Okada Yasunori 岡田保典

… Alternative Names

OKADA YASUNORI 岡田保典

OKADA Yasunori 岡田保典

岡田保典オカダヤスノリ

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Researcher Number	00115221
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 特任教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 順天堂大学, 大学院医学研究科, 特任教授 2020: 順天堂大学, 医学(系)研究科(研究院), 特任教授 2016 – 2020: 順天堂大学, 医学(系)研究科(研究院), 客員教授 2017: 順天堂大学, 医学部, 客員教授 1997 – 2014: Keio University, School of Medicine, Pathology, Professor, 医学部, 教授 … More 2007: School of Medicine, Professor 1998 – 1999: 慶応義塾大学, 医学部, 教授 1996: 金沢大学, がん研究所・分子免疫, 教授 1994 – 1996: 金沢大学, がん研究所, 教授 1993: 金沢大学, 医療短期大学部, 助教授 1990 – 1993: 金沢大学, 医療技術短期大学部, 助教授 1988: 金沢大学, 医療技術短期大学部, 助教授 Less
Review Section/Research Field	Principal Investigator Human pathology / Biological Sciences / Experimental pathology / Experimental pathology / Basic Section 49030:Experimental pathology-related / Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Experimental pathology / Human pathology … More / Basic Section 49030:Experimental pathology-related / Functional basic dentistry / Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Kidney internal medicine / Human pathology / Experimental pathology Less
Keywords	Principal Investigator マトリックスメタロプロテアーゼ / ADAM / 変形性関節症 / 慢性関節リウマチ / MMP / 関節軟骨破壊 / 細胞外マトリックス分解 / 分解 / Matrix metalloproteinase / ノックアウトマウス … More / 転移 / 細胞外マトリックス / 酵素 / 浸潤・転移 / HYBID / TIMP / ヒアルロン酸 / ADAMTS4 / 基質 / プロテオグリカン / 浸潤 / 活性化 / 組織破壊 / 免疫組織化学的局在 / ヒアルロン酸分解 / CD151 / HMG / 膜型MMP / 癌細胞浸潤 / Cartilage destruction / Osteoarthritis / Rheumatoid arthritis / 腎癌 / 血管 / ELISA / 細胞増殖 / プロテアーゼ / アグリカナーゼ / 血管新生 / 心筋梗塞 / MMPインヒビター / 遺伝子欠損マウス / 増殖因子 / 細胞外マトリックス代謝 / グリオーマ / 関節軟骨 / 局在 / 子宮内膜癌 / 乳癌 / 癌細胞浸潤・転移 / 潜在型酵素活性化 / メタロプロティナ-ゼ / 組織破壊・修復 / CEMIP / IL-6 / TMEM2 / 画像診断 / 組織内微小環境 / 関節軟骨破壊再生 / 骨軟骨棘 / 変形性膝関節症 / 画像解析 / 骨棘 / 早期変形性関節症診断 / ADAMTS4/5 / 関節軟骨破壊機構 / ADAMTS / 滑膜細胞 / 関節軟骨細胞 / 骨・軟骨代謝 / ヒアルロン酸代謝 / 早期変形性関節症 / 早期変形性膝関節症 / アグリカン分解 / wound healing / knockout mice / regeneration / tissue destruction / osteoarthritis / MMP-2ノックアウトマウス / 腫瘍浸潤・転移 / 創傷 / 再生 / Arteriosclerosis / Transgenic and knockout mouse / Invasion and metastasis / Gene expression / Membrane type MMP / 遺伝子発見 / 動脈硬化 / 遺伝子改変マウス / 遺伝子発現 / MMP inhibitors / Activation of proMMP / 関節液 / マトリックスメタロプロイナーゼ / Metastasis / Cancer invasion / Tissue destruction / Transgenic mice / ECM degradation / トランスジェニックマウス / ゼラチナーゼA / 遺伝子導入マウス / Activation / Cytokine / Tissue inhibitor / Degradation / 関節破壊 / サイトカイン / 組織インヒビター / インヒビター / メタロプロティナーゼ / EMT / 急性大動脈解離 / 悪性腫瘍 / 組織リモデリング / フォンビルブラント因子 / アポトーシス / 増殖 / von Willebrand factor / ヘパラナーゼ / 筋線維芽細胞 / カルシウムペントサン硫酸 / CD44 / IL-1 / 癌転移 / セマフォリン / 動脈瘤 / エンドスタチン / 創傷治癒 / タンパク分解 / P-selectin / PSGL-1 / 炎症細胞浸潤 / 細胞接着 / 発現 / モニター / 病期 / 肺癌 / IGFBP-3 / IGF-I / マトリックスメタロプロテーゼ / ADAMプロテアーゼ / 軟骨 / フィブロネクチン / ADAM MMP基質 / タンパク結合 / Vascular endothelial growth factor / Connective tissue growth factor / VEGF / CTGF / クローニング / マトリクライン / 形態形成 / 細胞・組織 / 内皮細胞増殖因子 / 血管新生阻害 / 血管内皮増殖因子 / 胃癌 / 酵素活性化 / 癌細胞転移 / 細胞膜貫通型プロテアーゼ / 関節組織破壊 / メタロプロテナーゼ / 骨吸収 / パンヌス / マイナ-コラ-ゲン … More Except Principal Investigator VEGF / MMP / 細胞外マトリックス / 浸潤 / 網膜症 / 糖尿病 / 低酸素 / 癌転移 / Blood-retinal barrier / 血液網膜関門 / 血管新生 / ADAM / claudin-5 / 転移 / Fibulin-7 / 組織内微小環境 / フィビュリン-7 / 神経膠腫 / Hypoxia / MT1-MMP / chondrocyte / 肺癌 / VWF / 炎症 / アポトーシス / 癌細胞増殖 / 血液脳関門 / メタロプロテアーゼ / 転移抑制遺伝子 / NM23 / がん / TIMP / 癌細胞の浸潤・増殖 / がん関連線維芽細胞（CAF） / 線維性癌間質反応 / 大腸癌 / 軟骨摩耗 / 半月板逸脱 / 骨棘 / 軟骨下骨病変 / 変形性膝関節症 / microRNA / 遺伝子 / HYBID / 細胞浸潤 / ECM微小環境（ニッチ） / 神経膠腫（グリオーマ） / インプラント関連感染 / メタボローム解析 / インプラント関連感染症 / 感染症 / 骨軟部組織 / 血管形成 / 腫瘍 / 小環境 / 組織内微 / 周皮細胞 / 血管内皮細胞 / 異常血管形成 / Nephrotic syndrome / Renal iniury / Gelatinase / Collagenase / ネフローゼ症候群 / 腎障害 / ゲラチナーゼ / コラゲナーゼ / Claudin-5 / Retinopathy / Diabetus mellitus / Claudin / Retinal edema / Angiogenesis / Diabetic retinopathy / claudin / 活性酸素種 / 網膜浮腫 / 糖尿病網膜症 / glial cell / angiogenesis / retinopathy / diabetes mellitus / グリア細胞 / Blood-brain barrier / Cerebral blood vessels / 個体発生 / 脳血管 / biomatenal / collagen / integrin / RGD-CAP / CMP / 線維芽細胞 / 生体材料 / インテグリン / RGD / 軟骨細胞 / 繊維芽細胞 / 接着因子 / コラーゲン / inflammation / amiroid / interleukin-1 / osteonectin / cartilage / インターロイキン-1 / アミロイド / オステオネクチン / 軟骨 / 骨 / ヒト型抗体 / 分子標的治療 / 分子標的 / ルシフェラーゼ / バイオイメージング / 乳癌 / CTGF / CSF-1 / Ectodomain Shedding / 骨代謝学 / 免疫学 / TACE / ADAM17 / 骨・軟骨代謝学 / 癌細胞の増殖 / Yeast two-hybrid法 / 癌浸潤・転移 / Yeast two-hybrid / ADAMTS / von Willebrand factor / vWF / 転移関連遺伝子 / 膜型メタロプロテアーゼ / 細胞外マトリックス分解 / 転移・浸潤 / 胎盤形成 / マトリックス、メタロプロテアーゼ / がん浸潤・転移 / カルポニン / マトリックスメタロプロテアーゼ / 癌 / 72-kDa typeIV Collagenase / 92-kDa typeIV Collagenase / 細胞外マトリックス分解酵素 / 転移遺伝子 / メタロプロテイナーゼ / βmアクチン / NDPキナ-ゼ / メタロプロテア-ゼ / がん悪性化 / 浸潤転移 Less

変形性膝関節症発症・進展における骨棘の意義と形成調節機構Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Juntendo University
Pathophysiology and mechanism of the progression of subchondral bone lesions in knee osteoarthritis
- Principal Investigator
  
  石島旨章
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Juntendo University
大腸癌進展に関わる癌間質モジュレーターの機能解析
- Principal Investigator
  
  望月早月
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Defense Medical College
Expression and functional analysis of hyaluronan-degrading molecule HYBID and its role in tissue destruction and repairPrincipal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Juntendo University
Analytical study of infiltrating advanced extracellular matrix microenvironment (niche) of glioma
- Principal Investigator
  
  デベガスサーナ
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Juntendo University
Decipher cell-cell interactions
- Principal Investigator
  
  廣畑聡
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Okayama University
Pathophysiological study and image analysis of early-stage knee OA by focusing on osteochondrophytesPrincipal Investigator
- Principal Investigator
  
  Okada Yasunori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Juntendo University
Functional analysis of fibulin-7 in glioma
- Principal Investigator
  
  de Vega Susana
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University
Mechanism of articular cartilage destruction in early-stage osteoarthritis and preclinical study on the development of diagnosis and treatment for early-stage osteoarthritis.Principal Investigator
- Principal Investigator
  
  Yasunori Okada
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Juntendo University
Establishment of early diagnosis and treatment in the patient with the surgical site infection
- Principal Investigator
  
  ISHII KEN
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  International University of Health and Welfare
  Keio University
Pathological study on metalloproteinases in tissue remodeling under pathological conditionsPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Research and development of human neutralizing antibodies aiming at treatment of non-small cell lung carcinoma
- Principal Investigator
  
  MOCHIZUKI Satsuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Functional analysis of ADAM28 on cancer cells by bioluminescence imaging
- Principal Investigator
  
  MOCHIZUKI Satsuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
ADAM28の癌細胞増殖・浸潤・転移における作用解析Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Functional analyses and regulation of the metabolism of tissue microenvironmental factors by metalloproteinasesPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Expression of claudin-5 in brain vascular endothelial cells under hypoxia
- Principal Investigator
  
  IKEDA Eiji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Yamaguchi University
  Keio University
ADAM28 cleaves von Willebrand factor and induces cancer cell metastasis
- Principal Investigator
  
  SATSUKI Mochizuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Studies of TACE in bone biology and inflammatory diseases
- Principal Investigator
  
  HORIUCHI Keisuke
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
ADAM28の肺癌患者におけるモニターと新規基質解析Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
細胞外環境モジュレーター分子ADAMの機能解析Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
ADAM28のヒト乳癌組織での発現と癌細胞の増殖・運動・浸潤への関与Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Molecular mechanisms underlying the retinal vascular lesions in diabetic retinopathy
- Principal Investigator
  
  IKEDA Eiji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
Role of collagenases and gelatinases in renal injury and their, therapeutic applications
- Principal Investigator
  
  SASAMURA Hiroyuki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Pathological studies on the tissue destruction by metalloproteinasesPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
ADAMTS4(aggrecanase-1)の軟骨組織内活性調節因子の網羅的探索Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Molecular mechanisms underlying the vascular lesions in proliferative diabetic retinopathy
- Principal Investigator
  
  IKEDA Eiji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
膜型ADAM結合分子のクローニングと機能解析Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Molecular mechanisms of the pathological angiogenesis in proliferative diabetic retinopathy.
- Principal Investigator
  
  IKEDA Eiji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
ヒトグリオーマの浸潤と脳細胞外マトリックス分解Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Keio University
細胞外マトリックス代謝研究の新展開の総括Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1999 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
マトリックスメタロプロテアーゼの新規機能解析Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1999 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Molecular mechanisms of the blood-brain barrier induction in cerebral blood vessels
- Principal Investigator
  
  IKEDA Eiji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Regulation of MT1-MMP gene expression by HMGI-CPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
性ホルモン依存性癌組織におけるマトリックスメタロプロテアーゼの発現Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Keio University
VEGFに結合するマトリックス成分とその分解による活性調節機構Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Molecular Pathology of Cartilage destruction in Rheumatoid ArthritisPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
性ホルモン依存性癌組織におけるストリックスメタロプロテアーゼの発現Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
Biomaterial having active sites of collagen-binding adhesion molecules (CMP and RGD-CAP)
- Principal Investigator
  
  KATO Yukio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
がん細胞の転移と浸潤の分子生物学
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kanazawa University
細胞膜表面におけるマトリックス分解の分子機構Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
  Kanazawa University
Analyzes on ECM metabolism in transgenic and knockout micePrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Experimental pathology
- Research Institution
  School of Medicine, Keio University
  Kanazawa University
Studies on the destruction of articular cartilage by matrix metalloproteinasesPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
MMP-2(ゼラチナーゼA)の関節組織破壊における役割Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
Novel factors that increase inflammation : tissue and synovial fluid levels.
- Principal Investigator
  
  KATO Yukio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
がん細胞の浸潤性獲得の分子機構
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
慢性関節リウマチ関節破壊におけるMMP-7(pump-1)の役割Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
がん細胞の浸潤性獲得の分子機構
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
慢性関節リウマチの骨破壊に関する研究Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
がん細胞の浸潤性獲得の分子機構
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
慢性関節リウマチパンヌスに関する研究Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
慢性関節リウマチと変形性関節症におけるIX型コラ-ゲンPrincipal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
コラーゲン分解酵素とそのインヒビターの慢性関節リウマチ滑膜組織における局在Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University

