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Harashima Hideyoshi  原島 秀吉

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… Alternative Names

HARASHIMA HIDEYOSHI  原島 秀吉

HARASHIMA Hideyoshi  原島 秀吉

原島 秀吉

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Researcher Number 00183567
Other IDs
Affiliation (Current) 2025: 北海道大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help 2019 – 2024: 北海道大学, 薬学研究院, 教授
2022: 北海道大学, 薬学研究院, 卓越教授
2009 – 2014: 北海道大学, 薬学研究科(研究院), 教授
2013: 北海道大学, 薬学研究院, 教授
2006 – 2012: 北海道大学, 大学院・薬学研究院, 教授 … More
2011: 北海道大学, 薬学研究科・研究院, 教授
2009 – 2011: 北海道大学, 薬学研究院, 教授
2010: 北海道大学
2010: 北海道大学, 大学院・農学研究院, 教授
2006: 北海道大学, 大学院薬学研究院, 教授
1999 – 2005: 北海道大学, 大学院・薬学研究科, 教授
2000: Hokkaido Univ., Faculty of Pharmaceutical Sciences, Prof., 薬学研究科, 教授
1997 – 1998: 徳島大学, 薬学部, 助教授
1990 – 1995: 徳島大学, 薬学部, 助教授
1987: 東京大学, 薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / 応用薬理学・医療系薬学 / Biomedical engineering/Biological material science / Physical pharmacy / Medical pharmacy / Physical pharmacy / Science and Engineering / Broad Section D / Basic Section 90120:Biomaterials-related / Medium-sized Section 90:Biomedical engineering and related fields / Biological pharmacy / Drug development chemistry … More
Except Principal Investigator
… More Physical pharmacy / Infectious disease medicine / Drug development chemistry / Medium-sized Section 90:Biomedical engineering and related fields / 応用薬理学・医療系薬学 Less
Keywords
Principal Investigator
GALA / MEND / 細胞内動態制御 / エンドサイトーシス / トランスフェリン / 遺伝子治療 / siRNA / 薬物送達システム / ミトコンドリア / がん … More / オクタアルギニン / エンドソーム / リポソーム / 細胞内動態 / endocytosis / 非ウイルスベクター / 遺伝子デリバリー / 網羅的解析 / 遺伝子診断 / 2型糖尿病 / 遺伝子ベクター / DDS / mRNA / 脂質ナノ粒子 / LNP / 核酸医薬 / ナノ医療 / 定量的評価 / アデノウイルス / intracellular trafficking / Liposomes / Drug delivery system / ウイルスベクター / 人工遺伝子デリバリーシステム / KALA / 核内動態制御 / アジュバント / 抗腫瘍効果 / ワクチン / ハイドロダイナミクス法 / 多機能性エンベロープ型ナノ構造体 / 多重型 / OLETFラット / パッケージング / 核局在化シグナル / ソーティング / レセプター / 耐性 / 分子シンクロナイゼーション / ターゲティング / 核移行シグナル / 腫瘍血管 / スマートポリマー / Microfluidic Device / Lipid Nanoparticles / Hepatic Stellate Cells / Liver fibrosis / liver fibrosis / hepatic stellate cells / ナノDDS / 核酸送達 / 細胞内局在 / ミトコンドリア遺伝子治療 / がん免疫療法 / ナノDDS / 核酸ナノ医療 / ナノ医薬品 / ゲノム編集 / がん免疫 / 律速段階 / programmed packaging / octaarginin / gene delivery system / ソーティング素子 / quantification / transcriptional efficiency / adeno-virus / 体内動態制御 / ライソゾーム / 共焦点レーザー顕微鏡 / 転写効率 / recycling / transferrin liposomes / リサイクル / トランスフェリン修飾リポソーム / Gene / Tumor / アンチセンス / 抗がん剤 / エネルギー代謝 / 遺伝子 / Diameter / Saturation / Complement receptor / Opsonin / Pharmacokinetics / 粒子径 / 飽和性 / 補体レセプター / オプソニン / 薬物速度論 / 細胞内シグナル / スイツチ / スイッチ / 樹状細胞 / DNAワクチン / スイッチ機能 / 機能性核酸 / 核送達 / バイセル / 自己活性化システム / ミトコンドリア送達 / 還元環境応答性 / pH-感受性カチオニック脂質 / ナノパッケージング / マイクロ流路 / ナノマシン / 抗原提示 / MHCクラス-I / 細胞透過性ペプチド / 細胞性免疫 / ナノ構造体 / トポロジー / エンドソーム脱出 / PPD / デリバリーシステム / R8-NEND / カベオラ / IRO / 遺伝子デリバリーシステム / 血管透過 / トランスサイトーシス / PPD-MEND / がん治療 / MMP / 遺伝子導入 / 細胞内ターゲティング / オルガネラターゲティング / MTS / 癌 / in vivo / 人工遺伝子デリバリー / 遺伝子発現 / カルパイン10 / Othuka Long-Evans Tokushima Fatty (OLETF)ラット / 遺伝子カテゴリー / 原子間顕微鏡 / ステアリルオクタアルギニン / 遺伝子デソバソー / 核膜 / 核膜融合モデル / ポリエチレンイミン / シンクロナイゼーション / 動写阻害 / リポリーム / エンドサイドシス / 転写阻害 / PCR / リソリーム … More
Except Principal Investigator
Glial-Derived Neurotrophic Factor / 結核 / 脂質 / 核酸医薬 / リポソーム / 薬物送達システム / 高分子ナノ粒子 / 脂質ナノ粒子 / 開環交互共重合 / 精密重合 / ドラッグデリバリーシステム / Glucose metabolism / Brain / Isolated perfused heart / Na^+,K^+ ATPase / Positive inotropic action / Ouabain / Cardiac glycosides / Na^+,Ka^+ATPase / ベンゾジアゼピン / K^+ATPase / Na^+ / ベンゾジアゼピンレセプター / グルコース代謝 / 脳 / 心臓灌流実験 / Na^+,K^+ATPase / 心筋収縮力 / ウアバイン / 強心配糖体 / Blood-brain barrier / Brain capillary endothelial cells / Parkinson' disease / HVJ-liposomes / Gene Therapy / 遺伝子の発現 / in vivo / in vitro / 血液脳関門 / 脳毛細血管内皮細胞 / パーキンソン病 / 膜融合リポソーム / 遺伝子治療 / Pharmacokinetics / Complement receptor / Opsonin / Lysosome / Macrophage / Liposome / Drug delivery system / 補体 / クリアランス / DDS / 細胞内運命 / リポソ-ム / 薬物速度論 / 補体レセプター / オプソニン / ライソゾーム / マクロファージ / ワクチン / 糖脂質 / 免疫学 / 感染症 / 細菌 / 機能性人工核酸 / ミトコンドリア / 2型糖尿病 / 疾患モデルマウス / 2型糖尿病 / ナノメディスン / 薬物送達 / マクロビノサイトーシス / 2'-0-メチル-4'-チオリポヌクレオシド / マクロピノサイトーシス / 膜透過性ペプチド / RNAi / アプタマー / 2'-0-メチル-4'-チオリボヌクレオシド / antisense RNA / si RNA / NMR / ヌクレアーゼ祇抗性核酸 / RNA干渉 / ゲノム創薬 / Dicer / ホタルルシフェラーゼ / 4'-チオDNA / 2'-O-メチル-4'-チオリボヌクレオシド / Apo-B / コレステロール / miRNA / MEND / SNALP / 2'-O-メチル-4'-チオリポヌクレオシド / ヌクレアーゼ抵抗性核酸 / ベクター / siRNA / 4'-チオ核酸 / ヌクレアーゼ抵抗性 Less
  • Research Projects

    (38 results)
  • Research Products

    (286 results)
  • Co-Researchers

    (53 People)
  •  Activated mRNA delivery system based on core-shell structured LNP with smart polymersPrincipal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2023 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section D
    • Research Institution
      Hokkaido University
  •  Strategic creation of polymer-lipid hybrid nanoparticles for tissue-selective nucleic acid delivery

    • Principal Investigator
      Isono Takuya
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Hokkaido University
  •  Development of gene delivery systems for liver diseases treatment and cancer treatmentPrincipal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Review Section
      Basic Section 90120:Biomaterials-related
    • Research Institution
      Hokkaido University
  •  Innovative gene/nucleic acid delivery system based on optimized intracellular trafficking stepsPrincipal Investigator

    • Principal Investigator
      HARASHIMA HIDEYOSHI
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Hokkaido University
  •  BCG搭載ナノ粒子の細胞内動態制御に基づいた革新的膀胱癌治療システムの創製Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Physical pharmacy
    • Research Institution
      Hokkaido University
  •  Development of a new type of anti-tuberculosis vaccines by the use of lipid immunity

    • Principal Investigator
      SUGITA Masahiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Infectious disease medicine
    • Research Institution
      Kyoto University
  •  MENDで拓く遺伝子治療への道:遺伝子の運び屋からナノマシンへPrincipal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Drug development chemistry
    • Research Institution
      Hokkaido University
  •  Programmed Activationに基づく人工DNAワクチンの創製Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Hokkaido University
  •  Novel gene delivery system with switch functionPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Physical pharmacy
    • Research Institution
      Hokkaido University
  •  Study on the innovative molecular-targeting medicine based on the nano-DDS encapsulating intelligent artificial oligonucleotides

    • Principal Investigator
      SASAKI Shigeki
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyushu University
  •  Developent of glycolipid vaccines against tuberculos is

    • Principal Investigator
      SUGITA Masahiko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Infectious disease medicine
    • Research Institution
      Kyoto University
  •  Multifunctional Envelope-type Nano Device as non-viral gene delivery system for cancer therapyPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  抗原提示バランスとアジュバントの制御に基づいたオーダーメイド癌ワクチンPrincipal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Hokkaido University
  •  がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Development of multifunctional envelope-type nano device encapsulating highly nuclease resistant oligonucleotides

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      2006 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Drug development chemistry
    • Research Institution
      Hokkaido University
  •  Development of in vivo gene delivery system for siRNA and genome wide screening of type-two diabetes related genes in mice and ratsPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Hokkaido University
  •  がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  ミトコンドリアを標的とする多重型・多機能性エンベロープ型ナノ構造体の開発Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Hokkaido University
  •  2型糖尿病の遺伝子診断用候補遺伝子の網羅的解析及びその機能解析Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  臨床試験導入を目指した肝がん用in vivo高発現型人工遺伝子ベクターの開発Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Development of Multifunctional Envelope type Nano Device based on Programmed PackagingPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  ゲノム機能情報に基づいた糖尿病薬の処方設計支援システムの構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Hokkaido University
  •  選択的抗癌システムを目指した細胞内動態の分子シンクロナイゼーションPrincipal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Hokkaido University
  •  遺伝子ベクター開発のための細胞内ソーティング素子のスクリーニング系の構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Optimization of pharmacokinetics and intracellular pharmacokinetics of viral and non-viral gene delivery systemPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Hokkaido University
  •  遺伝子ベクター開発のための細胞内ソーティング素子のスクリーニング素の構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  核ターゲティングの新戦略:核膜の特殊性に基づいた標的化Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Physical pharmacy
    • Research Institution
      Hokkaido University
  •  Intracellular control of transferrin-modified liposomes with Cholesteryl GALA for optimum drug delivery systemPrincipal Investigator

    • Principal Investigator
      HIDEYOSHI Harashima
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Hokkaido University
  •  選択的抗腫瘍システムの開発を目指した細胞内動態の分子シンクロナイゼーションPrincipal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Science and Engineering
    • Research Institution
      Hokkaido University
  •  Introduction of tyrosine hydroxylase gene into the cells from brain for the treatment of parkinson's disease.

