hasegawa masato 長谷川成人

… Alternative Names

HASEGAWA Masato 長谷川成人

長谷川成人ハセガワマサト

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Researcher Number	10251232
Other IDs
Affiliation (Current)	2024: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 分野長
Affiliation (based on the past Project Information) *help	2022 – 2024: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 分野長 2012 – 2023: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 分野長 2013 – 2016: 公益財団法人東京都医学総合研究所, 認知症高次脳機能研究分野, 分野長 2015: 東京都医学総合研究所, 認知症高次脳機能研究分野, 分野長 2011 – 2012: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能分野, 参事研究員 … More 2011: 公益財団法人東京都医学総合研究所, 認知症高次脳機能分野長, 参事研究員 2011: 財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 参事研究員 2008 – 2009: Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 副参事研究員 2007 – 2009: Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 副参事研究員 2008: 東京都精神医学総合研究所, 分子神経生物学研究チーム, 部長 2007: 東京都精神医学総合研究所, 副参研究員 2005 – 2006: Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, Head of department, 東京都精神医学総合研究所, 副参事研究員 2004: 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 副参事研究員 2003: (財)東京都医学研究機構, 東京都精神医学総合研究所, 副参事研究員 2001 – 2002: 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 副参事研究員 2001: 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 研究員 2000: 東京大学, 大学院・薬学系研究科, 講師 1994: 東京大学, 医学部(医), 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Biological Sciences / Nerve anatomy/Neuropathology / Medium-sized Section 51:Brain sciences and related fields / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 49010:Pathological biochemistry-related / Neurology … More / Basic Section 52010:General internal medicine-related / Basic Section 52020:Neurology-related / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Biological Sciences / Psychiatric science / Basic veterinary science/Basic zootechnical science / Neurology Less
Keywords	Principal Investigator タウ / αシヌクレイン / TDP-43 / リン酸化 / 伝播 / 神経変性疾患 / プリオン / アミロイド / 線維 / 脳神経疾患 … More / ユビキチン化 / 微小管 / FTDP-17 / ユビキチン / 封入体 / ピック病 / Cdk5 / アルツハイマー病 / APP / C9ORF72 / 神経変性 / 断片化 / 凝集阻害剤 / Aβ / アミロイド線維 / アミロイドβ / 進行性核上性麻痺 / 線維形成 / α-synuclein / スプライシング / 蛋白質 / プロテオーム / 老化 / 痴呆 / PHF / DLB / MSA / 不活性化 / Lewy body / Parkinson's disease / casein kinase 2 / filaments / ubiquitination / phosphorylation / alpha-synuclein / 多系統萎縮症 / レヴィー小体型痴呆 / レヴィー小体 / レビー小体 / パーキンソン病 / カゼインキナーゼ2 / Neurodegenrative disease / splicing / Phosphorylation / Tau / p35 / 前頭側頭型痴呆 / タウオパチー / CdKS / CJD / プログラニュリン / 前頭側頭葉変性症 / 感染 / シヌクレイン / 異常蛋白 / 変性疾患 / 構造変化 / 線維化 / FTLD / パーキンソン / アルツハイマー / 進行性核上性麻痺(PSP) / 皮質基底核変性症(CBD) / タンパク質 / 細胞死 / 神経細胞死 / プロリン指向性キナーゼ … More Except Principal Investigator 認知症 / パーキンソン病 / アルツハイマー病 / アグリソーム / リン酸化 / TDP-43 / 加齢 / 糖尿病 / シヌクレイン / 細胞死 / 活性酸素 / ストレス顆粒 / USP10 / aggresome / ALS / αシヌクレイン / 老化 / 神経変性疾患 / 筋萎縮性側索硬化症 / α-Synuclein / Lewy小体型痴呆症 / p62 / Keap1 / Nrf2 / 神経毒性 / オリゴマー / 遺伝子発現 / 肥満 / G3BP2 / G3BP1 / ユビキチン / ｐ６２ / NRF2 / ドーパミン / 凝集体 / プリオン / プロフィリン１ / prion / seeding / LC3 / mutation / Profilin1 / タウ / 異常蛋白蓄積 / 伝播 / 異常蓄積蛋白 / 病理 / neuronal death / ubiquitination / phosphorylation / Lewy body / a-synuclein / Parkinson's disease / Lewy小体痴呆症 / 脳神経疾患 / 神経科学 / 神経細胞化 / ユビキチン化 / Lewy小体 / α-シヌクレイン / 変性 / 蓄積 / 蛋白質 / 神経新生 / 神経変性 / 成長因子 / 脳・神経 / ウイルスベクター / 脳分子プロファイル / モデル動物 / 脳画像データベース / ブレインバンク / 技術開発支援 / 研究リソース支援 / 若手研究者育成支援 / 技術開発 / 研究リソース / 研究集会 / 研究支援 / 脳科学 / 人格変化 / 運動障害 / 封入体 / グアム島 / パーキンソン症候群 / タウオパチー / タウ蛋白 / 酸化ストレス / アルツハイマー神経原線維変化 / 遺伝子 / パーキンソン認知症複合 / 紀伊半島 / 髄液診断 / 生化学マーカー Less

全身の代謝および老化からみたアルツハイマー病の解析
- Principal Investigator
  
  里直行
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  National Center for Geriatrics and Gerontology
疾患特徴的タウ病理の形成と伝達機構Principal Investigator
- Principal Investigator
  
  長谷川成人
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
神経病原性蛋白質オリゴマーの神経毒性を抑制する分子メカニズム
- Principal Investigator
  
  藤井雅寛
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Niigata University
糖尿病や加齢が認知症の後天的危険因子である分子メカニズムの多角的解明
- Principal Investigator
  
  里直行
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  National Center for Geriatrics and Gerontology
Mechanism of inactivation of neuropathogenic protein toxicity by aggresomes
- Principal Investigator
  
  FUJII MASAHIRO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Niigata University
Propagation of prion-like proteins and cellular responsesPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Masato
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
The mechanism of cytotoxicity from ALS-linked Profilin 1 mutations
- Principal Investigator
  
  TANAKA Yoshinori
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Molecular bases of pathogenic proteins and mechanisms of the propagationPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Masato
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
細胞内異常タンパク質の蓄積機構Principal Investigator
- Principal Investigator
  
  長谷川成人
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Pathological study of abnormal protein accumulation and its propagation in the brain of patients with dementia
- Principal Investigator
  
  AKIYAMA Haruhiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
細胞内異常タンパク質と回路選択的神経変性Principal Investigator
- Principal Investigator
  
  長谷川成人
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Physiological actions and pathological relevance of growth factors in the brain
- Principal Investigator
  
  NISHIHARA Masugi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Molecular mechanisms of pathological protein propagation and its regulationPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Masato
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Pathological and biochemical study of dementia as a combined protein accumulation disease
- Principal Investigator
  
  ARAI Tetsuaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  University of Tsukuba
Comprehensive Brain Science Network
- Principal Investigator
  
  Kimura Minoru
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Center for Novel Science Initatives, National Institutes of Natural Sciences
神経変性疾患における異常蛋白質蓄積機構の解明Principal Investigator
- Principal Investigator
  
  長谷川成人
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Molecular biological study on the cause and pathogenesis of amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan
- Principal Investigator
  
  KUZUHARA Shigeki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry
  Mie University
Analyses of the nuclear protein that aggregates in brains of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration
- Principal Investigator
  
  ARAI Tetsuaki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
タウ、αシヌクレイン、アミロイドβ蛋白を介した神経変性の解明と治療に関する研究Principal Investigator
- Principal Investigator
  
  長谷川成人
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Molecular mechanisms of conformational changes of proteins and neurodegeneration in neurodegenerative diseases.Principal Investigator
- Principal Investigator
  
  HASEGAWA Masato
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
タウ、aシヌクレインを介した神経変性の解明と治療に関する研究Principal Investigator
- Principal Investigator
  
  長谷川成人
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
神経変性疾患におけるタウ蛋白の蓄積機構Principal Investigator
- Principal Investigator
  
  長谷川成人
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
神経変性疾患におけるタウ蛋白の蓄積機構Principal Investigator
- Principal Investigator
  
  長谷川成人
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Identification of protein kinase(s) involved in abnormal phosphorylation of alpha-synucleinPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Masato
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
神経変性疾患におけるタウ蛋白の蓄積機構Principal Investigator
- Principal Investigator
  
  長谷川成人
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
神経変性疾患における異常リン酸化タウの蓄積機構の解明Principal Investigator
- Principal Investigator
  
  長谷川成人
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
脳脊髄液中α-synuclein微量測定による神経変性疾患診断方法開発の試み
- Principal Investigator
  
  IWATSUBO Takeshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
Title "Molecular Pathogenesis of Parkinson's Disease"
- Principal Investigator
  
  IWATSUBO Takeshi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tokyo
Biochemical characterization of tau in tauopaty brainsPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Masato
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
  The University of Tokyo
アルツハイマー病脳に蓄積するPHFタウの胎児型、非胎児型異常リン酸化部位の同定Principal Investigator
- Principal Investigator
  
