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Inui Ken-ichi  乾 賢一

… Alternative Names

INUI Kenichi  乾 賢一

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Researcher Number 70034030
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-1224-7310
External Links
Affiliation (Current) 2025: 京都大学, 医学研究科, 名誉教授
Affiliation (based on the past Project Information) *help 2017: 京都大学, 薬学部, 名誉教授
2010: Kyoto University, 医学研究科, 名誉教授
2009: 京都大学, 大学院・医学研究科, 教授
1995 – 2009: Kyoto University, Department of Pharmacy, Professor, 医学研究科, 教授
1999: 京都大学, 大学院・医学研究科, 教授 … More
1998: 京都大学, 医学部・附属病院, 教授
1996 – 1997: 京都大学, 大学院・医学研究科, 教授
1994 – 1997: 京都大学, 医学部, 教授
1993: 東京医歯大, 医学部, 教授
1990 – 1993: Tokyo Medical and Dental University, School of Medicine, Department of Hospital Pharmacy, Professor, 医学部, 教授
1990: 東京医科歯科大学, 薬剤部, 教授
1987 – 1989: Kyoto Univ., Faculty of Med., Associate Professor, 医学部, 助教授
1986: 京大, 医学部, 講師
1986: Kyoto Univ., Sch. of Med., Lecturer, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
応用薬理学・医療系薬学 / Biological pharmacy / 医薬分子機能学 / Medical pharmacy / Applied pharmacology / Biological Sciences / Physical pharmacy
Except Principal Investigator
Biological pharmacy / 応用薬理学・医療系薬学 / Biological Sciences … More / Medical sociology / 生物・生体工学 / 医学一般 / Urology / General physiology Less
Keywords
Principal Investigator
尿細管分泌 / 有機カチオン / ペプチドトランスポータ / 有機アニオントランスポータ / 腸管吸収 / ジペプチド / 有機アニオン / 薬物輸送 / 有機カチオントランスポータ / 培養上皮細胞 … More / 経細胞輸送 / 輸送担体 / 刷子縁膜 / 薬物トランスポータ / プロトン共役輸送 / 小腸上皮細胞 / β-ラクタム抗生物質 / Organic Cation / Intestinal Absorption / 腎臓 / 薬物動態 / トランスポータ / 薬物送達システム / LLC-PK_1 / シスプラチン / 卵母細胞 / 腎尿細管上皮細胞 / 薬物相互作用 / テトラエチルアンモニウム / P-糖タンパク質 / Organic cation transporter / Organic anion transporter / Drug transport / Peptide transporter / Caco-2 / クローニング / cDNAクローニング / Proton-Coupled Transport / Dipeptide / Transcellular Transport / Cultured Epithelial Cell / Intestinal Epithelial Cell / 吸収・分泌 / Tubular Secretion / セファロスポリン系抗生物質 / βーラクタム抗生物質 / 薬学 / 遺伝子多型 / 発現プロファイル / カルシニューリン / トランスポートソーム / 発現調節 / 薬物体内動態 / タクロリムス / 免疫抑制剤 / P-糖蛋白質 / ヒスチジン残基 / 頂側膜酵素 / DNA断片化 / 細胞障害 / ネクローシス / アポトーシス / 薬剤性腎障害 / H^+-Coupled Transport / beta-Lactam Antibiotic / Active Transport / Absorption and Secretion / Brush Border Membrane / Renal Tubular Epithelial Cell / 吸収分泌 / 能動輸送 / Cultured Renal Epithelial Cell / Renal Plasma Membranes / Cyclic GMP / Receptor Binding / Vasopressin / Atrial Natriuretic Polypeptide (ANP) / 尿細管上皮細胞 / 利尿作用 / ペプチドホルモン受容体 / 培養腎上皮細胞 / 尿細管細胞膜 / サイクリックGMP / 受容体結合 / バソプレッイン / 心房性ナトリウム利尿ポリペプチド / cyclosoorine / tacrolimus / calcineurin / liver transplantation / transporter / drug metabolizing enzyme / absorptive barrier / immunosuppressant / 肝臓移植治療 / シクロスポリン / 肝移植治療 / 薬物代謝酵素 / 吸収障壁 / Organic ion / Renal excretion / Detoxification system / Expression profile / Genetic polymorphism / Interindividual differences / Personalized pharmacotherapy / Drug transporter / 遺伝子発現 / 腎疾患 / ペプチド類似薬物 / カチオン性薬物 / アニオン性薬物 / オーダーメイド薬物療法 / 有機イオン / 腎排泄 / 解毒システム / 固体間変動 / テーラーメイド薬物療法 / Drug interaction / Tubular secretion / Excretion / Kidney / 3級アミン交換輸送系 / H^+ / 性差 / CaCo^2細胞 / 排泄 / cDNA cloning / Xenopus oocyte / transfection / P-glycoprotein / organic cation