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SASAKI Takuya  佐々木 卓也

ORCIDConnect your ORCID iD *help
Researcher Number 40241278
Other IDs
Affiliation (based on the past Project Information) *help 2021 – 2023: 徳島大学, 大学院医歯薬学研究部(医学域), 教授
2016: 徳島大学, 大学院医歯薬学研究部(医学系), 教授
2015: 徳島大学, 大学院医歯薬学研究部, 教授
2012: 徳島大学, ヘルスバイオサイエンス研究部, 教授
2006 – 2012: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 … More
2005 – 2006: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授
2004: 徳島大学, 医学部, 教授
2004: The University of Tokushima, Graduate School Institute of Health Biosciences, Department of Biochemistry, Professor, 大学院・ヘルスバイオサイエンス研究部, 教授
2001 – 2003: The University of Tokushima Graduate School of Medicine, Department of Biochemistry, Professor, 医学研究科, 教授
2000 – 2001: The University of Tokushima School of Medicine Department of Biochemistry Professor, 医学部, 教授
1999: Graduate School of Medicine, Osaka University Associate Professor, 医学系研究科, 助教授
1998: Osaka University Medical School, Associate Professor, 医学部, 助教授
1994 – 1998: 大阪大学, 医学部, 助手
1992 – 1993: 神戸大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / General medical chemistry / General medical chemistry / Pathological medical chemistry / Pathological medical chemistry / Functional biochemistry / Biological Sciences
Except Principal Investigator
General medical chemistry / Pathological medical chemistry / Biological Sciences … More / Basic Section 48040:Medical biochemistry-related / 代謝生物化学 / Biological Sciences / Functional biochemistry / Circulatory organs internal medicine Less
Keywords
Principal Investigator
Rab3A / Rab3 GAP / Rab13 / 低分子量G蛋白質 / JRAB / 神経伝達物質 / Rabphilin-3A / Rabconnectin-3 / タイトジャンクション / Doc2 … More / Rab3 GEP / 小胞輸送 / Rab GDI / 高次神経機能 / Rabファミリー低分子量G蛋白質 / 細胞間接着分子 / Rho / vesicle transport / mSec13 / Rabphilin-11 / Rab11 / Actinin-4 / occludin / 接着分子 / 活性制御蛋白質 / Rab / Rabファミリー / Ca^<2+>センサー / C2様領域 / ERMファミリー / 細胞内小胞輸送 / Rab7 / synaptic plasticity / 微小管 / 神経伝達物質放出 / シナプス小胞輸送 / LTP / Munc13 / long-term potentiation / 構造変化 / Rab3 / ノックアウトマウス / 神経突起形成 / アドヘレンスジャンクション / claudin / Rabconnection-3 / 細胞接着 / 神経伝達 / クローディン / 浸潤・転移 / tight junction / アクチン細胞骨格 / シナプス小胞 / Ca^<2+> / CD44 / RabGDI / 集団的浸潤 / がん浸潤・転移 / Rab12 / cell growth / cell-cell adhesion / neurotransmission / Rab proteins / Signal transduction / Rabファミリー低分子量G蛋自質 / 細胞増殖 / シグナル伝達 / vesicular transport / タイトジャクンション / Claudin / 高次機能 / regulators / グルタミン酸受容体 / Rab3 GFP / シナプス可塑性 / recycling / microtubule / Rab family / cell migration / Rhoファミリー低分子量G蛋白質 / 細胞骨格 / リサイクリング / 細胞運動 / neurotransmitter / けいれん重積 / X染色体性非特異的精神遅滞 / Rab GDIα / 神経筋接合部 / 呼吸不全 / neurotransmitter release / C2 domain / ダイニン / Rabaptin-5 / Muncl3 / KOマウス / 神経回路形成 / 神経回路 / 分子内結合 / PC12細胞 / 細胞内物流システム / シナプス形成 / Rab8 / 細胞間接着 / 組織・器官形成 / 低分子量CTPase / Rabファミリー低分子量GTPase / 可塑性 / scaffold蛋白質 / インテグリン / C2領域 / α-アクチニン / ZO-1 / E-カドヘリン / adherens junction / 機能領域 / アンカリング蛋白質 / Db1 / 細胞膜ラッフリング / アクチンフィラメント / 収縮環 / 細胞質分裂 / 翻訳後修飾 / Cdc42 / Dbl / Rac / Smg GDS / Rho GDI / シナプス / トランスロケーション / シナプトタグミン / アクティブゾーン / rabphilin / regulated secretion / rab3A p25 / smp p25A / 低分子量GTP結合蛋白質 … More