  長谷川成人
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo

[Book] 思春期学2015
- Author(s)
  笠井清登、長谷川眞理子、藤井直敬、福田正人
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-221S0003
[Book] 細胞内異常タンパク質の伝播の可能性2013
- Author(s)
  長谷川成人
- Publisher
  Dementia Japan
- Data Source
  KAKENHI-PROJECT-23240050
[Book] 細胞内異常タンパク質凝集体の細胞間伝播 : 神経変性疾患の病態進行に関する新たなメカニズム2013
- Author(s)
  野中隆, 長谷川成人
- Publisher
  基礎老化研究
- Data Source
  KAKENHI-PROJECT-23240050
[Book] Braak 仮説をαシヌクレインの細胞間伝播で説明できるか?2013
- Author(s)
  長谷川成人
- Publisher
  Frontiers in Parkinson's Disease
- Data Source
  KAKENHI-PROJECT-23240050
[Book] 脳内に蓄積したTDP-43 凝集体のプリオン様性質2013
- Author(s)
  野中隆, 長谷川成人
- Publisher
  細胞工学
- Data Source
  KAKENHI-PROJECT-23240050
[Book] seriesモデル動物利用マニュアル2011
- Author(s)
  野中隆, 新井哲明, 長谷川成人
- Publisher
  LIFE-SCIENCE INFORMATION CENTER
- Data Source
  KAKENHI-PROJECT-23591694
[Book] 筋萎縮性側索硬化症(ALS)マウス、seriesモデル動物利用マニュアル、疾患モデルの作製と利用、脳・神経疾患2011
- Author(s)
  野中隆, 新井哲明, 長谷川成人
- Publisher
  LIFE-SCIENCE INFORMATION CENTER
- Data Source
  KAKENHI-PROJECT-23591694
[Book] 神経原線維変化: 老年期認知症ナビゲーター( 平井俊策監修)2006
- Author(s)
  長谷川成人
- Publisher
  東京 : メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-18300117
[Book] タウ:老年期認知症ナビゲーター(平井俊策監修)2006
- Author(s)
  長谷川成人
- Publisher
  東京 : メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy2018
- Author(s)
  Kaji Seiji、Maki Takakuni、Kinoshita Hisanori、Uemura Norihito、Ayaki Takashi、Kawamoto Yasuhiro、Furuta Takahiro、Urushitani Makoto、Hasegawa Masato、Kinoshita Yusuke、Ono Yuichi、Mao Xiaobo、Quach Tran H.、Iwai Kazuhiro、Dawson Valina L.、Dawson Ted M.、Takahashi Ryosuke
- Journal Title
  
  Stem Cell Rep
  
  Volume: 10 Issue: 2 Pages: 356-365
- DOI
  10.1016/j.stemcr.2017.12.001
- NAID
  120006414715
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05698, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-15H04266, KAKENHI-PROJECT-16K18383
[Journal Article] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.2018
- Author(s)
  Tuerde, D., Kimura, T., Miyasaka, T., Furusawa, K., Shimozawa, A., Hasegawa, M., Ando, A., Hisanaga, S.
- Journal Title
  
  J. Biol, Chem.
  
  Volume: 293 Issue: 5 Pages: 1781-1793
- DOI
  10.1074/jbc.m117.798918
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-17K07113, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-17J06398
[Journal Article] The effect of truncation on prion-like properties of α-synuclein.2018
- Author(s)
  Terada T, Suzuki G, Nonaka T, Kametani F, Tamaoka A, and Hasegawa M.
- Journal Title
  
  J Biol Chem
  
  Volume: 293 Issue: 36 Pages: 13910-13920
- DOI
  10.1074/jbc.ra118.001862
- NAID
  120007133755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-16K09681, KAKENHI-PROJECT-16K21650
[Journal Article] otent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.2018
- Author(s)
  Tarutani A, Arai T, Murayama S, Hisanaga SI, Hasegawa M
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 6 Issue: 1 Pages: 29-29
- DOI
  10.1186/s40478-018-0532-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-18K18443, KAKENHI-PROJECT-18K15359, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K07060
[Journal Article] Pathological and immunoblot analysis of phosphorylated TDP-43 in sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration.2018
- Author(s)
  Uchino A, Ogino M, Takahashi-Fujigasaki J, Oonuma S, Kanazawa N, Kajita S. Ichinoo M, Hasegawa M, Nishiyama K, Murayama S.
- Journal Title
  
  Neuropathology
  
  Volume: 38 Issue: 2 Pages: 171-178
- DOI
  10.1111/neup.12430
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06277, KAKENHI-PLANNED-26117005
[Journal Article] N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APPSw,Ind Mice2018
- Author(s)
  Franco Rafael、Aguinaga David、Reyes Irene、Canela Enric I.、Lillo Jaume、Tarutani Airi、Hasegawa Masato、del Ser-Badia Anna、del Rio Jose A.、Kreutz Michael R.、Saura Carlos A.、Navarro Gemma
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 11 Pages: 273-273
- DOI
  10.3389/fnmol.2018.00273
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15359, KAKENHI-PLANNED-26117005
[Journal Article] Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice2018
- Author(s)
  Hosokawa M, Tanaka Y, Arai T, Kondo H, Akiyama H, Hasegawa M
- Journal Title
  
  Exp. Anim.
  
  Volume: 67 Issue: 1 Pages: 63-70
- DOI
  10.1538/expanim.17-0060
- NAID
  130006339997
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09850, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] C9ORF72 dipeptide repeat poly-GA inclusions promote: intracellular aggregation of phosphorylated TDP-432018
- Author(s)
  Nonaka T, Masuda-Suzukake M, Hosokawa M, Shimozawa A, Hirai S, Okado, H., Hasegawa, M.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 27 Issue: 15 Pages: 2658-2670
- DOI
  10.1093/hmg/ddy174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117005
[Journal Article] Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome2018
- Author(s)
  Yabe I, Yaguchi H, Kato Y, Miki Y, Takahashi H, Tanikawa S, Shirai S, Takahashi I, Kimura M, Hama Y, Matsushima M, Fujioka S, Kano T, Watanabe M, Nakagawa S, Kunieda Y, Ikeda Y, Hasegawa M, Nishihara H, Ohtsuka T, Tanaka S, Tsuboi Y, Hatakeyama S, Wakabayashi K, Sasaki H
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 819-819
- DOI
  10.1038/s41598-018-19198-0
- NAID
  120006377499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09663, KAKENHI-PROJECT-16K09665, KAKENHI-PROJECT-17K19506, KAKENHI-PUBLICLY-17H05560, KAKENHI-PUBLICLY-17H05741, KAKENHI-PUBLICLY-17H05989, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-15H04272, KAKENHI-PROJECT-15H04701, KAKENHI-PROJECT-16H06221, KAKENHI-PROJECT-18H02378, KAKENHI-PROJECT-17K19578
[Journal Article] Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation2017
- Author(s)
  Hosokawa M, Arai T. Kondo H. Serrano GE. Beach TG. Robinson AC. Mann DM. Akiyama H. Haesgawa M
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 1513-1513
- DOI
  10.1038/s41598-017-01587-6
- NAID
  120007129118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09850, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Propagation of pathological α-synuclein in marmoset brain2017
- Author(s)
  Aki Shimozawa, Maiko Ono, Daisuke Takahara, Airi Tarutani, Sei Imura, Masami Masuda-Suzukake, Makoto Higuchi, Kazuhiko Yanai, Shin-ichi Hisanaga, Masato Hasegawa
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 5 Issue: 1 Pages: 12-14
- DOI
  10.1186/s40478-017-0413-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.2017
- Author(s)
  Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Pages: 969-988
- DOI
  10.1093/hmg/ddx011
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-16K21650, KAKENHI-PROJECT-15K09850, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Pick's disease with neuronal four-repeat tau accumulation in the basal ganglia, brain stem nuclei and cerebellum.2017
- Author(s)
  Ikeda C, Yokota O, Miki T, Takenoshita S, Ishizu H, Mori Y, Yamazaki K, Ozaki Y, Ueno SI, Ishihara T, Hasegawa M, Terada S, Yamada N.
- Journal Title
  
  Neuropathology
  
  Volume: 37 Issue: 6 Pages: 544-559
- DOI
  10.1111/neup.12394
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15K09867
[Journal Article] Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation2017
- Author(s)
  Okada Takuya、Keino-Masu Kazuko、Nagamine Satoshi、Kametani Fuyuki、Ohto Tatsuyuki、Hasegawa Masato、van Kuppevelt Toin H.、Kunita Satoshi、Takahashi Satoru、Masu Masayuki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 13847-13847
- DOI
  10.1038/s41598-017-14185-3
- NAID
  120007134746
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K06987, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Wild-type monomeric α-synuclein can impair vesicle endocytosis and synaptic fidelity via tubulin polymerization at the calyx of Held.2017
- Author(s)
  Eguchi K, Taoufiq Z, Thorn-Seshold O, Trauner D, Hasegawa M, Takahashi T
- Journal Title
  