transporter / organic ahion transporter / tubular secretion / drug transport / メトトレキセート / 動物細胞安定発現系 / アフリカメガユル卵母細胞 / P・糖タンパク質 / アフリカツメガエル卵母細胞 / トランスフェクション / 有機カテオントランスポータ / Nonsteroidal anti-inflammatory drugs / Histidine tesidue / beta-L actam antibiotics / Stable transfectant / β-ランタム抗生物質 / 非ステロイド抗炎症薬 / 安定発現系 / Kinetic analysis / Renal toxicity / Transcellular transport / beta-Lactam antibiotics / Cultured cells / LLC-PK_<1-> / 速度論的解析 / 腎毒性 / β-ラクタム系抗生物質 / ペプチド輸送系 / 培養細胞 / cDNA Cloning / Organic Anions / Renal Tubular Secretion / Peptide Transporter / beta-Lactam Antibiotics / Drug Transport / セファロスポリン / Cephalosporin Antibiotic / アミノ-β-ラクタム抗生物質 / Transporter / Renal Epithelial Cell / Dipeptide Transport System / betaーLactam Antibiotic / Organic Anion / Membrane vesicle / BrushーBorder Membrane / ピリドンカルボン酸系抗菌剤 / βーラクタム抗性物質 / ジペプチド輸送系 / 膜小胞系 / 副作用 / 毒性学 / 肝臓 / 小腸 / メタボリックシンドローム / メトホルミン / 核内受容体 / 転写因子 / 薬剤反応 / ヒト組織 / ELISA測定法 / 薬効評価 / 抗リン酸化ペプチド抗体 / 移植・再生医療 / 細胞膜 / 極性上皮細胞 / 蛋白質間相互作用 / 転写調節 / 臓器移植 / 薬効発現 / 白血球 / 側底膜 / 薬物認識 / LLC-PIC_1 / プロテインキナーゼC / キメラ / バラシクロビル / アシクロビル / PCRクローニング … More
Except Principal Investigator
Pharmacodynamics / シスプラチン / 治療アウトカム / 前立腺癌 / 腎細胞癌 / 膀胱癌 / 泌尿器科癌 / 病態 / 胆汁排泄 / cMOAT / P-450 / トランスポータ / 水チャネル / チャネル / 薬学教育 / 教育研究倫理 / 学術雑誌 / 学術集会 / 研究倫理 / 日本薬学教育学会 / 薬学教育学 / Cisplatin / Cyclosporin / Aminoglycoside / Cultured Renal Epithelial Cell / Cell Culture / Nephrotoxicity / LLC-PK_1細胞 / シクロスポリン / アミノグリコシド系抗生物質 / LLC-PK1細胞 / 培養腎上皮細胞 / 腎毒性 / Renal dysfunction / Hyperthyroidism / Arrhythmias / Disease state models / Design of dosage regimen / Pharmacokinetics / Antiarrhythmics / エフェクトコンパートメントモデル / 心電図 / 心拍数依存性 / 甲状腺機能亢進 / 薬理効果 / 薬物体内動態 / 抗不整脈剤 / プロプラノロ-ル / アジマリン / バイオアベイラビリティ- / 初回通過効果 / 腎疾患 / 甲状腺機能亢進症 / 不整脈 / 病態モデル動物 / 薬物投与計画 / pharmacodynamics / pharmacokinetics / 抗不整脈薬 / Aldosterone / Renal disease / Hepatic disease / Urinary excretion rate of ( <Na^+> + <K^+> ) / Furosemide / Loop diuretics / 濃縮能 / 腎疾患;アルドステロン / 尿中(【Na^+】+【K^+】)排泄速度;肝疾患 / ファルマコダイナミクス / フロセミド / ループ利尿剤 / selective transport / signal transmission / recognition of materials / synthetic membrane / biological membrane / 選択輸送 / 信号伝達 / 物質認識 / 合成膜 / 生体膜 / water channel / signal transduction / tubular cell / mesangium cell / body fluid / hormones / renal function / autoregulation / 利尿 / 高血圧 / 内分泌 / 腎 / 体液調節 / cAMP / 腎尿細管 / カルシウムイオン / オ-トクリン / バゾプレッシン / レセプター / エンドセリン / 情報伝達 / 尿細管 / メサンジウム細胞 / 体液 / ホルモン / 腎機能 / 自動調節機構 / 脳腫瘍 / 徐放性抗癌剤 / ポリ乳酸 / オキシセルロース / アドリアマイシン / 統合的OMICSデータ / 泌尿器科がん / プロテオ-ム / 綱羅的発現解析 / プロテオーム / 網羅的発現解析 / 遺伝子解析 / OMICS / 治療感受性 / インターフェロン / 血清マーカー / 治療効果予測 / 病期診断 / 腫瘍マーカー / 臨床情報 / 賢細胞癌 / 分子マーカー / 治療反応性予測 / テーラーメイド医療 / 薬物作用 / 医療薬学 / 細胞・分子薬学 / 細胞内情報伝達 / 細胞間情報伝達 / 神経・免疫・内分泌相関 / 薬物間相互作用 / CYPアイソザイム / 薬物速度論 / 薬物代謝 / 尿中排泄 / 輸送担体 / cDNAクローニング / oatp / クローニング / アンチポ-タ / シンポータ / 構造と機能 / イオン / 重点領域研究 / 膜輸送 / ポンプ / キャリア / イオンチャネル / 生理学的薬物速度論 / 薬物輸送担体 / 代替法 / 遺伝子診断法 / 遺伝的多型 / 遺伝子発現の調節機構 / 酵素の多様性 / 薬物代謝酵素 / K^+ーATPase / 酸性アミノ酸輸送系 / H^+ーアンチポーター / テトラサイクリン排出タンパク質 / H^+ヘキソース共輸送 / ジペプチド輸送系 / H^+-アンチポーター / イオン輸送 / K^+-ATPase / バクテリオロドプシン / アラニンキャリアー / テトラサイクリン / Band 3 / ジペプチドシンポーター / H^+ / H^+アンチポーター / Na^+ / 共役物質輸送 Less
  • Research Projects