Except Principal Investigator
Rab3A / Rho / Rabphilin-3A / Ras / 神経伝達物質 / 低分子量GTP結合蛋白質 / 低分子量G蛋白質 / Rab / Smg GDS / Rho GDI / REKS / Rab3 GAP / Doc2 / B-Raf / CD44 / BNI1 / MAPキナーゼ / The ERM family / small GTP-binding protein / SNARE / Tomosyn / ERM-CD44系 / アクチン細胞骨格 / rho GDI / smg GDS / rho p21 / ras p21 / 細胞増殖 / 細胞運動 / Frabin / Rabphilin-11 / Rab3 GEP / rabphilin-3A / 翻訳後修飾 / 細胞接着 / 放出反応 / Rabphilin3 / 14-3-3蛋白質 / がん / rabphilin / Disorder領域 / 蛋白質の構造ダイナミクス / アクチン細胞骨格制御 / Small G Protein / ROCK / mDia / SPA2 / SHP-2 / RabGD1 / BNT1 / neurotransmitter release / small G protein / Tomsyn / Cell wall / Screening system / Actin cytoskeleton / Small GTP-binding protein / Budding yeast / スクリーニング法 / 細胞壁 / スクリーニング系 / 出芽酵母 / SMAP / SmgGDS / Rap1 / Small GTP-binding / Rabphi7in-3A / PKC1 / プロフィリン / BNR1 / Gene Therapy / Drug Design / Cell Adhesion / Cell Cycle / Signal Transduction / Information Exchange / Cancer / International Scientific Research / 癌化学療法 / 癌遺伝子治療 / ドラッグデザイン / 情報交換 / 化学発癌 / 癌治療 / ウイルス発癌 / 遺伝子治療 / 薬品設計 / 細胞周期 / シグナル伝達 / 細胞社会学 / 癌 / 海外派遣 / 国際学術 / ゲラニルゲラニル基転移酵素 / ファルネシル基転移酵素 / C末端側ペプチド / プレニル化 / rac p21 / プロテインキナーゼ / シナプス小胞 / 標的蛋白質 / 活性制御蛋白質 / 活性酸素 / 平滑筋 / リン酸化 / ゲラニルゲラニル基 / 細胞内情報伝達機構 / rab3A p25 / smg p25A / CDC25Mm / Transcriptional regulation / Growth control / Cancer cells / Tumor suppressor gene / Tumor promoter / Tumor virus / Oncogene / Information exchange / 研究集会 / 研究室訪問 / 北米 / 研究交流 / がん研究 / 転写調節 / 増殖制御 / がん細胞 / がん抑制遺伝子 / 発がんプロモーター / ウイルス発がん / がん遺伝子 / 研究情報交換 / 高次生体システム / 情報科学 / 疾患 / アウトリーチ / 融合研究 / 病態の理解 / 細胞内ロジスティクス / 画像解析 / オルガネラ / 社会還元 / 成果報告 / 情報発信 / 分子細胞生物学 / ケミカルバイオロジー / 情報科学・工学 / 細胞内輸送 / メンブレントラフィック / Juxtacrine growth / Metalloprotease / Tumor survival / EGFRトランス活性化 / EGFファミリー / SH3蛋白質 / IL-8 / 胃がん / ADAM / metalloprotease / EGF family / repressor / shedding / claudin / cell adhesion molecule / Tight junction / PLZF / Transcriptional repressor / Shedding / HB-EGF / Frabin-Cdc42系 / Nectin-Afadin-Ponsin系 / Rab11 / Gab-1 / Frabin-Cdc42 / Nectin-Afadin / Cadherin-Catenin系 / Nectin-Afadin系 / Necl-5 / Rac / Cdc42 / ネクチン / dynein / 記憶 / Munc13 / Rab GDT / Rob3 GAP / Rab GDI / Ca^<2+>センサー / アクチン / ERM / 細胞骨格 / 浸潤・転移 / 細胞内小胞輸送 / カルモデュリンキナーゼII / rho / ras / GTP結合蛋白質 / 血管平滑筋 / アクティブゾーン / Ca^<2+>チャネル / シナプトタグミン / ral3A p25 / smg p25a / Cキナーゼ / TPA感受性因子 / C3 / HGF Less
  • Research Projects

