Kubo Yoshihiro 久保義弘

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KUBO Yoshihiro 久保義弘

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Researcher Number	80211887
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Affiliation (Current)	2025: 生理学研究所, 分子細胞生理研究領域, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 生理学研究所, 分子細胞生理研究領域, 教授 2015: 生理学研究所, 神経機能素子研究部門, 教授 2004 – 2015: 生理学研究所, 分子生理研究系, 教授 2003: Tokyo Medical and Dental University Graduate School, Department of Physiology, Professor, 大学院・歯学総合研究科, 教授 2000 – 2003: Tokyo Medical and Dental University Graduate School Department of Physiology, Professor, 大学院・医歯学総合研究科, 教授 … More 1999: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員 1998: (財)東京都神経科学総合研究所, 神経生理, 副参事研究員 1997 – 1998: (財)東京都神経科学総合研究所, 神経生理学研究部門, 副参事研究員 1996: (財)東京都神経科学総合研究所, 神経細胞生物学研究部門, 主任研究員 1994 – 1996: (財)東京都神経科学総合研究所, 神経生理, 主任研究員 1995: 東京都神経科学総合研究所, 神経生理, 主任研究員 1994 – 1995: 東京都神経科学総合研究所, 主任研究員 1993: 東京都神経科学総合研究所, 神経生理学研究部門, 主任研究員 1989: Tokyo Metropolitan Institute for Neurosciences, Research Scientist, 神経生理, 研究員 Less
Review Section/Research Field	Principal Investigator Biological Sciences / General physiology / General physiology / 神経・脳内生理学 / Basic Section 48020:Physiology-related Except Principal Investigator General physiology / Neurophysiology and muscle physiology / Biophysics / Neurochemistry/Neuropharmacology / Biological Sciences
Keywords	Principal Investigator 生体分子 / 生理学 / 蛋白質 / 神経科学 / 受容体 / シグナル伝達 / 動的構造変化 / ATP受容体 / FRET / グルタミン酸 … More / 構造変化 / 代謝型 / cDNA / イオンチャネル / P2X2 / 細胞内局在 / dynamin / GTP結合蛋白質 / 構造機能連関 / 内向き整流性 / 蛍光非天然アミノ酸 / ATP受容体チャネル / glutamate / metabotropic / 発現密度 / ミトコンドリア / cAMP / カルシウム / IRK1 / 点変異 / 内向き整流性K^+チャネル / P2X / イオン透過 / GFP / receptor / calcium / 代謝型受容体 / 単粒子構造解析 / 遺伝子改変マウス / Gd3+ / 代謝型グルタミン酸受容体 / チャネルポア / CDNA / Gd^<3+> / Homer / グルタミン酸受容体 / 細胞外Ca^<2+> / ポア / アフリカツメガエル卵母細胞 / カップリング / 非典型的膜電位依存性ゲーティング / 遷移金属イオン / 遷移金属 / tmFRET / 膜電位固定下蛍光測光 / 光学解析 / 非天然蛍光アミノ酸 / Signal transduction / Protein / Biomolecule / Neuroscience / Physiology / functional ragulation / structure-function relationship / structural rearrangement / phospholipids / single particle structure analysis / ATP receptor / Sf9細胞 / バキュウロウイルス / ゲート機構 / 膜電位依存性 / 機能調節 / リン脂質 / fragmentation / mutant / optic nerve atrophy / mitochondria / neuron / large GTP binding protein / 断裂化 / 変異体 / 視神経萎縮 / 神経細胞 / 高分子量GTP結合蛋白質 / Cys変異 / IRK1チャネル / sensing / recceptor / Ca^<2+>イメージング / 網羅的行動解析 / オーファン代謝型受容体 / 長期保持 / 恐怖条件付け記憶 / スプライス異型 / オーファン受容体 / Prrt3 / ATP / タンパク質 / スプライス変異 / オーファン / FRET解析 / P2X2チャネル / バキュロウイルス / 細胞長変化 / 細胞収縮 / ゲート電流 / 外有毛細胞 / プレスチン / target vector / ES細胞 / ノックインマウス / スライスパッチクランプ / 情報伝達 / 代謝型グルミン酸受容体 / 2量体 / FRET法 / ゲート / イオン選択性 / 光学的測定 / CHO細胞 / pore / mutagencsis / scanning / cystcinc / channel / potassinm / rectifier / inrvard / キメラ / 細胞外ポタシウム / cysteine / ポタシウムチャネル / G-protein / chimera / CIR / IRK2 / mntation / extrecellular K^+ / GZRK1 / 脳 / 発生 / 軸索 / 抗体 / ポタシウムチャネル / ポロアミン / 内細胞Mg^<2+> / 膜電位固定 / ポタシウムチャンネル / 細胞外K^+ / ミューテーション / ZRK1 / 発現調節 / cDNAクローニング / 筋分化決定遺伝子 / 分化初期過程 / 筋芽細胞 / 中胚葉系幹細胞 … More Except Principal Investigator イオンチャネル / FRET / ウイルスベクター / 脳分子プロファイル / モデル動物 / 脳画像データベース / ブレインバンク / 技術開発支援 / 研究リソース支援 / 若手研究者育成支援 / 技術開発 / 研究リソース / 研究集会 / 研究支援 / 脳科学 / Retinoic Acid / Teratocarcinoma / Anomalous K Rectifier / Proteolysis / Na Channels / Isolated Blastomere / Protochordate Embryo / Neural Induction / Caチヤネル / Naチヤネル / 押神経型分化 / マウス奇形腫細胞 / 誘導分化 / 神経型分化 / ホヤ胚単離割球 / 筋細胞分化 / 中胚葉系幹細胞 / レチノ-ル酸 / 奇形腫細胞 / 異常整流性Kチャネル / プロテオリシス / Naチャネル / 単離割球 / 原索動物胚 / 誘導性神経分化 / Cryo-electron microscopy / Molecular biology / Patch clamp / Model channel / Dynamical structure / Higher order structure / Ion channels / 合成チャネル / 電気生理学 / チャネル蛋白質 / クローニング / 動的構造機能連関 / 分子動力学 / クライオ電顕 / 分子生物学 / パッチクランプ / モデルチャネル / 動的構造 / 高次構造 / 振動分光法 / 分子科学 / 生物物理学 / 赤外分光法 / receptor / kinetics / imaging / G protein / GPCR / Gタンパク質 / Gタンパク質共役型受容体 / カリウムチャネル / Kir2 / 内向き整流カリウム電流 / チャネル開閉機構 / 内向き整流Kチャネル / マルチシグナリング / G蛋白質共役型受容体 / G蛋白質 / 代謝型グルタミン酸受容体 / 分子・細胞生理学 / 細胞膜移行 / 脱感作 / 情報伝達 / Gタンパク / 受容体 Less

チャネルにおけるイオン透過と非典型的膜電位依存性ゲーティングのカップリングの検証Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  National Institute for Physiological Sciences
tmFRET analysis of the dynamic structural rearrangements of ion channelsPrincipal Investigator
- Principal Investigator
  
  Kubo Yosihiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  National Institute for Physiological Sciences
Analysis of dynamic structural rearrangements of functioning ion channels by fluorescent unnatural amino acidPrincipal Investigator
- Principal Investigator
  
  KUBO YOSHIHIRO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
Analyses of structural rearrangements of membrane proteins by fluorescent unnatural amino acid scanningPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshihiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
Analyses of an orphan metabotropic receptor which plays a role in the long term retention of memory, and a secretory protein encoded by its splice variantPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
Functional expression of mammalian ion channels and analysis of the molecular mechanisms
- Principal Investigator
  
  FURUTANI Yuji
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Institute for Molecular Science
Analyses of the function of Prrt3, an orphan family C metabotropic recptorPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
High time resolution FRET analysis of the activation of G protein
- Principal Investigator
  
  TATEYAMA Michihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
Analyses of the signal flow upon activation of ATP receptor channel by tandem repeat constructsPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshihiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
Molecular mechanisms of the physiologically relevant component of the inward rectifier potassium channels that shows low sensitivity to the channel blockers
- Principal Investigator
  
  YANAGI Keiko (ISHIHARA Keiko)
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Saga University
Comprehensive Brain Science Network
- Principal Investigator
  
  Kimura Minoru
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Center for Novel Science Initatives, National Institutes of Natural Sciences
TRPA1チャネルのカフェインに対する応答の質的種間差異に基づく活性化機構の解明Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
膜電位-細胞長変換素子プレスチンの分子構築と動的構造変化の解析Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
Analyses of an orphan metabotropic receptor and a secretion protein encoded by the same genePrincipal Investigator
- Principal Investigator
  
  KUBO Yoshihiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
Quantitative analyses of G protein activation by the single molecule imaging
- Principal Investigator
  
  TATEYAMA Michihiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
膜電位センサーを持たないATP受容体チャネルの膜電位依存性ゲーティングの分子基盤Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
ATP受容体チャネルP2Xの発現状況に依存する構造と機能の変化の解析Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
膜電位-細胞長変換素子プレスチンの分子構築と動的構造変化Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
Molecular identification and functional analysis of a caffeine receptor on the plasma membrane.Principal Investigator
- Principal Investigator
  
  KUBO Yoshihiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
外有毛細胞蛋白プレスチンの膜電位-細胞長変換の分子機構及び膜機能蛋白との機能協関Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
イオンチヤネル・受容体群の「膜上直接相互作用」によるシナプス伝達の調節機構Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
イオンチャネル・受容体群の「膜上直接的相互作用」によるシナプス伝達の調節機構Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
グルタミン酸・ATPによる情報伝達新規調節機構の受容体ノックインマウスによる解析Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
Dynamic structural rearrangements of ion channels and receptors dependent on expression density.Principal Investigator
- Principal Investigator
  
  KUBO Yoshihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
代謝型グルタミン酸受容体の機能修飾機構と活性化に伴う動的構造変化の解析Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
  Tokyo Medical and Dental University
刺激依存的に細胞膜に移行するGタンパク共役系調節因子群のプロテオーム解析
- Principal Investigator
  
  SAITOH Osamu
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
新規高分子量G蛋白質の神経細胞内動態とシナプス関連蛋白との機能協関Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
開状態におけるイオンチャネルポアの柔軟性の分子基盤Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University
代謝型グルタミン酸受容体の分子構築と機能制御機構の解明Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
海馬神経細胞に高発現する新規高分子量G蛋白質のシナプス関連膜蛋白との機能的協関Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Functional analyses of the mouse mitochondrial GTPase, mOPAI. -identification of binding proteins and subcellular localization -Principal Investigator
- Principal Investigator
  
  KUBO Yoshihiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University
代謝型グルタミン酸受容体の分子構築と機能制御機構の解明Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
新規高分子量GTP総合蛋白質の細胞内局在の動態と細胞生理学的機能の解析Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University
Towards the dynamic changes of the structure and interaction of ion channels and receptors, -Analysis by Fluorescence Resonance Energy Transfer method-Principal Investigator
- Principal Investigator
  