    (44 results)
  • Research Products

    (46 results)
  • Co-Researchers

    (72 People)
  •  The establishment of pedagogy in pharmaceutical education

    • Principal Investigator
      NAKAMURA AKIHIRO
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical sociology
    • Research Institution
      Showa University
  •  薬物間相互作用を利用したシスプラチン腎症の防御とがん化学療法への応用Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyoto University
  •  ヒト薬物トランスポートソームの発現プロファイル構築に基づく薬物動態学的意義の解明Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  PHARMACOKINETICS IN THE PATIENTS WITH METABOLIC SYNDROME AND APPLICATION FOR PHARMACOTHERAPYPrincipal Investigator

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Applied pharmacology
    • Research Institution
      Kyoto University
  •  治療アウトカムに立脚した泌尿器科がんの治療応答性予測のための分子マーカーの開発

    • Principal Investigator
      小川 修
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  ペプチドトランスポートソームの実体解明と発現・局在調節における生理的意義Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Validation of OMICS data of urological malignancies for the clinical use

    • Principal Investigator
      OGAWA Osamu (OSAMU Ogawa)
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Urology
    • Research Institution
      Kyoto University
  •  抗リン酸化ペプチド抗体を用いた高感度カルシニューリン活性測定法の開発と臨床応用Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Applied pharmacology
    • Research Institution
      Kyoto University
  •  治療アストカムに立脚した泌尿器科がんの治療反応性予測のための分子マーカーの開発

    • Principal Investigator
      OGAWA Osamu
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Establishment of personalized immunosuppressive therapy based on molecular mechanisms of transplant immunological networkPrincipal Investigator

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyoto University
  •  薬物トランスポータの発現量変動評価系の構築-薬物体内動態制御薬の開発へ向けてPrincipal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto University
  •  Evaluation of drug interaction and interindividual differences of renal drug excretion based on the genetic polymorphism analysisPrincipal Investigator

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KYOTO UNIVERSTTY
  •  薬物トランスポータの分子認識能に基づく薬物分子設計Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University
  •  免疫抑制剤治療における白血球P-糖蛋白質の役割解明と臨床応用Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kyoto University
  •  薬物トランスポータ分子認識を利用した薬物動態制御システムの構築Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University
  •  Molecular diversity of organic ion transporters and their roles in the renal drug excretionPrincipal Investigator