    (45 results)
  • Research Products

    (50 results)
  • Co-Researchers

    (111 People)
  •  Role of protein conformational dynamics and disorder regions in the regulation of the actin cytoskeleton

    • Principal Investigator
      SAKANE Ayuko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      The University of Tokushima
  •  A novel therapeutic strategy targeted the conformational plasticity of a single molecule for cancer cell invasion and metastasisPrincipal Investigator

    • Principal Investigator
      SASAKI Takuya
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokushima
  •  Function and mode of action of Rab family small G proteins in the formation of neuronal networkPrincipal Investigator

    • Principal Investigator
      SASAKI Takuya
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima
  •  がんの浸潤・転移に関わる細胞間接着分子の小胞輸送の制御機構Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  Administration of the group grant "Intracellular logistics: interdisciplinary approaches to pathophysiology of membrane traffic"

    • Principal Investigator
      YOSHIMORI Tamotsu
    • Project Period (FY)
      2008 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Logistics for the regulation of higher neuronal functionPrincipal Investigator

    • Principal Investigator
      SASAKI Takuya
    • Project Period (FY)
      2008 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  Temporal and spatial regulation of signal transduction by Rab family small G proteinsPrincipal Investigator

    • Principal Investigator
      SASAKI Takuya
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima
  •  多細胞生物の可塑性を支える小胞輸送の制御機構Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      2003 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  Role of the Rab family small G proteins in synaptic and epithelial plasticityPrincipal Investigator

    • Principal Investigator
      SASAKI Takuya
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima
  •  がん細胞の浸潤・転移における小胞輸送の役割の解明Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  膜結合型増殖因子と受容体型チロシンキナーゼを介したがん細胞の浸潤制御機構

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Ehime University
      Osaka University
  •  細胞運動に関わるインテグリンの小胞輸送の制御機構Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima
  •  Role of the Rab family small G proteins in synaptic plasticityPrincipal Investigator

    • Principal Investigator
      SASAKI Takuya
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima
  •  細胞増殖のシグナリング機構

    • Principal Investigator
      高井 義美
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Functions and modes of action of small G proteins in cell adhesion and migrationPrincipal Investigator

    • Principal Investigator
      SASAKI Takuya
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokushima School of Medicine
      Osaka University
  •  記憶形成におけるRab3A系とDoc2系の機能と作用機構

    • Principal Investigator
      白瀧 博通
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Osaka University
  •  Modes of activation and action of Small G proteins

    • Principal Investigator
      TAKAI Yoshimi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University
  •  Molecular mechanism of synatic vesicle exocytosis-Role of vesicle transport in synaptic plasticityPrincipal Investigator

    • Principal Investigator
      SASAKI Takuya
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (B)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima Graduate School of Medicine
      Osaka University
  •  シナプスにおける新しいCa^<2+>センサーの機能と作用機構

    • Principal Investigator
      白瀧 博通
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  Development of the screening system for a new drug which modifies the Rho small GTP-binding protein-mediated signaling pathway

    • Principal Investigator
      TANAKA Kazuma
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
      Osaka University
  •  Function and action of Rab3A in neurotransmitter release

    • Principal Investigator
      SHIRATAKI Hiromichi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University
  •  Functions and modes of action of proteins with C2 domains in Ca^<2+>-dependentPrincipal Investigator

    • Principal Investigator
      SASAKI Takuya
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  シナプスにおける新しいCa^<2+>センサーの機能と作用機構

    • Principal Investigator
      白瀧 博通
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  Ca^<2+>・リン脂質結合領域(C_2)を有する新しい蛋白質の機能と作用機構Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University
  •  神経伝達物質の放出におけるRab3A-Rabphilin-3A系の機能と作用機構

    • Principal Investigator
      白滝 博通
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Osaka University
  •  C_2様領域を持つ新しい蛋白質Rabphilin-3AとDoc2の機能と作用機構Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  シナプスにおける新しいCa^<2+>センサーの機能と作用機構

