MATSUSHITA SHUZO 松下修三

… Alternative Names

MATSUSHITA Shuzo 松下修三

松下修三マツシタシユウゾウ

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Researcher Number	00199788
Other IDs
Affiliation (Current)	2025: 熊本大学, ヒトレトロウイルス学共同研究センター, 特任教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 熊本大学, ヒトレトロウイルス学共同研究センター, 特任教授 2019 – 2020: 熊本大学, ヒトレトロウイルス学共同研究センター, 教授 2006 – 2018: 熊本大学, エイズ学研究センター, 教授 1997 – 2003: 熊本大学, エイズ学研究センター, 教授 1995 – 1997: 熊本大学, 医学部, 助手 … More 1996: 熊本大学, 医学部附属病院, 助手 1995 – 1996: 熊本大学, 医学部・附属病院, 助手 1993: 熊本大学, 医学部・附属病院, 助手 1992: 熊本大学医学部, 附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Infectious disease medicine / Basic Section 54030:Infectious disease medicine-related / 内科学一般 / Hematology / Biological Sciences / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Basic Section 10030:Clinical psychology-related / Biological Sciences / Laboratory animal science / Virology / Hematology
Keywords	Principal Investigator 中和抗体 / ウイルス / 内科 / 感染症 / HIV-1 / 抗イディオタイプ抗体 / HIV / 免疫学 / ATL / neutralizing antibody … More / 感染症防御学 / SARS-CoV-2 / 新型コロナウイルス感染症（COVID-19） / エイズワクチン開発 / イディオタイプワクチン / AIDS / 感染症治療学 / phage library / mimotope / HIV vaccine / ファージライブラリー / HIVワクチン / ミモトープ / chemokine receptor / anti-anti-idiotype / ケモカインレセプター / Reverse transcriptase inhibitor / Neutralizing antibody / Vpr transgenic mouse / Membrane fusion inhibitor / CXCR4 inhibitor / Drug resistance / CCR5 inhibitor / Protease inhibitor / u-CRM1 / rev / フィットネス / 転写制御 / tat / CTL / 抗ウイルス剤 / 発症予防ワクチン / ケモカインレセプター阻害剤 / hu-PBL-SCIDマウス / 遺伝子発現制御 / トランスジェニックマウス / CXCR4拮抗剤 / T140 / 逆転写酵素阻害剤 / Vprトランスジェニックマウス / 膜融合阻害剤 / CXCR4阻害剤 / 薬剤耐性 / CCR5阻害剤 / プロテアーゼ阻害剤 / ganciclovir / Thymidine kinase / HIV vector / gene therapy / 成人T細胞白血病 / ガンシクロビル / チミジンキナーゼ / HIVベクター / 遺伝子治療 / 動物モデル / 感染防御学 / ADCC / 交差中和抗体 / エンベロープ蛋白 / AIDSワクチン / ワクチン開発 / 再活性化 / 潜伏感染 / HTLV-I … More Except Principal Investigator HIV-1 / HIV / ケモカイン / エイズ / 宿主因子 / HIV複製 / スクリーニング / 行動エラー / IADL / 認知機能 / IADL検査 / 認知機能検査 / HAND / ケモカイン受容体 / ワクチン / 抗HIV剤 / Bystander effect / N-Myristoylation / コレセプター / VR / HIV関連認知機能障害(HAND) / マイクロエラー / データ収集 / 神経心理学 / アカゲザル / 中和抗体 / vaccine / SIV / antibody / Chemokine Receptor / Chemokine / AIDS Control / Immune response / Pathophysiology / Host Factors / 薬剤耐性 / 抗HIV免疫 / 制御 / 免疫 / 病態 / antiviral drugs / animal model / anti HIV response / Human genome / host factors / Viral genome / AIDS pathogenesis / HIV replication / 免疫応答 / ウイルス病原性 / 複製制御 / SCIDマウス / hPBL / Th2 / Th1 / 多型性 / 細胞侵入 / 化学療法 / 抗ウイルス剤 / 動物モデル / 抗HIV応答 / ヒトゲノム / ウイルスゲノム / AIDS病態 / リンパ球ターンオーバー / 経口投与 / マカクサルモデル / HAART / SHIV / CTL / V3loop / エイズ遺伝子治療 / 硫酸アルキルオリゴ糖 / 中和モノクローナル抗体 / クワシスピーシス / Rev / リボザイム / V3 loop / Tat / 遺伝子治療 / アンチセンス / 阻害剤 / 受容体 / レチノイド / グルココルチコイド / ATL Less

Induction of SARS CoV-2 neutralizing antibodies by anti-idiotype antibodiesPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Shuzo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
HIV関連神経認知障害(HAND)診断ツールの標準値構築と動作エラーモデルの開発
- Principal Investigator
  
  坂本麻衣子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 10030:Clinical psychology-related
- Research Institution
  Saga University
Development of screening measures for detection of HIV-associated neurocognitive disorders (HAND)
- Principal Investigator
  
  Sakamoto Maiko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 10030:Clinical psychology-related
- Research Institution
  Saga University
Induction of HIV neutralizing antibodies by anti-idiotype antibodiesPrincipal Investigator
- Principal Investigator
  
  Matsushita Shuzo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
Research toward elimination of HIV persistent infected cells remaining under antiretroviral therapy (ART)Principal Investigator
- Principal Investigator
  
  Matsushita Shuzo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Development of antibody-inducing vaccine models by analysis of B404 which neutralizes various SIV strains
- Principal Investigator
  
  Kuwata Takeo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kumamoto University
Development of a panel of neutralizing monoclonal antibodies aiming toward HIV curePrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Shuzo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Development of vaccine against HIV/AIDS using a panel of neutralizing monoclonal antibodies.Principal Investigator
- Principal Investigator
  
  MATSUSHITA Shuzo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Development of vaccine that induces neutralizing antibodies to HIV-1Principal Investigator
- Principal Investigator
  
  MATSUSHITA Shuzo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kumamoto University
Basic Research for AIDS control
- Principal Investigator
  
  UCHIYAMA Takashi
- Project Period (FY)
  2002
- Research Category
  
  特定領域研究
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
サルを用いたHAARTと免疫療法の前臨床動物モデルの確立
- Principal Investigator
  
  吉村和久
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Development of mimotope vaccine against HIV-1Principal Investigator
- Principal Investigator
  
  MATSUSHITA Shuzo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kumamoto University
Basic Research for AIDS control A03 ; Prevention and control of AIDSPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Shuzo
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  KUMAMOTO UNIVERSITY
Analysis of the interaction between chemokine receptor and V3 region of HIV-gp120 by neutralizing antibodiesPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Shuzo
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kumamoto University
エイズの病態と制御に関する基礎研究柱5.感染と病態の制御
- Principal Investigator
  
  YAMAMOTO Naoki
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
生体のN-ミリストイル化反応阻害を介するエイズウイルス形成制御
- Principal Investigator
  
  庄司省三
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
エイズの基礎研究の動向調査と将来展望
- Principal Investigator
  
  UCHIYAMA Takashi
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kyoto University
HIV潜伏感染細胞の抗ミリストイル化剤による感染性ウイルス産生能消失機構
- Principal Investigator
  
  庄司省三
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Pathogenesis and Control of AIDS
- Principal Investigator
  
  NAGAI Yoshiyuki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Gene therapy for adult T-cell leukemia using HIV vectorPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Shuzo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
成人T細胞白血病ウイルスの潜伏感染と再活性化の機構Principal Investigator
- Principal Investigator
  
  松下修三
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
ATL細胞のグルココルチコイドおよびレチノイン酸受容体の解析
- Principal Investigator
  
  服部俊夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University

[Journal Article] Differential Ability of Spike Protein of SARS-CoV-2 Variants to Downregulate ACE22024
- Author(s)
  Maeda Yosuke、Toyoda Mako、Kuwata Takeo、Terasawa Hiromi、Tokugawa Umiru、Monde Kazuaki、Sawa Tomohiro、Ueno Takamasa、Matsushita Shuzo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 2 Pages: 1353-1353
- DOI
  10.3390/ijms25021353
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08602, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24378
[Journal Article] Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay2023
- Author(s)
  Toyoda Mako、Tan Toong Seng、Motozono Chihiro、Barabona Godfrey、Yonekawa Akiko、Shimono Nobuyuki、Minami Rumi、Nagasaki Yoji、Miyashita Yusuke、Oshiumi Hiroyuki、Nakamura Kimitoshi、Matsushita Shuzo、Kuwata Takeo、Ueno Takamasa
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 4 Pages: 00660-23
- DOI
  10.1128/spectrum.00660-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ1775, KAKENHI-PROJECT-22KK0277, KAKENHI-PROJECT-22K07089, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24139, KAKENHI-PROJECT-23K24378, KAKENHI-PROJECT-23K27640
[Journal Article] Comparison of neutralization activity against Omicron BA.2/BA.5 in sera from HCWs receiving heterologous/homologous COVID-19 vaccines.2023
- Author(s)
  Amano M, Ichikawa Y, Uemura Y, Matsumoto S, Maeda K,, Matsushita S, Shimada S, Mitsuya H.
- Journal Title
  
  Journal of Infection 2023 in press.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02970
[Journal Article] Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates2023
- Author(s)
  Matsumoto Kaho、Kuwata Takeo、Tolbert William D.、Richard Jonathan、Ding Shilei、Prevost Jeremie、Takahama Shokichi、Judicate George P.、Ueno Takamasa、Nakata Hirotomo、Kobayakawa Takuya、Tsuji Kohei、Tamamura Hirokazu、Smith Amos B.、Pazgier Marzena、Finzi Andres、Matsushita Shuzo
- Journal Title
  
  Journal of Virology
  
  Volume: 97 Issue: 1
- DOI
  10.1128/jvi.01638-22
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-21K19657
[Journal Article] Comparison of neutralization activity against Omicron BA.2/BA.5 in sera from HCWs receiving heterologous/homologous COVID-19 vaccines.2023
- Author(s)
  Amano M, Ichikawa Y, Uemura Y, Matsumoto S, Maeda K, Matsushita S, Shimada S, Mitsuya H.
- Journal Title
  
  J Infect
  
  Volume: 86 Issue: 5 Pages: e130-e132
- DOI
  10.1016/j.jinf.2023.01.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24379
[Journal Article] Longitudinal analysis of neutralization in sera from HCWs receiving 2 doses of Omicron BA.4/5-adapted bivalent vaccine.2023
- Author(s)
  Amano M, Ichikawa Y, Matsumoto S, Matsushita S, Shimada S, Mitsuya H.
- Journal Title
  
  J Infect
  
  Volume: 87 Issue: 5 Pages: e79-e82
- DOI
  10.1016/j.jinf.2023.08.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24379
[Journal Article] Neutralization against Omicron sublineages (BA.2/BA.5/BQ.1.1/XBB/XBB.1.5) in bivalent BNT162b2-vaccinated HCWs with or without risk factors, or following BT infection with Omicron.2023
- Author(s)
  Amano M, Otsu S, Uemura Y, Ichikawa Y, Matsumoto S, Higashi-Kuwata N, Matsushita S, Shimada S, Mitsuya H.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 17404-17404
- DOI
  10.1038/s41598-023-44484-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24379
[Journal Article] Restoration of Neutralization Activity Against Omicron BA.2 and BA.5 in Older Adults and Individuals With Risk Factors Following the Fourth Dose of Severe Acute Respiratory Syndrome Coronavirus 2 BNT162b2 Vaccine.2023
- Author(s)
  Amano M, Otsu S, Ichikawa Y, Higashi-Kuwata N, Matsushita S, Shimada S, Mitsuya H.
- Journal Title
  
  J Infect Dis.
  