  J Neurosci
  
  Volume: 37 Issue: 25 Pages: 6043-6052
- DOI
  10.1523/jneurosci.0179-17.2017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] TDP-43 stabilises the processing intermediates of mitochondrial transcripts.2017
- Author(s)
  Izumikawa K, Nobe Y, Yoshikawa H, Ishikawa H, Miura Y, Nakayama H, Nonaka T, Hasegawa M, Egawa N, Inoue H, Nishikawa K, Yamano K, Simpson RJ, Taoka M, Yamauchi Y, Isobe T, Takahashi N
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 7709-7709
- DOI
  10.1038/s41598-017-06953-y
- NAID
  120006364102
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-16K18489
[Journal Article] Frontotemporal dementia with trans-activation response DNA-binding protein 13 presenting with cartatonic syndrome.2017
- Author(s)
  Watanabe R, Kawakami I, Onaya M, Higashi S, Arai N, Akiyama H, Hasegawa M, Arai T
- Journal Title
  
  Neuropathology
  
  Volume: 印刷中 Issue: 3 Pages: 281-287
- DOI
  10.1111/neup.12442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09822, KAKENHI-PLANNED-26117005
[Journal Article] Unusual tau pathology of the cerebellum in patients with amyotrophic lateral sclerosis/parkinsonism-dementia complex from the kii peninsula, Japan.2017
- Author(s)
  Morimoto S, Hatsuta H, Kokubo Y, Nakano Y, Hasegawa M, Yoneda M, Hirokawa Y, Kuzuhara S, Shiraishi T, Murayama S.
- Journal Title
  
  Brain Pathol.
  
  Volume: - Issue: 2 Pages: 287-291
- DOI
  10.1111/bpa.12500
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25257507, KAKENHI-PROJECT-15J03921, KAKENHI-PROJECT-15K09364, KAKENHI-PROJECT-25305030, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239
[Journal Article] Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease2017
- Author(s)
  Mano Tatsuo、Nagata Kenichi、Nonaka Takashi、Tarutani Airi、Imamura Tomohiro、Hashimoto Tadafumi、Bannai Taro、Koshi-Mano Kagari、Tsuchida Takeyuki、Ohtomo Ryo、Takahashi-Fujigasaki Junko、Yamashita Satoshi、Ohyagi Yasumasa、Yamasaki Ryo、Tsuji Shoji、Tamaoka Akira、et al.
- Journal Title
  
  Proc Natl Acad Sci U.S.A.
  
  Volume: 114 Issue: 45
- DOI
  10.1073/pnas.1707151114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09664, KAKENHI-PROJECT-17K16113, KAKENHI-PUBLICLY-17H05687, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-16H05319, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
[Journal Article] Neurodegeneration in Frontotemporal Lobar Degeneration and Motor Neurone Disease associated with expansions in C9orf72 is not associated with aggregated forms of dipeptide repeat proteins.2016
- Author(s)
  Davidson Y, Robinson AC, Troakes C, Smith B, Al-Saraj S, Shaw C, Rollinson S, Masuda-Suzukake M, Suzuki G, Nonaka T, Pickering-Brown S, Snowden JS, Hasegawa M, Mann DMA.
- Journal Title
  
  Neuropathol Appl Neurobiol.
  
  Volume: 42 Issue: 3 Pages: 242-254
- DOI
  10.1111/nan.12292
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111730, KAKENHI-PROJECT-15H02356
[Journal Article] Interplay between TDP-43 and docosahexaenoic acid-treated processes in amyotrophic lateral sclerosis.2016
- Author(s)
  Cacabelosa D, Ayalaa V, Belen Granado-Serranoa A, Jove M, Torresa P, Boadaa J, Cabre R, Ramirez-Nuneza O, Gonzaloa H, Soler-Canterob A, Carlos Enrique Serranoa J, Josep Bellmunta M, Paz Romerob M, Jose Motilvab M, Nonaka T, Hasegawa M, Ferrerd I, Pamplonaa R, and Portero-Otin M.
- Journal Title
  
  Neurobiol. Dis.
  
  Volume: 88 Pages: 148-160
- DOI
  10.1016/j.nbd.2016.01.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.2016
- Author(s)
  Kim C, Lv G, Lee JS, Jung BC, Masuda-Suzukake M, Hong CS, Valera E, Lee HJ, Paik SR, Hasegawa M, Masliah E, Eliezer D, Lee SJ.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 30891-30891
- DOI
  10.1038/srep30891
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.2016
- Author(s)
  Tarutani A, Suzuki G, Shimozawa A, Nonaka T, Akiyama H, Hisanaga S, and Hasegawa M.
- Journal Title
  
  J. Biol. Chem., J. Biol. Chem.
  
  Volume: 291 Issue: 36 Pages: 18675-18688
- DOI
  10.1074/jbc.m116.734707
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K21650, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.2016
- Author(s)
  Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Issue: 17 Pages: 8896-907
- DOI
  10.1074/jbc.m115.713552
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02356, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K21650
[Journal Article] .Cellebeller neuronal loss in ALS cases with ATXN2 intermediate repeat expansions.2016
- Author(s)
  Tan R, Kril J, McGinley C, Hassani M, Suzukake M, Hasegawa M, Remika M, Kiernan M, Halliday G
- Journal Title
  
  Ann Neurol
  
  Volume: 79 Issue: 2 Pages: 295-305
- DOI
  10.1002/ana.24565
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02356
[Journal Article] The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method2016
- Author(s)
  Kimura T, Hatsuta H, Masuda-Suzukake M, Hosokawa M, Ishiguro K, Akiyama H, Murayama S, Hasegawa M, Hisanaga S
- Journal Title
  
  American Journal of Pathology
  
  Volume: 186 Issue: 2 Pages: 398-409
- DOI
  10.1016/j.ajpath.2015.10.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09850, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25290024, KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-16H06277
[Journal Article] Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.2016
- Author(s)
  Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
- Journal Title
  
  The journal of Biological Chemistry
  
  Volume: 291 Issue: 11 Pages: 5473-83
- DOI
  10.1074/jbc.m115.695379
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-221S0003, KAKENHI-ORGANIZER-25115001, KAKENHI-PLANNED-25115006, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-25250010, KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-26251004, KAKENHI-PROJECT-26290016, KAKENHI-PROJECT-16K14569, KAKENHI-PROJECT-16K14675
[Journal Article] Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.2016
- Author(s)
  Kametani, F.;Obi, T.;Shishido, T.;Akatsu, H.;Murayama, S.;Saito, Y.;Yoshida, M.;Hasegawa, M.
- Journal Title
  
  Sci Rep
  
  Volume: － Issue: 1 Pages: 23281-23281
- DOI
  10.1038/srep23281
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-25461777, KAKENHI-PROJECT-16H06277
[Journal Article] Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.2016
- Author(s)
  Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, Niizato K, Oshima K, Higashi S, Katsuse O, Hosokawa M, Hasegawa M, Akiyama H.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 4 Issue: 1 Pages: 36-36
- DOI
  10.1186/s40478-016-0304-9
- NAID
  120007135517
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09822, KAKENHI-PROJECT-15K09850, KAKENHI-PUBLICLY-26111730, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-26461733, KAKENHI-PROJECT-15K19757, KAKENHI-PROJECT-26461752
[Journal Article] α-Synuclein fibrils exhibit gain-of-toxic-function, promoting tau aggregation and inhibiting microtubule assembly.2016
- Author(s)
  Oikawa T, Nonaka T, Hisanaga S, Hasegawa M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 291 Issue: 29 Pages: 15046-15056
- DOI
  10.1074/jbc.m116.736355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.2016
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 25 Issue: 7 Pages: 1420-33
- DOI
  10.1093/hmg/ddw024
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-221S0003, KAKENHI-PUBLICLY-26111730, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-16K21650
[Journal Article] Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau.2016
- Author(s)
  Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DM, Iwatsubo T, Hasegawa M.
- Journal Title
  
  Acta Neuropathol.
  
  Volume: 131(2) Issue: 2 Pages: 267-280
- DOI
  10.1007/s00401-015-1503-3
- NAID
  120007128537
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461733, KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-16H06277
[Journal Article] Profilin 1 mutants form aggregates that induce accumulation of prion-like TDP-43.2016
- Author(s)
  Tanaka Y, Hasegawa M
- Journal Title
  
  Prion
  
  Volume: 10 Issue: 4 Pages: 283-289
- DOI
  10.1080/19336896.2016.1207033
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-15K18370
[Journal Article] α-Synuclein: Experimental Pathology.2016
- Author(s)
  Hasegawa M, Nonaka T, Masuda-Suzukake M.
- Journal Title
  
  Cold Spring Harb Perspect Med.
  