    • Principal Investigator
      白瀧 博通
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Okazaki National Research Institutes
  •  神経伝達物質の放出機構におけるRab3A低分子量G蛋白質系の機能と作用機構Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  低分子量G蛋白質Rhoの活性化機構と作用機構Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  プレ・ポストシナプスの相互作用における低分子量G蛋白質の役割と作用機構

    • Principal Investigator
      SHIRATAKI Hiromichi
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Okazaki National Research Institutes
  •  細胞質分裂における低分子量G蛋白質Rhoの機能と作用機構Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  細胞の増殖・分化のシグナルの伝達機構

    • Principal Investigator
      高井 義美
    • Project Period (FY)
      1994 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Osaka University
  •  低分子量G蛋白質Rhoの活性化機構と作用機構Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University
  •  Information Exchange on Cancer Research with North American

    • Principal Investigator
      YAMAMOTO Tadashi
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      The University of Tokyo
  •  Signal transduction of Small GTP-binding proteins

    • Principal Investigator
      TAKAI Yoshimi
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University
  •  cDNAs and antibodies for small GTP-binding proteins

    • Principal Investigator
      TAKAI Yoshimi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  細胞内情報伝達系と細胞増殖の制御機構

    • Principal Investigator
      TAKAI Yoshimi
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kobe University
  •  蛋白質の選別輸送における低分子量GTP結合蛋白質の機能と作用機構Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kobe University
  •  血管平滑筋細胞における血管作動物質のシグナル伝達と低分子量GTP結合蛋白質

    • Principal Investigator
      KAWAHARA Yasuhiro
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  rho p21 GTP結合蛋白質による細胞骨格の制御機構とその病態Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kobe University
  •  蛋白質の選別輸送における低分子量GTP結合蛋白質の機能と作用機構Principal Investigator

    • Principal Investigator
      佐々木 卓也
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kobe University
  •  神経伝達物質放出における低分子量GTP結合蛋白質の機能と作用機構

    • Principal Investigator
      貝淵 弘三
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kobe University
  •  Information Exchange on Cancer Research with North American Countries.

    • Principal Investigator
      YAMAGUCHI Nobuo
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Institute of Medical Science, University of Tokyo
  •  signal transduction of small GTP binding proteins

    • Principal Investigator
      TAKAI Yoshimi
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kode University
  •  cDNAs and antibodies for small GTP-binding proteins

    • Principal Investigator
      TAKAI Yoshimi
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      代謝生物化学
    • Research Institution
      Kobe University

All 2023 2022 2021 2016 2015 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book

  • [Book] 生体の科学(Rab3Aと神経可塑性) 61巻5号2010

    • Author(s)
      坂根亜由子, 佐々木卓也
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Book] 細胞工学(RabファミリーSmall Gタンパク質による小胞輸送制御と高次生命機能) 28巻12号2009

    • Author(s)
      坂根亜由子, 佐々木卓也
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Journal Article] Rapid, high-sensitivity detection of biomolecules using dual-comb biosensing2023

    • Author(s)
      Miyamura Shogo、Oe Ryo、Nakahara Takuya、Koresawa Hidenori、Okada Shota、Taue Shuji、Tokizane Yu、Minamikawa Takeo、Yano Taka-Aki、Otsuka Kunihiro、Sakane Ayuko、Sasaki Takuya、Yasutomo Koji、Kajisa Taira、Yasui Takeshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 14541-14541

    • DOI

      10.1038/s41598-023-41436-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K15976, KAKENHI-PROJECT-21K06838
  • [Journal Article] s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons2023

    • Author(s)
      Maruo Tomohiko、Mizutani Kiyohito、Miyata Muneaki、Kuriu Toshihiko、Sakakibara Shotaro、Takahashi Hatena、Kida Daichi、Maesaka Kouki、Sugaya Tsukiko、Sakane Ayuko、Sasaki Takuya、Takai Yoshimi、Mandai Kenji
    • Journal Title

      Journal of Biological Chemistry

      Volume: 299(4) Issue: 4 Pages: 103040-103040

    • DOI

      10.1016/j.jbc.2023.103040

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07057, KAKENHI-PROJECT-20K15793, KAKENHI-PROJECT-21K06177, KAKENHI-PROJECT-21K06838
  • [Journal Article] JRAB/MICAL-L2 undergoes liquid-liquid phase separation to form tubular recycling endosomes2021