  Volume: 227 Issue: 1 Pages: 161-163
- DOI
  10.1093/infdis/jiac393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24379
[Journal Article] Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C2023
- Author(s)
  Matsuura Kanako、Yamaura Mizuki、Sakawaki Hiromi、Himeno Ai、Pisil Yalcin、Kobayakawa Takuya、Tsuji Kohei、Tamamura Hirokazu、Matsushita Shuzo、Miura Tomoyuki
- Journal Title
  
  Virology
  
  Volume: 578 Pages: 171-179
- DOI
  10.1016/j.virol.2022.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970
[Journal Article] Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors2022
- Author(s)
  Wang Rongyi、Tsuji Kohei、Kobayakawa Takuya、Liu Yishan、Yoshimura Kazuhisa、Matsushita Shuzo、Harada Shigeyoshi、Tamamura Hirokazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 76 Pages: 117083-117083
- DOI
  10.1016/j.bmc.2022.117083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970
[Journal Article] Development and characterization of a panel of anti-idiotype antibodies to 1C10 that cross-neutralize HIV-1 subtype B viruses2022
- Author(s)
  Kaku Yu、Matsumoto Kaho、Kuwata Takeo、Zahid Hasan Md、Biswas Shashwata、Gorny Miroslaw K.、Matsushita Shuzo
- Journal Title
  
  Frontiers in Virology
  
  Volume: 2 Pages: 932187-932187
- DOI
  10.3389/fviro.2022.932187
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21H02970
[Journal Article] Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors2022
- Author(s)
  Tsuji Kohei、Kobayakawa Takuya、Konno Kiju、Masuda Ami、Takahashi Kohei、Ohashi Nami、Yoshimura Kazuhisa、Kuwata Takeo、Matsushita Shuzo、Harada Shigeyoshi、Tamamura Hirokazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 56 Pages: 116616-116616
- DOI
  10.1016/j.bmc.2022.116616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-20H03362
[Journal Article] Functional analysis of a monoclonal antibody reactive against the C1C2 of Env obtained from a patient infected with HIV-1 CRF02_AG2021
- Author(s)
  Md Zahid H, Kuwata T, Takahama S, Kaku Y, Biswas S, Matsumoto K, Tamamura H, Matsushita S
- Journal Title
  
  Retrovirology
  
  Volume: 18 Issue: 1 Pages: 23-23
- DOI
  10.1186/s12977-021-00568-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02970
[Journal Article] Clonality of HIV-1 and HTLV-1 infected cells in naturally coinfected individuals2021
- Author(s)
  Katsuya H, Cook L, Rowan AG, Melamed A, Turpin J, Ito J, Islam S, Miyazato P, Tan B, Matsuo M, Miyakawa T, Nakata H, Matsushita S, Taylor GP, Bangham CRM, Kimura S, Satou Y.
- Journal Title
  
  The Journal of Infectious Diseases
  
  Volume: 0 Issue: 2 Pages: 0-0
- DOI
  10.1093/infdis/jiab202
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03724, KAKENHI-PROJECT-18KK0230, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-19J01713, KAKENHI-PROJECT-20K15767
[Journal Article] A widely distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro2021
- Author(s)
  Matsuda K, Islam S, Takada T,Tsuchiya K, Tan BJY, Hattori S, Katsuya H, Kitagawa K, Kim KS, Matsuo M, Sugata K, Delino NS, Gatanaga H, Yoshimura K, Matsushita S, Mitsuya H, Iwami S, Satou Y, Maeda K
- Journal Title
  
  Cell Reports Methods
  
  Volume: 1 Issue: 8 Pages: 100122-100122
- DOI
  10.1016/j.crmeth.2021.100122
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-20K17480
[Journal Article] A Potent Anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germ Line Immunoglobulin Gene Polymorphism in Rhesus Macaques2021
- Author(s)
  Matsuoka Saori、Kuwata Takeo、Ishii Hiroshi、Sekizuka Tsuyoshi、Kuroda Makoto、Sano Masato、Okazaki Midori、Yamamoto Hiroyuki、Shimizu Mikiko、Matsushita Shuzo、Seki Yohei、Saito Akatsuki、Sakawaki Hiromi、Hirsch Vanessa M.、Miura Tomoyuki、Akari Hirofumi、Matano Tetsuro
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 7
- DOI
  10.1128/jvi.02455-20
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02666, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-18K07157, KAKENHI-PROJECT-19K06382, KAKENHI-PROJECT-19H03146, KAKENHI-PROJECT-21K05989
[Journal Article] Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-192021
- Author(s)
  Kaku Y, Kuwata T, Zahid HM, Hashiguchi T, Noda T, Kuramoto N, Biswas S, Matsumoto K, Shimizu M, Kawanami Y, Shimura K, Onishi C, Muramoto Y, Suzuki T, Sasaki J, Nagasaki Y, Minami R, Motozono C, Toyoda M, Takahashi H, Kishi H, Fujii K, Tatsuke T, Ikeda T, Maeda Y, Ueno T, Koyanagi Y, Iwagoe H, Matsushita S.
- Journal Title
  
  Cell Reports
  
  Volume: 36 Issue: 2 Pages: 109385-109385
- DOI
  10.1016/j.celrep.2021.109385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06401, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-19K08932, KAKENHI-PROJECT-20K20596, KAKENHI-PLANNED-20H05773
[Journal Article] Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors2021
- Author(s)
  Kobayakawa Takuya、Tsuji Kohei、Konno Kiju、Himeno Ai、Masuda Ami、Yang Tingting、Takahashi Kohei、Ishida Yusuke、Ohashi Nami、Kuwata Takeo、Matsumoto Kaho、Yoshimura Kazuhisa、Sakawaki Hiromi、Miura Tomoyuki、Harada Shigeyoshi、Matsushita Shuzo、Tamamura Hirokazu
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 3 Pages: 1481-1496
- DOI
  10.1021/acs.jmedchem.0c01153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-18K08458, KAKENHI-PROJECT-19K22488, KAKENHI-PROJECT-19H03146, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21K08501
[Journal Article] 抗体療法を目指した変異株に有効なSARS-CoV-2中和モノクローナル抗体の分離2021
- Author(s)
  郭　悠、桑田岳夫、松下修三、
- Journal Title
  
  ウイルス
  
  Volume: 71
- Data Source
  KAKENHI-PROJECT-21H02970
[Journal Article] Phenotypic and Genotypic Co-receptor Tropism Testing in HIV-1 Epidemic Region of Tanzania Where Multiple Non-B Subtypes Co-circulate2021
- Author(s)
  Judicate George P.、Barabona Godfrey、Kamori Doreen、Mahiti Macdonald、Tan Toong Seng、Ozono Seiya、Mgunya Amina Shaban、Kuwata Takeo、Matsushita Shuzo、Sunguya Bruno、Lyamuya Eligius、Tokunaga Kenzo、Ueno Takamasa
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 12 Pages: 703041-703041
- DOI
  10.3389/fmicb.2021.703041
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03703, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21K07060, KAKENHI-PROJECT-21K19657
[Journal Article] Existence of replication-competent minor variants with different coreceptor usage in plasma from HIV-1-infected individuals2020
- Author(s)
  Maeda Y, Takemura T, Chikata T, Kuwata T, Terasawa H, Fujimoto R, Kuse N, Akahoshi T, Murakoshi H, Van Tran G, Zhang Y, Pham CH, Pham AHQ, Monde K, Sawa T, Matsushita S, Nguyen TV, Van Nguyen K, Hasebe F, Yamashiro T, Takiguchi M.
- Journal Title
  
  Journal of Virology
  
  Volume: 94 Issue: 12
- DOI
  10.1128/jvi.00193-20
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08932, KAKENHI-PROJECT-16K09938, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032
[Journal Article] Specific Substitutions in Region V2 of gp120 env confer SHIV Neutralisation Resistance2020
- Author(s)
  Pisil Yalcin、Yazici Zafer、Shida Hisatoshi、Matsushita Shuzo、Miura Tomoyuki
- Journal Title
  
  Pathogens
  
  Volume: 9 Issue: 3 Pages: 181-181
- DOI
  10.3390/pathogens9030181
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-19H03146
[Journal Article] Prediction of Contact Residues in Anti-HIV Neutralizing Antibody by Deep Learning2020
- Author(s)
  Kaku Yu、Kuwata Takeo、Gorny Miroslaw K.、Matsushita Shuzo
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 73 Issue: 3 Pages: 235-241
- DOI
  10.7883/yoken.JJID.2019.496
- NAID
  130007845455
- ISSN
  1344-6304, 1884-2836
- Year and Date
  2020-05-29
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032
[Journal Article] Synergistic inhibition of cell-to-cell HIV-1 infection by combinations of single chain variable fragments and fusion inhibitors2019
- Author(s)
  Alam Mohammad Mamun、Kuwata Takeo、Tanaka Kazuki、Alam Muntasir、Takahama Shokichi、Shimura Kazuya、Matsuoka Masao、Fukuda Natsuki、Morioka Hiroshi、Tamamura Hirokazu、Matsushita Shuzo
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 20 Pages: 100687-100687
- DOI
  10.1016/j.bbrep.2019.100687
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04105, KAKENHI-PROJECT-18H02854
[Journal Article] The role of conventional antibodies targeting the CD4 binding site and CD4-induced epitopes in the control of HIV-1 CRF01_AE viruses.2019
- Author(s)
  Thida W, Kuwata T, Maeda Y, Yamashiro T, Tran GV, Nguyen KV, Takiguchi M, Gatanaga H, Tanaka K, Matsushita S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 508 Issue: 1 Pages: 46-51
- DOI
  10.1016/j.bbrc.2018.11.063
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09938, KAKENHI-PROJECT-15H02658, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-19K08932, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-16H02775
[Journal Article] Osteoporosis-related fractures in HIV-infected patients receiving long-term tenofovir disoproxil fumarate: an observational cohort study2018
- Author(s)
  Komatsu, A., Ikeda, A., Kikuchi, A., Minami, C., Tan, M., Matsushita, S.
- Journal Title
  
  Drug Safety
  
  Volume: 印刷中 Issue: 9 Pages: 843-848
- DOI
  10.1007/s40264-018-0665-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-18H02854
[Journal Article] Total HIV-1 DNA dynamics and influencing factors in long-term ART-treated Japanese adults: a retrospective longitudinal analysis.2018
- Author(s)
  Stanoeva KR, König A, Fukuda A, Kawanami Y, Kuwata T, Satou Y, Matsushita S.
- Journal Title
  
  J Acquir Immune Defic Syndr
  
  Volume: - Issue: 2 Pages: 239-247
- DOI
  10.1097/qai.0000000000001662
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09016, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-18H02854
[Journal Article] Flexibility of small molecular CD4 mimics as HIV entry inhibitors.2018
- Author(s)
  KOBAYAKAWA T, OHASHI N, HIROTA Y, TAKAHASHI K, YAMADA Y, NARUMI T, YOSHIMURA K, MATSUSHITA S, HARADA S, TAMAMURA H
- Journal Title
  