  Volume: 6 Issue: 9 Pages: a024273-a024273
- DOI
  10.1101/cshperspect.a024273
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties.2015
- Author(s)
  Matsumoto, S.E.;Motoi, Y.;Ishiguro, K.;Tabira, T.;Kametani, F.;Hasegawa, M.;Hattori, N.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 24 Issue: 22 Pages: 6403-6416
- DOI
  10.1093/hmg/ddv351
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch2015
- Author(s)
  Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M
- Journal Title
  
  Nat Med
  
  Volume: 21 Issue: 8 Pages: 927-931
- DOI
  10.1038/nm.3912
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15203, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-23229008, KAKENHI-PROJECT-26893182
[Journal Article] Accumulation of dipeptide repeat proteins predates that of TDP-43 in Frontotemporal Lobar Degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene2015
- Author(s)
  2.Baborie A, Griffiths TD, Jaros E, Perry R, McKeith IG, Burn DJ, Masuda-Suzukake M, Hasegawa M, Rollinson S, Pickering-Brown S, Robinson AC, Davidson YS, Mann DM
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume: in press Issue: 5 Pages: 601-12
- DOI
  10.1111/nan.12178
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005
[Journal Article] Progranulin reduction is associated with tau phosphorylation in P301L tau transgenic mice2015
- Author(s)
  Hosokawa M, Arai T, Masuda-Suzukake M, Kondo H, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Journal Title
  
  J Neuropahol Exp Neurol
  
  Volume: 74 Issue: 2 Pages: 158-165
- DOI
  10.1097/nen.0000000000000158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26461733
[Journal Article] An autopsy case of familial amyotrophic lateral sclerosis with a TARDBP Q343R mutation.2015
- Author(s)
  Okamoto K, Fujita Y, Hoshino E, Tamura Y, Fukuda T, Hasegawa M, Takatama M.
- Journal Title
  
  Neuropathology
  
  Volume: 35 Issue: 5 Pages: 462-8
- DOI
  10.1111/neup.12209
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117005
[Journal Article] Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau.2015
- Author(s)
  Takahashi M, Miyata H, Kametani F, Nonaka T, Akiyama H, Hisanaga SI, Hasegawa M.
- Journal Title
  
  Acta Neuropathol.
  
  Volume: 129 Issue: 6 Pages: 895-907
- DOI
  10.1007/s00401-015-1415-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25290024
[Journal Article] Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.2015
- Author(s)
  Nishizawa D et al.
- Journal Title
  
  Mol Brain.
  
  Volume: 8 Issue: 1 Pages: 50-50
- DOI
  10.1186/s13041-015-0142-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K12768, KAKENHI-PROJECT-26860360, KAKENHI-PUBLICLY-15H01303, KAKENHI-PUBLICLY-15H01425, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-25253074, KAKENHI-PROJECT-15H03122, KAKENHI-PROJECT-26670481, KAKENHI-PROJECT-26670541, KAKENHI-PROJECT-25293250, KAKENHI-PROJECT-26293347, KAKENHI-PROJECT-25242062
[Journal Article] Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.2015
- Author(s)
  Hasegawa, M.;Hara-Miyauchi, C.;Ohta, H.;Sakimura, K.;Okano, H.;Okano, H. J.
- Journal Title
  
  Neurosci Res
  
  Volume: － Pages: 12-22
- DOI
  10.1016/j.neures.2015.11.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PUBLICLY-26111723, KAKENHI-PROJECT-26640007, KAKENHI-PLANNED-26117007
[Journal Article] Differential diagnosis of amyotrophic lateral sclerosis from Guillain–Barre´ syndrome by quantitative determination of TDP-43 in cerebrospinal fluid2014
- Author(s)
  Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda-Suzukake M, Tamaoka A, Hasegawa M, Akiyama H
- Journal Title
  
  Int J Neurosci
  
  Volume: 124 Pages: 344-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Tau accumulation in the nucleus accumbens in tangle-predominant dementia2014
- Author(s)
  Kawakami I, Hasegawa M, Arai T, Ikeda K, Oshima K, Niizato K, Aoki N, Katsuse O, Higashi S, Hosokawa M, Hirayasu Y, Akiyama H
- Journal Title
  
  Acta Neuropathol
  
  Volume: Commun 2 Issue: 1 Pages: 40-40
- DOI
  10.1186/2051-5960-2-40
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26461733
[Journal Article] Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.2014
- Author(s)
  Yamashita S, Sakashita N, Yamashita T, Tawara N, Tasaki M, Kawakami K, Komohara Y, Fujiwara Y, Kamikawa M, Nakagawa T, Hirano T, Maeda Y, Hasegawa M, Takeya M, Ando Y
- Journal Title
  
  Journal of Neurology
  
  Volume: 261 Issue: 11 Pages: 2209-2217
- DOI
  10.1007/s00415-014-7491-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590448, KAKENHI-PROJECT-24591269, KAKENHI-PROJECT-25860501, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670190, KAKENHI-PROJECT-26860372
[Journal Article] Distinct pathways leading to TDP-43-induced cellular dysfunctions.2014
- Author(s)
  Yamashita M, Nonaka T, Hirai S, Miwa A, Okado H, Arai T, Hosokawa M, Akiyama H, Hasegawa M.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 23 Issue: 16 Pages: 4345-56
- DOI
  10.1093/hmg/ddu152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PROJECT-24700370, KAKENHI-PUBLICLY-25123726, KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26461733
[Journal Article] 3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease.2014
- Author(s)
  Hasegawa, M., S. Watanabe, H. Kondo, H. Akiyama, D. M. Mann, Y. Saito and S. Murayama
- Journal Title
  
  Acta Neuropathol
  
  Volume: 127 Issue: 2 Pages: 303-305
- DOI
  10.1007/s00401-013-1191-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-24300133, KAKENHI-PROJECT-24500429, KAKENHI-PUBLICLY-25110738
[Journal Article] Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-22014
- Author(s)
  Asada, A., Yamazaki, R., Kino, Y., Saito, T., Kimura, T., Miyake, M., Hasegawa, M., Nukina, N. & Hisanaga, S.
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 563 Pages: 112-117
- DOI
  10.1016/j.neulet.2014.01.046
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PROJECT-23791007, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25290024, KAKENHI-PROJECT-25461299, KAKENHI-PLANNED-26117005
[Journal Article] 3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease2014
- Author(s)
  Hasegawa M, Watanabe S, Kondo H, Akiyama H, Mann DMA, Saito Y and Murayama S
- Journal Title
  
  Acta Neuropathol
  
  Volume: 127(2) Pages: 303-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-beta precursor.2014
- Author(s)
  Hasegawa, H., L. Liu, I. Tooyama, S. Murayama and M. Nishimura
- Journal Title
  
  Nat Commun
  
  Volume: 5 Issue: 1 Pages: 3917-3917
- DOI
  10.1038/ncomms4917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23300155, KAKENHI-PROJECT-23500445, KAKENHI-PROJECT-23590359, KAKENHI-PROJECT-26430070
[Journal Article] Differential diagnosis of amyotrophic lateral sclerosis from Guillain–Barre´ syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.2014
- Author(s)
  Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda-Suzukake M, Tamaoka A, Hasegawa M, Akiyama H
- Journal Title
  
  Int J Neurosci
  
  Volume: 124 Pages: 344-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Distinct pathways leading to TDP-43-induced cellular dysfunctions.2014
- Author(s)
  Yamashita M, Nonaka T, Hirai S, Miwa A, Okado H, Arai T, Hosokawa M, Akiyama H, Hasegawa M
- Journal Title
  
  Hum Mol Genet
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] C9ORF72 repeat-associated non-ATG-translated polypeptides are distributed independently of TDP-43 in a Japanese patient with c9ALS2014
- Author(s)
  Konno T　ほか
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume: 40 Issue: 6 Pages: 783-788
- DOI
  10.1111/nan.12157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22129004, KAKENHI-PROJECT-25430048, KAKENHI-PROJECT-25670417, KAKENHI-PLANNED-26117005, KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-26250017
[Journal Article] Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.2014
- Author(s)
  Davidson YS, Barker H, Robinson AC, Thompson JC, Harris J, Troakes C, Smith B, Al-Saraj S, Shaw C, Rollinson S, Masuda-Suzukake M, Hasegawa M, Pickering-Brown S, Snowden JS, Mann DM.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 2 Issue: 1 Pages: 70-70
- DOI
  10.1186/2051-5960-2-70
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117005
[Journal Article] Tau accumulation in the nucleus accumbens in tangle-predominant dementia.2014
- Author(s)
  Kawakami I, Hasegawa M, Arai T, Ikeda K, Oshima K, Niizato K, Aoki N, Omi K, Higashi S, Hosokawa M, Hirayasu Y, Akiyama H
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.2014
- Author(s)
  Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda-Suzukake M, Tamaoka A, Hasegawa M, Akiyama H.
- Journal Title
  
  Int. J. Neurosci.
  