    • Author(s)
      Sakane Ayuko、Yano Taka-aki、Uchihashi Takayuki、Horikawa Kazuki、Hara Yusuke、Imoto Issei、Kurisu Shusaku、Yamada Hiroshi、Takei Kohji、Sasaki Takuya
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 551-551

    • DOI

      10.1038/s42003-021-02080-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07084, KAKENHI-PROJECT-18H02894, KAKENHI-PLANNED-18H05415, KAKENHI-PUBLICLY-20H04669, KAKENHI-PUBLICLY-21H00393, KAKENHI-PROJECT-21H01772, KAKENHI-PROJECT-20K08591, KAKENHI-PROJECT-21K06838
  • [Journal Article] Conformational Plasticity of JRAB/MICAL-L2 Provides 'Law and Order'2016

    • Author(s)
      A. Sakane, S. Yoshizawa, M. Nishimura, Y. Tsuchiya, N. Matsushita, K. Miyake, K. Horikawa, I. Imoto, C. Mizuguchi, H. Saito, T. Ueno, S. Matsushita, H. Haga, S. Deguchi, K. Mizuguchi, H.
    • Journal Title

      Molecular Biology of the Cell

      Volume: 27 Issue: 20 Pages: 3095-3108

    • DOI

      10.1091/mbc.e16-05-0332

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05858, KAKENHI-PLANNED-15H05954, KAKENHI-PROJECT-15H03004, KAKENHI-PROJECT-16J01828, KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-26430104, KAKENHI-PROJECT-26460370, KAKENHI-PROJECT-15K15084, KAKENHI-PROJECT-16K12872, KAKENHI-INTERNATIONAL-15K21726, KAKENHI-ORGANIZER-15H05856
  • [Journal Article] Roles of Rab family small G proteins in formation of the apical junctional complex in epithelial cells2015

    • Author(s)
      Sakane, A. and Sasaki, T.
    • Journal Title

      Cell Polarity: Biological Role and Basic Mechanisms

      Volume: 1 Pages: 349-374

    • DOI

      10.1007/978-3-319-14463-4_15

    • ISBN
      9783319144627, 9783319144634
    • Data Source
      KAKENHI-PUBLICLY-25111723, KAKENHI-PROJECT-26460370, KAKENHI-PROJECT-15K15084
  • [Journal Article] Expression of RASSF6 in kidney and the implication of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis in renal proximal tubular epithelial cells2012

    • Author(s)
      Withanage, K., Nakagawa, K., Ikeda, M., Kurihara, H., Kudo, T., Yang, Z., Sakane, A., Sasaki, T. and Hata, Y
    • Journal Title

      J. Biochem

      Volume: 152(1) Issue: 1 Pages: 111-119

    • DOI

      10.1093/jb/mvs056

    • NAID

      10031166119

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004, KAKENHI-PROJECT-21390082, KAKENHI-PROJECT-22790275, KAKENHI-PROJECT-22790293, KAKENHI-PROJECT-23790325, KAKENHI-PROJECT-24591214, KAKENHI-PROJECT-24790285
  • [Journal Article] Rab13 small G protein and Junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial Junctional development2012

    • Author(s)
      Sakane, A., Abdallah, A.A.M., Nakano, K., Honda, K., Ikeda, W., Nishikawa, Y., Matsumoto, M., Matsushita, N., Kitamura. T., and Sasaki, T
    • Journal Title

      J. Biol. Chem

      Volume: 287(51) Issue: 51 Pages: 42455-424680

    • DOI

      10.1074/jbc.m112.383653

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004, KAKENHI-PROJECT-22790931, KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-24790285
  • [Journal Article] Rabl3 regulates neurite outgrowth in PC12 cells through its effector protein2010

    • Author(s)
      Sakane A., Honda K., Sasaki, T.
    • Journal Title

      JRAB/MICAL-L2.Mol.Cell.Biol. 30

      Pages: 1077-1087

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Journal Article] Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain.2010

    • Author(s)
      Tabata K, Matsunaga K, Sakane A, Sasaki T, Noda T, Yoshimori T.
    • Journal Title

      Mol Biol Cell.

