SEMBA Kentaro 仙波憲太郎

… Alternative Names

仙波憲太郎センバケンタロウ

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Researcher Number	70206663
Other IDs	https://orcid.org/0000-0001-7507-8214
Affiliation (Current)	2025: 早稲田大学, 理工学術院, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 早稲田大学, 理工学術院, 教授 2011 – 2017: 早稲田大学, 理工学術院, 教授 2007: Waseda University, Dept. of Life Science and Medical Bioscience, professor 2006: 東京大学, 医科学研究所, 助教授 1999 – 2004: 東京大学, 医科学研究所, 助教授 … More 1995 – 1996: 東京大学, 医科学研究所, 助教授 1991: 東京大学医科学研究所, 制癌研究部, 助手 1989 – 1991: 東京大学, 医科学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Human pathology / General anatomy (including histology/embryology) / Basic Section 50010:Tumor biology-related / Medium-sized Section 50:Oncology and related fields / Obstetrics and gynecology / Medical genome science Except Principal Investigator Biological Sciences / Immunology
Keywords	Principal Investigator SRY / WT1 / がん / ErbB2 / sex / 性 / 脱分化 / 乳腺 / 組織形成 / 細胞分化 … More / 幹細胞 / ゲノム / 遺伝子増幅 / c-Jun / 骨転移 / 乳がん / ケミカルスクリーニング / ケミカルバイオロジー / 発がん / 細胞間作用 / 質量分析 / 細胞運動 / 化合物スクリーニング / 細胞間相互作用 / 乳腺組織 / トラップ法 / 遺伝子スクリーニング / リプログラミング / 癌幹細胞 / ダイレクトリプログラミング / signal transduction / proteome / gene amplification / Cancer / シグナル伝達 / プロテオーム / 癌 / DNA chip / microarray / DNAチップ / マイクロアレイ / 精巣 / 性逆転 / 生殖腺 / 性決定 / 乳腺幹細胞 / 再生医療 / 婦人科腫瘍学 / ゲノム発現 / 分子腫瘍学 / 疾患関連遺伝子 / カエル / 腎臓 / 発生 … More Except Principal Investigator シグナル伝達 / 癌 / チロシンキナ-ゼ / 転写制御 / Tリンパ球 / fyn / 細胞周期 / WT1 / 細胞増殖 / 転写因子 / 遺伝子発現 / がん遺伝子 / 遺伝子導入 / lpr / チロシン燐酸化酵素 / Gene Therapy / Drug Design / Cell Adhesion / Cell Cycle / Signal Transduction / Information Exchange / Cancer / International Scientific Research / 癌化学療法 / 癌遺伝子治療 / ドラッグデザイン / 情報交換 / 化学発癌 / 癌治療 / 細胞接着 / ウイルス発癌 / 遺伝子治療 / 薬品設計 / 細胞社会学 / 海外派遣 / 国際学術 / BAL1 / フィラミン / PEBP2β / 細胞骨格 / マイクロアレイ / RunX / キメラ遺伝子 / 白血病 / AML1 / PEBP2 / Gタンパク質 / TRAFタンパク質 / 無汗性外胚葉形成不全症 / IKK / AP-1 / NFkB / 免疫学 / 発生・分化 / 器官形成 / 発生 / 免疫 / 骨形成 / 発現制御 / DRG / Tax / HTLV-1 / TRAF6 / NFκB / 再構成実験系 / 遺伝子操作 / チロシナ燐酸化 / 細胞内情報伝達 / 活性化 / 抗原レセプタ- / PLCγ / GAP / チロシン燐酸化 / lprマウス / MRL / T細胞ハイブリドーマ / Fyn / 抗原レセプター / トランスジェニックマウス / 転写調節 / 増殖因子 / 乳癌 / リンパ球活性化 / 癌抑制遺伝子 / 蛋白質リン酸化酵素 / リン酸化 / 癌遺伝子 / cーerbBー2 / cーyesプロモ-タ- / T細胞活性化反応 / 抗原受容体 / がん原遺伝子 / T細胞抗原レセプタ- / Srcファミリ- / 情報伝達 / 受容体 / 増殖・分化因子 / サイトカイン / ear-3 / ear-1 / erbB-2 / fgr / lyn / yes / srcファミリー Less

Functional analysis of photo-oncogene c-Jun in bone metastasis of breast cancerPrincipal Investigator
- Principal Investigator
  
  仙波憲太郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Waseda University
正常―がん細胞間作用に基づくがん防御機構の化学生物学的解析Principal Investigator
- Principal Investigator
  
  仙波憲太郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Waseda University
Screening for genes involved in efficient reprogramming directly into mammary stem cellsPrincipal Investigator
- Principal Investigator
  
  Semba Kentaro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Waseda University
Generation of mammary stem cells by direct reprogrammingPrincipal Investigator
- Principal Investigator
  
  SEMBA Kentaro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Waseda University
Development of experimental techniques for the analysis of amplicomicsPrincipal Investigator
- Principal Investigator
  