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY
  •  薬物トランスポータの分子認識能を利用した臓器特異的薬物送達システムの構築Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University
  •  薬剤性腎障害におけるアポトーシス誘動と腎障害発現防御に関する研究Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kyoto University
  •  加齢病態・疾病発病に関わる神経・免疫・内分泌相関の細胞分子・医療薬学的研究

    • Principal Investigator
      野村 靖幸
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  薬剤性腎障害発現におけるアポトーシスの役割に関する研究Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      Kyoto University
  •  異物解毒の分子基盤:代謝・排泄能の分子から個体への予測

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Development of novel systems for evaluation and prediction of drug inteactions based on the reconstruction of drug excretion systems in vitro.Principal Investigator

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KYOTO UNIVERSITY
  •  薬物解毒(代謝・排泄)能力の予測:分子から個体へ

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Molucular analysis of tissue distribution and structure-function relationship of transporters responsible for the regulation of drug transportPrincipal Investigator

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY
  •  イオン駆動型トランスポーターとチャネルの構造・機能協関

    • Principal Investigator
      土屋 友房
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Okayama University
  •  Synthesis and Application of Intelligent interface System

    • Principal Investigator
      FURUSAKI Shintaro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      生物・生体工学
    • Research Institution
      The University of Tokyo
  •  Kietic analysis and evaluation of drug absorption and excretion using cultured cells.Principal Investigator

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      KYOTO UNIVERSITY
  •  薬物動態の分子基盤:解毒(代謝・排泄)能力の予測

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  チャネルとトランスポータの構造・機能協関

    • Principal Investigator
      岡田 泰伸
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      General physiology
    • Research Institution
      Okazaki National Research Institutes
  •  Molecular and Cell Biological Analyzes of Structure and Function of Drug Transporters in the Intestine and Kidney Proximal TubulePrincipal Investigator

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      KYOTO UNIVERSITY
  •  小腸及び腎尿細管上皮細胞における薬物輸送体の分子生物学的研究Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tokyo Medical and Dental University
  •  イオン・溶質輸送と共役ネットワーク

    • Principal Investigator
      川喜田 正夫
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  小腸及び腎尿細管におけるプロトン共役薬物輸送担体の発現と調節Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  小腸及び腎尿細管上皮細胞における薬物輸送担体の構造と機能に関する研究Principal Investigator

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tokyo Medical and Dental University
  •  The Use of Cultured Cells for Alternatives to Animal Experiments in Drag Absorption and SecretionPrincipal Investigator

    • Principal Investigator
      INUI Kenichi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tokyo Medical and Dental University
  •  Study on Autoregulatory Mechanism of Body Fluid with Special Emphasis on Kidney and Hormones

    • Principal Investigator
      MARUMO Fumiaki
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      医学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  Structure and Function of Drug Transporters in the Intestinal and Renal Epithelial CellsPrincipal Investigator

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tokyo Medical and Dental University
  •  In Vitro New Evaluation Method for the Drug Absorption and Secretion Using Membrane VesiclesPrincipal Investigator

    • Principal Investigator
      INUI Kenーichi
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B).
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tokyo Medical and Dental University
      Kyoto University
  •  Regulation Mechanisms of Drug Disposition via H^+-Coupled Active Transport Systems in the Intestinal and Renal Tubular Epithelial CellsPrincipal Investigator

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KYOTO UNIVERSITY
  •  Development of new methods for the evaluation and protection of drug induced nephrotoxicity using kidney epithelial cell line (LLC-PK_1)

    • Principal Investigator
      HORI Ryohei
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KYOTO UNIVERSITY
  •  Pharmacokinetics and Pharmacodynamics of Antiarrhythmic Drugs in Disease State

    • Principal Investigator
      HORI Ryohei
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KYOTO UNIVERSITY
  •  悪性脳腫瘍の手術時における留置用徐放性抗癌剤の開発

    • Principal Investigator
      HORI Ryohei
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University
  •  Localization and Physiological Role of Atrial Natriuretic Polypeptide Receptors in the KidneyPrincipal Investigator

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kyoto University
  •  Pharmacodynamics of loop diuretic, furosemide, in hepatic and renal dysfunction

    • Principal Investigator
      KAMIYA Akira
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kyoto University