[Book] Kelley and Firestein's Textbook of Rheumatology.2017
- Author(s)
  Okada Y.
- Publisher
  Elsevier Inc.
- Data Source
  KAKENHI-PROJECT-16H05454
[Book] Kelley's Textbook of Rheumatology.2015
- Author(s)
  Okada Y.
- Publisher
  Elsevier Saunders.
- Data Source
  KAKENHI-PROJECT-24249022
[Book] Kelley's Textbook of Rheumatology.2013
- Author(s)
  Okada Y
- Publisher
  Elsevier Saunders
- Data Source
  KAKENHI-PROJECT-24249022
[Book] Kelley's Textbook of Rheumatology2013
- Author(s)
  Okada Y.
- Publisher
  Elsevier Saunders
- Data Source
  KAKENHI-PROJECT-24249022
[Book] Handbook of Proteolytic Enzymes2013
- Author(s)
  Satsuki Mochizuki and Yasunori Okada
- Total Pages
  4094
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-24590490
[Book] Handbook of Proteolytic Enzymes.2013
- Author(s)
  Mochizuki S. and Okada Y.
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-24249022
[Book] Handbook of Proteolytic Enzymes2013
- Author(s)
  Satsuki Mochizuki and Yasunori Okada
- Publisher
  Elsevier Ltd
- Data Source
  KAKENHI-PROJECT-24590490
[Book] Handbook of Proteolytic Enzymes2013
- Author(s)
  Mochizuki S. and Okada Y.
- Publisher
  Elsevier Ltd
- Data Source
  KAKENHI-PROJECT-24249022
[Book] Handbook of Proteolytic Enzymes2012
- Author(s)
  Mochizuki S., Okada Y.
- Publisher
  ADAM28(In press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Proteinases and matrix degradation. In Kelley's Textbook of Rheumatology2012
- Author(s)
  Okada Y, Firestein G. S., Budd R. C., Gabriel S. E., McInnes I. B. and O' Dell J. R
- Publisher
  Philadelphia(in press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Kelley's Textbook of Rheumatology, 9th edition2012
- Author(s)
  Okada Y.
- Publisher
  Proteinases and matrix degradation(In press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] ADAM28. In : Handbook of Proteolytic Enzymes2012
- Author(s)
  Mochizuki S. and Okada Y Rawlings N. D. and Salvesen G
- Publisher
  Elsevier Ltd(in press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] ADAM28.In : Handbook of Proteolytic Enzymes.2011
- Author(s)
  Mochizuki S., Okada.
- Publisher
  Elsevier Ltd, Oxford, UK.(in press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Proteinases and matrix degradation. In Kelley's Textbook of Rheumatology.2011
- Author(s)
  Okada Y.
- Publisher
  Elsevier Saunders.Philadelphia, USA.(in press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] 第1章MMP/TIMP pp66-68,第6章線維化pp458-460「日本血管生物医学事典」2011
- Author(s)
  望月早月、岡田保典
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21590421
[Book] Immunohistochemistry of MMPs and TIMPs. In Matrix Metalloproteinase Protocols2010
- Author(s)
  Okada Y
- Publisher
  Humana Press Inc
- Data Source
  KAKENHI-PROJECT-19109004
[Book] In Matrix Metalloproteinases. Ed. by Ian M. Clark. Humana Press Inc., Totowa, NJ, USA.2009
- Author(s)
  Okada Y.
- Publisher
  Immuno histochemistry of MMPs and TIMPs(in press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Kelley's Textbook of Rheumatology2009
- Author(s)
  Okada Y.
- Publisher
  Elsevier Saunders
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Kelley's Textbook of Rheumatology.(Proteinases and matrix degradation.)2009
- Author(s)
  Okada Y.
- Total Pages
  19
- Publisher
  Elsevier Saunders.
- Data Source
  KAKENHI-PROJECT-19109004
[Book] In Kelley's Textbook of Rheumatology. Ed. by Firestein G. S., Budd R. C., Harris E. D., Jr., Mclnnes I. B., Ruddy s. and Sergent J. S. 8th edition. Elsevier Saunders. Philadelphia.2009
- Author(s)
  Okada Y.
- Publisher
  Proteinases and matrix degradation.
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Proteinases and matrix degradation.(Ed. by Harris E. D., Jr., Budd R. C., Ruddy S., Genovese M.C., Firestein G. S. and Sargent J. S. 8th edition.)2007
- Author(s)
  Okada Y.
- Publisher
  Kelley's Textbook of Rheumatology. Elsevier Saunders. Philadelphia.(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Book] Proteinases and matrix degradation.2007
- Author(s)
  Okada Y.
- Publisher
  Kelley's Textbook of Rheumatology. Ed. by Harris E. D., Jr., Budd R. C., Ruddy S., Genovese M. C., Firestein G. S. and Sargent J. S. 8th edition, Elsevier Saunders. Philadelphia,(In press)
- Data Source
  KAKENHI-PROJECT-16209015
[Book] TIMP-1, MMP-1, α2Mとは「日本医事新報」2007
- Author(s)
  望月早月、岡田保典
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-19590404
[Book] 7th edition, Elsevier Saunders. Philadelphia2005
- Author(s)
  Okada Y.
- Publisher
  Proteinases and matrix degradation. In Kelley's Textbook of Rheumatology. Ed. by Harris E.D., Jr., Budd R.C., Ruddy S., Genovese M.C., Firestein G.S. and Saruent J.S.
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] IL-6 Reduces Spheroid Sizes of Osteophytic Cells Derived from Osteoarthritis Knee Joint via Induction of Apoptosis2024
- Author(s)
  Negishi Yoshifumi、Adili Arepati、de Vega Susana、Momoeda Masahiro、Kaneko Haruka、Cilek Mehmet Z.、Yoshinaga Chiho、Takafuji Kazuaki、Otsuka Yuta、Shimoda Masayuki、Negishi-Koga Takako、Ishijima Muneaki、Okada Yasunori
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 194 Issue: 1 Pages: 135-149
- DOI
  10.1016/j.ajpath.2023.10.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09259, KAKENHI-PROJECT-22K07029, KAKENHI-PROJECT-18K09082
[Journal Article] 早期変形性膝関節症の関節軟骨破壊機構と早期診断2023
- Author(s)
  塩澤　淳、石島旨章、岡田保典
- Journal Title
  
  整形・災害外科
  
  Volume: 66 Pages: 1401-1409
- Data Source
  KAKENHI-PROJECT-22K07029
[Journal Article] Periostin derived from cancer-associated fibroblasts promotes esophageal squamous cell carcinoma progression via ADAM17 activation.2023
- Author(s)
  Yusuke Ishibashi, Satsuki Mochizuki *, Keisuke Horiuchi, Hironori Tsujimoto, Keita Kouzu, Yoji Kishi , Yasunori Okada and Hideki Ueno
- Journal Title
  
  BBA-Molecular Basis of Disease
  
  Volume: 1869 Issue: 5 Pages: 166669-166669
- DOI
  10.1016/j.bbadis.2023.166669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06958, KAKENHI-PROJECT-22K07029, KAKENHI-PROJECT-23K27678
[Journal Article] Medial meniscus extrusion is invariably observed and consistent with tibial osteophyte width in elderly populations: The Bunkyo Health Study2023
- Author(s)
  Negishi Y、Kaneko H、Aoki T、Liu L、Adili A、Arita H、Hada S、Momoeda M、Huang H、Tomura J、Wakana S、Shiozawa J、Kubota M、Someya Y、Tamura Y、Aoki S、Watada H、Kawamori R、Negishi-Koga T、Okada Y、Ishijima M
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 22805-22805
- DOI
  10.1038/s41598-023-49868-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15750, KAKENHI-PROJECT-21K09259, KAKENHI-PROJECT-22K07029, KAKENHI-PROJECT-18K09082
[Journal Article] Anterior meniscus extrusion is associated with anterior tibial osteophyte width in knee osteoarthritis ? The Bunkyo Health Study2023
- Author(s)
  Adili Arepati、Kaneko Haruka、Aoki Takako、Liu Lizu、Negishi Yoshifumi、Tomura Jun、Wakana Suguru、Momoeda Masahiro、Arita Hitoshi、Hada Shinnosuke、Shiozawa Jun、Kubota Mitsuaki、Someya Yuki、Tamura Yoshifumi、Aoki Shigeki、Watada Hirotaka、Kawamori Ryuzo、Negishi-Koga Takako、Okada Yasunori、Ishijima Muneaki
- Journal Title
  
  Osteoarthritis and Cartilage Open
  
  Volume: 5 Issue: 3 Pages: 100364-100364
- DOI
  10.1016/j.ocarto.2023.100364
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15750, KAKENHI-PROJECT-21K09259, KAKENHI-PROJECT-22K07029, KAKENHI-PROJECT-18K09082
[Journal Article] Medial meniscus extrusion is directly correlated with medial tibial osteophyte in patients received reconstruction surgery for anterior cruciate ligament injury: A longitudinal study.2022
- Author(s)
  Hada S., Kaneko H., Liu L., Aoki T., Takamura T., Kinoshita M., Arita H., Shiozawa J., Negishi Y., Momoeda M., Kubota M., Aoki S., Okada Y. and Ishijima M.
- Journal Title
  
  Osteoarthr Cartil Open
  
  Volume: 4 Pages: 100320-100320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07029
[Journal Article] Expression and regulation of recently discovered hyaluronidases, HYBID and TMEM2, in chondrocytes from knee osteoarthritic cartilage2022
- Author(s)
  Shiozawa Jun、de Vega Susana、Yoshinaga Chiho、Ji Xang、Negishi Yoshifumi、Momoeda Masahiro、Nakamura Tomomi、Yoshida Hiroyuki、Kaneko Haruka、Ishijima Muneaki、Okada Yasunori
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 17242-17242
- DOI
  10.1038/s41598-022-22230-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09082, KAKENHI-PROJECT-22K07029, KAKENHI-PROJECT-20K18075
[Journal Article] Cancer-associated fibroblasts at the unfavorable desmoplastic stroma promote colorectal cancer aggressiveness: Potential role of ADAM92022
- Author(s)
  Ao T, Mochizuki S, Kajiwara Y, Yonemura K, Shiraishi T, Nagata K, Shinto E, Okamoto K, Nearchou IP, Shimazaki H, Kishi Y, Okada Y, Ueno H
- Journal Title
  
  Int J Cancer
  
  Volume: 150 Issue: 10 Pages: 1706-1721
- DOI
  10.1002/ijc.33947
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06958, KAKENHI-PROJECT-22K07029
[Journal Article] Synergistic upregulation of ADAMTS4 (aggrecanase-1) by cytokines and its suppression in knee osteoarthritic synovial fibroblasts2021
- Author(s)
  Cilek Mehmet Zeynel、de Vega Susana、Shiozawa Jun、Yoshinaga Chiho、Miyamae Yuka、Chijiiwa Miyuki、Mochizuki Satsuki、Ito Masatoshi、Kaneko Haruka、Kaneko Kazuo、Ishijima Muneaki、Okada Yasunori
- Journal Title
  
  Laboratory Investigation
  
  Volume: 102 Issue: 1 Pages: 102-111
- DOI
  10.1038/s41374-021-00685-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03788, KAKENHI-PROJECT-21K06958, KAKENHI-PROJECT-20K18075, KAKENHI-PROJECT-18K09082, KAKENHI-PROJECT-22K07029
[Journal Article] An antibacterial coated polymer prevents biofilm formation and implant-associated infection2021
- Author(s)
  Ishihama Hiroko、Ishii Ken、Nagai Shigenori、Kakinuma Hiroaki、Sasaki Aya、Yoshioka Kenji、Kuramoto Tetsuya、Shiono Yuta、Funao Haruki、Isogai Norihiro、Tsuji Takashi、Okada Yasunori、Koyasu Shigeo、Toyama Yoshiaki、Nakamura Masaya、Aizawa Mamoru、Matsumoto Morio
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 3602-3602
- DOI
  10.1038/s41598-021-82992-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] Medial meniscus extrusion is a determinant factor for the gait speed among MRI-detected structural alterations of knee osteoarthritis2021
- Author(s)
  Arita Hitoshi、Kaneko Haruka、Ishibashi Masayoshi、Sadatsuki Ryo、Liu Lizu、Hada Shinnosuke、Kinoshita Mayuko、Aoki Takako、Negishi Yoshifumi、Momoeda Masahiro、Adili Arepati、Kubota Mitsuaki、Okada Yasunori、Kaneko Kazuo、Ishijima Muneaki
- Journal Title
  
  Osteoarthritis and Cartilage Open
  
  Volume: 3 Issue: 3 Pages: 100176-100176
- DOI
  10.1016/j.ocarto.2021.100176
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03788, KAKENHI-PROJECT-18K09082
[Journal Article] Deletion of Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization (HYBID) Results in Attenuation of Osteoarthritis in Mice2021
- Author(s)
  Momoeda Masahiro、de Vega Susana、Kaneko Haruka、Yoshinaga Chiho、Shimoda Masayuki、Nakamura Tomomi、Endo Yoko、Yoshida Hiroyuki、Kaneko Kazuo、Ishijima Muneaki、Okada Yasunori
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 191 Issue: 11 Pages: 1986-1998
- DOI
  10.1016/j.ajpath.2021.07.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07422, KAKENHI-PROJECT-19H03788, KAKENHI-PROJECT-18K09082
[Journal Article] HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth2021
- Author(s)
  Tsuji Shohei、Nakamura Shinsuke、Yamada Tetsuya、de Vega Susana、Okada Yasunori、Inoue Shintaro、Shimazawa Masamitsu、Hara Hideaki
- Journal Title
  
  Brain Research
  
  Volume: 1764 Pages: 147490-147490
- DOI
  10.1016/j.brainres.2021.147490
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07429, KAKENHI-PROJECT-19H03788
[Journal Article] Plasma Arginase-1 Level Is Associated with the Mental Status of Outpatients with Chronic Liver Disease.2021
- Author(s)
  Ogino N, Ikeda F, Namba S, Ohkubo S, Nishimura T, Okada H, Hirohata S, Suganuma N, Ogino K.
- Journal Title
  
  Diagnostics
  
  Volume: 11 Issue: 2 Pages: 317-317
- DOI
  10.3390/diagnostics11020317
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17067, KAKENHI-PROJECT-20H00548
[Journal Article] 総論　変形性膝関節症における軟骨細胞外マトリックス分解の分子病態2021
- Author(s)
  塩澤淳、石島旨章、岡田保典
- Journal Title
  
  Pharma Medica
  
  Volume: 39 Pages: 19-23
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] 早期変形性膝関節症におけるHA分解酵素HYBID（CEMIP/KIAA1199）の意義2021
- Author(s)
  塩澤淳、石島旨章、岡田保典
- Journal Title
  
  整形・災害外科
  
  Volume: 64 Pages: 253-261
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] Hyaluronan degradation by Cemip regulates host defense against Staphylococcus aureus skin infection.2020
- Author(s)
  Dokoshi T., Zhang L., Li F., Nakatsuji T., Butcher A., Yoshida H., Shimoda M., Okada Y. and Gallo R.L.
- Journal Title
  
  Cell Rep
  
  Volume: 30 Issue: 1 Pages: 61-68
- DOI
  10.1016/j.celrep.2019.12.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] Expression and characterization of hyaluronan binding protein involved in hyaluronan depolymerization: HYBID, alias KIAA1199 and CEMIP.2020
- Author(s)
  de Vega S., Yoshida H. and Okada Y.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2132 Pages: 129-138
- DOI
  10.1007/978-1-0716-0430-4_13
- ISBN
  9781071604298, 9781071604304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03788, KAKENHI-PROJECT-20K07429
[Journal Article] 線維症とメタロプロテアーゼーMMP・ADAM・ADAMTS2020
- Author(s)
  望月早月、岡田保典
- Journal Title
  
  医学の歩み
  
  Volume: 275 Pages: 21450-21456
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] HYBID（KIAA1199/CEMIP）2020
- Author(s)
  塩澤淳、岡田保典
- Journal Title
  
  整形外科
  
  Volume: 71 Pages: 357-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] HYBID and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts.2020
- Author(s)
  Yoshida H., Aoki M., Komiya A., Sakai S., Sayo T., Okada Y., and Takahashi Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 295 Issue: 8 Pages: 2483-2494
- DOI
  10.1074/jbc.ra119.010457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] Stromal metalloproteinases: Crucial contributors to the tumor microenvironment2020
- Author(s)
  Shimoda Masayuki、Ohtsuka Takashi、Okada Yasunori、Kanai Yae
- Journal Title
  