  Volume: 124 Issue: 5 Pages: 344-349
- DOI
  10.3109/00207454.2013.848440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-25110738
[Journal Article] C9ORF72 repeat-associated non-ATG-translated　polypeptides are distributed independently of TDP-43 in a Japanese patient with c9ALS.2014
- Author(s)
  Konno T, Tada M, Shiga A, Tsujino A, Eguchi H, Masuda-Suzukake M, Hasegawa M, Nishizawa M, Onodera O, Kakita K, Takahashi H.
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume: 40 Pages: 783-788
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25110738
[Journal Article] Pathological alpha-synuclein propagates through neural networks2014
- Author(s)
  Masuda-Suzukake M, Nonaka T, Hosokawa M, Kubo M, Shimozawa A, Akiyama H, Hasegawa M
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 2 Issue: 1 Pages: 88-88
- DOI
  10.1186/preaccept-1296467154135944
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117005
[Journal Article] Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.2013
- Author(s)
  Moujalled D, James JL, Parker SJ, Lidgerwood GE, Duncan C, Meyerowitz J, Nonaka T, Hasegawa M, Kanninen KM, Grubman A, Liddell JR, Crouch PJ, White AR.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 6 Pages: e67433-e67433
- DOI
  10.1371/journal.pone.0067433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PUBLICLY-25110738
[Journal Article] Prion-like spreading of pathological alpha-synuclein in brain.2013
- Author(s)
  Masuda-Suzukake M, Nonaka T, Hosokawa M., Oikawa T, Arai T, Akiyama H, Mann D, Hasegawa M
- Journal Title
  
  Brain
  
  Volume: 136 Issue: 4 Pages: 1128-38
- DOI
  10.1093/brain/awt037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-25110738, KAKENHI-PUBLICLY-23110526
[Journal Article] A longitudinal study on alpha-synuclein in blood plasma as a biomarker for Parkinson's disease2013
- Author(s)
  Foulds PG, Diggle P, Mitchell D, Parker A, Hasegawa M, Masuda-Suzukake M, Mann DMA, Allsop D
- Journal Title
  
  Sci. Rep
  
  Volume: 3 Pages: 2540-2540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] A longitudinal study on alpha-synuclein in blood plasma as a biomarker for Parkinson’s disease.2013
- Author(s)
  Foulds PG, Diggle P, Mitchell D, Parker A, Hasegawa M, Masuda-Suzukake M, Mann DMA, Allsop D.
- Journal Title
  
  Sci. Rep.
  
  Volume: 3 Issue: 1 Pages: 2540-2540
- DOI
  10.1038/srep02540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-25110738
[Journal Article] Prion-like spreading of pathological alpha-synuclein in brain2013
- Author(s)
  Masuda-Suzukake M, Nonaka T, Hosokawa M., Oikawa T, Arai T, Akiyama H, Mann D, Hasegawa M
- Journal Title
  
  Brain
  
  Volume: 136 (Pt 4) Pages: 1128-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases.2013
- Author(s)
  Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H
- Journal Title
  
  J Neurol Sci
  
  Volume: 335 Pages: 89-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Dipeptide repeat proteins are present in the p62 positive inclusions in patients with Frontotemporal Lobar Degeneration and Motor Neuron Disease associated with expansions in C9ORF722013
- Author(s)
  Mann DMA, Rollinson S, Robinson AC, Callister J, Snowden JS, Gendron T, Petrucelli L, Masuda- Suzukake M, Hasegawa M, Davidson YS and Pickering-Brown S
- Journal Title
  
  Acta Neuropathol. Commun
  
  Volume: 1 (1) Pages: 68-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases.2013
- Author(s)
  Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H.
- Journal Title
  
  Neurol. Sci.
  
  Volume: 335 Issue: 1-2 Pages: 89-95
- DOI
  10.1016/j.jns.2013.08.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591714, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-25110738
[Journal Article] Prion-like spreadding of pathological alpha-synuclein in brain.2013
- Author(s)
  Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, Mann D, Hasegawa M
- Journal Title
  
  Brain
  
  Volume: 136 Pages: 1128-1138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain.2013
- Author(s)
  Dan A, Takahashi M, Masuda-Suzukake M, Kametani F, Nonaka T, Kondo H, Akiyama H, Arai T, Mann DMA, Saito Y, Hatsuta H, Murayama S, Hasegawa M.
- Journal Title
  
  Acta Neuropathol. Commun.
  
  Volume: 1 Issue: 1 Pages: 54-54
- DOI
  10.1186/2051-5960-1-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24700371, KAKENHI-PUBLICLY-25110738
[Journal Article] Isomerase Pin1 Stimulates Dephosphorylation of Tau Protein at Cyclin-dependent Kinase (Cdk5)-dependent Alzheimer Phosphorylation Sites2013
- Author(s)
  Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, and Shin-ichi Hisanaga
- Journal Title
  
  THE JOURNAL OF BIOLOGICAL CHEMISTRY
  
  Volume: 288 Issue: 11 Pages: 7968-7977
- DOI
  10.1074/jbc.m112.433326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06148, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-25110738, KAKENHI-PROJECT-25290024, KAKENHI-PUBLICLY-23110526
[Journal Article] Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain2013
- Author(s)
  Dan A, Takahashi M, Masuda-Suzukake M, Kametani F, Nonaka T, Kondo H, Akiyama H, Arai T, Mann DMA, Saito Y, Hatsuta H, Murayama S, Hasegawa M
- Journal Title
  
  Acta Neuropathol. Commun
  
  Volume: 1 (1) Pages: 54-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] Dipeptide repeat proteins are present in the p62 positive inclusions in patients with Frontotemporal Lobar Degeneration and Motor Neuron Disease associated with expansions in C9ORF72.2013
- Author(s)
  Mann DMA, Rollinson S, Robinson AC, Callister J, Snowden JS, Gendron T, Petrucelli L, Masuda-Suzukake M, Hasegawa M, Davidson YS and Pickering-Brown S.
- Journal Title
  
  Acta Neuropathol. Commun.
  
  Volume: 1 Issue: 1 Pages: 68-68
- DOI
  10.1186/2051-5960-1-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-25110738
[Journal Article] Prion-like properties of pathological TDP-43 aggregates from diseased brains.2013
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DMA, Akiyama H, Hasegawa M
- Journal Title
  
  Cell Rep
  
  Volume: 4 Pages: 124-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Pin1 stimulates dephosphorylation of tau at Cdk5- dependent Alzheimer phosphorylation sites2013
- Author(s)
  Kimura T, Tsutsumi K, Taoka M, Saito T, Masuda-Suzukake M, Ishiguro K, Plattner F, Uchida T, Ishobe T, Hasegawa M, Hisanaga SI
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288(11) Pages: 7968-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains.2013
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa M.
- Journal Title
  
  Cell Rep.
  
  Volume: 4 Issue: 1 Pages: 124-34
- DOI
  10.1016/j.celrep.2013.06.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PUBLICLY-25110738
[Journal Article] Orexin receptor-1 in the locus coeruleus plays an important role in cue- dependent fear memory consolidation.2013
- Author(s)
  Soya S, Shoji H, Hasegawa E, Hondo M, Miyakawa T, Yanagisawa M, Mieda M, Sakurai T.
- Journal Title
  
  J Neurosci.
  
  Volume: 33 Issue: 36 Pages: 14549-57
- DOI
  10.1523/jneurosci.1130-13.2013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J00940, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23659134, KAKENHI-PUBLICLY-24111546, KAKENHI-PROJECT-24390052, KAKENHI-PUBLICLY-25116526, KAKENHI-PUBLICLY-25126708
[Journal Article] Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains2013
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa
- Journal Title
  
  Cell Rep
  
  Volume: 4(1) Pages: 124-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] レビ-小体型認知症の神経変性機序・分子生物学2012
- Author(s)
  野中隆, 新井哲明, 水上勝義, 長谷川成人
- Journal Title
  
  老年精神医学雑誌
  
  Volume: 23 Pages: 353-358
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Molecular analysis and biochemical classificationof TDP-43 proteinopathy Brain.2012
- Author(s)
  Tsuji H, Arai T, Kametani F, Nonaka T, Yamashita M, Suzukake M, Hosokawa M, Yoshida M, Hatsuta H, Takao M, Saito Y, Murayama S, Akiyama H, Hasegawa M, David M. A. Mann, Tamaoka A
- Journal Title
  
  Brain
  
  Volume: 135 Pages: 3380-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0003
[Journal Article] 前頭側頭葉変性症の分子医学2012
- Author(s)
  新井哲明, 細川雅人, 野中隆, 長谷川成人, 秋山治彦, 朝田隆
- Journal Title
  
  Dementia Japan
  
  Volume: 26 Pages: 334-342
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Post mortem cerebrospinal fluidα-synuclein levels are raised in multiple system atrophy and distinguish this from the otherα-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies2012
- Author(s)
  Foulds PG, Yokota O, Thurston A, Davidson Y, Ahmed Z, Holton J, Thompson JC, Akiyama H, Arai T, Hasegawa M, Gerhard A, Allsop D, Mann DM
- Journal Title
  
