Takei Nobuyuki 武井延之

… Alternative Names

TAKEI Nobuyuki 武井延之

武井延之タケイノブユキ

TAKEI N. 武井延之

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Researcher Number	70221372
Other IDs
External Links
Affiliation (Current)	2025: 新潟大学, 脳研究所, 非常勤講師
Affiliation (based on the past Project Information) *help	2010 – 2024: 新潟大学, 脳研究所, 准教授 2016: 新潟大学, 脳研究所, 准教教 1999 – 2007: 新潟大学, 脳研究所, 助教授 1993: 京都工芸繊維大学, 繊維学部, 助手 1990: 国立精神, 神経センター・神経研究所代謝研究部, 研究員 1990: Natl. Inst. Neurosci., Res. Scientist, 神経センター神経研究所・代謝研究部, 研究員
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Biological Sciences / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related / Basic Section 57060:Surgical dentistry-related / Neurophysiology / General neuroscience / Biological Sciences / Basic Section 48010:Anatomy-related … More / Integrative animal science / Surgical dentistry / Cerebral neurosurgery / Nerve anatomy/Neuropathology / General anatomy (including Histology/Embryology) / Biological Sciences Less
Keywords	Principal Investigator BDNF / mTOR / 蛋白合成 / 翻訳調節 / ニューロン / eEF2 / LTP / グルタミン酸 / 神経細胞 / 細胞サイズ … More / eIF2a / eEF2キナーゼ / 翻訳伸展 / p70S6K / 4EBP / 局所的蛋白合成 / 空間学習 / 神経栄養因子 / 神経活動 / 脳・神経 / 細胞・組織 / 神経科学 / 神経発達 / iPS / neural stem cell / 細部サイズ / デコイ / シグナル伝達 / 脳形成異常 / 神経分化 / 神経幹細胞 / spatial learning / neural plasticity / local protein synthesis / translational control / neuron / カイニン酸 / 可塑性 / PDZ PROTEINS / GLUTAMATE / SYNAPTIC PLASTICITY / TRANSMITTER RELEASE / NEUROTROPHIN / 初代培養 / 小脳顆粒細胞 / アスパラギン酸 / グルタミン酸受容体 / PDZ蛋白 / シナプス可塑性 / 神経伝達物質放出 / ニューロトロフィン / FCD / 限局性皮質形成異常 / 脂質合成 / AMPK / eIF2Bε / GSK3b / Wnt3a / 局所的翻訳 / eIF2Be / 成長円錐 / 局所翻訳 / 細胞内情報伝達 / 海馬 / 翻訳因子 / シナプス / Bad / Bcl-X / 大脳皮質ニューロン / DNAアレイ / アポトーシス / PACAP … More Except Principal Investigator 神経栄養因子 / モデル動物 / 統合失調症 / 脳発達 / ドパミン / 中脳ドパミン神経 / セロトニン / 発症機序 / シロリムス / 口内炎 / mTOR阻害剤 / 原子間力顕微鏡 / 成長円錐 / 神経発達 / 上皮成長因子 / 精神疾患 / サイトカイン / Eph/Ephrin / 軸索伸長 / 回路改変 / コネクトーム / 軸索ガイダンス分子 / 神経回路 / 炎症 / 口腔粘膜重層培養 / 口腔粘膜培養 / 細胞間接着因子 / 口腔粘膜細胞 / シロリムス口内炎 / 次世代シークエンサー / 可塑性 / ＲＮＡ‐ＳＥＱ / ユニット解析 / 自発発火 / ユニット記録 / 神経活動 / iPS細胞 / カリウムチャンネル / 黒質 / GDNF / RNA-SEQ / 自律発火 / 依存薬物 / 認知行動異常 / 死後脳 / 非定型抗精神病薬 / ＯＦＦ反応 / 聴覚機能 / 脳内炎症 / 動物モデル / 発声 / ＧＤＮＦ / ＥＧＦ / 脳波 / ニューレグリン / 幻聴 / チュブリン / アクチンフィラメント / 細胞骨格 / 局所的蛋白合成 / 幹細胞 / HP / 神経幹細胞 / 低温耐性 / グリア細胞 / neurosphere / stem cell / 繁殖 / 発情鳴き / 交配実験 / 神経系幹細胞 / 培養 / シマリス / 冬眠 / リンパ脈管筋腫症 / ヒト口腔粘膜上皮細胞培養 / 有害事象 / 口腔粘膜細胞培養 / ウイルスベクター / 脳分子プロファイル / 脳画像データベース / ブレインバンク / 技術開発支援 / 研究リソース支援 / 若手研究者育成支援 / 技術開発 / 研究リソース / 研究集会 / 研究支援 / 脳科学 / Dopamine / Cultured cell / Parkinson's disease / Transplantation / L-DOPA / transfection / cDNA / Tyrosine hydroxylase / ド-パミン / チロジン水酸化酵素 / パ-キンソン病 / LーDOPA / 脳内移植 / 培養細胞 / 遺伝子導入 / チロシン水酸化酵素 / 神経病理学 / 外科病理 / 体細胞変異 / 皮質異形成 / 脳神経疾患 / てんかん / 脊髄後根神経節細胞 / 脳由来神経栄養因子 / 脳・神経 / 神経科学 / 遣伝子 / 細胞・組織 / 蛋白質 / 脳神経 / 脳栄養因子 / ストレス / 認知行動 / 栄養因子 / 電子顕微鏡 / Caイオノフォア / bFGF / ニューロン / アポトーシス Less