  Bioorganic & Medical Chemistry
  
  Volume: 26 Issue: 21 Pages: 5664-5671
- DOI
  10.1016/j.bmc.2018.10.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08458, KAKENHI-PROJECT-18H02854
[Journal Article] Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages2018
- Author(s)
  Siddiqui Rokeya、Suzu Shinya、Ueno Mikinori、Nasser Hesham、Koba Ryota、Bhuyan Farzana、Noyori Osamu、Hamidi Sofiane、Sheng Guojun、Yasuda-Inoue Mariko、Hishiki Takayuki、Sukegawa Sayaka、Miyagi Eri、Strebel Klaus、Matsushita Shuzo、Shimotohno Kunitada、Ariumi Yasuo
- Journal Title
  
  PLOS Pathogens
  
  Volume: 14 Issue: 11 Pages: 1007372-1007372
- DOI
  10.1371/journal.ppat.1007372
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08870, KAKENHI-PROJECT-18K08438, KAKENHI-PROJECT-18H02452, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18J00112
[Journal Article] Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes2017
- Author(s)
  T1.Tanaka, K., Kuwata, T., Alam, M., Kaplan., G, Takahama, S., Valdez, K.P.R., Roitburd-Berman, A., Gershoni. J.M., Matsushita, S.
- Journal Title
  
  Retrovirology
  
  Volume: 14 Issue: 1 Pages: 44-59
- DOI
  10.1186/s12977-017-0369-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04870
[Journal Article] The Prevalence of High Antiretroviral Coverage and Viral Suppression in Japan: an Excellent Profile for a Downstream Human Immunodeficiency Virus Care Spectrum2017
- Author(s)
  Miyazaki, N., Sugiura, W., Gatanaga, H., Watanabe, D., Yamamoto, Y., Yokomaku, Y., Yoshimura, K., Matsushita, S.
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 70 Issue: 2 Pages: 158-160
- DOI
  10.7883/yoken.JJID.2015.599
- NAID
  130005475411
- ISSN
  1344-6304, 1884-2836
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04870
[Journal Article] A minimally cytotoxic CD4 mimic as an HIV entry inhibitor2016
- Author(s)
  Takaaki Mizuguchi, Shigeyoshi Harada, Tomoyuki Miura, Nami Ohashi, Tetsuo Narumi, Hiromi Mori, Yu Irahara, Yuko Yamada, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 26 Issue: 2 Pages: 397-400
- DOI
  10.1016/j.bmcl.2015.11.103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26105721, KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-26670053, KAKENHI-PUBLICLY-16H01420, KAKENHI-PROJECT-16H04682, KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-16K01931
[Journal Article] Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.2016
- Author(s)
  Nami Ohashi1, Shigeyoshi Harada, Takaaki Mizuguchi1, Yu Irahara1, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura.
- Journal Title
  
  Chem Med Chem
  
  Volume: 19 Issue: 8 Pages: 940-946
- DOI
  10.1002/cmdc.201500590
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-26670053, KAKENHI-PUBLICLY-16H01420, KAKENHI-PROJECT-16K01931, KAKENHI-PROJECT-16K15139
[Journal Article] Impact of the Maraviroc-Resistant Mutation M434I in the C4 Region of HIV-1 gp120 on Sensitivity to Antibody-Mediated Neutralization2016
- Author(s)
  Samatchaya Boonchawalit, Shigeyoshi Harada, Noriko Shirai, Hiroyuki Gatanaga, Shinichi Oka, Shuzo Matsushita, Kazuhisa Yoshimura.
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 69 Issue: 3 Pages: 236-243
- DOI
  10.7883/yoken.JJID.2015.310
- NAID
  130005151997
- ISSN
  1344-6304, 1884-2836
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-15H04870
[Journal Article] Incompatible Natures of the HIV-1 Envelope in Resistance to the CCR5 Antagonist Cenicriviroc and to Neutralizing Antibodies2016
- Author(s)
  Kuwata T, Enomoto I, Baba M, Matsushita S
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 60 Issue: 1 Pages: 437-450
- DOI
  10.1128/aac.02285-15
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430091, KAKENHI-PROJECT-15H04870
[Journal Article] Generation of a neutralization-resistant CCR5 tropic SHIV-MK38 molecular clone, a derivative of SHIV-89.6.2016
- Author(s)
  Ishida Yuki, Yoneda Mai, Otsuki Hiroyuki, Watanabe Yuji, Kato Fumihiro, Matuura Kanako, Kikukawa Minako, Matsushita Shuzo, Hishiki Takayuki, Igarashi Tatsuhiko, Miura Tomoyuki.
- Journal Title
  
  J Gen Virol
  
  Volume: 97(5) Issue: 5 Pages: 1249-60
- DOI
  10.1099/jgv.0.000421
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19109, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-16H04682
[Journal Article] Cross-Neutralization Activity of Single-Chain Variable Fragment (scFv) Derived from Anti-V3 Monoclonal Antibodies Mediated by Post-Attachment Binding2016
- Author(s)
  Maruta, Y., Kuwata, T., Tanaka, K., Alam, M., Valdez, K. P., Egami, Y., Yoshiaki Suwa, Y., Morioka, H. and Matsushita, S.
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 69 Issue: 5 Pages: 395-404
- DOI
  10.7883/yoken.JJID.2015.667
- NAID
  130005416280
- ISSN
  1344-6304, 1884-2836
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430091, KAKENHI-PROJECT-15H04870
[Journal Article] Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors2016
- Author(s)
  Alam, M., Kuwata, T., Shimura, K., Yokoyama, M., Ramirez Valdez, K. P., Tanaka, K., Maruta, Y., Oishi, S., Fujii, N., Sato, H., Matsuoka M. and Matsushita S.
- Journal Title
  
  Retrovirology
  
  Volume: 13 Issue: 1 Pages: 70-70
- DOI
  10.1186/s12977-016-0304-7
- NAID
  120005973385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430091, KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-15H04654, KAKENHI-PROJECT-15H04870
[Journal Article] Passive transfer of neutralizing monoclonal antibody KD-247reduces plasma viral load in patients chronically infected with HIV-1.2015
- Author(s)
  Matsushita, S., Yoshimura, K., Ramirez, K.P., Pisupati, J., Murakami, T.
- Journal Title
  
  AIDS
  
  Volume: 29 Issue: 4 Pages: 453-462
- DOI
  10.1097/qad.0000000000000570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains.2015
- Author(s)
  Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S.
- Journal Title
  
  Virology
  
  Volume: 475 Pages: 187-203
- DOI
  10.1016/j.virol.2014.11.011
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-26430091
[Journal Article] Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247.2015
- Author(s)
  Kirby, K.A., Ong Y.T., Hachiya, A., Laughlin, T.G.,Chiang, L.A., Pan Y., Moran, J.L., Marchand, B.,Singh, K., Gallazzi, F., Quinn, T.P., Yoshimura, K., Murakami, T., Matsushita S., Sarafianos, S.G.
- Journal Title
  
  The FASEB Journal
  
  Volume: 29 Issue: 1 Pages: 1-11
- DOI
  10.1096/fj.14-252262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Impact of maraviroc-resistant and low-CCR5- adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies.2014
- Author(s)
  Kazuhisa Yoshimura, Shigeyoshi Harada, Samatchaya Boonchawalit, Yoko Kawanami, Shuzo Matsushita.
- Journal Title
  
  Journal of General Virology
  
  Volume: 95 Issue: 8 Pages: 1816-1826
- DOI
  10.1099/vir.0.062885-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Small molecular CD4 mimics as HIV entry inhibitors2011
- Author(s)
  Narumi, T., Arai, H., Yoshimura, K., Harada, S., Nomura, W., Matsushita, S., Tamamura. H.
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 19 Pages: 6735-6742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591295
[Journal Article] CD4 mimics targeting the mechanism of HIV entry2010
- Author(s)
  Yamada, Y., Ochiai, C., Yoshimura, K., Tanaka, T., Ohashi, N., Narumi T., Nomura, W., Harada, S., Matsushita, S., Tamamura, H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 20 Pages: 354-358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591295
[Journal Article] HIV-1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V22010
- Author(s)
  Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., Matsushita S.
- Journal Title
  
  J. Gen. Virol
  
  Volume: 91 Pages: 1335-1345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591295
[Journal Article] CD4mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist2010
- Author(s)
  Narumi, T., Ochiai, C., Yoshimura, K., Harada, S., Tanaka, T., Nomura, W., Arai, H., Ozaki, T., Ohashi, N., Matsushita, S., Tamamura, H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Pages: 5853-5858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591295
[Journal Article] Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds2010
- Author(s)
  Yoshimura, K., Harada, S., Shibata, J., Hatada, M., Yamada, Y., Ochiai, C., Tamamura, H., Matsushita, S.
- Journal Title
  
  J. Virol
  
  Volume: 84 Pages: 7558-7568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591295
[Journal Article] The anti-retroviral potency of APOBEC1 deaminase from small animal species2008
- Author(s)
  Ikeda, T., Ohsugi, T., Kimura, T., Matsushita, S., Maeda, Y., Harada, S., Koito, A.
- Journal Title
  
  Nucleic Acids Research 36(21)
  
  Pages: 6859-6871
- Data Source
  KAKENHI-PROJECT-18591119
[Journal Article] SOCS1 is an inducible host factor during HIV-1 infection the intracellular trafficking and stability of HIV-1 Gag2008
- Author(s)
  Ryo, A., Tsurutani, N., Ohba, K., Kimura, R., Komano, J., Nishi, M., Hiromi Soeda, Hattori, S., Perrem, K., Yamamoto, M., Chiba, J., Mimaya, J., Yoshimura, K., Matsushita, S., Honda, M., Yoshimura, A., Sawasaki, T., Aoki, I., Morikawa, Y., Yamamoto, N.
- Journal Title
  
  Proc Natl Acad Sci U S A 105
  
  Pages: 294-299
- Data Source
  KAKENHI-PROJECT-18591119
[Journal Article] Wild type and H43Y variant of human TRIM5α show similar anti-human immunodeficiency virus type 1 activity both in vivo and in vitro2007
- Author(s)
  Nakayama, E.E., Carpentier, W., Costagliola, D., Shioda, T., Iwamoto, A., Debre, P, Yoshimura, K., Autran, B., Matsushita, S., Theodorou, I
- Journal Title
  
  Immunogenetics 59
  
  Pages: 511-515
- Data Source
  KAKENHI-PROJECT-18591119
[Journal Article] Successful efavirenz dose reduction in HIV-1-infeccted individuals with cytochrome P450 2B6*6 and *262007
- Author(s)
  Gatanaga, H., Hayashida, T., Tsuchiya, K., Yoshino, M., Kuwahara, T., Tsukada, H., Fujimoto, K., Sato, I., Ueda, M., Horiba, M., Hamaguchi, M., Yamamoto, M., Takata, N., Kimura, A., Koike, T., Gejyo, F., Matsushita, S., Shirasaka,T., Kimura, S., Oka, S.
- Journal Title
  
  Clinical Infectious Diseases 45
  
  Pages: 1230-1237
- Data Source
  KAKENHI-PROJECT-18591119
[Journal Article] Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective HAART2007
- Author(s)
  Ikeda, T., Shibata, J., Yoshimura, K., Koito, K., Matsushita, S.
- Journal Title
  