  Pathology International
  
  Volume: 71 Issue: 1 Pages: 1-14
- DOI
  10.1111/pin.13033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07422, KAKENHI-PROJECT-19H03788
[Journal Article] Expression and Characterization of Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization: HYBID, Alias KIAA1199 and CEMIP.2020
- Author(s)
  de Vega S, Yoshida H, Okada Y
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2132 Pages: 129-138
- DOI
  10.1007/978-1-0716-0430-4_1
- ISBN
  9781071604298, 9781071604304
- Data Source
  KAKENHI-PROJECT-17K08770
[Journal Article] Implication of HYBID (Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization) in Hyaluronan Degradation by Synovial Fibroblasts in Patients with Knee Osteoarthritis.2020
- Author(s)
  Shiozawa J, de Vega S, Cilek MZ, Yoshinaga C, Nakamura T, Kasamatsu S, Yoshida H, Kaneko H, Ishijima M, Kaneko K, Okada Y.
- Journal Title
  
  American Journal of Pathology
  
  Volume: 190 Issue: 5 Pages: 1046-1058
- DOI
  10.1016/j.ajpath.2020.01.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09083, KAKENHI-PROJECT-17K08770, KAKENHI-PROJECT-18K09082, KAKENHI-PROJECT-20K18075, KAKENHI-PROJECT-19H03788, KAKENHI-PROJECT-20K07429
[Journal Article] Fibulin-7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin-12019
- Author(s)
  Susana de Vega, Akihide Kondo, MarioSuzuki, Hajime Arai, Shabierjiang Jiapaer, Hemragul Sabit, Mitsutoshi Nakada, Tomoko Ikeuchi, Muneaki Ishijima, Eri Arikawa-Hirasawa, Yoshihiko Yamada and Yasunori Okada
- Journal Title
  
  International Journal of Cancer
  
  Volume: xx Issue: 8 Pages: 2157-2169
- DOI
  10.1002/ijc.32306
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08770, KAKENHI-PROJECT-18K07535, KAKENHI-PROJECT-18K09082, KAKENHI-PROJECT-18H02910
[Journal Article] Inhibitory effects of Sanguisorba officinalis root extract on HYBID (KIAA1199)-mediated hyaluronan degradation and skin wrinkling2019
- Author(s)
  Yoshida H.、Yamazaki K.、Komiya A.、Aoki M.、Kasamatsu S.、Murata T.、Sayo T.、Cilek M. Z.、Okada Y.、Takahashi Y.
- Journal Title
  
  International Journal of Cosmetic Science
  
  Volume: 41 Issue: 1 Pages: 12-20
- DOI
  10.1111/ics.12505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-19H03788
[Journal Article] 変形性膝関節症におけるHYBID（CEMIP/KIAA1199）の発現と役割―早期変形性膝関節症のバイオマーカーとしての可能性も含めてー2019
- Author(s)
  塩澤淳, 石島旨章, 金子和夫, 岡田保典
- Journal Title
  
  整形・災害外科
  
  Volume: 62 Pages: 1519-1525
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] Role of HYBID (Hyaluronan Binding Protein Involved in Hyaluronan Depolymerization), Alias KIAA1199/CEMIP, in Hyaluronan Degradation in Normal and Photoaged Skin2019
- Author(s)
  Yoshida Hiroyuki、Okada Yasunori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 22 Pages: 5804-5804
- DOI
  10.3390/ijms20225804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] 変形性膝関節症における慢性疼痛2019
- Author(s)
  石島旨章、金子晴香、根岸義文、百枝雅裕、岡田保典、金子和夫
- Journal Title
  
  日本臨床
  
  Volume: 77 Pages: 2027-2034
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] Bone marrow lesion is associated with disability for activities of daily living in patients with early stage knee osteoarthritis2018
- Author(s)
  Sadatsuki Ryo、Ishijima Muneaki、Kaneko Haruka、Liu Lizu、Futami Ippei、Hada Shinnosuke、Kinoshita Mayuko、Kubota Mitsuaki、Aoki Takako、Takazawa Yuji、Ikeda Hiroshi、Okada Yasunori、Kaneko Kazuo
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 37 Issue: 3 Pages: 529-536
- DOI
  10.1007/s00774-018-0950-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09082, KAKENHI-PROJECT-18K09083, KAKENHI-PROJECT-16H05454
[Journal Article] Reduction of hyluronan and increased expression of HYBID (KIAA1199) correlate with clinical symptoms in photoaged skin.2018
- Author(s)
  Yoshida H., Nagaoka A., Komiya A., Aoki M., Nakamura S., Morikawa T., Ohtsuki R., Sayo T., Okada Y. and Takahashi Y.
- Journal Title
  
  Br J Dermatol
  
  Volume: in press Issue: 1 Pages: 136-144
- DOI
  10.1111/bjd.16335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454
[Journal Article] Inhibition of HYBID (KIAA1199)-mediated hyaluronan degradation and anti-wrinkle effect of Geranium thunbergii extract2018
- Author(s)
  Yoshida Hiroyuki、Yamazaki Kohei、Komiya Aya、Aoki Mika、Nakamura Tomomi、Kasamatsu Shinya、Murata Takeshi、Sayo Tetsuya、Okada Yasunori、Takahashi Yoshito
- Journal Title
  
  Journal of Cosmetic Dermatology
  
  Volume: - Issue: 4 Pages: 1-9
- DOI
  10.1111/jocd.12813
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-19H03788
[Journal Article] Relationship of hyaluronan and HYBID (KIAA1199) expression with roughness parameters of photoaged skin in Caucasian women2018
- Author(s)
  Yoshida H.、Komiya A.、Ohtsuki R.、Kusaka-Kikushima A.、Sakai S.、Kawabata K.、Kobayashi M.、Nakamura S.、Nagaoka A.、Sayo T.、Okada Y.、Takahashi Y.
- Journal Title
  
  Skin Research and Technology
  
  Volume: 24 Issue: 4 Pages: 562-569
- DOI
  10.1111/srt.12467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454
[Journal Article] Targeted deletion of HYBID (hyaluronan binding protein involved in hyaluronan depolymerization/ KIAA1199/CEMIP) decreases dendritic spine density in the dentate gyrus through hyaluronan accumulation2018
- Author(s)
  Yoshino Yuta、Shimazawa Masamitsu、Nakamura Shinsuke、Inoue Shintaro、Yoshida Hiroyuki、Shimoda Masayuki、Okada Yasunori、Hara Hideaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Issue: 3 Pages: 1934-1940
- DOI
  10.1016/j.bbrc.2018.07.138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-16J11526, KAKENHI-PROJECT-16K08719
[Journal Article] Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Is Up-Regulated and Involved in Hyaluronan Degradation in Human Osteoarthritic Cartilage.2018
- Author(s)
  Shimizu H, Shimoda M, Mochizuki S, Miyamae Y, Abe H, Chijiiwa M, Yoshida H, Shiozawa J, Ishijima M, Kaneko K, Kanaji A, Nakamura M, Toyama Y, Okada Y.
- Journal Title
  
  Am J Pathol.
  
  Volume: 188 Issue: 9 Pages: 2109-2119
- DOI
  10.1016/j.ajpath.2018.05.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10941, KAKENHI-PROJECT-18K07052, KAKENHI-PROJECT-18K09082, KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-16K08719
[Journal Article] Distribution and function of hyaluronan binding protein involved in hyaluronan depolymerization (HYBID, KIAA1199) in the mouse central nervous system2017
- Author(s)
  Yuta Yoshino, Mitsue Ishisaka, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hiroyuki Yoshida, Shintaro Inoue, Masayuki Shimoda, Yasunori Okada, Hideaki Hara
- Journal Title
  
  Neuroscience
  
  Volume: 347 Pages: 1-10
- DOI
  10.1016/j.neuroscience.2017.01.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J11526, KAKENHI-PROJECT-16H05454
[Journal Article] Imaging comparison between Chinese and Japanese patients with cervical ossification of the posterior longitudinal ligament2017
- Author(s)
  Xiao B, Nagoshi N, Takeuchi A, Mao J, Liu B, Tian W, Tsuji O, Okada E, Fujita N, Yagi M, Nakamura M, Matsumoto M, Ishii K, Watanabe K
- Journal Title
  
  Spine
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10457
[Journal Article] Hyaluronan-binding protein involved in hyaluronan depolymerization controls endothelial ossification through hyaluronan metabolism.2017
- Author(s)
  Shimoda M., Yoshida H., Mizuno S., Hirozane T., Horiuchi K., Yoshino Y., Hara H., Kanai Y., Inoue S., Ishijima M. and Okada Y.
- Journal Title
  
  Am J Pathol
  
  Volume: 187 Pages: 1162-1176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454
[Journal Article] Hyaluronan binding protein involved in hyaluronan depolymerization controls endothelial ossification through hyaluronan metabolism.2017
- Author(s)
  Shimoda M., Yoshida H., Mizuno S., Hirozane T., Horiuchi K., Yoshino Y., Hara H., Kanai Y., Inoue S., Ishijima M. and Okada Y.
- Journal Title
  
  Am J Pathol
  
  Volume: 187 Issue: 5 Pages: 1162-1176
- DOI
  10.1016/j.ajpath.2017.01.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-16J02900, KAKENHI-PROJECT-16J11526, KAKENHI-PROJECT-16K08719, KAKENHI-PROJECT-15K10494
[Journal Article] Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in the patients with eraly-stage knee osteoarthritis.2017
- Author(s)
  Hada S., Ishijima M., Kaneko H., Kinoshita M., Liu L., Sadatusuki R., Futami I., Yusup A., Takamura T., Arita H., Shiozawa J., Aoki T., Takazawa Y., Ikeda H., Aoki S., Kurosawa H., Okada Y. and Kaneko K.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 19 Issue: 1 Pages: 201-201
- DOI
  10.1186/s13075-017-1411-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-15K10494, KAKENHI-PROJECT-15K20019, KAKENHI-PROJECT-16K20069
[Journal Article] A Retrospective Cohort Study Comparing the Safety and Efficacy of Minimally Invasive Versus Open Surgical Techniques in the Treatment of Spinal Metastases2016
- Author(s)
  Hikata T, Isogai N, Shiono Y, Funao H, Okada E, Fujita N, Iwanami A, Watanabe K, Tsuji T, Nakamura M, Matsumoto M, Ishii K
- Journal Title
  
  Clin Spine Surg
  
  Volume: 00 Issue: 8 Pages: 1-6
- DOI
  10.1097/bsd.0000000000000460
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10457
[Journal Article] Osteoarthritis as a cause of locomotive syndrome: Its influence on functional mobility and activities of daily living.2016
- Author(s)
  Ishijima M., Kaneko H., Hada S., Kinoshita M., Sadatsuki R., Liu L., Shimura Y., Arita H., Shiozawa J., Yusup A., Futami I., Sakamoto Y., Ishibashi M., Machida S., Naito H., Arikawa-Hirasawa E., Hamada C., Saita Y., Takazawa Y., Ikeda H., Okada Y. and Kaneko K
- Journal Title
  
  Clinic Rev Bone Miner Metab
  
  Volume: 14 Issue: 2 Pages: 77-104
- DOI
  10.1007/s12018-016-9212-6
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05454
[Journal Article] Epithelial cell-derived a disintegrin and metalloproteinase-17 confers resistance to colonic inflammation through EGFR activation2016
- Author(s)
  Shimoda M, Horiuchi K, Sasaki A, Tsukamoto T, Okabayashi K, Hasegawa H, Kitagawa Y and Okada Y
- Journal Title
  
  EBioMedicine
  
  Volume: 5 Pages: 114-24
- DOI
  10.1016/j.ebiom.2016.02.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860276, KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-15K08960
[Journal Article] Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2)2016
- Author(s)
  Aya Shiraishi, Satsuki Mochizuki, Akira Miyakoshi, Kanehisa Kojoh and Yasunori Okada
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 469 Issue: 1 Pages: 62-29
- DOI
  10.1016/j.bbrc.2015.11.072
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08409, KAKENHI-PROJECT-16H05454
[Journal Article] CCN1 (Cyr61) is overexpressed in human osteoarthritic cartilage and inhibits ADAMTS4 (aggrecanase-1) activity2015
- Author(s)
  Miyuki Chijiiwa, Satsuki Mochizuki, Tokuhiro Kimura, Hitoshi Abe, Yukie Tanaka,Yutaka Fujii, Hidenori Shimizu, Hiroyuki Enomoto, Yoshiaki Toyama and Yasunori Okada
- Journal Title
  
  Arthritis Rheum
  
  Volume: in press Issue: 6 Pages: 1557-1567
- DOI
  10.1002/art.39078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590490
[Journal Article] CCN1 (Cyr61) is overexpressed in human osteoarthritic cartilage and inhibits ADAMTS4 (aggrecanase-1) activity.2015
- Author(s)
  Chijiiwa M., Mochizuki S., Kimura T., Abe H., Tanaka Y., Fujii Y., Shimizu H., Enomoto H., Toyama Y. and Okada Y.
- Journal Title
  
  Arthritis Rheum
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas.2015
- Author(s)
  Mikami S., Mizuno R., Kosaka T., Saya H., Oya M. and Okada Y.
- Journal Title
  
  Int J Cancer
  
  Volume: 136 Pages: 1504-1514
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Activation of aryl hydrocarbon receptor promotes invasion of clear cell renal cell carcinoma and is associated with poor prognosis and cigarette smoke.2015
- Author(s)
  Ishida M., Mikami S., Shinojima T., Kosaka T., Mizuno R., Kikuchi E., Miyajima A., Okada Y. and Oya M.
- Journal Title
  
  Int J Cancer
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture.2015
- Author(s)
  Anzai A., Shimoda M., Endo J., Kohno T., Katsumata ., Matsuhashi T., Yamamoto T., Ito K., Yan X., Shirakawa K., Shimizu-Hirota R., Yamada Y., Ueha S., Shinmura K., Okada Y., Fukuda K. and Sano M.
- Journal Title
  
  Circ Res
  
  Volume: 116 Pages: 612-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Heat-induced antigen retrieval in conventionally processed epon-embedded specimens: procedures and mechanisms.2014
- Author(s)
  Yamashita S. and Okada Y.
- Journal Title
  
  J Hictochem Cytochem
  
  Volume: 62 Pages: 584-597
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Invasion and metastasis of renal cell carcinoma.2014
- Author(s)
  Mikami S., Oya M., Mizuno R., Kosaka T., Katsube K. I. and Okada Y.
- Journal Title
  
  Med Mol Morphol
  
  Volume: 47 Pages: 63-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Loss of the TIMP gene family is sufficient for the acquisition of the CAF-like cell state.2014
- Author(s)
  Shimoda M., Principe S., Jackson H.W., Luga V., Fang H., Molyneux S.D., Shao Y.W., Aiken A., Waterhouse P.D., Karamboulas C., Hess F.M., Ohtsuka T., Okada Y., Ailles L., Ludwig A., Wrana J.L., Kislinger T. and Kohkha R.
- Journal Title
  
  Nat Cell Biol
  
  Volume: 16 Pages: 889-901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] The prognostic significance of vasohibin-1 expression in patients with prostate cancer.2013
- Author(s)
  Kosaka T, Miyazaki Y, Miyajima A, Mikami S, Hayashi Y, Tanaka N, Nagata H, Kikuchi E, Nakagawa K, Okada Y, Sato Y, Oya M
- Journal Title
  
  Br J Cancer.
  