炎症シグナルによる皮質神経回路形成の攪乱とリモデリング
- Principal Investigator
  
  那波宏之
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Wakayama Medical University
口腔粘膜重層培養系を用いたmTOR阻害剤による口内炎発症機序の解明
- Principal Investigator
  
  北村信隆
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Niigata University
Analysis of local protein synthesis in growth cones in relation to dynamics of cytoskeleton
- Principal Investigator
  
  Hoshi Osamu
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Tokyo Medical and Dental University
Mechanisms of cell size control during normal and abnormal neural developmentPrincipal Investigator
- Principal Investigator
  
  Nobuyuki Takei
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
Establishment of culture system of chipmunk neural stem cell for elucidating function of hibernation-specific protein (HP)
- Principal Investigator
  
  sekiima tsuneo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Integrative animal science
- Research Institution
  Niigata University
Mechanism of mTOR inhibitor-associated stomatitis
- Principal Investigator
  
  Kitamura Nobutaka
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Niigata University
Regulation of neuronal cell size control in normal and disease conditionPrincipal Investigator
- Principal Investigator
  
  Takei Nobuyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
Pathogenesis of focal cortical dysplasia: possible mechanistic implification of somatic mutations
- Principal Investigator
  
  KAKITA Akiyoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
External and Internal Factors Regulating Inputs/Output Development of Midbrain Dopaminergic Neurons
- Principal Investigator
  
  Nawa Hiroyuki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Niigata University
Analysis of the dynamics of the growth cones by atomic force microscopy
- Principal Investigator
  
  HOSHI Osamu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Tokyo Medical and Dental University
Cytokine-Induced Neuropathologic Endophenotypes of Psychiatric Diseases
- Principal Investigator
  
  Nawa Hiroyuki
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Niigata University
Molecular mechanisms underlying axonal local protein synthesis in neuronsPrincipal Investigator
- Principal Investigator
  
  TAKEI Nobuyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
Comprehensive Brain Science Network
- Principal Investigator
  
  Kimura Minoru
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Center for Novel Science Initatives, National Institutes of Natural Sciences
PrecursorBDNFによるシナプス退縮のメカニズムとその生理的役割
- Principal Investigator
  
  小島正己
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Advanced Industrial Science and Technology
局所的mRNA翻訳マシナリーの活性化と脳高次機能Principal Investigator
- Principal Investigator
  
  武井延之
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Niigata University
刺激に応答したmRNA翻訳マシナリーの神経突起への移動と活性化機構Principal Investigator
- Principal Investigator
  
  武井延之
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Niigata University
Studies on the activity-dependent translational control in neuronsPrincipal Investigator
- Principal Investigator
  
  TAKEI Nobuyuki
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
脳内サイトカインによる中枢神経機能の制御メカニズム:分子から精神活動へ
- Principal Investigator
  
  Nawa Hiroyuki
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Niigata University
PACAPによる神経細胞死抑制においてその下流で働く分子の同定Principal Investigator
- Principal Investigator
  
  武井延之
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Niigata University
Effects of neurotrophins on the regulation of synaptic molecules and on the synaptic functionsPrincipal Investigator
- Principal Investigator
  
  TAKEI Nobuyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  NIIGATA UNIVERSITY
中枢神経細胞のアポトーシスに対する神経栄養因子の作用の形態学的、生化学的研究。
- Principal Investigator
  
  遠藤泰久
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Institute of Technology
Transfection of Tyrosine Hydroxylase cDNA into Cultured Cells : application for Intracerebral Grafting.
- Principal Investigator
  