  KUBO Yoshihiro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University graduate School
代謝型グルタミン酸受容体の細胞外カルシウム感知機能がシナプスの可塑性に果たす役割Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
  Tokyo Metropolitan Organization for Medical Research
イオンチャネルの分子内構造変化と分子間相互作用の光学的新手法による解析の試みPrincipal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
内向き整流性K+チャネルの動的構造機能連関の新しい電気変手法による解析Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
Physiological Significance of the extracellular Ca2+ Sensitivity of the Metabotropic Glutamate ReceptorPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshihiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  神経・脳内生理学
- Research Institution
  Tokyo Medical and Dental Inversity graduate School
  Tokyo Metropolitan Organization for Medical Research
  Tokyo Metropolitan Institute for Neuroscience
細胞外K^+イオンによる内向き整流性K^+チャネルの活性化機構の解明Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
細胞外カルシウムとグルタミン酸により活性化される代謝型受容体の生理的機能の解明Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  神経・脳内生理学
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
細胞外K^+イオンによる内向き整流性K^+チャネルの活性化機構の解明Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
性質の異なる2つの内向己整流性K^Tチャネルのキメラを用いた諸機能部位の同定Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
内向き整流性ポタシウムの内向き整流性を決定する分子基盤の解明Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
単クローン抗体による内向き整流性ポタシウムチャネルの組織内分布と細胞内分布の解析Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
内向き整流性ポタシウムチャネルの構造機能連関の分子生物学的解析Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
各筋分化決定遺伝子と、筋分化初期過程の電気生理学的特質の対応の解析Principal Investigator
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
PIONEERING RESEARCH ON THE DYNAMICAL ASPECT OF STRUCTURE-FUNTION RELATIONSHIP IN ION CHANNELS
- Principal Investigator
  
  SOKABE Masahiro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University
Comparative studies on early neural-type differentiation between isolated blastomeres of protochordate embryos and teratocarcinoma cell lines derived from mouse primitive ectoderm.
- Principal Investigator
  
  TAKAHASHI Kunitaro
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  The University of Tokyo

[Book] トランスポトソームの世界-膜輸送研究の源流から未来へ2011
- Author(s)
  金井好克、竹島浩、森泰生、久保義弘(編著)
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-20390062
[Book] トランスポトソームの世界-膜輸送研究の源流から未来へ2011
- Author(s)
  金井好克、竹島浩、森泰生、久保義弘(編著)
- Total Pages
  471
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-21659053
[Book] Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition, Structural rearrangement and functional relation of the metabotropic glutamate receptor2009
- Author(s)
  Kubo Y., Tateyama M
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] A self-inactivating invertebrate opsin optically drives biased signaling toward Gβγ-dependent ion channel modulation2023
- Author(s)
  Tsukamoto Hisao、Kubo Yoshihiro
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 21
- DOI
  10.1073/pnas.2301269120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21296, KAKENHI-PROJECT-23K27358
[Journal Article] Conformational rearrangements in the second voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels2023
- Author(s)
  Shimomura T, Hirazawa K, Kubo Y
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 120(6) Issue: 6
- DOI
  10.1073/pnas.2209569120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03424, KAKENHI-PROJECT-20K07284, KAKENHI-PUBLICLY-22H04758
[Journal Article] Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors2023
- Author(s)
  Tateyama M. and Kubo Y
- Journal Title
  
  PLOS　ONE
  
  Volume: 18 Issue: 4 Pages: e0284962-e0284962
- DOI
  10.1371/journal.pone.0284962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06793, KAKENHI-PROJECT-23K27358
[Journal Article] Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV12023
- Author(s)
  Shogo Hori, Michihiro Tateyama, Tsuyoshi Shirai, Yoshihiro Kubo, Osamu Saitoh
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 2415-2415
- DOI
  10.1038/s41467-023-38051-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06324, KAKENHI-PROJECT-21K06793, KAKENHI-PROJECT-23K21721, KAKENHI-PROJECT-23K27358
[Journal Article] Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific2022
- Author(s)
  Brake N, Mancino AS, Yan Y, Shimomura T, Kubo Y, Khadra A, Bowie D
- Journal Title
  
  J Gen Physiol
  
  Volume: 154(7) Issue: 7
- DOI
  10.1085/jgp.202112921
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03424, KAKENHI-PROJECT-20K07284, KAKENHI-PUBLICLY-22H04758
[Journal Article] A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K + channel2022
- Author(s)
  Chen IS, Eldstrom J, Fedida D, Kubo Y.
- Journal Title
  
  Journal of Physiology
  
  Volume: 600 Issue: 3 Pages: 603-622
- DOI
  10.1113/jp282430
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03424, KAKENHI-PROJECT-20K07304
[Journal Article] Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization2021
- Author(s)
  Matsumura Kazuki、Shimomura Takushi、Kubo Yoshihiro、Oka Takayuki、Kobayashi Naohiro、Imai Shunsuke、Yanase Naomi、Akimoto Madoka、Fukuda Masahiro、Yokogawa Mariko、Ikeda Kazuyoshi、Kurita Jun-ichi、Nishimura Yoshifumi、Shimada Ichio、Osawa Masanori
- Journal Title
  
  BMC Molecular and Cell Biology
  
  Volume: 22 Issue: 1 Pages: 1-16
- DOI
  10.1186/s12860-020-00337-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07284, KAKENHI-PUBLICLY-19H04973, KAKENHI-PUBLICLY-20H05449, KAKENHI-PROJECT-20H03424, KAKENHI-PROJECT-18K06152, KAKENHI-PROJECT-18K06606, KAKENHI-PROJECT-17H06097
[Journal Article] Phosphoinositide regulates dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 32021
- Author(s)
  Hirazawa Kiichi、Tateyama Michihiro、Kubo Yoshihiro、Shimomura Takushi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297 Issue: 6 Pages: 101425-101425
- DOI
  10.1016/j.jbc.2021.101425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05449, KAKENHI-PROJECT-20H03424, KAKENHI-PROJECT-20K07284, KAKENHI-PROJECT-21K06793
[Journal Article] Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization2021
- Author(s)
  Andriani R, Kubo Y.
- Journal Title
  
  Elife
  
  Volume: 10
- DOI
  10.7554/elife.65822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03424
[Journal Article] Functional properties of axolotl transient receptor potential ankyrin 1 revealed by the heterologous expression system2019
- Author(s)
  Oda M, Ogino H, Kubo Y, Saitoh O
- Journal Title
  
  Neuroreport
  
  Volume: 30 Issue: 5 Pages: 323-330
- DOI
  10.1097/wnr.0000000000001197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-16K07305, KAKENHI-PROJECT-16H04794
[Journal Article] Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels.2019
- Author(s)
  Chen IS, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y
- Journal Title
  
  Br J Pharmacol
  
  Volume: 176 Issue: 17 Pages: 3161-3179
- DOI
  10.1111/bph.14717
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-18K15020
[Journal Article] Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A72019
- Author(s)
  Ishii Jun、Suzuki Atsushi、Kimura Toru、Tateyama Michihiro、Tanaka Tatsushi、Yazawa Takuya、Arimasu Yu、Chen I-Shan、Aoyama Kohei、Kubo Yoshihiro、Saitoh Shinji、Mizuno Haruo、Kamma Hiroshi
- Journal Title
  
  Communications Biology
  
  Volume: 2 Issue: 1 Pages: 1-11
- DOI
  10.1038/s42003-019-0503-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15723, KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-17K08557
[Journal Article] Phosphoinositides modulate the voltage dependence of two-pore channel 32019
- Author(s)
  Shimomura T, Kubo Y
- Journal Title
  
  J Gen Physiol
  
  Volume: 151 Issue: 8 Pages: 986-1006
- DOI
  10.1085/jgp.201812285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-18K15019
[Journal Article] Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.2018
- Author(s)
  Chen IS, Kubo Y.
- Journal Title
  
  J Physiol
  
  Volume: 印刷中 Issue: 10 Pages: 1833-1845
- DOI
  10.1113/jp275236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-16K18999
[Journal Article] SLO potassium channels antagonize premature decision making in C. elegans2018
- Author(s)
  Aoki I, Tateyama M, Shimomura T, Ihara K, Kubo Y, Nakano S, Mori I.
- Journal Title
  
  Commun Biol.
  
  Volume: 1 Issue: 1 Pages: 123-123
- DOI
  10.1038/s42003-018-0124-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07267, KAKENHI-PROJECT-17K07499, KAKENHI-PROJECT-17K08557, KAKENHI-PUBLICLY-18H04693, KAKENHI-PUBLICLY-18H05123, KAKENHI-WRAPUP-18H05199, KAKENHI-PROJECT-16H02516, KAKENHI-PROJECT-17H04021
[Journal Article] Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation.2018
- Author(s)
  Tateyama M, Kubo Y
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 9 Pages: e0204447-e0204447
- DOI
  10.1371/journal.pone.0204447
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-17H04021
[Journal Article] Structural properties determining low K+affinity of the selectivity filter in the TWIK1 K+channel2018
- Author(s)
  Tsukamoto Hisao、Higashi Masahiro、Motoki Hideyoshi、Watanabe Hiroki、Ganser Christian、Nakajo Koichi、Kubo Yoshihiro、Uchihashi Takayuki、Furutani Yuji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 18 Pages: 6969-6984
- DOI
  10.1074/jbc.ra118.001817
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0165, KAKENHI-PROJECT-17K05757, KAKENHI-PROJECT-17K08552, KAKENHI-PROJECT-17K15109, KAKENHI-PROJECT-26708002, KAKENHI-PUBLICLY-16H00758, KAKENHI-PUBLICLY-16H00778, KAKENHI-PUBLICLY-16H00830, KAKENHI-PROJECT-15H03540, KAKENHI-PROJECT-17H04021
[Journal Article] Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain.2018
- Author(s)
  Kume S, Shimomura T, Tateyama M, Kubo Y
- Journal Title
  
  Journal of Physioloby
  
  Volume: 596 Issue: 19 Pages: 4629-4650
- DOI
  10.1113/jp276208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-17H04021
[Journal Article] Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ-independent manner and an amino acid residue at the slide helix governs the activation.2017
- Author(s)
  Chen, I.S., Tateyama, M., Fukata, Y., Uesugi, M., & Kubo, Y.
- Journal Title
  
  Journal of Physiology
  
  Volume: 595 Issue: 17 Pages: 5895-5912
- DOI
  10.1113/jp274871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-15H04279, KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-16K18999
[Journal Article] Stabilizing effects of G protein on the active conformation of adenosine A1 receptor differ depending on G protein type2016
- Author(s)
  Tateyama M, Kubo Y
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 788 Pages: 122-131
- DOI
  10.1016/j.ejphar.2016.06.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293044, KAKENHI-PROJECT-26460307
[Journal Article] Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial temporal lobe epilepsy.2015
- Author(s)
  Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M
- Journal Title
  
  Nat Med
  
  Volume: 21 Issue: 1 Pages: 19-26
- DOI
  10.1038/nm.3759
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-24108007, KAKENHI-PUBLICLY-25110733, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-25890021, KAKENHI-PROJECT-26291045, KAKENHI-PROJECT-26460250, KAKENHI-PROJECT-24220007
[Journal Article] Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial2015
- Author(s)
  Aoki Y, Watanabe T, Abe O, Kuwabara H, Yahata N, Takano Y, Iwashiro N, Natsubori T, Takao H, Kawakubo Y, Kasai K, Yamasue H
- Journal Title
  
  Mol Psychiatry
  
  Volume: 20 Issue: 4 Pages: 447-53
- DOI
  10.1038/mp.2014.74
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461751, KAKENHI-PROJECT-26250024, KAKENHI-PROJECT-26670535, KAKENHI-PROJECT-221S0003
[Journal Article] Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans2014
- Author(s)
  Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, Yokota K, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S
- Journal Title
  
  Science Translational Medicine
  
  Volume: 6 Issue: 256 Pages: 256-256
- DOI
  10.1126/scitranslmed.3009430
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J00745, KAKENHI-PROJECT-14J01375, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23229008, KAKENHI-PUBLICLY-25110725, KAKENHI-PLANNED-25116010, KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-25460721, KAKENHI-PROJECT-25670662, KAKENHI-PROJECT-25713053, KAKENHI-PROJECT-26290064, KAKENHI-PROJECT-26861198
[Journal Article] Immunostaining of oxidized DJ-1 in human and mouse brains.2014
- Author(s)
  Saito, Y., T. Miyasaka, H. Hatsuta, K. Takahashi-Niki, K. Hayashi, Y. Mita, O. Kusano-Arai, H. Iwanari, H. Ariga, T. Hamakubo, Y. Yoshida, E. Niki, S. Murayama, Y. Ihara and N. Noguchi
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 73 Issue: 7 Pages: 714-728
- DOI
  10.1097/nen.0000000000000087
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-24790773, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-25670084
[Journal Article] Analyses of the effects of Gq protein on the activated states of the muscarinic M3 receptor and the purinergic P2Y1 receptor2013
- Author(s)
  Tateyama M, Kubo Y
- Journal Title
  
  Physiological Reports
  
  Volume: 1(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390045
[Journal Article] Analyses of the effects of Gq protein on the activated states of the muscarinic M3 receptor and the purinergic P2Y1 receptor2013
- Author(s)
  Tateyama M and Kubo Y
- Journal Title
  
  Physiological Reports
  
  Volume: 1(5) Issue: 5
- DOI
  10.1002/phy2.134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390045, KAKENHI-PROJECT-23590270
[Journal Article] In vivo optogenetic tracing of functional corticocorticai connections between motor forelimb areas2013
- Author(s)
  Hira R, Ohkubo F, Tanaka YR, Masamizu Y, Augustine GJ, Kasai H, Matsuzaki M
- Journal Title
  
  Frontiers in Neural Circuits
  
  Volume: 7 Pages: 55-55
- DOI
  10.3389/fncir.2013.00055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00136, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23300148, KAKENHI-PROJECT-23800071, KAKENHI-PLANNED-22115005
[Journal Article] Binding of Gq protein stabilizes the activated state of the muscarinic receptor type 12013
- Author(s)
  Tateyama, M., Kubo, Y
- Journal Title
  
  Neuropharmacol.
  
