IKAWA Yoji 井川洋二

Researcher Number	40085618
Affiliation (based on the past Project Information) *help	2003 – 2004: 独立行政法人理化学研究所, 井川特別研究室, 特別招聘研究員 2001 – 2002: 理化学研究所, 井川特別研究室, 特別招聘研究員 2000: 理化学研究所, 招聘研究員 1999: 東京医科歯科大学, 大学院・医学系研究科, 教官 1995 – 1998: Tokyo Medical and Dental University Medical Research Division Professor, 医学系研究科, 教授 … More 1990 – 1997: 東京医科歯科大学, 医学部, 教授 1996: 東京医学歯科大学, 医学部, 教授 1996: Tokyo Medical and Dental University Medical Research Division, Professor, 大学院・医学系研究科, 教授 1994: Tokyo Medical and Dental University School of Medicine, Dept.of Biochemsitry, Professor, 医学部・生化学, 教授 1991 – 1993: 東京医科歯科大学, 医学部生化学, 教授 1992: 東京医科歯科大学, 医学部・生化学, 教授 1989: 理化学研究所, ライフサイエンス筑波研究センター, 副所長 1989: 理科学研究所, 筑波研究センター, 主任研究員 1988: 理化学研究所, 筑波研究センター, 主任研究員 1988: 理研, 筑波研究センター, 主任研究員 1986 – 1988: 理化学研究所, 分子腫瘍, 主任研究員 1987: 理化学研究所, ライフサイエンス筑波研究センター, 主任研究員 1986: 理化学研究所, 分子腫瘍学研究室, 主任研究員 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Human genetics / Cell biology / General medical chemistry Except Principal Investigator Biological Sciences / Hematology
Keywords	Principal Investigator p51 / p63 / p53 / 癌抑制遺伝子 / 皮膚 / 接着因子 / MMP / Tax / Smad / エリスロポエチン受容体 … More / シグナル伝達 / 発生 / インテグリン / 細胞周期 / がん抑制遺伝子 / 分化誘導 / アポトーシス / 温度感受性p53 / 始原生殖細胞の体外培養法 / 点変異p53遺伝子の導入 / 二段階相同組換え法 / p53遺伝子欠損マウス / 新しいES細胞系 / 相同組換え研究技術 / gene family / functional information / sequence information / 椎間板ヘルニア塊の消化 / マトリックス・メタロプロテアーゼ(MMP) / 間葉系細胞分化 / p51遺伝子 / p53関連遺伝子 / 遺伝子機能予測 / Furctional genomics / ファミリー遺伝子 / 近縁遺伝子群 / 機能情報 / 遺伝子情報 / JAK1恒常的リン酸化 / STAT5の核内移行 / STATファミリー / JAKファミリー / Friend病脾 / 貧血症脾 / Friend病 / STAT5の核内移行機構 / EPOR下流のMAPK回路 / JAK・STATファミリー / EPOR / 赤芽球系細胞 / Friend 病 / ウイルス性白血病発症機構 / Signal Transduction / STAT Transcription Factor / JAK Kinase / Erythroleukemia / Erythroid Progenitor Cells / Erythropoietin / サイトカインレセプター / STAT転写因子 / JAKキナーゼ / 赤白血病 / 赤芽球前駆細胞 / エリスロポエチン / Pain-increased Krev-1 expression / Krev-1 expression / novel Ras function / erythropoietin receptor / signal transduction / small G protein / tumour suppressor gene / 増殖抑制遺伝子 / IL-2受容体 / Krev-1の痛み刺激による増強 / Krev-1蛋白の局在 / 新たなRas機能 / 小分子量G蛋白質 / 扁平上皮癌 / 遺伝子発現 / プロテアソーム / リン酸化 / DNA損傷 / FriendウイルスによるJAK1の恒常的リン酸化 / EPOによるSTAT5の核内移行 / STATファミリーのリン酸化 / JAKファミリーのリン酸化 / Friend病脾赤芽球 / EPO受容体(EPOR) / エリスロポエチンシグナル / Friend ウイルス gp55 / Fragment A 結合蛋白 / 赤白血病細胞系 / FragmentA 結合蛋白 / 赤白血病細胞 / Fyn欠失マウス / 変異APC遺伝子導入マウス / Fyn欠損マウス / 変更APC遺伝子導入マウス / WTー1遺伝子 / NFー1遺伝子 / Hox3.5遺伝子 / p53の両側欠損 / がん抑制遺伝子の検証 / ES細胞 / トランスジェニックマウス / 相同組換え法 … More Except Principal Investigator 癌遺伝子 / 造血幹細胞 / エンハンサー / 細胞分化 / 造血因子 / DNA複製 / 造血支持細胞 / 白血病 / アデノウイルス / 転写調節 / 分化 / 痛覚 / 細胞周期 / cdc2 / G1 / G0 / 遺伝子 / myc産物 / HTLV-1 / BKウイルス / 発症機構 / ウイルス / 転写制御 / 造血因子レセプター / シグナル伝達 / 増殖因子受容体 / 増殖因子 / 転写因子 / 骨髄移植 / 造血調節因子 / c-myc / 遺伝子欠損マウス / サイトカイン / インターロイキン / c-kit / G蛋白質 / キメラcDNA / ガン遺伝子 / リン酸化 / タキキニン / フレンド白血病 / チロシンリン酸化 / cーmyb / cーmyc / プログラミング / ミエロペルオキシダーゼ / Interferon / Human retroviral infection / IRF / ATL / ヒトレトロウイルス / インターフェロン調節因子 / インターフェロン / ヒトレトロウイルス感染 / meiotic synapsis and recombination / nuclear lamina / nuclear-cytoplasmic transport / chromosome / cell nucleus / chromatin remodeling / centromere / tetlmere / 染色体構造 / 細胞核機能 / 細胞核構造 / two hybrid システム / in situ ハイブリダイゼーション / 分子複合体 / 分子細胞生物学 / タンパク質核移行 / ヘテロクロマチン / スピンドル極体 / テロメレース / Ran / importinβ / 原子間力顕微鏡 / LCR配列 / 核タンパク質輸送 / 細胞核機能構造 / 相同染色体合と組換え / 核ラミア / セントロメア / テロメア / クロマチンリモデリング / 核・細胞質間タンパク質輸送 / 染色体 / 細胞内情報ネットワーク / 染色体機能装置 / 核内機能構造 / 核-細胞質間分子輸送 / クロマチン / 核内分子複合体 / 細胞核 / signal transduction / Kno-ck-out mouse / Transcription factor / Impact factor / Hemoietic factor / Death signal / Differentiation signal / Hemopoietic stem / 造血幹細胞移植 / 造血微小環境 / チロシンキナーゼ / 造血幹細胞の精製 / 増殖の制御 / ノックアウト・マウス / 受容体チロシンキナーゼ / 分化制御 / Jak-Stat系 / シグナル伝進 / 遺伝子改変動物 / インパクトファクター / 死のシグナル / 分化シグナル / G protein / Ubiquitin / Cycline / Map Kinase / Mitosis / DNA replication / プロテアソーム / ライセンス因子 / M / G2 / 染色体分配 / コビキチン / Gタンパク / ユビキチン / サイクリン / MAPキナーゼ / M期 / genetic diseases / human genome / recombinant DNA / training course / biotechnology / guideline / DNA experiment / bioscience / バイオトレ-ニングコ-ス / cDNA / 安全審査 / ヒト・ゲノム / バイオトレーニングコース / 安全指針 / 遺伝子治療 / 遺伝子病 / ヒトゲノム / バイオテクノロジー / ガイドライン / 遺伝子研究施設 / 組換えDNA実験技術 / バイオサイエンス / HPV / BKV / myc遺伝子 / WW^vマウス / PCR / トランスジェニックマウス / 白血病株細胞 / 造血因子遺伝子 / 造血細胞 / 感受性 / HTLVー1 / 糖蛋白 / リンホーマ / 白血病ウイルス / 再構成ウイルス / AP-1 / Smad / プロスタグランジンJ_2 / TGF-β1 / p53 / p51(p63) / 細胞分化決定 / レセプター・チロシンキナーゼ / ミュータントマクス / 造血因子受容体 / アポトーシス / 細胞増殖 / アプトーシス / 増殖 / 自己再生 / 造血調節因子レセプター / レセプターチロシンキナーゼ / ES細胞 / c-maf / c-myb / ニワトリ / ゼブラフィッシュ / ヒト疾患モデル / マウスゲノム / 標的組換え / 標的遺伝子組換え / 脊髄切片 / ペプチダーゼ阻害剤 / オピオイド受容体 / ガラニン / 低分子量G蛋白質 / 非ペプチド性タキキニン拮抗薬 / 鎮痛 / 分子生物学 / 発現クローニング / 情報伝達 / レセプター / コロニー刺激因子 / Myb / c-Myc / 興奮性アミノ酸 / 情報伝達機構 / 転写 / 痛みの伝連達機構 / 内因性活性物質 / 無髄C線維 / 細胞内情報伝達 / cーkit / 白血病細胞の分化 / 造血因子レセプタ- / ras / 重点領域研究 / 白血病細胞 / 貧血マウス / 松果体 / がん遺伝子 / フレンドウイルス / クローン性増殖 Less