  KOHSAKA S.
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  National Institute of Neuroscience

[Book] サイトカイン・増殖因子キーワード事典2015
- Author(s)
  武井延之（分担）　（宮園浩平、秋山徹、宮島篤、宮澤恵二編集）
- Total Pages
  420
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25430064
[Book] 脳神経科学イラストレイテッド第三版2013
- Author(s)
  武井延之
- Total Pages
  8
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25430064
[Book] 神経細胞特異的翻訳調節機構2012
- Author(s)
  武井延之監修
- Total Pages
  31
- Data Source
  KAKENHI-PROJECT-22500329
[Journal Article] mTORC1 is involved in DGKb-induced neurite outgrowth and spinogenesis2020
- Author(s)
  Nakai H, Tsumagari R, Nakashima A, Kikkawa U, Ueda S, Yamanoue M, Saito N, Takei N, Shirai Y
- Journal Title
  
  Neurochem. Int.
  
  Volume: 134 Pages: 104645-104645
- DOI
  10.1016/j.neuint.2019.104645
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07053, KAKENHI-PROJECT-17K01847
[Journal Article] Clozapine-dependent inhibition of EGF/neuregulin receptor (ErbB) kinases2019
- Author(s)
  Kobayashi Yutaro、Iwakura Yuriko、Sotoyama Hidekazu、Kitayama Eiko、Takei Nobuyuki、Someya Toshiyuki、Nawa Hiroyuki
- Journal Title
  
  Translational Psychiatry
  
  Volume: 9 Issue: 1 Pages: 181-181
- DOI
  10.1038/s41398-019-0519-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05429, KAKENHI-PROJECT-16K07053
[Journal Article] AMPK activation, eEF2 inactivation, and reduced protein synthesis in the cerebral cortex of hibernating chipmunks2019
- Author(s)
  Yamada S, Kamata T, Nawa H, Sekijima T and Takei N
- Journal Title
  
  Sci. Rep.
  
  Volume: 9 Issue: 1
- DOI
  10.1038/s41598-019-48172-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07053
[Journal Article] Characterization of Functional Primary Cilia in Human Induced Pluripotent Stem Cell-Derived Neurons2019
- Author(s)
  Miki Daisuke、Kobayashi Yuki、Okada Tomoya、Miyamoto Tatuso、Takei Nobuyuki、Sekino Yuko、Koganezawa Noriko、Shirao Tomoaki、Saito Yumiko
- Journal Title
  
  Neurochemical Research
  
  Volume: 印刷中 Issue: 7 Pages: 1736-1744
- DOI
  10.1007/s11064-019-02806-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07053, KAKENHI-PROJECT-19K06739, KAKENHI-PUBLICLY-18H04979, KAKENHI-PROJECT-18H02624, KAKENHI-PROJECT-18K14742
[Journal Article] BDNF reduces eEF2 phosphorylation and enhances novel protein synthesis in growth cones of dorsal root ganglia neurons.2018
- Author(s)
  Hoshi O, Sugizaki A, Cho Y and Takei N
- Journal Title
  
  Neurochem. Res.
  
  Volume: 印刷中 Issue: 6 Pages: 1242-1249
- DOI
  10.1007/s11064-018-2541-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07053
[Journal Article] Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia2018
- Author(s)
  Yukawa、Iwakura、Takei、Saito、Watanabe、Toyooka、Igarashi、Niizato、Oshima、Kunii、Yabe、Matsumoto、Wada、Hino、Iritanii、Niwa、Takeuchi、Takahashi、Kakita、Someya、Nawa
- Journal Title
  
  Psychiatry Research
  
  Volume: 270 Pages: 940-946
- DOI
  10.1016/j.psychres.2018.10.062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07053, KAKENHI-PROJECT-17K10294, KAKENHI-PROJECT-18K06460, KAKENHI-PUBLICLY-18H04670, KAKENHI-ORGANIZER-18H05428, KAKENHI-PROJECT-16K15554, KAKENHI-PROJECT-26293261, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277
[Journal Article] Epidermal growth factor signals attenuate phenotypic and functional development of neocortical GABAergic neurons.2017
- Author(s)
  3)Namba H, Nagano T, Jodo E, Eifuku S, Horie M, Takebayashi H, Iwakura Y, Sotoyama H, Takei N, Nawa H
- Journal Title
  
  J. Neurochem.
  
  Volume: 142 Issue: 6 Pages: 886-900
- DOI
  10.1111/jnc.14097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07053, KAKENHI-PROJECT-15K08173
[Journal Article] Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor2017
- Author(s)
  Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H
- Journal Title
  