  J. Infect. Dis 195
  
  Pages: 716-725
- Data Source
  KAKENHI-PROJECT-18591119
[Journal Article] Impact of V2 mutations for escape from a potent neutralizing anti-V3 monoclonal antibody during in vitro selection of a primary HIV-1 isolate2007
- Author(s)
  Shibata, J., Yoshimura, K., Honda, A., Koito, A., Murakami, T., Matsushita, S.
- Journal Title
  
  J. Virol 81
  
  Pages: 3757-3768
- Data Source
  KAKENHI-PROJECT-18591119
[Journal Article] Anti-V3 humanized antibody KD-247 effectively suppresses ex vivo generation of human immunodeficiency virus type 1 and affords sterile protection of monkeys against a heterologous simian/human immunodeficiency virus infection2006
- Author(s)
  Eda, Y., Murakami, T., Ami, Y., Nakasone, T., Takizawa, M., Someya, K., Kaizu, M., Izumi, Y., Yoshino, N., Matsushita, S., Higuchi, H., Matsui, H., Shinohara, K., Takeuchi, H., Koyanagi, S., Yamamoto, N., Honda M.
- Journal Title
  
  J. Virol 80
  
  Pages: 5563-5570
- Data Source
  KAKENHI-PROJECT-18591119
[Journal Article] Resistance profile of a novelbroadly neutralizing anti-HIV monoclonal antibody, KD-247, thatshows favorable synergism withanti-CCR5 inhibitors in vitro2006
- Author(s)
  Yoshimura, K., Shibata, J., Kimura, T.,Honda, A., Maeda, Y., Koito, A.,Murakami, T., Mitsuya, H., Matsushita,S
- Journal Title
  
  AIDS 20
  
  Pages: 2065-2073
- Data Source
  KAKENHI-PROJECT-18591119
[Journal Article] Sequential immunization with V3 peptides from primary HIV-1 produces cross-neutralizing antibodies against primary isolates with matching narrow neutralization sequence motif2006
- Author(s)
  Eda, Y., Takizawa, M., Murakami, T., Maeda, H., Kimachi, K., Yonemura, H., Koyanagi, S., Shiosaki, K., Higuchi, H., Makizumi, K., Nakashima, T., Osatomi, K., Tokiyoshi, S., Matsushita, S., Yamamoto, N., Honda, M
- Journal Title
  