  Volume: 65 Pages: 173-183
- DOI
  10.1016/j.neuropharm.2012.10.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590270
[Journal Article] Binding of Gq protein stabilizes the activated state of the muscarinic receptor type 12013
- Author(s)
  Tateyama M, Kubo Y
- Journal Title
  
  Neuropharmacology
  
  Volume: 65 Pages: 173-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390045
[Journal Article] Spatiolemporal dynamics of functional clusters of neurons in mouse motor corlex during a voluntary movement2013
- Author(s)
  Hira R, Okubo F, Ozawa K, Isomura Y, KHamura K, Kano M, Kasai H, Matsuzaki M
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 33 Issue: 4 Pages: 1377-90
- DOI
  10.1523/jneurosci.2550-12.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00136, KAKENHI-PROJECT-21000009, KAKENHI-PROJECT-21220006, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-22680031, KAKENHI-PROJECT-23650204, KAKENHI-PROJECT-24300143, KAKENHI-PUBLICLY-23115504, KAKENHI-PUBLICLY-24120715
[Journal Article] GABA_B受容体の構造と機能2012
- Author(s)
  立山充博, 松下真一, 久保義弘
- Journal Title
  
  臨床神経科学(中外医学社)
  
  Volume: 30巻第12号 Pages: 1349-1351
- Data Source
  KAKENHI-PROJECT-23590270
[Journal Article] GABAB受容体の構造と機能2012
- Author(s)
  立山充博、松下真一、久保義弘
- Journal Title
  
  臨床神経科学
  
  Volume: 30 Pages: 1349-1351
- Data Source
  KAKENHI-PROJECT-23590270
[Journal Article] The intra-molecular activation mechanisms of the dimeric metabotropic glutamate receptor 1 differ depending on the type of G proteins2011
- Author(s)
  Tateyama, M., Kubo, Y
- Journal Title
  
  Neuropharmacol.
  
  Volume: 61 Issue: 4 Pages: 832-841
- DOI
  10.1016/j.neuropharm.2011.05.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590270
[Journal Article] KCNQ1 subdomains involved in KCNE Modulation revealed by an invertebrate KCNQ1 orthologue2011
- Author(s)
  Nakajo K, Nishino A, Okamura Y, Kubo Y
- Journal Title
  
  J Gen Physiol
  
  Volume: 138 Pages: 521-535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390045
[Journal Article] KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue2011
- Author(s)
  Nakajo K, Nishino A, Okamura Y, Kubo Y
- Journal Title
  
  Journal of General Physiology
  
  Volume: 138 Pages: 521-535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390045
[Journal Article] Nano-environmental changes by KCNE proteins modify KCNQ channel function2011
- Author(s)
  Nakajo K, Kubo Y
- Journal Title
  
  Channels
  
  Volume: 5 Pages: 397-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390045
[Journal Article] The intra-molecular activation mechanisms of the dimeric metabotropic glutamate receptor 1 differ depending on the type of G proteins2011
- Author(s)
  Tateyama M, Kubo Y
- Journal Title
  
  Neuropharmacology
  
  Volume: 61 Pages: 832-841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390045
[Journal Article] Stoichiometry of the KCNQ1-KCNE1 ion channel complex2010
- Author(s)
  Nakajo K, Ulbrich M, Kubo Y, Isacoff E.
- Journal Title
  
  Proceedings of the National Academy of Sciences, U.S.A.
  
  Volume: 107 Pages: 18862-18867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Ligand-induced rearrangements of the GABAB receptor revealed by fluorescence resonance energy transfer.2010
- Author(s)
  Matsushita S, Nakata H, Tateyama M, Kubo Y
- Journal Title
  
  Journal of Biological Chemistry 285
  
  Pages: 10291-10299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] G蛋白質共役型受容体の構造変化の全反射照明下FRET法による解析2010
- Author(s)
  久保義弘、立山充博
- Journal Title
  
  医学の歩み最新G蛋白質共役受容体研究
  
  Volume: 233 Pages: 699-703
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] G蛋白質共役型受容体の構造変化の全反射照明下FRET法による解析2010
- Author(s)
  久保義弘、立山充博
- Journal Title
  
  医学の歩み(医歯薬出版株式会社) 233巻第9号
  
  Pages: 699-703
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] Ligand-induced rearrangements of the GABAB receptor revealed by fluorescence resonance energy transfer2010
- Author(s)
  Matsushita, S., Nakata, H.Kubo, Y., Tateyama, M.
- Journal Title
  
  Journal of Biological Chemistry 285
  
  Pages: 10291-10299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] G蛋白質共役受容体の構造変化の全反射照明下FRET法による解析2010
- Author(s)
  久保義弘、立山充博
- Journal Title
  
  医学の歩み
  
  Volume: 233 Pages: 699-703
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] A mammalian neural tissue opsin (Opsin 5) is a deep brain photo-receptor in birds.2010
- Author(s)
  Nakane Y, Ikegami K, Ono H, Yamamoto N, Yoshida S, Hirunagi K, Ebihara S, Kubo Y, Yoshimura T
- Journal Title
  
  Proceedings of the National Academy of Sciences, USA. 107
  
  Pages: 18862-18867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Ligand-induced rearrangements of the GABAB receptor revealed by fluore scence resonance energy transfer2010
- Author(s)
  Matsushita S, Nakata H, Tateyama M, Kubo Y
- Journal Title
  
  Journal of Biological Chemistry 285
  
  Pages: 10291-10299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Identification and characterization of Cs+-permeable K+ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation.2010
- Author(s)
  Ishii H, Nakajo K, Yanagawa Y, Kubo Y
- Journal Title
  
  European Journal of Neuroscience 32
  
  Pages: 736-748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] G蛋白質共役受容体の構造変化の全反射照明下FRET法による解析医学の歩み2010
- Author(s)
  久保義弘、立山充博
- Journal Title
  
  G蛋白質共役受容体研究(飯利太朗編) 233
  
  Pages: 699-703
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] A mammalian neural tissue opsin(Opsin 5)is a deep brain photoreceptor in birds.2010
- Author(s)
  Nakane Y, Ikegami K, Ono H, Yamamoto N, Yoshida S, Hirunagi K, Ebihara S, Kubo Y, Yoshimura T.
- Journal Title
  
  Proceedings of the National Academy of Sciences, U.S.A.
  
  Volume: 107 Pages: 15264-15268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Identification and characterization of Cs^+-permeable K^+ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation.2010
- Author(s)
  Ishii H, Nakajo K, Yanagawa Y, Kubo Y.
- Journal Title
  
  European Journal of Neuroscience
  
  Volume: 32 Pages: 736-748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Ligand-induced rearrangements of the GABAB receptor revealed by fluorescence resonance energy transfer2010
- Author(s)
  Matsushita S, Nakata H, Tateyama M, Kubo Y
- Journal Title
  
  Journal of Biological Chemistry 285
  
  Pages: 10291-10299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20056031
[Journal Article] Ligand-induced rearrangements of the GABAB receptor revealed by fluorescence resonance energy transfer.2010
- Author(s)
  Matsushita S., Nakata H., Kubo Y., Tateyama M.
- Journal Title
  
  J.Biol.Chem. 285
  
  Pages: 10291-10299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] The Met268 Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression.2010
- Author(s)
  Nagatomo K, Ishii H, Yamamoto T, Nakajo K.Kubo Y
- Journal Title
  
  Biophysical Journal
  
  Volume: 99 Pages: 3609-3618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659053
[Journal Article] Effects of spinophilin on the function of RGS8 regulating signals from M2 and M3- mAChRs.2009
- Author(s)
  Kurogi M, Nagatomo K, Kubo Y, Saitoh O
- Journal Title
  
  Neuroreport 20
  
  Pages: 1134-1139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Voltage- and [ATP]-dependent gating of the P2X_2 ATP receptor channel2009
- Author(s)
  Fujiwara Y, Keceli B, Nakajo K, Kubo Y.
- Journal Title
  
  Journal of General Physiology 133
  
  Pages: 93-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659053
[Journal Article] Reconstruction of the P2X2 receptor revealed a vase-shaped structure with lateral tunnels above the membrane2009
- Author(s)
  Mio K, Ogura T, Yamamoto T, Hiroaki Y, Fujiyoshi Y, Kubo Y and Sato C.
- Journal Title
  
  Structure 17
  
  Pages: 266-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20056031
[Journal Article] Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage-and[ATP]-dependent gating2009
- Author(s)
  Keceli B, Kubo Y
- Journal Title
  
  Journal of Physiology 587
  
  Pages: 5801-5818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Structural rearrangements of the motor protein prestin revealed by fluorescence resonance energy transfer.2009
- Author(s)
  Gleitsman KR, Tateyama M., Kubo Y.
- Journal Title
  
  Am.J.Physiol.Cell Physiol. 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] Structural rearrangements of the motor protein prestin revealed by fluorescence resonance energy transfer2009
- Author(s)
  Gleitsman KR, Tateyama M, Kubo Y
- Journal Title
  
  American Journal of Physiology Cell Physiology 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659053
[Journal Article] Functional & structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage- and [ATP]- dependent gating.2009
- Author(s)
  Keceli B, Kubo Y
- Journal Title
  
  Journal of Physiology 587
  
  Pages: 5801-5818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage-and[ATP]-dependent gating2009
- Author(s)
  Keceli B, Kubo Y
- Journal Title
  
  Journal of Physiology 587
  
  Pages: 5801-5818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659053
[Journal Article] Reconstruction of the P2X2 receptor revealed a vase-shaped structure with lateral tunnels above the membrane2009
- Author(s)
  Mio K, Ogura T, Yamamoto T, Hiroaki Y, Fujiyoshi Y, Kubo Y, Sato C.
- Journal Title
  
  Structure 17
  
  Pages: 266-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659053
[Journal Article]2009
- Author(s)
  Kubo, Y., Tateyama M
- Journal Title
  
  Structural rearrangement and functional relation of the metabotropic glutamate receptor. in Handbook of Neurochemistry and Molecular Neurobiology.3rd Edition(Springer)
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] Effects of spinophilin on the function of RGS8 regulating signals from M2 and M3-mAChRs2009
- Author(s)
  Kurogi M, Nagatomo K, Kubo Y, Saitoh O
- Journal Title
  
