai Yoshito、Uehara Takashi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100524-100524
- DOI
  10.1016/j.jbc.2021.100524
- NAID
  120007116763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-19K22498, KAKENHI-PROJECT-20K07014
[Journal Article] Cysteine Trisulfide Protects E.?coli from Electrophile-Induced Death through the Generation of Cysteine Hydropersulfide2020
- Author(s)
  Henderson Catherine F.、Bica Iris、Long Faith T.、Irwin Drew D.、Stull Christine H.、Baker Blaine W.、Suarez Vega Valeria、Taugher Zachary M.、Fletes Eliza D.、Bartleson Juliet M.、Humphrey Megan L.、?lvarez Luc?a、Akiyama Masahiro、Kumagai Yoshito、Fukuto Jon M.、Lin Joseph
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 33 Issue: 2 Pages: 678-686
- DOI
  10.1021/acs.chemrestox.9b00494
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress2020
- Author(s)
  Unoki Takamitsu、Akiyama Masahiro、Kumagai Yoshito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 2 Pages: 545-545
- DOI
  10.3390/ijms21020545
- NAID
  120007132700
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293
[Journal Article] Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide2020
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Kumagai Yoshito
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 7 Issue: 3 Pages: 161-166
- DOI
  10.2131/fts.7.161
- NAID
  130007840859
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Environmental pollutants and the immune response2020
- Author(s)
  Suzuki Takafumi、Hidaka Takanori、Kumagai Yoshito、Yamamoto Masayuki
- Journal Title
  
  Nature Immunology
  
  Volume: 21 Issue: 12 Pages: 1486-1495
- DOI
  10.1038/s41590-020-0802-6
- NAID
  40022683384
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-20K17336, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-19H05649
[Journal Article] Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B2020
- Author(s)
 Luong Nho Cong、Abiko Yumi、Shibata Takahiro、Uchida Koji、Warabi Eiji、Suzuki Midori、Noguchi Takuya、Matsuzawa Atsushi、Kumagai Yoshito
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 45 Issue: 6 Pages: 349-363
- DOI
 10.2131/jts.45.349
- NAID
 130007851869
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20J20688, KAKENHI-PROJECT-17H06170
[Journal Article] A strategy for repression of arsenic toxicity through nuclear factor E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract2020
- Author(s)
  Abiko Yumi、Okada Miyuki、Aoki Hanako、Mizokawa Mai、Kumagai Yoshito
- Journal Title
  
  Food and Chemical Toxicology
  
  Volume: 145 Pages: 111706-111706
- DOI
  10.1016/j.fct.2020.111706
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Aggregation of β-crystallin through covalent binding to 1,2-naphthoquinone is rescued by α-crystallin chaperone2020
- Author(s)
  Shinkai Yasuhiro、Ding Yunjie、Miura Takashi、Kumagai Yoshito
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 1 Pages: 37-43
- DOI
  10.2131/jts.45.37
- NAID
  130007783941
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Transcriptional induction of cystathionine γ-lyase, a reactive sulfur-producing enzyme, by copper diethyldithiocarbamate in cultured vascular endothelial cells2020
- Author(s)
  Tomoya Fujie, Akane Takahashi, Musubu Takahashi, Takato Hara, Asuka Soyama, Kosho Makino, Hideyo Takahashi, Chika Yamamoto, Yoshito Kumagai, Hiroshi Naka and Toshiyuki Kaji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 17 Pages: 6053-6053
- DOI
  10.3390/ijms21176053
- NAID
  120007163377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-19K16454, KAKENHI-PROJECT-18H05293
[Journal Article] 血液脳関門透過性を有するヒストン脱アセチル化酵素阻害剤の探索.2020
- Author(s)
  住吉孝明、平中誠弥、出口芳春、伊藤昭博、吉田稔
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 30(1) Pages: 43-46
- NAID
  130008033678
- Data Source
  KAKENHI-PROJECT-19H05640
[Journal Article] Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns2020
- Author(s)
  Shrestha Jagat Krishna Chhipi、Schneider-Poetsch Tilman、Suzuki Takehiro、Mito Mari、Khan Khalid、Dohmae Naoshi、Iwasaki Shintaro、Yoshida Minoru
- Journal Title
  
  bioRxiv
  
  Volume: NA
- DOI
  10.1101/2020.11.23.393835
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15420, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640
[Journal Article] Genome-wide survey of ribosome collision.2020
- Author(s)
  Han, P., Shichino, Y., Schneider-Poetsch, T., Mito, M., Hashimoto, S., Udagawa, T., Kohno, K., Yoshida, M., Mishima, Y., Inada, T., Iwasaki, S.
- Journal Title
  
  Cell Rep.
  
  Volume: 31(5) Issue: 5 Pages: 107610-107610
- DOI
  10.1016/j.celrep.2020.107610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H04998, KAKENHI-PROJECT-19K22406, KAKENHI-PLANNED-20H05784
[Journal Article] 阻害剤によるヒストンアセチル化の調節2020
- Author(s)
  高瀬翔平、伊藤昭博、吉田稔
- Journal Title
  
  医学のあゆみ
  
  Volume: 271(1) Pages: 115-122
- Data Source
  KAKENHI-PROJECT-19H05640
[Journal Article] Identification of a selective RelA inhibitor based on DSE-FRET screening methods.2020
- Author(s)
  Shiroma Y, Fujita G, Yamamoto T, Takahashi RU, Kumar A, Zhang KYJ, Ito A, Osada H, Yoshida M, Tahara H.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 21 Issue: 23 Pages: 9150-9150
- DOI
  10.3390/ijms21239150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-19H05640
[Journal Article] Redox Toxicology of Environmental Chemicals Causing Oxidative Stress2020
- Author(s)
  Zheng F., Goncalves FM., Abiko Y., Li H., Kumagai Y., Aschner M.
- Journal Title
  
  Redox Biology
  
  Volume: － Pages: 101475-101475
- DOI
  10.1016/j.redox.2020.101475
- NAID
  120007132623
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15489, KAKENHI-PROJECT-18H05293
[Journal Article] Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors.2020
- Author(s)
  Dileep, K.V., Sakai, N., Ihara, K., Kato-Murayama, M., Nakata, A., Ito, A., Sivaraman, D.M., Shin, J.W., Yoshida, M., Shirouzu M., Zhang, K.Y.J.
- Journal Title
  
  Int. J. Biol. Macromol.
  
  Volume: 170 Pages: 415-423
- DOI
  10.1016/j.ijbiomac.2020.12.118
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640
[Journal Article] S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein2020
- Author(s)
  Fujikawa Kana、Nakahara Kengo、Takasugi Nobumasa、Nishiya Tadashi、Ito Akihiro、Uchida Koji、Uehara Takashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 4 Pages: 910-915
- DOI
  10.1016/j.bbrc.2020.02.011
- NAID
  120006956819
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-20J21060, KAKENHI-PROJECT-19K22498, KAKENHI-PROJECT-17H06170
[Journal Article] Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.2020
- Author(s)
  Radwan, M.O., Ciftci, H.I., Ali, T.F.S., Koga, R., Tateishi, H., Nakata, A., Ito, A., Yoshida, M., Fujita, M., Otsuka, M.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 30(19) Issue: 19 Pages: 127458-127458
- DOI
  10.1016/j.bmcl.2020.127458
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-20H03365
[Journal Article] Repression of mercury accumulation and adverse effects of methylmercury exposure is mediated by cystathionine γ-lyase to produce reactive sulfur species in mouse brain2020
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Yoshida Eiko、Ding Yunjie、Yamakawa Hiroto、Shinkai Yasuhiro、Ishii Isao、Kumagai Yoshito
- Journal Title
  
  Toxicology Letters
  
  Volume: 330 Pages: 128-133
- DOI
  10.1016/j.toxlet.2020.05.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Redox Signaling and Reactive Sulfur Species to Regulate Electrophilic Stress2020
- Author(s)
  Kanda Hironori、Kumagai Yoshito
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 140 Issue: 9 Pages: 1119-1128
- DOI
  10.1248/yakushi.20-00096
- NAID
  130007893808
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Modulation of P2Y6R expression exacerbates pressure overload-induced cardiac remodeling in mice2020
- Author(s)
  Shimoda Kakeru、Nishimura Akiyuki、Sunggip Caroline、Ito Tomoya、Nishiyama Kazuhiro、Kato Yuri、Tanaka Tomohiro、Tozaki-Saitoh Hidetoshi、Tsuda Makoto、Nishida Motohiro
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 13926-13926
- DOI
  10.1038/s41598-020-70956-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07085, KAKENHI-PROJECT-20K16008, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-19H03383, KAKENHI-PROJECT-19J20086, KAKENHI-PROJECT-19K22443
[Journal Article] Sulfane Sulfur in Toxicology: A Novel Defense System Against Electrophilic Stress2019
- Author(s)
  Shinkai Yasuhiro、Kumagai Yoshito
- Journal Title
  
  Toxicological Sciences
  
  Volume: 170 Issue: 1 Pages: 3-9
- DOI
  10.1093/toxsci/kfz091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications.2019
- Author(s)
  Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, Kumagai Y.
- Journal Title
  
  Chem Res Toxicol
  
  Volume: 32 Issue: 3 Pages: 447-455
- DOI
  10.1021/acs.chemrestox.8b00340
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07099, KAKENHI-PUBLICLY-17H05519, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18H05293
[Journal Article] Interaction of Quinone-Related Electron Acceptors with Hydropersulfide Na2S2: Evidence for One-Electron Reduction Reaction2019
- Author(s)
  Abiko Yumi、Nakai Yumi、Luong Nho C.、Bianco Christopher L.、Fukuto Jon M.、Kumagai Yoshito
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 32 Issue: 4 Pages: 551-556
- DOI
  10.1021/acs.chemrestox.8b00158
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-17K15489
[Journal Article] Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload2019
- Author(s)
  Nishimura Akiyuki、Shimoda Kakeru、Tanaka Tomohiro、Toyama Takashi、Nishiyama Kazuhiro、Shinkai Yasuhiro、Numaga-Tomita Takuro、Yamazaki Daiju、Kanda Yasunari、Akaike Takaaki、Kumagai Yoshito、Nishida Motohiro
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 587
- DOI
  10.1126/scisignal.aaw1920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07085, KAKENHI-PROJECT-19K16363, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-19J20086, KAKENHI-PROJECT-18K14921, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-19H03383
[Journal Article] Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules2019
- Author(s)
  Kumagai Yoshito、Akiyama Masahiro、Unoki Takamitsu
- Journal Title
  
  Toxicological Research
  
  Volume: 35 Issue: 4 Pages: 303-310
- DOI
  10.5487/tr.2019.35.4.303
- NAID
  120007127813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293
[Journal Article] Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Shinkai Yasuhiro、Ishii Isao、Ida Tomoaki、Akaike Takaaki、Yamamoto Masayuki、Kumagai Yoshito
- Journal Title
  
  Environmental Health Perspectives
  
  Volume: 127 Issue: 6 Pages: 067002-067002
- DOI
  10.1289/ehp4949
- NAID
  120007133174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18K07099, KAKENHI-PROJECT-18H05277
[Journal Article] MITOL prevemts ER stress-induced apoptosis by IRE1 ubiquitylation at mitochondrial-ER contact sites.2019
- Author(s)
  Takeda, K., Nagashima, S., Shiiba, I., Uda, A., Tokuyama, T., Ito, N., Fukuda, T., Matsushita, N., Ishido, S., Iwawaki, T., Uehara, T., Inatome, R., and Yanagi, S.
- Journal Title
  
  EMBO J.
  