  J. Virol 80
  
  Pages: 5552-5562
- Data Source
  KAKENHI-PROJECT-18591119
[Patent] 抗HIV抗体の製造方法2019
- Inventor(s)
  松下修三、桑田岳夫、清水衛、冨田正浩、道下眞弘
- Industrial Property Rights Holder
  松下修三、桑田岳夫、清水衛、冨田正浩、道下眞弘
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02854
[Patent] 抗HIV-1 V3抗体1C10（0.5γ）に結合する抗体及びその抗原結合断片並びにその応用2019
- Inventor(s)
  松下修三、桑田岳夫、郭悠
- Industrial Property Rights Holder
  松下修三、桑田岳夫、郭悠
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-180305
- Filing Date
  2019
- Acquisition Date
  2019
- Data Source
  KAKENHI-PROJECT-18H02854
[Patent] 抗HIV抗体及びその製造方法2019
- Inventor(s)
  松下修三、桑田岳夫、清水衛、冨田正浩、道下眞弘
- Industrial Property Rights Holder
  松下修三、桑田岳夫、清水衛、冨田正浩、道下眞弘
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02854
[Patent] 抗HIV抗体の製造方法2018
- Inventor(s)
  松下修三；桑田岳夫; 清水　衛; 冨田正浩; 道下眞弘
- Industrial Property Rights Holder
  松下修三；桑田岳夫; 清水　衛; 冨田正浩; 道下眞弘
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-203114
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18H02854
[Patent] 抗HIVモノクローナル抗体2008
- Inventor(s)
  松下修三
- Industrial Property Rights Holder
  熊本大学
- Filing Date
  2008-11-19
- Overseas
- Data Source
  KAKENHI-PROJECT-18591119
[Patent] 抗HIVモノクローナル抗体2007
- Inventor(s)
  松下修三
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Number
  2007-299083
- Filing Date
  2007-11-19
- Data Source
  KAKENHI-PROJECT-18591119
[Patent] 抗HIVモノクローナル抗体2007
- Inventor(s)
  松下修三
- Industrial Property Rights Holder
  熊本大学
- Filing Date
  2007-11-19
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] N-backタスクにおける行動・生理特徴量の解析に関する基礎研究～ANI早期発見への応用～2024
- Author(s)
  鶴味詢大, 山口武彦, 松下修三, 山之内純, 中尾綾, 中田浩智, 南留美, 坂本麻衣子
- Organizer
  第33回ライフサポート学会フロンティア講演会
- Data Source
  KAKENHI-PROJECT-21K03088
[Presentation] タブレット型VR-IADLにおけるmicro-errorの評価：ANI早期発見への応用2024
- Author(s)
  野口歩夢, 山口武彦, 松下修三, 山之内純, 中田浩智, 南留美, 坂本麻衣子
- Organizer
  第33回ライフサポート学会フロンティア講演会
- Data Source
  KAKENHI-PROJECT-21K03088
[Presentation] A Novel Touch-Panel Screening Battery for Detecting HIV-Related Neurocognitive Impairment.2024
- Author(s)
  Sakamoto M, Tsurumi J, Nakao A, Yamanouchi J, Nakata H, Minami R, Matsushita S, Giovannetti T & Yamaguchi T.
- Organizer
  52nd International Neuropsychological Society Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K03088
[Presentation] COVID-19回復者におけるSARS-CoV-2変異株を交差中和する抗体の誘導2023
- Author(s)
  桑田岳夫、郭悠、清水美紀子、Shashwata Biswas、松本佳穂、松下修三
- Organizer
  第１回新型コロナウイルス研究集会
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] HANDスクリーニング指標としてのmicro-errorsの有用性2023
- Author(s)
  柏崎嵩斗, 山口武彦, 松下修三, 山之内純, 中田浩智, 南留美, 坂本麻衣子
- Organizer
  第32回ライフサポート学会フロンティア講演会
- Data Source
  KAKENHI-PROJECT-21K03088
[Presentation] Isolation of monoclonal antibodies with neutralization and ADCC activities against SARS- CoV-2 variants2023
- Author(s)
  Matsumoto K, Kuwata T, Kaku Y, Amano M, Shimizu M, Biswas S, Matsushita S
- Organizer
  24th Kumamoto AIDS Seminar
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] SARS-CoV-2 Delta株ブレイクスルー感染例から分離した抗体の交差中和活性2023
- Author(s)
  桑田岳夫、郭悠、清水美紀子、 Biswas Shashwata、松本佳穂、 Khairy Hamdy Edri Ahmed、松下修三
- Organizer
  第37回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] The CD4 mimetic compound YIR-821 is broadly effective against HIV-1 clinical strains.2022
- Author(s)
  Kaho Matsumoto, Takeo Kuwata, Shokichi Takahama, George P Judicate, Takamasa Ueno, Takuya Kobayakawa, Kohei Tsuji, Hirokazu Tamamura and Shuzo Matsushita.
- Organizer
  24th Kumamoto AIDS Seminar
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] タブレット版HANDスクリーニング検査の妥当性と有用性2022
- Author(s)
  坂本麻衣子,中尾綾,小山璃久, 鶴味詢大, 山之内純, 中田浩智, 松下修三, 南留美, 山口武彦
- Organizer
  第36回日本エイズ学会
- Data Source
  KAKENHI-PROJECT-21K03088
[Presentation] 2-Back タスクにおける健常者と HIV 感染者の振る舞いの相違性2022
- Author(s)
  鶴味詢大, 山口武彦, 松下修三, 山之内純, 中田浩智, 南留美, 坂本麻衣子
- Organizer
  第31回ライフサポート学会フロンティア講演会
- Data Source
  KAKENHI-PROJECT-21K03088
[Presentation] Antibodies against CD4 induced epitope of HIV-1 evolve from B cells primed by gut microbiome2022
- Author(s)
  Shashwata Biswas, Kyo Okazaki, Soichiro Yamauchi, Takeo Kuwata, Hiroshi Morioka and Shuzo Matsushita.
- Organizer
  24th Kumamoto AIDS Seminar
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] 高臨場感 VR 環境を用いた IADL パフォーマンスにおける Micro-error の計測可能性の評価2022
- Author(s)
  町田翔真, 山口武彦, 林那由斗, 松下修三, 山之内純, 中田浩智, 南留美, 坂本麻衣子
- Organizer
  第31回ライフサポート学会フロンティア講演会
- Data Source
  KAKENHI-PROJECT-21K03088
[Presentation] CD4類似化合物YIR-821の臨床株に対する有効性の検討2022
- Author(s)
  松本佳穂, 桑田岳夫, 高濱正吉, Judicate GP, 上野貴将, 小早川拓也, 玉村啓和, 松下修三.
- Organizer
  第30回抗ウイルス療法学会学術集会総会
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] CD4 類似化合物YIR-821は多くのHIV-1臨床株に有効である2022
- Author(s)
  松本佳穂, 桑田岳夫, 高濱正吉 , Judicate GP, 上野貴将, 小早川拓也, 玉村啓和, 松下修三.
- Organizer
  第36回日本エイズ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] CD4類似化合物YIR-821によるサブタイプB HIV-1患者抗体の活性増強効果2021
- Author(s)
  松本佳穂、桑田岳夫、Zahid Md H、郭悠、Biswas S、高濱正吉、玉村啓和、松下修三
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] Anti-Idiotype antibodies as sorting probes to isolate anti-CD4i antibodies2021
- Author(s)
  Biswas S, Yamauchi S, Morioka H, Kaku Y, Kuwata T, Matsushita S
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] COVID-19回復者で誘導された抗体に対するSARS-CoV-2変異株の中和抵抗性2021
- Author(s)
  桑田岳夫、郭悠、清水美紀子、Zahid Md H、Biswas S、松本佳穂、松下修三
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] タブレット版HANDスクリーニング検査の開発2021
- Author(s)
  坂本麻衣子, 小山璃久,中尾綾, 鶴味詢大, 山之内純, 中田浩智, 松下修三, 山本政弘, 南留美, 山口武彦
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21K03088
[Presentation] タブレット版HANDスクリーニング検査の開発2021
- Author(s)
  坂本麻衣子, 小山璃久,中尾綾, 鶴味詢大, 山之内純, 中田浩智, 松下修三, 山本政弘, 南留美, 山口武彦
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K03100
[Presentation] 回復患者より抽出したSARS-CoV-2中和抗体の検討2021
- Author(s)
  郭悠、松本佳穂、Zahid Md H、Biswas S、桑田岳夫、松下修三
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] 抗イディオタイプ抗体を用いたHIV中和抗体誘導の為の段階的ワクチン戦略2021
- Author(s)
  郭悠、Zahid Md H、Biswas S、松本佳穂、桑田岳夫、松下修三
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21H02970
[Presentation] VRを用いた日本版手段的日常生活動作評価システムの開発：HIV関連神経認知障害の早期発見技術への応用2019
- Author(s)
  内河道久，戸島拓海，山口武彦，Tania Giovannetti, 松下修三，宮川寿一，山本正弘，坂本麻衣子
- Organizer
  第28回ライフサポート学会フロンティア講演会
- Data Source
  KAKENHI-PROJECT-18K03100
[Presentation] Synergistic Inhibition of cell-to-cell infection of HIV-1 by thecombination of single chain fragment variables (scFvs) and fusion inhibitors.2019
- Author(s)
  Mohammad Mamun Alam, Takeo Kuwata, Kazuki Tanaka, Muntasir Alam, Shokichi Takahama, Kazuya Shimura, Masao Matsuoka, Natsuki Fukuda, Hiroshi Morioka, Hirokazu Tamamura and Shuzo Matsushita
- Organizer
  10th IAS Conference on HIV Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] Isolation of a monoclonal antibody from a patient infected with HIV-1 subtype AG2019
- Author(s)
  Hasan MD Zahid, Kaku Yu, Kazuki Tanaka, Takahama Shokichi, Kuwata, Takeo., Matsushita Shuzo.
- Organizer
  第33回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] Anti-idiotype antibodies of neutralizing antibodies targeting CD4-induced (CD4i) epitope on HIV-1 gp120.2019
- Author(s)
  Shashwata B., Tanaka K., Kaku Y., Kuwata T., Matsushita S.
- Organizer
  第33回日本エイズ学会・学術集会総会
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] single cell sortingとdeep learningを用いた抗イディオタイプ抗体による抗V3 loop抗体分化の系統学的検討.2019
- Author(s)
  郭悠, MD Hassan Zahid, Shashwata Biswas, 桑田岳夫, 松下修三.
- Organizer
  第33回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] VH gene polymorphism associated with potent anti-SIV neutralizing antibody induction.2019
- Author(s)
  Kuwata T, Ishii H, Matsuoka S, Sekizuka T, Kuroda M, Harada S, Matsushita S, Seki Y, Sakawaki H, Miura T, Akari H, Matano T.
- Organizer
  The Conference on Retroviruses and Opportunistic Infections (CROI 2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] Analysis of the envelope gene in the patient treated with maraviroc2018
- Author(s)
  Lin K H, Kuwata T, Thida W, Shimizu M and Matsushita S
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] Role of Conventional Antibodies in Control of HIV-1 CRF01_AE viruses2018
- Author(s)
  Thida W, Kuwata T, Maeda Y, Tran G V, Nguyen K V, Takiguchi M, Gatanaga H and Matsushita S
- Organizer
  HIV Research for Prevention 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] Synergistic inhibition by single chain fragment variables and fusion inhibitors in both cell-free and cell-associated HIV-1 infections2018
- Author(s)
  Mamun M A, Maruta Y, Tanaka K, Alam M, Thida W, Takahama S, Kuwata T and Matsushita S
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] Synergistic inhibition of both cell-free and cell-associated HIV-1 infections by single chain fragment variables and fusion inhibitors.2018
- Author(s)
  Mamun M., Maruta Y., Tanaka K., Muntasir A, Thida W., Takahama S., Kuwata T., Shimura K., Matsuoka M., Tamamura H., Matsushita S.
- Organizer
  19th Kumamoto AIDS seminar.
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] ADCC activity of HIV-1 Env-specific monoclonal antibodies against subtype B and CRF01_AE viruses from Japan and Vietnam.2018
- Author(s)
  Thida W., Kuwata T., Maeda Y., Yamashiro T., Tran G.V., Nguyen K.V., Takiguchi M., Gatanaga H., Tanaka K., Matsushita S.
- Organizer
  19th Kumamoto AIDS seminar
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] Development of anti-idiotypic antibodies for neutralizing antibodies against V3-loop of HIV-1.2018
- Author(s)
  Kaku Y., Tanaka K., Shashwata B., Hassan Z., Kuwata T., Matsushita S.
- Organizer
  19th Kumamoto AIDS seminar
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] 抗イディオタイプ抗体による抗V3中和単クローン抗体産生B細胞単離方法の検討2018
- Author(s)
  郭悠、桑田岳夫、田中和樹、Biswas Shashwata、Zahid MD Hassan、松下修三
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18H02854
[Presentation] Single cell sorting による抗 V3 中和単クローン抗体に対する抗イディオタイプ.2017
- Author(s)
  郭悠, 桑田岳夫, 田中和樹, Alam Mohammad Mamun, 高濱正吉, Hassan MD Zahid, 松下修三.
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Broadly neutralizing antibody for treatment and prevension of HIV infetion.2017
- Author(s)
  Shuzo Matsushita
- Organizer
  ISAAR & ICIC 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Neutralization sensitivities of clade B and CRF01_AE viruses of HIV-1 isolated from patients with recent diagnosis in Japan.2017
- Author(s)
  Thida, W., Kuwata T., Muntasir A., Tanaka K., Mamun M., Shimizu, M., Kawanami, Y., Matsushita S.
- Organizer
  18th Kumamoto AIDS seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Evaluation of Binding affinity and Neutralization Potency and coverage of anti-V3 scFv’sagainst HIV-1 subtype-B viruses.2017
- Author(s)
  Alam Mohammad, 田中和樹, Muntasir Alam, Win Thida, 桑田岳夫, 松下修三.
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Evaluation of Binding affinity and kinetics, Neutralization Potency and Coverage of anti-V3 scFv’s against HIV-1 Subtype-B viruses in vitro.2017
- Author(s)
  Mamun M., Maruta Y., Tanaka K., Muntasir A., Thida, W., Kuwata T., Matsushita S.
- Organizer
  18th Kumamoto AIDS seminar.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Dynamics of HIV-1 DNA in long-term treated patients with hematological co-morbidities2016
- Author(s)
  Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T, Satou Y, Matsushita S
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Post-attachment Neutralization of a Wide Range of HIV-1 Strains by Anti-CD4i Single Chain Variable Fragment (scFv)2016
- Author(s)
  Tanaka K, Kuwata T, Maruta Y, Ramirez Valdez K P, Alam M, Kawanami Y, Matsushita S
- Organizer
  HIVR4P 2016
- Place of Presentation
  Chicago, USA
- Year and Date
  2016-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Incompatibility of HIV-1 Resistance to Both Cenicriviroc and Neutralizing Antibodies2016
- Author(s)
  Kuwata T, Enomoto I, Baba M and Matsushita S
- Organizer
  The annual Conference on Retroviruses and Opportunistic Infections
- Place of Presentation
  Boston, USA
- Year and Date
  2016-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Analysis and characterization of HIV-1 envelope glycoprotein in Japanese patients with recent diagnosis2016
- Author(s)
  Thida W, Kuwata T, Alam M, Tanaka K, Maun M, Shimizu M, Kawanami Y and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] HIV proviral DNA quantification in a cohort of Japanese patients on longterm ART2016
- Author(s)
  K. Stanoeva, A. Konig, A. Fukuda, Y. Kawanami, T. Kuwata, Y. Satou, S. Matsushita.
- Organizer
  21st International AIDS Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] PM1/CCR5 cells transduced with T312 Intrabody have survival advantage, if challenged with SF162 HIV-1 strain2016
- Author(s)
  Alves G, Kuwata T, Tanaka Y, Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] HIV proviral DNA quantification in a cohort of Japanese patients on long-term ART2016
- Author(s)
  Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T, Satou Y, Matsushita S
- Organizer
  2016 Towards an HIV Cure Symposium
- Place of Presentation
  Durban, South Africa
- Year and Date
  2016-07-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Induction of antibodies, which belonged to the same class as broadly neutralizing antibody B404, in macaques infected with SIVsmH635FC2016
- Author(s)
  Kuwata T, Sano M, Matsuoka S, Shimizu M, Miura T, Seki Y, Akari H, Matano T and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Total HIV DNA levels dynamics upon ART initiation2016
- Author(s)
  Stanoeva KR., Konig A., Fukuda A., Kawanami Y., Kuwata T., Satou Y., Matsushita S.
- Organizer
  2nd Kumamoto IRCMS International Symposium.17th Kumamoto AIDS seminar
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Increased total HIV DNA levels in long-term treated patients with hemophilia.2016
- Author(s)
  Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T, Satou Y., Matsushita S.
- Organizer
  第30回日本エイズ学会学術集会・総会.
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Incompatibility of HIV-1 Resistance to Both Cenicriviroc and Neutralizing Antibodies Boston, Massachusetts.2016
- Author(s)
  Kuwata,T., Enomoto I., Baba M., Matsushita S.
- Organizer
  Conference on Retroviruses and Opportunistic Infections
- Place of Presentation
  Boston, USA
- Year and Date
  2016-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Construction, purification and analysis of neutralization potency of anti-V3 scFv’s against HIV-1 strains in vitro2016
- Author(s)
  Mamun M, Maruta Y, Tanaka K, Alam M, Thida W, Kuwata T and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] CD4+T細胞の分化に対するHIV感染とmiR125bの影響の検討2016
- Author(s)
  郭悠、南留美、小松真梨子、高濱宗一郎、高濱正吉、桑田岳夫、山本政弘、松下修三
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Isolation and characterization of HIV-1 envelope glycoprotein in Japanese patients with recent diagnosis.2016
- Author(s)
  Thida W., Kuwata T., Muntasir A., Tanaka K., Mamun M., Shimuzu M., Kawanami Y., Matsushita S.