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

  • [Book] 改訂3版 腎機能別薬剤使用マニュアル2010

    • Author(s)
      乾賢一
    • Total Pages
      250
    • Publisher
      じほう
    • Data Source
      KAKENHI-PROJECT-20056018
  • [Book] 薬物トランスポータ活用ライブラリー2009

    • Author(s)
      乾賢一
    • Total Pages
      246
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-20056018
  • [Book] 薬物トランスポーター活用ライブラリー2009

    • Author(s)
      乾賢一, 他
    • Total Pages
      246
    • Publisher
      株式会社羊土社
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Book] 薬剤師が変える薬物治療2-安全ながん治療とテーラーメイド医療に向けて-2007

    • Author(s)
      乾 賢一ほか
    • Total Pages
      238
    • Publisher
      じほう
    • Data Source
      KAKENHI-PROJECT-18659157
  • [Journal Article] Effects of metabolic acidosis on expression levels of renal drug transporters.2011

    • Author(s)
      Gaowa A, Motohashi H, Katsura T, Inui K.
    • Journal Title

      Pharm Res 28

      Pages: 1023-1030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Organic cation transporter OCT/SLC22A and H^+/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents.2011

    • Author(s)
      Yonezawa A, Inui K.
    • Journal Title

      Biochem Pharmacol 81

      Pages: 563-568

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.2010

    • Author(s)
      Toyama K, Yonezawa A, Tsuda M, Masuda S, Yano I, Terada T, Osawa R, Katsura T, Hosokawa M, Fujimoto S, Inagaki N, Inui K.
    • Journal Title

      Pharmacogenet Genomics 20

      Pages: 135-138

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain.2010

    • Author(s)
      Yao Y, Yonezawa A, Yoshimatsu H, Masuda S, Katsura T, Inui K.
    • Journal Title

      J Nutr 140

      Pages: 1220-1226

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] ABCG2 421C>A polymorphism and high exposure of sunitinib in a patient with renal cell carcinoma.2010

    • Author(s)
      Mizuno T, Terada T, Kamba T, Fukudo M, Katsura T, Nakamura E, Ogawa O, Inui K.
    • Journal Title

      Ann Oncol 21

      Pages: 1382-1383

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss : a prospective clinical trial.2010

    • Author(s)
      Nakagawa T, Sakamoto T, Hiraumi H, Kikkawa YS, Yamamoto N, Hamaguchi K, Ono K, Yamamoto M, Tabata Y, Teramukai S, Tanaka S, Tada H, Onodera R, Yonezawa A, Inui K, Ito J.
    • Journal Title

      BMC Med 8

      Pages: 76-76

    • NAID

      120002661525

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice.2010

    • Author(s)
      Watanabe S, Tsuda M, Terada T, Katsura T, Inui K.
    • Journal Title

      J Pharmacol Exp Ther 334

      Pages: 651-656

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Immunosuppressive effects of tacrolimus on macrophages ameliorate experimental colitis.2010

    • Author(s)
      Yoshino T, Nakase H, Honzawa Y, Matsumura K, Yamamoto S, Takeda Y, Ueno S, Uza N, Masuda S, Inui K, Chiba T.
    • Journal Title

      Inflamm Bowel Dis 16

      Pages: 2022-2033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats.2010

    • Author(s)
      Nishihara K, Masuda S, Nakagawa S, Yonezawa A, Ichimura T, Bonventre JV, Inui K.
    • Journal Title

      Am J Physiol Renal Physiol 298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Hepatitis C virus-related cirrhosis is a major determinant of the expression levels of hepatic drug transporters.2010

    • Author(s)
      Ogasawara K, Terada T, Katsura T, Hatano E, Ikai I, Yamaoka Y, Inui K.
    • Journal Title

      Drug Metab Pharmacokinet 25

      Pages: 190-199

    • NAID

      10027582589

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Maternal riboflavin deficiency, resulting in transient neonatal-onset glutaric aciduria Type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B.2010

    • Author(s)
      Ho G, Yonezawa A, Masuda S, Inui K, 以下7名
    • Journal Title

      Hum Mutat 32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity.2010

    • Author(s)
      Nakamura T, Yonezawa A, Hashimoto S, Katsura T, Inui K.
    • Journal Title

      Biochem Pharmacol 80

      Pages: 1762-1767

    • NAID

      120002619612

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin.2009

    • Author(s)
      Tsuda M, Terada T, Mizuno T, Katsura T, Shimakura J, Inui K.
    • Journal Title