    • Principal Investigator
      KOYABU Noriko, 松尾 浩民
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KYUSHU UNIVERSITY
  •  トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokushima
  •  核内転写制御による抗腫瘍効果を最適化するための細胞内動態制御システムの開発Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Hokkaido University
      The University of Tokushima
  •  Optimization of drug delivery system for antitumor agents based on the energy metabolism inhibition of tumor cellsPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokushima, Faculty of Pharmaceutical Sciences
  •  Uptake mechanism and intracellular destiny of liposomes in RESPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      The University of Tokushima, Faculty of Pharmaceutical Sciences
  •  Development of intracellular drug delivery system utilizing liposomes

    • Principal Investigator
      KIWADA Hiroshi
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      University of Tokushima
  •  Kinetical analysis of pharmacodynamics based on drug-receptor interactions

    • Principal Investigator
      HANANO Manabu
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      University of Tokyo

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All Journal Article Presentation Book Patent

  • [Book] 新規モダリティ医薬品のための新しいDDS技術と製剤化2023

    • Author(s)
      中村孝司、原島秀吉
    • Total Pages
      580
    • Publisher
      技術情報協会
    • ISBN
      9784861049361
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Book] THE創薬 小資源国家にっぽんの生きる道 日本薬学会編2021

    • Author(s)
      原島秀吉(共著)
    • Total Pages
      381
    • Publisher
      薬事日報社
    • ISBN
      9784840815536
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Book] ミトコンドリアダイナミクス. 第2編、第1章、第5節2021

    • Author(s)
      山田勇磨、原島秀吉
    • Total Pages
      381
    • Publisher
      株式会社エヌ・ティー・エス
    • ISBN
      9784860437466
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Book] 核酸科学ハンドブック2020

    • Author(s)
      原島秀吉(共著)
    • Total Pages
      565
    • Publisher
      講談社
    • ISBN
      9784065207864
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Book] ドラッグキャリア設計入門 DDSからナノマシンまで2019

    • Author(s)
      原島秀吉、片岡一則
    • Total Pages
      217
    • Publisher
      丸善出版株式会社
    • ISBN
      9784621303658
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Book] Application of a fusiogenic peptide GALA for intracellular delivery2011

    • Author(s)
      Nakase I, Kogure K, Harashima H, Futaki S
    • Total Pages
      10
    • Publisher
      Methods Mol Biol
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Book] Delivery of Nucleic Acids and Gene Delivery2011

    • Author(s)
      H.Akita, H.Hatakeyama, I.A.Khalil, Y.Yamada, H.Harashima
    • Total Pages
      34
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Book] ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用-遺伝子医学MOOK別冊2011

    • Author(s)
      山田勇磨、中村孝司、原島秀吉
    • Total Pages
      8
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Book] バイオテクノロジーシリーズ蛍光イメージング/MRIプローブの開発2011

    • Author(s)
      秋田英万、山田勇磨,中村孝司、畠山浩人、林泰弘、梶本和昭、原島秀吉
    • Total Pages
      10
    • Publisher
      CMC出版
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Book] Adv Biochem Eng Biotechnol(A Novel Nonviral Gene Delivery System: Multifunctional Envelope-Type Nano Device.)2009

    • Author(s)
      H.Hatakeyama, H.Akita, K.Kogure, H.Harashima
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Book] Contrib Nephrol (Nonviral gene delivery)2008

    • Author(s)
      Akita H, Harashima H.
    • Total Pages
      19
    • Publisher
      KARGER
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Book] 分子薬物動態学(第17章高分子・遺伝子の体内動態の制御(細胞内動態を中心に))2008

    • Author(s)
      秋田英万、原島秀吉
    • Total Pages
      19
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Book] 1Pharmacokinetics of Gene Delivery in Cells. In Non-viral Gene Therapy: Gene Design and Delivery Edit. by Kazunari Taira, Kazunori Kataoka,2005

    • Author(s)
      H.Akita, I.A Khalil, K.Kogure, H.Harashima.
    • Total Pages
      19
    • Publisher
      Springer-Verlag Tokyo, Inc.
    • Data Source
      KAKENHI-PROJECT-17659039
  • [Book] "New Drug Delivery System and Application to Gene Therapy" Knaeblein, Muller(Eds. Modern Biopharmaceuticals.)2005

    • Author(s)
      K.Kogure, H.Akita, H.Kamiya, H.Harashima.
    • Total Pages
      15
    • Publisher
      Wiley-VCH
    • Data Source
      KAKENHI-PROJECT-17016005
  • [Book] 1Pharmacokinetics of Gene Delivery in Cells. In Non-viral Gene Therapy : Gene Design and Delivery(Edit. by Kazunari Taira, Kazunori Kataoka,)2005

    • Author(s)
      H.Akita, I.A Khalil, K.Kogure, H.Harashima.
    • Total Pages
      19
    • Publisher
      Springer-Verlag Tokyo, Inc.
    • Data Source
      KAKENHI-PROJECT-17016005
  • [Book] "New Drug Delivery System and Application to Gene Therapy" Knaeblein, Muller Eds. Modern Biopharmaceuticals.2005

    • Author(s)
      K.Kogure, H.Akita, H.Kamiya, H.Harashima.
    • Total Pages
      15
    • Publisher
      Wiley-VCH
    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Activation of Mitochondrial Oxygen Consumption Rate by Delivering Coenzyme Q10 to Mitochondria of Rat Skeletal Muscle Cell (L6)2024

    • Author(s)
      Sato Itsumi、Hibino Mitsue、Takeda Atsuhito、Harashima Hideyoshi、Yamada Yuma
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: - Issue: 7 Pages: 1836-1843

    • DOI

      10.1016/j.xphs.2024.01.020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-23H00541
  • [Journal Article] Human cardiosphere-derived cells with activated mitochondria for better myocardial regenerative therapy2024

    • Author(s)
      Shiraishi Masahiro、Sasaki Daisuke、Hibino Mitsue、Takeda Atsuhito、Harashima Hideyoshi、Yamada Yuma
    • Journal Title

      Journal of Controlled Release

      Volume: 367 Pages: 486-499

    • DOI

      10.1016/j.jconrel.2024.01.058

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-23H00541
  • [Journal Article] Development of a Mitochondrial Targeting Lipid Nanoparticle Encapsulating Berberine2023

    • Author(s)
      Hori Ikuma、Harashima Hideyoshi、Yamada Yuma
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 2 Pages: 903-903

    • DOI

      10.3390/ijms24020903

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19928, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H04523
  • [Journal Article] Harnessing Topology and Stereochemistry of Glycidylamine‐Derived Lipid Nanoparticles for in Vivo mRNA Delivery to Immune Cells in Spleen and Their Application for Cancer Vaccination2023

    • Author(s)
      Abd Elwakil Mahmoud M.、Suzuki Ryota、Khalifa Alaa M.、Elshami Rania M.、Isono Takuya、Elewa Yaser H.A.、Sato Yusuke、Nakamura Takashi、Satoh Toshifumi、Harashima Hideyoshi
    • Journal Title

      Advanced Functional Materials

      Volume: 33 Issue: 45 Pages: 1-12

    • DOI

      10.1002/adfm.202303795

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23KJ0024, KAKENHI-PROJECT-22K19907, KAKENHI-PROJECT-23H05451
  • [Journal Article] Self-homing nanocarriers for mRNA delivery to the activated hepatic stellate cells in liver fibrosis.2023

    • Author(s)
      Mahmoud A. Younis; Yusuke Sato; Yaser H.A. Elewa; Yasuhiro Kon; Hideyoshi Harashima.
    • Journal Title

      Journal of Controlled Release

      Volume: 353 Pages: 685-698

    • DOI

      10.1016/j.jconrel.2022.12.020

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21F21105
  • [Journal Article] Genetically engineered transfusable platelets using mRNA lipid nanoparticles2023

    • Author(s)
      Leung Jerry、Strong Colton、Badior Katherine E.、Robertson Madelaine、Wu Xiaowu、Meledeo Michael A.、Kang Emma、Paul Manoj、Sato Yusuke、Harashima Hideyoshi、Cap Andrew P.、Devine Dana V.、Jan Eric、Cullis Pieter R.、Kastrup Christian J.
    • Journal Title

      Science Advances

      Volume: 9 Issue: 48

    • DOI

      10.1126/sciadv.adi0508

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Journal Article] A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury2023

    • Author(s)
      Hibino Mitsue、Maeki Masatoshi、Tokeshi Manabu、Ishitsuka Yoichi、Harashima Hideyoshi、Yamada Yuma
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 6961-6961

    • DOI

      10.1038/s41598-023-33893-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19928, KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-23H00541
  • [Journal Article] Reprogramming activated hepatic stellate cells by siRNA-loaded nanocarriers reverses liver fibrosis in mice2023

    • Author(s)
      Younis Mahmoud A.、Sato Yusuke、Elewa Yaser H.A.、Harashima Hideyoshi
    • Journal Title

      Journal of Controlled Release

      Volume: 361 Pages: 592-603

    • DOI

      10.1016/j.jconrel.2023.08.021

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Journal Article] On the size-regulation of RNA-loaded lipid nanoparticles synthesized by microfluidic device2022

    • Author(s)
      Okuda Kento、Sato Yusuke、Iwakawa Kazuki、Sasaki Kosuke、Okabe Nana、Maeki Masatoshi、Tokeshi Manabu、Harashima Hideyoshi
    • Journal Title

      Journal of Controlled Release

      Volume: 348 Pages: 648-659

    • DOI

      10.1016/j.jconrel.2022.06.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Journal Article] Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect2022

    • Author(s)
      Daisuke Sasaki, Jiro Abe, Atsuhito Takeda, Hideyoshi Harashima and Yuma Yamada
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 4344-4357

    • DOI

      10.1038/s41598-022-08583-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08529, KAKENHI-PROJECT-20K21872, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H04523
  • [Journal Article] Intravenous liposomal vaccine enhances CTL generation, but not until antigen presentation2022

    • Author(s)
      Nakamura Takashi、Haloho Sion Elisabeth Elfainatur、Harashima Hideyoshi
    • Journal Title

      Journal of Controlled Release

      Volume: 343 Pages: 1-12

    • DOI

      10.1016/j.jconrel.2022.01.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Journal Article] Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines2022

    • Author(s)
      Nakamura Takashi、Sato Yusuke、Yamada Yuma、Abd Elwakil Mahmoud M.、Kimura Seigo、Younis Mahmoud A.、Harashima Hideyoshi
    • Journal Title

      Advanced Drug Delivery Reviews

      Volume: 188 Pages: 114417-114417

    • DOI

      10.1016/j.addr.2022.114417

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03373, KAKENHI-PROJECT-20H04523, KAKENHI-PROJECT-21F21105, KAKENHI-PROJECT-21J10047
  • [Journal Article] mRNA-Loaded Lipid Nanoparticles Targeting Immune Cells in the Spleen for Use as Cancer Vaccines2022

    • Author(s)
      Shimosakai Ryoya、Khalil Ikramy A.、Kimura Seigo、Harashima Hideyoshi
    • Journal Title

      Pharmaceuticals

      Volume: 15 Issue: 8 Pages: 1017-1017

    • DOI

      10.3390/ph15081017

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-21J10047
  • [Journal Article] Clinical translation of nanomedicines: Challenges, opportunities, and keys2022

    • Author(s)
      Mahmoud A. Younis, Hesham M. Tawfeek, Ahmed A. H. Abdellatif, Jelan A. Abdel-Aleem, Hideyoshi Harashima
    • Journal Title

      Advanced Drug Delivery Reviews

      Volume: 181 Pages: 114083-114083

    • DOI

      10.1016/j.addr.2021.114083

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21F21105
  • [Journal Article] mRNA-Loaded Lipid Nanoparticles Targeting Dendritic Cells for Cancer Immunotherapy2022

    • Author(s)
      Sasaki Kosuke、Sato Yusuke、Okuda Kento、Iwakawa Kazuki、Harashima Hideyoshi
    • Journal Title

      Pharmaceutics

      Volume: 14 Issue: 8 Pages: 1572-1572

    • DOI

      10.3390/pharmaceutics14081572

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Journal Article] Combined nano cancer immunotherapy based on immune status in a tumor microenvironment2022

    • Author(s)
      Nakamura Takashi、Kawakami Kyoko、Nomura Momoka、Sato Yusuke、Hyodo Mamoru、Hatakeyama Hiroto、Hayakawa Yoshihiro、Harashima Hideyoshi
    • Journal Title

      Journal of Controlled Release

      Volume: 345 Pages: 200-213

    • DOI

      10.1016/j.jconrel.2022.03.026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03387, KAKENHI-PROJECT-19H01170
  • [Journal Article] Fine‐tuning the encapsulation of a photosensitizer in nanoparticles reveals the relationship between internal structure and phototherapeutic effects2022

    • Author(s)
      Kubota Fumika、Satrialdi、Takano Yuta、Maeki Masatoshi、Tokeshi Manabu、Harashima Hideyoshi、Yamada Yuma
    • Journal Title

      Journal of Biophotonics

      Volume: 16 Issue: 3

    • DOI

      10.1002/jbio.202200119

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H04523, KAKENHI-PROJECT-21K19036, KAKENHI-PROJECT-23K21067
  • [Journal Article] Novel lipid combination for delivery of plasmid DNA to immune cells in the spleen2021

    • Author(s)
      Kimura Seigo、Khalil Ikramy A.、Elewa Yaser H.A.、Harashima Hideyoshi
    • Journal Title

      Journal of Controlled Release

      Volume: 330 Pages: 753-764

    • DOI

      10.1016/j.jconrel.2021.01.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07420, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-21J10047
  • [Journal Article] The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines.2021

    • Author(s)
      Nakamura T, Nakade T, Yamada K, Sato Y, Harashima H
    • Journal Title

      Int J Pharm

      Volume: 609 Pages: 121140-121140

    • DOI

      10.1016/j.ijpharm.2021.121140

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H03373
  • [Journal Article] Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations2021

    • Author(s)
      Abbasi S, Higashino H, Sato Y, Minami K, Kataoka M, Yamashita S, Harashima H
    • Journal Title

      Mol Pharm

      Volume: 18 Issue: 9 Pages: 3181-3189

    • DOI

      10.1021/acs.molpharmaceut.1c00197

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Journal Article] GALA-Modified Lipid Nanoparticles for the Targeted Delivery of Plasmid DNA to the Lungs.2021

    • Author(s)
      Hagino Y, Khalil IA, Kimura S, Kusumoto K, Harashima H
    • Journal Title

      Mol Pharm.