  Neuroscience Letters
  
  Volume: 654 Pages: 99-106
- DOI
  10.1016/j.neulet.2017.06.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07052, KAKENHI-PROJECT-16K07053, KAKENHI-PROJECT-17K19527, KAKENHI-PUBLICLY-16H01606, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H03550
[Journal Article] Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation2017
- Author(s)
  Furukawa, K. Fuse, I. Iwakura, Y. Sotoyama, H. Hanyu, O. Nawa, H. Sone, H. Takei, N.
- Journal Title
  
  Cardiovascular diabetology
  
  Volume: 16 Issue: 1 Pages: 20-20
- DOI
  10.1186/s12933-017-0505-y
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350885, KAKENHI-PROJECT-16K07053, KAKENHI-PROJECT-15H05787
[Journal Article] Glutamate-Dependent Ectodomain Shedding of Neuregulin-1 Type II Precursors in Rat Forebrain Neurons.2017
- Author(s)
  1)Iwakura Y, Wang R, Inamura N, Araki K, Higashiyama S, Takei N, Nawa N
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 3 Pages: e0174780-e0174780
- DOI
  10.1371/journal.pone.0174780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07053, KAKENHI-PROJECT-16K15221
[Journal Article] PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a2016
- Author(s)
  Yamaoka M, Ando T, Terabayashi T, Okamoto M, Takei M, Nishioka T, Kaibuchi K, Matsunaga K, Ishizaki R, Izumi T, Niki I, Ishizaki T, Kimura T
- Journal Title
  
  Journal of Cell Science
  
  Volume: 129 Issue: 3 Pages: 637-649
- DOI
  10.1242/jcs.180141
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461342, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-26221302, KAKENHI-PROJECT-25430109, KAKENHI-PROJECT-24390068, KAKENHI-PROJECT-16K07119
[Journal Article] Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb2015
- Author(s)
  Nakashima M, Saitsu H, Takei N, Tohyama J, Kato M, Kitaura H, Shiina M, Shirozu H, Masuda H, Watanabe K, Ohba C, Tsurusaki Y, Miyake N, Zheng Y, Sato T, Takebayashi H, Ogata K, Kameyama S, Kakita A, Matsumoto N
- Journal Title
  
  Ann. Neurol.
  
  Volume: 78 Issue: 3 Pages: 375-386
- DOI
  10.1002/ana.24444
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06736, KAKENHI-PROJECT-15K06751, KAKENHI-PROJECT-15K10367, KAKENHI-PROJECT-26330331, KAKENHI-PROJECT-15K19660, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118005, KAKENHI-PLANNED-24118007, KAKENHI-PROJECT-25250008, KAKENHI-PROJECT-25430064, KAKENHI-PROJECT-25293085, KAKENHI-PROJECT-25293235
[Journal Article] mTOR signaling and its roles in normal and abnormal brain development.2014
- Author(s)
  Takei N and Nawa H.
- Journal Title
  
  Front Mol Neurosci.
  
  Volume: 7 Pages: 28-28
- DOI
  10.3389/fnmol.2014.00028
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430064, KAKENHI-PROJECT-26350885
[Journal Article] mTOR signaling and its roles in normal and abnormal brain development2014
- Author(s)
  Takei N, Nawa H
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24116010
[Journal Article] A possible link between BDNF and mTOR in control of food intake.2014
- Author(s)
  Takei N, Furukawa K, Hanyu O, Sone H, NawaH
- Journal Title
  
  Front. Psychol
  
  Volume: 5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430064
[Journal Article] Neuropathologic implication of peripheral neuregulin-1 and EGF signals in dopaminergic dysfunction and behavioral deficits relevant to schizophrenia: their target cells and time window.2014
- Author(s)
  Nawa H, Sotoyama H, Iwakura Y, Takei N, Namba H.
- Journal Title
  
  Biomed Res Int.
  
  Volume: n/a Pages: 697935-697935
- DOI
  10.1155/2014/697935
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24116010, KAKENHI-PROJECT-25430064
[Journal Article] A possible link between BDNF and mTOR in control of food intake.2014
- Author(s)
  Takei N, Furukawa K, Hanyu O, Sone H, Nawa H.
- Journal Title
  
  Front Psychol
  
  Volume: 5 Pages: 1093-1093
- DOI
  10.3389/fpsyg.2014.01093
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24116010, KAKENHI-PROJECT-26350885
[Journal Article] AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons.2013
- Author(s)
  Ishizuka Y, Kakiya N, Witters LA, Oshiro N, Shirao T, Nawa H, Takei N.
- Journal Title
  
  J Neurochem.
  