  Volume: 108 Issue: 10 Pages: 2123-2129
- DOI
  10.1038/bjc.2013.169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591777, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24890230
[Journal Article] Mechanisms of angiogenic suppression in uteri exposed to diethylstilbestrol neonatally in the mouse.2013
- Author(s)
  Yamashita S., Kudo A., Kawakami H. and Okada Y.
- Journal Title
  
  Biol Reprod
  
  Volume: 88 Issue: 5 Pages: 1-13
- DOI
  10.1095/biolreprod.112.106443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Systemic overexpression of TNFα-converting enzyme does not lead to enhanced shedding activity in vivo2013
- Author(s)
  Yoda M, Kimura T, Tohmonda T, Morioka H, Matsumoto M, Okada Y, Toyama Y, Horiuchi K
- Journal Title
  
  PLoS One
  
  Volume: 8(1) Issue: 1 Pages: e54412-e54412
- DOI
  10.1371/journal.pone.0054412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592230, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24390358
[Journal Article] Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelialcarcinoma.2013
- Author(s)
  Shunsuke Yoshimine, Eiji Kikuchi, Takeo Kosaka, Shuji Mikami, Akira Miyajima, Yasunori Okada, Mototsugu Oya.
- Journal Title
  
  British Journal of Cancer (2013)
  
  Volume: 108 Issue: 11 Pages: 1-9
- DOI
  10.1038/bjc.2013.216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791784, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24890230
[Journal Article] KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization.2013
- Author(s)
  Yoshida H., Nagaoka A., Kusaka-Kikushima A., Tobiishi M., Kawabata K., Sayo T., Sakai S., Sugiyama Y., Enomoto H., Okada Y. and Inoue S.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 110 Issue: 14 Pages: 5612-5617
- DOI
  10.1073/pnas.1215432110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones2013
- Author(s)
  Saito K, Horiuchi K, Kimura T, Mizuno S, Yoda M, Morioka H, Akiyama H, Threadgill D, Okada Y, Toyama Y, Sato K
- Journal Title
  
  PLoS One
  
  Volume: 8(1) Issue: 1 Pages: e54853-e54853
- DOI
  10.1371/journal.pone.0054853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592230, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24390358
[Journal Article] Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization.2013
- Author(s)
  Yoshida H., Nagaoka A., Nakamura S., Okada Y. and Inoue S.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 3 Issue: 1 Pages: 352-356
- DOI
  10.1016/j.fob.2013.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] HMGA2 is a driver of tumor metastasis.2013
- Author(s)
  Morishita A., Zaidi M. R., Mitoro A., Sankarasharma D., Szabolcs M., Okada Y., D'Armiento J. and Chada K.
- Journal Title
  
  Cancer Res
  
  Volume: 73 Issue: 14 Pages: 4289-4299
- DOI
  10.1158/0008-5472.can-12-3848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis.2013
- Author(s)
  Nkyimbeng T., Ruppert C., Shiomi T., Dahal B.K., Lang G., Seeger W., Okada Y., D´Armiento J. and Gunther A.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 9 Pages: e73279-e73279
- DOI
  10.1371/journal.pone.0073279
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Src plays a role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells.2013
- Author(s)
  Abe H., Mochizuki S., Ohara K., Ueno M., Ochiai H., Kitagawa Y., Hino O., Sato H. and Okada Y.
- Journal Title
  
  Am J Pathol
  
  Volume: 183 Issue: 5 Pages: 1667-1678
- DOI
  10.1016/j.ajpath.2013.07.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24590490
[Journal Article] Regulatory Role of Dendritic Cells in Post-Infarction Healing and Left Ventricular Remodeling2012
- Author(s)
  Atsushi Anzai, Toshihisa Anzai, Shigenori Nagai, Yuichiro Maekawa, Kotaro Naito, Hidehiro Kaneko, Yasuo Sugano, Toshiyuki Takahashi, Hitoshi Abe, Satsuki Mochizuki, Motoaki Sano, Tsutomu Yoshikawa, Yasunori Okada, Shigeo Koyasu, Satoshi Ogawa, and Keiichi Fukuda
- Journal Title
  
  Circulation
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] ADAM282012
- Author(s)
  Satsuki Mochizuki and Yasunori Okada
- Journal Title
  
  Handbook of Proteolytic Enzymes
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] Soluble Vascular Adhesion Protein-1 Accumulates in Proliferative Diabetic Retinopathy.2012
- Author(s)
  Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S.
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: 53 Issue: 7 Pages: 4055-62
- DOI
  10.1167/iovs.12-9857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592588, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24590490, KAKENHI-PROJECT-24592647
[Journal Article] Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha2012
- Author(s)
  Nakayama M., Niki Y., Kawasaki T., Takeda Y., Horiuchi K., Sasaki A., Okada Y., Umezawa K., Ikegami H., Toyama Y. and Miyamoto T.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 14 Issue: 3
- DOI
  10.1186/ar3850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24390359, KAKENHI-PROJECT-24592280
[Journal Article] High-mobility group box 1 protein blockade suppresses development of abdominal aortic aneurysm2012
- Author(s)
  Kohno T., Anzai T., Kaneko H., Sugano Y., Shimizu H., Shimoda M., Miyasho T., Okamoto M., Yokota H., Yamada S., Yoshikawa T., Okada Y., Yozu R., Ogawa S. and Fukuda K
- Journal Title
  
  J Cardiol
  
  Volume: 59 Issue: 3 Pages: 299-306
- DOI
  10.1016/j.jjcc.2012.01.007
- NAID
  10031187749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Effect of ADAM28 on Carcinoma Cell Metastasis by Cleavage of von Willebrand Factor2012
- Author(s)
  Satsuki Mochizuki, Kenji Soejima, Masayuki Shimoda, Hitoshi Abe, Aya Sasaki, Hirotaka James Okano, Hideyuki Okano, Yasunori Okada
- Journal Title
  
  J. Natl. Cancer Inst
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor2012
- Author(s)
  Mochizuki S., Soejima K., Shimoda M., Abe H., Sasaki A., Okano H. J., Okano H. and Okada Y
- Journal Title
  
  J. Natl. Cancer Inst
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Regulation of monocyte chemoattractant protein-1 through angiotensin II type 1receptor in prostate cancer2012
- Author(s)
  Shirotake S, Miyajima A, Kosaka T, Tanaka N, Kikuchi E, Mikami S, Okada Y, Oya M
- Journal Title
  
  Am J Pathol.
  
  Volume: 180(3) Issue: 3 Pages: 1008-16
- DOI
  10.1016/j.ajpath.2011.11.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591777, KAKENHI-PROJECT-23791785, KAKENHI-PROJECT-24249022
[Journal Article] Regulatory Role of Dendritic Cells in Post-Infarction Healing and Left Ventricular Remodeling2012
- Author(s)
  Anzai A, Fukuda K, et al
- Journal Title
  
  Circulation
  
  Volume: 125(10) Issue: 10 Pages: 1234-1245
- DOI
  10.1161/circulationaha.111.052126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249051, KAKENHI-PROJECT-23390217, KAKENHI-PROJECT-23790875, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24590490
[Journal Article] ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-α2012
- Author(s)
  Jowett J.B.M., Okada Y., Leedman P.J., Curran J.E., Johnson M.P., Moses E.K., Goring H.H.H., Mochizuki S., Blangero J., Stone L., Allen H., Mitchell C. and Matthews V.B
- Journal Title
  
  Immunol Cell Biol
  
  Volume: 90 Issue: 10 Pages: 966-973
- DOI
  10.1038/icb.2012.44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24590490
[Journal Article] Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection2012
- Author(s)
  Kurihara T., Shimizu-Hirota R., Shimoda M., Adachi T., Shimizu H., Weiss S. J., Itoh H., Hori S., Aikawa N. and Okada Y
- Journal Title
  
  Circulation
  
  Volume: 126 Issue: 25 Pages: 3070-3080
- DOI
  10.1161/circulationaha.112.097097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Effect of ADAM28 on Carcinoma Cell Metastasis by Cleavage of von Willebrand Factor2012
- Author(s)
  Satsuki Mochizuki
- Journal Title
  
  Journal of the National Cancer Institute
  
  Volume: 104(In press) Issue: 12 Pages: 906-922
- DOI
  10.1093/jnci/djs232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24590490
[Journal Article] Expression of Snail and Slug in renal cell carcinoma : E-cadherin repressor Snail is associated with cancer invasion and prognosis2011
- Author(s)
  Mikami S., Katsube K., Oya M., Ishida M., Kosaka T., Mizuno R., Mukai M. and Okada Y
- Journal Title
  
  Lab. Invest
  
  Volume: 91 Pages: 1443-1458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor 165-promoted chondrocyte migration2011
- Author(s)
  Masashi Okubo, Tokuhiro Kimura, Yoshinari Fujita, Satsuki Mochisuki, Yasuo Niki, Enomoto H, Yasunori Suda, Yoshiaki T and Yasunori Okada
- Journal Title
  
  Arthritis Rheum
  
  Volume: 63 Pages: 3000-3009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor_(165)-promoted chondrocyte migration : an implication for chondrocyte cloning2011
- Author(s)
  Okubo M., Kimura T., Fujita Y., Mochizuki S., Niki Y., Enomoto H., Suda Y., Toyama Y. and Okada Y
- Journal Title
  
  Arthr itis Rheum
  
  Volume: 63 Pages: 3000-3009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Expression of Snail arid Slug in renal cell carcinoma : E-cadherin repressor Snail is associated with cancer invasion and prognosis2011
- Author(s)
  Mikami S., Katsube K., Oya M., Ishida M., Kosaka T., Mizuno R., Mukai M., Okada Y.
- Journal Title
  
  Lab Invest
  
  Volume: 91 Pages: 1443-1458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm2011
- Author(s)
  Kaneko H., Anzai T., Takahashi T., Kohno T., Shimoda M., Sasaki A., Shimizu H., Nagai T., Maekawa Y., Yoshimura K., Aoki H., Yoshikawa T., Okada Y., Yozu R., Ogawa S., Fukuda K.
- Journal Title
  
  Cardiovasc Res
  
  Volume: 91 Pages: 358-367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Dual functions of cell-autonomous and non cell-autonomous ADAM10 activity in granulopoiesis2011
- Author(s)
  Yoda M., Kimura T., Link D.C., Chiba K., Okada Y., Matsumoto M., Toyama Y., Horiuchi K.
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 6939-6942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development2011
- Author(s)
  Kaneko H., Anzai T., Horiuchi K., Kohno T., Nagai T., Anzai A., Takahashi T., Sasaki A., Shimoda M., Maekawa Y., Shimizu H., Yoshikawa T., Okada Y., Yozu R., Fukuda K.
- Journal Title
  
  Atherosclerosis
  
  Volume: 218 Pages: 470-478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production2011
- Author(s)
  Fukuda H., Mochizuki S., Abe H., Okano H.J., Hara-Miyauchi C., Okano H., Yamaguchi N., Nakayama M., D'Armiento J., Okada Y.
- Journal Title
  
  Brit J Cancer
  
  Volume: 105 Pages: 1615-1624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells2011
- Author(s)
  Shirakabe K., Hattori S., Seiki M., Koyasu S., Okada Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 43154-43163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production2011
- Author(s)
  Fukuda H., Mochizuki S., Abe H., Okano H. J., Hara-Miyauchi C., Okano H., Yamaguchi N., Nakayama M., D' Armiento J. and Okada Y
- Journal Title
  
  Br J Cancer
  
  Volume: 105 Pages: 1615-1624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Tumor necrosis factor-αconverting enzyme is a key mediator of abdominal aortic aneurysm development2011
- Author(s)
  Kaneko H., Anzai T., Horiuchi K., Kohno T., Nagai T., Anzai A., Takahashi T., Sasaki A., Shimoda M., Maekawa Y., Shimizu H., Yoshikawa T., Okada Y., Yozu R. and Fukuda K
- Journal Title
  
  Atherosclerosis
  
  Volume: 218 Pages: 470-478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production2011
- Author(s)
  Hiroki Fukuda, Satsuki Mochizuki, Hitoshi Abe, Hirotaka James Okano, Chikako Hara-Miyauchi, Hideyuki Okano, Noriko Yamaguchi, Mitsuo Nakayama, Jeanine D' Armiento and Yasunori Okada
- Journal Title
  
  Br. J. Cancer
  
  Volume: 105 Pages: 1615-1624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] Regulatory role of dendritic cells in post-infarction healing and left ventricular remodeling2011
- Author(s)
  Anzai A., Anzai T., Nagai S., Maekawa Y., Naito K., Kaneko H., Sugano Y., Takahashi T., Abe H., Mochizuki S., Sano M., Yoshikawa T., Okada Y., Koyasu S., Ogawa S., Fukuda K.
- Journal Title
  
  Circulation
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Resveratrol prevents development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization2011
- Author(s)
  Kaneko H., Anzai T., Morisawa M., Kohno T., Nagai T., Anzai A., Takahashi T., Shimoda M., Sasaki A., Maekawa Y., Yoshimura K., Aoki H., Tsubota K., Yoshikawa T., Okada Y., Ogawa S., Fukuda K.
- Journal Title
  
  Atherosclerosis
  
  Volume: 217 Pages: 350-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts2011
- Author(s)
  Kawakami T., Sameshima T., Hojo H., Koga K., Nakahara Y., Toole B.P., Okada Y., Iwasaki A., Nabeshima K.
- Journal Title
  
  BMC Cancer
  
  Volume: 11 Issue: 1 Pages: 300-300
- DOI
  10.1186/1471-2407-11-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004, KAKENHI-PROJECT-23380065
[Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor_<165>-promoted chondrocyte migration : an implication for chondrocyte cloning2011
- Author(s)
  Okubo M., Kimura T., Fujita Y., Mochizuki S., Niki Y., Enomoto H., Suda Y., Toyama Y., Okada Y.
- Journal Title
  
  Arthritis Rheum
  
  Volume: 63 Pages: 3000-3009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Tumor necross factor-α converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis2011
- Author(s)
  Kaneko H., Anzai T., Horiuchi K., Morimoto K., Anzai A., Nagai T., Sugano Y., Maekawa Y., Itoh H., Yoshikiwa T., Okada Y., Ogawa S., Fukuda K.
- Journal Title
  
  Cirulation J
  
  Volume: 75 Pages: 2482-2490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Tumor necross factor-αconverting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis2011
- Author(s)
  Kaneko H., Anzai T., Horiuchi K., Morimoto K., Anzai A., Nagai T., Sugano Y. Maekawa Y., Itoh H., Yoshikiwa T., Okada Y., Ogawa S. and Fukuda K
- Journal Title
  
  Cirulation J
  
  Volume: 75 Pages: 2482-2490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Connective tissue growth factor is a substrate of ADAM282010
- Author(s)
  Mochizuki, S., Tanaka R., Shimoda M., Onuma J., Fujii Y., Jinno H. and Okada Y
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 402 Pages: 651-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Expression of snail in upper urinary tract urothelial carcinoma : prognostic significance and implications for tumor invasion.2010
- Author(s)
  Kosaka T, Kikuchi E, Mikami S, Miyajima A, Shirotake S, Ishida M, Okada Y, Oya M.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 16 Pages: 5814-5823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage.2010
- Author(s)
  Kimura T., Okada A., Yatabe T., Okubo M., Toyama Y., Noda M., Okada Y.
- Journal Title
  
  Am J Pathol
  
  Volume: 176 Pages: 2858-2867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents.2010
- Author(s)
  Hakuno, D., Kimura, N., Yoshioka, M., Mukai, M., Kimura, T., Okada, Y., Yozu, R., Shukunami, C., Hiraki, Y., Kudo, A., Ogawa, S., Fukuda, K.
- Journal Title
  
  J Clin Invest
  
  Volume: 120 Pages: 2292-2306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage2010
- Author(s)
  Kimura T., Okada A., Yatabe T., Okubo M., Toyama Y., Noda M. and Okada Y
- Journal Title
  
  Am. J. Pathol
  
  Volume: 176 Pages: 2858-2867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] MMPs, ADAMs and ADAMTSs in non-neoplastic diseases.2010
- Author(s)
  Shiomi T., Lemaitre V., D'Armiento J., Okada Y.
- Journal Title
  
  Pathol.Int.
  