      Volume: 18 Issue: 3 Pages: 878-888

    • DOI

      10.1021/acs.molpharmaceut.0c00854

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-21J10047
  • [Journal Article] Validation of the mitochondrial delivery of vitamin B1 to enhance ATP production using SH-SY5Y cells2021

    • Author(s)
      Yamada Y, Ishimaru T, Ikeda K, Harashima H
    • Journal Title

      J. Pharm. Sci.

      Volume: 111 Issue: 2 Pages: 432-439

    • DOI

      10.1016/j.xphs.2021.08.033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H04523
  • [Journal Article] STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation.2021

    • Author(s)
      Nakamura T, Sato T, Endo R, Sasaki S, Takahashi N, Sato Y, Hyodo M, Hayakawa Y, Harashima H.
    • Journal Title

      J Immunotherapy Cancer

      Volume: 9 Issue: 7 Pages: e002852-e002852

    • DOI

      10.1136/jitc-2021-002852

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H03373
  • [Journal Article] Engineered e-decalactone lipomers by-pass the liver to selectively in vivo deliver mRNA to the lungs without targeting ligands2021

    • Author(s)
      Elwakil A, Gao T, Isono T, Sato Y, Elewa Y, Satoh T, Harashima H,
    • Journal Title

      Mater Horizons

      Volume: 8 Issue: 8 Pages: 2251-2259

    • DOI

      10.1039/d1mh00185j

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20J20737
  • [Journal Article] Development of a nanoparticle that releases nucleic acids in response to a mitochondrial environment.2020

    • Author(s)
      Yamada Y, Fukuda Y, Sasaki D, Maruyama M, Harashima H
    • Journal Title

      Mitochondrion

      Volume: 52 Pages: 67-74

    • DOI

      10.1016/j.mito.2020.02.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-19H01170
  • [Journal Article] Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles2020

    • Author(s)
      Sato Y, Okabe N, Note Y, Hashiba K, Maeki M, Tokeshi M, Harashima H
    • Journal Title

      Acta Biomaterialia

      Volume: 102 Pages: 341-350

    • DOI

      10.1016/j.actbio.2019.11.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
  • [Journal Article] Lipid nanoparticles fuse with cell membranes of immune cells at low temperatures leading to the loss of transfection activity2020

    • Author(s)
      Nakamura T, Yamada K, Sato Y, Harashima H.
    • Journal Title

      Int J Pharm.

      Volume: 587 Pages: 119652-119652

    • DOI

      10.1016/j.ijpharm.2020.119652

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Journal Article] The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution2020

    • Author(s)
      Nakamura Takashi, Kawai Minori, Sato Yusuke, Maeki Masatoshi, Tokeshi Manabu, Harashima Hideyoshi
    • Journal Title

      Molecular Pharmaceutics

      Volume: 17 Issue: 3 Pages: 944-953

    • DOI

      10.1021/acs.molpharmaceut.9b01182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03974, KAKENHI-PROJECT-18K19889, KAKENHI-PROJECT-19H01170
  • [Journal Article] The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery.2020

    • Author(s)
      Hashiba A, Toyooka M, Sato Y, Maeki M, Tokeshi M, Harashima H.
    • Journal Title

      J Control Release.

      Volume: 327 Pages: 467-476

    • DOI

      10.1016/j.jconrel.2020.08.031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Journal Article] Validation of a mitochondrial RNA therapeutic strategy using fibroblasts from a Leigh syndrome patient with a mutation in the mitochondrial ND3 gene2020

    • Author(s)
      Yamada Y, Somiya K, Miyauchi A, Osaka H, Harashima H
    • Journal Title

      Sci. Rep

      Volume: - Issue: 1 Pages: 7511-7511

    • DOI

      10.1038/s41598-020-64322-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H03648, KAKENHI-PROJECT-20H04523
  • [Journal Article] A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes.2019

    • Author(s)
      Santiwarangkool S, Akita H, Khalil IA, Abd Elwakil MM, Sato Y, Kusumoto K, Harashima H.
    • Journal Title

      J Control Release.

      Volume: 307 Pages: 55-63

    • DOI

      10.1016/j.jconrel.2019.06.009

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Journal Article] A Multifunctional Lipid-Based Nanodevice for the Highly Specific Codelivery of Sorafenib and Midkine siRNA to Hepatic Cancer Cells.2019

    • Author(s)
      Younis MA, Khalil IA, Abd Elwakil MM, Harashima H
    • Journal Title

      Mol Pharm.

      Volume: 16 Issue: 9 Pages: 4031-4044

    • DOI

      10.1021/acs.molpharmaceut.9b00738

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Journal Article] Spleen selective enhancement of transfection activities of plasmid DNA driven by octaarginine and an ionizable lipid and its implications for cancer immunization.2019

    • Author(s)
      Kimura S, Khalil IA, Elewa YHA, Harashima H
    • Journal Title

      J Control Release.

      Volume: 313 Pages: 70-79

    • DOI

      10.1016/j.jconrel.2019.09.009

    • NAID

      120006896748

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Journal Article] Targeted mitochondrial delivery of antisense RNA-containing nanoparticles by a MITO-Porter for safe and efficient mitochondrial gene silencing.2019

    • Author(s)
      396.Kawamura E, Hibino M, Harashima H, Yamada Y.
    • Journal Title

      Mitochondrion.

      Volume: 28 Pages: 178-188

    • DOI

      10.1016/j.mito.2019.08.004

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H02094
  • [Journal Article] Recent advances in the targeting of systemically administered non-viral gene delivery systems.2019

    • Author(s)
      Khalil IA, Sato Y, Harashima H.
    • Journal Title

      Expert Opin Drug Deliv.

      Volume: 16 Issue: 10 Pages: 1037-1050

    • DOI

      10.1080/17425247.2019.1656196

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
  • [Journal Article] Innovative nanotechnologies for enhancing nucleic acids/gene therapy: Controlling intracellular trafficking to targeted biodistribution2019

    • Author(s)
      Nakamura Takashi, Yamada Yuma, Sato Yusuke, Khalil A Ikramy, Harashima Hideyoshi
    • Journal Title

      Biomaterials

      Volume: 218 Pages: 119329-119329

    • DOI

      10.1016/j.biomaterials.2019.119329

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19888, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-17H03974, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
  • [Journal Article] A nanocarrier system for the delivery of nucleic acids targeted to a pancreatic beta cell line2014

    • Author(s)
      Yamada Y., Tabata M., Yasuzaki Y., Nomura M., Shibata A., Ibayashi Y., Taniguchi Y., Sasaki S., Harashima H.
    • Journal Title

      Biomaterials

      Volume: 35 Issue: 24 Pages: 6430-6438

    • DOI

      10.1016/j.biomaterials.2014.04.017

    • NAID

      120005512023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-26461383
  • [Journal Article] Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle.2014

    • Author(s)
      Hattori Y, Morita, D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S, Sugita M.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 289(22) Issue: 22 Pages: 15405-12

    • DOI

      10.1074/jbc.m114.566489

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J04754, KAKENHI-PROJECT-14J03573, KAKENHI-PROJECT-24390255, KAKENHI-PROJECT-25460543, KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-26670213, KAKENHI-PROJECT-26860323
  • [Journal Article] Hepatic Monoacylglycerol 0-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes2014

    • Author(s)
      Yasuhiro Hayashi, Erina Suemitsu, Kazuaki Kajimoto, Yusuke Sato, Afsana Akhter, Yu Sakurai, Hiroto Hatakeyama, Mamoru Hyodo, Noritada Kaji, Yoshinobu Baba, Hideyoshi Harashima
    • Journal Title

      Mol. Ther. Nucleic Acids

      Volume: 3 Pages: e154-e154

    • DOI

      10.1038/mtna.2014.4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502
  • [Journal Article] RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system2014

    • Author(s)
      Yu Sakurai, Hiroto Hatakeyama, Yusuke Sato, Mamoru Hyodo, Hidetaka Akita, Noritaka Ohga, Kyoko Hida, Hideyoshi Harashima
    • Journal Title

      J. Control. Release

      Volume: 173 Pages: 110-118

    • DOI

      10.1016/j.jconrel.2013.10.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-25462909, KAKENHI-PROJECT-25893001, KAKENHI-PROJECT-26830101
  • [Journal Article] SMAD2 disruption in meuse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sengitive K+ channel activity.2014

    • Author(s)
      Nomura M, Zhu HL, Wang L, Morinaga H, Takayanagi R, Teramoto N.
    • Journal Title

      Diabetologia

      Volume: 57 Issue: 1 Pages: 157-166

    • DOI

      10.1007/s00125-013-3062-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-12F02426, KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23390247, KAKENHI-PROJECT-23591356, KAKENHI-PROJECT-26282148, KAKENHI-PROJECT-26461383
  • [Journal Article] Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide2013

    • Author(s)
      Eriko Kawamura, Yuma Yamada, Yukari Yasuzaki, Mamoru Hyodo and Hideyoshi Harashima.
    • Journal Title

      Journal of bioscience and bioengineering

      Volume: 116(5) Issue: 5 Pages: 634-637

    • DOI

      10.1016/j.jbiosc.2013.05.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J05438, KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
  • [Journal Article] An approach to transgene expression in liver endothelial cells using a liposome-based gene vector coated with hyaluronic acid2013

    • Author(s)
      Yamada Y, Hashida M, Hayashi Y, Tabata M, Hyodo M, Ara MN, Ohga N, Hida K, Harashima H.
    • Journal Title

      J Pharm Sci. (Wiley)

      Volume: 102 Pages: 3119-27

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Journal Article] Investigation of siRNA nanoparticle formation using mono-cationic detergents and its use in gene silencing in human HeLa cells2013

    • Author(s)
      Yamada Y, Suzuki R, Harashima H.
    • Journal Title

      Cancers (MDPI)

      Volume: 5 Issue: 4 Pages: 1413-25

    • DOI

      10.3390/cancers5041413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
  • [Journal Article] A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication2013

    • Author(s)
      Hossen MN, Kajimoto K, Akita H, Hyodo M, Harashima H.
    • Journal Title

      J. Control. Release

      Volume: 171 Issue: 2 Pages: 104-12

    • DOI

      10.1016/j.jconrel.2013.07.013

    • NAID

      120005365904

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Journal Article] The transfection activity of R8-modified nanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine2013

    • Author(s)
      Toriyabe N, Hayashi Y, Harashima H.
    • Journal Title

      Biomaterials. (Elsevier)

      Volume: 34 Issue: 4 Pages: 1337-43

    • DOI

      10.1016/j.biomaterials.2012.10.043

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23790038
  • [Journal Article] The transfection activity of R8-modified nanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine2013

    • Author(s)
      Toriyabe N, Hayashi Y, Harashima H
    • Journal Title

      Biomaterials

      Volume: 34(4) Issue: 6 Pages: 1337-1343

    • DOI

      10.1016/j.biomaterials.2012.11.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells2013

    • Author(s)
      Yamada Y, Nakamura K, Furukawa R, Kawamura E, Moriwaki T, Matsumoto K, Okuda K, Shindo M, Harashima H.
    • Journal Title

      J Pharm Sci. (Wiley)

      Volume: 102 Pages: 1008-15

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Journal Article] Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier.2013

    • Author(s)
      Yamada Y, Harashima H.
    • Journal Title

      Mitochondrion. (Elsevier)

      Volume: 13 Issue: 5 Pages: 526-32

    • DOI

      10.1016/j.mito.2012.09.001

    • NAID

      120005394544

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053
  • [Journal Article] A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence2013

    • Author(s)
      Akhter A, Hayashi Y, Sakurai Y, Ohga N, Hida K, Harashima H.
    • Journal Title

      Int J Pharm.

