WAKASUGI Hiro 若杉尋

… Alternative Names

若杉尋ワカスギヒロ

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Researcher Number	10112632
Other IDs
Affiliation (based on the past Project Information) *help	2003: 国立がんセンター, 研究所・薬効試験部, 部長 2002 – 2003: 国立がんセンター研究所, 薬効試験部, 部長 2000: 国立がんセンター, 研究所, 部長 1994 – 1996: 国立がんセンター研究所, がん宿主免疫研究室, 室長 1995: National Insti. Cancer Center, がん宿主免疫研, 室長
Review Section/Research Field	Principal Investigator Immunology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator G-CSF / IL-2 / α-GalCer / V_α24^+NKT / 抗腫瘍活性 / ヒト血清・血漿 / Vα24^+NKT細胞 / G-CSF投与 / NKT細胞 / NK細胞 … More / CTL / CD1d非拘束性 / 自己血漿 / 対外増殖法 / ヒトNKT細胞 / CD1d非拘束性細胞障害 / IL-4 / IFN-γ / 自己血清 / ヒトVα24陽性NKT細胞 … More Except Principal Investigator ADF / NMR / チオレドキシン / 抗癌剤耐性 / ラジカルスカベンジャー / Biosensor / Protein interaction / Gene targeting / Higher plants / Morphogenesis / Cre-loxP / Fission yeast / 植物 / 胚形成 / 蛋白高次機能構造 / 遺伝子ターゲティング / RNAプロセシング / バイオモニタリング / DNA再複製 / 細胞周期 / 温度感受性突然変異体 / ATPase / 免疫病 / 免疫系 / バイオセンサー / 分子相互作用 / 遺伝子標的 / 高等植物 / 形態形成 / Cre-IoxP / 分裂酵母 / T細胞刺激補助分子 / レチノイン酸 / 遺伝子治療 / Bリンパ球性白血病 / 骨髄性白血病 / CD40リガンド / 腫瘍マーカー / レドックス / 耐性 / 抗癌剤 / チオレオキシン Less

Analysis of human NKT cells and the development of exvivo expansion methodsPrincipal Investigator
- Principal Investigator
  
  WAKASUGI Hiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  National Cancer Center Research Institute
CD40リガンドを用いたヒト白血病に対する遺伝子治療の研究
- Principal Investigator
  
  加藤和則
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
腫瘍でのADF/チオレドキシンの活性化機構並びに抗癌剤の影響と作用機序の解析
- Principal Investigator
  
  淀井淳司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
腫瘍でのADF/チオレドキシンの活性化機構並びに抗癌剤の影響と作用機序の解析
- Principal Investigator
  
  淀井淳司
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
腫瘍でのADF/チオレドキシンの活性化機構並びに抗癌剤の影響の作用機序の解析
- Principal Investigator
  
  淀井淳司
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University

All 2004 2003 2002

All Journal Article

[Journal Article] Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects.2004
- Author(s)
  Borg C, Terme M, Taieb J, Menard C, Flament C, Robert C, Maruyama K, Wakasugi H, Angevin E, Thielemans K, Le Cesne A, Chung-Scott V, Lazar V, Tchou I, Crepineau F, Lemoine F, Bernard J, Fletcher JA, Turhan A, Blay JY, Spatz A, Emile JF, Heinrich MC, Mecheri S, Tursz T, Zitvogel L.
- Journal Title
  
  J Clin Invest. 114(3)
  
  Pages: 379-388
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] Role Of Natural Killer T Cells In Anti-Tumor Immune Response.2004
- Author(s)
  Yoshinori Ikarashi, Yuji Heike, Atsushi Shimizu, Osamu Imataki, Sachiyo Kanai, Mitsuzi Yoshida, Akira liduka, Takayuki Morikawa, Yoichi Takauel, Hiro Wakasugi.
- Journal Title
  
  Extended Abstracts for the 34nd International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 2004.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] Allogeneic Immune-Mediated Anti-Cancer Effect With Reduced-Intensity Stem Cell Transplantation.2004
- Author(s)
  Yuji Heike, Masahiro Kami, Shinichiro Mori, Ryuji Tanosaki, Shigesaburo Miyakoshi, Shuichi Taniguchi, Hiro Wakasugi, Yoichi Takaue.
- Journal Title
  
  Extended Abstracts for the 34nd International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 2004.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] The mouse natural killer T cell-associated antigen recognaized by U5A2-13 monoclonal antibody is intercellular adhesion molecule-12004
- Author(s)
  Shimizu, A., Sasaki, H., Aoyagi., Yoshida, M., Kato, K., Heike, Y., Ikarashi, Y., Shirakawa, K., Takaue, Y., Miyajima, A., Terada, M., Nagai, H., Wakasugi, H.
- Journal Title
  
  Immunology Letters 92
  
  Pages: 227-235
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] IL-4 Confers NK Stimulatory Capacity to Murine Dendritic Cells : A Signaling Pathway Involving KARAP/DAP12-Triggering Receptor Express on Myeloid Cell 2 Molecules^12004
- Author(s)
  Terme M, Tomasello E, Maruyama K, Crepineau F, Chaput N, FlamentC, Marolleau JP, Angevin E, Wagner EF, Salomon B, Lemonnier FA, Wakasugi H, Colonna M, Vivier E, Zitvogel L.
- Journal Title
  