  Neurobiol Dis
  
  Volume: 45 Issue: 1 Pages: 188-95
- DOI
  10.1016/j.nbd.2011.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PUBLICLY-23110526, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694
[Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy2012
- Author(s)
  Tsuji1 H, Arai T, Kametani F, Nonaka T, Yamashita M, Suzukake M, Hosokawa M, Yoshida M, Hatsuta H, Takao M, Saito Y, Murayama M, Akiyama H, Hasegawa M, Mann DMA, Tamaoka A
- Journal Title
  
  Brain
  
  Volume: 135 Pages: 3380-3391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy.2012
- Author(s)
  Tsuji H, Arai T, Kametani F, Nonaka T, Yamashita M, Suzukake M, Hosokawa M, Yoshida M, Hatsuda H, Takao M, Saito Y, Murayama S, Akiyama H, Hasegawa M, Mann DMA, Tamaoka A
- Journal Title
  
  Brain
  
  Volume: 135 Pages: 3380-3391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice.2012
- Author(s)
  Hosokawa M
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 12 Pages: e52389-e52389
- DOI
  10.1371/journal.pone.0052389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-23110526
[Journal Article] レビ-小体型認知症の神経変性機序・分子生物学.2012
- Author(s)
  野中隆, 新井哲明, 水上勝義, 長谷川成人
- Journal Title
  
  老年精神医学雑誌
  
  Volume: 23 Pages: 353-358
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Methylene blue reduced phosphorylated tau accumulation in P301L tau transgenic mice.2012
- Author(s)
  Hosokawa M, Arai T, Masuda-Suzukake M, Yamashita M, Nonaka T, Akiyama H, Hasegawa M
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson’s disease and Dementia with Lewy bodies.2012
- Author(s)
  Foulds PG, Yokota O, Thurston A, Davidson Y, Ahmed Z, Holton J, Thompson JC, Akiyama H, Arai T, Hasegawa M, Gerhard A, Allsop D, Mann DMA
- Journal Title
  
  Neurobiol Dis
  
  Volume: 45 Pages: 188-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration2012
- Author(s)
  Tsuji H, Nonaka T, Yamashita M, Suzukake M, Kametani F, Akiyama H, Mann DM, Tamaoka A and Hasegawa M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 417 Pages: 116-121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy2012
- Author(s)
  Tsuji H
- Journal Title
  
  Brain
  
  Volume: 135(11) Issue: 11 Pages: 3380-91
- DOI
  10.1093/brain/aws230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22590968, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23500435, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PROJECT-24300133, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591249, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-23110526
[Journal Article] 前頭側頭葉変性症の分子医学.2012
- Author(s)
  新井哲明, 細川雅人, 野中隆, 長谷川成人, 秋山治彦, 朝田隆
- Journal Title
  
  Dementia Japan
  
  Volume: 26 Pages: 334-342
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] TDP-43分子による新たな認知症群2011
- Author(s)
  新井哲明, 細川雅人, 長谷川成人, 秋山治彦, 朝田隆
- Journal Title
  
  精神経誌
  
  Volume: 113 Pages: 574-583
- NAID
  10029576302
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] ALSD-FTLD-MND-FTLD-U2011
- Author(s)
  新井哲明, 小林禅, 細川雅人, 長谷川成人, 秋山治彦
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 29 Pages: 995-998
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] In vitro recapitulation of aberrant protein inclusions in neurodegenerative diseases…2011
- Author(s)
  Nonaka T, Hasegawa M
- Journal Title
  
  Integ Biol
  
  Volume: 4 Pages: 501-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] In vitro recapitulation of aberrant protein inclusions in neurodegeneraitive diseases…2011
- Author(s)
  Nonaka T, Hasegawa M
- Journal Title
  
  Integ Biol
  
  Volume: 4 Pages: 501-502
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23110526
[Journal Article] 前頭側頭葉変性症の分子病理2011
- Author(s)
  新井哲明, 山下万貴子, 細川雅人, 野中隆, 小林禅, 長谷川成人, 秋山治彦, 朝田隆
- Journal Title
  
  Dementia Japan
  
  Volume: 25 Pages: 120-128
- NAID
  10026310255
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Clinicopathological study of diffuse neurofibrillary tangles with calcification - With special reference to TDP-43 proteinopathy and alpha-synucleinopathy -2011
- Author(s)
  Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N
- Journal Title
  
  J Neurol Sci
  
  Volume: 301 Pages: 77-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] 病理構造物の解析からみちびかれた精神神経疾患の新しい考え方2011
- Author(s)
  長谷川成人, 新井哲明, 野中隆, 亀谷富由樹, 秋山治彦
- Journal Title
  
  精神医学
  
  Volume: 53 Pages: 1201-1206
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Molecular Dissection of TDP-43 Proteinopathies2011
- Author(s)
  Hasegawa M, Nonaka T, Tsuji H, Tamaoka A, Yamashita M, Kametani F, Yoshida M, Arai T, Akiyama H
- Journal Title
  
  J Mol Neurosci
  
  Volume: 45 Pages: 480-485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] 病理構造物の解析からみちびかれた精神神経疾患の新しい考え方2011
- Author(s)
  長谷川成人, 他
- Journal Title
  
  精神医学
  
  Volume: 53 Pages: 1201-1206
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23110526
[Journal Article] 病理構造物の解析からみちびかれた精神神経疾患の新しい考え方2011
- Author(s)
  長谷川成人, 他
- Journal Title
  
  精神医学
  
  Volume: 53 Pages: 1201-1206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050
[Journal Article] Molecular Dissection of TDP-43 Proteinopathies2011
- Author(s)
  Hasegawa M, Nonaka T, Tsuji H, et al
- Journal Title
  
  J Mol Neurosci
  
  Volume: 45(3) Issue: 3 Pages: 480-5
- DOI
  10.1007/s12031-011-9571-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500339, KAKENHI-PROJECT-21591536, KAKENHI-PUBLICLY-23110526, KAKENHI-PROJECT-23591694
[Journal Article] Molecular dissection of TDP-43 proteinopathies.2011
- Author(s)
  Hasegawa M, Nonaka T, Tsuji H, Tamaoka A, Yamashita M, Kametani F, Yoshida M, Arai T, Akiyama H
- Journal Title
  
  J Mol Neurosci
  
  Volume: 45 Pages: 480-485
- Data Source
  KAKENHI-PROJECT-23591694
[Journal Article] Clinicopathological study of diffuse neurofibrillary tangles with calcification. With special reference to TDP-43 proteinopathy and alpha-synucleinopathy2011
- Author(s)
  Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N
- Journal Title
  
  J Neurol Sci
  
  Volume: 301 Issue: 1-2 Pages: 77-85
- DOI
  10.1016/j.jns.2010.10.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PUBLICLY-23110526, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694
[Journal Article] TDP-43リン酸化の意義2010
- Author(s)
  亀谷富由樹, 新井哲明, 長谷川成人
- Journal Title
  
  Clinical Neuroscience 28
  
  Pages: 128-129
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy2010
- Author(s)
  新井哲明, 長谷川成人(他10名)
- Journal Title
  
  Neuropathology (印刷中)
- NAID
  10029320452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] 前頭側頭葉変性症の分子病理2010
- Author(s)
  藤城弘樹、長谷川成人、新井哲明
- Journal Title
  
  精神経誌 (印刷中)
- NAID
  10026310255
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] 筋萎縮性側索硬化症(ALS)マウス2010
- Author(s)
  野中隆, 新井哲明, 長谷川成人
- Journal Title
  
  モデル動物利用マニュアル (印刷中)
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Characterization of inhibitor-bound alpha-synuclein dimer : role of alpha-synuclein N-terminal region in dimerization and inhibitor binding.2010
- Author(s)
  Yamaguchi Y, Masuda M, Sasakawa H, Nonaka T, Hanashima S, Hisanaga SI, Kato K, Hasegawa M.
- Journal Title
  
  J Mol Biol 395
  
  Pages: 445-456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023038
[Journal Article] 神経変性疾患の新規原因分子:TDP-432009
- Author(s)
  新井哲明, 長谷川成人, 他5名
- Journal Title
  
  実験医学 27
  
  Pages: 1324-1332
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.2009
- Author(s)
  Yamashita M, Nonaka T, Arai T, Kametani F, Buchman VL, Ninkina N, Bachurin SO, Akiyama H, Goedert M, Hasegawa M.
- Journal Title
  
  FEBS Lett 583
  
  Pages: 2419-2424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023038
[Journal Article] Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.2009
- Author(s)
  Arai T, Mackenzie IRA, Hasegawa M, 他6名
- Journal Title
  
  Acta Neuropathol 117
  
  Pages: 125-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies2009
- Author(s)
  Arai T Mackenzie IR, Hasegawa M, Nonaka T, Niizato K, Tsuchiya K, Iritani S, Onaya M, Akiyama H
- Journal Title
  