      Volume: 456 Issue: 1 Pages: 195-201

    • DOI

      10.1016/j.ijpharm.2013.07.068

    • NAID

      120005394547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-25462909
  • [Journal Article] Th1-skewed tissue responses to a mycolyl glycolipid in mycobacteria-infected rhesus macaques.2013

    • Author(s)
      Morita D, Miyamoto A, Hattori Y, Komori T, Nakamura T, lgarashi T, Harashima H, Sugita M
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 441(1) Issue: 1 Pages: 108-113

    • DOI

      10.1016/j.bbrc.2013.10.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J04754, KAKENHI-PROJECT-24390255
  • [Journal Article] Gene Silencing via RNAi and siRNA quantification in Tumor Tissue using MEND, a Liposomal siRNA Delivery System2013

    • Author(s)
      Sakurai Y, Hatakeyama H, Sato Y, Hyodo M, Akita H, Harashima H
    • Journal Title

      Molecular Therapy

      Volume: (印刷中) Issue: 6 Pages: 1195-203

    • DOI

      10.1038/mt.2013.57

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J02352, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502
  • [Journal Article] Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells.2013

    • Author(s)
      Yamada Y, Nakamura K, Furukawa R, Kawamura E, Moriwaki T, Matsumoto K, Okuda K, Shindo M, Harashima H.
    • Journal Title

      J Pharm Sci.

      Volume: 102 Issue: 3 Pages: 1008-1015

    • DOI

      10.1002/jps.23442

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-24659007, KAKENHI-PUBLICLY-24106731
  • [Journal Article] Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter2013

    • Author(s)
      Kawamura E, Yamada Y, Harashima H.
    • Journal Title

      Mitochondrion

      Volume: 13 Pages: 610-4

    • NAID

      120005460249

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Journal Article] Particle tracking analysis for the intracellular trafficking of nanoparticles modified with African swine fever virus protein p54-derived peptide2013

    • Author(s)
      Akita H, Enoto K, Tanaka H, Harashima H
    • Journal Title

      Molecular Therapy

      Volume: 21(2) Issue: 2 Pages: 309-317

    • DOI

      10.1038/mt.2012.235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] Development of a Novel Drug Delivery System consisting of an Antitumor Agent Tocopheryl Succinate2012

    • Author(s)
      Hama S, Utsumi S, Fukuda Y, Nakayama K, Okamura Y, Tsuchiya H, Fukuzawa K, Harashima H, Kogure K
    • Journal Title

      Journal of Control release

      Volume: 161(3) Issue: 3 Pages: 843-851

    • DOI

      10.1016/j.jconrel.2012.05.031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23390014
  • [Journal Article] Stearylated INF7 peptide enhances endosomal escape and gene expression of PEGylated nanoparticles both in vitro and in vivo2012

    • Author(s)
      El-Sayed A, Masuda T, Akita H, Harashima H
    • Journal Title

      J Pharm Sci.

      Volume: 101(2) Issue: 2 Pages: 879-882

    • DOI

      10.1002/jps.22807

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10F00421, KAKENHI-PROJECT-22229001
  • [Journal Article] Post-nuclear gene delivery events for transgene expression by biocleavable polyrotaxanes2012

    • Author(s)
      Y.Yamada, T.Nomura, H.Harashima, A.Yamashita, N.Yui
    • Journal Title

      Biomaterials

      Volume: 33 Issue: 15 Pages: 3952-3958

    • DOI

      10.1016/j.biomaterials.2012.01.049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053, KAKENHI-PLANNED-23107004
  • [Journal Article] The manner in which DNA is packaged with TFAM has an impact on transcription activation and inhibition2012

    • Author(s)
      Furukawa R, Yamada Y, Matsushima Y, Goto Y-I, Harashima H.
    • Journal Title

      FEBS open bio.

      Volume: 2 Issue: 1 Pages: 145-150

    • DOI

      10.1016/j.fob.2012.06.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
  • [Journal Article] Different mechanisms for nanoparticle formation between pDNA and siRNA using Polyrotaxane as the polycation2012

    • Author(s)
      Y.Yamada, M.Hashida, T.Nomura, H.Harashima, Y Yamasaki, K.Kataoka, A.Yamashita, R.Katoono, N.Yui
    • Journal Title

      ChemPhysChem

      Volume: 13(5) Issue: 5 Pages: 1161-1165

    • DOI

      10.1002/cphc.201100800

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PLANNED-23107004, KAKENHI-PROJECT-23680053
  • [Journal Article] Fabrication of functionalized double-lamellar multifunctional envelope-type nanodevices using a microfluidic chip with achaotic mixer array2012

    • Author(s)
      Kitazoe K, Park YS, Kaji N, Okamoto Y, Tokeshi M, Kogure K, Harashima H, Baba Y
    • Journal Title

      PLoS One

      Volume: 7(6)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] Delivery of bioactive molecules to the mitochondrial genome using a membrane-fusing, liposome-based carrier, DF-MITO-Porter2012

    • Author(s)
      Y.Yamada, H.Harashima
    • Journal Title

      Biomaterials

      Volume: 33(5) Issue: 5 Pages: 1589-1595

    • DOI

      10.1016/j.biomaterials.2011.10.082

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
  • [Journal Article] CREB-binding protein transcription activation domain for enhanced transgene expression by a positive feedback system2012

    • Author(s)
      G. Kanda, H. Ochiai, H. Harashima, and H. Kamiya
    • Journal Title

      J. Biotechnol

      Volume: 157(# 1) Issue: 1 Pages: 7-11

    • DOI

      10.1016/j.jbiotec.2011.09.016

    • NAID

      120003811532

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
  • [Journal Article] A Multifunctional Envelope-type Nanodevice for Use in Nanomedicine: Concept and Applications2012

    • Author(s)
      Nakamura T, Akita H, Yamada Y, Hatakeyama H, Harashima H
    • Journal Title

      Acc Chem Res

      Volume: 45(7) Issue: 7 Pages: 1113-1121

    • DOI

      10.1021/ar200254s

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PUBLICLY-24107502
  • [Journal Article] Effect of the Anchor in Polyethylene Glycol-Lipids on the Transfection Activity of PEGylated Cationic Liposomes Encapsulating DNA2012

    • Author(s)
      Kusumoto K, Akita H, El-Sayed A, Harashima H
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Issue: 4 Pages: 445-448

    • DOI

      10.1248/bpb.35.445

    • NAID

      130001872189

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10F00421, KAKENHI-PROJECT-22229001
  • [Journal Article] Noninvasive and efficient transdermal delivery of CpGoligodeoxynucleotide for cancer immunotherapy2011

    • Author(s)
      Kigasawa K, Kajimoto K, Nakamura T, Hama S, Kanamura K, Harashima H, Kogure K
    • Journal Title

      J Control Release

      Volume: 150(3) Issue: 3 Pages: 256-265

    • DOI

      10.1016/j.jconrel.2011.01.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] Improving in vivo hepatic transfection activity by controlling intracellular trafficking : the function of GALA and maltotriose2011

    • Author(s)
      Akita H, Masuda T, Nishio T, Niikura K, Ijiro K, Harashima H
    • Journal Title

      Mol Pharm

      Volume: 8(4) Issue: 4 Pages: 1436-1442

    • DOI

      10.1021/mp200189s

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-22350076, KAKENHI-PROJECT-22655050, KAKENHI-PROJECT-22655059
  • [Journal Article] KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011

    • Author(s)
      Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
    • Journal Title

      Biomaterials

      Volume: 32(26) Issue: 26 Pages: 6342-6350

    • DOI

      10.1016/j.biomaterials.2011.05.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-22659006
  • [Journal Article] Dual imaging of mRNA and protein production : an investigation of the mechanism of heterogeneity in cationic lipid-mediated transgene expression2011

    • Author(s)
      Akita H, Umetsu Y, Kurihara D, Harashima H
    • Journal Title

      Int J Pharm

      Volume: 415(1-2) Issue: 1-2 Pages: 218-220

    • DOI

      10.1016/j.ijpharm.2011.05.051

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] Glycerol monomycolate, a latent tuberculosis-associated mycobacterial lipid, induces eosinophilic hypersensitivity responses in guinea pigs. Biochem2011

    • Author(s)
      Hattori Y, Matsunaga I, Komori T, UrakawaT, Nakamura T, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
    • Journal Title

      Biophys. Res. Commun

      Volume: 409(2) Pages: 304-307

    • Data Source
      KAKENHI-PROJECT-21390304
  • [Journal Article] A designed curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver2011

    • Author(s)
      S. Fukunaga, G. Kanda, J. Tanase, H. Harashima, T. Ohyama, and H. Kamiya
    • Journal Title

      Gene Ther

      Volume: (in press) Issue: 8 Pages: 828-835

    • DOI

      10.1038/gt.2011.127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
  • [Journal Article] Effects of insulator cHS4 on transgene expression from plasmid DNA in a positive feedback system2011

    • Author(s)
      H. Ochiai, H. Harashima, and H. Kamiya
    • Journal Title

      J. Biosci. Bioengng

      Volume: 112(# 5) Issue: 5 Pages: 432-434

    • DOI

      10.1016/j.jbiosc.2011.07.001

    • NAID

      110008761503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
  • [Journal Article] Functional improvement of an I.RQ-PEG-MEND for delivering genes to the lung2011

    • Author(s)
      Ishitsuka T, Akita H, Harashima H
    • Journal Title

      J Control Release

      Volume: 154(1) Issue: 1 Pages: 77-83

    • DOI

      10.1016/j.jconrel.2011.05.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity2011

    • Author(s)
      Komori T, Nakamura T, Matsunaga I, Morita D, Hattori Y, Kuwata H, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
    • Journal Title

      J. Biol. Chem

      Volume: 286(19) Pages: 16800-16806

    • Data Source
      KAKENHI-PROJECT-21390304
  • [Journal Article] Dual function MITO-Porter, a nano carrier integrating both efficient cytoplasmic delivery and mitochondrial macromolecule delivery2011

    • Author(s)
      Yamada Yuma, Ryo Furukawa, Yukari Yasuzaki, Harashima Hideyoshi
    • Journal Title

      Molecular Therapy

      Volume: 19 Issue: 8 Pages: 1449-1456

    • DOI

      10.1038/mt.2011.99

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-11J05438, KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
  • [Journal Article] Correction of Frameshift Mutations with Tailed Duplex DNAs2011

    • Author(s)
      Y. Morita, H. Tsuchiya, H. Harashima, and H. Kamiya
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 34 Issue: 9 Pages: 1465-1468

    • DOI

      10.1248/bpb.34.1465

    • NAID

      130001872441

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
  • [Journal Article] KALA-modified multi-layered nano- particles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011

    • Author(s)
      Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
    • Journal Title

      Biomaterials

      Volume: 32(26) Pages: 6342-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Journal Article] Cell penetrating peptide-mediated systemic siRNA delivery to the liver2011

    • Author(s)
      Hayashi Y, Yamauchi J, Khalil IA, Kajimoto K, Akita H, Harashima H
    • Journal Title

      Int J Pharm

      Volume: 419(1-2) Issue: 1-2 Pages: 308-313

    • DOI

      10.1016/j.ijpharm.2011.07.038

    • NAID

      120003504743

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23790038
  • [Journal Article] A touch-and-go lipid wrapping technique in microfluidic channels for rapid fabrication of multifunctional envelope-type gene delivery nanodevices2011

    • Author(s)
      Kitazoe K, Wang J, Kaji N, Okamoto Y, Tokeshi M, Kogure K, Harashima H, Baba Y
    • Journal Title

      Lab Chip

      Volume: 11 Issue: 19 Pages: 3256-3262

    • DOI

      10.1039/c1lc20392d

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23390014
  • [Journal Article] A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response2011

    • Author(s)
      Hatakeyama H, Ito E, Yamamoto M, Akita H, Hayashi Y, Kajimoto K, Kaji N, Baba Y, Harashima H
    • Journal Title

      Mol Ther

      Volume: 19(8) Pages: 1487-98

    • NAID

      120003762627

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Journal Article] Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines : Programmed endosomal escape and dissociation.2010

    • Author(s)
      Akita H.; Kogure K.; Moriguchi R.; Nakamura Y.; Higashi T.; Nakamura T.; Serada S.; Fujimoto M.; Naka T.; Futaki S.; Harashima H.
    • Journal Title

      J.Control.Release 143

      Pages: 311-317

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Ornithine and tryptophan analogs as efficient polycations for short interference RNA delivery to tumor cells.2010

    • Author(s)
      Sato Y.; Hatakeyama H.; Harashima H.
    • Journal Title

      Biol Pharm Bull. 33

      Pages: 1246-1249

    • NAID

      130000300296

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake.2010

    • Author(s)
      Takara K.; Hatakeyama H.; Ohga N.; Hida K.; Harashima H.
    • Journal Title