  Neuroreport 20
  
  Pages: 1134-1139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Voltage-and [ATP]-dependent gating of the P2X2 ATP receptor channel2009
- Author(s)
  Fujiwara Y, Keceli B, Nakajo K and Kubo, Y.
- Journal Title
  
  Journal of General Physiology 133
  
  Pages: 93-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20056031
[Journal Article] Structural rearrangements of the motor protein prestin revealed by fluorescence resonance energy transfer2009
- Author(s)
  Gleitsman KR, Tateyama M, Kubo Y
- Journal Title
  
  American Journal of Physiology Cell Physiology 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20056031
[Journal Article] Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage- and [ATP]-dependent gating2009
- Author(s)
  Keceli B, Kubo Y
- Journal Title
  
  Journal of Physiology 587
  
  Pages: 5801-5818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20056031
[Journal Article] Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels2008
- Author(s)
  Nagatomo K, Kubo Y.
- Journal Title
  
  Proceedings of the National Academy of Sciences, USA 105
  
  Pages: 17373-17378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Sphinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8.2008
- Author(s)
  Fujii S, Yamazoe G, Itoh M, Kubo Y, Saitoh O
- Journal Title
  
  Biochemical and Biophysical Research Communications 377
  
  Pages: 200-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Regulatory role of C-terminus in the G protein coupling of the metabotropic glutamate receptor 1.2008
- Author(s)
  立山充博, 久保義弘
- Journal Title
  
  J.Neurochem. 107
  
  Pages: 1036-1046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels.2008
- Author(s)
  Nagatomo K, Kubo Y
- Journal Title
  
  Proceedings of the National Academy of Sciences, USA 105
  
  Pages: 17373-17378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Regulatory role of C-terminus in the G protein coupling of the metabotropic glutamate receptor 12008
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Journal of Neurochemistry 107
  
  Pages: 1036-1046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] The motor protein prestin is a bullet-shaped molecule with inner Cavities2008
- Author(s)
  Mio K, Kubo Y, Ogura T, Yamamoto T, Arisaka F, Sato C
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 1137-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] The motor protein prestin is a bullet-shaped molecule with inner Cavities.2008
- Author(s)
  Mio K, Kubo Y, Ogura T, Yamamoto T, Arisaka F and Sato C
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 1137-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18022042
[Journal Article] Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels2008
- Author(s)
  Nagatomo K, Kubo Y.
- Journal Title
  
  Proceedings of the National Academy of Sciences, USA 105
  
  Pages: 17373-17378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659053
[Journal Article] The motor protein prestin is a bullet-shaped molecule with inner Cavities.2008
- Author(s)
  Mio K, Kubo Y, Ogura T, Yamamoto T, Arisaka F, Sato C
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 1137-1145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Sphinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS82008
- Author(s)
  Fujii S, Yamazoe G, Itoh M, Kubo Y, Saitoh O
- Journal Title
  
  Biochemical and Biophysical Research Communications 377
  
  Pages: 200-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Regulatory role of C-terminus in the G protein coupling of the metabotropic glutamate receptorl2008
- Author(s)
  Tateyama M, Kubo Y
- Journal Title
  
  Journal of Neurochemistry 107
  
  Pages: 1036-1046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] Regulatory role of C-terminus in the G protein coupling of the metabotropic glutamate receptor1.2008
- Author(s)
  Tateyama M, Kubo Y
- Journal Title
  
  Journal of Neurochemistry 107
  
  Pages: 1036-1046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390062
[Journal Article] The motor protein prestin is a bullet-shaped molecule with inner Cavities2008
- Author(s)
  Mio K, Kubo Y, Ogura T, Yamamoto T, Arisaka F and Sato C
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 1137-1145
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] The motor protein prestin is a bullet-shaped molecule with inner Cavities.2008
- Author(s)
  Mio K, Kubo Y, Ogura T, Yamamoto T, Arisaka F and Sato C
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 1137-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18059033
[Journal Article] Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels2008
- Author(s)
  Nagatomo, K. and Kubo, Y.
- Journal Title
  
  Proceedings of the National Academy of Sciences, USA 105
  
  Pages: 17373-17378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20056031
[Journal Article] The motor protein prestin is a bullet-shaped molecule with inner Cavities2008
- Author(s)
  Mio K, Kubo Y, Ogura T, Yamamoto T, Arisaka F and Sato C
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 1137-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659053
[Journal Article] Coupling profile of the metabotropic glutamate receptor 1□ is regulated by the C-terminal domain.2007
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Molecular and Cellular Neuroscience 34
  
  Pages: 445-452
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] KCNE1 and KCNE3 Stabilize and/or Slow Vbltage Sensing S4 Segment of KCNQ1 Channel.2007
- Author(s)
  Nakajo K and Kubo Y
- Journal Title
  
  Journal of General Physiology 130
  
  Pages: 269-281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18059033
[Journal Article] Coupling profile of the metabotropic glutamate receptor 1α is regulated by the C-terminal domain2007
- Author(s)
  Tateyama M and Kubo Y
- Journal Title
  
  Molecular and Cellular Neuroscience 34
  
  Pages: 445-452
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] KCNE1 and KCNE3 Stabilize and/or Slow Voltage Sensing S4 Segment of KCNQ1 Channel2007
- Author(s)
  Nakajo K and Kubo Y
- Journal Title
  
  Journal of General Physiology 130
  
  Pages: 269-281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659053
[Journal Article] KCNE1 and KCNE3 Stabilize and/or Slow Voltage Sensing S4 Segment of KCNQ1 Channel.2007
- Author(s)
  Nakajo K, Kubo Y
- Journal Title
  
  Journal of General Physiology 130
  
  Pages: 269-281
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Coupling profile of the metabotropic glutamate receptor 1□ is regulated by the C-terminal domain.2007
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Molecular and Cellular Neuroscience 34
  
  Pages: 445-452
- Data Source
  KAKENHI-PROJECT-18022042
[Journal Article] Coupling profile of the metabotropic glutamate receptor 1□is regulated by the C-terminal domain.2007
- Author(s)
  Tateyama M, Kubo Y
- Journal Title
  
  Molecular and Cellular Neuroscience 34
  
  Pages: 445-452
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] KCNEI and KCNE3 Stabilize and/or Slow Voltage Sensing S4 Segment of KCNQ1 Channel2007
- Author(s)
  Nakajo K, Kubo Y
- Journal Title
  
  Journal of General Physiology 130
  
  Pages: 269-281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Coupling profile of the metabotropic glutamate receptor 1□ is regulated by the C-terminal domain.2007
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Molecular and Cellular Neuroscience 34
  
  Pages: 445-452
- Data Source
  KAKENHI-PROJECT-18059033
[Journal Article] KCNE1 and KCNE3 Stabilize and/or Slow Voltage Sensing S4 Segment of KCNQ1 Channel.2007
- Author(s)
  Nakajo K and Kubo Y
- Journal Title
  
  Journal of General Physiology 130
  
  Pages: 269-281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18022042
[Journal Article] KCNE1 and KCNE3 Stabilize and/or Slow Voltage Sensing S4 Segment of KCNQ1 Channel2007
- Author(s)
  Nakajo K and Kubo Y
- Journal Title
  
  Journal of General Physiology 130
  
  Pages: 269-281
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Alternative splicing of RGS8 gene changes the binding property to the M1 muscarinic receptor to confer receptor type-specific Go regulation.2006
- Author(s)
  Itoh, M., Nagatomo, K., Kubo, Y., Saitoh, O.
- Journal Title
  
  Journal of Neurochemistry 99
  
  Pages: 1505-1516
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.2006
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of General Physiology 127
  
  Pages: 401-419
- Data Source
  KAKENHI-PROJECT-18059033
[Journal Article] Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.12006
- Author(s)
  Fujiwara Y and Kubo Y
- Journal Title
  
  Journal of General Physiology 127
  
  Pages: 401-419
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Regulation of the desensitization and ion selectivity of ATP-gated P2X_2 channels by phosphoinositides.2006
- Author(s)
  Fujiwara Y, Kubo Y
- Journal Title
  
  Journal of Physiology 576
  
  Pages: 135-149
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.2006
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of General Physiology 127
  
  Pages: 401-419
- Data Source
  KAKENHI-PROJECT-18022042
[Journal Article] Dimeric rearrangement and multiple signaling of metaobotropic glutamate receptor.2006
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Cell Technology 25
  
  Pages: 247-250
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Regulation of the desensitization and ion selectivity of ATP-gated P2X_2 channels by phosphoinositides.2006
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of Physiology 576
  
  Pages: 135-149
- Data Source
  KAKENHI-PROJECT-18059033
[Journal Article] Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.2006
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of General Physiology (印刷中)
- Data Source
  KAKENHI-PROJECT-16047205
[Journal Article] Regulation of the desensitization and ion selectivity of ATP-gated P2X_2 channels by phosphoinositides.2006
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of Physiology 576
  
  Pages: 135-149
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Alternative splicing of RGS8 gene changes the binding property to the Ml muscarinic receptor to confer receptor type-specific Gq regulation.2006
- Author(s)
  Itoh M, Nagatomo K, Kubo Y, Saitoh O
- Journal Title
  
  Journal of Neurochemistry 99
  
  Pages: 1505-1516
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.2006
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of General Physiology (印刷中)
- Data Source
  KAKENHI-PROJECT-17024058
[Journal Article] Alternative splicing of RGS8 gene changes the binding property to the M1 muscarinic receptor to confer receptor type-specific Gq regulation.2006
- Author(s)
  Itoh, M., Nagatomo, K., Kubo, Y., Saitoh, O.
- Journal Title
  
  Journal of Neurochemistry 99
  
  Pages: 1505-1516
- Data Source
  KAKENHI-PROJECT-18022042
[Journal Article] Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor1a.2006
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 103
  
  Pages: 1124-1128
- Data Source
  KAKENHI-PROJECT-16047205
[Journal Article] Dual signaling is differentially activated by different active states of the metabotropic glutamate receptorla.2006
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 103
  
  Pages: 1124-1128
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor1a.2006
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 103
  
  Pages: 1124-1128
- Data Source
  KAKENHI-PROJECT-16659053
[Journal Article] Regulation of the desensitization and ion selectivity of ATP-gated P2X_2 channels by phosphoinositides.2006
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of Physiology 576
  
  Pages: 135-149
- Data Source
  KAKENHI-PROJECT-18022042
[Journal Article] Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor1a.2006
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 103
  
  Pages: 1124-1128
- Data Source
  KAKENHI-PROJECT-17024058
[Journal Article] Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.2006
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of General Physiology 127
  
  Pages: 401-419
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor1a.2006
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 103
  
  Pages: 1124-1128
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.2006
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of General Physiology (印刷中)
- Data Source
  KAKENHI-PROJECT-16659053
[Journal Article] Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.2006
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of General Physiology (印刷中)
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] 代謝型グルタミン酸受容体の動的構造変化とシグナリングの多様性2006
- Author(s)
  立山充博, 久保義弘
- Journal Title
  
  細胞工学 25
  
  Pages: 247-250
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor1α.2006
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 103
  
  Pages: 1124-1128
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.2006
- Author(s)
  Fujiwara Y, Kubo Y
- Journal Title
  
  Journal of General Physiology 127
  
  Pages: 401-419
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Regulation of the desensitization and ion selectivity of ATP-gated P2X_2 channels by phosphoinositides2006
- Author(s)
  Fujiwara Y and Kubo Y
- Journal Title
  
  Journal of Physiology 576
  
  Pages: 135-149
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Alternative splicing of RGS8 gene changes the binding property to the M1 muscarinic receptor to confer receptor type-specific Gq regulation.2006
- Author(s)
  Itoh, M., Nagatomo, K., Kubo, Y., Saitoh.O.
- Journal Title
  