  Volume: 60 Pages: 477-496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.2010
- Author(s)
  Stokes A., Joutsa J.T., Ala-aho R., Pitchers M., Pennington C.J., Martin C., Premachandra D.J., Okada Y., Peltonen J., Grenman R., James H.A., Edwards D.R., Kahari V-M
- Journal Title
  
  Clin Cancer Res
  
  Volume: 16 Pages: 2022-2035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Connective tissue growth factor is a substrate of ADAM282010
- Author(s)
  Satsuki Mochizuki, Rena Tanaka, Masayuki Shimoda, Junko Onuma, Yutaka Fujii, Hiromitsu Jinno and Yasunori Okada
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 402 Pages: 651-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] Activation of the Aryl hydrocarbon receptor pathway enhances cancer cell invasion by up-regulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer.2010
- Author(s)
  Ishida M., Mikami S., Kikuchi E., Kosaka T., Miyajima A., Nakagawa K., Mukai M., Okada Y., Oya M.
- Journal Title
  
  Carcinogenesis
  
  Volume: 31 Pages: 287-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Connective tissue growth factor is a substrate of ADAM28.2010
- Author(s)
  Mochizuki, S., Tanaka R., Shimoda M., Onuma J., Fujii Y., Jinno H., Okada Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 402 Pages: 651-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.2010
- Author(s)
  Kuroda H., Mochizuki S., Shimoda M., Chijiiwa M., Kamiya K., Izumi Y., Watanabe M., Horinouchi H., Kawamura M., Kobayashi K., Okada Y.
- Journal Title
  
  Int J Cancer (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers2010
- Author(s)
  Hiroaki Kuroda, Satsuki Mochizuki, Masayuki Shimoda, Miyuki Chijiiwa, Kazunori Kamiya, Yotaro Izumi, Masazumi Watanabe, Hirohisa Horinouchi, Masahumi Kawamura, Koichi Kobayashi and Yasunori Okada
- Journal Title
  
  Int. J. Cancer
  
  Volume: 127 Pages: 1844-1856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.2010
- Author(s)
  Kuroda H., Mochizuki S., Shimoda M., Chijiiwa M., Kamiya K., Izumi Y., Watanabe M., Horinouchi H., Kawamura M., Kobayashi K., Okada Y.
- Journal Title
  
  Int J Cancer
  
  Volume: 127 Pages: 1844-1856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers2010
- Author(s)
  Kuroda H., Mochizuki S., Shimoda M., Chijiiwa M., Kamiya K., Izumi Y., Watanabe M., Horinouchi H., Kawamura M., Kobayashi K. and Okada Y
- Journal Title
  
  Int. J. Cancer
  
  Volume: 127 Pages: 1844-1856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Absence of gelatinase (MMP-9) or collagenase (MMP-13) attenuates adriamycin-induced albuminuria and glomerulosclerosis.2010
- Author(s)
  Sakamaki Y., Sasamura H., Hayashi K., Ishiguro K., Takaishi H., Okada Y., D'Armiento J., Saruta T., Itoh H.
- Journal Title
  
  Nephron Exp Nephrology
  
  Volume: 115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Expression of snail in upper urinary tract urothelial carcinoma : prognostic significance and implications for tumor invasion2010
- Author(s)
  Kosaka T, Kikuchi E, Mikami S, Miyajima A, Shirotake S, Ishida M, Okada Y, Oya M
- Journal Title
  
  Clin Cancer Res
  
  Volume: 16 Pages: 5814-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Production and activation of matrix metalloproteinase-7 (matrilysin-1) in the lungs of patients with idiopathic pulmonary fibrosis.2010
- Author(s)
  Fujishima S., Shiomi T., Yamashita S., Yogo Y., Nakano Y., Inoue T., Nakamura M., Tasaka S., Hasegawa N., Aikawa N., Ishizaka A., Okada Y.
- Journal Title
  
  Arch.Pathol.Lab.Med.
  
  Volume: 134 Pages: 1136-1142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents2010
- Author(s)
  Hakuno, D., Kimura, N., Yoshioka, M., Mukai, M., Kimura, T., Okada, Y., Yozu, R., Shukunami, C., Hiraki, Y., Kudo, A., Ogawa, S. and Fukuda, K
- Journal Title
  
  J. Clin. Invest
  
  Volume: 120 Pages: 2292-2306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 as therapeutic target2009
- Author(s)
  Satsuki Mochizuki and Yasunori Okada
- Journal Title
  
  Curr. Pharm. Design In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] ADAM28 as a target for human cancers.2009
- Author(s)
  Mochizuki S., Okada Y.
- Journal Title
  
  Curr.Pharm.Des. 15
  
  Pages: 2349-2358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013040
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF2009
- Author(s)
  Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y, Blobel CP, and Toyama Y
- Journal Title
  
  J. Immunol
  
  Volume: 182 Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.2009
- Author(s)
  Hikata T, Takaishi H, Takito J, Hakozaki A, Furukawa M, Uchikawa S, Kimura T, Okada Y, Matsumoto M, Yoshimura A, Nishimura A, Reddy S V, Asahara H, Toyama Y.
- Journal Title
  
  Blood 113
  
  Pages: 2202-2212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] MMP-13 plays a role in migration, angiogenesis and contraction in mouse skin wound healing.2009
- Author(s)
  Hattori N., Mochizuki S., Kishi K., Nakajima T., Takaishi H., D'Armiento J., Okada Y.
- Journal Title
  
  Am. J.Pathol 175
  
  Pages: 533-546
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] MMP-13 plays a role in migration, angiogenesis and contraction in mouse skin wound healing.2009
- Author(s)
  Hattori N., Mochizuki S., Kishi K., Nakajima T., Takaishi H., D'Armiento J., Okada Y.
- Journal Title
  
  Am.J.Pathol. 175
  
  Pages: 533-546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 as a target for human cancers2009
- Author(s)
  Mochizuki S. and Okada Y
- Journal Title
  
  Cur r. Pharm. Des
  
  Volume: 15 Pages: 2349-2358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1)in humanosteoarthritic chondrocytes.2009
- Author(s)
  Yatabe T., Mochizuki S., Takizawa M. Chijiiwa M., Okada A., Kimura T., Fujita Y. Matsumoto H., Toyama Y, Okada Y.
- Journal Title
  
  Ann Rheum Dis (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Increased RANKL expression is related to tumor migration and metastasis of renal cell carcinomas2009
- Author(s)
  Mikami S., Katsube K., Oya M., Ishida M., Kosaka T., Mizuno R., Mochizuki S., Ikeda T., Mukai M. and Okada Y.
- Journal Title
  
  J Pathol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013040
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF2009
- Author(s)
  Horiuchi, K, T. Kimura, T. Miyamoto, K. Miyamoto, H. Akiyama, H. Takaishi, H. Morioka, T. Nakamura, Y. Okada, C. P. Blobel and Y. Toyama.
- Journal Title
  
  J Immunol 182
  
  Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes2009
- Author(s)
  Yatabe T., Mochizuki S., Takizawa M., Chijiiwa M., Okada A., Kimura T., Fujita Y., Matsumoto H., Toyama Y. and Okada Y
- Journal Title
  
  Ann. Rheum. Dis
  
  Volume: 68 Pages: 1051-1058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.2009
- Author(s)
  Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y. Blobel CP, Toyama Y
- Journal Title
  
  J Immunol 182
  
  Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] MMP-13 plays a role in migration, angiogenesis and contraction in mouse skin wound healing2009
- Author(s)
  Hattori N., Mochizuki S., Kishi K., Nakajima T., Takaishi H., D' Armiento J. and Okada Y
- Journal Title
  
  Am. J. Pathol
  
  Volume: 175 Pages: 533-546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 as a target for human cancers.2009
- Author(s)
  Mochizuki S., Okada Y.
- Journal Title
  
  Curr.Pharm.Des. 15
  
  Pages: 2349-2358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Increased RANKL expression is related to tumor migration and metastasis of renal cell carcinomas2009
- Author(s)
  Mikami S., Katsube K., Oya M., Ishida M., Kosaka T., Mizuno R., Mochizuki S., Ikeda T., Mukai M. and Okada Y
- Journal Title
  
  J. Pathol
  
  Volume: 218 Pages: 530-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes2009
- Author(s)
  Taku Yatabe, Satsuki Mochizuki, Masayuki Takizawa, Miyuki Chijiiwa, Aiko Okada, Tokuhiro Kimura, Yoshinari Fujita, Hideo Matsumoto, Yoshiaki Toyama and Yasunori Okada
- Journal Title
  
  Ann. Rheum. Dis 68
  
  Pages: 1051-1058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] RANKL expression in clear cell renal cel carcinomas andits association with bone metastasis and cancer cell migration2009
- Author(s)
  Shuji Mikami, Ken-ichi Katsube, MototsuguOya, Satsuki Mochizuki, Masayuki Shimoada, Ryuichi Mizuno, Masaru Ishida, Tohru Ikeda, Makio Mukai, and Yasunori Okada
- Journal Title
  
  J. Urology (In press)
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] ADAM12 (Meltrin α) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor-binding protein-5 in osteoarthritic cartilage2008
- Author(s)
  Okada A., Mochizuki S., Yatabe T., Kimura T., Shiomi T., Fujita Y., Matsumoto H., Sehara-Fujisawa A., Iwamoto Y. and Okada Y
- Journal Title
  
  Arthritis Rheum
  
  Volume: 58 Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Purification of matrix metalloproteinases by column chromatography.2008
- Author(s)
  Imai, K., Okada Y.
- Journal Title
  
  Nat Protoc 3
  
  Pages: 1111-1124
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Brain-specific expression of vascular endothelial growth factor 146 correlates with the blood-brain barrier induction in quail embryos2008
- Author(s)
  Ikeda E., Kodama T. Okada Y.
- Journal Title
  
  Dev. Neurosci. 30
  
  Pages: 31-339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis.2008
- Author(s)
  Kimura N., Shukunami C, Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G., Shin'oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. And Fukuda K.
- Journal Title
  
  Circulation 118
  
  Pages: 1737-1747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Expression of heparanase in renal cell carcinomas: Implications for tumor invasion and progression.2008
- Author(s)
  Mikami S., Oya M., Shimoda M., Mizuno R., Ishida M., Kosaka T., Mukai M., Nakajima M. Okada Y.
- Journal Title
  
  Clin. Cancer Res. 14
  
  Pages: 6055-6061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM-12(meltrin-α)is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding Protein 5 in osteoarthritic cartilage2008
- Author(s)
  岡田愛子(望月早月:2番目/10名)
- Journal Title
  
  Arthritis&Rhumatsm 58
  
  Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis2008
- Author(s)
  Kimura N., Shukunami C., Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G., Shin' oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. and Fukuda K
- Journal Title
  
  Circulation
  
  Volume: 118 Pages: 1737-1747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes.2008
- Author(s)
  Takizawa M., Yatabe T., Okada A., Chijiiwa M., Mochizuki S., Ghosh P., Okada Y.
- Journal Title
  
  FEBS Lett 582
  
  Pages: 2945-2949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aagrecanase-1) in osteoarthritic chondrocyte2008
- Author(s)
  Masayuki Takizawa, Taku Yatabe, Aiko Okada, Miyuki Chijiiwa, Satsuki Mochizuki, Peter Ghosh and Yasunori Okada
- Journal Title
  
  FEBS Lett 582
  
  Pages: 2945-2949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] ADAM12 (Meltrin A) is involved in chondrocyte proliferation via cleavageofinsulin-like growth factor-binding protein-5 in osteoarthritic cartilage.2008
- Author(s)
  Okada A., Mochizuki S., Yatabe T., Kinrnra T., Shiomi T., Fujita Y., Matsumoto H., Sehara-Fujisawa A., Iwamoto Y. and Okada Y.
- Journal Title
  
  Arthritis Rheum 58
  
  Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Purification of matrix metalloproteinases by column chromatography2008
- Author(s)
  Imai, K. and Okada Y
- Journal Title
  
  Nat. Protoc
  
  Volume: 3 Pages: 1111-1124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM12 (Meltrin a) is involved in chondrocyte proliferation viacleavage of insulin-like growth factor-binding protein-5 in osteoarthriticcartilage.2008
- Author(s)
  Okada A., Mochizuki S., Yatabe T., Kimura T., Shiomi T., Fujita Y., Matsumoto H., Sehara-Fujisawa A., Iwamoto Y., Okada Y.
- Journal Title
  
  Arthritis Rheum 58
  
  Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM-12 (meltrin-α) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage2008
- Author(s)
  Aiko Okada, Satsuki Mochizuki, Taku Yatabe, Tokuhiro Kimura, Takayuki Shiomi, Yoshinari Fujita, Hideo Matsumoto, Atsuko Sehara-Fujisawa, Yukihide Iwamoto, Yasunori Okada
- Journal Title
  
  Arthritis Rhum 58
  
  Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes2008
- Author(s)
  Takizawa M., Yatabe T., Okada A., Chijiiwa M., Mochizuki S., Ghosh P. and Okada Y
- Journal Title
  
  FEBS Lett
  
  Volume: 582 Pages: 2945-2949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Expression of heparanase in renal cell carcinomas : Implications for tumor invasion and progression2008
- Author(s)
  Mikami S., Oya M., Shimoda M., Mizuno R., Ishida M., Kosaka T., Mukai M., Nakajima M. and Okada Y.
- Journal Title
  
  Clin Cancer Res 14
  
  Pages: 6055-6061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013040
[Journal Article] Purification of matrix metalloproteinases by column chromatography.2008
- Author(s)
  Imai, K. and Okada Y.
- Journal Title
  
  Nat Protoc. (in press)
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteninase activation are associated with the rupture of the chordae tendineae cordis.2008
- Author(s)
  Kimura N., Shukunami C, Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G, Shin'oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. Fukuda K.
- Journal Title
  
  Circulation 118
  
  Pages: 1737-1747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Hypoxia disturbs the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.2007
- Author(s)
  Koto T., Takubo K., Ishida S., Shinoda H., Inoue M., Tsubota K., Okada Y. and Ikeda E.
- Journal Title
  
  Am. J. Pathol. 170
  
  Pages: 1389-1397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] ADAMs in cancer cell proliferation and progression2007
- Author(s)
  Mochizuki S., Okada Y.
- Journal Title
  
  Cancer Sci. (In press)
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] ADAMs in cancer cell proliferation and progression2007
- Author(s)
  Mochizuki S., Okada Y.
- Journal Title
  
  Cancer Sci. (In press)
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells2007
- Author(s)
  Shimoda M., Hashimoto G., Mochizuki S., Ikeda E., Nagai N., Ishida S. and Okada Y
- Journal Title
  
  J. Biol. Chem
  
  Volume: 282 Pages: 25864-25874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Joint diseases and matrix metalloproteinases : A role for MMP-13.2007
- Author(s)
  Takaishi H, Kimura T, Dalal S, Okada Y, D'Armiento J.
- Journal Title
  