      Int J Pharm. 396

      Pages: 143-148

    • NAID

      120003118155

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009

    • Author(s)
      Hatakeyama H.; Ito E.; Akita H.; Oishi M.; Nagasaki Y.; Futaki S.; Harashima H.
    • Journal Title

      J Control Release. 139

      Pages: 127-132

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a steo-wise membrane fusion process.2009

    • Author(s)
      H.Akita, A.Kudo, A.Minoura, M.Yamaguchi, IA.Khalil, R.Moriguchi, T.Masuda, R.Danev, K.Nagayama, K.Kogure, H.Harashima
    • Journal Title

      Biomaterials 30

      Pages: 2940-2949

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] Efficient siRNA delivery to tumor cells using the combination of octaarginine, GALA and tumor-specific, cleavable PEG system.2009

    • Author(s)
      Y.Sakurai, H.Hatakeyama, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
    • Journal Title

      Biol.Pharm.Bull. 32

      Pages: 928-932

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process2009

    • Author(s)
      H. Akita, A. Kudo, A. Minoura, M. Yamaguchi, I. A. Khalil, R. Moriguchi, T. Masuda, R. Danev, K. Nagayama, K. Kogure and H. Harashima.
    • Journal Title

      Biomaterials 30(15)

      Pages: 2940-9

    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system.2009

    • Author(s)
      Sakurai Y.; Hatakeyama H.; Akita H.; Oishi M.; Nagasaki Y.; Futaki S.; Harashima H.
    • Journal Title

      Biol Pharm Bull. 32

      Pages: 928-932

    • NAID

      130000117162

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process.2009

    • Author(s)
      H. Akita, A. Kudo, A. Minoura, M. Yamaguchi, I. A Khalil, R. Moriguchi, T. Masuda, R. Danev, K. Nagayama, K. Kogure, H. Harashima
    • Journal Title

      Biomaterials 30(15)

      Pages: 2940-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009

    • Author(s)
      H.Hatakeyama, E.Ito, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
    • Journal Title

      J.Control.Release 139

      Pages: 127-132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape.2009

    • Author(s)
      El-Sayed A, Masuda T, Khalil I, Akita H, Harashima H.
    • Journal Title

      J Control Release. 138(2)

      Pages: 160-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription.2009

    • Author(s)
      Masuda T, Akita H, Niikura K, Nishio T, Ukawa M, Enoto K, Danev R, Nagayama K, Ijiro K, Harashima H.
    • Journal Title

      Biomaterials 30(27)

      Pages: 4806-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Octaarginine- and octalysine- modified nanoparticles have different modes of endosomal escape.2008

    • Author(s)
      A.El-Sayed, IA.Khalil, K.Kogure, S.Futaki, H.Harashima
    • Journal Title

      J.Biol.Chem. 283

      Pages: 23450-23461

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergistic action of pH-sensitive fusogenic peptide derivatives.2008

    • Author(s)
      K. Sasaki, S. Chaki, Y. Nakamura, K. Kogure, H. Hamada, M. Ueno, S. Futaki, H. Harashima
    • Journal Title

      Anal Bioanal Chem 391(8)

      Pages: 2717-27

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Efficient MHC Class I Presentation by Controlled Intracellular Trafficking of Antigens in Octaarginine-modified Liposomes.2008

    • Author(s)
      T.Nakamura, R.Moriguchi, K.Kogure, N.Shastri, H.Harashima
    • Journal Title

      Mol.Ther. 16

      Pages: 1507-1514

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergisitic action of pH-sensitive fusogenic peptide derivatives.2008

    • Author(s)
      K.Sasaki, S.Chaki, Y.Nakamura, K.Kogure, H.Hamada, M.Ueno, S.Futaki, H.Harashima
    • Journal Title

      Anal.Bioanal.Chem. 391

      Pages: 2717-2727

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] Octaarginine-and octalysine-modified nanoparticles have different modes of endosomal escape.2008

    • Author(s)
      El-Sayed A.; Khalil IA.; Kogure K.; Futaki S.; Harashima H.
    • Journal Title

      J Biol Chem. 283

      Pages: 23450-23461

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergistic action of pH-sensitive fusogenic peptide derivatives. Anal.2008

    • Author(s)
      Sasaki K.; Kogure K.; Chaki S.; Nakamura Y.; Hamada H.; Ueno M.; Futaki S.; Harashima H.
    • Journal Title

      Bioanal.Chem. 391

      Pages: 2717-2727

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway.2008

    • Author(s)
      D. Mudhakir, H. Akita, E. Tan, H. Harashima
    • Journal Title

      J Control Release 125(2)

      Pages: 164-173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Octaarginine-and octalysine-modified nanoparticles have different modes of endosomal escape.2008

    • Author(s)
      A. El-Sayed, IA. Khalil, K. Kogure, S. Futaki, H. Harashima
    • Journal Title

      J Biol Chem 283(34)

      Pages: 23450-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] DNA microarray analysis on type 2 diabetes-related genes co-regulated between white blood cells and liver of diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Biol.2007

    • Author(s)
      Y. Hayashi, S. Iida, Y. Sato, A. Nakaya, A. Sawada, N. Kaji, H. Kamiya, Y. Baba, H. Harashima
    • Journal Title

      Pharm. Bull 30(4)

      Pages: 763-771

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA2007

    • Author(s)
      Nakamura, Y. ; Kogure, K. ; Futaki, S. ; Harashima, H.
    • Journal Title

      J. Cont. Rel. 119

      Pages: 360-367

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Tumor targeting of doxorubicin by anti MT1-MMP antibodymodified PEG liposomes.2007

    • Author(s)
      Hatakeyama H.; Akita H.; Ishida E.; Hashimoto K.; Kobayashi H.; Aoki T.; Yasuda J.; Obata K.; Kikuchi H.; Ishida T.; Kiwada H.; Harashima H.
    • Journal Title

      Int.J.Pharm. 342

      Pages: 194-200

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Octaarginine-modified envelope-type nanoparticles for gene delivery. Gene Therapy nanoparticles for gene delivery2007

    • Author(s)
      I. A. Khalil, K. Kogure, S. Futaki, S. Hama, H. Akita, K. Kataoka, and H. Harashima
    • Journal Title

      Gene Therapy 14(8)

      Pages: 682-9

    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA.2007

    • Author(s)
      Nakamura Y.; Kogure K.; Futaki S.; Harashima H.
    • Journal Title

      J.Cont.Rel. 119

      Pages: 360-367

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA.2007

    • Author(s)
      Y. Nakamura, K. Kogure, S. Futaki, H. Harashima
    • Journal Title

      J. Cont. Rel. 119(3)

      Pages: 360-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature.2006

    • Author(s)
      Iwasa A.; Akita H.; Khalil IA.; Kogure K.; Futaki S.; Harashima H.
    • Journal Title

      BBA-Biomembranes 1758

      Pages: 713-720

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Evaluation of the nuclear delivery and intra-nuclear transcription of the plasmid DNA condensed with m (mu) and NLS- m by cytoplasmic and nuclear microinjection : comparative study with poly L-lysine.2006

    • Author(s)
      H.Akita, M.Tanimoto, T.Masuda, K.Kogure, S.Futaki, H.Harashima.
    • Journal Title

      J.Gen.Med. 8・2

      Pages: 198-206

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] Non-linear pharmacodynamics in non-viral gene delivery system : Synergistic relationship between dose and nuclear transcription efficiency.2006

    • Author(s)
      R.Moriguchi, K.Kogure, H.Harashima.
    • Journal Title

      J.Cont.Re.l. 110・3

      Pages: 605-609

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression.2006

    • Author(s)
      I.A Khalil, K.Kogure, S.Futaki, H.Harashima.
    • Journal Title

      J.Biol.Chem. 281・6

      Pages: 3544-3551

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression.2006

    • Author(s)
      I.A Khalil, K.Kogure, S.Futaki, H.Harashima.
    • Journal Title

      J.Biol.Chem. 281・6

      Pages: 3544-5551

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Significant and prolonged antisense effect of multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide.2006

    • Author(s)
      Y.Nakamura, K.Kogure, Y.Yamada, H.Harashima.
    • Journal Title

      J.Pharm. Pharmacol. (in press)

    • NAID

      120000954675

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Genome wide expression analysis of white blood cells and liver of pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats using a cDNA microarray.2006

    • Author(s)
      S. Iida, Y. Sato, A. Nakaya, Y. Shinohara, Y. Hayashi, A. Sawada, H. Nagata, N. Kaji, H. Kamiya, Y. Baba, H. Harashima
    • Journal Title

      Biol. Pharm. Bull 29(12)

      Pages: 2451-9

    • NAID

      110006148670

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression2006

    • Author(s)
      1. I. A Khalil, K. Kogure, S. Futaki, and H. Harashima
    • Journal Title

      J. Biol. Chem. 281(6)

      Pages: 3544-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.2006

    • Author(s)
      Hatakeyama H.; Akita H.; Kogure K.; Oishi M.; Nagasaki Y.; Kihira Y.; Ueno M.; Kobayashi H.; Kikuchi H.; Harashima H.
    • Journal Title

      Gene Therapy 14

      Pages: 68-77

    • NAID

      110006402944

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy.2005

    • Author(s)
      Y.Yamada, Y.Shinohara, T.Kakudo, S.Chaki, S.Futaki, H.Kamiya, H.Harashima
    • Journal Title

      Int.J.Pharm. 303

      Pages: 1-7

    • NAID

      120003702858

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Pharmacokinetics And Brain Uptake Of Lactoferrin In Rats.2005

    • Author(s)
      B.Ji, J.Maeda, K.Inoue, H.Akita, H.Harashima, T.Suhara.
    • Journal Title

      Life Sciences 78・8

      Pages: 851-855

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] Kinetic analysys of protein production after DNA transfection.2005

    • Author(s)
      Y.Yamada, H.Kamiya, H.Harashima.
    • Journal Title

      Int.J.Pharm. 299

      Pages: 34-40

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Construction of multifunctional envelope-type nano device by a SUV^*-fusion method.2005

    • Author(s)
      K.Sasaki, K.Kogure, S.Chaki, Y.Kihira, M.Ueno, H.Harashima.
    • Journal Title

      Int.J.Pharm. 296・1-2

      Pages: 142-150

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Biodistribution of octaarginine modified lisposomes in mice.2005

    • Author(s)
      D.Mudhakir, H.Akita, I.A.Khalil, S.Futaki, H.Harashima.
    • Journal Title

      Drug metabolism and Pharmacokinetics 20・4

      Pages: 275-281

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] Development of an efficient method for packaging oligodeoxynucleotides in a condensed nano particle with a lipid-envelope structure.2005

    • Author(s)
      Y.Yamada, K.Kogure, Y.Nakamura, K.Inoue, H.Akita, F.Ngatsugi, S.Sasaki, T.Suhara, H.Harashima.
    • Journal Title

      Biol. Pharm. Bull. 28・10

      Pages: 1939-1942

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Construction of multifunctional envelope-type nano device by a SUV^*-fusion method.2005

    • Author(s)
      K.Sasaki, K.Kogure, S.Chaki, Y.Kihira, M.Ueno, H.Harashima.
    • Journal Title

      Int.J.Pharm. 296・1-2

      Pages: 142-150

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids.2005

    • Author(s)
      R.Moriguchi, K.Kogure H.Akita, S.Futaki, M.Miyagishi, K.Taira, H.Harashima
    • Journal Title

      Int.J.Pharm. 301

      Pages: 277-285

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids.2005

    • Author(s)
      R.Moriguchi, K.Kogure H.Akila, S.Futaki, M.Miyagishi, K.Taira, H.Harashima.
    • Journal Title

      Int.J.Pharm. 301

      Pages: 277-285

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Development of an efficient method for packaging oligodeoxynucleotides in a condensed nano particle with a lipid-envelope structure.2005

    • Author(s)
      Y.Yamada, K.Kogure, Y.Nakamura, K.Inoue, H.Akita, F.Ngatsugi, S.Sasaki, T.Suhara, H.Harashima.
    • Journal Title

      Biol.Pharm.Bull. 28・10

      Pages: 1939-1942

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] Evaluation of nuclear translocation and transcription of plasmid DNA condensed with protamine by microinjection : introduction of Nuclear Translocation score.2005

    • Author(s)
      T.Masuda, H.Akita, H.Harashima.
    • Journal Title

      FEBS Lett. 579・10

      Pages: 2143-2148

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article]

    • Author(s)
      H.Akita, K.Kogure, R.Moriguchi, Y.Nakamura, T.Higashi, T.Nakamura, S.Serada, M.Fujimoto, T.Naka, S.Futaki, H.Harashima
    • Journal Title

      J.Control.Release (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] Significant and prolonged antisense effect of multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide.