  Acta Neuropathol. 117
  
  Pages: 125-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] A Cellular Model To Monitor Proteasome Dysfunction by alpha-Synuclein.2009
- Author(s)
  Nonaka T, Hasegawa M.
- Journal Title
  
  Biochemistry 48
  
  Pages: 8014-8022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023038
[Journal Article] 細胞内TDP-43蓄積のメカニズム2009
- Author(s)
  野中隆, 新井哲明, 長谷川成人
- Journal Title
  
  Brain and Nerve 61
  
  Pages: 1392-1400
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing.2009
- Author(s)
  Davidson Y, Amin H, Kelley T, Shi J, Tian J, Kumaran R, Lashley T, Lees AJ, Duplessis D, Neary D, Snowden J, Akiyama H, Arai T, Hasegawa M, et al.
- Journal Title
  
  Acta Neuropathol. [Epub ahead of print]
  
  Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Conversion of wild-type α-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant.2009
- Author(s)
  Yonetani M, Nonaka T, Masuda M, Inukai Y, Oikawa T, Hisanaga S, Hasegawa M.
- Journal Title
  
  J Biol Chem 284
  
  Pages: 7940-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells.2009
- Author(s)
  Nonaka T, Arai T, Buratti E, Baralle F, Akiyama H, Hasegawa M
- Journal Title
  
  FEBS Lett 583
  
  Pages: 394-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Inhibition of alpha-synuclein fibril assembly by small molecules : Analysis using epitope-specific antibodies.2009
- Author(s)
  Masuda M, Hasegawa M. Nonaka T, Oikawa T, Yonetani M, Yamaguchi Y, Kato K, Hisanaga S, Goedert M.
- Journal Title
  
  FEBS Lett 583
  
  Pages: 787-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023038
[Journal Article] Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease.2009
- Author(s)
  Fujishiro H, Uchikado H, Arai T, Hasegawa M, 他6名
- Journal Title
  
  Acta Neuropathol 117
  
  Pages: 151-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] TDP-43 proteinopathy―その広がりと病因的意義2009
- Author(s)
  長谷川成人, 野中隆, 新井哲明, 秋山治彦
- Journal Title
  
  Annual Review 神経2010
  
  Pages: 187-195
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Identification of casein kinase-1 phosphorylation sites on TDP-43.2009
- Author(s)
  Kametani F, Nonaka T, Suzuki T, Arai T, Dohmae N, Akiyama H, Hasegawa M.
- Journal Title
  
  Biochem Biophys Res Commun. 382
  
  Pages: 405-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] TDP-43 pathology in familial British dementia.2009
- Author(s)
  Schwab C, Arai T, Hasegawa M, Akiyama H, Yu S, McGeer PL.
- Journal Title
  
  Acta Neuropathol. [Epub ahead of print]
  
  Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Inhibition of α-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies.2009
- Author(s)
  Masuda M, Hasegawa M, Nonaka T, Oikawa T, Yonetani M, Yamaguchi Y, Kato K, Hisanaga S, Goedert M.
- Journal Title
  
  FEBS Lett 583
  
  Pages: 787-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.2009
- Author(s)
  Nonaka T, Kametanil F, Arai T, Akiyama H, Hasegawa M.
- Journal Title
  
  Hum Mol Genet 18
  
  Pages: 3353-3364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023038
[Journal Article] Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells.2009
- Author(s)
  Nonaka T, Arai T, Buratti E, Baralle FE, Akiyama H, Hasegawa M.
- Journal Title
  
  FEBS Lett 583
  
  Pages: 394-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.2009
- Author(s)
  Hasegawa M, et al
- Journal Title
  
  Ann Neurol 64
  
  Pages: 60-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023038
[Journal Article] Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-432009
- Author(s)
  Nonaka T, Kametani F, Arai T, Akiyama H, Hasegawa M
- Journal Title
  
  Hum Mol Genetics 18
  
  Pages: 3353-3364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] 神経変性疾患とTDP-432009
- Author(s)
  長谷川成人, 野中隆, 新井哲明
- Journal Title
  
  最新医学 64
  
  Pages: 125-131
- NAID
  40016527454
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis2009
- Author(s)
  Hasegawa M, et al
- Journal Title
  
  Ann Neurol 64
  
  Pages: 60-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Conversion of wild-type alpha -synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant.2009
- Author(s)
  Yonetani M, Nonaka T, Masuda M, Inukai Y, Oikawa T, Hisanaga SI, Hasegawa M.
- Journal Title
  
  J Biol Chem 284
  
  Pages: 7940-7950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023038
[Journal Article] TDP-43とFTLD-U研究の新展開.2008
- Author(s)
  新井哲明, 長谷川成人, 野中隆, 亀谷富由樹, 秋山治彦
- Journal Title
  
  Dementia Japan (印刷中)
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Colocalization of TDP-43 and Huntingtin in inclusions of Huntington's disease2008
- Author(s)
  Schwab C, Arai T, Hasegawa M, Yu S McGeer PL
- Journal Title
  
  J Neurolpathol Exp Neurol 67
  
  Pages: 1159-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease.2008
- Author(s)
  Fujishiro H, Uchikado H, Arai T, Hasegawa M, Akiyama H, Yokota O, Tsuchiya K, Togo T, Iseki E.
- Journal Title
  
  Acta Neuropathol. 117
  
  Pages: 151-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] FTLD/ALSにおけるTDP-43蓄積2008
- Author(s)
  新井哲明, 長谷川成人, 他3名
- Journal Title
  
  神経内科 68
  
  Pages: 540-547
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Phosphorylated TDP-43 in frontotemporal lobar degeneration and ALS2008
- Author(s)
  Hasegawa M, Arai T(他13名)
- Journal Title
  
  Ann Neurol (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.2008
- Author(s)
  Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Exp Neurol 210
  
  Pages: 409-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Phosphorylated TDP-43 in frontotemporal lobar degeneration and ALS.2008
- Author(s)
  Hasegawa M, Arai T, 他13名
- Journal Title
  
  Ann Neurol 64
  
  Pages: 60-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.2008
- Author(s)
  Inukai Y, Nonaka T, Arai T, Yoshida M, Hashizume Y, Beach TG, Buratti E, Baralle FE, Akiyama H, Hisanaga SI, Hasegawa M,
- Journal Title
  
  FEBS Lett 582
  
  Pages: 2289-2904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] TDP-43と神経変性疾患2008
- Author(s)
  長谷川成人, 新井哲明
- Journal Title
  
  BIO Clinica 23
  
  Pages: 61-64
- NAID
  40016469891
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Phosphorylated TDP-43 in Frontotemporal lobar degeneration and ALS.2008
- Author(s)
  *Hasegawa, M., *Arai, T., Nonaka, T., Kametani, F., et. al.
- Journal Title
  
  Ann.Neurol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] タウパチーの生化学、分子生物学2008
- Author(s)
  青柳浩史、長谷川成人
- Journal Title
  
  Cognition & Dementia 7
  
  Pages: 127-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] TDP-43(TAR DNA-binding protein of 43 kDa)とその意義.2008
- Author(s)
  新井哲明、長谷川成人
- Journal Title
  
  Clin.Neurosci. 26
  
  Pages: 301-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] 前頭側頭変性症(FTLD)とゲノム.2008
- Author(s)
  新井哲明, 長谷川成人, 秋山治彦
- Journal Title
  
  ゲノム医学 (印刷中)
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Phosphorylated TDP-43 in frontotemproal lobar degeneration and ALS2008
- Author(s)
  *Hasegawa, M., *Arai, T., Nonaka, T., Kametani, F., et. al
- Journal Title
  
  Ann.Neurol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] TDP-43(TAR DNA-binding protein of 43 kDa)とその意義.2008
- Author(s)
  新井哲明、長谷川成人
- Journal Title
  
  Clinical Neuroscience 26
  
  Pages: 301-302
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] FTLD-Uにおけるユビキチン陽性封入体のタンパク化学2008
- Author(s)
  長谷川成人, 新井哲明, 他3名
- Journal Title
  
  神経内科 68
  
  Pages: 532-539
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.2008
- Author(s)
  Obi, K., *Akiyama, H., Kondo, H. Shimomura, Y., Hasegawa, M., et. al.
- Journal Title
  
  Exp.Neurol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] FTLD-Uにおけるユビキチン陽性封入体のタンパク化学.2008
- Author(s)
  長谷川成人, 新井哲明, 野中隆, 亀谷富由樹, 秋山治彦
- Journal Title
  
  神経内科 (印刷中)
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] TDP-43(TAR DNA-binding protein of 43kDa)とその意義.2008
- Author(s)
  新井哲明、長谷川成人
- Journal Title
  
  Clin.Neurosci. 26
  
  Pages: 301-302
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] FTLD/ALSにおけるTDP-43蓄積.2008
- Author(s)
  新井哲明, 長谷川成人, 野中隆, 亀谷富由樹, 秋山治彦
- Journal Title
  