  Journal of Neurochemistry 99
  
  Pages: 1505-1516
- Data Source
  KAKENHI-PROJECT-18059033
[Journal Article] Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.2006
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of General Physiology 127
  
  Pages: 401-419
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Alternative splicing of RGS8 gene changes the binding property to the M1 muscarinic receptor to confer receptor type-specific Gq regulation2006
- Author(s)
  Itoh M, Nagatomo K, Kubo Y and Saitoh O
- Journal Title
  
  Journal of Neurochemistry 99
  
  Pages: 1505-1516
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Towards a view of functioning dimeric metabotropic receptors2005
- Author(s)
  Kubo, Y, Tateyama, M.
- Journal Title
  
  Current Opinion in Neurobiology 57
  
  Pages: 509-526
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] OPA1 expression in the normal rat retina and optic nerve.2005
- Author(s)
  Ju, W.K., Misaka, T., Kushnareva, Y., Nakagomi, S, Agarwal, N., Kubo, Y.et al.
- Journal Title
  
  Journal of Comparative Neurology 488
  
  Pages: 1-10
- Data Source
  KAKENHI-PROJECT-16659053
[Journal Article] Visualization of the trimeric P2X2 receptor with a crown-capped extracellular domain.2005
- Author(s)
  Mio, K., Kubo, Y., Ogura, T., Yamamoto, T., Sato, C.
- Journal Title
  
  Biochemical and Biophysical Research Communications 337
  
  Pages: 998-1005
- Data Source
  KAKENHI-PROJECT-16047205
[Journal Article] Structure-function relationship and channelopathy of inward rectifier potassium channel IRK1.2005
- Author(s)
  Kubo, Y., Fujiwara, Y.
- Journal Title
  
  Igaku-no-Ayumi Suppl. 215
  
  Pages: 88-93
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Visualization of the trimeric P2×2 receptor with a crown-capped extracellular domain.2005
- Author(s)
  Mio, K., Kubo, Y., Ogura, T., Yamamoto, T., Sato, C.
- Journal Title
  
  Biochemical and Biophysical Research Communications 337
  
  Pages: 998-1005
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] International Union of Pharmacology. LIV. Nomenclature and molecular relationships of Kir channels.2005
- Author(s)
  Kubo, Y.et al.(10 authors in total)
- Journal Title
  
  Pharmacological Reviews 57
  
  Pages: 509-526
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Protein Kinase C shifts the voltage-dependence of KCNQ/M channels expressed in Xenopus oocytes.2005
- Author(s)
  Nakajo, K., Kubo, Y.
- Journal Title
  
  Journal of Physiology 569
  
  Pages: 59-74
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Visualization of the trimeric P2X2 receptor with a crown-capped extracellular domain.2005
- Author(s)
  Mio, K., Kubo, Y., Ogura, T., Yamamoto, T., Sato, C.
- Journal Title
  
  Biochemical and Biophysical Research Communications 337
  
  Pages: 998-1005
- Data Source
  KAKENHI-PROJECT-17024058
[Journal Article] OPA1 expression in the normal rat retina and optic nerve.2005
- Author(s)
  Ju, W.K., Misaka, T., Kushnareva, Y., Nakagomi, S, Agarwal, N., Kubo, Y.et al.
- Journal Title
  
  Journal of Comparative Neurology 488
  
  Pages: 1-10
- Data Source
  KAKENHI-PROJECT-16047205
[Journal Article] Visualization of the trimeric P2X_2 receptor with a crown-capped extracellular domain.2005
- Author(s)
  Mio, K., Kubo, Y., Ogura, T., Yamamoto, T., Sato, C.
- Journal Title
  
  Biochemical and Biophysical Research Communications 337
  
  Pages: 998-1005
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Structure and functional regulation of the metabotropic glutamate receptor2005
- Author(s)
  Kubo, Y, Tateyama, M.
- Journal Title
  
  Clinical Neuroscience 24
  
  Pages: 149-152
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Towards a view of functioning dimeric metabotropic receptors2005
- Author(s)
  Kubo, Y., Tateyama, M.
- Journal Title
  
  Current Opinion in Neurobiology 57
  
  Pages: 509-526
- Data Source
  KAKENHI-PROJECT-17024058
[Journal Article] Towards a view of functioning dimeric metabotropic receptors2005
- Author(s)
  Kubo, Y., Tateyama, M.
- Journal Title
  
  Current Opinion in Neurobiology 15
  
  Pages: 289-295
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] 代謝型グルタミン酸受容体の構造と機能調節機構2005
- Author(s)
  久保義弘, 立山充博
- Journal Title
  
  Clinical Neuroscience 24
  
  Pages: 149-152
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Towards a view of functioning dimeric metabotropic receptors.2005
- Author(s)
  Kubo, Y., Tateyama, M.
- Journal Title
  
  Current Opinion in Neurobiology 15
  
  Pages: 289-295
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Protein Kinase C shifts the voltage-dependence of KCNQ/M channels expressed in Xenopus oocytes.2005
- Author(s)
  Nakajo, K., Kubo, Y.
- Journal Title
  
  Journal of Physiology 569
  
  Pages: 59-74
- Data Source
  KAKENHI-PROJECT-17024058
[Journal Article] International Union of Pharmacology. LIV. Nomenclature and molecular relationships of Kir channels.2005
- Author(s)
  Kubo, Y. 他9名.
- Journal Title
  
  Pharmacological Reviews 57
  
  Pages: 509-526
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Towards a view of functioning dimeric metabotropic receptors2005
- Author(s)
  Kubo, Y., Tateyama, M.
- Journal Title
  
  Current Opinion in Neurobiology 57
  
  Pages: 509-526
- Data Source
  KAKENHI-PROJECT-16047205
[Journal Article] Towards a view of functioning dimeric metabotropic receptors2005
- Author(s)
  Kubo, Y., Tateyama, M.
- Journal Title
  
  Current Opinion in Neurobiology 57
  
  Pages: 509-526
- Data Source
  KAKENHI-PROJECT-16659053
[Journal Article] Protein Kinase C shifts the voltage-dependence of KCNQ/M channels expressed in Xenopus oocytes.2005
- Author(s)
  Nakajo, K., Kubo, Y.
- Journal Title
  
  Journal of Physiology 569
  
  Pages: 59-74
- Data Source
  KAKENHI-PROJECT-16659053
[Journal Article] Protein Kinase C shifts the voltage-dependence of KCNQ/M channels expressed in Xenopus oocytes.2005
- Author(s)
  Nakajo, K., Kubo, Y.
- Journal Title
  
  Journal of Physiology 569
  
  Pages: 59-74
- Data Source
  KAKENHI-PROJECT-16047205
[Journal Article] OPA1 expression in the normal rat retina and optic nerve.2005
- Author(s)
  Ju, W.K., Misaka, T., Kushnareva, Y., Nakagomi, S, Agarwal, N., Kubo, Y.et al.
- Journal Title
  
  Journal of Comparative Neurology 488
  
  Pages: 1-10
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Visualization of the trimeric P2X2 receptor with a crown-capped extracellular domain.2005
- Author(s)
  Mio, K., Kubo, Y., Ogura, T., Yamamoto, T., Sato, C.
- Journal Title
  
  Biochemical and Biophysical Research Communications 337
  
  Pages: 998-1005
- Data Source
  KAKENHI-PROJECT-16659053
[Journal Article] 内向き整流性K^+ チャネルIRK1の構造機能連関とその遺伝子異常による疾患2005
- Author(s)
  久保義弘, 藤原祐一郎
- Journal Title
  
  別冊医学のあゆみ「イオンチャネル最前線 update」(倉智嘉久編) Suppl.215
  
  Pages: 88-93
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] OPA1 expression in the normal rat retina and optic nerve.2005
- Author(s)
  Ju, W.K., Misaka, T., Kushnareva, Y., Nakagomi, S., Agarwal, N., Kubo, Y., et al.
- Journal Title
  
  Journal of Comparative Neurology 488
  
  Pages: 1-10
- Data Source
  KAKENHI-PROJECT-17024058
[Journal Article] Density Dependent Changes of the Pore Properties of P2X_2 Receptor2004
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of Physiology 558
  
  Pages: 31-43
- Data Source
  KAKENHI-PROJECT-16015238
[Journal Article] Density Dependent Changes of the Pore Properties of P2X_2 Receptor2004
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of Physiology 558
  
  Pages: 31-43
- Data Source
  KAKENHI-PROJECT-15029214
[Journal Article] Ligand-induced rearrangement of the intracellular dimeric conformation of metabotropic glutamate receptorla.2004
- Author(s)
  Tateyama, M., Abe, H., Nakata, H., Saitoh, O, Kubo, Y.
- Journal Title
  
  Nature Structural & Molecular Biology 11
  
  Pages: 637-642
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Biochemical and Physiological analyses of the RGS8 function2004
- Author(s)
  Saitoh, O, Kubo, Y.
- Journal Title
  
  Methods in Enzymology 390
  
  Pages: 129-148
- Data Source
  KAKENHI-PROJECT-16015238
[Journal Article] Density Dependent Changes of the Pore Properties of P2X_2 Receptor2004
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of Physiology 558
  
  Pages: 31-43
- Data Source
  KAKENHI-PROJECT-16047205
[Journal Article] Density Dependent Changes of the Pore Properties of P2X_2 Receptor Channel.2004
- Author(s)
  Fujiwara, Y, Kubo, Y.
- Journal Title
  
  Journal of Physiology 558
  
  Pages: 31-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Density Dependent Changes of the Pore Properties of P2X_2 Receptor Channel.2004
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of Physiology 558
  
  Pages: 31-43
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Biochemical and Physiological Analyses of the RGS8 function2004
- Author(s)
  Saitoh, O, Kubo, Y.
- Journal Title
  
  Methods in Enzymology 390
  
  Pages: 129-148
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Ligand-induced rearrangement of the intracellular dimeric conformation of metabotropic glutamate receptor 1a.2004
- Author(s)
  Tateyama, M., Abe H., Nakata, H., Saitoh, O., Kubo, Y.
- Journal Title
  
  Nature Structural & Molecular Biology 11
  
  Pages: 637-642
- Data Source
  KAKENHI-PROJECT-16659053
[Journal Article] Biochemical and Physiological Analyses of the RGS8 function2004
- Author(s)
  Saitoh, O., Kubo, Y.
- Journal Title
  
  Methods in Enzymology 390
  
  Pages: 129-148
- Data Source
  KAKENHI-PROJECT-16659053
[Journal Article] Ligand-induced rearrangement of the intracellular dimeric conformation of metabotropic glutamate receptor1a.2004
- Author(s)
  Tateyama, M., Abe, H., Nakata, H., Saitoh, O, Kubo, Y.
- Journal Title
  
  Nature Structural & Molecular Biology 11
  
  Pages: 637-642
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Density dependent changes of the pore properties of P2X_2 receptor channel.2004
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  Journal of Physiology 558
  
  Pages: 31-43
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Ligand-induced rearrangement of the intracellular dimeric conformation of metabotropic glutamate receptor 1a.2004
- Author(s)
  Tateyama, M., Abe, H., Nakata, H., Saitoh, O., Kubo, Y.
- Journal Title
  
  Nature Structural & Molecular Biology 11
  
  Pages: 637-642
- Data Source
  KAKENHI-PROJECT-16015238
[Journal Article] Ligand-induced rearrangement of the intracellular dimeric conformation of metabotropic glutamate receptor 1a.2004
- Author(s)
  Tateyama, M., Abe, H., Nakata, H., Saitoh, O., Kubo, Y.
- Journal Title
  
  Nature Structural & Molecular Biology 11
  
  Pages: 637-642
- Data Source
  KAKENHI-PROJECT-16047205
[Journal Article] Biochemical and Physiological Analyses of the RGS8 function2004
- Author(s)
  Saitoh, O., Kubo, Y.
- Journal Title
  