  Volume: 38 Issue: 15
- DOI
  10.15252/embj.2018100999
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22498, KAKENHI-PUBLICLY-18H04869, KAKENHI-PROJECT-17H04053, KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-17K08793, KAKENHI-PROJECT-19K16527
[Journal Article] Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement2019
- Author(s)
  Radwan Mohamed O.、Ciftci Halil I.、Ali Taha F. S.、Ellakwa Doha E.、Koga Ryoko、Tateishi Hiroshi、Nakata Akiko、Ito Akihiro、Yoshida Minoru、Okamoto Yoshinari、Fujita Mikako、Otsuka Masami
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 18 Pages: 3295-3295
- DOI
  10.3390/molecules24183295
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-17H03999
[Journal Article] Attenuation of Macrophage Migration Inhibitory Factor-Stimulated Signaling via S-Nitrosylation2019
- Author(s)
 Nakahara Kengo、Fujikawa Kana、Hiraoka Hideki、Miyazaki Ikuko、Asanuma Masato、Ito Akihiro、Takasugi Nobumasa、Uehara Takashi
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 42 Issue: 6 Pages: 1044-1047
- DOI
 10.1248/bpb.b19-00025
- NAID
 130007657685
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2019-06-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K07993, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-18H05293
[Journal Article] Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells2019
- Author(s)
  Tomoya Fujie, Fukuta Takenaka, Eiko Yoshida, Shuji Yasuike, Yasuyuki Fujiwara, Yasuhiro Shinkai, Yoshito Kumagai, Chika Yamamoto, Toshiyuki Kaji
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 44 Issue: 5 Pages: 327-333
- DOI
  10.2131/jts.44.327
- NAID
  130007642916
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-18H05293
[Journal Article] Identification of ryuvidine as a KDM5A inhibitor.2019
- Author(s)
  Mitsui, E., Yoshida, S., Shinoda, Y., Matsumori, Y., Tsujii, H., Tsuchida, M., Wada, S., Hasegawa, M., Ito, A., Mino, K., Onuki, T., Yoshida, M., Sasaki, R., Mizukami, T.
- Journal Title
  
  Sci. Rep.
  
  Volume: 9(1) Issue: 1 Pages: 9952-9952
- DOI
  10.1038/s41598-019-46346-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-26221204
[Journal Article] Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology2018
- Author(s)
  Fukuto Jon M.、Ignarro Louis J.、Nagy Peter、Wink David A.、Kevil Christopher G.、Feelisch Martin、Cortese-Krott Miriam M.、Bianco Christopher L.、Kumagai Yoshito、Hobbs Adrian J.、Lin Joseph、Ida Tomoaki、Akaike Takaaki
- Journal Title
  
  FEBS Letters
  
  Volume: 592 Issue: 12 Pages: 2140-2152
- DOI
  10.1002/1873-3468.13090
- NAID
  120007133961
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18K07099, KAKENHI-PUBLICLY-17H05519, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-18H04020, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PROJECT-18H05293
[Journal Article] IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line.2018
- Author(s)
  Furuta Haruka, Yoshihara Hidehito, Fukushima Toshiaki, Yoneyama Yosuke, Ito Akihiro, Worrall Claire, Girnita Ada, Girnita Leonard, Yoshida Minoru, Asano Tomoichiro, Komada Masayuki, Kataoka Naoyuki, Chida Kazuhiro, Hakuno Fumihiko, Takahashi Shin-Ichiro
- Journal Title
  
  Oncotarget
  
  Volume: 9(74) Issue: 74 Pages: 33871-33883
- DOI
  10.18632/oncotarget.26049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08625, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-15J10937, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-26221204
[Journal Article] The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems2018
- Author(s)
  Bianco Christopher L、Akaike Takaaki、Ida Tomoaki、Nagy Peter、Bogdandi Virag、Toscano John P、Kumagai Yoshito、Henderson Catherine F、Goddu Robert N、Lin Joseph、Fukuto Jon M
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 176 Issue: 4 Pages: 671-683
- DOI
  10.1111/bph.14372
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18K07099, KAKENHI-PUBLICLY-17H05519, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-18H04020, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PROJECT-18H05293
[Journal Article] Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.2018
- Author(s)
  Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.
- Journal Title
  
  Sci Signal
  
  Volume: 11 Issue: 556 Pages: 5185-5195
- DOI
  10.1126/scisignal.aat5185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-16H05092, KAKENHI-PROJECT-17H04174, KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-17K15464, KAKENHI-PROJECT-17K15483, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-18H05293
[Journal Article] Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation2018
- Author(s)
  Unoki Takamitsu、Akiyama Masahiro、Kumagai Yoshito、Goncalves Filipe Marques、Farina Marcelo、da Rocha Joao Batista Teixeira、Aschner Michael
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 9 Pages: 373-373
- DOI
  10.3389/fgene.2018.00373
- NAID
  120007128084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Preventive Agents and Phytochemicals for Reducing the Adverse Health Effects of Arsenic2018
- Author(s)
  Abiko Yumi、Kumagai Yoshito
- Journal Title
  
  Arsenic Contamination in Asia
  
  Volume: - Pages: 151-161
- DOI
  10.1007/978-981-13-2565-6_9
- ISBN
  9789811325649, 9789811325656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis2018
- Author(s)
  Kawaguchi Hoshimi、Matsumoto Isao、Osada Atsumu、Kurata Izumi、Ebe Hiroshi、Tanaka Yuki、Inoue Asuka、Umeda Naoto、Kondo Yuya、Tsuboi Hiroto、Shinkai Yasuhiro、Kumagai Yoshito、Ishigami Akihito、Sumida Takayuki
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 20 Issue: 1 Pages: 66-66
- DOI
  10.1186/s13075-018-1562-7
- NAID
  120007128092
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Glucose deprivation attenuates sortilin levels in skeletal muscle cells2017
- Author(s)
  Ariga M, Yoneyama Y, Fukushima T, Ishiuchi Y, Ishii T, Sato H, Hakuno F, Nedachi T, Takahashi S
- Journal Title
  
  Endocr J
  
  Volume: 64 Issue: 3 Pages: 255-268
- DOI
  10.1507/endocrj.EJ16-0319
- NAID
  130005529466
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18766, KAKENHI-PROJECT-16K08077, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15H04583
[Journal Article] USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.2017
- Author(s)
  Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 484 Issue: 3 Pages: 522-528
- DOI
  10.1016/j.bbrc.2017.01.101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112003, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15H04583
[Journal Article] Deficiency of X-linked protein kinase Nrk during pregnancy triggers breast tumor in mice2016
- Author(s)
  Yanagawa T, Denda K, Inatani T, Fukushima T, Tanaka T, Kumaki N, Inagaki Y, Komada M
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 186 Issue: 10 Pages: 2751-2760
- DOI
  10.1016/j.ajpath.2016.06.005
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24112003, KAKENHI-PROJECT-15H03526, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-25293179, KAKENHI-PROJECT-26440048, KAKENHI-PROJECT-15K15299, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15K14378
[Journal Article] Efficient N-Acyldopamine Synthesis2016
- Author(s)
  Matsumoto Y, Ito A, Uesugi M, Kittaka A
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: in press
- NAID
  130005160071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26650011
[Journal Article] Phosphatidylinositol 3-Kinase-associated Protein (PI3KAP)/XB130 Crosslinks actin Filaments through its Actin Binding and Multimerization Properties In Vitro and Enhances Endocytosis in HEK293 cells2016
- Author(s)
  Daisuke Yamanaka, Takeshi Akama, Kazuhiro Chida, Shiro Minami, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Journal Title
  
  frontiers in Endocrinology
  
  Volume: 7 Pages: 89-89
- DOI
  10.3389/fendo.2016.00089
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K18812, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583
[Journal Article] Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells.2015
- Author(s)
  Itoh Y, Sawada H, Suzuki M, Tojo T, Sasaki R, Hasegawa M, Mizukami T, Suzuki T
- Journal Title
  
  ACS Med Chem Lett.
  
  Volume: 6 Issue: 6 Pages: 665-670
- DOI
  10.1021/acsmedchemlett.5b00083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640093
[Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF signaling and mitogenic activity.2015
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Jing Luan, Cunming Duan, Yasushi Saeki, Keiji Tanaka, Shun-Ichiro Iemura, TohruNatsume, Kazuhiro Chida, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Journal Title
  
  Nature communications
  
  Volume: 6 Issue: 1 Pages: 6780-6780
- DOI
  10.1038/ncomms7780
- NAID
  120006348510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25850220, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112008, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-26000014
[Journal Article] Rapid increase in fibroblast growth factor 2 in protein malnutrition and its impact on growth and lipid metabolism.2015
- Author(s)
  Yori Ozaki, Kenji Saito, Kyoko Nakazawa, Morichika Konishi, Nobuyuki Itoh, Fumihiko Hakuno, Shin-Ichiro Takahashi, Hisanori Kato and Asako Takenaka
- Journal Title
  
  British Journal of Nutrition
  
  Volume: 114 Issue: 9 Pages: 1410-1418
- DOI
  10.1017/s0007114515002846
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07444, KAKENHI-PROJECT-26460084, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-25221204
[Journal Article] Regulation of Histone Deacetylase 6 Activity via S-Nitrosylation2015
- Author(s)
 Okuda K, Ito A, and Uehara T.
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 38 Issue: 9 Pages: 1434-1437
- DOI
 10.1248/bpb.b15-00364
- NAID
 130005096977
- ISSN
 0918-6158, 1347-5215
- Language
 English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
 KAKENHI-PROJECT-15K14952, KAKENHI-PROJECT-15H04649, KAKENHI-PLANNED-26111008
[Journal Article] The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap12015
- Author(s)
  Ito A, Shimazu T, Maeda S, Shah AA, Tsunoda T, Iemura S, Natsume T, Suzuki T, Motohashi H, Yamamoto M, Yoshida M.
- Journal Title
  
  Science Signaling.
  