      Mol Pharmacol 75

      Pages: 1280-1286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2.2009

    • Author(s)
      Kimura N, Masuda S, Katsura T, Inui K.
    • Journal Title

      Biochem Pharmacol 77

      Pages: 1429-1436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Impact of regulatory polymorphisms in organic anion transporter genes in the human liver.2009

    • Author(s)
      Aoki M, Terada T, Ogasawara K, Katsura T, Hatano E, Ikai I, Inui K.
    • Journal Title

      Pharmacogenet Genomics 19

      Pages: 647-656

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.2009

    • Author(s)
      Toyohara T, Suzuki T, Morimoto R, Akiyama Y, Souma T, Shiwaku HO, Takeuchi Y, Mishima E, Abe M, Tanemoto M, Masuda S, Kawano H, Maemura K, Nakayama M, Sato H, Mikkaichi T, Yamaguchi H, Fukui S, Fukumoto Y, Shimokawa H, Inui K, 以下11名
    • Journal Title

      J Am Soc Nephrol 20

      Pages: 2546-2555

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells.2009

    • Author(s)
      Tsuda M, Terada T, Ueba M, Sato T, Masuda S, Katsura T, Inui K.
    • Journal Title

      J Pharmacol Exp Ther 329

      Pages: 185-191

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity.2009

    • Author(s)
      Kajiwara M, Terada T, Ogasawara K, Iwano J, Katsura T, Fukatsu A, Doi T, Inui K.
    • Journal Title

      J Hum Genet 54

      Pages: 40-46

    • NAID

      10030728868

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1.2008

    • Author(s)
      Yonezawa A, Masuda S, Katsura T, Inui K.
    • Journal Title

      Am J Physiol Cell Physiol 295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.2008

    • Author(s)
      Sato T, Masuda S, Yonezawa A, Tanihara Y, Katsura T, Inui K.
    • Journal Title

      Biochem Pharmacol 76

      Pages: 894-903

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Significance of organic cation transporter 3 (SLC22A3) expression for the cytotoxic effect of oxaliplatin in colorectal cancer.2008

    • Author(s)
      Yokoo S, Masuda S, Yonezawa A, Terada T, Katsura T, Inui K.
    • Journal Title

      Drug Metab Dispos 36

      Pages: 2299-2306

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Regulation of basal core promoter activity of human organic cation transporter 1(OCT1/SLC22A1).2008

    • Author(s)
      Kajiwara M, Terada T, Asaka J, Aoki M, Katsura T, Ikai I, Inui K.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Inhibitory effect of zinc on the absorption of beta-lactam antibiotic ceftibuten via the peptide transporters in rats.2008

    • Author(s)
      Okamura M, Terada T, Katsura T, Inui K.
    • Journal Title

      Drug Metab Pharmacokinet 23

      Pages: 464-468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney.2008

    • Author(s)
      Ogasawara K, Terada T, Motohashi H, Asaka J, Aoki M, Katsura T, Kamba T, Ogawa O, Inui K.
    • Journal Title

      J Hum Genet 53

      Pages: 607-614

    • NAID

      10021249665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Regulatory mechanism governing the diurnal rhythm of intestinal H^+/peptide cotransporter 1 (PEPT1).2008

    • Author(s)
      Saito H, Terada T, Shimakura J, Katsura T, Inui K.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation.2008

    • Author(s)
      Aoki M, Terada T, Kajiwara M, Ogasawara K, Ikai I, Ogawa O, Katsura T, Inui K.
    • Journal Title

      Am J Physiol Renal Physiol 295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis.2008

    • Author(s)
      Chen J, Terada T, Ogasawara K, Katsura T, Inui K.
    • Journal Title

      Am J Physiol Renal Physiol 295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] Thyroid hormone regulates the expression and function of P-glycoprotein in Caco-2 cells.2008

    • Author(s)
      Nishio N, Katsura T, Inui K.
    • Journal Title

      Pharm Res 25

      Pages: 1037-1042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Journal Article] An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients2006

    • Author(s)
      Masuda S, Inui K
    • Journal Title

      Pharmacol Ther 112・1

      Pages: 184-198

    • Data Source
      KAKENHI-PROJECT-16209005
  • [Journal Article] Importance of the Multidrug and Toxin Extrusion MATE/SLC47A Family to Pharmacokinetics, Pharmacodynamics /Toxicodynamics and Pharmacogenomics.