  Methods in Enzymology 390
  
  Pages: 129-148
- Data Source
  KAKENHI-PROJECT-16047205
[Journal Article] Ligand-induced rearrangement of the intracellular dimeric conformation of metabotropic glutamate receptor1α.2004
- Author(s)
  Tateyama, M., Abe, H., Nakata, H., Saitoh, O, Kubo, Y.
- Journal Title
  
  Nature Structural & Molecular Biology 11
  
  Pages: 637-642
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390052
[Journal Article] Density Dependent Changes of the Pore Properties of P2X_2 Receptor2004
- Author(s)
  Fujiwara, Y., Kubo, Y.
- Journal Title
  
  journal of Physiology 558
  
  Pages: 31-43
- Data Source
  KAKENHI-PROJECT-16659053
[Journal Article] Ligand-induced rearrangement of the intracellular dimeric conformation of metabotropic glutamate receptor 1a.2004
- Author(s)
  Tateyama, M., Abe, H., Nakata, H., Saitoh, O., Kubo, Y.
- Journal Title
  
  Nature Structural & Molecular Biology 11
  
  Pages: 637-642
- Data Source
  KAKENHI-PROJECT-15029214
[Journal Article] Biochemical and Physiological Analyses of the RGS8 function2004
- Author(s)
  Saitoh, O., Kubo Y.
- Journal Title
  
  Methods in Enzymology 390
  
  Pages: 129-148
- Data Source
  KAKENHI-PROJECT-15029214
[Journal Article] The intra-molecular activation mechanisms of the dimeric metabotropic glutamate receptor 1 differ depending on the type of G proteins.
- Author(s)
  立山充博, 久保義弘
- Journal Title
  