- Organizer
  2nd Kumamoto IRCMS International Symposium.17th Kumamoto AIDS seminar
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Post-attachment neutralization of a broad range of HIV-1 strains by the small antibody fragments targeting CD4-induced (CD4i) epitope2016
- Author(s)
  Tanaka K, Kuwata T, Takahama S, Alam M, Maruta Y, Ramirez Valdez K P, Shimizu M, Kawanami Y and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Construction, purification and analysis of neutralization potency of anti-V3 scFv’s against HIV-1 strains in vitro.2016
- Author(s)
  Mamun M., Maruta Y., Tanaka K., Muntasir A., Thida W., Kuwata T., Matsushita S.
- Organizer
  2nd Kumamoto IRCMS International Symposium.17th Kumamoto AIDS seminar
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Potent and broad neutralizing activity of small antibody fragments targeting CD4i (CD4-induced) epitope.2015
- Author(s)
  Tanaka, K., Kuwata, T., Maruta, Y., Ramirez, K., Alam, M., Egami, Ikumi Y., Enomoto, I., Kawanami, Y., Matsushita. S.
- Organizer
  The 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015)
- Place of Presentation
  Vancouver, Canada.
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] 軽度から中等度の腎機能障害があるHIV 1 感染症患者に E/C/F/TAF を投与した第 III 相臨床試験におけるアジア人での有効性及び安全性の評価.2015
- Author(s)
  松下修三、中本泰充、池田篤史、Pozniak, A、Arribas, J、Gupta, S、Post, F、Fordyce, M.
- Organizer
  第29回日本エイズ学会学術集会・総会
- Place of Presentation
  東京ドームホテル、東京
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Impact of gp41 mutations on resistance to B404, a broad neutralizing antibody reactive against a conformational epitope of SIV gp1202015
- Author(s)
  Kuwata T, Shimizu M, Matsushita S
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Mechanism of post-attachment neutralization of single-chain variable fragment (scFv) from anti-V3 monoclonal antibody　with cross-reactivity.2015
- Author(s)
  Maruta, Y., Kuwata, T., Tanaka, K., Nakahara,Y., Ramirez, K., Alam, M., Egami, Y., Hirata, I., Suwa, Y., Morioka, H., Matsushita, S.
- Organizer
  Korea-Japan Joint Seminar on HIV/AIDS.
- Place of Presentation
  熊本大学山崎記念会館（熊本市）
- Year and Date
  2015-01-10
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] ファージ・ライブラリーを用いた抗 V3単クローン抗体のエピトープ解析.2015
- Author(s)
  平田泉、桑田岳夫、丸田泰広、田中和樹、Muntasir, A.、松下修三
- Organizer
  第29回日本エイズ学会学術集会・総会
- Place of Presentation
  東京ドームホテル、東京
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Effect of gp41 mutations on the sensitivity to neutralizing antibodies against HIV.2015
- Author(s)
  Muntasir, A., Kuwata, T., Ramirez, K., Maruta, Y., Tanaka, K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushita, S.
- Organizer
  第29回日本エイズ学会学術集会・総会.
- Place of Presentation
  東京ドームホテル、東京
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Towards HIV reservoir measurements in ART-treated patients: integrated DNA quantification and HIV-1 clone expansion in a Japanese cohort.2015
- Author(s)
  Stanoeva, K, Fukuda, A, König A., Satou Y., Matsushita S.
- Organizer
  37th International Workshop HIV Persistence during Therapy
- Place of Presentation
  Miami, Florida, U.S.A.
- Year and Date
  2015-12-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Impact of gp41 mutations for escape from a broad neutralizing antibody against SIV2015
- Author(s)
  Kuwata T, Shimizu M, Matsushita S
- Organizer
  16th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] EVG/COBI/FTC/TDF 第III 相臨床試験における腎機能に関連する安全性の評価（投与96 週時点）－アジア人についての層別集計結果を含む－.2013
- Author(s)
  松下修三
- Organizer
  第27回日本エイズ学会学術集会・総会.
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Passive transfer of neutralizing monoclonal antibody KD-247 reduces plasma viral load in patients chronically infected with HIV-1：A Phase-1b clinical study of a humanized monoclonal antibody KD-247 (KD-1002).2013
- Author(s)
  Matsushita S.
- Organizer
  IAS Towards an HIV Cure Symposium.
- Place of Presentation
  Kuala Lumpur, Malaysia.
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] KD-1002 Principal Investigators and The Protocol Team of Quintiles. Passive transfer of neutralizing monoclonal antibody KD-247 reduces plasma viral load in patientschronically infected with HIV-1: a phase-1b clinical study of a humanized monoclonal antibody KD-247 (KD-1002).2013
- Author(s)
  Matsushita S.
- Organizer
  7th IAS Conference on HIV Pathogenesis, Treatment and Prevention
- Place of Presentation
  Kuala Lumpur, Malaysia.
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Maraviroc-resistant subtype B primary HIV-1 induced in vitro selection became highly sensitive to anti-gp120 neutralizing antibodies and autologous plasma IgG under high concentrations of the CCR5 inhibitor2011
- Author(s)
  Yoshimura, K., Harada, S., Hamji, A., Matsushita, S.
- Organizer
  6th IAS Conference on HIV Pathogenesis, Treatment and Prevention
- Place of Presentation
  The Auditorium Parco della Musica, Roma, Italy
- Year and Date
  2011-07-19
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Impact of raltegravir pressure on the selection of HIV-1 envelope sequences in vitro2011
- Author(s)
  Harada, S., Ishikawa, T., Hamaji, A., Matsushita, S., Yoshimura, K.
- Organizer
  12th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Aso Resort Granvilio Hotel. Aso, Kumamoto
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Construction of neutralizing antibody fragments for efficient access to V3 epitope2011
- Author(s)
  Maruta, S., Ramirez, K, Kuwata, T., Matsushita, S.
- Organizer
  12th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Aso Resort Granvilio Hotel. Aso, Kumamoto
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Impact of raltegravir pressure on the selection of HIV-1 envelope sequences in vitro2011
- Author(s)
  Harada, S., Ishikawa, T., Hamaji, A., Matsushita S., Yoshimura K.
- Organizer
  6th IAS Conference on HIV Pathogenesis, Treatment and Prevention
- Place of Presentation
  The Auditorium Parco della Musica, Roma, Italy
- Year and Date
  2011-07-19
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Two-step escape pathway of the HIV-1 primary isolates induced by the in vitro selection of maraviroc2011
- Author(s)
  Yoshimura, K., Harada, S., Hamaji, A., Matsushita, S.
- Organizer
  12th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Aso Resort Granvilio Hotel. Aso, Kumamoto
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Cross-reactivity and crossneutralizing activity of monoclonal antibody(MAbs) to CD4-induced epitope of gp120 against HIV-1B, C, CRF_01 subtype viruses2011
- Author(s)
  Ramirez, K, Maruta, Y., Kuwata, T., Yoshimura, K, Tamamura, H., Matsushita, S
- Organizer
  第25回日本エイズ学会学術集会・総会
- Place of Presentation
  ハイアットリージェンシー東京.東京都
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Isolation of potent neutralizing monoclonal antibodies against V3 loop from SIV-infected macaques2011
- Author(s)
  Kuwata, T., Igarashi, T., Matsushita, S.
- Organizer
  AIDS Vaccine 2011
- Place of Presentation
  Bankok Convention Center, Bangkok, Thailand
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Biased induction of neutralizing antibodies with particular specificity and gene usage in SIVsmH635FC-infected macaques2011
- Author(s)
  Kuwata, T., Takaki, K., Matsushita, S.
- Organizer
  12th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Aso Resort Granvilio Hotel. Aso, Kumamoto
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] HIV-1のV3領域に結合する中和抗体の遺伝子組換えによる小型化の試み2011
- Author(s)
  丸田泰広、桑田岳夫、クリステル.パオラ.ラミレス.バルデス、松下修三
- Organizer
  第25回日本エイズ学会学術集会・総会
- Place of Presentation
  ハイアットリージェンシー東京.東京都
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] HIV陽性者のメンタルヘルスへのアプローチその2メンタルヘルス問題の「今」を考える:どのように捉え、どうアプローチすることが可能だろうか?～うつと依存症(薬物)を中心に2010
- Author(s)
  松下修三
- Organizer
  第24回日本エイズ学会学術集会・総会
- Place of Presentation
  グランドプリンスホテル高輪ザ・プリンスさくらタワー東京(東京都)
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] ラルテグラビルはHIV-1のin vitro馴化におけるEnv選択に影響する2010
- Author(s)
  原田恵嘉、濱治有希、松下修三、吉村和久
- Organizer
  第24回日本エイズ学会学術集会・総会
- Place of Presentation
  グランドプリンスホテル高輪ザ・プリンス.東京都
- Year and Date
  2010-11-24
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] 最新の情報を明日の臨床に生かす-Year in review 2010-「病態の研究と治療薬開発の未来」2010
- Author(s)
  松下修三
- Organizer
  第24回日本エイズ学会学術集会・総会
- Place of Presentation
  グランドプリンスホテル高輪ザ・プリンスさくらタワー東京(東京都)
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Strategy to overcome neutralization of HIV-1 primary isolates.2010
- Author(s)
  Matsushita, S.
- Organizer
  11^<th> GCOE joint international Symposium Kumamoto AIDS Seminar
- Place of Presentation
  ホテル日航熊本(熊本市)
- Year and Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] CD4 mimetic compound-mediated enhancement of the neutralization activities of anti-V3 and CD4i monoclonal antibodies against the standard panel of primary isolates2010
- Author(s)
  Matsushita, S., Mouri, S., Harada, S., Yamada, Y., Tamamura, H., Yoshimura, K.
- Organizer
  XVIII International AIDS Conference
- Place of Presentation
  The Reed Messe Wien, Vienna, Austria
- Year and Date
  2010-07-18
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] CD4 mimetic compound-mediated enhancement of the neutralization activities of anti-V3 and CD4i monoclonal antibodies against the standard panel of primary isolates.2010
- Author(s)
  Matsushita, S.
- Organizer
  XVIII International AIDS Conference
- Place of Presentation
  The Reed Messe Wien(オーストリア・ウイーン市)
- Year and Date
  2010-07-18
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] 共催シンポジウム2最新の情報を明日の臨床に生かす-Year in review 2010-「病態の研究と治療薬開発の未来」2010
- Author(s)
  松下修三
- Organizer
  第24回日本エイズ学会学術集会・総会
- Place of Presentation
  グランドプリンスホテル高輪ザ・プリンス.東京都
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Strategy to overcome neutralization of HIV-1 primary isolates2010
- Author(s)
  Matsushita, S., Mouri, S., Harada, S., Yamada, Y., Tamamura, H., Yoshimura, K.
- Organizer
  1^<1th> GCOE joint international Symposium Kumamoto AIDS Seminar
- Place of Presentation
  Hotel Nikko Kumamoto, Kumamoto
- Year and Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Impact of a point mutation V2(L175P) in neutralization resistance mediated by functional trimer formation of Env2010
- Author(s)
  Liu, M., Shibata, J., Harada, S., Takehisa, J., Yoshimura, K., Matsushita, S.
- Organizer
  AIDS Vaccine 2010
- Place of Presentation
  The Omni Hotel at CNN Center, Atlanta, USA
- Year and Date
  2010-09-28
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] CCR5阻害剤maraviroc(MVC)耐性誘導によるEnvの変異が中和抗体感受性に及ぼす影響2010
- Author(s)
  吉村和久、原田恵嘉、濱治有希、松下修三
- Organizer
  第24回日本エイズ学会学術集会・総会
- Place of Presentation
  グランドプリンスホテル高輪ザ・プリンス.東京都
- Year and Date
  2010-11-24
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] HIV陽性者のメンタルヘルスへのアプローチその2メンタルヘルス問題の「今」を考える:どのように捉え、どうアプローチすることが可能だろうか?～うつと依存症(薬物)を中心に2010
- Author(s)
  松下修三
- Organizer
  第24回日本エイズ学会学術集会・総会
- Place of Presentation
  グランドプリンスホテル高輪ザ・プリンス.東京都
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] 抗HIV-1V3抗体からの逃避過程で挿入されるV2領域の糖鎖が保存されるメカニズム-HIV-1の進化における耐性度と増殖能のバランスに関する考察-2009
- Author(s)
  畑田万紀子、吉村和久、原田惠嘉、松下修三
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  都市センターホテル.東京都
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] エンベロープの進化と中和抗体.シンポジウムHIV細胞侵入とその防御機構2009
- Author(s)
  松下修三
- Organizer
  第23回日本エイズ学会学術集会・総会
- Place of Presentation
  名古屋・名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Polyclonal antibody response against gp120 including antibodies to V3, CD4bs and CD4i epitopes account or broad neutralization2009
- Author(s)
  松下修三
- Organizer
  5th Conference on HIV Pathogenesis, Treatment and Prevention
- Place of Presentation
  Cape Town, South Africa Cape Town Convention Center
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Accumulation of multiple functional mutations in HIV-1 gp120 is involved in the development of neutralization escape under pressure of neutralizing antibody in vitro2009
- Author(s)
  Matsushita, S.
- Organizer
  Kumamoto AIDS Seminar GCOE Joint International Symposium-Satellite Symposium
- Place of Presentation
  Aso Resort Granvilio Hotel. Aso, Kumamoto
- Year and Date
  2009-09-30
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Polyclonal antibody response against gp120 including antibodies to V3, CD4bs and CD4i epitopes account or broad neutralization. 10th Kumamoto AIDS Seminar GCOE Joint International Symposium2009
- Author(s)
  松下修三
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposim
- Place of Presentation
  Kumamoto・Hotel Nikko Kumamoto
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Mechanism of maintaining a glycan-insertion in HIV-1 gp120 V2 region under pressure of a potent neutralizing antibody in vitro2009
- Author(s)
  Hatada, M., Yoshimura, K., Harada, S., Matsushita, S.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto. Kumamoto
- Year and Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Mutations in V4 and C4 regions of the HIV-1 CRF-BC envelope induced by the in vitro selection of Maraviroc Confer cross-resistance to other CCR5 inhibitors2009
- Author(s)
  Yoshimura, K., Harada S., Hatada, M., Matsushita, S.
- Organizer
  16th Conference on Trtroviruses and Opportunistic Infections(CROI 2009)
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] 最近分離した7種の臨床HIV-1株を用いたin vitroラルテグラビル耐性ウイルス誘導2009
- Author(s)
  原田恵嘉, 吉村和久, 松下修三
- Organizer
  第23回日本エイズ学会学術集会・総会
- Place of Presentation
  名古屋国際会議場.愛知県名古屋市
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] A primary R5 isolate undergoes different escape pathway during in vitro selection with low or high concentration of an anti-V3 monoclonal antibody2009
- Author(s)
  Narahara, C., Hatada, M., Harada, S., Yoshimura, K, . Matsushita, S.
- Organizer
  AIDS Vaccine 2009
- Place of Presentation
  The Marriott Rive Gauche Conference Center Paris, France
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] エンベロープの進化と中和抗体.シンポジウムHIV細胞侵入とその防御機構2009
- Author(s)
  松下修三
- Organizer
  第23回に本エイズ学会学術集会・総会
- Place of Presentation
  名古屋国際会議場.愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] HIV-1に対する中和単クローン抗体の治療応用に向けた基礎研究2009
- Author(s)
  松下修三
- Organizer
  第9回日本蛋白質化学学会
- Place of Presentation
  熊本全日空ホテルニュースカイ.熊本市
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Mechanism of maintaining a glycan-insertion in HIV-1 gp120 V2 region under pressure of a potent neutralizing antibody in vitro2009
- Author(s)
  Matsushita, S., Narahara, C., Nishida, Y., Honda, A., Harada, S., Yoshimura, K.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Kumamoto
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] 実験室HIV-1 R5株を用いたin vitro CCR5阻害薬(maraviroc)耐性ウイルス誘導の試み2009
- Author(s)
  石川哲也, 畑田万紀子, 原田恵嘉, 吉村和久, 松下修三
- Organizer
  第23回に本エイズ学会学術集会・総会
- Place of Presentation
  名古屋国際会議場.愛知県名古屋市