p51/p63による細胞接着因子の発現誘導と組織発生および腫瘍化の関連Principal Investigator
- Principal Investigator
  
  井川洋二
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
p53ファミリーp51/p63遺伝子が上皮細胞恒常性維持に果たす役割Principal Investigator
- Principal Investigator
  
  井川洋二
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
p53とそのホモログp51/p63が示すがん細胞抑制作用の違いについてPrincipal Investigator
- Principal Investigator
  
  井川洋二
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
p53ファミリーp51/p63遺伝子産物の活性化と細胞応答Principal Investigator
- Principal Investigator
  
  井川洋二
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
p53類似遺伝子p51の活性化機構の解析と脱腫瘍化への応用
- Principal Investigator
  
  山村康子
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Identification of Gene Function from Sequence InformationPrincipal Investigator
- Principal Investigator
  
  YAMAMURA Yasuko, 井川洋二
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  Tokyo Medical and Dental University
サイトカインシグナル伝達経路の修飾による白血病誘導の特徴Principal Investigator
- Principal Investigator
  
  井川洋二
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
温度感受性変異p53遺伝子を持つマウス赤白血病細胞の生物特性Principal Investigator
- Principal Investigator
  
  井川洋二
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
Deregulation of IRF Menbers in Human Retroviral Infection
- Principal Investigator
  
  MATSUYAMA Toshifumi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Nagasaki University
造血系シグナル伝達における細胞質チロシンキナーゼ及び核移行転写制御因子の特異性Principal Investigator
- Principal Investigator
  
  井川洋二
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Medical and Dental University
温度変異p53遺伝子を持つマウス赤白血病細胞の生物特性Principal Investigator
- Principal Investigator
  
  井川洋二
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
Functional structure of cell nucleus : Molecular consttitution and intermolecualr communicaticns
- Principal Investigator
  
  MIZUNO Shigeki
- Project Period (FY)
  1995 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
造血幹細胞の定着・増殖・分化・死のシグナル
- Principal Investigator
  
  北村幸彦
- Project Period (FY)
  1994 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
細胞分化の決定と癌遺伝子の役割
- Principal Investigator
  
  帯刀益夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Signaling Mechanism Downstream of Erythropoietin ReceptorPrincipal Investigator
- Principal Investigator
  
  IKAWA Yoji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University
Regulation of Hemopoietic Stem Cells and Its Clinical Application
- Principal Investigator
  
  KITAMURA Yukihiko
- Project Period (FY)
  1994 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
細胞分化の決定と癌遺伝子の役割
- Principal Investigator
  
  帯刀益夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
相同組換え遺伝子導入による発癌機構の研究Principal Investigator
- Principal Investigator
  
  井川洋二
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo Medical and Dental University
造血幹細胞制御と臨床応用に向けての基礎研究
- Principal Investigator
  
  北村幸彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
cell cycle regulation
- Principal Investigator
  
  NISHIMOTO Takeharu
- Project Period (FY)
  1993 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  KYUSHU UNIVERSITY
細胞分化の決定と癌移伝子の役割
- Principal Investigator
  
  帯刀益夫
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
造血因子の構造と作用の分子生物学的検討と生体内作用
- Principal Investigator
  
  ATRAI Kenichi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
痛覚を伝える一次求心性線維の伝達物質と情報伝達機構
- Principal Investigator
  
  大塚正徳
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
標的遺伝子組換えによる生体機能の研究
- Principal Investigator
  