  Volume: 127 Issue: 1 Pages: 66-77
- DOI
  10.1111/jnc.12362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430064
[Journal Article] ErbB2 dephosphorylation and anti-proliferative effects of neuregulin-1 in ErbB2-overexpressing cell lines; re-evaluation of their low-affinity interaction.2013
- Author(s)
  Wang, R., Iwakura, Y., Araki, K., Keino-Masu, K., Masu, M., Wang, X., Takei, N., Higashiyama, S. and Nawa, H.
- Journal Title
  
  Scientific reports
  
  Volume: 3 Issue: 1 Pages: 1402-1402
- DOI
  10.1038/srep01402
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22123006, KAKENHI-PROJECT-22500284, KAKENHI-PUBLICLY-24110502, KAKENHI-PROJECT-25293065, KAKENHI-PROJECT-25430064, KAKENHI-PUBLICLY-23112513, KAKENHI-PLANNED-24116010
[Journal Article] Cell-surface expression of themajor Aβdegrading enzyme, neprilysin,depends on phosphorylation by MEK anddephosphorylation by protein phosphatase1a2012
- Author(s)
  Kakiya N, Saito T, Nilsson P, Matsuba Y,Tsubuki S, Takei N, Nawa H, Saido TC
- Journal Title
  
  J Biol Chem
  
  Volume: 287(35) Pages: 29362-72
- Data Source
  KAKENHI-PROJECT-22500329
[Journal Article] 神経細胞特異的翻訳調節機構「基礎の基礎」2012
- Author(s)
  武井延之
- Journal Title
  
  細胞工学
  
  Volume: 31 Pages: 642-645
- Data Source
  KAKENHI-PROJECT-22500329
[Journal Article] Interactions between subcorticalheterotopia and overlying hippocampus mediated by NMDA receptors in humanbrain slices2012
- Author(s)
  Kitaura H, Oishi M, Takei N, Fu YJ, Hiraishi T, Fukuda M, Takahashi H,Shibuki K, Fujii Y, and Kakita A
- Journal Title
  
  Epilepsia Jul
  
  Volume: 53(7)
- Data Source
  KAKENHI-PROJECT-22500329
[Journal Article] 神経細胞特異的翻訳調節機構「翻訳調節と脳高次機能」2012
- Author(s)
  武井延之
- Journal Title
  
  細胞工学
  
  Volume: 31 Pages: 687-691
- Data Source
  KAKENHI-PROJECT-22500329
[Journal Article] Dopamine D1-like Receptor-dependent Ectodomain Shedding and Release of Epidermal Growth Factor in Developing Striatal Neurons: (Part2) Target-Derived Neurotrophic Signaling2011
- Author(s)
  Iwakura Y., Wang, R., Abe, Y., Piao, Y., Shishido,Y., Higashiyama, S., Takei, N.and Nawa, H
- Journal Title
  
  J Neurochem
  
  Volume: 118 Pages: 57-68
- Data Source
  KAKENHI-PROJECT-22500329
[Journal Article] Protein Production of an Active Neurotrophic Factor, Neuregulin-1; Qualitative Comparison of In Vitro Translation Systems2011
- Author(s)
  Wang R, Iwakura Y, Araki K, Sotoyama H, Takei N and Nawa H
- Journal Title
  
  Neurosci Lett
  
  Volume: 497 Pages: 90-93
- Data Source
  KAKENHI-PROJECT-22500329
[Journal Article] Qualitative and Quantitative Re-evaluation of Epidermal Growth Factor-ErbB1 Action on Developing Midbrain Dopamine Neurons in vivo nd in vitro; (Part 1) Target-Derived Neurotrophic Signaling2011
- Author(s)
  wakura, Y., Zheng, Y., Abe, Y., Piao, Y., Yokomaku, D., Wang, R., Takei, N. and Nawa, H
- Journal Title
  
  J Neurochem
  
  Volume: 118 Pages: 45-46
- Data Source
  KAKENHI-PROJECT-22500329
[Journal Article] ctivation of mammalian target of rapamycin signaling in spatial learning2010
- Author(s)
  Qi, S., Mizuno, M., Yonezawa, K., Nawa, H. and Takei, N
- Journal Title
  