  Neuropharmacol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] Structual determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist2024
- Author(s)
  Chang Liu, I-Shan Chen, Yoshihiro Kubo
- Organizer
  The 101th Annual Meeting of The Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-23K27358
[Presentation] A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel.2023
- Author(s)
  Yoshihiro Kubo
- Organizer
  The 10th Annual Meeting of the Mongolian Neuroscience Society (Ulaanbaatar, Mongolia)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27358
[Presentation] The transmembrane domains of THIK-1 channel play critical roles in the regulation of channel activity2023
- Author(s)
  Tateyama M, Kubo Y
- Organizer
  第100回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel.2023
- Author(s)
  Yoshihiro Kubo
- Organizer
  Center for Synthetic Biology TU Darmstadt International Symposium “Understanding and Building Ion Channels” (Darmstadt, Germany)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27358
[Presentation] A switching mechansim of PIP2- and voltage- gating modes depending on the conformatuions of the second S4 helix in two pore channels2023
- Author(s)
  Shimomura T, Hirazawa K, Kubo Y
- Organizer
  第100回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Structure-function relationship study of ion channels -- Looking back and seeing ahead.2023
- Author(s)
  Yoshihiro Kubo
- Organizer
  IBRO-APRC Associate School on Behavioral and Translational Neuroscience (Ulaanbaatar, Mongolia)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27358
[Presentation] Structural determinants of the inhibition of M2R by Sigma-1 receptor2023
- Author(s)
  Liu C, Murrell-Lagnado R, Kubo Y
- Organizer
  第100回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Analysis ofthe dynamic structure of voltage-gated cation channels using transition metal ion forster resonance energy transfer2023
- Author(s)
  Hirazawa K, Shimomura T, Kubo Y
- Organizer
  第100回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel.2023
- Author(s)
  Yoshihiro Kubo
- Organizer
  The 9th International Ion Channel Conference (Nanjing, China)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27358
[Presentation] The 4th transmembrane domain of THIK-1 channel plays critical roles in the regulation of the channel activity2022
- Author(s)
  Michihiro Tateyama, Yoshihiro Kubo
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Voltage-clamp fluorometry analysis of the hyperpolarized-induced structural rearrangements of ATP-gated channel P2X22022
- Author(s)
  Rizki Tsari Andriani, Yoshihiro Kubo
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Phosphoinositide-dependent modulation of the structural rearrangements of Two-pore channel 3 evoked by depolarization2022
- Author(s)
  Ki-ichi Hirazawa, Michihiro Tateyama, Takushi Shimomura, Yoshihiro Kubo
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Identification of mechanisms underlying the abnormal ion selectivity induced by gene mutations of GIRK2 channel2022
- Author(s)
  I-Shan Chen and Yoshihiro Kubo
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel2022
- Author(s)
  Kubo Y
- Organizer
  The 37th International Union of Physiological Sciences(IUPS) Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Regulation of muscarinic acetylcholine receptor M2 by Sigma-1 receptor2022
- Author(s)
  Chang Liu, I-Shan Chen, Ruth Murrell-Lagnado, Yoshihiro Kubo
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Analysis of the relationship between channel opening and position of the second S4 helix in two-pore Na+ channel 32022
- Author(s)
  Takushi Shimomura, Ki-ichi Hirazawa, Yoshihiro Kubo
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Novel mechanisms underlying the abnormal ion selectivity of inherent GIRK mutants2021
- Author(s)
  Chen I-Shan, Yoshihiro Kubo
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] The distal C-terminal region of the THIK channels plays critical roles in the regulation of the channel activity2021
- Author(s)
  Tateyama Michihiro, Yoshihiro Kubo
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Optical monitoring of voltage-dependent gating of ATP-gated channel P2X2 by utilizing fluorescent unnatural amino acid (fUAA)2021
- Author(s)
  Andriani Rizki Tsari, Yoshihiro Kubo
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Analysis of the activation mechanism of Two-pore channel 3 by membrane voltage and phosphoinositide2021
- Author(s)
  Hirazawa Ki-ichi, Takushi Shimomura, Yoshihiro Kubo
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Regulation of the function of Kv channels by Sigma-1 receptor2021
- Author(s)
  Liu Chang, I-Shan Chen, Ruth Murrell-Lagnado, Yoshihiro Kubo
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] Cysteine scanning analysis of the 2nd S4 in two-pore Na+ channel 32021
- Author(s)
  Shimomura Takushi, Ki-ichi Hirazawa, Yoshihiro Kubo
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20H03424
[Presentation] PI(3,4)P2-dependent modulation of voltage dependence in Two-Pore Chanel 32020
- Author(s)
  Shimomura T, Kubo Y
- Organizer
  Biophysical Society 64th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] PI(3,4)P2- and voltage-dependent gating of two-pore Na+ channel 32020
- Author(s)
  Shimomura T, Hirazawa K, Kubo Y
- Organizer
  The 97th Annual Meeting of the Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Analysis of the structural dynamics of Two-pore Na+ channel 32020
- Author(s)
  Hirazawa K, Shimomura T, Kubo Y
- Organizer
  The 97th Annual Meeting of the Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Activation of the THIK-2 channels by Gi/o and Gq coupled receptors2020
- Author(s)
  Tateyama M, Kubo Y
- Organizer
  The 97th Annual Meeting of the Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Inhibitory mechanisms of G-protein-gated inwardly rectifying K+ channel by antihistamines2020
- Author(s)
  Chen IS, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y
- Organizer
  Biophysical Society 64th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Physiological roles of Prrt3, an orphan metabotropic receptor: Comprehensive behavioral test battery analysis using homozgous full gene knock-out mice derived from flox mice2020
- Author(s)
  Yamamoto T, Hattori S, Zhou L, Natsume R, Konno K, Chen IS, Watanabe M, Sakimura K, Miyakawa T, Kubo Y
- Organizer
  The 97th Annual Meeting of the Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Modulation of ion channel function by Sigma-1 receptor, a multimodal membrane protein2020
- Author(s)
  Liu C, Chen IS, Murrell-Lagnado R, Kubo Y
- Organizer
  The 97th Annual Meeting of the Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Relative voltage sensor activation kinetics determines the effects of sensor neutralization in voltage-gated sodium channels2020
- Author(s)
  Brake, N, Manchino A, Yan Y, Shimomura T, Kubo Y, Bowie D, Khadra A
- Organizer
  Biophysical Society 64th Annual Meeting
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] ATP- and voltage-dependent gating of P2X2 receptor analyzed by voltage-clamp fluorometry2020
- Author(s)
  Andriani RT, Kubo Y
- Organizer
  The 97th Annual Meeting of the Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Analysis of dynamic structural rearrangements of Two-Pore Na+ Channel 3 by voltage clamp fluorometry2019
- Author(s)
  Hirazawa K, Shimomura T, Kubo Y
- Organizer
  9th FAOPS congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] ATP-and voltage-dependent gating of P2X2 receptor analyzed by voltage-clamp fluorometry2019
- Author(s)
  Andriani RT, Kubo Y
- Organizer
  The 7th International Ion Channel Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Phosphoinositides modulate the voltage dependence of Two-Pore Channel 32019
- Author(s)
  Kubo Y
- Organizer
  The 7th International Ion Channel Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Effects of antihistamine drugs on G-protein-gated inwardly rectifying K+ channels2019
- Author(s)
  Chang L, Chen IS, Kubo Y
- Organizer
  9th FAOPS congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Voltage-clamp fluorometry analyses of voltage-dependent gating of ATP receptor channel P2X22019
- Author(s)
  Rizki AT, Kubo Y
- Organizer
  9th FAOPS congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Regulation mechanisms of G-protein-gated inwardly rectifying K+channel by small molecules2019
- Author(s)
  Chen IS, Liu C, Kubo Y
- Organizer
  9th FAOPS congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Metabotropic glutamate receptor mGlu2 regulates signaling via Gq-coupled serotonergic receptor2019
- Author(s)
  Tateyama M, Kubo Y
- Organizer
  9th FAOPS congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] A key interaction for modulation of voltage dependence by phosphoinositides in two-pore channel 32019
- Author(s)
  Shimomura T, Kubo Y
- Organizer
  9th FAOPS congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Phosphoinositides modulate the voltage dependence in Two-Pore Na+ Channel 32019
- Author(s)
  Kubo Y
- Organizer
  The Ion Channel Modulation Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Modulation of the voltage dependence by phosphoinositides in Two-Pore Na+ Channel 32018
- Author(s)
  Shimomura T, Kubo Y
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Novel regulation mechanisms of the GIRK channel activity by small molecules2018
- Author(s)
  Chen IS, Kubo Y
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] FRET analyses of the effect of Phe860Glu mutation on the interaction between the N- and C- terminal cytoplasmic domains in hERG channel2018
- Author(s)
  Kume S, Tateyama M, Kubo Y
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Analyses of the structural rearrangements of P2X2 receptor by voltage-clamp fluorometry using fUAA fluorophore - quencher pairing2018
- Author(s)
  Andriani RT, Kubo Y
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Effects and activation mechanisms of ivermectin on G-protein-gated inwardly rectifying potassium channels.2018
- Author(s)
  Chen IS, Tateyama M, Fukata Y, Uesugi M, Kubo Y
- Organizer
  62nd Annual Meeting of Biophysical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Effects and activation mechanisms of antiparasitic agents on GIRK channels2017
- Author(s)
  Chen IS, Kubo Y
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  静岡県、浜松市、アクトシティ浜松
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-26293044
[Presentation] Activation mechanisms and binding sites of ivermectin in G-protein-gated inwardly rectifying potassium channels2017
- Author(s)
  Kubo Y
- Organizer
  IUPS 38th World Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021
[Presentation] Behavioral analyses of forebrain specific knock-out mice of an orphan metabotropic receptor Prrt3 and screening of small molecule library toward identification of its ligand2017
- Author(s)
  Chen IS, Yamamoto T, Zhou Li, Natsume R, Konno K, Uesugi M, Watanabe M, Takao K, Miyakawa T, Sakimura K, Kubo Y
- Organizer
  第40回日本神経科学大会
- Place of Presentation
  千葉県、幕張市、幕張メッセ
- Year and Date
  2017-07-20
- Data Source
  KAKENHI-PROJECT-26293044
[Presentation] Voltage-clamp fluorometry analyses of the secondary structural rearrangements of ATP-gated P2X2 receptor2017
- Author(s)
  Andriani RT, Kubo Y
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  静岡県、浜松市、アクトシティ浜松
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15K15036
[Presentation] Activation mechanisms of an orphan metabotropic receptor Prrt32016
- Author(s)
  陳以珊、山本友美、久保義弘
- Organizer
  第93回　日本生理学会
- Place of Presentation
  札幌コンベンションセンター（北海道、札幌市）
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-26293044
[Presentation] Analyses of structural rearrangements of P2X2 by voltage-clamp fluorometry using fluorescent unnatural amino acid2016
- Author(s)
  Andriani Rizki Tsari, Kubo Yoshihiro
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道、札幌市）
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K15036
[Presentation] Signal transmission within the P2X2 trimeric receptor and the voltage dependent structural rearrangements2015
- Author(s)
  Yoshihiro Kubo
- Organizer
  The 5th International Ion Channel Conference
- Place of Presentation
  Luzhou Convention Center (Luzhou, China)
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-15K15036
[Presentation] Exploring the original function of AMPA receptor2015
- Author(s)
  Shinobu Hirai, Koji Hotta, Yoshihiro Kubo, Yasushi Okamura, Haruo Okado
- Organizer
  第９２回日本生理学会（神戸）
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-03-21
- Data Source
  KAKENHI-PROJECT-221S0003
[Presentation] LC-MS/MS analysis of an orphan metabotropic receptor Prrt3 complex2015
- Author(s)
  山本泉、横井紀彦、深田優子、今野幸太郎、山本友美、渡辺雅彦、深田正紀、久保義弘
- Organizer
  第92回　日本生理学会大会
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-03-21
- Data Source
  KAKENHI-PROJECT-26293044
[Presentation] Stabilizing effects of G protein on the active conformation of the adenosine receptor type1a differ depending on the type of G protein2014
- Author(s)
  Tateyama M, Kubo Y
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス, 鹿児島県
- Year and Date
  2014-03-16
- Data Source
  KAKENHI-PROJECT-23390045
[Presentation] Comprehensive behavioral battery analyses of the gene targeted mice of prrt3, an orphan metabotropic receptor2014
- Author(s)
  Yamamoto T, Hattori S, Kiyonari H, Nakao K, Miyakawa T, Kubo Y
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス, 鹿児島県
- Year and Date
  2014-03-16
- Data Source
  KAKENHI-PROJECT-23390045
[Presentation] Stabilizing effects of G protein on the active conformation of the adenosine receptor type1a differ depending on the type of G protein2014
- Author(s)
  立山充博、久保義弘
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス、鹿児島県
- Data Source
  KAKENHI-PROJECT-23390045
[Presentation] An investigation of post-translational cleavage of an orphan metabotropic receptor, Prrt3.2014
- Author(s)
  山本泉、山本友美、今野幸太郎、渡辺雅彦、久保義弘
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシィフィコ横浜（神奈川県、横浜市）
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26293044
[Presentation] Expression patterns of an orphan meabotropic receptor Prrt3 in mice2014
- Author(s)
  山本泉、今野幸太郎、山本友美、渡辺雅彦、久保義弘
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス、鹿児島県
- Data Source
  KAKENHI-PROJECT-23390045
[Presentation] Comprehensive behavioral test battery analyses of the gene targeted mice of Prrt3, an orphan metabotropic receptor2014
- Author(s)
  山本友美、服部聡子、清成寛、中尾和貴、宮川剛、久保義弘
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス、鹿児島県
- Data Source
  KAKENHI-PROJECT-23390045
[Presentation] Expression patterns of an orphan metabotropic receptor Prrt3 in mice2014
- Author(s)
  Yamamoto I, Konno K, Yamamoto T, Watanabe M, Kubo Y
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス, 鹿児島県
- Year and Date
  2014-03-16
- Data Source
  KAKENHI-PROJECT-23390045
[Presentation] 哺乳類two-pore型カリウムチャネルTWIK-1の全反射赤外分光解析2013
- Author(s)
  塚本寿夫、中條浩一、久保義弘、古谷祐詞
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-24650203
[Presentation] Binding of the Gq protein stabilizes the active conformation of the M1R and M3R, but not of P2Y1R2013
- Author(s)
  Tateyama M, Kubo Y
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  タワーホール船堀, 東京都
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23390045
[Presentation] 哺乳動物カリウムチャネルの赤外分光解析2013
- Author(s)
  塚本寿夫、中條浩一、久保義弘、古谷祐詞
- Organizer
  平成24年度生物物理学会中部支部講演会
- Place of Presentation
  名古屋(名古屋大学)(口頭)
- Year and Date
  2013-02-19
- Data Source
  KAKENHI-PROJECT-24650203
[Presentation] Subunit stoichiometry and signal flow analyses in the P2X2 trimer upon voltageand [ATP]-dependent activation2013
- Author(s)
  Batu Keceli, Yoshihiro Kubo
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  タワーホール船堀、東京都
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] Overview of the structure-function relationship and the regulation mechanisms of ATP receptor channel P2X2013
- Author(s)
  Yoshihiro Kubo, Batu Keceli
- Organizer
  第86回日本薬理学会年会, シンポジウム「Updating physiological understanding of P2X receptor functions for novel pharmacology」
- Place of Presentation
  福岡国際会議場、福岡県
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] 哺乳類two-pore型カリウムチャネルTWIK-1の全反射赤外分光解析2013
- Author(s)
  塚本寿夫、中條浩一、久保義弘、古谷祐詞
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  京都(京都国際会議場)
- Data Source
  KAKENHI-PROJECT-24650203
[Presentation] Analyses of the signal flow and subunits' contribution in the P2X2 trimer upon voltage and [ATP]-dependent activation by three tandem repeat constructs Purine 2012 International Meeting2012
- Author(s)
  Yoshihiro Kubo
- Organizer
  Structure and dynamic properties of P2X receptors
- Place of Presentation
  九州大学医学部百年講堂、福岡県
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] 生物物理学的解析を目指した、哺乳培養細胞を用いた哺乳類カリウムイオンチャネルの大量発現の試み2012
- Author(s)
  塚本寿夫、中條浩一、久保義弘、古谷祐詞
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋(名古屋大学)(ポスター)
- Data Source
  KAKENHI-PROJECT-24650203
[Presentation] Epigenetic regulation of mouse neural stem cell differentiation and functional brain development.2012
- Author(s)
  Taga T, Kagawa T, Bizen N, Yamaguchi Y, Kokubo Y, Hattori S, Takao K, Miyakawa T, Inazawa J, Nakamura T, Nakano T.
- Organizer
  International society for stem cell research 10th annual meeting
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-221S0003
[Presentation] FRETによる受容体活性化過程の可視化2012
- Author(s)
  立山充博、久保義弘
- Organizer
  第132回日本薬学会(招待講演)
- Place of Presentation
  北海道大学・高等教育推進機構（北海道）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] Analyses of the signal flow and subunits’ contribution in the P2X2 trimer upon voltage- and [ATP]- dependent activation by three tandem repeat constructs.2012
- Author(s)
  Batu Keceli, Yoshihiro Kubo
- Organizer
  Gordon Research Conference -Ligand Recognition and Molecular Gating-
- Place of Presentation
  Four Points Sheraton (Ventura, CA, USA)
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] Structural rearrangements of the linker region between the ATP binding site and the transmembrane domains upon P2X2 receptor channel gating2012
- Author(s)
  Batu Keceli, Yoshihiro Kubo
- Organizer
  Purine 2012 International Meeting
- Place of Presentation
  九州大学医学部百年講堂、福岡県
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] Analyses of the signal flow and subunits' contribution in the P2X2 trimer upon voltage- and [ATP]-dependent activation by three tandem repeat constructs2012
- Author(s)
  Batu Keceli, Yoshihiro Kubo
- Organizer
  Gordon Research Conference -Ligand Recognition and Molecular Gating-
- Place of Presentation
  Four Points Sheraton (Ventura, CA, USA)
- Year and Date
  2012-01-16
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] Effects of the Gq coupling on the activated states of the receptor differ depending on the type of the receptors2012
- Author(s)
  Tateyama M, Kubo Y
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋国際会議場, 愛知県
- Year and Date
  2012-09-18
- Data Source
  KAKENHI-PROJECT-23390045
[Presentation] 生物物理学的解析を目指した、哺乳培養細胞を用いた哺乳類カリウムイオンチャネルの大量発現の試み2012
- Author(s)
  塚本寿夫、中條浩一、久保義弘、古谷祐詞
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学（愛知県)
- Data Source
  KAKENHI-PROJECT-24650203
[Presentation] FRET analysis of G protein coupled receptors2012
- Author(s)
  立山充博, 松下真一, 久保義弘
- Organizer
  シンポジウム「イメージングより明らかにされたGタンパク質共役型受容体のダイナミクス」第134回日本薬学会年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] Structural rearrangements of the b-sheets linking the ATP binding site to the trans membrane domains upon P2X2 receptor channel gating2012
- Author(s)
  Batu Keceli, Yoshihiro Kubo
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本文化会館（長野県）
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] Structural rearrangements of the b-sheets linking the ATP binding site to the trans membrane domains upon P2X2 receptor channel gating2012
- Author(s)
  Batu Keceli, Yoshihiro Kubo
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本文化会館(長野県)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] ホモ2量体代謝型グルタミン酸受容体1型の分子内活性化機構は、結合するGタンパク質の種類によって異なる2011
- Author(s)
  立山充博、久保義弘
- Organizer
  第84回日本生化学会大会(招待講演)
- Place of Presentation
  国立京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] Analyses of the signal flow and subunits' contribution in the P2X2 trimer upon voltage- and [ATP]-dependent activation by three tandem repeat constructs2011
- Author(s)
  Batu Keceli, Yoshihiro Kubo
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] pH感受性内向き整流カリウムチャネルKir2.3の心臓における役割2011
- Author(s)
  石原圭子、村田祐造、山本友美、市島久仁彦、福留健司、塩谷孝夫、増子貞彦、久保義弘
- Organizer
  第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会合同大会
- Place of Presentation
  Journal of Physiological Sciences(誌上開催)
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] Ligand-induced structural rearrangements of G protein coupled receptors revealed by FRET analysis2011
- Author(s)
  立山充博、松下真一、久保義弘
- Organizer
  第87回日本薬理学会大会
- Place of Presentation
  パシフィコ横浜(神奈川県)(大会は中止、紙面発表)
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] Analyses of the signal flow and subunits’ contribution in the P2X2 trimer upon voltage- and [ATP]-dependent activation by three tandem repeat constructs.2011
- Author(s)
  Batu Keceli, Yoshihiro Kubo
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] Ligand-induced structural rearrangements of G protein coupled receptors revealed by FRET analysis2011
- Author(s)
  立山充博、松下真一、久保義弘
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] Role of the pH-sensitive strong inward rectifier Kir2.3 in the heart2011
- Author(s)
  Ishihara K, Murata Y, Yamamoto T, Ichishima K, Fukudome K, Shioya T, Masuko S, Kubo Y
- Organizer
  The 88th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Yokohama
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] m1ムスカリン受容体とGqタンパク質会合のFRET解析2011
- Author(s)
  立山充博、久保義弘
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] The intra-molecular activation mechanisms of the dimeric metabo- tropic glutamate receptor1 differ depending on the type of the coupled G-protein2011
- Author(s)
  立山充博, 久保義弘
- Organizer
  シンポジウム「GPCRシグナル伝達の構造と機能:創薬への新たな展開」第84回日本生化学大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] FRET analysis revealed difference in the Gq coupling between m1 muscarinic receptor and metabotropic glutamate receptor12010
- Author(s)
  立山充博、久保義弘
- Organizer
  第33回日本神経科学会大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] Kir2とKir3サブファミリーに属する内向き整流K^+チャネル・サブユニットは異種発現系においてヘテロ多量体を形成する2010
- Author(s)
  石原圭子、山本友美、久保義弘
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  岩手県盛岡市
- Data Source
  KAKENHI-PROJECT-22590208
[Presentation] Structural rearrangements of the motor protein prestin revealed by fluorescence resonance energy transfer2010
- Author(s)
  Gleitsman KR, Tateyama M, Kubo Y
- Organizer
  Biophysical Society Meeting
- Place of Presentation
  The Moscone center(San Francisco市, 米国)
- Year and Date
  2010-02-24
- Data Source
  KAKENHI-PROJECT-20056031
[Presentation] Inter-subunit interaction regulates the multiple signaling of metabotropic glutamate receptor 1a2010
- Author(s)
  立山充博、久保義弘
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡市民文化ホール(岩手)
- Year and Date
  2010-05-11
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] 代謝型グルタミン酸受容体の多様なシグナリングの調節機構2009
- Author(s)
  立山充博、久保義弘
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] Inetersubunit activation of metabotropic glutamate receptor 1a triggers Gq coupled signaling pathway, but not Gi/o one2009
- Author(s)
  立山充博、久保義弘
- Organizer
  第36回国際生理学会大会
- Place of Presentation
  京都国際会議場(京都府)
- Year and Date
  2009-07-31
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] 代謝型グルタミン酸受容体の多様なシグナリングの調節機構シンポジウム「グルタミン酸受容体の新側面」2009
- Author(s)
  立山充博、久保義弘
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] オーファン代謝型受容体Prrt3のマウス脳における発現の免疫組織化学的解析2009
- Author(s)
  山本友美、久保義弘
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-20390062
[Presentation] オーファン代謝型受容体 Prrt3のマウス脳における発現の免疫組織化学的解析2009
- Author(s)
  山本友美、久保義弘
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-20390062
[Presentation] Mutation analyses of the critical regions for the voltage and [ATP] dependent "gating" of P2X_2 receptor channel2009
- Author(s)
  Keceli B, Fujiwara Y, Kubo Y.
- Organizer
  Biophysical Society 53rd annual meeting
- Place of Presentation
  ボストン、米国
- Year and Date
  2009-03-02
- Data Source
  KAKENHI-PROJECT-19659053
[Presentation] Identification of the molecular determinant for the specis specific difference of the responses to caffeine between mouse and human TRPA12009
- Author(s)
  Nagatomo K, Kubo Y
- Organizer
  The 36th Congress of the International Union of Physiological Sciences
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-21659053
[Presentation] 代謝型グルタミン酸受容体2量体間の Trans 型活性化はGq応答を起こすがGi/o応答は起こさない2009
- Author(s)
  立山充博, 久保義弘
- Organizer
  日本薬理学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] Analysis of voltage and [ATP] dependent gating of P2X2 receptor channel by mutagenesis of the ATP binding region.2008
- Author(s)
  Batu Keceli, Yuichiro Fujiwara, Yoshihiro Kubo
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2008-03-25
- Data Source
  KAKENHI-PROJECT-18022042
[Presentation] TRPA1チャネルはカフェインにより活性化される2008
- Author(s)
  長友克広, 久保義弘
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2008-03-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390067
[Presentation] Activation of TRPA1 channel by caffeine2008
- Author(s)
  Nagatomo K and Kubo Y
- Organizer
  85th annual meeting of the Physiological Society of Japan
- Place of Presentation
  Tokyo
- Year and Date
  2008-03-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390067
[Presentation] Analysis of voltage and[ATP]dependent gating of P2X2 receptor channel by mutagenesis of the ATP binding region2008
- Author(s)
  Batu Keceli, Yuichiro Fujiwara, Yoshihiro Kubo
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2008-03-25
- Data Source
  KAKENHI-PROJECT-19659053
[Presentation] 内耳外有毛細胞の膜電位-細胞長変換素子プレスチンの単粒子構造解析2008
- Author(s)
  久保義弘、三尾和弘、小椋利彦、山本友美、佐藤主税
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20056031
[Presentation] PKA依存性リン酸化による代謝型グルタミン酸受容体I型の機能修飾2008
- Author(s)
  立山充博, 久保義弘
- Organizer
  日本神経科学学会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] Voltage and[ATP]dependent gating of the ATP receptor channel P2X22008
- Author(s)
  Yuichiro Fujiwara, Batu Keceli, Yoshihiro Kubo
- Organizer
  Biophysical Society 52nd Annual meeting
- Place of Presentation
  Long Beach,California,USA
- Year and Date
  2008-02-04
- Data Source
  KAKENHI-PROJECT-19659053
[Presentation] Voltage and [ATP] dependent gating of the ATP receptor channel P2X2.2008
- Author(s)
  Yuichiro Fujiwara, Batu Keceli, Yoshihiro Kubo
- Organizer
  Biophysical Society 52nd Annual meeting
- Place of Presentation
  Long Beach, California, USA
- Year and Date
  2008-02-04
- Data Source
  KAKENHI-PROJECT-18022042
[Presentation] TRPA1チャネルはカフェインにより活性化される2008
- Author(s)
  長友克広、久保義弘
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2008-03-25
- Data Source
  KAKENHI-PROJECT-18390067
[Presentation] Structural rearrangements of the linker region between the ATP binding site and the transmembrane domains upon P2X2 receptor channel gating.
- Author(s)
  Batu Keceli, Yoshihiro Kubo
- Organizer
  Purine 2012　International Meeting,
- Place of Presentation
  九州大学医学部百年講堂、福岡県
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] 受容体活性化状態に対するGqタンパク質の作用は受容体ごとに
- Author(s)
  立山充博、久保義弘
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] Binding of the Gq protein stabilizes the active conformation of the M1R and M3R, but not of P2Y1R.
- Author(s)
  立山充博、久保義弘
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  タワーホール船堀、東京都
- Data Source
  KAKENHI-PROJECT-23390045
[Presentation] 哺乳動物カリウムチャネルの赤外分光解析
- Author(s)
  塚本寿夫、中條浩一、久保義弘、古谷祐詞
- Organizer
  平成24年度　生物物理学会中部支部　講演会
- Place of Presentation
  名古屋大学（愛知県)
- Data Source
  KAKENHI-PROJECT-24650203
[Presentation] Subunit stoichiometry and signal flow analyses in the P2X2 trimer upon voltage- and [ATP]- dependent activation
- Author(s)
  Batu Keceli, Yoshihiro Kubo
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  タワーホール船堀、東京都
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] Effects of the Gq coupling on the activated states of the receptor differ depending on the type of
- Author(s)
  立山充博、久保義弘
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋国際会議場、愛知県
- Data Source
  KAKENHI-PROJECT-23390045
[Presentation] FRET analyses of the stabilizing effect of Gi1 protein on the agonist-induced activated conformation of the A1aR
- Author(s)
  立山充博、久保義弘
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  国際会議場（京都府）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] Overview of the structure-function relationship and the regulation mechanisms of ATP receptor channel P2X.
- Author(s)
  Yoshihiro Kubo, Batu Keceli
- Organizer
  第86回　日本薬理学会年会, シンポジウム「Updating physiological understanding of P2X receptor functions for novel pharmacology」
- Place of Presentation
  福岡国際会議場、福岡県
- Invited
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] Stabilizing effects of G protein on the active conformation of the adenosine receptor type 1a differ depending on the type of G protein
- Author(s)
  立山充博、久保義弘
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島県）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] Analyses of the signal flow and subunits’ contribution in the P2X2 trimer upon voltage and [ATP]- dependent activation by three tandem repeat constructs
- Author(s)
  Yoshihiro Kubo
- Organizer
  Purine 2012　International Meeting, Symposium “Structure and dynamic properties of P2X receptors”
- Place of Presentation
  九州大学医学部百年講堂、福岡県
- Invited
- Data Source
  KAKENHI-PROJECT-23659117
[Presentation] Gqタンパク質はM1RおよびM3Rの活性型構造に対し安定化作用を示すがP2Y1Rでは安定化作用を示さない
- Author(s)
  立山充博、久保義弘
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-23590270