    • Author(s)
      Y.Nakamura, K.Kogure, Y.Yamada, H.Harashima.
    • Journal Title

      J.Pharm.Pharmacol. (in press)

    • NAID

      120000954675

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Patent] ミトコンドリアゲノム編集用脂質ナノ粒子2024

    • Inventor(s)
      山田勇磨、原島秀吉、佐藤悠介、渡慶次学、真栄城 正寿、他
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2024
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Patent] ミトコンドリアゲノム編集用脂質ナノ粒子2023

    • Inventor(s)
      山田勇磨、原島秀吉、佐藤悠介、石塚宣、野呂田楓、ほか
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-027872
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Patent] pH感受性カチオン性脂質及び脂質ナノ粒子2023

    • Inventor(s)
      佐藤悠介、伊藤里奈、鈴木裕一、原島秀吉
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-090454
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Patent] 双性イオンリン脂質化合物及びそれを含む脂質ナノ粒子2023

    • Inventor(s)
      佐藤悠介、原島秀吉
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-178361
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Patent] 脂質ナノ粒子2022

    • Inventor(s)
      佐藤悠介、原島秀吉、小沼はるの
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-060960
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Patent] Ligand-free In vivo Targeting of The Hepatic Stellate Cells for Robust and Selective Delivery of RNA therapeutics in Fibrotic Livers.2022

    • Inventor(s)
      MA. Younis, H. Harashima, et al.
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-121626
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-21F21105
  • [Patent] Lipid Nanoparticles and Pharmaceutical Compositions for the treatment of liver fibrosis.2022

    • Inventor(s)
      MA. Younis, H. Harashima, et al.
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21F21105
  • [Patent] 代謝改善剤2021

    • Inventor(s)
      西英一郎、岩﨑広高、大野美紀子、佐藤悠介、原島秀吉
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Patent] 脂質ナノ粒子2021

    • Inventor(s)
      佐藤悠介、佐々木宏輔、原島秀吉
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-085985
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Patent] 脂質ナノ粒子2021

    • Inventor(s)
      中村孝司、原島秀吉、佐藤悠介、山田小春、中出泰誠
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-023184
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Patent] 溶解剤2021

    • Inventor(s)
      原島秀吉、佐藤悠介、アッバシ サエド アムジャド ヨセフ、他
    • Industrial Property Rights Holder
      国立大学法人北海道大学、常翔学園
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Patent] 脂質ナノ粒子2020

    • Inventor(s)
      佐藤悠介、原島秀吉
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Patent] 肝細胞癌に有用な脂質ナノ粒子2020

    • Inventor(s)
      原島秀吉、マハムドヨニス、イクラミカリル
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Patent] 脂質ナノ粒子2019

    • Inventor(s)
      原島秀吉、イブラヒム イクラミ カリル、木村誠悟
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-116594
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Patent] 脂質膜構造体、脂質膜構造体の製造方法および1の目的物質を1枚の脂質膜で封入する方法2012

    • Inventor(s)
      原島秀吉、山田勇磨、鈴木亮佑
    • Industrial Property Rights Holder
      原島秀吉、山田勇磨、鈴木亮佑
    • Filing Date
      2012-02-24
    • Overseas
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Patent] 結合剤およびその利用2012

    • Inventor(s)
      原島秀吉、林泰弘、秋田英万、鳥谷部尚之、富樫亮平
    • Industrial Property Rights Holder
      原島秀吉、林泰弘、秋田英万、鳥谷部尚之、富樫亮平
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-174272
    • Filing Date
      2012-08-06
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Patent] 核移行性を有する脂質膜構造体2011

    • Inventor(s)
      原島秀吉、秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2011-04-10
    • Overseas
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Patent] 核内移行性を有する脂質膜構造体2011

    • Inventor(s)
      原島秀吉, 秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗
    • Industrial Property Rights Holder
      原島秀吉,秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗
    • Filing Date
      2011-04-20
    • Overseas
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Patent] 細胞内動態を改善したカチオン性脂質2011

    • Inventor(s)
      丹下耕太、新井将也、久保和弘、秋田英万、原島秀吉、畠山浩人、石破諒平、鵜川真実
    • Industrial Property Rights Holder
      丹下耕太、新井将也、久保和弘、秋田英万、原島秀吉、畠山浩人、石破諒平、鵜川真実
    • Industrial Property Number
      2011-252309
    • Filing Date
      2011-11-18
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Patent] 核内移行性を有する脂質膜構造体2011

    • Inventor(s)
      原島秀吉,秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗、権利者
    • Filing Date
      2011-04-20
    • Overseas
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Patent] 機能性ポリペプチド及び当該ポリペプチドで修飾された脂質膜構造体2010

    • Inventor(s)
      原島秀吉, 秋田英万, 畠山浩人, 他
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Number
      2010-039667
    • Filing Date
      2010-02-25
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Patent] 核内移行性を有する脂質膜構造体2010

    • Inventor(s)
      原島秀吉
    • Industrial Property Rights Holder
      国立大学法人北海道大学国立大学法人京都大学
    • Filing Date
      2010-04-21
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Patent] 機能性ポリペプチド及び当該ポリペプチドで修飾された脂質膜構造体2010

    • Inventor(s)
      原島秀吉、秋田英万、畠山浩人、他
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2010-02-25
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Patent] 核内移行性を有する脂質膜構造体2010

    • Inventor(s)
      原島秀吉
    • Industrial Property Rights Holder
      国立大学法人北海道大学国立大学法人京都大学
    • Filing Date
      2010-04-21
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Patent] 機能性ポリペプチドお呼び当該ポリペプチドで就職された脂質膜構造体2010

    • Inventor(s)
      原島秀吉, 秋田英万、榎戸薫、畠山浩人、桜井遊
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2010-02-25
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Patent] 脂質膜構造体に細胞透過能を付与するペプチドと結合した脂質を構成脂質として含む、細胞透過能を有する脂質膜構造体.2009

    • Inventor(s)
      原島秀吉, 秋田英万、藤原孝博
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2009-12-14
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Patent] 脂質膜構造体2009

    • Inventor(s)
      原島秀吉, 秋田英万、アイマンエルサイド、増田智也
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2009-03-23
    • Data Source
      KAKENHI-PROJECT-20659020
  • [Patent] 脂質膜構造体2009

    • Inventor(s)
      原島秀吉, 秋田英万、アイマンエルサイド、増田智也
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2009-03-23
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Patent] 核輸送性脂質膜構造体2009

    • Inventor(s)
      原島秀吉, 増田智也、秋田英万、西尾崇、新倉謙一、居城邦治
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2009-03-23
    • Data Source
      KAKENHI-PROJECT-20659020
  • [Patent] 高分子化合物またはその複合体の細胞透過性評価装置及びその細胞透過性評価方法.2009

    • Inventor(s)
      原島秀吉, 秋田英万、藤原孝博、田畑泰彦
    • Industrial Property Rights Holder
      北海道大学、京都大学
    • Filing Date
      2009-12-03
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Patent] 脂質膜構造体2009

    • Inventor(s)
      原島秀吉, 秋田英万、アイマンエルサイド、増田智也
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2009-03-23
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Patent] オリゴアルキレングリコール修飾された脂質膜構造体2008

    • Inventor(s)
      原島秀吉,増田智也、秋田英万、居城邦治、新倉謙一、西尾崇
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2008-04-25
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Patent] 腫瘍組織で選択的に分解性を示す血中滞留性素子2008

    • Inventor(s)
      秋田英万, 畠山浩人, 原島秀吉
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Filing Date
      2008-12-12
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Patent] 2型糖尿病診断用キット2008

    • Inventor(s)
      原島秀吉、紙谷浩之、桑島正道
    • Industrial Property Rights Holder
      北海道大学
    • Acquisition Date
      2008-11-14
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Patent] 2型糖尿病の診断方法2008

    • Inventor(s)
      原島秀吉, 紙谷浩之, 桑島正道
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2008-08-11
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Patent] 脂質膜構造体2008

    • Inventor(s)
      原島秀吉,増田智也、秋田英万、石原一彦、金野智浩
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2008-12-12
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Patent] 腫瘍選択的分解性を示す血中滞留性素子2007

    • Inventor(s)
      秋田 英万・畠山 浩人・長崎 幸夫・大石 基・菊池 寛・小林 英夫・原島 秀吉
    • Industrial Property Rights Holder
      北海道大学、筑波大学、塩野義製薬株式会社
    • Filing Date
      2007-07-25
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18015004
  • [Patent] 2型糖尿病診断剤2007

    • Inventor(s)
      原島秀吉、飯田慎也、紙谷浩之、林泰弘、馬場嘉信
    • Industrial Property Rights Holder
      北海道大学, 名古屋大学
    • Industrial Property Number
      2007-072563
    • Filing Date
      2007-03-20
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Patent] 目的物質をミトコンドリア内に送達可能な脂質膜構造体2006

    • Inventor(s)
      山田勇磨, 秋田英万, 小暮健太朗, 紙谷浩之, 原島秀吉, 菊池寛, 小林英夫
    • Industrial Property Rights Holder
      北海道大学, 第一製薬株式会社
    • Filing Date
      2006-03-09
    • Data Source
      KAKENHI-PROJECT-17659039
  • [Patent] 粒子を脂質膜で被覆する方法2006

    • Inventor(s)
      小暮健太朗、箕浦ありさ、原島秀吉
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2006-01-18
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Patent] 粒子を脂質膜で被覆する方法.2005

    • Inventor(s)
      小暮 健太朗, 箕浦 ありさ, 原島 秀吉
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Number
      2005-010998
    • Filing Date
      2005-01-18
    • Data Source
      KAKENHI-PROJECT-17016005
  • [Patent] 粒子を脂質膜で被覆する方法.2005

    • Inventor(s)
      小暮 健太朗, 箕浦 ありさ, 原島 秀吉
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Number
      2005-010998
    • Filing Date
      2005-01-18
    • Data Source
      KAKENHI-PROJECT-17659039
  • [Patent] 核酸の細胞内送達効率または細胞内発現効率を向上させた組成物.2005

    • Inventor(s)
      小暮 健太朗, 森口 留美子, 原島 秀吉
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Number
      2005-061677
    • Filing Date
      2005-03-04
    • Data Source
      KAKENHI-PROJECT-17016005
  • [Patent] 腫瘍組織で選択的に分解性を示す血中滞留性素子.2005

    • Inventor(s)
      秋田 英万, 畠山 浩人, 長崎 幸夫, 菊池 寛, 小林 英夫, 原島 秀吉
    • Industrial Property Rights Holder
      北海道大学, 第一製薬, 筑波大学
    • Industrial Property Number
      2005-050708
    • Filing Date
      2005-02-25
    • Data Source
      KAKENHI-PROJECT-17016005
  • [Patent] 目的物質をミトコンドリア内に送達可能な脂質膜構造体.2005

    • Inventor(s)
      山田 勇磨, 秋田 英万, 小暮 健太朗, 紙谷 浩之, 原島 秀吉, 菊池 寛, 小林 英夫
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Number
      2005-066385
    • Filing Date
      2005-03-09
    • Data Source
      KAKENHI-PROJECT-17659039
  • [Patent] リボソーム封入物質がエンドソームから脱出可能なリポソーム2004

    • Inventor(s)
      茶木 伸治, 小暮 健太朗, 二木 史朗, 原島 秀吉
    • Industrial Property Rights Holder
      科学技術振興機構
    • Industrial Property Number
      2004-205217
    • Filing Date
      2004-07-12
    • Data Source
      KAKENHI-PROJECT-16023201
  • [Patent] リポソーム封入物質がエンドソームから脱出可能なリポソーム2004

    • Inventor(s)
      茶木 伸治, 小暮 健太朗, 二木 史朗, 原島 秀吉
    • Industrial Property Rights Holder
      科学技術振興機構
    • Industrial Property Number
      2004-205217
    • Filing Date
      2004-07-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15300151
  • [Patent] 核移行性を有する二枚膜構造遺伝子封入体の構築技術2004

    • Inventor(s)
      原島 秀吉
    • Filing Date
      2004-03-24
    • Data Source
      KAKENHI-PROJECT-15300151
  • [Patent] 2型糖尿病の診断方法2004

    • Inventor(s)
      原島 秀吉, 佐藤 雄一郎, 馬場 嘉信
    • Industrial Property Rights Holder
      北海道TLO
    • Industrial Property Number
      2004-073597
    • Filing Date
      2004-03-15
    • Data Source
      KAKENHI-PROJECT-16012201
  • [Patent] 2型糖尿病の診断方法2004