  Cur. Pharma. Biotechonol. (In press)
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Predominant expression of 0LIG2 over ID2 is a useful predictive indexof chemosensitive gliomas.2007
- Author(s)
  Mikami S., Hirose Y., YoshidaK., Kawase T., Ohnishi A., Nagashima K., Okada Y. and IkedaE.
- Journal Title
  
  Virchows Arch 450
  
  Pages: 575-584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Cutting Edge : TNF-α-Converting Enzyme (TACE/ADAM17) Inactivation in Mouse Myeloid Cells Prevents Lethality from Endotoxin Shock2007
- Author(s)
  Horiuchi, K., T. Kimura, T. Miyamoto, H. Takaishi, Y. Okada, Y. Toyama, and C. P. Blobel
- Journal Title
  
  J Immunol 179
  
  Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] Proteinases and matrix degradation.2007
- Author(s)
  Okada Y.
- Journal Title
  
  Kelley's Textbook of Rheumatology. Ed. by Harris E. D., Jr., Budd R. C., Ruddy S., Genovese M.C., Firestein G S. and Sargent J. S. 8th edition, Elsevier Saunders. Philadelphia (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Serum levels of matrix metalloproteinase-3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis2007
- Author(s)
  Kobayashi A., Okazaki S., Enomoto H., Shiomi T., Obata K. and Okada Y
- Journal Title
  
  Arch. Pathol. Lab. Med
  
  Volume: 131 Pages: 563-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.2007
- Author(s)
  Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, Ikeda E
- Journal Title
  
  Am J Pathol (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590317
[Journal Article] Joint diseases and matrix metalloproteinases : A role for MMP-13.2007
- Author(s)
  Takaishi H., Kimura T., Dalai S., Okada Y, D'Armiento J
- Journal Title
  
  Cur. Pharma. Biotechonol. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] ADAMs in cancer cell proliferation and progression.2007
- Author(s)
  Mochizuki S. and Okada Y
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 621-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Serum levels of matrix metalloproteinase-3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis.2007
- Author(s)
  Kobayashi A., Okazaki S., Enomoto H., Shiomi T., Obata K., Okada Y.
- Journal Title
  
  Arch. Pathol. Lab. Med. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells2007
- Author(s)
  Masayuki Shimoda, Gakuji Hashimoto, Satsuki Mochizuki, Eiji Ikeda, Norihiro Nagai, Susumu Ishida and Yasunori Okada
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 25864-25874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] TNF A-converting enzyme (TACE/ADAM17) inactivation in mousemyeloid cells prevents lethality from endotoxin shock.2007
- Author(s)
  Horiuchi K., Kimura T., Miyamoto T., Takaishi H., Okada Y, Toyama Y. and Blobel C.P.
- Journal Title
  
  J. Immunol. 179
  
  Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Serum levels of matrix metalloproteinase-3 (stromelysin 1) for monitoring synovitis rheumatoid arthritis.2007
- Author(s)
  Kobayashi A., Okazaki S., Enomoto EL, Shiomi T., Obata K., Okada Y
- Journal Title
  
  Arch. Pathol. Lab. Med. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Modulation of the microenvironment and adhesion of cancer cells byADAMs (a disintegrin and metalloproteinases).2007
- Author(s)
  Okada Y.
- Journal Title
  
  Verh. Dtsch. Ges. Path. 91
  
  Pages: 29-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] TNFα-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock2007
- Author(s)
  Horiuchi K., Kimura T., Miyamoto T., Takaishi H., Okada Y., Toyama Y. and Blobel C. P
- Journal Title
  
  J. Immunol
  
  Volume: 179 Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAMs in cancer cell proliferation and progression2007
- Author(s)
  Satsuki Mochizuki and Yasunori Okada
- Journal Title
  
  Cancer Sci 98
  
  Pages: 621-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] Impaired bone fracture healing in matrix metalloproteinase 13 (MMP-13) deficient mice.2007
- Author(s)
  Kosaki N, Takaishi H, Kamekura S, Kimura T, Okada Y, Minqi L, Amizuka N, Chung U, Nakamura K, Kawaguchi H, Toyama Y, D'Armiento J.
- Journal Title
  
  Bichem. Biophys. Res. Commun (In press)
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Joint diseases and matrix metalloproteinases : A role for MMP-132007
- Author(s)
  Takaishi H., Kimura T., Dalal S., Okada Y., D'Armiento J.
- Journal Title
  
  Cur. Pharma. Biotechonol. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells.2007
- Author(s)
  Shimoda M., Hashimoto G, Mochizuki S., Dceda E., Nagai N., Ishida S. and Okada Y.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 25864-25874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells.2007
- Author(s)
  Shimoda M., Hashimoto G., Mochizuki S., Ikeda E., Nagai N., Ishida S., Okada Y.
- Journal Title
  
  J.Biol. Chem. 282
  
  Pages: 25864-25874
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Joint diseases and matrix metalloproteinases: A role for MMP-13.2007
- Author(s)
  Takaishi H., Kimura T, Dalal S., Okada Y. and D'Anniento J.
- Journal Title
  
  Curr. Phann. Biotechnol. 9
  
  Pages: 47-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] ADAMs in cancer cell proliferation and progression2007
- Author(s)
  Mochizuki S. and Okada Y
- Journal Title
  
  Cancer Sci
  
  Volume: 98 Pages: 621-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Impaired bone fracture healing in matrix metalloproteinase 13 (MMP-13) deficient mice.2007
- Author(s)
  Kosaki N., Takaishi H, Kamekura S., Kimura.T., Okada Y., Minqi L., Amizuka N., Chung U., Nakamura.K., Kawaguchi H., Toyama Y., D'Armiento J.
- Journal Title
  
  Bichem. Biophys. Res. Commun (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Serum levels of matrix metalloproteinase-3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis.2007
- Author(s)
  Kobayashi A, Okazaki S, Enomoto H, Shiomi T, Obata K, Okada Y.
- Journal Title
  
  Arch. Pathol. Lab. Med. (In press)
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Hypoxia disturbs the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells2007
- Author(s)
  Koto T., Takubo K., Ishida S., Shimoda H., Inoue M., Tsubota K., Okada Y., Ikeda E.
- Journal Title
  
  Am. J. Pathol. (In press)
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Bone growth retardation in mouse embryos expressing humancollagenase 1.2007
- Author(s)
  Imai K., Dalai S.S., Hambor J., Mitchell p., Okada Y., Horton W.C. and D'Armiento J.
- Journal Title
  
  Am. J. Physiol. Cell Physiol. 293
  
  Pages: 1209-1215
- NAID
  10012785975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Impaired bone fracture healing in matrix metalloproteinase 13 (MMP-13) deficient mice.2007
- Author(s)
  Kosaki N., Takaishi H., Kamekura S., Kimura T., Okada Y, Minqi L., Amizuka N., Chung U., Nakamura K., Kawaguchi H., Toyama Y, D'Armiento J
- Journal Title
  
  Bichem. Biophys. Res. Commun. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to 。dothelial cells.2007
- Author(s)
  Shimoda M., Hashimoto G, Mochizuki S., Dceda E., Nagai N., Is hida S. and Okada Y.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 25864-25874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Stroma-derived matrix metalloproteinase (MMP)-2 promotes membranetype 1-MMP-dependent tumor growth in mice.2007
- Author(s)
  TaniWakiK., Fukamachi H., Ko moriK., Ohtake Y., Nonaka T., Sakamoto T., Shiomi X, OkadaY., Itoh T., Itohara S., Seiki M.and Yana I.
- Journal Title
  
  Cancer Res. 67
  
  Pages: 4311-4319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Chondromodulin-1 maintain cardiac valvular function by preventing angiogenesis2006
- Author(s)
  Yoshioka M., Yuasa S., Matsumura K., Shiomi T., Shukunami C., Okada Y., Mukai M., Shin H., Yozu R., Sata M., Ogawa S., Hiraki Y., Fukuda K.
- Journal Title
  
  Nat. Med. 12
  
  Pages: 1151-1159
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] ADAM28 is overexpressed in human breast carcinomas : Implications for carcinoma cell proliferation through degradation of insulin-like growth factor binding protein-32006
- Author(s)
  Mitsui Y., Mochizuki S., Kodama T., Shimoda M., Ohtsuka T., Shiomi T., Chijiiwa M., Ikeda T., Kitajima M., Okada Y.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 9913-9920
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis.2006
- Author(s)
  Ohtsuka T., Shiomi T., Shimoda M., Kodama T., Amour A., Murphy G., Ohuchi E., Kobayashi K., Okada Y.
- Journal Title
  
  Int.J.Cancer 118
  
  Pages: 263-273
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Chondromodulin-I maintain cardiac valvular function by preventing angiogenesis.2006
- Author(s)
  Yoshioka M., Yuasa S., Matsumoto K., Shiomi T., Shukunami C, Okada Y, Mukai M., Shin H., Yozu R., Sata M., Ogawa S., Hiraki Y, Fukuda K.
- Journal Title
  
  Nat. Med. 12
  
  Pages: 1151-1159
- NAID
  10017243402
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Tetraspanin CD151 is expressed in osteoarthritic cartilage and is involved in pericellular activation of zymogen of matrix metalloproteinase-7 (matrilysin 1) in osteoarthritic cartilage.2006
- Author(s)
  Fujita Y, Shiomi T, Yanagimoto S, Matsumoto H, Toyama Y, Okada Y
- Journal Title
  
  Arthritis Rheum. 54
  
  Pages: 3233-3243
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Expression of Ets-l and its implications for angiogenesis in human renal cell carcinomas2006
- Author(s)
  Mikami S., Oya M., Mizuno R., Murai M., Mukai M., Okada Y.
- Journal Title
  
  Cancer Sci. 97
  
  Pages: 875-882
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis2006
- Author(s)
  Ohtsuka T., Shiomi T., Shimoda M., Kodama T., Amour A., Murphy G., Ohuchi E., Kobayashi K., Okada Y.
- Journal Title
  
  Int. J. Cancer 118
  
  Pages: 263-273
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Tetraspanin CD151 is expressed in osteoarthritic cartilage and is involved in pericellular activation of zymogen of matrix metalloproteinase-7 (matrilysin 1) in osteoarthritic cartilage.2006
- Author(s)
  Fujita Y., Shiomi T., Yanagimoto S., Matsumoto H., Toyama Y., Okada Y
- Journal Title
  
  Arthritis Rheum. 54
  
  Pages: 3233-3243
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis.2006
- Author(s)
  Imai K, Morikawa M, D'Arminento J, Matsumoto H, Komiya K, Okada Y.:
- Journal Title
  
  Biochem. Biophys. Res. Commun. 345
  
  Pages: 1615-1620
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis.2006
- Author(s)
  Imai K, Morikawa M, D'Arminento J, Matsumoto H, Komiya K, Okada Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 345
  
  Pages: 1615-1620
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Chondromodulin-I maintain cardiac valvular function by preventing angiogenesis.2006
- Author(s)
  Yoshioka M, Yuasa S, Matsumura K, Shiomi T, Shukunami C, Okada Y, Mukai M, Shin H, Yozu R, Sata M, Ogawa S, Hiraki Y, Fukuda K.
- Journal Title
  
  Nat. Med. 12
  
  Pages: 1151-1159
- NAID
  10017243402
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] ADAM28 is overexpressed in human breast carcinomas : Implications for carcinoma cell proliferation through degradation of insulin-like growth factor binding protein-32006
- Author(s)
  Mitsui Y., Mochizuki S., Kodama T., Shimoda M., Ohtsuka T., Shiomi T., Chijiiwa M., Ikeda T., Kitajima M., Okada Y.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 9913-9920
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Tetraspanin CD151 is expressed in osteoarthritic cartilage and is involved in pericellular activation of zymogen of matrix metalloproteinase-7 (matrilysin 1) in osteoarthritic cartilage.2006
- Author(s)
  Fujita Y, Shiomi T., Yanagimoto S., Matsumoto H., Toyama Y., Okada Y.
- Journal Title
  
  Arthritis Rheum. 54
  
  Pages: 3233-3243
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis2006
- Author(s)
  Ohtsuka T., Shiomi T., Shimoda M., Kodama T., Amour A., Murphy G., Ohuchi E., Kobayashi K., Okada Y.
- Journal Title
  
  Int. J. Cancer 118
  
  Pages: 263-273
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Pericellular activation of proMMP-7 (promatrilysin-1) through interaction with CD151.2005
- Author(s)
  Shiomi T., Inoki I., Kataoka F., Ohtsuka T., Hashimoto G., Nemori R., Okada Y.
- Journal Title
  
  Lab.Invest. 85
  
  Pages: 1489-1506
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Human glioblastomas overexpress ADAMTS-5 that degrades brevican.2005
- Author(s)
  Nakada M., Miyamori H., Kita D., Takahashi T., Yamashita J., Sato H., Miura R., Yamaguchi Y., Okada Y.
- Journal Title
  
  Acta Neuropathol. 110
  
  Pages: 239-246
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Development of in situ zymography to selectively localize active matrix metalloproteinase (matrilsn-1).2005
- Author(s)
  Nemori R., Yamamoto M., Arakatsu H., Kataoka F., Hashimoto G., Shiomi T., Okada Y.
- Journal Title
  
  J.Histochem.Cytochem. 53
  
  Pages: 1227-1234
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Expression of ADAM15 in rheumatoid synovium : up-regulation by vascular endothelial growth factor and possible implications for angiogenesis.2005
- Author(s)
  Komiya K., Enomoto H., Inoki I., Okazaki S., Fujita Y., Ikeda E., Ohuchi E., Matsumoto H., Toyama Y., Okada Y.
- Journal Title
  
  Arthritis Res.Ther. 7
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice.2005
- Author(s)
  Matsumura S., Iwanaga S., Mochizuki S., Okamoto H., Ogawa S., Okada Y.
- Journal Title
  
  J.Clin.Invest. 115
  
  Pages: 599-609
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.2004
- Author(s)
  Hashimoto G., Shimoda M., Okada Y.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 32483-32491
- Data Source
  KAKENHI-PROJECT-15659362
[Journal Article] ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of HB-EGF.2004
- Author(s)
  Kodama T., Ikeda E., Okada A., Ohtuska T., Shimoda M., Shiomi T., Yoshida K., Nakada M., Ohuchi E., Okada Y.
- Journal Title
  
  Am J.Pathol. 165
  
  Pages: 1743-1753
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] MMP and ADAM in rheumatoid arthritis.2004
- Author(s)
  Yatabe T., Okada Y.
- Journal Title
  
  Connective Tissue 36
  
  Pages: 223-231
- NAID
  110004014526
- Data Source
  KAKENHI-PROJECT-15659362
[Journal Article] Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.
- Author(s)
  Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, Ikeda E
- Journal Title
  