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Generation of an integrase inhibitor raltegravir resistant variants using recent primary isolates, X4, R5 and dual/mix HIV-12009
- Author(s)
  Harada, S., Yoshimura, K., Matsushita, S.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Kumamoto
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] HIV-1に対する中和単クローン抗体の治療応用に向けた基礎研究2009
- Author(s)
  松下修三
- Organizer
  第9回日本蛋白質化学学会
- Place of Presentation
  熊本・熊本全日空ホテルニュースカイ
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Impact of V2 mutations for escape from a potent neutralizing anti-V3 monoclonal antibody during in vitro selection of a primary HIV-1 isolate2009
- Author(s)
  Shibata, J., Yoshimura, K., Honda, A., Koito, A., Murakami, T., Matsushita, S.
- Organizer
  7th AIDS Seminar in Kumamoto
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] Polyclonal antibody response against gp120 including antibodies to V3, CD4bs and CD4i epitopes account or broad neutralization2009
- Author(s)
  Matsushita, S., Narahara, C., Morizono, M., Nishida, Y., Honda. Shibata, A., Harada, S., Yoshimura, K, .
- Organizer
  5th Conference on HIV Pathogenesis, Treatment and Prevention
- Place of Presentation
  Cape Town Convensition Center, Cape Town, South Africa
- Year and Date
  2009-07-20
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] In vitro induction of HIV-1 resistant to a CCR5 antagonist maraviroc2009
- Author(s)
  Yoshimura, K., Harada, S., Hatada, M., Matsushita, S.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Kumamoto
- Year and Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] In vitro induction of HIV-1 resistant to a CCR52009
- Author(s)
  Yoshimura, K., Matsushita, S.
- Organizer
  Kumamoto AIDS Seminar GCOE Joint International Symposium-Satellite Symposium
- Place of Presentation
  Aso Resort Granvilio Hotel. Aso, Kumamoto
- Year and Date
  2009-09-30
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] Mutations in gp120 of R5 HIV-1 laboratory isolate induced by the in vitro selection of maraviroc confer highly sensitive to anti-V3 monoclonal antibody2009
- Author(s)
  Ishikawa, T., Yoshimura, K., Hatada, M., Harada, S., Matsushita, S.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Kumamoto
- Year and Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-21591295
[Presentation] The impact of an N-linked glycosylation site insertion in HIV-1 gp120 region to escape from a potent neutralization anti-V3 monoclonal antibody2008
- Author(s)
  Hatada, M., Yoshimura, K, Ishikawa, T., Harada, S., Matsushita, S.
- Organizer
  9^<th> Kumamoto AIDS Seminar
- Place of Presentation
  Aso, Kumamoto
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] CD4 mimic small compoundのin vitro耐性誘導による結合部位の予測2008
- Author(s)
  吉村和久、原田恵嘉、畑田万紀子、増野弘幸、玉村啓和、松下修三
- Organizer
  第22回日本エイズ学会学術集会・総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] Different mutation in HIV-1 gp120 V3-tip regin for escape from a potent neutralizing anti-V3 monoclonal antibody during in vitro selection with low or high concentration of the Mab2008
- Author(s)
  Narahara, C., Yoshimura, K., Hatada, M., Harada, S., Matsushita, S.
- Organizer
  9^<th> Kumamoto AIDS Seminar
- Place of Presentation
  Aso, Kumamoto
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] CD4 mimic small compoundとanti-HIV monoclonal antibodyのウイルス中和における相乗効果2008
- Author(s)
  吉村和久、柴田潤二、畑田万紀子、山田裕子、増野弘幸、玉村啓和、松下修三
- Organizer
  第21回日本エイズ学会学術集会・総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] 中和抗体高感受性R5臨床分離株の抗V3抗体によるin vitro中和逃避ウイルス誘導2008
- Author(s)
  楢原知里、吉村和久、畑田万紀子、原田恵嘉、松下修三
- Organizer
  第22回日本エイズ学会学術集会・総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] 長期間HAART有効症例における残存HIVと組込み部位の関連性2008
- Author(s)
  池田輝政、柴田潤二、吉村和久、小糸厚、松下修三
- Organizer
  第54回日本ウイルス学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] In vitro induction of human immunodeficienby virus type 1 variants resistant to a low-molecular CD4 mimic compound2008
- Author(s)
  Yoshimura, K., Hatada, M., Harada, S., Shibata, J., Masuo, H., Tamamura, H., Matsushita, S.
- Organizer
  9^<th> Kumamoto AIDS Seminar
- Place of Presentation
  Aso, Kumamoto
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] In vitro induction of human immunodeficienby virus type 1 variants resistant to a low-molecular CD4 mimic compound, N-(4-Chlorophenyl)-N'-(2, 2, 6, 6-tetramethylpiperidin-4-yl)-oxalamide (NBD-556)2008
- Author(s)
  Yoshimura, K., Shibata J., Honda, A., Yamada, Y., Nasuo, H., Tamamura, H., Matsushita, S.
- Organizer
  15th Conference on Retroviruses and Opportunistic infections
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] Broad cross-neutralization mediated by combination of anti-V3 and CD4 binding site antibodies in an HIV-1 infected patient with long-term non-progressie disease2008
- Author(s)
  Matsushita, S., Nishida, Y., Shibata J., Honda A., Yoshimura, K
- Organizer
  15th Conference on Retroviruses and Opportunistic infections
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] V2領域のN-glycosylation site挿入が抗V3中和抗体エスケープに及ぼす影響2008
- Author(s)
  畑田万紀子、吉村和久、石川哲也、原田恵嘉、松下修三
- Organizer
  第22回日本エイズ学会学術集会・総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] 長期非進行症例 (LTNP) における交叉中和のメカニズムの研究 I; 中和単クローン抗体の作成と解析2007
- Author(s)
  松下修三
- Organizer
  第21回日本エイズ学会学術集会・総会
- Place of Presentation
  広島県広島市
- Year and Date
  2007-11-28
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] 長期非進行症例(LTNP)における交叉中和のメカニズムの研究I ; 中和単クローン抗体の作成と解析2007
- Author(s)
  松下修三、西田吉辰、柴田潤二、畑田万紀子、吉村和久
- Organizer
  第21回日本エイズ学会学術集会・総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] Development of broadly reactive neutralizing monoclonal antibody KD-247: implications for passive immunotherapy2007
- Author(s)
  Matsushita, S.
- Organizer
  3rd Japan-Germany HIV/AIDS Symposium
- Place of Presentation
  Hiroshima.
- Year and Date
  2007-11-26
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] 長期非進行症例(LTNP)における交叉中和のメカニズムの研究II ; 中和単クローン抗体のsubtype B panelに対する交差中和活性2007
- Author(s)
  西田吉辰、柴田潤二、吉村和久, 松下修三
- Organizer
  第21回日本エイズ学会学術集会・総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] 中和抗体高度抵抗性ウイルスを感受性にする変異はgp120三量体構造に影響を与える2007
- Author(s)
  柴田潤二、吉村和久、松下修三
- Organizer
  第21回日本エイズ学会学術集会・総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] Persistence of proviral DNA and the integration sites of HIV-1 in patients on prolonged and effective HAART2007
- Author(s)
  Matsushita, S.
- Organizer
  4^<th> IAS Conference on HIV Pathogenesis, Treatment and Prevention.
- Place of Presentation
  Sydney,Australia.
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] 強力な抗HIV-1 gp120-V3抗体KD-247に対するHIV-1BaLの中和逃避のメカニズム解析2007
- Author(s)
  畑田万紀子, 吉村和久, 柴田潤二, 松下修三
- Organizer
  第21回日本エイズ学会学術集会・総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] シンポジウム3「より良いHAARTに向けて」-耐性検査の意義とタイミング2006
- Author(s)
  松下修三
- Organizer
  第20回日本エイズ学会学術集会・総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] Resistance Profile of A Novel Broadly Neutralizing Anti-HIV Monoclonal Antibody, KD-247 That Has Favorable Synergism with Anti-CCR5 Inhibitors In Vitro2006
- Author(s)
  Yoshimura, K., Shibata, J., Honda A., Murakami, T., Mitsuya, H., Koito, A.,and and Matsushita, S.
- Organizer
  13th Conference on Retroviruses and Opportunistic Infections
- Place of Presentation
  Denver, USA
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] 抗HIV-1 gp120-V3抗体より逃避したV2領域変異ウイルスの中和抵抗性メカニズムの解析2006
- Author(s)
  柴田潤二、吉村和久、小糸厚、松下修三
- Organizer
  第54回日本ウイルス学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] Recurrent HIV-1 integration at BACH2 locus in resting CD4+T cell populations during effective HAART2006
- Author(s)
  Ikeda, T., Shibata, J., Yoshimura, K., Koito, A., Matsushita, S.
- Organizer
  7th AIDS Seminar in Kumamoto
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] Development of broadly reactive neutralizing monoclonal antibody KD247 : implications for passive immunotherapy2006
- Author(s)
  Matsushita, S., Shibata, J., Honda, A., Murakami, T., Eda, Y., Koito, A., Yoshimura, K.
- Organizer
  AIDS Vaccine 2006 Conference, Amsterdam, the Netherlands
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] A Role of Mutations in Non-V3 Envelope Regions for Escape from a Broad Neutralizing Anti-V3 Monoclonal Antibody, KD-247, during in vitro Selection2006
- Author(s)
  Shibata, J., Yoshimura, K., Honda A., Murakami, T., Koito, A., and Matsushita, S.
- Organizer
  13th Conference on Retroviruses and Opportunistic Infections
- Place of Presentation
  Denver, USA
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] In vitroにおける抗HIV-1中和単クローン抗体とその他の薬剤との相互作用の研究2006
- Author(s)
  吉村和久、柴田潤二、小糸厚、松下修三
- Organizer
  第20回日本エイズ学会学術集会・総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18591119
[Presentation] Mutations in gp41 that confer resistance to fusion inhibitors enhance the neutralization sensitivity to antibodies against both gp41 and gp120.
- Author(s)
  Muntasir, A., Kuwata, T., Ramirez, K., Enomoto, I., Maruta, Y., Tanaka, K., Rahman, K., Nakahara, Y., Egami, Y., Kawanami, Y., Murayama, H., Shimura, K., Matsuoka, M., Matsushita, S.
- Organizer
  15th Kumamoto AIDS Seminar
- Place of Presentation
  グランヴィリオホテル（阿蘇市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Therapeutic application of neutralizing antibodies based on the recent data on complementary and synergistic activities against a wide range of HIV-1 strains.
- Author(s)
  Matsushita, S., Ramirez, K.P., Maruta, Y., Tanaka, K., Muntasir, A., Kuwata, T., Pisupait, J., Murakami, T., Yoshimura, K.
- Organizer
  15th Kumamoto AIDS Seminar.
- Place of Presentation
  ホテル日航熊本（熊本市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Passive transfer of neutralizing monoclonal antibody KD-247 reduces plasma viral load in patients chronically infected with HIV-1：A Phase-1b clinical study of a humanized monoclonal antibody KD-247 (KD-1002)
- Author(s)
  Matsushita, S.
- Organizer
  IAS Towards an HIV Cure Symposium
- Place of Presentation
  The Banquet Hall, Rits Carlton Hotel(Kuala Lumpur, Malaysia)
- Year and Date
  2014-06-29 – 2014-06-30
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Mechanism of post-attachment neutralization of single-chain variable fragment (scFv) from anti-V3 monoclonal antibody against HIV-1.
- Author(s)
  Maruta, Y., Kuwata, T., Tanaka, K., Nakahara,Y., Ramirez, K., Alam, M., Egami, Y., Hirata I., Suwa, Y., Morioka, H., Matsushita, S.
- Organizer
  15th Kumamoto AIDS Seminar.
- Place of Presentation
  グランヴィリオホテル（阿蘇市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Complementary effect of anti-V3, CD4bs and CD4i antibodies accounts for cross-neutralizing and non-neutralizing activities against HIV-1.
- Author(s)
  Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S.
- Organizer
  第28回日本エイズ学会学術集会・総会.
- Place of Presentation
  大阪国際会議場（大阪市）
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] V3エピトープへの交叉反応性をもつ中和抗体の遺伝子組み換えによる小型化の試み
- Author(s)
  江上由華、丸田泰広、田中和樹、Muntasir　A., Ramirez K., 桑田岳夫、松下修三.
- Organizer
  第28回日本エイズ学会学術集会・総会.
- Place of Presentation
  大阪国際会議場（大阪市）
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Evaluation of complementarity and synergy of conventional anti-HIV-1 antibodies derived from a single individual
- Author(s)
  Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka, K., Muntasir, A., Yoshimura, K., Matsushita, S.
- Organizer
  15th Kumamoto AIDS Seminar
- Place of Presentation
  グランヴィリオホテル（阿蘇市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Mechanism of post-attachment neutralization of single-chain variable fragment (scFv) from anti-V3 monoclonal antibody against HIV-1
- Author(s)
  Maruta, Y., Kuwata, T., Tanaka, K., Nakahara,Y., Ramirez, K., Alam, M., Egami, Y., Hirata I., Suwa, Y., Morioka, H., Matsushita, S.
- Organizer
  HIV R4P 2014
- Place of Presentation
  Cape Town International Convention Centre(Cape Town, South Africa)
- Year and Date
  2014-10-28 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Passive transfer of neutralizing monoclonal antibody KD-247 reduces plasma viral load in patientschronically infected with HIV-1: a phase-1b clinical study of a humanized monoclonal antibody KD-247 (KD-1002).
- Author(s)
  Matsushita, S., Yoshimura, K., Maeda, T, Murakami, T. KD-1002 Principal Investigators and The Protocol Team of Quintiles.
- Organizer
  7th IAS Conference on HIV Pathogenesis, Treatment and Prevention
- Place of Presentation
  Kuala Lumpur Convention Centre (Kuala Lumpur, Malaysia)
- Year and Date
  2014-06-30 – 2014-07-03
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Construction of neutralizing antibody fragment against V3 with a broad cross-reactivity.
- Author(s)
  Tanaka K., Kuwata, T., Maruta, Y., Ramirez, K., Muntasir, A., Egami, Y., Enomoto, I., Kawanami, Y., Matsushita, S.
- Organizer
  15th Kumamoto AIDS Seminar
- Place of Presentation
  グランヴィリオホテル（阿蘇市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] 強力な抗SIV中和抗体B404からの逃避メカニズムの解析
- Author(s)
  桑田岳夫、松下修三
- Organizer
  第28回日本エイズ学会学術集会・総会
- Place of Presentation
  大阪国際会議場（大阪府北区）
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Enhanced Neutralization of HIV-1 with Fusion Inhibitor Resistant Mutations. The annual Conference on Retroviruses and Opportunistic Infections (CROI 2015).
- Author(s)
  Muntasir, A., Kuwata, T., Ramirez, K., Maruta, Y., Tanaka K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushita, S.
- Organizer
  The annual Conference on Retroviruses and Opportunistic Infections (CROI 2015).
- Place of Presentation
  the Washington State Convention Center(Seattle, Washington, USA.)
- Year and Date
  2015-02-23 – 2015-02-26
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Therapeutic application of neutralizing antibodies based on the recent data on complementary and synergistic activities against a wide range of HIV-1 strains.
- Author(s)
  Matsushita, S., Ramirez, K.P., Maruta, Y., Tanaka, K., Muntasir, A., Kuwata, T., Pisupait, J., Murakami, T., Yoshimura, K.
- Organizer
  the 17th International Conference on Emerging Infectious Diseases (EID) Emerging Infectious Diseases Meeting
- Place of Presentation
  Building of Humanities and Social Sciences, Academia Sinica(Taipei, Taiwan)
- Year and Date
  2015-01-26 – 2015-01-27
- Data Source
  KAKENHI-PROJECT-24591484
[Presentation] Mutations in gp41 is Critical to Escape from B404, a Broad Neutralizing Antibody Against SIV, Which Recognizes a V3/V4 Conformational Epitope
- Author(s)
  Takeo Kuwata, Kazuhisa Yoshimura, Fan Wu, Ilnour Ourmanov, Vanessa M. Hirsch, Masaru Yokoyama, Hironori Sato and Shuzo Matsushita
- Organizer
  32nd Annual Symposium on Nonhuman Primate Models for AIDS
- Place of Presentation
  The Nines Hotel (Portland, Oregon, USA)
- Year and Date
  2014-11-11 – 2014-11-14
- Data Source
  KAKENHI-PROJECT-26430091