    • Author(s)
      Yonezawa A, Inui K.
    • Journal Title

      Br J Pharmacol (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Presentation] 薬物トランスポータ研究の歩み:From Bench to Bedside2010

    • Author(s)
      乾賢一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山市
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-20056018
  • [Presentation] PREDOMINANT ROLE OF H^+/ORGANIC CATION ANTIPORTER MATE1/SLC47A1 IN THE RENAL TUBULAR SECRETION OF METFORMIN AND CEPHALEXIN.2010

    • Author(s)
      Inui K
    • Organizer
      9th International Meeting of International Society for the Study of Xenobiotics
    • Place of Presentation
      イスタンブール(トルコ)
    • Year and Date
      2010-09-05
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Presentation] 腎における薬物動態とトランスポータ2009

    • Author(s)
      乾賢一
    • Organizer
      第3回腎と薬剤研究会学術集会2009
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-09-20
    • Data Source
      KAKENHI-PROJECT-20056018
  • [Presentation] Renal Organic Cation Transporter, OCT & MATE : From Drug Discovery to Clinical Applications2009

    • Author(s)
      Ken-ichi Inui
    • Organizer
      3rd Asian Pacific ISSX Meeting
    • Place of Presentation
      タイ、バンコク
    • Year and Date
      2009-05-10
    • Data Source
      KAKENHI-PROJECT-20056018
  • [Presentation] Thirty year's advances in drug transporters -evolution from de factstandard-2008

    • Author(s)
      Ken-ichi.Inui
    • Organizer
      2008 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
    • Place of Presentation
      Atlanta. U.S.A
    • Year and Date
      2008-11-18
    • Data Source
      KAKENHI-PROJECT-20056018
  • [Presentation] Pharmacogenomics of Immunosuppressants2008

    • Author(s)
      Inui, K.
    • Organizer
      PGRN-Riken-JXXS Joint Workshop of Pharmacogenomics in drug Development
    • Place of Presentation
      東京大学安田記念講堂
    • Year and Date
      2008-02-06
    • Data Source
      KAKENHI-PROJECT-18659157
  • [Presentation] Pharmacogenomics of SLC22A/OCT, OAT and SLC47A/MATE drug transporters2008

    • Author(s)
      Ken-ichi Inui
    • Organizer
      2008 International Conference on Pharmacogenomics
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2008-04-10
    • Data Source
      KAKENHI-PROJECT-20056018
  • [Presentation] 薬剤業務の科学的基盤の確立と薬物治療への展開2008

    • Author(s)
      乾賢一
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2008-05-21
    • Data Source
      KAKENHI-PROJECT-20249036
  • [Presentation] Drug transporters : from bench to bedside2008

    • Author(s)
      Kenichi Inui
    • Organizer
      International Society for the Study of Xenobiotics 2nd AsianPacific Regional Meeting
    • Place of Presentation
      Shanghai, People's Republic of China
    • Year and Date
      2008-05-11
    • Data Source
      KAKENHI-PROJECT-20056018
  • [Presentation] Moleculaz characterisation of H^+/organic cation antiporters (MATEs)2007

    • Author(s)
      Ken-ichi Inui
    • Organizer
      Biomedical Transporters 2007
    • Place of Presentation
      Bem, Switzerland
    • Year and Date
      2007-08-13
    • Data Source
      KAKENHI-PROJECT-18059018
  • [Presentation] Pharmacogenomics of MDR1/ABCB1 and CYP3As in tacrolimus therapy after organ transplantation2007

    • Author(s)
      Ken-ichi Inui
    • Organizer
      Pharmaceutical Sciences World Congress 2007
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      2007-04-25
    • Data Source
      KAKENHI-PROJECT-18059018
  • [Presentation] Pharmacogenomics on tacrolimus therapy in liver transplant patients2007

    • Author(s)
      Ken-ichi Inui.
    • Organizer
      Joint Cold Spring Harbor Laboratory/Wellcome Trust Conference
    • Place of Presentation
      Hinxton, UK
    • Year and Date
      2007-10-19
    • Data Source
      KAKENHI-PROJECT-18059018
  • 1.  SAITO Hideyuki (40225727)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 0 results
  • 2.  KATSURA Toshiya (10283615)
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    # of Collaborated Products: 22 results
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