  Volume: 8 Issue: 404 Pages: 404-404
- DOI
  10.1126/scisignal.aad0667
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460354, KAKENHI-PLANNED-23116002, KAKENHI-PLANNED-24115007, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-26650011, KAKENHI-PROJECT-26670150
[Journal Article] Kinetic and structural basis for acyl-group selectivity and NAD(+) dependence in sirtuin-catalyzed deacylation2015
- Author(s)
  Feldman, J. L., Dittenhafer-Reed, K. E., Kudo, N., Thelen, J. N., Ito, A., Yoshida, M., and Denu, J. M.
- Journal Title
  
  Biochemistry
  
  Volume: 54 Issue: 19 Pages: 3037-3050
- DOI
  10.1021/acs.biochem.5b00150
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-26650011
[Journal Article] Identification of 1,2,5-Oxadiazoles as a New Class of SENP2 Inhibitors Using Structure Based Virtual Screening.2014
- Author(s)
  Kumar A, Ito A, Takemoto M, Yoshida M, Zhang KY.
- Journal Title
  
  J. Chem. Inf. Model.
  
  Volume: 54 Issue: 3 Pages: 870-880
- DOI
  10.1021/ci4007134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510288
[Journal Article] Discovery of small molecule inhibitors targeting the SUMO-SIM interaction using a protein interface consensus approach2014
- Author(s)
  Voet AR, Ito A, Hirohama M, Matsuoka S, Tochiode N, Kigawa T, Yoshida M, Zhang KY.
- Journal Title
  
  MedChemComm
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510288
[Journal Article] Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata2014
- Author(s)
  M. Takemoto, Y. Kawamura, M. Hirohama, Y. Yamaguchi, H. Handa, H. Saitoh, Y. Nakao, M. Kawada, K. Khalid, H. Koshino, K. Kimura, A. Ito, M. Yoshida
- Journal Title
  
  J. Antibiot. (Tokyo)
  
  Volume: 67 Issue: 4 Pages: 335-338
- DOI
  10.1038/ja.2013.142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23102002, KAKENHI-PROJECT-23510288, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118002
[Journal Article] Assay methods for small ubiquitin-like modifier (SUMO)-SUMO-interacting motif (SIM) interactions in vivo and in vitro using a split-luciferase complementation system2014
- Author(s)
  Hirohama M, Voet AR, Ozawa T, Saitoh H, Nakao Y, Zhang KY, Ito A, Yoshida M.
- Journal Title
  
  Anal Biochem.
  
  Volume: 448 Pages: 92-4
- DOI
  10.1016/j.ab.2013.12.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02509, KAKENHI-PROJECT-21675001, KAKENHI-PROJECT-23510288, KAKENHI-PROJECT-23616004, KAKENHI-PROJECT-26220805
[Journal Article] Identification of sumoylation activating enzyme 1 inhibitors by structure-based virtual screening.2013
- Author(s)
  Kumar A, Ito A, Hirohama M, Yoshida M, Zhang KY.
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 53 Issue: 4 Pages: 809-820
- DOI
  10.1021/ci300618e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510288
[Journal Article] Discovery of small molecule inhibitors targeting the SUMOSIM interaction using a protein interface consensus approach2013
- Author(s)
  Voet A#, Ito A#, Hirohama M, Yoshida M, Zhang KY. #equally contributed
- Journal Title
  
  Medchemcomm.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510288
[Journal Article] Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors.2013
- Author(s)
  Kumar A, Ito A, Hirohama M, Yoshida M, Zhang KY.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 23 Issue: 18 Pages: 5145-5149
- DOI
  10.1016/j.bmcl.2013.07.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510288
[Journal Article] Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2.2013
- Author(s)
  Hirohama M, Kumar A, Fukuda I, Matsuoka S, Igarashi Y, Saitoh H, Takagi M, Shin-ya K, Honda K, Kondoh Y, Saito T, Nakao Y, Osada H, Zhang KY, Yoshida M, Ito A
- Journal Title
  
  ACS Chem Biol
  
  Volume: 8 Issue: 12 Pages: 2635-2642
- DOI
  10.1021/cb400630z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510287, KAKENHI-PROJECT-23510288, KAKENHI-PROJECT-23616004, KAKENHI-PROJECT-221S0001
[Journal Article] Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs2012
- Author(s)
  Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S-I
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 423 Issue: 1 Pages: 122-127
- DOI
  10.1016/j.bbrc.2012.05.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22687009, KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928
[Journal Article] Novel repressor regulates insulin sensitivity through interaction with Foxo12012
- Author(s)
  Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi SI, Itoh H
- Journal Title
  
  EMBO J.
  
  Volume: 31 Issue: 10 Pages: 2275-2295
- DOI
  10.1038/emboj.2012.97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24650442, KAKENHI-PUBLICLY-24116507
[Journal Article] HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells2011
- Author(s)
  Fukushima T, Okajima H, Yamanaka D, Ariga M, Nagata S, Ito A, Yoshida H, Asano T, Chida K
- Journal Title
  
  Mol.Cell Endocrinol.
  
  Volume: 344 Issue: 1-2 Pages: 81-90
- DOI
  10.1016/j.mce.2011.06.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249
[Journal Article] アセチル化2007
- Author(s)
  伊藤昭博
- Journal Title
  
  分子細胞治療 6・1
  
  Pages: 16-22
- Data Source
  KAKENHI-PROJECT-17780087
[Journal Article] アセチル化2007
- Author(s)
  伊藤昭博
- Journal Title
  