  Am J Pathol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590317
[Patent] HUMAN ANTIBODY AGAINST AGGRECANASE-TYPE ADAMTS SPECIES FOR THERAPEUTICS OF AGGRECANASE-RELATED DISEASES2016
- Inventor(s)
  Miyakoshi A., Okada Y., et al.
- Industrial Property Rights Holder
  Miyakoshi A., Okada Y., et al.
- Industrial Property Rights Type
  特許
- Filing Date
  2016
- Acquisition Date
  2018
- Data Source
  KAKENHI-PROJECT-16H05454
[Patent] 抗ヒト膜型ADAM28抗体2015
- Inventor(s)
  宮越陽、古城周久、岡田保典、望月早月、下田将之
- Industrial Property Rights Holder
  宮越陽、古城周久、岡田保典、望月早月、下田将之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-045244
- Filing Date
  2015-03-06
- Data Source
  KAKENHI-PROJECT-24249022
[Patent] Human antibody aginast aggrecanase-type ADAMTS species for therapeutics of aggrecanase-related diseases2014
- Inventor(s)
  宮越陽、中村美紀子、古城周久、望月早月、岡田保典
- Industrial Property Rights Holder
  宮越陽、中村美紀子、古城周久、望月早月、岡田保典
- Industrial Property Rights Type
  特許
- Filing Date
  2014-10-14
- Overseas
- Data Source
  KAKENHI-PROJECT-24249022
[Patent] ANTI-ADAM28 ANTIBODIES FOR THERAPEUTICS FOR CARCINOMAS2012
- Inventor(s)
  Yasunoti Okada　他5名
- Industrial Property Rights Holder
  Yasunoti Okada　他5名
- Industrial Property Rights Type
  特許
- Filing Date
  2012-11-19
- Overseas
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] 変形性膝関節症（膝変形性関節症）関節軟骨細胞でのヒアルロン酸分解酵素（HYBIDとTMEM2）の発現調節機構2023
- Author(s)
  塩澤淳、Susana de Vega、良永知穂、根岸義文、百枝雅裕、中村智美、吉田浩之、金子晴香、石島旨章、岡田保典
- Organizer
  第112回日本病理学会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] 食道扁平上皮癌のがん関連線維芽細胞（CAFs）はPeriostinを分泌して癌細胞の増殖・遊走を促進する2023
- Author(s)
  望月早月、石橋勇輔、堀内圭輔、辻本広紀、岸庸二、岡田保典、上野秀樹
- Organizer
  第112回日本病理学会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] EXPRESSION AND REGULATION OF RECENTLY DISCOVERED HYALURONIDASES (HYBID AND TMEM2) IN CONDROCYTES FROM KNEE OA CARTILAGE2023
- Author(s)
  Jun Shiozawa, Susana de Vega, Chiho Yoshinaga, Xang Ji, Yoshifumi Negishi, Masahiro Momoeda, Tomomi Nakamura, Hiroyuki Yoshida, Haruka Kaneko, Muneaki Ishijima, and Yasunori Okada
- Organizer
  2023 OARSI World Congress on Osteoarthritis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] インターロイキン-6による変形性膝関節症由来骨棘細胞のスフェロイド形成抑制作用2023
- Author(s)
  根岸義文, Adili Arepati, Susana de Vega, 百枝雅裕, 金子晴香, Mehmet Zeynel Cilek, 良永知穂, 高藤和輝, 大塚祐多,下田将之, 根岸貴子, 石島旨章, 岡田保典
- Organizer
  第55回日本結合組織学会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] 食道扁平上皮癌でのADAM28発現と抗ADAM28マウスモノクローナル抗体の抗腫瘍効果2023
- Author(s)
  神津慶多, 望月早月, 辻本広紀, 堀口寛之, 石橋勇輔, 藤嶋誠一郎, 永生高広、岸庸二, 岡田保典,上野秀樹
- Organizer
  第55回日本結合組織学会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] ヒアルロン酸分解酵素（HYBIDとTMEM2）の変形性関節症（変形性関節症）関節軟骨細胞での発現、ヒアルロン酸分解活性、発現調節機構2023
- Author(s)
  塩澤淳、Susana de Vega、良永知穂、Xang Ji、根岸義文、百枝雅裕、中村智美、吉田浩之、金子晴香、石島旨章、岡田保典
- Organizer
  第35回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] 関節軟骨破壊に関わる新規ヒアルロン酸分解酵素（HYBIDとTMEM2）の変形性関節症（OA）関節軟骨での発現調節機構2022
- Author(s)
  塩澤淳、Susana de Vega、良永知穂、根岸義文、百枝雅裕、中村智美、吉田浩之、金子晴香、石島旨章、岡田保典
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] ヒアルロン酸分解酵素Hybidのマウス変形性関節症（膝OA）進展における作用解析2022
- Author(s)
  百枝雅裕、スサーナ・デ・ベガ、金子晴香、良永知穂、下田将之、中村智美、遠藤洋子、吉田浩之、金子和夫、石島旨章、岡田保典
- Organizer
  第34回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] がん関連線維芽細胞から分泌されるperiostinはADAM17-TNF-αシグナルの活性化を介して食道扁平上皮癌の細胞増殖・遊走能を促進する2022
- Author(s)
  石橋勇輔、望月早月、堀内圭輔、辻本広紀、岸庸二、岡田保典、上野秀樹
- Organizer
  第27回日本病態プロテアーゼ学会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] 新規ヒアルロニダーゼHYBID及びTMEM2の膝OA関節軟骨組織における機能解析2021
- Author(s)
  塩澤淳、Susana de Vega、良永知穂、中村智美、吉田浩之、金子晴香、金子和夫、石島旨章、岡田保典
- Organizer
  第13回日本関節鏡・膝・スポーツ整形外科学会（JOSKAS）
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] Hybid（hyaluronan-binding protein involved in hyaluronan depolymerization）によるHA分解はマウスでの変形性膝関節症（膝OA）を促進する2021
- Author(s)
  百枝雅裕、スサーナ・デ・ベガ、金子晴香、良永知穂、下田将之、中村朋美、遠藤洋子、吉田浩之、金子和夫、石島旨章、岡田保典
- Organizer
  第53回日本結合組織学会
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] 日本創傷治癒学会における50年の歩みと今後の展望2020
- Author(s)
  岡田保典
- Organizer
  第50回日本創傷治癒学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] 変形性関節症の関節軟骨破壊と再生：概論2020
- Author(s)
  岡田保典
- Organizer
  第64回日本リウマチ学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] 変形性膝関節症（膝OA）の関節軟骨組織におけるヒアルロン酸分解酵素（HYBIDとTMEM2）の発現と発現調節機構2020
- Author(s)
  塩澤淳、Susana de Vega、中村智美、吉田浩之、石島旨章、金子晴香、金子和夫、岡田保典
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] 変形性膝関節症滑膜組織でのHYBID過剰発現は関節液中ヒアルロン酸（HA）分解に関わる。2020
- Author(s)
  塩澤淳、Susana de Vega、Mehmet Z. Cilek、良永知穂、中村智美、笠松慎也、吉田浩之、石島旨章、金子晴香、金子和夫、岡田保典
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] Expression and roles of HYBID (Hyaluronan-binding protein involved in hyaluronan depolymerization), alias CEMIP/KIAA1199, in osteoarthritis2019
- Author(s)
  Yasunori Okada
- Organizer
  The 11th International Conference on Proteoglycans
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] HYBIDは変形性膝関節症滑膜組織で過剰発現し関節液中ヒアルロン酸分解に関与する2019
- Author(s)
  塩澤淳、Susan de Vega、Mehmet Z. Cilek、良永知穂、中村智美、笠松慎也、吉田浩之、金子晴香、石島旨章、金子和夫、岡田保典
- Organizer
  第51回日本結合組織学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] Role of the matricellular protein Fibulin-7 in glioblastoma vascularization2019
- Author(s)
  Susana de Vega, Akihide Kondo, Mario Suzuki, Hajime Arai, Shabierjiang Jiapaer, Hemragul Sabit, Mitsutoshi Nakada, Tomoko Ikeuchi, Muneaki Ishijima, Eri Arikawa-Hirasawa, Yoshihiko Yamada and Yasunori Okada
- Organizer
  The Matricellular Proteins in Tissue Remodeling and Inflammation Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] Fibulin-7 modulates glioblastoma neovascularization via regulation of the Ang1/Ang2-Tie2 system2019
- Author(s)
  Susana de Vega, Mitsutoshi Nakada, and Yasunori Okada
- Organizer
  第78回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] IL-6を介した変形性関節症滑膜線維芽細胞によるHYBID（KIAA1199）過剰発現は関節液中ヒアルロン酸分解に関わる2019
- Author(s)
  塩澤淳、Susana de Vega、Mehmet Z. Cilek、良永知穂、中村智美、笠松慎也、吉田浩之、金子晴香、石島旨章、金子和夫、岡田保典
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] 関節軟骨破壊と再生の基礎研究2019
- Author(s)
  岡田保典
- Organizer
  第32回日本軟骨代謝学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] HYBIDの変形性関節症（OA）関節軟骨での発現亢進とヒアルロン酸（HA）分解における役割2019
- Author(s)
  下田将之、清水英德、望月早月、吉田浩之、塩澤淳、石島旨章、金子和夫、中村雅也、戸山芳昭、岡田保典
- Organizer
  第108回日本病理学総会
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] Understanding the Challenges in Glioblastoma Treatment2019
- Author(s)
  Susana de Vega, Yasunori Okada
- Organizer
  Ⅱ Encuentro de ACE Japon (II Meeting of Spanish Researchers in Japan
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] ヒアルロン酸（HA）の作用と各種疾患におけるHA分解酵素HYBID（Hyaluronan binding protein involved in hyaluronan depolymerization）の役割2018
- Author(s)
  岡田保典
- Organizer
  第50回日本結合組織学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] 変形性関節症の病態解析と診断法開発研究　―現状と今後の展望―2018
- Author(s)
  岡田保典
- Organizer
  第58回関東整形災害外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] 関節軟骨破壊と再生の基礎研究2018
- Author(s)
  岡田保典
- Organizer
  第32回日本軟骨代謝学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] Overexpression of Fibulin-7 Modulates the Ang1-Tie2 System and Contributes to the Aberrant Vasculature in Glioblastoma2018
- Author(s)
  Susana de Vega, Akihide Kondo, Mario Suzuki, Eri Arikawa-Hirasawa, Yasunori Okada
- Organizer
  Matrix Biology Europe
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] Fibulin-7 overproduction contributes to glioma vascularization via interaction with angiopoietin-12018
- Author(s)
  Susana de Vega, Akihide Kondo, Mario Suzuki, Eri Arikawa-Hirasawa and Yasunori Okada
- Organizer
  第107回日本病理学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] HYBIDの変形性関節症関節軟骨での発現とヒアルロン酸分解における役割解析2018
- Author(s)
  清水英徳、下田将之、望月早月、宮前結加、阿部仁、千々岩みゆき、吉田浩之、塩澤淳、石島旨章、金子和夫、金治有彦、中村雅也、戸山芳昭、岡田保典
- Organizer
  第31回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] Analysis of the expression and prospective role of Fibulin-7 in aberrant blood vessel formation in glioblastoma2017
- Author(s)
  Susana de Vega, Akihide Kondo, Mario Suzuki, Eri Arikawa-Hirasawa and Yasunori Okada
- Organizer
  第49回日本結合組織学会学術大会抄録
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] MMP-3: Its role in cartilage destruction and usefulness for diagnosis of RA.2016
- Author(s)
  Yasunori Okada
- Organizer
  Guangdon Medical Association of Rheumatology Annual Academic Conference 2016.
- Place of Presentation
  広州、中国
- Year and Date
  2016-09-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] ヒアルロン酸―アグリカンネットワーク分解を介した軟骨破壊メカニズムと分子標的治療の可能性。2016
- Author(s)
  岡田保典
- Organizer
  第31回日本整形外科基礎学術集会
- Place of Presentation
  博多
- Year and Date
  2016-10-14
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] MMP-3：RA関節軟骨破壊での役割、診断薬としての有用性および今後の課題。2016
- Author(s)
  岡田保典
- Organizer
  第60回日本リウマチ学会総会
- Place of Presentation
  横浜
- Year and Date
  2016-04-21
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] 関節軟骨と滑膜の再生能概論。2016
- Author(s)
  岡田保典
- Organizer
  第31回日本臨床リウマチ学会。
- Place of Presentation
  東京
- Year and Date
  2016-10-29
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] 関節リウマチ関節破壊：現状とこれからの研究・治療への展望2013
- Author(s)
  岡田保典
- Organizer
  第57回日本リウマチ学会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] MMPs in diagnosis and pathogenesis of cardiovascular disease2013
- Author(s)
  Yasunori Okada
- Organizer
  Gordon Research Conference on Matrix Metaloproteinases
- Place of Presentation
  Il Ciocco, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] Selective inhibition of ADAM28 activity by human anti-ADAM28 antibodies suppresses cancer cell proliferation and metastasis.2013
- Author(s)
  Satsuki Mochizuki, Hitoshi Abe, Masyuki Shimoda, Noriko Aramaki-Hattori, Yuka Miyamae, Akira Miyakoshi, Kanehisa Kojoh and Yasunori Okada
- Organizer
  Pan Pacific Connective Tissue Society Symposium
- Place of Presentation
  Hong Kong.
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] ADAM28による癌細胞転移機構とその制御2013
- Author(s)
  望月早月、下田将之、宮越陽、古城周久、岡田保典
- Organizer
  第45回日本結合組織学会学術大会、第60回マトリックス研究会大会合同学術大会
- Place of Presentation
  和歌山
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] Aggrecanase-type ADAMTS species in human osteoarthritic cartilage: Expression and cytokine reactivity in chondrocytes and development of human neutralizing antibodies.2013
- Author(s)
  Aya Shiraishi, Satsuki Mochizuki, Akira Miyakoshi, Kanehisa Kojoh and Yasunori Okada
- Organizer
  Pan Pacific Connective Tissue Society Symposium
- Place of Presentation
  Hong Kong.
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] 関節軟骨の破壊と再生機序2013
- Author(s)
  岡田保典
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  千葉
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] Promotion of cancer cell proliferation and metastasis by ADAM28 and possibility of ADAM28 target therapy2013
- Author(s)
  岡田保典
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] SrcはADAM28の発現に重要な役割を果たす2013
- Author(s)
  望月早月、阿部仁、尾原健太郎、落合大樹、北川雄光、樋野興夫、佐藤博、岡田保典
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] 変形性関節症関節軟骨の破壊と再生におけるメタロプロテアーゼの役割2013
- Author(s)
  岡田保典
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] Selective inhibition of ADAM28 activity by human anti-ADAM28 antibodies suppresses cancer cell proliferation and metastasis2013
- Author(s)
  Satsuki Mochizuki, Hitoshi Abe, Masyuki Shimoda, Noriko Aramaki-Hattori, Yuka Miyamae, Akira Miyakoshi, Kanehisa Kojoh and Yasunori Okada
- Organizer
  9th Pan Pacific Connective Tissue Societies Symposium
- Place of Presentation
  Hong Kong
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] メタロプロテアーゼADAM28の腫瘍細胞における発現機構と悪性化への関与2013
- Author(s)
  望月早月、阿部仁、尾原健太郎、上野万里、落合大樹、北川雄光、樋野興夫、佐藤博、岡田保典
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] ヒトADAM28活性阻害抗体の開発とそれによる癌細胞増殖・転移抑制作用2013
- Author(s)
  望月早月、岡田保典
- Organizer
  第22回日本がん転移学会学術集会・総会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] ADAM28のvon Willebrand factor分解による新規癌細胞転移機構2012
- Author(s)
  望月早月、副島見事、下田将之、阿部仁、佐々木文、岡野ジェイムズ洋尚、岡野英之、岡田保典
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] ADAM28による癌細胞新規転移促進機構2012
- Author(s)
  望月早月、副島見事、下田将之、岡田保典
- Organizer
  第21回日本がん転移学会学術集会・総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] Novel effect of ADAM28 on promotion of carcinoma cell metastasis2012
- Author(s)
  Satsuki Mochizuki, Kenji Soejima, Masayuki Shimoda, and Yasunori Okada
- Organizer
  XXIIIrd FECTS and ISMB Joint Meeting
- Place of Presentation
  Katowice
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] メタロプロテアーゼADAM28によるvon Willebrand factor分解と癌細胞転移機構2012
- Author(s)
  望月早月、副島見事、下田将之、阿部仁、佐々木文、岡野ジェイムズ洋尚、岡野栄之、岡田保典
- Organizer
  第17回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] 病的組織破壊とリモデリングにおけるメタロプロテアーゼ(MMP/ADAM)の作用解析2012
- Author(s)
  岡田保典
- Organizer
  第25回肝類洞壁細胞研究会
- Place of Presentation
  東京・東京ガーデンパレス(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] メタロプロテアーゼ（MMP/ADAM）の機能関節疾患での役割2012
- Author(s)
  岡田保典
- Organizer
  第33回日本炎症・再生医学会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] メタロプロテアーゼによる組織内微小環境因子代謝と癌細胞の増殖・浸潤・転移2012
- Author(s)
  岡田保典
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] メタロプロテアーゼ(MMP/ADAM)を標的としたOA治療:現状と将来2012
- Author(s)
  岡田保典
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  愛知・ウイルあいち(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28 as a possible molecular target for non-small cell lung carcinoma (NSCLC) and breast carcinoma2012
- Author(s)
  Satsuki Mochizuki, Masayuki Shimoda and Yasunori Okada
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] 組織破壊とリモデリングの病理学的研究：統括病理学の時代を迎えて2012
- Author(s)
  岡田保典
- Organizer
  第101回日本病理学会春期総会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] メタロプロテアーゼ(MMP/ADAM)を標的としたOA治療:現状と将来2012
- Author(s)
  岡田保典
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  名古屋
- Year and Date
  2012-03-10
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28による癌細胞転移機構2011
- Author(s)
  望月早月、下田将之、岡田保典
- Organizer
  弟9回日本エラスチン研究会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] MMP/ADAMと癌の増殖・浸潤・転移2011
- Author(s)
  岡田保典
- Organizer
  第100回日本病理学会春期総会
- Place of Presentation
  神奈川・パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] RA滑膜組織におけるアグリカナーゼ型ADAMTS分子の発現と治療戦略2011
- Author(s)
  岡田保典
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  前橋・ベイシア文化ホール(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28 may promote VEGF165-induced angiogenesis in breast carcinomas by the CTGF digestion in the CTGF/VEGF165 complex2011
- Author(s)
  Satsuki Mochizuki, Rena Tanaka, and Yasunori Okada
- Organizer
  Gordon Research Conference on Matrix Metalloproteinase
- Year and Date
  2011-08-10
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] 統括病理学の時代における病理学研究2011
- Author(s)
  岡田保典
- Organizer
  第100回日本病理学会春期総会
- Place of Presentation
  神奈川・パシフィコ横浜(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] CTGF/VEGF165複合体形成とMMP/ADAM分子によるCTGF分解2011
- Author(s)
  岡田保典
- Organizer
  第4回日本CCNファミリー研究会
- Place of Presentation
  岡山・アークホテル岡山(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28 promotes cancer cell proliferation and progression through metabolism of tissue microenvironmental factors2011
- Author(s)
  Yasunori Okada
- Organizer
  Korean Society of Matrix Biology
- Place of Presentation
  韓国・テグ(招待講演)
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 関節疾患における関節軟骨の破壊と再生機構2011
- Author(s)
  岡田保典
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  群馬・ベイシア文化ホール(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production2011
- Author(s)
  Yasunori Okada
- Organizer
  Gordon Research Conference on Matrix Metalloproteinases
- Place of Presentation
  米国,Smithfield, Rhode Island
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 結合組織増殖因子(Connective tissue growth factor, CTGF)は、ADAM28の新規基質である2011
- Author(s)
  望月早月、田中伶奈、岡田保典
- Organizer
  第43回日本結合組織学会学術大会、第58回マトリックス研究会大会合同学術集会
- Place of Presentation
  別府
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] ADAM28のCTGF分解を介したCTGF/VEGF_<165>複合体からのVEGF_<165>の遊離と血管新生促進作用2011
- Author(s)
  望月早月、田中伶奈、岡田保典
- Organizer
  第20回がん転移学会学術集会・総会
- Place of Presentation
  浜松
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] 関節リウマチにおける関節軟骨破壊とメタロプロテアーゼ2011
- Author(s)
  岡田保典
- Organizer
  第55回日本リウマチ学会
- Place of Presentation
  兵庫・神戸ポートピアホテル(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 関節リウマチにおける関節軟骨破壊とメタロプロテアーゼ2011
- Author(s)
  岡田保典
- Organizer
  第55回日本リウマチ学会
- Place of Presentation
  神戸
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 関節軟骨のリモデリング2011
- Author(s)
  木村徳宏、岡田保典
- Organizer
  第57回日本病理学会秋期総会
- Place of Presentation
  東京・日本教育会館(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] Substrates and roles of ADAM28 in human cancers. Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors2010
- Author(s)
  Yasunori Okada
- Organizer
  Invited speaker
- Place of Presentation
  IlCiocco, Italy
- Year and Date
  2010-05-04
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 組織内微小環境因子代謝酵素(MMPs/ADAMs)と関節軟骨の破壊・再生2010
- Author(s)
  岡田保典
- Organizer
  第54回日本リウマチ学会
- Place of Presentation
  神戸(教育講演)
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 癌細胞転移におけるADAM28の役割2010
- Author(s)
  望月早月、下田雅之、岡田保典
- Organizer
  第19回日本がん転移学会学術集会・総会
- Place of Presentation
  金沢
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] Substrates and roles of ADAM28 in human cancers.2010
- Author(s)
  Yasunori Okada
- Organizer
  Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors.
- Place of Presentation
  Il Ciocco, Italy
- Year and Date
  2010-05-04
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28のヒト癌細胞増殖・転移への関与と肺癌診断への応用2010
- Author(s)
  望月早月、岡田保典
- Organizer
  第42回日本結合組織学会学術大会、第57回マトリックス研究会大会合同学術集会
- Place of Presentation
  秋田
- Year and Date
  2010-08-19
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] The role of ADAM28 in cancer cell proliferation and progression2009
- Author(s)
  Satsuki Mochizuki, Masayuki Shimoda, Kenji Soejima, Rena Tanaka, Hirotaka James Okano, Osahiko Tsuji and Yasunori Okada
- Organizer
  8^<th> Pan-Pacific Connective Tissue Society Symposium
- Place of Presentation
  Yokosuka
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] 組織内微小環境因子代謝酵素ADAMの性質とヒト癌組織での役割2009
- Author(s)
  岡田保典
- Organizer
  第20回日本消化器癌発生学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-20013040
[Presentation] ADAM28はVWF誘導性のアポトーシスを抑制し、癌細胞の浸潤・転移促進に働く2009
- Author(s)
  望月早月、下田雅之、岡野洋尚、岡田保典
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] ADAMs in tumor growth and progression.2009
- Author(s)
  Okada Y.
- Organizer
  In Gordon Research Conference on MMPs
- Place of Presentation
  Invited speaker
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAMs in tumor growth and progression2009
- Author(s)
  Yasunori Okada
- Organizer
  In Gordon Research Conference on MMPs
- Place of Presentation
  Les Diablerets, Switzerland
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAMs in tumor growth and progression.2009
- Author(s)
  Yasunori Okada
- Organizer
  Gordon Research Conference on MMPs.
- Place of Presentation
  Les Diablerets, Switzerland.
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28 is involved in the invasion and metastasis of cancer cells by escaping from apoptosis through the cleavage of von Willebrand factor2009
- Author(s)
  Satsuki Mochizuki, Masayuki Shimoda, Kenji Soejima, Hirotaka James Okano, Osahiko Tsuji, and Yasunori Okada
- Organizer
  Gordon Research Conference on Matrix Metalloproteinase
- Place of Presentation
  Les Diablerets
- Year and Date
  2009-09-02
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] ADAM28による癌細胞の増殖・浸潤・転移2008
- Author(s)
  望月早月、下田雅之、副島見事、岡田保典
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会大会合同大会(BMB2008)
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] MMP/ADAMによる組織内微小環境因子代謝2008
- Author(s)
  岡田保典
- Organizer
  第97回日本病理学会
- Place of Presentation
  金沢
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28 may promote cancer cell metastasis by preventing apoptosis through cleavage of von Willebrand factor2008
- Author(s)
  Satsuki Mochizuki, Kenji Soejima, Masayuki Shimoda and Yasunori Okada
- Organizer
  The 6^<th> International Symposium on Cancer Research and Therapy
- Place of Presentation
  Tokyo
- Year and Date
  2008-11-22
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] Analysis of ADAM28-interacting protein that may be related to cancer cell invasion and metastasis : ADAM28 directly binds to and cleaves von Willebrand factor2008
- Author(s)
  Satsuki Mochizuki, Kenji Soejima, Masayuki Shimoda and Yasunori Okada
- Organizer
  FECTS XXIst Meeting
- Place of Presentation
  Marseille
- Year and Date
  2008-07-13
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] 低酸素刺激下の脳血管内皮細胞におけるclaudin-5蛋白質の動態2008
- Author(s)
  池田栄二、皆川卓也、厚東隆志、岡田保典
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19590366
[Presentation] Hypoxia disrupts the blood-brain barrier through modification of claudin-5 molecules in neural vascular endothelial cells2008
- Author(s)
  Minagawa T, Matsuda S, Koto T, Okada Y, Ikeda E.
- Organizer
  15th International Vascular Biology Meeting
- Place of Presentation
  Sydney, Australia
- Year and Date
  2008-06-02
- Data Source
  KAKENHI-PROJECT-19590366
[Presentation] 癌細胞の浸潤・転移に関わるADAM28の結合蛋白質及び新規基質の探索2008
- Author(s)
  望月早月、副島見事、下田将之、岡田保典
- Organizer
  第40回日本結合組織学会学術大会・第55回マトリックス研究会大会合同学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] [Modulation of the microenviromnent and adhesion of cancer cellsbv ADAM fa disintesrin and metalloproteinase)]2007
- Author(s)
  Yasunori Okada
- Organizer
  Gordon conference on Matrix Metalloproteinase
- Place of Presentation
  I1 Ciocco, Italy
- Year and Date
  2007-07-04
- Data Source
  KAKENHI-PROJECT-18013046
[Presentation] ADAM28 binds to and cleaves von Willebrand factor2007
- Author(s)
  Satsuki Mochizuki, Kenji Soejima, Masayuki Shimoda and Yasunori Okada
- Organizer
  Gordon Research Conference on Matrix Metalloproteinase
- Place of Presentation
  Italy
- Year and Date
  2007-06-06
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] [Modulation of the microenviromnent and adhesion of cancer cellsbv ADAM (a disinteerin and metalloproteinase)]2007
- Author(s)
  Yasunori Okada
- Organizer
  第91回ドイツ病理学会総会
- Place of Presentation
  Magdeburg, Germany.Thomas Kirchner
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-18013046
[Presentation] High molecular weight hyaluronan inhibits ADAMTS4 (aggrecanase-1) expression through the CD44 signaling pathway in human osteoarthritic chondrocytes2007
- Author(s)
  Taku Yatabe, Satsuki Mochizuki, Masayuki Takizawa, Miyuki Chijiiwa, Aiko Okada, Tokuhiro Kimura, Yoshinari Fujita, Hideo Matsumoto, Yoshiaki Toyama and Yasunori Okada
- Organizer
  7th Pan Pacific Connective Tissue Societies Symposium
- Place of Presentation
  Cairns
- Year and Date
  2007-10-30
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] CCN1 (Cyr61) is overexpressed in human osteoarthritic cartilage and inhibits ADAMTS4 (aggrecanase-1) activity.
- Author(s)
  Chijiiwa M., Mochizuki S., Kimura T., Abe H., Tanaka Y., Fujii Y., Shimizu H., Enomoto H., Toyama. and Okada Y.
- Organizer
  Matrix Biology Europe 2014.
- Place of Presentation
  Rotterdam, Netherlands
- Year and Date
  2014-06-20 – 2014-06-24
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] 創傷治癒の病理学―二次性創傷治癒におけるMMPの役割―
- Author(s)
  岡田保典
- Organizer
  第16回日本褥瘡学会
- Place of Presentation
  名古屋市、愛知県、名古屋国際会議場
- Year and Date
  2014-08-29 – 2014-08-30
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] OA関節軟骨代謝研究の過去と未来
- Author(s)
  岡田保典
- Organizer
  第28回日本軟骨代謝学会
- Place of Presentation
  文京区、東京都、東京医科歯科大学
- Year and Date
  2015-03-06 – 2015-03-07
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] OA関節軟骨の破壊と再生
- Author(s)
  岡田保典
- Organizer
  第6回日本関節鏡・膝・スポーツ整形外科学会
- Place of Presentation
  広島市、広島県、広島国際会議場
- Year and Date
  2014-07-25 – 2014-07-26
- Invited
- Data Source
  KAKENHI-PROJECT-24249022