      Volume: 21 Pages: 4162-4172

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-20113001
  • [Journal Article] Rubicon and PLEKHMI negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain.2010

    • Author(s)
      Tabata, K.Sasaki, T., et al.(6人中4番目)
    • Journal Title

      Mol.Biol.Cell 21

      Pages: 4162-4173

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Journal Article] Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L22010

    • Author(s)
      Sakane, A., Honda, K. and Sasaki, T
    • Journal Title

      Mol. Cell. Biol

      Volume: 30(4) Issue: 4 Pages: 1077-1087

    • DOI

      10.1128/mcb.01067-09

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004, KAKENHI-PROJECT-21390082, KAKENHI-PROJECT-22790293
  • [Journal Article] Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain2010

    • Author(s)
      Tabata, K., Matsunaga, K., Sakane, A., Sasaki, T., Noda, T. and Yoshimori, T
    • Journal Title

      Mol. Biol. Cell

      Volume: 21(23) Issue: 23 Pages: 4162-4173

    • DOI

      10.1091/mbc.e10-06-0495

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004, KAKENHI-PROJECT-21390082, KAKENHI-PROJECT-22790293
  • [Journal Article] Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain2010

    • Author(s)
      Tabata K, Matsunaga K, Sakane A, Sasaki T, Noda T, Yoshimori T
    • Journal Title

      Mol Biol Cell

      Volume: 21 Pages: 4162-4172

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-20113001
  • [Journal Article] Rab family small G proteins in regulation of epithelial apical junctions.2009

    • Author(s)
      Nishimura, N., Sasaki, T.
    • Journal Title

      Front.Biosci. 14

      Pages: 2115-2129

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Journal Article] Rab family small G proteins in regulation of epithelial apical junctions2009

    • Author(s)
      Nishimura, N. and Sasaki, T.
    • Journal Title

      Front. Biosci

      Volume: 14 Pages: 2115-2129

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/19273188

    • Data Source
      KAKENHI-PROJECT-21390082
  • [Journal Article] Rab family small G proteins in regulation of epithelial apical junctions2009

    • Author(s)
      Nishimura, N. and Sasaki, T
    • Journal Title

      Front. Biosci

      Volume: 14 Pages: 2115-2129

    • Data Source
      KAKENHI-PLANNED-20113004
  • [Journal Article] APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle2009

    • Author(s)
      Szodorai, A., Kuan, Y-H., Hunzelmann, S., Engel, U., Sakane, A., Sasaki, T., Takai Y., Kirsch, J., Muller, U., Beyreuther, K., Brady, S., Morfini, G. and Kins, S
    • Journal Title

      J. Neurosci

      Volume: 29 (46) Issue: 46 Pages: 14534-14544

    • DOI

      10.1523/jneurosci.1546-09.2009

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004, KAKENHI-PROJECT-21390082
  • [Journal Article] APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.2009

    • Author(s)
      Szodorai, A.Sasaki, T., et al.(13人中6番目)
    • Journal Title

      J.Neurosci. 29

      Pages: 14534-14544

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Journal Article] Analysis on the emerging role of Rab3 GTPase-activating protein in Warburg Micro and Martsolf syndrome2008

    • Author(s)
      Sakane, A., Miyoshi, J., Takai, Y. and Sasaki, T
    • Journal Title

      Methods Enzymol

      Volume: 438 Pages: 131-139

    • DOI

      10.1016/s0076-6879(07)38009-9

    • Data Source
      KAKENHI-PLANNED-20113004
  • [Journal Article] Cell-surface biotinylation to study endocytosis and recycling of occludin2008

    • Author(s)
      Nishimura, N. and Sasaki, T
    • Journal Title

      Methods Mol. Biol

      Volume: 440 Pages: 89-96

    • DOI

      10.1007/978-1-59745-178-9_7

    • ISBN
      9781588298652, 9781597451789
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Journal Article] Interaction of Rab3B with microtubule-binding protein Gas8 in NIH 3T3 cells2008

    • Author(s)
      Nishimura, N., Araki, K., Shinahara, W., Nakano, Y., Nishimura, K., Higashio, H. and Sasaki, T
    • Journal Title