  分子細胞治療 6・1
  
  Pages: 16-22
- Data Source
  KAKENHI-PROJECT-17050028
[Presentation] 細胞膜透過性向上を志向したヒドロキサム酸構造を有するpyrilamine型HDAC6阻害剤の探索合成2024
- Author(s)
  天野日菜子、平中誠弥、式田亮史、中田明子、新真由美、伊藤孝、伊藤昭博、吉田稔、布村一人、井手聡一郎、長岡康夫、住吉孝明
- Organizer
  日本薬学会144年会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] 酵母から哺乳類まで寿命を延ばす細菌2024
- Author(s)
  伊藤孝、吉田稔
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] 乳酸がミトコンドリア病様症状を改善する作用機序の解析2023
- Author(s)
  伊藤　孝、西村　はる菜、Nurmila Sari、吉田稔
- Organizer
  第22回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] アシルCoA合成酵素ACSL4のリジン長鎖アシル化による機能変換、2023
- Author(s)
  小瀬章太郎、前本佑樹、大林翼、落合翔、鈴木健裕、堂前直、原俊太郎、伊藤昭博
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] 遺伝性疾患治療を目指したケミカルバイオロジーによるエピゲノム及び代謝リモデリングの制御2023
- Author(s)
  吉田稔、伊藤昭博
- Organizer
  第23回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] 金触媒アミド化反応を用いた標的組織内構築志向型HDAC阻害剤プロドラッグの探索2023
- Author(s)
  橋本公佑、新真由美、中田明子、伊藤孝、伊藤昭博、工藤紀雄、吉田稔、田中克典、長岡康夫、住吉孝明
- Organizer
  日本薬学会143年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] GAS41のYEATSドメインを用いた蛍光プローブの開発2023
- Author(s)
  佐々木和樹、高瀬翔平、菊地正樹、梅原崇史、伊藤昭博、吉田稔
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] Lysine long-chain fatty acylation regulates the TEAD transcription factor in Hippo signaling pathway2023
- Author(s)
  Kota Noritsugu, Takehiro Suzuki, Yasue Ichikawa, Kenji Ohgane, Naoshi Dohmae, Minoru Yoshida, Akihiro Ito
- Organizer
  ChemBioNara2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 環境化学物質によるヒストン修飾を介した遺伝子発現調節2023
- Author(s)
  伊藤昭博
- Organizer
  第50回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] 環境化学物質由来ヒストン修飾によるエピジェネティック制御2023
- Author(s)
  伊藤昭博
- Organizer
  第97回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] 食品添加物が引き起こす翻訳後修飾2023
- Author(s)
  則次恒太、伊藤昭博
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] ドーパミンアシル化酵素としてのPLAATの機能解析2023
- Author(s)
  前田萌羽、前本佑樹、_木元秀、廣田瑛紀、宇山徹、平島真一、梅村知也、上田夏生、吉田稔、伊藤昭博
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] リジン_鎖アシル化修飾を介した転写因子TEADの活性制御2023
- Author(s)
  則次恒太、鈴木健裕、市川保恵、小川健司、堂前直、吉田稔、伊藤昭博
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] リジン長鎖アシル化修飾による転写因子の活性制御2023
- Author(s)
  伊藤昭博
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] 生活環境由来カルボン酸が引き起こす新規ヒストンリジンアシル化修飾の探索2023
- Author(s)
  青木康明、則次恒太、高瀬翔平、勝間蒼衣、鈴木健裕、熊谷嘉人、堂前直、伊藤昭博
- Organizer
  日本毒性学会付加体科学部会第１回キックオフシンポジウム
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] ヒストンメチル化酵素SETDB1の阻害剤探索2023
- Author(s)
  加藤孝大、前本佑樹、_原いく、園田健、出井晶子、_田裕之、眞貝洋一、吉田稔、伊藤昭博
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] Lactate inhibits glycolysis and attenuates mitochondrial disease2023
- Author(s)
  伊藤孝、西村はる菜、Nurmila Sari、小林大貴、吉田稔
- Organizer
  理研‐早稲田シンポジウム2023 ~化学と微生物の接点~
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] Exploration of novel histone lysine acyl modifications induced by carboxylic acids from the living environment2023
- Author(s)
  Komei Aoki, Kota Noritsugu, Shohei Takase, Yuki Shimizu, Ai Katsuma, Takehiro Suzuki, Naoshi Dohmae, Akihiro Ito
- Organizer
  The 10th International Congress of Asian Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] 長鎖アシルCoA合成酵素リジン長鎖アシル化による機能変換2023
- Author(s)
  前本佑樹、大林翼、小_章太郎、落合翔、鈴木健裕、堂前直、原俊太郎、伊藤昭博
- Organizer
  第33回新薬創製談話会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] がん原遺伝子Fynのリジン長鎖アシル化の解析2023
- Author(s)
  箱田美沙希、前本佑樹、則次恒太、鈴木健裕、堂前直、伊藤昭博
- Organizer
  第33回新薬創製談話会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] ヒストンメチル化酵素G9aの阻害剤による体細胞クローン法の改善2023
- Author(s)
  的場章悟、四方大樹、黒滝陽子、白井文幸、山田祐子、渡邉奈緒美、伊藤昭博、眞貝洋一、佐々木えりか、吉田稔、小倉　淳郎
- Organizer
  第70回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] 外来性カルボン酸由来新規ヒストンリジンアシル化修飾の探索2023
- Author(s)
  青木康明、則次恒太、高瀬翔平、清水勇希、鈴木健裕、堂前直、伊藤昭博
- Organizer
  日本ケミカルバイオロジー学会　第17回年会
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] Elucidation of molecular mechanism underlying the antagonistic roles of class I and II RPD3-like histone deacetylases in response to environmental stresses2023
- Author(s)
  Ueda Minoru, Ito Akihiro, Suzuki Takehiro,Takahashi Satoshi, Tanaka Maho, Ishida Junko, Dohmae Naoshi, Yoshida Minoru, Seki Motoaki
- Organizer
  The 33rd International Conference on Arabidopsis Research (ICAR2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] 解糖系酵素PFK1新規阻害剤TLAMはSAMP8マウスの空間認知記憶改善に寄与する2023
- Author(s)
  伊藤孝、西村　はる菜、川村りか、吉田　稔
- Organizer
  第38回老化促進モデルマウス（SAM）学会学術大会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] FATP2のリジン長鎖アシル化による脂質代謝調節2023
- Author(s)
  大林翼、前本佑樹、落合翔、小瀬章太郎、鈴木健裕、堂前直、原俊太郎、伊藤昭博
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] 生活環境由来カルボン酸による付加体形成　―エピジェネティクスに与える影響―2023
- Author(s)
  伊藤昭博
- Organizer
  日本毒性学会付加体科学部会第１回キックオフシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] 抗がん剤創製を目指したヒストンメチル化酵素 G9a 阻害剤の開発2023
- Author(s)
  伊藤昭博、吉田稔
- Organizer
  第27回がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23H05473
[Presentation] 環境化学物質によるヒストン付加体形成とエピジェネティック制御2023
- Author(s)
  伊藤昭博
- Organizer
  日本薬学会第144年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] 新規N-アシルドーパミン合成酵素の発見2022
- Author(s)
  前田萌羽、前本佑樹、青木元秀、梅村知也、吉田稔、伊藤昭博
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Hippo経路におけるYAP-TEAD間相互作用を標的とした阻害剤探索研究2022
- Author(s)
  関根咲彩、高瀬翔平、則次恒太、黒川留美、市川保恵、小川健司、松本健、長田裕之、吉田稔、伊藤昭博
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Environmental stress-induced aberrant mitochondrial fission underlies cardiac vulnerability to mechanical load through Drp1 depolysulfidation2022
- Author(s)
  Akiyuki Nishimura, Kakeru Shimoda, Xiaokang Tang, Kazuhiro Nishiyama, Yuri Kato, Yuko Ibuki, Takaaki Akaike, Yoshito Kumagai, Motohiro Nishida
- Organizer
  4th International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Redox-dependent alternative internalization (REDAI) of GPCRs2022
- Author(s)
  Kazuhiro Nishiyama, Akiyuki Nishimura, Kakeru Shimoda, Yuri Kato, Yoshito Kumagai, Takaaki Akaike, Philip Eaton, Koji Uchida, Motohiro Nishida
- Organizer
  The 12th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] ヒストンメチル化酵素 G9a 阻害剤 RK-701 による白血病細胞の増殖抑制機構 .2022
- Author(s)
  高瀬翔平、大石智一、大庭俊一、川田学、吉田稔、伊藤昭博
- Organizer
  第26回がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Pateamine A mediates selective translational repression by anchoring eIF4A to GNG motifs2022
- Author(s)
  Saito Hironori, Chen Mingming, Schneider-Poetsch Tilman, Shichino Yuichi, Romo Daniel, F_rstner Alois, Yoshida Minoru, Iwasaki Shintaro
- Organizer
  Cold spring harbor Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] N-アシルドーパミン合成酵素の発見2022
- Author(s)
  前田萌羽、前本佑樹、青木元秀、宇山徹、梅村知也、上田夏生、吉田稔、伊藤昭博
- Organizer
  第45回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Proteins from translated introns repress global protein synthesis2022
- Author(s)
  Jagat K. Chhipi-Shrestha, Tilman Schneider-Poetsch, Takehiro Suzuki, Mari Mito, Khalid Khan, Naoshi Dohmae, Shintaro Iwasaki and Minoru Yoshida
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 鎌状赤血球症治療薬創製を目指したヒストンメチル化酵素 G9a 阻害剤の開発2022
- Author(s)
  伊藤昭博、高瀬翔平、寛山隆、白井文幸、西ヶ谷洋輔、角谷龍展、中田明子、園田健、丹羽英明、梅原崇史、中村幸夫、吉田稔
- Organizer
  日本ケミカルバイオロジー学会　第16回年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 外来性カルボン酸由来の新規ヒストンリジンアシル化修飾の探索2022
- Author(s)
  青木康明、則次恒太、鈴木健裕、堂前直、伊藤昭博
- Organizer
  第32回新薬創製談話会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 新規ドーパミンアシル基転移酵素の同定2022
- Author(s)
  前本佑樹、前田萌羽、青木元秀、宇山徹、梅村知也、上田夏生、吉田稔、伊藤昭博
- Organizer
  第64回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] リジン長鎖アシル化修飾による転写因子 TEAD の機能制御機構の解析2022
- Author(s)
  則次恒太、堂前直、吉田稔、伊藤昭博
- Organizer
  第26回がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] ソルビン酸により惹起されるヒストンリジンソルビル化修飾による遺伝子発現制御2022
- Author(s)
  清水勇希、則次恒太、鈴木健裕、小池晃太、どど孝介、袖岡幹子、堂前直、伊藤昭博
- Organizer
  第15回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 転写因子TEADの新規翻訳後修飾リジン長鎖アシル化2022
- Author(s)
  鈴木健裕、則次恒太、伊藤昭博、堂前直
- Organizer
  日本プロテオーム学会2022年大会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] YAP-TEADの分子間相互作用を標的とした阻害剤探索2022
- Author(s)
  関根咲彩、高瀬翔平、林瀬瑠奈、則次恒太、黒川留美、市川保恵、近藤恭光、小川健司、松本健、長田裕之、吉田稔、伊藤昭博
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Pateamine A mediates selective translational repression by anchoring eIF4A to GNG motifs2022
- Author(s)
  Saito Hironori, Chen Mingming, Schneider-Poetsch Tilman, Shichino Yuichi, Romo Daniel, F_rstner Alois, Yoshida Minoru, Iwasaki Shintaro
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 食品添加物に特化した限定エクスポソーム研究2022
- Author(s)
  伊藤昭博
- Organizer
  第49回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] YAP-TEAD 間相互作用を標的とした Hippo 経路阻害剤の開発2022
- Author(s)
  関根咲彩、高瀬翔平、則次恒太、松本健、長田裕之、吉田稔、伊藤昭博
- Organizer
  第26回がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] システインパルミトイル化によるリジン脱アセチル化酵素SIRT1の活性制御2022
- Author(s)
  則次恒太、玉田南、鈴木健裕、堂前直、伊藤昭博
- Organizer
  第45回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 外来性親電子物質によるエピゲノム調節を介した遺伝子発現変化2022
- Author(s)
  土田知貴、高杉展正、伊藤昭博、熊谷嘉人、上原孝
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Pateamine A mediates selective translational repression by anchoring eIF4A to GNG motifs2022
- Author(s)
  Saito Hironori, Chen Mingming, Schneider-Poetsch Tilman, Shichino Yuichi, Romo Daniel, F_rstner Alois, Yoshida Minoru, Iwasaki Shintaro
- Organizer
  Cold spring harbor Translational Control 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Mechanism of cardiomyocytes aging due to cigarette sidestream smoke2022
- Author(s)
  Xiaokang Tang, Akiyuki Nishimura, Kazuhiro Nishiyama, Yuri Kato, Yuko Ibuki, Takaaki Akaike, Yoshito Kumagai, Motohiro Nishida
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Lacate inhibits glycolysis and attenuates mitochondrial disease2022
- Author(s)
  Ito Takashi, Nishimura Haruna, Nurmila Sari, Kobayashi Hiroki, Yoshida Minoru
- Organizer
  Cell Symposia: Multifaceted Mitochondria
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] YAP-TEAD間相互作用を阻害する低分子化合物の探索2021
- Author(s)
  3.関根咲彩、高瀬翔平、林瀬瑠奈、則次恒太、市川保恵、近藤恭光、小川健司、長田裕之、吉田稔、伊藤昭博
- Organizer
  2021年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] 転写因子 TEAD の転写活性を制御する新規翻訳後修飾リジン長鎖アシル化の解析2021
- Author(s)
  則次恒太、堂前直、吉田稔、伊藤昭博
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Function and regulation of novel lysine acyl modifications2021
- Author(s)
  Akihiro Ito
- Organizer
  The Kick-off Symposium of Core-to-Core International Collaboration
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] mTOR経路阻害でリー脳症モデルNdufs4 KOマウス寿命を延長する分子機構2021
- Author(s)
  伊藤孝、小林大貴、吉田稔
- Organizer
  J-mit 特別オンラインシンポジウム
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] YAP-TEAD間相互作用を標的とした低分子阻害剤の探索2021
- Author(s)
  12.関根咲彩、高瀬翔平、林瀬瑠奈、則次恒太、市川保恵、近藤恭光、小川健司、長田裕之、吉田稔、伊藤昭博
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] ケミカルバイオロジー研究から見出されたリジンアシル化修飾研究の新展開2021
- Author(s)
  伊藤昭博
- Organizer
  発生工学研究センターセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22271
[Presentation] YAP-TEADの分子間相互作用を標的とした阻害剤探索2021
- Author(s)
  19.関根咲彩、高瀬翔平、林瀬瑠奈、則次恒太、黒川留美、市川保恵、近藤恭光、小川健司、松本健、長田裕之、吉田稔、伊藤昭博
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] タンパク質アシル化の同定を指向したアルキン修飾ペプチド直接濃縮法の開発2021
- Author(s)
  小池晃太、どど孝介、則次恒太、伊藤昭博、袖岡幹子
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] リジン長鎖アシル化修飾の新規機能2021
- Author(s)
  伊藤昭博
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] YAP-TEAD分子間相互作用を標的とした阻害剤スクリーニング2021
- Author(s)
  高瀬翔平、関根咲彩、林瀬瑠奈、則次恒太、市川保恵、近藤恭光、小川健司、長田裕之、吉田稔、伊藤昭博
- Organizer
  日本ケミカルバイオロジー学会　第15回年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] YAP-TEAD分子間相互作用を標的とした阻害剤スクリーニング2021
- Author(s)
  2.高瀬翔平、関根咲彩、林瀬瑠奈、則次恒太、市川保恵、近藤恭光、小川健司長田裕之、吉田稔、伊藤昭博
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] 転写因子TEADの転写活性を制御する新規翻訳後修飾リジン長鎖アシル化の解析2021
- Author(s)
  則次恒太、堂前直、吉田稔、伊藤昭博
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] リジン長鎖アシル化修飾の新規機能2021
- Author(s)
  伊藤昭博
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] ケミカルバイオロジー研究から見出されたリジンアシル化修飾研究の新展開2021
- Author(s)
  伊藤昭博
- Organizer
  発生工学研究センターセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Nrf2 and CSE: Two sides of the same coin in protection against electrophilic stress as a category of oxidative stress2021
- Author(s)
  Kumagai Yoshito
- Organizer