1. MOCHIZUKI Satsuki (80365428)

# of Collaborated Projects: 10 results

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43. 平澤恵理 (50245718)

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44. 廣畑聡 (90332791)

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45. 冨田秀太 (10372111)

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46. 渡辺彰吾 (20548341)

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47. 落谷孝広 (60192530)

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48. 西田圭一郎 (80284058)

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49. 大月孝志 (10534802)

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50. 久保田光昭 (30327796)

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51. 梶原由規 (20753023)

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52. 上野秀樹 (90597535)

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53. KIRAN Chada

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54. JEANINE D' armiento

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55. CHADA Kiran

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56. D'ARMIENTO J

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57. ARMIENTO Jeanine D

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58. DARMIENTO Je

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59. CHADA Kirari

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60. EECKHOUT Yve

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61. 菊地栄次

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62. 大家基嗣

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63. 宮島哲

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64. 古賀貴子

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65. 小沢洋子

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66. 依田昌樹

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67. 吉峰俊輔

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68. 福田恵一

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69. 荻野学芳

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70. 平沢恵理

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71. 塩澤淳

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72. 金治有彦

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Okada Yasunori 岡田 保典

OKADA YASUNORI 岡田 保典

OKADA Yasunori 岡田 保典

岡田 保典 オカダ ヤスノリ

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変形性膝関節症発症・進展における骨棘の意義と形成調節機構Principal Investigator

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Expression and functional analysis of hyaluronan-degrading molecule HYBID and its role in tissue destruction and repairPrincipal Investigator

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Pathophysiological study and image analysis of early-stage knee OA by focusing on osteochondrophytesPrincipal Investigator

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Mechanism of articular cartilage destruction in early-stage osteoarthritis and preclinical study on the development of diagnosis and treatment for early-stage osteoarthritis.Principal Investigator

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Pathological study on metalloproteinases in tissue remodeling under pathological conditionsPrincipal Investigator

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ADAM28の癌細胞増殖・浸潤・転移における作用解析Principal Investigator

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Okada Yasunori 岡田保典

OKADA YASUNORI 岡田保典

OKADA Yasunori 岡田保典

岡田保典オカダヤスノリ