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133. Kinoshita Makoto (30273460)

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134. Sugihara Izumi (60187656)

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135. Shirane Michiko (90398082)

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136. Yamamoto Nobuhiko (00191429)

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137. Nishijo Hisao (00189284)

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138. Nambu Atsushi (80180553)

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139. Takumi Toru (00222092)

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140. Yamashita Toshihide (10301269)

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141. Sakurai Takeshi (60251055)

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142. Tamamaki Nobuaki (20155253)

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143. Hata Yoshio (40212146)

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144. Harada Akihiro (40251441)

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145. Ozaki Norio (40281480)

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146. Sakai Katsuyuki (70376416)

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147. Nakazawa Takanobu (00447335)

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148. Tanaka Kenji (30329700)

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149. Takei Nobuyuki (70221372)

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150. Hitoshi Seiji (70300895)

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151. Takahiroa. Kato (70546465)

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152. Kato Fusao (20169519)

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153. Shirao Tomoaki (20171043)

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154. Taira Masato (50179397)

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155. Okano Hideyuki (60160694)

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156. Sekino Yuko (70138866)

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157. Okamoto Yasumasa (70314763)

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158. KOMATSU Hidehiko (00153669)

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159. Miyata Takaki (70311751)

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160. Takahashi Yoshiko (10183857)

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161. Nishida Shinya (20396162)

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162. Tominaga Makoto (90260041)

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163. 小田桐恵 (10260308)

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164. KECELI Batu (80645250)

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165. 東田陽博 (30093066)

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166. 桐野豊 (10012668)

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167. 寺田一志 (90227520)

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168. 西藤泰昌

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169. 平林真澄

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170. 三宝誠

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171. 崎村建司

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172. Tsari Andriani Rizki

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173. 下村拓史

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174. 井原邦夫

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175. 東雅大

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176. 青山幸平

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177. 齋藤実

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178. 川久保友紀

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Kubo Yoshihiro 久保 義弘

KUBO Yoshihiro 久保 義弘

Research Projects

Research Products

Co-Researchers

チャネルにおけるイオン透過と非典型的膜電位依存性ゲーティングのカップリングの検証Principal Investigator

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tmFRET analysis of the dynamic structural rearrangements of ion channelsPrincipal Investigator

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Analysis of dynamic structural rearrangements of functioning ion channels by fluorescent unnatural amino acidPrincipal Investigator

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Analyses of structural rearrangements of membrane proteins by fluorescent unnatural amino acid scanningPrincipal Investigator

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Analyses of an orphan metabotropic receptor which plays a role in the long term retention of memory, and a secretory protein encoded by its splice variantPrincipal Investigator

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Functional expression of mammalian ion channels and analysis of the molecular mechanisms

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Analyses of the function of Prrt3, an orphan family C metabotropic recptorPrincipal Investigator

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High time resolution FRET analysis of the activation of G protein

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Analyses of the signal flow upon activation of ATP receptor channel by tandem repeat constructsPrincipal Investigator

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Molecular mechanisms of the physiologically relevant component of the inward rectifier potassium channels that shows low sensitivity to the channel blockers

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Comprehensive Brain Science Network

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TRPA1チャネルのカフェインに対する応答の質的種間差異に基づく活性化機構の解明Principal Investigator

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膜電位-細胞長変換素子プレスチンの分子構築と動的構造変化の解析Principal Investigator

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Kubo Yoshihiro 久保義弘

KUBO Yoshihiro 久保義弘