  The Society of Toxicology’s 59th Annual Meeting: The SOT/JSOT Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 機能低下したミトコンドリアを活性化させる化合物の発見とその応用2021
- Author(s)
  小林大貴、畠山英之、伊藤孝、西村はる菜、横田睦美、鈴木禎史、苫米地由里、白水美香子、長田裕之、三牧正和、後藤雄一、吉田稔
- Organizer
  J-mit 特別オンラインシンポジウム
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] メタボローム解析でわかるアミノ酸シグナルが肝細胞の脂肪蓄積に果たす役割2021
- Author(s)
  山中大介, 増田正人, 西宏起, 合田祐貴, 伯野史彦, 高橋伸一郎, 伊藤公一
- Organizer
  日本分子細胞生物学会ワークショップ 3AW-13「統合的な栄養学研究で紡ぐ次世代栄養学」
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] リジンアシル化修飾研究からリジンアダクトエキスポソームへ2021
- Author(s)
  伊藤昭博
- Organizer
  第94回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] リジン長鎖アシル化修飾の新規機能2021
- Author(s)
  伊藤昭博
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22271
[Presentation] Adaptive response and protection against electrophilic stress2021
- Author(s)
  Kumagai Yoshito
- Organizer
  The 24th SANKEN International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Function and regulation of novel lysine acyl modifications2021
- Author(s)
  Akihiro Ito
- Organizer
  The Kick-off Symposium of Core-to-Core International Collaboration
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] Adaptive response and protection against electrophilic stress2020
- Author(s)
  Kumagai Yoshito
- Organizer
  The 1st International Virtual Forum on Modern Toxicology: A2020 Vision
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] リジン長鎖アシル化修飾による転写制御2020
- Author(s)
  伊藤昭博
- Organizer
  日本薬学会第140年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] Hippo経路におけるYAP-TEAD相互作用を標的とした阻害剤探索2020
- Author(s)
  高瀬翔平、長田裕之、吉田稔、伊藤昭博
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] リジン長鎖アシル化修飾による転写制御2020
- Author(s)
  伊藤昭博
- Organizer
  日本薬学会第140年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] TEAD-YAP相互作用を標的とした化合物の探索2020
- Author(s)
  高瀬翔平、林瀬瑠奈、則次恒太、市川保恵、小川健司、吉田稔、伊藤昭博
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-19K22271
[Presentation] ケミカルバイオロジー研究から見出されたリジンアシル化修飾研究の新展開2020
- Author(s)
  伊藤昭博
- Organizer
  発生工学研究センターセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] リジンアシル化修飾研究の新展開　－食品成分カルボン酸によるリジンアダクトエクスポソームの可能性－2020
- Author(s)
  伊藤昭博
- Organizer
  第47回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] エピジェネティクスリーダータンパク質GAS41の阻害剤探索2020
- Author(s)
  高瀬翔平、高橋未帆、園田健、菊地正樹、近藤恭光、梅原崇史、長田裕之、吉田稔、伊藤昭博
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] ハイプシン化阻害剤GC7のミトコンドリアへの影響2020
- Author(s)
  松本健、黒川留美、Tariq Mohammad、Schneider-Poetsch Tilman、凌楓、室井誠、鈴木健裕、堂前直、伊藤昭博、長田裕之、吉田稔
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Hippo経路におけるYAP-TEAD相互作用を標的とした阻害剤探索2020
- Author(s)
  高瀬翔平、長田裕之、吉田稔、伊藤昭博
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22271
[Presentation] TEAD-YAP相互作用を標的とした化合物の探索2020
- Author(s)
  高瀬翔平、林瀬瑠奈、則次恒太、市川保恵、小川健司、吉田稔、伊藤昭博
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns2020
- Author(s)
  Chhipi Shrestha Jagat Krishna, Schneider-Poetsch Tilman, Suzuki Takehiro, Mito Mari, Khan Khalid, Dohmae Naoshi, Iwasaki Shintaro, Yoshida Minoru
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Hippo経路におけるYAP-TEAD相互作用を標的とした阻害剤探索2020
- Author(s)
  高瀬翔平、長田裕之、吉田稔、伊藤昭博、
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] リジン長鎖アシル化修飾による転写制御2020
- Author(s)
  伊藤昭博
- Organizer
  日本薬学会第140年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22271
[Presentation] eIF5Aハイプシン化阻害剤GC7によるミトコンドリアタンパク質の減少2019
- Author(s)
  松本健、黒川留美、Tariq Mohammad、Schneider-Poetsch Tilman、凌楓、室井誠、鈴木健裕、堂前直、伊藤昭博、長田裕之、吉田稔
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Molecular Mechanism of Methylmercury-Induced Neurotoxicity via Endoplasmic Reticulum Stress2019
- Author(s)
  Hideki Hiraoka, Kengo Nakahara, Nobumasa Takasugi, Masatake Fujimura, Takao Iwawaki, Yoshito Kumagai, Takashi Uehara
- Organizer
  IUTOX ICTXV 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02579
[Presentation] Development of fluorescent probes for visualizing an interaction between intra-nucleosomal histone H3 K9 tri-methylation and HP1α chromodomain and live-cell imaging2019
- Author(s)
  Kazuki Sasaki, Michihiro Suzuki, Akihiro Ito, Yoichi Nakao, Minoru Yoshida
- Organizer
  2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] The role of lysine long-chain fatty acylation of TEAD transcription factors for transcriptional output of Hippo signaling pathway2019
- Author(s)
  Kota Noritsugu, Kenji Ogawa, Takehiro Suzuki, Naoshi Dohmae, Minoru Yoshida, Akihiro Ito
- Organizer
  FASEB Science Research Conference: Reversible Protein Acetylation in Health and Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] Identification, characterization and a three-dimensional structure modeling of metallothionein-3 as a sulfane sulfur- and zinc-binding protein.2019
- Author(s)
  Shinkai Yasuhiro、Yunjie Ding、Akiyama Masahiro、Unoki Takamitsu、Ida Tomoaki、Akaike Takaaki、Jon M. Fukuto、Kumagai Yoshito
- Organizer
  The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Rbfox2 protein mediates exon 11 inclusion in insulin receptor alternative splicing in hepatoma cells2019
- Author(s)
  Naoyuki Kataoka, Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Regulation of Ubiquitin-Proteasome System in ERAD via S-nitrosylation of UBE2D1.2019
- Author(s)
  Kana Fujikawa, Kengo Nakahara, Nobumasa Takasugi, Akihiro Ito, Takashi Uehara
- Organizer
  IUTOX ICTXV 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02579
[Presentation] リジン鎖アシル化タンパク質の網羅的な探索法の開発2019
- Author(s)
  加藤竜、則次恒太、鈴木健裕、堂前直、吉田稔、伊藤昭博
- Organizer
  第24 回化学生物学研究会
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] Identification and characterization of metallothionein-3 as a pesulfide binding protein2019
- Author(s)
  Yunjie Ding、Shinaki Yasuhiro、Kumagai Yoshito
- Organizer
  Society of Toxicology 58th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE act as critical molecules in parallel pathways for regulation of electrophilic stress in mice2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Shinkai Yasuhiro、Ishii Isao、Jon M Fukuto、Akaike Takaaki、Yamamoto Masayuki、Kumagai Yoshito
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] “The role of lysine long-chain fatty acylation of TEAD transcription factors for transcriptional output of Hippo signaling pathway”2019
- Author(s)
  Kota Noritsugu, Kenji Ogawa, Takehiro Suzuki, Naoshi Dohmae, Minoru Yoshida, Akihiro Ito,
- Organizer
  FASEB Science Research Conference, Reversible Acetylation on Health and Disease (HDACs)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22271
[Presentation] Unique adaptive response to electrophilic stress2019
- Author(s)
  Kumagai Yoshito
- Organizer
  Seminar on biovailability of arsenic at Department of Toxicology of Zhejiang University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE act as critical molecules in parallel pathways for repression of environmental electrophile-mediated toxicity in mice.2019
- Author(s)
  Shinakai Yasuhiro、Yunjie Ding、Akiyama Masahiro、Jon M Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 一酸化窒素によるユビキチン結合酵素UBE2D1活性調節機構2019
- Author(s)
  藤河香奈，中原健吾，高杉展正，伊藤昭博，上原孝
- Organizer
  日本薬学会第139年会千葉
- Data Source
  KAKENHI-PROJECT-18H02579
[Presentation] Activation of redox signaling pathways mediated by xenobiotic electrophiles.2019
- Author(s)
  Kumagai Yoshito
- Organizer
  The 10th International Conference on Nutrition and Physical Activity on Aging, Obesity and Cancer
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Activation of the Keap1/Nrf2 pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L.2019
- Author(s)
  Kumagai Yoshito
- Organizer
  IUTOX 15th International Congress of Toxicology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE: Two sides of the same coin in protection against electrophilic stress.2019
- Author(s)
  Kumagai Yoshito
- Organizer
  The Environmental Response V / 17th JBS Biofrontier Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Phase-zero reaction as a primary defense systeme against electrophilic stress in out of cell: Involvement of reactive persulfides.2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Warabi Eiji、Shinkai Yasuhiro、Abiko Yumi、Ishii Isao、Joseph Lin、Motohashi Hozumi、Yamamoto Masayuki、Jon M. Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 1,4-Naphthoquinone-mediated activation of PTEN/Akt/CREB signaling and cytotoxicity are negatively regulated by sodium tetrasulfide.2019
- Author(s)
  Hirose Reiko、Abiko Yumi、Shinkai Yasuhiro、Kumagai Yoshito
- Organizer
  The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Persulfide and polysulfide species in plants to detoxify methylmercury.2019
- Author(s)
  Abiko Yumi、Katayama Yusuke、Kumagai Yoshito
- Organizer
  IUTOX 15th International Congress of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Understanding Adaptive Response to Electrophilic Stress.2019
- Author(s)
  Kumagai Yoshito
- Organizer
  2019 KSOT/KEMS Toxicology Workshop & Spring International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 創薬研究から見出されたリジン長鎖アシル化修飾の新規機能と新たな創薬研究への展開2019
- Author(s)
  伊藤昭博
- Organizer
  BioJapan2019
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] 内因性脂質代謝物N-アシルドーパミンによるHIF-1α 活性化機構2019
- Author(s)
  石倉菜摘、前本佑樹、青木元秀、橘高敦史、上杉志成、吉田稔、伊藤昭博
- Organizer
  第24回化学生物学研究会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] A 3D structure modeling of metallothionein-3 and its related function as a sulfane sulfur binding protein．2019
- Author(s)
  Yunjie Ding、Shinkai Yasuhiro、Akiyama Masahiro、Kumagai Yoshito
- Organizer
  フォーラム2019：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Dietary arginine deficiency increases lipid content in the liver through a decrease in adenine nucleotide metabolites2019
- Author(s)
  Yamanaka Daisuke, Hiroki Nishi, Yuki Goda, Mikako Kumano, Haruka Nagata, Sakiko Taniguchi, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Conversion of SIRT2 catalytic activity from deacetylase to defatty-acylase by fatty-acyl substrates2019
- Author(s)
  Norio Kudo, Akihiro Ito, Mayumi Arata, Akiko Nakata, Seiji Matsuoka, Daria Monaldi, Manfred Jung, Minoru Yoshida
- Organizer
  FASEB Conference on The Reversible Protein Acetylation in Health and Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] S-Sulfuration of Cys215 is required for reversibility of PTP1B activity.2019
- Author(s)
  Kumagai Yoshito、Abiko Yumi、Nho Cong Luong
- Organizer
  The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Metallothionein-3 as a sulfur binding protein: Identification, characterization and 3D structure modeling.2019
- Author(s)
  Shinakai Yasuhiro、Yunjie Ding、Akiyama Masahiro、Jon M Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  The Environmental Response V / 17th JBS Biofrontier Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] The obligatory role of the S-sulfuration in reversibility of PTP1B activity.2019
- Author(s)
  Abiko Yumi、Nho C. Luong、Jon M. Fukuto、Funato Y、Miki H、Eva Doka、Markus Dagnell、Ida Tomoaki、Noemi Balog、Belen Espinosa、Nishimura A、Justin R. Prigge、Edward E. Schmidt、Elias S. J. Arner、Akaike Takaaki、 Peter Nagy、Kumagai Yoshito
- Organizer
  1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE act as critical molecules in parallel pathways for regulation of electrophilic stress in mice.2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Shinkai Yasuhiro、Ishii Isao、Ida Tomoaki、Akaike Takaaki、Yamamto Masayuki、Kumagai Yoshito
- Organizer
  The Environmental Response V / 17th JBS Biofrontier Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Regulation of electrophilic stress by reactive persulfide released in out of cell:Phase-zero reaction.2019
- Author(s)
  Akiyama Masahiro、Unoki Takamizu、Warabi Eiji、Shinkai Yasuhiro、Ishii Isao、Joseph Lin、Motohashi Hozumi、Yamamoto Masayuki、Jon M. Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Rbfox2 protein mediates exon 11 inclusion in insulin receptor alternative splicing in hepatoma cells2019
- Author(s)
  Naoyuki Kataoka, Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Role of sulfane sulfur in metallothionein-3 as a model zinc-binding protein.2019
- Author(s)
  Kumagai Yoshito