  勝木元也
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Kyushu University
Investigation of physiological function of the cell growth-regulating G-proteins and their signaling pathways.Principal Investigator
- Principal Investigator
  
  IKAWA Yoji
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
細胞分化のプログラミングと癌遺伝子
- Principal Investigator
  
  帯刀益夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
相同組換え遺伝子導入による発癌機構の研究Principal Investigator
- Principal Investigator
  
  井川洋二
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo Medical and Dental University
痛覚を伝える一次求心性線維の伝達物質と情報伝達機構
- Principal Investigator
  
  大塚正徳
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
相同組換え遺伝子導入による発癌機構の研究Principal Investigator
- Principal Investigator
  
  井川洋二
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo Medical and Dental University
造血幹細胞の分化増殖の生物学的解析
- Principal Investigator
  
  三浦恭定
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
痛みの伝達機構と内因性活性物質
- Principal Investigator
  
  大塚正徳
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Tokyo Medical and Dental University
The Study of Present Circumstances with Respect to Research and Education of Bioscience in Japan
- Principal Investigator
  
  WABANABE Itaru
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Institution
  Keio University
造血幹細胞の不死化・白血病化によるクローン性増殖発展の制御機構
- Principal Investigator
  
  MIUA Yasusada
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jichi Medical University
造血幹細胞の分化増殖の分子生物学的解析
- Principal Investigator
  
  三浦恭定
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Jichi Medical University
細胞分化のプログラミングと癌遺伝子
- Principal Investigator
  
  帯刀益夫
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
ウイルス性白血病の発症機構の解析
- Principal Investigator
  
  小高健
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
造血幹細胞の不死化・白血病化によるクローン性増殖発展の制御機構
- Principal Investigator
  
  三浦恭定
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jichi Medical University
癌遺伝子の転写と複製の調節
- Principal Investigator
  
  吉池邦人
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  国立予防衛生研究所
ウイルス性白血病の発症機構の解析
- Principal Investigator
  
  小高健
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
癌遺伝子の転写の複製の調節
- Principal Investigator
  
  吉池邦人
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  国立予防衛生研究所
ウイルス性白血病の発症機構の解析
- Principal Investigator
  
  小高健
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
癌遺伝子の転写と複製の調節
- Principal Investigator
  
  吉池邦人
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  国立予防衛生研究所

All 2004

All Journal Article

[Journal Article] Dimerization and processing of procaspase-9 by redox stress in mitochondria2004
- Author(s)
  Katoh, I., Tomimori, Y., Ikawa, Y., Kurata, S.
- Journal Title
  
  Journal of Biological Chemistry 279(15)
  
  Pages: 15515-15523
- Data Source
  KAKENHI-PROJECT-16021260

1. KITAMURA Yukihiko (70028520)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. YAMAMURA Yasuko (50146809)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. MIUA Yasusada (60048965)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. 帯刀益夫 (10099971)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. 高久史磨 (40048955)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. 石井俊輔 (00124785)

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101. TAK W. Mak

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IKAWA Yoji 井川 洋二

Research Projects

Research Products

Co-Researchers

p51/p63による細胞接着因子の発現誘導と組織発生および腫瘍化の関連Principal Investigator

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Project Period (FY)

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p53ファミリーp51/p63遺伝子が上皮細胞恒常性維持に果たす役割Principal Investigator

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p53とそのホモログp51/p63が示すがん細胞抑制作用の違いについてPrincipal Investigator

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p53ファミリーp51/p63遺伝子産物の活性化と細胞応答Principal Investigator

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Principal Investigator

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Identification of Gene Function from Sequence InformationPrincipal Investigator

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サイトカインシグナル伝達経路の修飾による白血病誘導の特徴Principal Investigator

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Project Period (FY)

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温度感受性変異p53遺伝子を持つマウス赤白血病細胞の生物特性Principal Investigator

Principal Investigator

Project Period (FY)

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Principal Investigator

Project Period (FY)

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造血系シグナル伝達における細胞質チロシンキナーゼ及び核移行転写制御因子の特異性Principal Investigator

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Project Period (FY)

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Research Institution

温度変異p53遺伝子を持つマウス赤白血病細胞の生物特性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Principal Investigator

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Principal Investigator

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Research Institution

Signaling Mechanism Downstream of Erythropoietin ReceptorPrincipal Investigator

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IKAWA Yoji 井川洋二