  Neurosci. Res
  
  Volume: 68 Pages: 88-93
- Data Source
  KAKENHI-PROJECT-22500329
[Journal Article] Downregulation of NF-kB signaling by N-terminal mutant huntingtin proteins induces oxdative stress and cell death2010
- Author(s)
  Reijonen, S., Kukkonen, J.P., Kairisalo, M., Takei, N., Lindholm, D. and Korhonen, L
- Journal Title
  
  Cell Mol. Life Sci
  
  Volume: 67 Pages: 1929-194
- Data Source
  KAKENHI-PROJECT-22500329
[Journal Article] 翻訳調節と脳高次機能2006
- Author(s)
  武井延之
- Journal Title
  
  蛋白質核酸酵素(別冊「RNA と生命」)
  
  Pages: 2617-2623
- Data Source
  KAKENHI-PROJECT-17026012
[Journal Article] シナプスにおける局所的翻訳調節機構2006
- Author(s)
  武井延之
- Journal Title
  
  生化学 78
  
  Pages: 939-948
- NAID
  10018334989
- Data Source
  KAKENHI-PROJECT-17026012
[Journal Article] Enhancement of translation elongation in neurons by brain-derived neurotrophic factor : Implications for mammalian target of rapamycin signaling.2005
- Author(s)
  Inamura, N., Nawa, H., Takei, N.
- Journal Title
  
  J.Neurochem. 95
  
  Pages: 1438-1445
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300122
[Journal Article] 海馬における翻訳因子の発現とその発達変化2005
- Author(s)
  武井延之
- Journal Title
  
  生体の科学 56
  
  Pages: 262-265
- Data Source
  KAKENHI-PROJECT-17026012
[Journal Article] 海馬における翻訳因子の発現とその発達変化2005
- Author(s)
  武井延之
- Journal Title
  
  生体の科学 56
  
  Pages: 262-265
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300122
[Journal Article] ニューロトロフィンによる脳機能の調節--細胞応答から行動変容まで--2004
- Author(s)
  武井延之
- Journal Title
  
  生化学 76
  
  Pages: 111-120
- NAID
  10012684913
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300122
[Journal Article] Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites.2004
- Author(s)
  Takei, N.
- Journal Title
  
  J.Neurosci. 24
  
  Pages: 9760-9769
- Data Source
  KAKENHI-PROJECT-15300122
[Journal Article] Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites2004
- Author(s)
  Takei, N., Inamura, N., Kawamura, M., Namba, H., Hara, K., Yonezawa, K., Nawa, H.
- Journal Title
  
  J.Neurosci. 24
  
  Pages: 9760-9769
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300122
[Journal Article] Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites2004
- Author(s)
  Takei, N.
- Journal Title
  
  J.Neurosci. 24
  
  Pages: 9760-9769
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300122
[Journal Article] Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites.2004
- Author(s)
  Takei N, 他6名
- Journal Title
  
  J Neurosci 24(44)
  
  Pages: 9760-9769
- Data Source
  KAKENHI-PROJECT-13GS0014
[Journal Article] Modulation of brain function by neurotrophins2004
- Author(s)
  Takei N, Nawa H.
- Journal Title
  
  生化学 111(2)
  
  Pages: 12-12
- NAID
  10012684913
- Data Source
  KAKENHI-PROJECT-13GS0014
[Journal Article] Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampus.2003
- Author(s)
  Inamura, N., Nawa, H., Takei, N.
- Journal Title
  
  Neurosci.Lett. 346
  
  Pages: 117-119
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300122
[Journal Article] Phosphatidylinositol 3-kinase : a molecule mediating BDNF-dependent spatial memory formation.2003
- Author(s)
  Mizuno, M., Yamada, K., Takei, N., Tran, M.H., He, J., Nakajima, A., Nawa, H., Nabeshima, T.
- Journal Title
  
  Mol.Psychiatry. 8
  
  Pages: 217-224
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300122
[Journal Article] Differential Distributions of Translation Initiation, Elongation and Release Factors in Rat Hippocampus.2003
- Author(s)
  Inamura, N., Hoshino, S., Uchiumi, T., Nawa, H., Takei, N.
- Journal Title
  