- Organizer
  1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Comprehensive screening for lysine long-chain fatty acyl proteins2019
- Author(s)
  Akihiro Ito, Ryu Kato, Kota Noritsugu, Takehiro Suzuki, Naoshi Dohmae, Minoru Yoshida
- Organizer
  FASEB Science Research Conference: Reversible Protein Acetylation in Health and Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] A paradigm shift to redox signal regulation by reactive sulfur species from metallothionein-32019
- Author(s)
  Kumagai Yoshito
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Dietary arginine deficiency increases lipid content in the liver through a decrease in adenine nucleotide metabolites2019
- Author(s)
  Yamanaka Daisuke, Hiroki Nishi, Yuki Goda, Mikako Kumano, Haruka Nagata, Sakiko Taniguchi, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Electrophilic stress: Good or Bad?2018
- Author(s)
  Kumagai Yoshito
- Organizer
  Environmental Health Conference 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] ユビキチン結合酵素UBE2D1のS-ニトロシル化修飾による機能変化2018
- Author(s)
  藤河香奈、伊藤昭博、上原孝
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Activation of redox signal transduction pathways mediated by electrophilic metals2018
- Author(s)
  Kumagai Yoshito
- Organizer
  10th Congress of Toxicology in Developing Countries
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Persulfide as a protection factor to block peroxidation of protein cysteine residue2018
- Author(s)
  Nho Cong Luong、Abiko Yumi、Kumagai Yoshito
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Function of novel S-nitrosylated proteins identified by biotin switch method with LC-MS/MS analysis2018
- Author(s)
  K.NAKAHARA, H.HIRAOKA, A.ITO, T.UEHARA
- Organizer
  Society for Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02579
[Presentation] Activation of Epidermal Growth Factor Receptor Signaling Through S-oxidation of Protein Tyrosine Phosphatase 1B in A431 Cells by Reactive Oxygen Species Produced from 9 10-Phenanthrenequinone2018
- Author(s)
  Luong Cong Nho、Abiko Yumi、Kumagai Yoshito
- Organizer
  The 8th International Congress of Asian Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Modulation of unfolded protein response by methylmercury2018
- Author(s)
  Hideki Hiraoka、Kengo Nakahara、Kosaku Okuda、Yoshito Kumagai、Takashi Uehara
- Organizer
  WCP2018 18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Electrophilic stress regulated by reactive sulfur species2018
- Author(s)
  Kumagai Yoshito
- Organizer
  The 10th International Conference on Home Oxygenase 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Function of novel S-nitrosylated proteins identified by biotin switch method with LC-MS/MS analysis2018
- Author(s)
  K.NAKAHARA、H.HIRAOKA、A.ITO、T.UEHARA
- Organizer
  Society for Neuroscience 2018（SfN 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] アルギニン不足は肝臓におけるアデニンヌクレオチド代謝経路化合物の減少を介して肝臓脂肪量を増加させる2018
- Author(s)
  山中大介, 西宏起, 合田祐貴, 熊野未佳子, 長田悠加, 谷口紗貴子, 伊藤公一, 伯野史彦, 高橋伸一郎
- Organizer
  第12回アミノ酸学会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アルギニン不足は肝臓におけるアデニンヌクレオチド代謝経路化合物の減少を介して肝臓脂肪量を増加させる2018
- Author(s)
  山中大介, 西宏起, 合田祐貴, 熊野未佳子, 長田悠加, 谷口紗貴子, 伊藤公一, 伯野史彦, 高橋伸一郎
- Organizer
  第12回アミノ酸学会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Electrophilic stress: Good or bad?2018
- Author(s)
  Kumagai Yoshito
- Organizer
  The 6th Conference of the Japanese Association for Hypoxia Biology International Symposium for Innovative Areas Oxygen Biology and New Insights into Ion Channel Functions and Pharmacology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Persulfides and Polysulfides as Phytochemicals to Detoxify MeHg2018
- Author(s)
  Abiko Yumi、Katayama Yusuke、Akiyama Masahiro、Kumagai Yoshito
- Organizer
  The 8th International Congress of Asian Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] ユビキチン結合酵素UBE2D1のS-ニトロシル化修飾による機能変化2018
- Author(s)
  藤河香奈、伊藤昭博、上原　孝
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H02579
[Presentation] A variety of adaptive responses to atmospheric electrophiles2018
- Author(s)
  Kumagai Yoshito
- Organizer
  Tsukuba Global Science Week 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Environmental electrophiles and reactive sulfur species: implications to regulation of redox signaling and toxicity2018
- Author(s)
  Kumagai Yoshito
- Organizer
  The 8th International Congress of Asian Society of Toxicology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Understanding unique adaptive response to electrophilic stress2018
- Author(s)
  Kumagai Yoshito
- Organizer
  BiomedicMedicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Molecular mechanism of Akt signaling evoked by 1,2-naphthoquinone2018
- Author(s)
  Kengo Nakahara、Hideki Hiraoka、Kyohei Hamada、Yoshito Kumagai、Takashi Uehara
- Organizer
  WCP2018 18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] リジン長鎖アシル化修飾による転写因子TEADの活性制御機構の解析2018
- Author(s)
  則次恒太、伊藤昭博、小川健司、鈴木健裕、堂前直、吉田稔
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-16K14674
[Presentation] 転写因子TEADのリジン長鎖アシル化修飾制御機構とその機能の解析2017
- Author(s)
  則次恒太、伊藤昭博、小川健司、鈴木健裕、堂前直、吉田稔
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K14674
[Presentation] Analysis of tissue-specific alternative splicing of insulin receptor pre-mRNA2017
- Author(s)
  Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin system in Physiology & Disease
- Place of Presentation
  Marriot Hotel Ventura (Ventura, CA, USA)
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Discovery of novel anti-diabetic drugs by interrupting the association between DGKζ and IRS-12017
- Author(s)
  Bu-Chin Yu, Akihiro Ito, Minoru Yoshida, Yasutoshi Ando, Tin-Yu Liu, Fumihiko Hukuno, Kazuhiro Chida , Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Dietary amino acids control lipid accumulation in the liver, skeletal muscle or adipose tissue in an amino acid-specific manner2017
- Author(s)
  Daisuke Yamanaka, Hiroki Nishi, Yuki Goda, 1Mikako Kumano, Koichi Ito, Masaya Katsumata, Hisanori Kato, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Long chain fatty acyl lysine modification of TEAD transcription factors2017
- Author(s)
  Akihiro Ito, Kota Noritsugu, Takehiro Suzuki, Naoshi Dohmae, Minoru Yoshida
- Organizer
  FASEB Science Research Conference「Reversible Acetylation on Health and Disease (HDACs)」
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14674
[Presentation] 新規リジン長鎖アシル化タンパク質TEADの機能解析2017
- Author(s)
  則次恒太、伊藤昭博、工藤紀雄、鈴木健裕、堂前直、吉田稔
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K14674
[Presentation] Analysis of tissue-specific alternative splicing of insulin receptor pre-mRNA2017
- Author(s)
  Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Novel functions of lipid metabolites as endogenous SIRT2 inhibitors2016
- Author(s)
  Akihiro Ito,, Norio Kudo, Akiko Nakata, Satoko Maeda, Minoru Yoshida
- Organizer
  The 8th Korea-Japan Chemical Biology Symposium
- Place of Presentation
  Pacific Hotel Okinawa, Naha, Okinawa
- Year and Date
  2016-01-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26650011
[Presentation] Molecular Mechanism of PI 3-Kinase-Akt Signaling Stimulated by 1,2-naphthoquinone(NQ)2016
- Author(s)
  Hideki Hiraoka,　Kyouhei Hamada, Kengo Nakahara, Yoshito Kumagai, Takashi Uehara
- Organizer
  23rd Annual Meeting of the Society for Redox Biology and Medicine
- Place of Presentation
  HYATT REGENCY San Francisco
- Year and Date
  2016-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04649
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA2016
- Author(s)
  Takashito Nakura, Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi.
- Organizer
  RNA2016
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA.2016
- Author(s)
  Takashito Nakura, Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi.
- Organizer
  RNA2016
- Place of Presentation
  国立京都国際会館（京都府、京都）
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Regulation of histone deacetylase 6(HDAC6) activity via S-nitrosylation2016
- Author(s)
  Kosaku Okuda, Akihiro Ito, Takashi Uehara
- Organizer
  第16回日本ＮＯ学会学術集会・第9回国際ＮＯ学会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04649
[Presentation] Regulation of Histone Deacetylase 6(HDAC6)Activity via S-nitrosylation2016
- Author(s)
  Kosaku Okuda, Akihiro Ito, Takashi Uehara
- Organizer
  23rd Annual Meeting of the Society for Redox Biology and Medicine
- Place of Presentation
  HYATT REGENCY San Francisco
- Year and Date
  2016-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04649
[Presentation] Diacylglycerol kinase zeta and PIP5K1 cooperatively enhanced insulin-induced glucose uptake in 3T3-L1 adipocytes2015
- Author(s)
  Fumihiko Hakuno, Ting-Yu Liu T, M Kakino, Hitoshi Fujimoto, Yasutoshi Ando, Kazuhiro Chida, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The protein or compound that inhibits interaction between DGKζ and IRS-1 restore the TNF-α-induced suppression of glucose uptake in 3T3-L1 adipocytes.2015
- Author(s)
  Yu BC, Liu TY, Ando Y, Ito A, Yoshida M, Hakuno F , Chida K, Takahashi S-I
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA2015
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Metabolic diseases, metabolic syndrome, metabolomics, and aging2015
- Author(s)
  BuChin Yu, TingYu Liu, Yasutoshi Ando, Akihiro Ito, Minoru Yoshida, Fumihiko Hakuno, Kazuhiro Chida and Shin-Ichiro Takahashi
- Organizer
  BMB2015（第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The deubiquitinating enzyme, USP9X positively regulates IGF-I-dependent cell growth by inhibition of degradation of insulin receptor substrate (IRS)-2 in cancer cells2015
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] NAD依存性脱アセチル化酵素SIRT2による細胞運動制御機構とその内因性阻害物質2015
- Author(s)
  伊藤昭博、吉田　稔
- Organizer
  第2回北陸エピジェネティクス研究会
- Place of Presentation
  富山大学、富山市、富山県
- Year and Date
  2015-11-11
- Invited
- Data Source
  KAKENHI-PROJECT-26650011
[Presentation] NAD依存的脱アセチル化酵素SIRT2による細胞運動制御機構2015
- Author(s)
  伊藤昭博、前田里子、吉田稔
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-26650011
[Presentation] タンパク質SUMO化を標的とした阻害剤の探索―タンパク質SUMO化酵素阻害剤およびSUMO-SIM結合阻害剤について―2014
- Author(s)
  伊藤昭博
- Organizer
  第11回SUMO研究会
- Place of Presentation
  和光
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), emerging as a novel regulator of alternative pre-mRNA splicing2014
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Mechanisms for Regulation of Acetylation of Insulin-Receptor Substrate (IRS)-1, Regulating Insulin-Like Growth Factor (IGF) Signaling2014
- Author(s)
  Kumiko Fujieda, Yosuke Yoneyama, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  ICE/ENDO 2014
- Place of Presentation
  McComick Place West, Chicago Illinois, USA
- Year and Date
  2014-06-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] タンパク質SUMO化を標的とした化合物の同定とその抗がん活性2014
- Author(s)
  伊藤昭博
- Organizer
  新学術領域研究　天然物ケミカルバイオロジー地区ミニシンポジウム　「化学と生物学の壁と打開策：次世代天然物ケミカルバイオロジー研究の開拓へ」
- Place of Presentation
  和光
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] SIRT2 regulates cell migration through Keap1-mediated cell periphery localization of cortactin2014
- Author(s)
  Akihiro Ito, Satoko Maeda, Minoru Yoshida
- Organizer
  Max Planck Joint Research Center for Systems Chemical Biology 3rd Annual Symposium
- Place of Presentation
  Schloss Ringberg, Kreuth, Germany
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-26650011
[Presentation] Novel Mechanisms by which Nedd4-IRS-2 complexes enhance IGF-I signals, and their roles in IGF-I action in prostate cancer cell proliferation2014
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Yasushi Saeki, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The deubiquitinating enzyme, USP9X positively regulates insulin-like growth factor (IGF)-dependent cell growth by inhibition of degradation of IGF-I receptor (IGF-IR) and insulin receptor substrate (IRS)-2 in cancer cells2014
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Akihiro Ito, Claire Worrall, Leonard Girnita, Keiji Tanaka, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] タンパク質 SUMO化を標的とした化合物の同定とその抗がん活性2014