  SEMBA Kentaro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical genome science
- Research Institution
  Waseda University
Identification and functional analysis of novel oncogenes involved in the breast cancer genesis and promotionPrincipal Investigator
- Principal Investigator
  
  SEMBA Kentaro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Waseda University
  The University of Tokyo
白血病細胞における細胞骨格・転写・細胞周期の制御異常
- Principal Investigator
  
  佐竹正延
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Molecular mechanism of sex determination and its diseasePrincipal Investigator
- Principal Investigator
  
  SEMBA Kentaro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  The University of Tokyo
転写制御の異常と細胞の増殖・分化
- Principal Investigator
  
  INOUE Jun-ichiro
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Keio University
Molecular mechanism of sex determination and its diseasePrincipal Investigator
- Principal Investigator
  
  SEMBA Kentaro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  The University of Tokyo
小児腎腫瘍の発症メカニズムの解析Principal Investigator
- Principal Investigator
  
  仙波憲太郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Information Exchange on Cancer Research with North American
- Principal Investigator
  
  YAMAMOTO Tadashi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  The University of Tokyo
細胞癌化における蛋白質リン酸化
- Principal Investigator
  
  秋山徹
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
Tリンパ球抗原レセプターに会合するチロシン燐酸化酵素Fynの機能
- Principal Investigator
  
  片桐拓也
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
がんの増殖と分化に関連する遺伝子の発現制御
- Principal Investigator
  
  長田重一
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka Bioscience Institute
Srcファミリ-遺伝子fynのリンホ-マ並びに正常リンパ球における発現と機能
- Principal Investigator
  
  片桐拓也
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
がん遺伝子の機能解析
- Principal Investigator
  
  山本雅
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
がん遺伝子の機能解析
- Principal Investigator
  
  山本雅
- Project Period (FY)
  1990 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
srcファミリー遺伝子fynのリンホーマ並びに正常リンパ球における発現と機能
- Principal Investigator
  
  片桐拓也
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
がん遺伝子の検出と機能解析
- Principal Investigator
  
  豊島久真男
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo

All 2024 2022 2013 2012 2011 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells2022
- Author(s)
  Aoyama Megumi、Ishikawa Kosuke、Nemoto Shuntaro、Hirano Hiroyuki、Watanabe Nobumoto、Osada Hiroyuki、Watanabe Shinya、Semba Kentaro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 12 Pages: 102635-102635
- DOI
  10.1016/j.jbc.2022.102635
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19418, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21J14495, KAKENHI-PUBLICLY-21H00295
[Journal Article] Effect of lonidamine derivatives on the inhibition of transformed cell area expansion2022
- Author(s)
  Aoyama Megumi、Homma Taiki、Koharazawa Ryohto、Suhara Yoshitomo、Semba Kentaro
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 34 Pages: 101480-101480
- DOI
  10.1016/j.bbrep.2023.101480
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21J14495, KAKENHI-PROJECT-21K19418
[Journal Article] Gene amplification: mechanisms and involvement in cancer2013
- Author(s)
  Semba, K et al.
- Journal Title
  
  Biomolecular Concepts
  
  Volume: 4 Issue: 6 Pages: 567-582
- DOI
  10.1515/bmc-2013-0026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23241064
[Journal Article] Gene amplification : mechanisms and involvement in cancer2013
- Author(s)
  Matsui, A., Ihara, T., Suda, H., Mikami, H., and Semba, K
- Journal Title
  
  Biomolecular Concepts
  
  Volume: 4 Pages: 567-582
- Data Source
  KAKENHI-PROJECT-23241064
[Journal Article] Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene2012
- Author(s)
  Saito, M., Kato, Y., Ito, E., Fujimoto, J., Ishikawa, K., Doi, A., Kumazawa, K., Matsui, A., Takebe, S., Ishida, T., Azuma, S., Mochizuki, H., Kawamura, Y., Yanagisawa, Y., Honma, R., Imai, J., Ohbayashi, H., Goshima, N., Semba, K., and Watanabe, S
- Journal Title
  
  FEBS letters
  
  Volume: 586 Pages: 1708-1714
- Data Source
  KAKENHI-PROJECT-23241064
[Journal Article] ErbB2/HER2 : Its Contribution to Basic Cancer Biology and the Development of Molecular Targeted Therapy, Breast Cancer - Carcinogenesis2011
- Author(s)
  Yamamoto, T., Saito, M., Kumazawa, K., Doi, A., Matsui, A., Takebe, S., Amari, T., Oyama, M., and Semba, K
- Journal Title
  
  Cell Growth and Signalling Pathways, Prof. Mehmet Gunduz (Ed.) (InTech)
- DOI
  10.5772/21965
- ISBN
  9789533077147
- Data Source
  KAKENHI-PROJECT-23241064
[Journal Article] FoxA1 as a lineage-specific oncogene in luminal type breast cancer.2008
- Author(s)
  Yamaguchi, N., Ito, E., Azuma, S., Honma, R., Yanagisawa, Y., Nishikawa, A., Kawamura, M., Imai, J., Tatsuta, K., Inoue, J., Semba, K., Watanabe, S.
- Journal Title
  