  Mol.Brain Res. 111
  
  Pages: 165-174
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300122
[Presentation] Changes in the relationship between ribosomal protein S6 and actin during local protein synthesis in growth cones2022
- Author(s)
  Osamu Hoshi, Nobuyuki Takei
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-18K06818
[Presentation] シロリムスによる口内炎発症機序の解明2020
- Author(s)
  北村信隆、伊藤祐子、山本陽香、大橋瑠子、泉健次、武井延之、中田光
- Organizer
  第5回LAM研究会
- Data Source
  KAKENHI-PROJECT-19K10307
[Presentation] シロリムス口内炎の発生機序に関する研究2019
- Author(s)
  中田光、山本陽香、伊藤祐子、北村信隆、武井延之
- Organizer
  第１８回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-16K07053
[Presentation] EGFによる神経の軸索伸長とEphシグナルへの干渉2019
- Author(s)
  小林雄太朗、横幕大作，岩倉百合子，北山栄子，那波宏之，武井延之
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-16K07053
[Presentation] 細胞膜剥離法によるラット脊髄後根神経節細胞の成長円錐の形態解析2019
- Author(s)
  星治　武井延之
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-16K07053
[Presentation] 神経細胞一次繊毛局在型GPCRを介するシグナルは繊毛の長さを調節する2019
- Author(s)
  三木大輔, 小林勇喜, 河渕省吾, 宮本達雄, 小金澤紀子, 武井延之, 関野祐子, 白尾智明, 斎藤祐見子
- Organizer
  第92回日本生化学会
- Data Source
  KAKENHI-PROJECT-16K07053
[Presentation] シロリムス口内炎の発症機序に関する研究2018
- Author(s)
  中田光、山本陽香、伊藤裕子、北村信隆、武井延之
- Organizer
  第3回LAM研究会
- Data Source
  KAKENHI-PROJECT-15K11309
[Presentation] ヒトiPSC細胞由来神経細胞における非シナプスマーカー一次繊毛の検出2018
- Author(s)
  三木大輔、小林勇喜、宮本達雄、小金澤紀子、武井延之、関野祐子、白尾智明、斎藤祐見子
- Organizer
  第40回日本生物学的精神医学会／第61回日本神経化学会合同大会
- Data Source
  KAKENHI-PROJECT-16K07053
[Presentation] 神経栄養因子による神経細胞成熟制御2018
- Author(s)
  武井　延之、金村　米博、那波　宏之
- Organizer
  第40回日本生物学的精神医学会／第61回日本神経化学会合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07053
[Presentation] 低温オンチップインキュベーションシステムの開発2018
- Author(s)
  関口知央, 武井延之, 二井信行
- Organizer
  生体医工学会シンポジウム2018
- Data Source
  KAKENHI-PROJECT-16K07053
[Presentation] シマリス神経幹細胞の維持と分化2017
- Author(s)
  武井延之
- Organizer
  第1回冬眠休眠研究会
- Data Source
  KAKENHI-PROJECT-16K15060
[Presentation] Anticancer activity of antipsychotics on brain tumors2017
- Author(s)
  Yutaro Kobayashi, Kohtaro Irie, Ayana Kawase, Nobuyuki Takei, Hiroyuki Nawa
- Organizer
  7th International Society of Radiation Neurobiology Meeting
- Place of Presentation
  ホテル双葉（新潟県南魚沼郡湯沢町）
- Year and Date
  2017-02-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07053
[Presentation] レスベラトロールによるAMPK-mTORシグナルを介した抑制による脳腫瘍細胞増殖制御2017
- Author(s)
  川瀬彩奈、那波宏之、武井延之
- Organizer
  第60回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-16K07053
[Presentation] Epidermal growth factor downregulates presynaptic maturation and suppresses synapse formation in vitro and in vivo.2016
- Author(s)
  Takei N, Yokomaku D, Ushiki D and Nawa H
- Organizer
  7th ISN Special Conference, Synaptic function and dysfunction in brain diseases
- Place of Presentation
  Coimbra, Portugal
- Year and Date
  2016-06-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07053
[Presentation] 冬眠期のシマリス神経細胞におけるAMPKを上流とした翻訳制御2016
- Author(s)
  山田新太郎、関島恒夫、那波宏之、武井延之
- Organizer
  第59回日本神経化学会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-16K07053
[Presentation] 冬眠期のシマリス神経細胞におけるAMPKを上流とした翻訳の抑制2016
- Author(s)
  山田新太郎、関島恒夫、那波宏之、武井延之
- Organizer
  第59回日本神経化学会大会
- Place of Presentation
  福岡国際会議場（福岡県福岡市博多区石城町2-1）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-16K15060
[Presentation] EGF downregulates presynaptic maturation and suppresses synapse formation in vitro and in vivo2015
- Author(s)
  Takei N, Yokomaku D, Ushiki T, Nawa H
- Organizer
  25th ISN Meeting
- Place of Presentation
  Cairns, Australia
- Year and Date
  2015-08-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430064
[Presentation] mTORシグナル系と脳形成異常2015
- Author(s)
  武井延之
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25430064
[Presentation] mTOR mediates neuronal maturation and cell size control.2014
- Author(s)
  Nobuyuki Takei
- Organizer