- Author(s)
  伊藤昭博
- Organizer
  新学術領域天然物ケミカルバイオロジー地区ミニシンポジウム「化学と生物学の打開策次世代天然物ケミカルバイオロジー研究の開拓へ」
- Place of Presentation
  和光
- Year and Date
  2014-03-01
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] タンパク質 SUMO化を標的とした阻害剤の探索 -タンパク質SUMO化酵素阻害剤および SUMO-SIM結合阻害剤について -2014
- Author(s)
  伊藤昭博
- Organizer
  第11回SUMO研究会
- Place of Presentation
  和光
- Year and Date
  2014-01-10
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] インスリン受容体RNAの選択的スプライシングの新しい制御機構2014
- Author(s)
  成田佑果、尾添淳文、福嶋俊明、片岡直行、伊藤昭博、吉田稔、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 脱SUMO化酵素SENP1阻害剤の探索2013
- Author(s)
  伊藤昭博、掛谷秀昭、吉田稔
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2013-06-13
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] 脱SUMO化酵素SENP1を標的とした阻害剤の探索2013
- Author(s)
  竹本操、伊藤昭博、広浜美香子、掛谷秀昭、吉田稔
- Organizer
  日本ケミカルバイオロジー学会　第8回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback loop in insulin/IGF signaling2013
- Author(s)
  Hidehito Yoshihara, Toshikai Fukushima, Furuta Haruka, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Shunichiro Iemura, Tohru Natsume, Shin-Ichiro Takahashi
- Organizer
  EMBO Conference"Ubiquitin and ubiquitin-like proteins : from structure to function
- Place of Presentation
  Riva del Garda, Italy
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] インスリン受容体基質（IRS）-1のアセチル化酵素と脱アセチル化酵素の特定2013
- Author(s)
  藤枝久美子、米山鷹介、伊藤明博、吉田稔、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Identification of proteins proximal to insulin receptor substrate (IRS)-1 in the intracellular vesicle compartment2013
- Author(s)
  Yosuke Yoneyama, Akihiro Ito, Kazuhiro Chida, Minoru Yoshida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: Insulin-like growth factors in physiology and diseases
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] タンパク質SUMO化を標的とした化合物の探索2013
- Author(s)
  伊藤昭博、吉田稔
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] インスリン受容体基質（IRS）-1のアセチル化酵素と脱アセチル化酵素の特定2013
- Author(s)
  藤枝久美子、米山鷹介、伊藤明博、吉田稔、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Year and Date
  2013-06-22
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Phosphoglycerate-mutase 5 (PGAM5) is involved in dephosphorylation of insulin receptor substrates (IRSs) and controlling insulin-like activities2013
- Author(s)
  Junichi Inobe, Toshiaki Fukushima, Akihiro Ito, Yukako Kida, Takashi Shiano, Kazuhiro Chida, Minoru Yoshida, Tomoichiro Asano, Kouske Takeda, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: Insulin-like growth factors in physiology and diseases
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback loop in insulin/IGF signaling2013
- Author(s)
  Hidehito Yoshihara, Toshikai Fukushima, Furuta Haruka, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Shunichiro Iemura, Tohru Natsume, Takahashi Shin-Ichiro
- Organizer
  EMBO Conference “Ubiquitin and ubiquitin-like proteins: from structure to function
- Place of Presentation
  Riva del Garda, Italy
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Discovery of Spectomycin B1 as a SUMO E2 Inhibitor2012
- Author(s)
  Akihiro Ito, Mikako Hirohama, Yasuhiro Igarashi, Yasumitsu Kondoh, Tamio Saito, hiroyuki Osada, Minoru Yoshida
- Organizer
  The 6th Korean-JapanChemical Biology Symposium
- Place of Presentation
  札幌
- Year and Date
  2012-01-27
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] Spectomycin B1 suppresses Estrogen Receptor α-Dependent Breast Cancer Cell Growth by inhibiting a SUMO E2 Activity2012
- Author(s)
  Akihiro Ito, Mikako Hirohama, Yasuhiro Igarashi, Yasumitsu Kondoh, Tamio Saito, Hiroyuki Osada, Minoru Yoshida
- Organizer
  2nd SNU-RIKEN Joint Symposium on Chemical Biology
- Place of Presentation
  Chuncheon, South Korea
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] Ubiquitin ligase Nedd4 interacts with insulin receptor substrate (IRS)-2 in response to humoral/nutritional stimuli, thereby enhancing IRS-2-mediated IGF/insulin signals through a novel mechanism2012
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Hideyuki Sakoda, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Discovery of spectomycin B1 as a SUMO E2 inhibitor and its potential for anti-breast cancer therapy2012
- Author(s)
  Akihiro Ito, Mikako Hirohama, Yasuhiro Igarashi, Yasumitsu Kondoh, Tamio Saito, Hiroyuki Osada, Minoru Yoshida
- Organizer
  Riken-Max Planck Joint Research Center kick off symposium
- Place of Presentation
  Dortmund, Germany
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] SUMO E2阻害剤としてのエラグ酸の発見とがん治療薬としての可能性2012
- Author(s)
  伊藤昭博、木村賢一、吉田稔
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] エラグ酸によるタンパク質SUMO化阻害2012
- Author(s)
  米山操、広浜美香子、木村賢一、半田宏、伊藤昭博、吉田稔
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] Spectomycin B1 suppresses Estrogen Receptor α-Dependent Breast Cancer Cell Growth by inhibiting a SUMO E2 Activity2012
- Author(s)
  Akihiro Ito, Mikako Hirohama, Yasuhiro Igarashi, Yasumitsu Kondoh, Tamio Saito, Hiroyuki Osada, Minoru Yoshida
- Organizer
  2nd SNU-RIKEN Joint Symposium on Chemical Biology, Chuncheon
- Place of Presentation
  Chuncheon, South Korea
- Year and Date
  2012-05-18
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] Discovery of Spectomycin B1 as a SUMO E2 Inhibitor2012
- Author(s)
  Akihiro Ito, Mikako Hirohama, Yasuhiro Igarashi, Yasumitsu Kondoh, Tamio Saito, hiroyuki Osada, Minoru Yoshida
- Organizer
  The 6th Korean-Japan Chemical Biology Symposium
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] SUMO化・脱SUMO化阻害剤の現状2012
- Author(s)
  伊藤昭博
- Organizer
  第10回SUMO化研究会
- Place of Presentation
  熊本
- Year and Date
  2012-11-22
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] Discovery of spectomycin B1 as a SUMO E2 inhibitor and its potential for anti-breast cancer therapy2012
- Author(s)
  Akihiro Ito, Mikako Hirohama, Yasuhiro Igarashi, Yasumitsu Kondoh, Tamio Saito, Hiroyuki Osada, Minoru Yoshida
- Organizer
  Riken-Max Planck Joint Research Centerkick off symposium
- Place of Presentation
  Dortmund, Germany
- Year and Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] SUMO E2阻害剤の発見2011
- Author(s)
  伊藤昭博
- Organizer
  第2回京都大学GCOE-理化学研究所共同シンポジウム
- Place of Presentation
  京都
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate (IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals followed by mitogenic bioactivity of insulin-like growth factors (IGFs)2011
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Kazuhiro Chida, Tomoichiro Asano, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference"Insulin-like Growth Factors in Physiology & Disease"
- Place of Presentation
  Ventura CA, USA
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Spectomycin B1はSUMO E2を標的とする新規SUMO化阻害剤である2011
- Author(s)
  伊藤昭博、吉田稔
- Organizer
  日本がん分子標的治療学会第15回学術集会
- Place of Presentation
  東京
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] タンパク質SUMO化を標的とした小分子化合物の探索2011
- Author(s)
  伊藤昭博
- Organizer
  第9回SUMO研究会
- Place of Presentation
  出雲
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] 肝細胞においてNedd4はインスリン受容体基質(IRS)-2のユビキチン化を介してインスリンシグナルを増強する2011
- Author(s)
  福嶋俊明,吉原英人,伯野史彦,佐伯泰,田中啓二,伊藤昭博,中津祐介,鎌田英明,高橋伸一郎,浅野知一郎
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(口頭発表、ポスター発表)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Spectomycin B1はSUMO E2を標的とする新規SUMO化阻害剤である2011
- Author(s)
  伊藤昭博、吉田稔
- Organizer
  日本がん分子標的治療学会　第15回学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23510288
[Presentation] ミトコンドリアにおける脱アセチル化酵素SIRT3による新規エネルギー代謝制御2010
- Author(s)
  伊藤昭博
- Organizer
  日本農芸化学会2010大会
- Place of Presentation
  東京
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21651086
[Presentation] Regulation of energy metabolism by SIRT32010
- Author(s)
  伊藤昭博
- Organizer
  The 5th Japan-Korea Chemical Biology Symposium
- Place of Presentation
  釜山
- Year and Date
  2010-01-27
- Data Source
  KAKENHI-PROJECT-21651086
[Presentation] SIRT3 regulates ketogenesis2009
- Author(s)
  伊藤昭博
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Lucca
- Year and Date
  2009-08-10
- Data Source
  KAKENHI-PROJECT-21651086
[Presentation] エネルギー代謝を制御する脱アセチル化酵素SIRT32009
- Author(s)
  伊藤昭博
- Organizer
  第20回新薬創製談話会
- Place of Presentation
  熱海
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21651086
[Presentation] 脱アセチル化酵素SIRT3によるケトン体生成制御2009
- Author(s)
  伊藤昭博
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21651086
[Presentation] IRS結合タンパク質、DGKζを介した新しい糖取り込みの調節機構
- Author(s)
  劉亭妤、柿野衛、冨士本仁、伊藤昭博、吉田稔、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン受容体RNAの選択的スプライシングの新しい制御機構
- Author(s)
  成田佑果、尾添淳文、福嶋俊明、片岡直行、伊藤昭博、吉田稔、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] A deubiquitinating enzyme, USP7, is associated with IRS-2 forming a negative feedback loop in IGF signaling
- Author(s)
  Hidehito Yoshihara, Fumihko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Nedd4-IRS2複合体の形成機構と複合体ががん細胞の過増殖誘導に果たす役割
- Author(s)
  福嶋俊明、吉原英人、古田遥佳、伯野史彦、千田和広、佐伯泰、田中啓二、伊藤昭博、吉田稔、中津佑介、鎌田英明、高橋伸一郎、浅野知一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Molecular mechanisms by which ubiquitin ligase Nedd4 enhances IRS-2-mediated IGF signaling
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Yasushi Saeki, Yusuke Nakatsu, Hideaki Kamata, Shin-Ichiro Takahashi, Tomoichiro Asano
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  神戸ポートアイランド, 神戸
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] The deubiquitinating enzyme, USP9X positively regulates insulin-like growth factor (IGF)-dependent cell growth by inhibition of degradation of IGF-I receptor (IGF-IR) and insulin receptor substrate (IRS)-2 in cancer cells
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Akihiro Ito, Claire Worrall, Leonard Girnita, Keiji Tanaka, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The International Congress of the GRS and the IGF Society
- Place of Presentation
  Suntec Convention & Exhibition Centre, Suntec City, Singapore
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] The deubiquitinating enzyme, USP9X positively regulates IGF-I-dependent cell growth by inhibition of degradation of insulin receptor substrate (IRS)-2 in cancer cells
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF and Insulin System in Physiology and disease
- Place of Presentation
  Ventura Beach Marriott, Ventura, USA
- Year and Date
  2015-03-08 – 2015-03-13
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback loop in insulin/IGF signaling
- Author(s)
  Hidehito Yoshihara, Toshiaki Fukushima, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Shunichiro Iemura, Tohru Natsume, Tomoichiro Asano, Kazuhiro Chida, Leonard Girnita, and Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] がん細胞では、脱ユビキチン化酵素USP9XによりIGF-I受容体およびIRS-2の分解が抑制され、IGF依存性増殖が亢進している
- Author(s)
  古田遥佳、吉原英人、福嶋俊明、佐伯泰、田中啓二、伊藤昭博、吉田稔、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Novel Mechanisms by which Nedd4-IRS-2 Complexes Enhance IGF-I signals, and their Roles in IGF-I Action in Prostate Cancer Cell Proliferation
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Yasushi Saeki, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Organizer
  The International Congress of the GRS and the IGF Society
- Place of Presentation
  Suntec Convention & Exhibition Centre, Suntec City, Singapore
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback llop in insulin/IGF signaling
- Author(s)
  Hidehito Yoshihara, Toshikai Fukushima, Furuta Haruka, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Shunichiro Iemura, Tohru Natsume, Takahashi Shin-Ichiro
- Organizer
  EMBO Conference
- Place of Presentation
  Riva del Garda, Italy
- Year and Date
  2013-10-01 – 2013-10-05
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), emerging as a novel regulator of alternative pre-mRNA splicing
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA.
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08 – 2015-03-13
- Data Source
  KAKENHI-PROJECT-25660210