  J.Immunol. 172(10)
  
  Pages: 5957-5966
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] NK cell activation by Dendritic Cells (DC)require The Formation of a Synapse leading to IL-12 Polarization in DC.2004
- Author(s)
  Borg C, Terme M, Taieb J, Menard C, Flament C, Robert C, Maruyama K, Wakasugi H, Angevin E, Thielemans K, Le Cesne A, Chung-Scott V, Lazar V, Tchou I, Crepineau F, Lemoine F, Bernard J, Fletcher JA, Turhan A, Blay JY, Spatz A, Emile JF, Heinrich MC, Mecheri S, Tursz T, Zitvogel L.
- Journal Title
  
  J Clin Invest. 114(3)
  
  Pages: 379-388
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] CD4^+ CD25^+ T cells responding to serologically defined autoantigens suppress antitumor immune responses.2003
- Author(s)
  Hiroyoshi Nishikawa, Takuma Kato, Koji Tanida, Atsunori Hiasa, Isao Tawara, Hiroaki Ikeda, Yoshinori Ikarashi, Hiro Wakasugi, Mitchell Kronenberg, Toshinori Nakayama, Masaru Taniguchi, Kagemasa Kuribayashi, Lloyd J.Old, Hiroshi Shiku.
- Journal Title
  
  Proc Natl Acad Sci USA 100
  
  Pages: 10902-10906
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] Increased expansion of V_24^+T cells derived from G-CSF mobilized peripheral blood stem cells as compared to peripheral blood mononuclear cells following_-galactosylceramide stimulation.2003
- Author(s)
  Rumiko Asada-Mikami, Yuji Heike, Yukie Harada, Sachiyo Kanai, Yoshinori Ikarashi, Kazunori Kato, Kazuo Shirakawa, Yoichi Takaue, Tatsuo Abe, Hiro Wakasugi.
- Journal Title
  
  Cnacer Science 94
  
  Pages: 383-388
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] U5A2-13, an antigen originally found on mouse NK-like T Cells, is an early inducible cell surface antigen during lymphoid activation.2003
- Author(s)
  Kazunori Kato, Yoshinori Ikarashi, Toshiaki Sugahara, Atsushi Yasumoto, David Sancho, Mitsuzi Yoshida, Yoichi Takaue, Yoshiro Kobayashi, Francisco Sanchez-Madrid, Hiro Wakasugi.
- Journal Title
  
  Cellular Immunology 221
  
  Pages: 27-36
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291
[Journal Article] U1B3.3 monoclonal antibody recognizes a precursor of NK1.1^+ cytotoxic T cells generated by interleukin-2.2002
- Author(s)
  Ikarashi Y, Kato K, Yoshida M, Wakasugi H.
- Journal Title
  
  Proc.Japan Acad. 78
  
  Pages: 91-95
- NAID
  130000907847
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570291

1. 淀井淳司 (80108993)

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WAKASUGI Hiro 若杉 尋

若杉 尋 ワカスギ ヒロ

Research Projects

Research Products

Co-Researchers

Analysis of human NKT cells and the development of exvivo expansion methodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CD40リガンドを用いたヒト白血病に対する遺伝子治療の研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腫瘍でのADF/チオレドキシンの活性化機構並びに抗癌剤の影響と作用機序の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

腫瘍でのADF/チオレドキシンの活性化機構並びに抗癌剤の影響と作用機序の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

腫瘍でのADF/チオレドキシンの活性化機構並びに抗癌剤の影響の作用機序の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Regulation of Gene Expression

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Role Of Natural Killer T Cells In Anti-Tumor Immune Response.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Allogeneic Immune-Mediated Anti-Cancer Effect With Reduced-Intensity Stem Cell Transplantation.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] The mouse natural killer T cell-associated antigen recognaized by U5A2-13 monoclonal antibody is intercellular adhesion molecule-12004

Author(s)

Journal Title

Description

Data Source

[Journal Article] IL-4 Confers NK Stimulatory Capacity to Murine Dendritic Cells : A Signaling Pathway Involving KARAP/DAP12-Triggering Receptor Express on Myeloid Cell 2 Molecules^12004

Author(s)

Journal Title

Description

Data Source

[Journal Article] NK cell activation by Dendritic Cells (DC)require The Formation of a Synapse leading to IL-12 Polarization in DC.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] CD4^+ CD25^+ T cells responding to serologically defined autoantigens suppress antitumor immune responses.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Increased expansion of V_24^+T cells derived from G-CSF mobilized peripheral blood stem cells as compared to peripheral blood mononuclear cells following_-galactosylceramide stimulation.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] U5A2-13, an antigen originally found on mouse NK-like T Cells, is an early inducible cell surface antigen during lymphoid activation.2003

Author(s)

Journal Title

WAKASUGI Hiro 若杉尋

若杉尋ワカスギヒロ