  ISN satellite symposium on “ Key molecules for neuronal maturation”
- Place of Presentation
  Yayoi Auditorium, The University of Tokyo, Tokyo
- Year and Date
  2014-09-23
- Invited
- Data Source
  KAKENHI-PROJECT-25430064
[Presentation] Structure of growth cones of rat dorsal root ganglion neurons observed by atomic force microscopy2013
- Author(s)
  Osamu Hoshi, Yuichiro Cho, Nobuyuki Takei
- Organizer
  XXIIIInternational Symposium on Morphological Science
- Place of Presentation
  Niigata, Japan
- Data Source
  KAKENHI-PROJECT-24590248
[Presentation] ラット脊髄後根神経節細胞の成長円錐の神経栄養因子による構造変化2013
- Author(s)
  星　治、長　雄一郎、武井延之
- Organizer
  日本解剖学会総会・全国学術集会
- Place of Presentation
  サンポートホール高松・かがわ国際会議場
- Data Source
  KAKENHI-PROJECT-24590248
[Presentation] 冬眠時シマリス脳におけるAMPK を介した翻訳抑制機構2013
- Author(s)
  山田新太郎,近藤宣昭,那波宏之,関島恒夫,武井延之
- Organizer
  ３６回日本分子生物学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25430064
[Presentation] 神経細胞における翻訳調節2012
- Author(s)
  武井延之
- Organizer
  シンポジウム「シナプス伝達機構の理解」
- Place of Presentation
  上智大学(招待講演)
- Year and Date
  2012-03-10
- Data Source
  KAKENHI-PROJECT-22500329
[Presentation] 神経細胞における翻訳調節:活動依存性と空間的特性2011
- Author(s)
  武井延之、那波宏之
- Organizer
  84回生化学会シンポジウム「翻訳制御の多様性」
- Place of Presentation
  京都(オーガナイザー)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22500329
[Presentation] 神経細胞における翻訳調節:活動依存性と空間的特性2011
- Author(s)
  武井延之、那波宏之
- Organizer
  第84回日本生化学会シンポジウム2S6a「翻訳制御の多様性」
- Place of Presentation
  京都国際会館(招待講演)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22500329
[Presentation] 神経細胞ではAMPKが成長因子によるmTORC1シグナル活性化と蛋白合成促進をドミナントに制御する。2011
- Author(s)
  武井延之
- Organizer
  BMB2010(生化学会/分子生物学会合同年会)
- Place of Presentation
  神戸
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-22500329
[Presentation] Atomic Force Microscopic Imaging of Growth Cones from Rat Dorsal Root Ganglion Neurons
- Author(s)
  Osamu Hoshi, Yuichiro Cho, Nobuyuki Takei
- Organizer
  ISN Special Conference
- Place of Presentation
  Yayoi Auditorium, The University of Tokyo, Tokyo
- Year and Date
  2014-09-20 – 2014-09-22
- Data Source
  KAKENHI-PROJECT-25430064
[Presentation] Translational machinery and protein synthesis in growth cones of rat dorsal root ganglion neurons; atomic force microscopic and fluoresence microscopic analysis
- Author(s)
  Hoshi O., Cho Y., Takei N
- Organizer
  The 120th Annual Meeting of the Japanese Association of Anatomists
- Place of Presentation
  神戸（兵庫県）
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-24590248

1. Nawa Hiroyuki (50183083)

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2. KAKITA Akiyoshi (80281012)

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3. NAMBA Hisaaki (90332650)

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4. Nambu Atsushi (80180553)

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5. HOSHI Osamu (10303124)

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6. CHO Yuichiro (90334432)

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7. Kobayashi Kazuto (90211903)

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9. Kitamura Nobutaka (90224972)

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Takei Nobuyuki 武井 延之

TAKEI Nobuyuki 武井 延之

武井 延之 タケイ ノブユキ

TAKEI N. 武井 延之

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Mechanisms of cell size control during normal and abnormal neural developmentPrincipal Investigator

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Regulation of neuronal cell size control in normal and disease conditionPrincipal Investigator

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Molecular mechanisms underlying axonal local protein synthesis in neuronsPrincipal Investigator

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局所的mRNA翻訳マシナリーの活性化と脳高次機能Principal Investigator

Takei Nobuyuki 武井延之

TAKEI Nobuyuki 武井延之

武井延之タケイノブユキ

TAKEI N. 武井延之