  Biochem Biophys Res Commun 365
  
  Pages: 711-717
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591825
[Journal Article] NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells.2008
- Author(s)
  Yamaguchi, N., Oyama, T., Ito, E., Satoh, H., Azuma, S., Hayashi, M., Shimizu, K., Honma, R., Yanagisawa, Y., Nishikawa, A., Kawamura, M., Imai, J., Ohwada, S., Tatsuta, K., Inoue, J., Semba, K., Watanabe, S.
- Journal Title
  
  Cancer Res 68
  
  Pages: 1881-1888
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591825
[Journal Article] AYUMS : an algorithm for completely automatic quantitation based on LC-MS/MS proteome data and its application to the analysis of signal transduction.2007
- Author(s)
  Saito A, Nagasaki M, Oyama M, Kozuka-Hata H, Semba K, Sugano S, Yamamoto T, Miyano S
- Journal Title
  
  BMC Bioinformatics 8
  
  Pages: 15-15
- Data Source
  KAKENHI-PROJECT-18591825
[Journal Article] Novel clusters of highly expressed genes accompany genomic amplification in breast cancers.2007
- Author(s)
  Ito, E., Honma, R., Yanagisawa, Y., Imai, J., Azuma, S., Oyama, T., Ohwada, S., Akiyama, T., Nomura, N., Inoue, J., Watanabe, S., Semba, K.
- Journal Title
  
  FEBS Lett 581
  
  Pages: 3909-3914
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591825
[Journal Article] Diversity of translation start sites may define increased complexity of the human short ORFeome.
- Author(s)
  Oyama M, Kozuka-Hata H, Suzuki Y, Semba K, Yamamoto T, Sugano S.
- Journal Title
  
  Mol. Cell. Proteomics (in press)
- Data Source
  KAKENHI-PROJECT-18591825
[Presentation] 抗がん化合物 Lonidamine の標的因子の探索2024
- Author(s)
  渡邉史織、土井雄太、仙波憲太郎
- Organizer
  第28回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19418
[Presentation] 正常－がん細胞間相互作用を制御する化合物のスクリーニングとその機能解析2022
- Author(s)
  青山愛、平野弘之、渡邉信元、長田裕之、仙波憲太郎
- Organizer
  第74回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-21K19418
[Presentation] ドーパミン拮抗薬ドンペリドンは受容体非依存的にがん細胞の拡大を抑制する2022
- Author(s)
  青山愛、平野弘之、渡邉信元、長田裕之、仙波憲太郎
- Organizer
  第26日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19418
[Presentation] 正常－がん細胞間相互作用を制御する化合物のスクリーニングとその機能解析2022
- Author(s)
  青山愛、平野弘之、渡邉信元、長田裕之、仙波憲太郎
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19418
[Presentation] Identification of novel gene amplification units in breast cancer2006
- Author(s)
  Semba K
- Organizer
  65^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2006-09-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591825
[Presentation] 乳癌における新規遺伝子増幅部位の同定2006
- Author(s)
  仙波憲太郎
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2006-09-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591825

1. YAMAMOTO Tadashi (40134621)

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2. 片桐拓也 (70126100)

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3. 豊島久真男 (90029760)

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55. 川畑正博 (60224838)

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56. 垣塚彰 (80204329)

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57. 石崎寛治 (70111987)

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58. 矢守隆夫 (60200854)

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59. 吉田純 (40158449)

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60. 浜田洋文 (00189614)

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61. 成宮周 (70144350)

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62. 中村祐輔 (70217909)

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63. 月田承一郎 (50155347)

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64. 谷口維紹 (50133616)

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65. 竹縄忠臣 (40101315)

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66. 曽根三郎 (40145024)

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67. 伊藤嘉明 (80004612)

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68. 浅野茂隆 (50134614)

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69. 渡邉信元 (90221689)

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70. 中山淳 (30801237)

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71. 松田覚

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72. 渡辺信元

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# of Collaborated Products: 5 results

SEMBA Kentaro 仙波 憲太郎

仙波 憲太郎 センバ ケンタロウ

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Functional analysis of photo-oncogene c-Jun in bone metastasis of breast cancerPrincipal Investigator

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正常―がん細胞間作用に基づくがん防御機構の化学生物学的解析Principal Investigator

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Screening for genes involved in efficient reprogramming directly into mammary stem cellsPrincipal Investigator

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Generation of mammary stem cells by direct reprogrammingPrincipal Investigator

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Development of experimental techniques for the analysis of amplicomicsPrincipal Investigator

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Identification and functional analysis of novel oncogenes involved in the breast cancer genesis and promotionPrincipal Investigator

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Molecular mechanism of sex determination and its diseasePrincipal Investigator

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Molecular mechanism of sex determination and its diseasePrincipal Investigator

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小児腎腫瘍の発症メカニズムの解析Principal Investigator

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SEMBA Kentaro 仙波憲太郎

仙波憲太郎センバケンタロウ