1. 服部俊夫 (30172935)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. UCHIYAMA Takashi (80151900)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. NAGAI Yoshiyuki (20022874)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MITUYA Yoshiaki (20136724)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMAMOTO Naoki (00094053)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KOYANAGI Yoshio (80215417)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. HAYAMI Masanori (40072946)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KUWATA Takeo (70346063)

# of Collaborated Projects: 2 results

# of Collaborated Products: 33 results
9. Sakamoto Maiko (10720196)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
10. 志田壽利 (00144395)

# of Collaborated Projects: 2 results

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11. 庄司省三 (60040317)

# of Collaborated Projects: 2 results

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12. 高橋一郎 (40091045)

# of Collaborated Projects: 2 results

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13. 三隅将吾 (40264311)

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# of Collaborated Products: 10 results
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18. HORI Toshiyuki (70243102)

# of Collaborated Projects: 1 results

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19. IWAKURA Yoichiro (10089120)

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20. BABA Masanori (70181039)

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21. TANAKA Yuetsu (30163588)

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22. FUJII Nobutaka (60109014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. IGARASHI Tatsuhiko (90467431)

# of Collaborated Projects: 1 results

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24. 島田隆 (20125074)

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# of Collaborated Projects: 1 results

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27. 高久洋 (50101267)

# of Collaborated Projects: 1 results

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28. 吉村和久 (60315306)

# of Collaborated Projects: 1 results

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29. 塩田達雄 (00187329)

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36. 宮川寿一 (40347000)

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37. 山之内純 (10423451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
38. 南留美 (80333516)

# of Collaborated Projects: 1 results

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39. NARUMI Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. HARADA Shigeyoshi

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# of Collaborated Products: 4 results
41. HISHIKI Takayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
42. 森岡弘志

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# of Collaborated Products: 1 results
43. 前田洋助

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
44. 俣野哲朗

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45. 村本裕紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 辻耕平

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
47. 上野貴将

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MATSUSHITA SHUZO 松下 修三

MATSUSHITA Shuzo 松下 修三

松下 修三 マツシタ シユウゾウ

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Induction of SARS CoV-2 neutralizing antibodies by anti-idiotype antibodiesPrincipal Investigator

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Induction of HIV neutralizing antibodies by anti-idiotype antibodiesPrincipal Investigator

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Research toward elimination of HIV persistent infected cells remaining under antiretroviral therapy (ART)Principal Investigator

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Development of a panel of neutralizing monoclonal antibodies aiming toward HIV curePrincipal Investigator

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Development of vaccine against HIV/AIDS using a panel of neutralizing monoclonal antibodies.Principal Investigator

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Development of vaccine that induces neutralizing antibodies to HIV-1Principal Investigator

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Development of mimotope vaccine against HIV-1Principal Investigator

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Basic Research for AIDS control A03 ; Prevention and control of AIDSPrincipal Investigator

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Analysis of the interaction between chemokine receptor and V3 region of HIV-gp120 by neutralizing antibodiesPrincipal Investigator

MATSUSHITA SHUZO 松下修三

MATSUSHITA Shuzo 松下修三

松下修三マツシタシユウゾウ