    • Inventor(s)
      原島 秀吉, 佐藤 雄一郎, 馬場 嘉信
    • Industrial Property Rights Holder
      北海道TLO
    • Industrial Property Number
      2004-073597
    • Filing Date
      2004-03-15
    • Data Source
      KAKENHI-PROJECT-14657612
  • [Patent] 核移行能を有するポリアルギニン修飾リポソーム2004

    • Inventor(s)
      原島 秀吉, 二木 史朗, 小暮 健太朗
    • Industrial Property Rights Holder
      科学技術振興機構
    • Filing Date
      2004-10-01
    • Data Source
      KAKENHI-PROJECT-16023201
  • [Patent] 核移行能を有するポリアルギニン修飾リポソーム2003

    • Inventor(s)
      原島 秀吉, 二木 史朗, 小暮 健太朗
    • Industrial Property Rights Holder
      科学技術振興機構
    • Industrial Property Number
      2003-343857
    • Filing Date
      2003
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15300151
  • [Patent] 細胞に導入した核酸の標的オルガネラにおける局在量を定量する方法2003

    • Inventor(s)
      原島 秀吉, 秋田 英万
    • Industrial Property Rights Holder
      科学技術振興機構
    • Industrial Property Number
      2003-193038
    • Filing Date
      2003
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15300151
  • [Patent] SUV型リポソームの膜融合を利用した遺伝子等の新規封入技術

    • Inventor(s)
      原島 秀吉
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15300151
  • [Patent] 核移行性を有する二枚膜構造遺伝子封入体の構築技術

    • Inventor(s)
      原島 秀吉
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15300151
  • [Presentation] 腫瘍血管内皮細胞の機能制御と自然免疫活性化を起点とした新規がん治療法の開発2023

    • Author(s)
      上田智貴、中村孝司、遠藤力斗、佐藤悠介、原島秀吉
    • Organizer
      日本薬剤学会第38年会
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] 膜融合性を持つ新規中性リン脂質を用いた効率的なmRNA送達システムの開発2023

    • Author(s)
      岩川和樹,佐藤悠介,原島秀吉
    • Organizer
      第44回生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] An impact of helper lipids on extrahepatic delivery of nucleic acids based on ionizable cationic lipids2023

    • Author(s)
      Hideyoshi Harashima, Mahmoud Younis, Seigo Kimura, Yusuke Sato
    • Organizer
      Cold Spring Harbor Conferences Asia, The Now and Future of RNA Therapeutics
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] 脂質ナノ粒子製剤の粒子径制御と樹状細胞標的化2023

    • Author(s)
      佐藤悠介,奥田健斗,佐々木宏輔,岩川和樹,原島秀吉
    • Organizer
      日本核酸医薬学会第8回年会
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] 腫瘍血管破壊を誘導する新機軸がん治療法の開発2023

    • Author(s)
      中村孝司、遠藤力斗、上田智貴、佐藤悠介、原島秀吉
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] Ionizable cationic lipid libraryによる肝臓外核酸・遺伝子送達システムの開発:内因性のタンパク質を用いたアクティブターゲティングの可能性2023

    • Author(s)
      原島秀吉
    • Organizer
      日経バイオテク・プロフェッショナルセミナー、次世代の薬物送達技術を俯瞰する
    • Invited
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] Extrahepatic delivery of mRNA based on an ionizable cationic lipid library: from hepatocyte to activated stellate cells, from normal to disease state2023

    • Author(s)
      Hideyoshi Harashima, Mahmoud Younis, Seigo Kimura, Yusuke Sato
    • Organizer
      2nd Annual Next Generation Lipid-Based Nanoparticles Delivery Summit
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] マイクロ流体デバイスによる脂質ナノ粒子の粒径制御とin vivo RNA送達2023

    • Author(s)
      佐藤悠介、奥田健斗、岩川和樹、佐々木宏輔、原島秀吉
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] 対イオン脂質を用いた効率的なmRNA送達システムの開発2023

    • Author(s)
      鈴木裕一,佐藤悠介,原島秀吉
    • Organizer
      第39回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] 効率的な遺伝子発現を示す新規イオン化脂質の開発2023

    • Author(s)
      伊藤里奈,佐藤悠介,原島秀吉
    • Organizer
      日本核酸医薬学会第8回年会
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] 細胞内動態制御に基づいた遺伝子・核酸送達システムの創製とナノ医療への展開2023

    • Author(s)
      原島秀吉
    • Organizer
      日本薬学会学会賞受賞講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] 薬物速度論から細胞内動態制御へ、大学発革新的医薬品の創出へ2023

    • Author(s)
      原島秀吉
    • Organizer
      第21回東京理科大学DDSシンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] DDS製剤臨床応用の現在と将来展望2023

    • Author(s)
      原島秀吉
    • Organizer
      DDS製剤臨床応用FG
    • Invited
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] ナノDDSを基盤とした腫瘍血管破壊を誘導する新規がん治療法の開発2023

    • Author(s)
      遠藤力斗、中村孝司、上田智貴、佐藤悠介、原島秀吉
    • Organizer
      第39回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-23H05451
  • [Presentation] 側鎖の構造や置換位置の異なるポリ(ε-カプロラクトン) 誘導体の合成と核酸デリバリー材料への応用2022

    • Author(s)
      水上湧太、Mahmoud M. Abd Elwakil、佐藤悠介、磯野拓也、山本拓矢、田島健次、原島秀吉、佐藤敏文
    • Organizer
      第12回CSJ化学フェスタ
    • Data Source
      KAKENHI-PROJECT-22K19907
  • [Presentation] ポリ(ε-カプロラクトン) 誘導体を構成成分とする脂質ナノ粒子による肺・脾臓選択的mRNAデリバリー2022

    • Author(s)
      水上湧太、Mahmoud M. Abd Elwakil、佐藤悠介、磯野拓也、山本拓矢、田島健次、原島秀吉、佐藤敏文
    • Organizer
      日本化学会北海道支部2022年夏季研究発表会
    • Data Source
      KAKENHI-PROJECT-22K19907
  • [Presentation] Gene Therapy for the Future of Medicine.2022

    • Author(s)
      Mahmoud A. Younis, Hideyoshi Harashima.
    • Organizer
      A lecture presented to the students of Sapporo Kaisei Secondary School, Sapporo, Japan, the proceedings of Japan Society for the Promotion of Science (JSPS) Science Dialogue 2022
    • Invited
    • Data Source
      KAKENHI-PROJECT-21F21105
  • [Presentation] Tweaking Nanocarriers for Targeted RNA Therapeutics Delivery in Liver Diseases.2022

    • Author(s)
      Mahmoud A. Younis, Yusuke Sato, Hideyoshi Harashima.
    • Organizer
      7th Annual meeting of the Nucleic Acids Therapeutics Society of Japan
    • Data Source
      KAKENHI-PROJECT-21F21105
  • [Presentation] ミトコンドリアDDSを基盤とした遺伝子細胞治療への挑戦2022

    • Author(s)
      山田 勇磨、原島秀吉
    • Organizer
      第28回日本遺伝子細胞治療学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] 種々の側鎖構造を有するアミノ化ポリ(ε-カプロラクトン) 誘導体の合成と核酸デリバリー材料への応用2022

    • Author(s)
      水上湧太、Mahmoud M. Abd Elwakil、佐藤悠介、磯野拓也、山本拓矢、田島健次、原島秀吉、佐藤敏文
    • Organizer
      日本化学会北海道支部2022年夏季研究発表会
    • Data Source
      KAKENHI-PROJECT-22K19907
  • [Presentation] 治療用rRNA送達によるミトコンドリア遺伝子治療戦略の検証2022

    • Author(s)
      山田勇磨、丸山美菜子、原島秀吉
    • Organizer
      日本核酸医薬学会第7回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Different cellular responses to lipid-based carriers affect tissue/cell-selective gene delivery2022

    • Author(s)
      木村誠悟, 原島秀吉
    • Organizer
      日本核酸医薬学会第7年会
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Multifunctional Envelope-type Nano Device: from Controlled Intracellular Trafficking to Clinical Application for Nanomedicines2022

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      Liposome Research Days 2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Multifunctional Envelope-type Nano Device: from Controlled Intracellular Trafficking to Clinical Application for Nanomedicines2022

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      The 18th International Symposium on Recent Advances in Drug Delivery Systems
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Delivery of the Nanomedicines Beyond the Active Targeting; the Next Generation of RNA Therapeutics.2022

    • Author(s)
      Mahmoud A. Younis, Yusuke Sato, Hideyoshi Harashima.
    • Organizer
      The 7th Japan-Taiwan Joint Symposium For Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21F21105
  • [Presentation] On the mechanism of tissue-selective gene transfection by lipid-based carriers2022

    • Author(s)
      Seigo Kimura, Hideyoshi Harashima
    • Organizer
      Liposome Research Days 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] ポリ(ε-カプロラクトン) 誘導体を構成成分とする mRNA 搭載脂質ナノ粒子の in vivo デリバリー2022

    • Author(s)
      水上湧太、Mahmoud M. Abd Elwakil、佐藤悠介、磯野拓也、山本拓矢、田島健次、原島秀吉、佐藤敏文
    • Organizer
      第51回医用高分子シンポジウム
    • Data Source
      KAKENHI-PROJECT-22K19907
  • [Presentation] アミノ化ポリ(ε-カプロラクトン)誘導体をベースとした脂質ナノ粒子による肺・脾臓選択的 mRNA デリバリー2022

    • Author(s)
      水上湧太、Mahmoud M. Abd Elwakil、佐藤悠介、磯野拓也、山本拓矢、田島健次、原島秀吉、佐藤敏文
    • Organizer
      第71回高分子討論会
    • Data Source
      KAKENHI-PROJECT-22K19907
  • [Presentation] マイクロ流体デバイスによる脂質ナノ粒子の粒径制御とin vivo RNA送達2022

    • Author(s)
      佐藤悠介、奥田健斗、岩川和樹、佐々木宏輔、原島秀吉
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Multifunctional Envelope-type Nano Device: from Controlled Intracellular Trafficking to Clinical Application for Nanomedicine.2021

    • Author(s)
      Harashima H
    • Organizer
      FIP Host Madsen Medal 2021 Award Lecture.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] 次世代薬剤学を語ろう! 多機能性エンベロープ型ナノ構造体の創製と社会実装から見える次世代薬剤学2021

    • Author(s)
      原島秀吉
    • Organizer
      第36回日本薬剤学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Targeting mitochondria: innovation of mitochondrial drug delivery system (DDS) to mitochondrial medicine.2021

    • Author(s)
      Yamada Y, Harashima H.
    • Organizer
      Mitochondrial Medicine -Therapeutic Development.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] ミトコンドリア標的型 Drug Delivery System を基盤とした遺伝子治療戦略の検証2021

    • Author(s)
      山田 勇磨、原島秀吉
    • Organizer
      日本ゲノム編集学会第6回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] 低温下での脂質ナノ粒子の免疫細胞表面への結合が引き起こすトランスフェクション活性の消失2021

    • Author(s)
      中村孝司、山田小春、佐藤悠介、原島秀吉
    • Organizer
      第37回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Multifunctional Envelope-type Nano Device for gene delivery: Concept and Clinical Application for Nanomedicine.2020

    • Author(s)
      Harashima H
    • Organizer
      The 43rd Online KAST International Symposium “New Horizons of Nanobiological Therapeutics”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Nucleic Acid Drugs and Nanomedicine: Multifunctional Envelope-type Nano Device for Nanomedicine2020

    • Author(s)
      Hideyoshi Harashima, Yusuke Sato, Takashi Nakamura, Yuma Yamada
    • Organizer
      The 79 Annual Meeting of the Japanese Cancer Association.
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] 脂質ナノ粒子の特性がリンパ節送達とリンパ節内分布へ与える影響2020

    • Author(s)
      中村孝司、河合美典、佐藤悠介、真栄城正寿、渡慶次学、原島秀吉
    • Organizer
      日本薬剤学会 第35年会
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] A Mitochondrial DDS Towards An Innovative Therapy.2020

    • Author(s)
      Yamada Y, Harashima H.
    • Organizer
      2020 Annual Meeting & Exposition of the Controlled Release Society. “Rising Suns from Japanese Society of Drug Delivery System”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] BCG-CWS搭載脂質ナノ粒子の全身投与型がんアジュバントへの応用2020

    • Author(s)
      中村孝司、増田秀幸、野間洋輔、原島秀吉
    • Organizer
      第36回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] MITO-Porter, a cutting-edge mitochondrial DDS.2020