      Arch. Biochem. Biophys

      Volume: 474(1) Issue: 1 Pages: 136-142

    • DOI

      10.1016/j.abb.2008.03.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Journal Article] Involvement of actinin-4 in the recruitment of JRAB/MICAL-L2 to cell-cell junctions and the formation of functional tight junctions2008

    • Author(s)
      Nakatsuji, H., Nishimura, N., Yamamura, R., Kanayama, H. and Sasaki, T
    • Journal Title

      Mol. Cell. Biol

      Volume: 28 (10) Issue: 10 Pages: 3324-3335

    • DOI

      10.1128/mcb.00144-08

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Journal Article] Doc2α and Munc13-4 regulate Ca^<2+>-dependent secretory lysosome exocytosis in mast cells2008

    • Author(s)
      Higashio, H., Nishimura, N., Ishizaki, H., Miyoshi, J., Orita, S., Sakane, A. and Sasaki, T
    • Journal Title

      J. Immunol

      Volume: 180 (7) Pages: 4774-4784

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Journal Article] Identification and characterization of JRAB/MICAL-L2, a junctional Rab 13-binding protein2008

    • Author(s)
      Nishimura, N. and Sasaki, T
    • Journal Title

      Methods Enzymol

      Volume: 438 Pages: 141-153

    • DOI

      10.1016/s0076-6879(07)38010-5

    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] The role and significance of JRAB/MICAL-L2-mediated molecular complex formation and dissociation in the regulation of membrane structure and function2022

    • Author(s)
      坂根亜由子、佐々木卓也
    • Organizer
      第45回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06838
  • [Presentation] 動く細胞2012

    • Author(s)
      佐々木卓也, 坂根亜由子
    • Organizer
      ViEW2012 ビジョン技術の実利用ワークショップ
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2012-12-06
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] 細胞接着・運動においてRab13-JRAB系が制御する小胞輸送とアクチン細胞骨格再編成2011

    • Author(s)
      坂根亜由子、佐々木卓也
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-21390082
  • [Presentation] A role of JRAB in epithelial junctional development : The cross-talk between vesicular trafficking and actin cytoskeleton in the submembrane plaque細胞間接着形成過程においてJRABが制御する細胞内小胞輸送とアクチン細胞骨格系の細胞膜直下でのクロストーク機構2011

    • Author(s)
      Ayuko Sakane and Takuya Sasaki
    • Organizer
      第63回日本細胞生物学会大会ミニシンポジウム
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2011-06-28
    • Data Source
      KAKENHI-PROJECT-21390082
  • [Presentation] A role of JRAB in epithelial junctional development: The cross-talk between vesicular trafficking and actin cytoskeleton in the submembrane plaque, 細胞間接着形成過程においてJRAB が制御する細胞内小胞輸送とアクチン細胞骨格系 の細胞膜直下でのクロストーク機構2011

    • Author(s)
      Ayuko Sakane and Takuya Sasaki
    • Organizer
      第63回日本細胞生物学会大会ミニシンポジウム
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2011-06-28
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] 細胞接着・運動において Rab13-JRAB系が制御する小胞輸送とアクチン細胞骨格再編成2011

    • Author(s)
      佐々木卓也, 坂根亜由子
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] Functions of Rab family small G proteins in neurite outgrowth.2010

    • Author(s)
      Takuya Sasaki, et al.
    • Organizer
      第62回日本細胞生物学会大会シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-21390082
  • [Presentation] Role of Rab small G proteins in cellular morphogenesis.2010

    • Author(s)
      Takuya Sasaki, Ayuko Sakane
    • Organizer
      Sapporo International Cancer Symposium
    • Place of Presentation
      Sapporo
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] Functions of Rab family small G proteins in neurite outgrowth.2010

    • Author(s)
      Takuya Sasaki, Ayuko Sakane
    • Organizer
      第62回日本細胞生物学会大会シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] The Rubicon family negatively regulates the endocytic pathway through the interactions with Rab7.2010

    • Author(s)
      Tabata K. Sasaki T., et al.(6人中4番目)
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-19
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] Exocytotic Rab small G proteins regulate neuronal development and plasticity.2010