1. TAKAHASHI Shin-Ichiro (00197146)

# of Collaborated Projects: 8 results

# of Collaborated Products: 45 results
2. HAKUNO Fumihiko (30282700)

# of Collaborated Projects: 8 results

# of Collaborated Products: 43 results
3. YASUSHI Saeki (80462779)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
4. Yoshida Minoru (80191617)

# of Collaborated Projects: 4 results

# of Collaborated Products: 54 results
5. NISHIHARA Masugi (90145673)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KATAOKA Naoyuki (60346062)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
7. Dohmae Naoshi (00321787)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
8. Uehara Takashi (00261321)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
9. Fukushima Toshiaki (70543552)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
10. FUJII WATARU (40708161)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. Kamei Hiroyasu (00610362)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. Kumagai Yoshito (00250100)

# of Collaborated Projects: 2 results

# of Collaborated Products: 57 results
13. 佐々木和樹 (10415169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 梅原崇史 (20415095)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 西村慎一 (30415260)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
16. どど孝介 (20415243)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
17. 新開泰弘 (10454240)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
18. HIRAI Go (50359551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KANEKO Gen (30466809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Moto Kenichi (90333335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. Kudo Norio (80632421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. SHIOYA Ryuji (70282689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. Tamio Mizukami (80367896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. SASAKI Ryuzo (60077378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. HASEGAWA Makoto (10367899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. NAGAI Nobuo (90260281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. Wada Shuichi (20378607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. SUZUKI Takayoshi (90372838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
29. MIYATA Naoki (50114674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 永坂岳司 (30452569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 竹内靖雄 (00163387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 西田基宏 (90342641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
33. 秋山雅博 (60754570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
34. 菊地正樹 (20742430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 白井智量 (00639586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
36. 鹿島誠 (10780562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 小林功 (30774757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 加藤百合 (10732042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. Chida Kazuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
40. Yamanaka Daisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
41. Asano Tomoichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
42. Takenaka Asako

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
43. OZOE Atsufumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
44. Higashi Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. Girnita Leonard

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
46. Torres-Aleman Ignacio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. Duan Cunming

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. Weghuber Julian

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. Belfiore Antonino

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. O'Connor Rosemary

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. Forbes Briony

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. AMO Taku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. SUZUKI Takafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
54. YAHAGI TADAHIRO

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. TAKASUGI Nobumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. IDE Soichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 鵜木隆光

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
59. 駒田雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
60. 井田智章

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
61. 金倫基

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
62. 五月女宜裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
63. 西村明幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
64. 鎌田英明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
65. 井上英史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
66. 安孫子ユミ

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
67. ChhipiShrestha Jagat

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
68. 黒瀬等

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
69. 立石大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
70. 鈴木裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
71. 鍛冶利幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
72. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
73. 宮本圭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
74. 長田裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
75. 半田宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
76. 高野義孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
77. 池上貴久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
78. ZHANG Kam

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
79. VOET Arnout

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
80. 近藤恭光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
81. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
82. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
83. 西山和宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ito Akihiro 伊藤 昭博

ITO Akihiro 伊藤 昭博

伊藤 昭博 イトウ アキヒロ

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Elucidation of novel regulation of lipid metabolism by lysine lipid modifications and its controlPrincipal Investigator

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Elucidation of cell regulatory mechanism by lysine long-chain fatty modificationsPrincipal Investigator

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Identification and functional analyses of lysine long chain fatty acylated proteinsPrincipal Investigator

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Ito Akihiro 伊藤昭博

ITO Akihiro 伊藤昭博

伊藤昭博イトウアキヒロ