    • Author(s)
      Yamada Y, Harashima H.
    • Organizer
      Pharmaceutical Society of Korea 2020
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] TLR3 adjuvant-loaded liposome induce robust antitumor activity and reduces systemic inflammation following intravenous administration.2019

    • Author(s)
      Haloho S, Nakamura T, Harashima H
    • Organizer
      Liposome Research Days 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Liposomal delivery of TLR3 agonist induces robust antitumor activity without systemic inflammation following intravenous administration.2019

    • Author(s)
      Haloho S, Nakamura T, Harashima H.
    • Organizer
      The 48th Annual Scientific Meeting of the Australian and New Zealand Society for Immunology (ASI) 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Multifunctional Envelope-type Nano Device for Nucleic Acids/Gene Delivery2019

    • Author(s)
      Harashima Hideyoshi
    • Organizer
      Bio Incheon Global Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids2019

    • Author(s)
      Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H
    • Organizer
      Liposome Research Days 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] MITO-Porter, liposomal mitochondrial delivery system: Toward Mitochondrial Nanomedicine2019

    • Author(s)
      Yamada Y, Harashima H.
    • Organizer
      Liposome Research Days 2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Multifunctional Envelope-type Nano Device for Gene/Nucleic acids Delivery: Concept and Application to Nanomedicine2019

    • Author(s)
      Harashima Hideyoshi
    • Organizer
      15th US-Japan DDS Symposium.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] 多機能性エンベロープ型ナノ構造体の開発とナノ医療への展開:日本薬剤学会・日本薬学会合同シンポジウム 脂質・細胞製剤の新展開2019

    • Author(s)
      原島秀吉
    • Organizer
      日本薬剤学会第34回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] DNAマイクロアレイとin vivo siRNA送達システムの融合による新規2型糖尿病治療薬創出2013

    • Author(s)
      末光永理奈、林泰弘、梶本和昭、佐藤悠介、Afsana Akhter、櫻井遊、畠山浩人、兵藤守、加地範匡、馬場嘉信、原島秀吉
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋 (ウインクあいち)
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] An approach to mitochondrial genesilencing by the mitochondrial delivery of anti-sense RNA2013

    • Author(s)
      Y. Yamada, R. Furukawa, E. Kawamura, H. Harashima
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] ミトコンドリアを標的とした遺伝子発現制御の試み2013

    • Author(s)
      山田勇磨、 古川亮、原島秀吉.
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋 (ウインクあいち)
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] 膵β細胞株MIN6細胞を標的としたDDS, β-MENDの構築および核酸導入・機能発現の検証2013

    • Author(s)
      田端麻衣、山田勇磨、 安崎友香理、野村政壽、柴田篤志、佐々木茂樹、原島秀吉
    • Organizer
      日本薬学会北海道支部第140回例会
    • Place of Presentation
      札幌(札幌コンベンションセンター)
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] Improvement of mitochondrial targeting activity of MITO-Porter using functional peptides2013

    • Author(s)
      E. Kawamura, Y. Yamada, H. Harashima
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] A new approach for innovative nanomedicine of type 2 diabetes in combination with DNA microarray and in vivo siRNA delivery2013

    • Author(s)
      Suemitsu E, Hayashi Y, Kajimoto K, Sato Y, Akhter A, Sakurai Y, Hatakeyama H, Hyodo M, Harashima H,
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] Technologies in Gene Delivery for Nanomedicines2012

    • Author(s)
      Hideyoshi Harashima, Breakthrough
    • Organizer
      FIP Centennial, 2012
    • Place of Presentation
      Amsterdam, the Netherlands, Amsterdam RAI
    • Year and Date
      2012-10-08
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery2011

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      The 3rd Asian Biomaterials Congress
    • Place of Presentation
      BEXCO Busan (Korea)(招待講演)
    • Year and Date
      2011-09-19
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Controlled Intracellular trafficking of Non-viral Vectors2011

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      The 14th Annual Meeting of ASGCT Scientific Symposium Gene & Cell Therapy Around the Globe : A Showcase of Asia
    • Place of Presentation
      Washington State Convention & Trade Center (USA)(招待講演)
    • Year and Date
      2011-05-21
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] DDS製剤の臨床応用への課題、DDS製剤の臨床応用を目指して2011

    • Author(s)
      原島秀吉
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京)(招待講演)
    • Year and Date
      2011-05-31
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery : Concept and Application for Nanomedicine2011

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      Joint Meeting of the Austrian and German Pharmaceutical Sciences
    • Place of Presentation
      University of Innsbruck (Austria)(招待講演)
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] KALA-modified multi-layered nano particles as antigen gene carrier for MHC Class-I mediated antigen presentation in DNA vaccine approach2011

    • Author(s)
      Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yanashita A, Katoono R, Yui N, Harashima H
    • Organizer
      38th Annual Meeting & Exposition of the Controlled Release Society (CRS)
    • Place of Presentation
      Gaylord National Hotel and Convention Center (U.S.A.)
    • Year and Date
      2011-08-02
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery : Concept and Application for Nanomedicine2011

    • Author(s)
      Harashima H
    • Organizer
      Joint Meeting of the Austrian and German PharmaceuticalSciences
    • Place of Presentation
      University of Innsbruck (Austria)(招待講演)
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] 多機能性エンベロープ型ナノ構造体の創製とナノメディシンへの展開2011

    • Author(s)
      原島秀吉
    • Organizer
      第40回日本免疫学会学術集会関連分野セミナー
    • Place of Presentation
      幕張メッセ(千葉)(招待講演)
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery: Concept and Application for Nanomedicine2011

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      Joint Meeting of the Austrian and German Pharmaceutical Sciences
    • Place of Presentation
      Innsbruck, Austria, University of Innsbruck
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] バイオイメージングで可視化するナノメディシンの世界~多機能性エンベロープ型ナノ構造体が拓く遺伝子治療への道~2011

    • Author(s)
      原島秀吉
    • Organizer
      第20回日本バイオイメージング学会学術集会
    • Place of Presentation
      千歳科学技術大学(北海道)(招待講演)
    • Year and Date
      2011-09-01
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] 多機能性エンベロープ型ナノ構造体の創製とナノメディシンへの展開2011

    • Author(s)
      原島秀吉
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)(招待講演)
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Concept and Application of MEND2010

    • Author(s)
      Hideyoshi Harashima, Nanotechnology for In Vivo Gene Delivery
    • Organizer
      2010 FIP PSWC/AAPS Annual Meeting and Exposition, Short Course: Nanotechnology from A to Z: Achievement in Drug Delivery and Tissue Engineering
    • Place of Presentation
      New Orleans, U. S. A. Ernest N. Morial Convention Center
    • Year and Date
      2010-11-14
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] 多機能性エンベロープ型ナノ構造体による次世代医薬への新たな展開2010

    • Author(s)
      原島秀吉
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      徳島 招待講演
    • Year and Date
      2010-05-12
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] MENDで拓く創薬への道2010

    • Author(s)
      原島秀吉
    • Organizer
      金沢大学薬学シンポジウム2010創薬動態フォーラムin金沢
    • Place of Presentation
      金沢大学角間キャンパス金沢 招待講演
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] Multifunctional envelope-type nano device for non-viral gene delivery : Concept and application for nanomedicine2009

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      Asian Federation for Pharmaceutical Sciences 2009
    • Place of Presentation
      Centennial Hall Kyushu University, Fukuoka, Japan
    • Year and Date
      2009-10-17
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Multifunctional envelope-type nano device for non-viral gene delivery : Concept and application of programmed packaging2009

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      The 8^<th> Cerebral Vascular Biology 2009
    • Place of Presentation
      Sendai Excel Hotel Tokyu, Sendai, Japan
    • Year and Date
      2009-07-01
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Multifunctional envelope-type nano device for non-viral gene delivery: Concept and application for nanomedicine2009

    • Author(s)
      H. Harashima
    • Organizer
      Asian Federation for Pharmaceutical Sciences 2009
    • Place of Presentation
      Hakata, Japan(invited)
    • Year and Date
      2009-10-17
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Multifunctional envelope-type Nano Device for in vivo systemic delivery of siRNA2008

    • Author(s)
      H. Harashima
    • Organizer
      68th International Congres of FIP
    • Place of Presentation
      Basel, Switzerland(invited)
    • Year and Date
      2008-09-02
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Controlled Intracellular Trafficking of Non-viral Vector.2008

    • Author(s)
      H.Harashima
    • Organizer
      The 10th Annual Meeting of American Society of Gene Therapy: Education Session: Topical Review: Non-viral Vector esign and Efficacy.
    • Place of Presentation
      Seatle.Washington.USA
    • Year and Date
      2008-05-30
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Presentation] 血液サンプルを用いた2型糖尿病の遺伝子診断システムの開発2007

    • Author(s)
      林泰弘、飯田慎也、中谷明弘、澤田章弘、加地範匡、紙谷浩之、馬場嘉信、原島秀吉
    • Organizer
      日本薬剤学会第22年会
    • Place of Presentation
      大宮(大宮ソニックシティ)
    • Year and Date
      2007-05-21
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] 多機能性エンベロープ型ナノ構造体による人工遺伝子デリバリーシステムの創製2007

    • Author(s)
      原島秀吉
    • Organizer
      第23会日本DDS学会
    • Place of Presentation
      熊本
    • Year and Date
      2007-06-15
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Presentation] Multifunctional envelope type nano device for non-viral gene delivery: Concept and application of Programmed Packaging2007

    • Author(s)
      H.Harashima
    • Organizer
      13th International Symposium on Recent Advances in Drug Delivery Systems
    • Place of Presentation
      Salt Lake City.Utah.USA.
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Presentation] 血管内皮細胞標的化ペプチド搭載リポソームの細胞内取り込み機構の解析2007

    • Author(s)
      秋田英万、ディッキー・ムダキュル、タン・エルダル、原島秀吉
    • Organizer
      日本薬剤学会第22年会
    • Place of Presentation
      大宮(大宮ソニックシティ)
    • Year and Date
      2007-05-21
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] 多機能性エンベロープ型人工遺伝子デリバリーシステムの創製2007

    • Author(s)
      原島秀吉
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-29
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Presentation] A Multi-functional envelope type nano device as an anti-tumor gene delivery system2007

    • Author(s)
      原島 秀吉
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-18015004
  • [Presentation] Multifunctional envelope type nano device for non-viral gene delivery: Concept and application of Programmed Packaging2007

    • Author(s)
      H. Harashima
    • Organizer
      13th International Symposium on Recent Advances in Drug Delivery Systems
    • Place of Presentation
      Salt Lake City, Utah, USA.(invited)
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Cellular uptake mechanism and intracellular trafficking study of the novel C152-peptide-modified liposomes(C152-Lip)2007

    • Author(s)
      ディッキームダキュル、秋田英万、タンエルダル、原島秀吉
    • Organizer
      第23回日本DDS学会
    • Place of Presentation
      熊本(熊本日航ホテル)
    • Year and Date
      2007-06-15
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] 多機能性エンベロープ型ナノ構造体による人工遺伝子デリバリーシステムの創製2007

    • Author(s)
      原島秀吉
    • Organizer
      第23回日本DDS学会永井賞受賞講演
    • Place of Presentation
      熊本(invited)
    • Year and Date
      2007-06-15
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] 多機能性エンベロープ型人工遺伝子デリバリーシステムの創製2007

    • Author(s)
      原島秀吉
    • Organizer
      日本薬学会第127年会(学術振興賞受賞講演)
    • Place of Presentation
      富山(invited)
    • Year and Date
      2007-03-29
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Controlled Intracellular Trafficking of Non-viral Vector2007

    • Author(s)
      H. Harashima
    • Organizer
      The 10th Annual Meeing of American Society of Gene Therapy: Education Session: Topical Review: Non-viral Vector esign and Efficacy
    • Place of Presentation
      Seatle, Washington, USA
    • Year and Date
      2007-05-30
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Breakthrough Technologies in Gene Delivery for Nanomedicines

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      FIP Centennial, 2012
    • Place of Presentation
      Amsterdam RAI, Amsterdam, The Netherland
    • Invited
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Multifunctional Envelope-type Nano Device as gene delivery system for Nanomedicine

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      The 10th France - Japan DDS Symposium
    • Place of Presentation
      Grande Hotel de Bordeaux, Bordeaux, France
    • Invited
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      IBS 2012 15th International Biotechnology Symposium and Exhibition
    • Place of Presentation
      EXCO Daegu, Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Breakthrough Technologies in Gene Delivery for Nanomedicines

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      FIP Centennial, 2012
    • Place of Presentation
      Amsterdam RAI (The Netherlands)
    • Invited
    • Data Source
      KAKENHI-PROJECT-22659006
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