    • Author(s)
      Takuya Sasaki, Ayuko Sakane
    • Organizer
      BMB2008シンポジウム(第31回日本分 子生物学会年会・第81回日本生化学会大 会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-11
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] The Rubicon family negatively regulates the endocytic pathway through the interactions with Rab7, Rubiconファミリーは Rab7との結合を介してエンドサイトーシス経路を負に制御する2010

    • Author(s)
      Keisuke Tabata, Kohichi Matsunaga, Ayuko Sakane, Takuya Sasaki, Takeshi Noda and Tamotsu Yoshimori
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-05-19
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] Functions of Rab family small G proteins in neurite outgrowth. 神経突起形成における Rabファミリー低分子量G蛋白質の機能2010

    • Author(s)
      Takuya Sasaki and Ayuko Sakane
    • Organizer
      第62回日本細胞生物学会大会シンポジウム
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] he Rubicon family negatively regulates the endocytic pathway through the interactions with Rab7. RubiconファミリーはRab7との結合を介してエンドサイトーシス経路を負に制御する2010

    • Author(s)
      Keisuke Tabata, Kohichi Matsunaga, Ayuko Sakane, Takuya Sasaki, Takeshi Noda and Tamotsu Yoshimori
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-05-19
    • Data Source
      KAKENHI-PROJECT-21390082
  • [Presentation] Role of Rab small G proteins in cellular morphogenesis.2010

    • Author(s)
      Takuya Sasaki, et al.
    • Organizer
      Sapporo International Cancer Symposium 2010
    • Place of Presentation
      札幌市
    • Year and Date
      2010-06-28
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] Role of Rab small G proteins in cellular morphogenesis.2010

    • Author(s)
      Takuya Sasaki, et al.
    • Organizer
      Sapporo International Cancer Symposium 2010
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-28
    • Data Source
      KAKENHI-PROJECT-21390082
  • [Presentation] Functions of Rab family small G proteins in neurite outgrowth.神経突起形成におけるRabファミリー低分子量G蛋白質の機能2010

    • Author(s)
      Takuya Sasaki and Ayuko Sakane
    • Organizer
      第62回日本細胞生物学会大会シンポジウム
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-21390082
  • [Presentation] Functions of Rab family small G proteins in neurite outgrowth.2010

    • Author(s)
      Takuya Sasaki, et al.
    • Organizer
      第62回日本細胞生物学会大会シンポジウム
    • Place of Presentation
      大阪市
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] 高次細胞機能発現におけるエキソサイトーシス系Rabファミリー低分子量G蛋白質の作用機構2008

    • Author(s)
      佐々木卓也
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-06-30
    • Data Source
      KAKENHI-PROJECT-20013031
  • [Presentation] 高次細胞機能発現におけるエキソサイトーシス系Rabファミリー低分子量G蛋白質の作用機構2008

    • Author(s)
      佐々木卓也
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-06-30
    • Data Source
      KAKENHI-PLANNED-20113004
  • [Presentation] Functions of Rab family small G proteins in regulated exocytosis.2007

    • Author(s)
      Takuya Sasaki
    • Organizer
      International Symposium on Membrane Traffic
    • Place of Presentation
      Awaji
    • Year and Date
      2007-11-29
    • Data Source
      KAKENHI-PROJECT-15079207
  • [Presentation] Functions of Rab family small G proteins in regulated exocytosis.2007

    • Author(s)
      Takuya Sasaki
    • Organizer
      International Symposium on Membrane Traffic
    • Place of Presentation
      Awaji
    • Year and Date
      2007-11-29
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390089
  • [Presentation] Functions of Rab family small G proteins in regulated exocytosis2007

    • Author(s)
      Sasaki, T., et. al.
    • Organizer
      International Symposium on Membrane Traffic
    • Place of Presentation
      in Awaji
    • Year and Date
      2007-11-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390089
  • [Presentation] Functions of Rab family small G proteins in regulated exocytosis2007

    • Author(s)
      Takuya Sasaki
    • Organizer
      International Symposium on Membrane Traffic
    • Place of Presentation
      Awaji
    • Year and Date
      2007-09-29
    • Data Source
      KAKENHI-PROJECT-18390089
  • 1.  TAKAI Yoshimi (60093514)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 0 results
  • 2.  SHIRATAKI Hiromichi (90249962)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 3.  TANAKA Kazuma (60188290)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
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  • 111.  栗生 俊彦
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