  神経内科 (印刷中)
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] FTDにおけるTDP-43蓄積の意義2008
- Author(s)
  長谷川成人, 新井哲明, 他10名
- Journal Title
  
  臨床神経 48
  
  Pages: 994-997
- NAID
  10024898781
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.2008
- Author(s)
  Hasegawa M, Arai T, Nonaka T, Kametani F, Yoshida M, Hashizume Y, Beach TG, Buratti E, Baralle F, Morita M, Nakano I, Oda T, Tsuchiya K, Akiyama H
- Journal Title
  
  Ann Neurol 64
  
  Pages: 60-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] タウパチーの生化学、分子生物学2008
- Author(s)
  青柳浩史、長谷川成入
- Journal Title
  
  Cogniton & Dementia 7
  
  Pages: 127-135
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] シヌクレイノパチーの基礎研究における最近の進歩.2007
- Author(s)
  野中隆、増田雅美、長谷川成人
- Journal Title
  
  Dementia Japan 21
  
  Pages: 8-14
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] タウとアルツハイマー病。2007
- Author(s)
  笈川貴行、長谷川成人
- Journal Title
  
  医学のあゆみ 220
  
  Pages: 374-378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] ALSでみられるユビキチン化封入体の構成蛋白.2007
- Author(s)
  長谷川成人、新井哲明
- Journal Title
  
  Brain & Nerve 59
  
  Pages: 1171-1177
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] ALSでみられるユビキチン化封入体の構成蛋白.2007
- Author(s)
  長谷川成人、新井哲明
- Journal Title
  
  Brain & Nerve 59
  
  Pages: 1171-1177
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.2007
- Author(s)
  Hasegawa M, Arai T, 他6名
- Journal Title
  
  Brain 130
  
  Pages: 1386-1394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] タウ、プログラニュリン、TDP-43と神経変性.2007
- Author(s)
  長谷川成人、新井哲明
- Journal Title
  
  実験医学 25
  
  Pages: 53-61
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] FTLDおよびALS出現するユビキチン陽性封入体の主要構成成分としてのTDP-43の同定.2007
- Author(s)
  新井哲明、秋山治彦、長谷川成人
- Journal Title
  
  Dementia Japan 21
  
  Pages: 89-103
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] TDP-43と神経変性疾患.2007
- Author(s)
  長谷川成人、新井哲明
- Journal Title
  
  BIO Clinica 23
  
  Pages: 61-64
- NAID
  40016469891
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] FTLDおよびALSに出現するユビキチン陽性封入体の主要構成成分としてのTDP-43の同定.2007
- Author(s)
  新井哲明、秋山治彦、長谷川成人
- Journal Title
  
  Dementia Japan 21
  
  Pages: 89-103
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.2007
- Author(s)
  Sato K, Zhu YS, Saito T, Yotsumoto K, Asada A, Hasegawa M, Hisanaga S.
- Journal Title
  
  J Neurosci Res. 85
  
  Pages: 3071-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] ピック病の分子生物学.2007
- Author(s)
  新井哲明、長谷川成人
- Journal Title
  
  老年精神医学雑誌 18
  
  Pages: 605-615
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] ピック病の分子生物学.2007
- Author(s)
  新井哲明、長谷川成人
- Journal Title
  
  老年精神医学雑誌 18
  
  Pages: 605-615
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] TDP-43と神経変性疾患.2007
- Author(s)
  長谷川成人、新井哲明
- Journal Title
  
  BIO CIinica 23
  
  Pages: 61-64
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] TDP-43と神経変性疾患。2007
- Author(s)
  長谷川成人、新井哲明
- Journal Title
  
  BIO Clinica 23
  
  Pages: 61-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] FTLDおよびALSに出現するユビキチン陽性封入体の主要構成成分としてのTDP-43の同定.2007
- Author(s)
  新井哲明, 秋山治彦, 長谷川成人
- Journal Title
  
  Dementia Japan 21
  
  Pages: 89-103
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] タウ、プログラニュリン、TDP-43と神経変性.2007
- Author(s)
  長谷川成人、新井哲明
- Journal Title
  
  実験医学 25
  
  Pages: 53-61
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Fibrillogenic nuclei composed of P301L mutant tau induce elongation of P301L tau, but not wild-type tau.2007
- Author(s)
  Aoyagi H, Hasegawa M, Tamaoka A
- Journal Title
  
  J Biol Chem 282
  
  Pages: 20309-20318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of alpha-synuclein.2007
- Author(s)
  Sasakawa, H., Sakata, E., Yamaguchi, Y., Masuda, M., Mori, T., Kurimoto, E., Iguchi, T., Hisanaga, S., Iwatsubo, T., Hasegawa, M., & *Kato K
- Journal Title
  
  Biochem.Biophys.Res.Commun. 363
  
  Pages: 795-799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] α-シヌクレイン.2007
- Author(s)
  野中隆、増田雅美、長谷川成人
- Journal Title
  
  日本臨床 66
  
  Pages: 102-106
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] FTLDおよびALSに出現するユビキチン陽性封入体の主要構成成分としてのTDP-43の同定.2007
- Author(s)
  新井哲明、秋由治彦、長谷川成人
- Journal Title
  
  Dementia Japan 21
  
  Pages: 89-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] タウ、プログラニュリン、TDP-43と神経変性.2007
- Author(s)
  長谷川成人、新井哲明
- Journal Title
  
  実験医学 25
  
  Pages: 53-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] ALSでみられるユビキチン化封入体の構成蛋白.2007
- Author(s)
  長谷川成人、新井哲明
- Journal Title
  
  Brain & Nerve 59
  
  Pages: 1171-1177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] Regulation of membrane association andkinase activity of Cdk5-p35 by phosphortlation of p352007
- Author(s)
  Sato, K., Zhu, Y. S., Saito, T., Yotsumoto, K., Asada A., Hasegawa, M.& *Hosanaga. S.
- Journal Title
  
  J.Neurosci.Res. 85
  
  Pages: 3071-3078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.2007
- Author(s)
  Hasegawa, M., *Arai, T., Akiyama, H., Nonaka, T., et. al
- Journal Title
  
  Brain 130
  
  Pages: 1386-1394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains2007
- Author(s)
  Hasegawa M, Arai T(他6名)
- Journal Title
  
  Brain 130
  
  Pages: 1386-1394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591024
[Journal Article] Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.2007
- Author(s)
  Ishii A, Nonaka T, Taniguchi S, Saito T, Arai T, Mann D, Iwatsubo T, Hisanaga SI, Goedert M, Hasegawa M
- Journal Title
  
  FEBS Lett 581
  
  Pages: 4711-4717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Fibrillogenic nuclei compqsed of P30IL mutant tau induce elongation of P30IL tau, but not wild-type tau.2007
- Author(s)
  Aoyagi, H., *Hasegawa, M. & Tamaoka, A.
- Journal Title
  
  J.Biol.Chem 282
  
  Pages: 20309-20318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.2007
- Author(s)
  Hasegawa, M., *Arai, T., Akiyama, H., Nonaka, T., et. al.
- Journal Title
  
  Brain 130
  
  Pages: 1386-1394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein:Implication for alpha-synucleinopathies.2007
- Author(s)
  Ishii, A., Nonaka, T., Taniguchi S., Saito, T., Arai, T., Mann, D., Iwatsubo, T., Hisanaga, S., Goedert, M. & *Hasegawa, M.
- Journal Title
  
  FEBS Lett. 581
  
  Pages: 4711-4717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Fibrillogenic nuclei composed of P30IL mutant tau induce elongation of P30IL tau,but not wild-type tau.2007
- Author(s)
  Aoyagi, H., *Hasegawa, M., & Tamaoka, A.
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 20309-20318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] タウとアルツハイマー病.2007
- Author(s)
  笈川貴行、長谷川成人
- Journal Title
  
  医学のあゆみ, 220
  
  Pages: 374-378
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of alpha-synuclein.2007
- Author(s)
  Sasakawa H, Sakata E, Yamaguchi Y, Masuda M, Mori T, Kurimoto E, Iguchi T, Hisanaga SI, Iwatsubo T, Hasegawa M, Kato K
- Journal Title
  
  Biochem Biophys Res Commun 363
  
  Pages: 795-799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.2007
- Author(s)
  Sato, K., Zhu, Y. S., Saito, T., Yotsumoto, K., Asada, A., Hasegawa, M. & *Hisanaga, S.
- Journal Title
  
  J.Neuroscz.Res. 85
  
  Pages: 3071-3078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] ピック病の分子生物学.2007
- Author(s)
  新井哲明、長谷川成人
- Journal Title
  
  老年精神医学雑誌 18
  
  Pages: 605-615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] シヌクレイノパチーの基礎研究における最近の進歩.2007
- Author(s)
  野中隆、増田雅美、長谷川成人
- Journal Title
  
  Dementia Japan 21
  
  Pages: 8-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.2007
- Author(s)
  Hasegawa M, Arai T, Akiyama H, Nonaka T, Mori H, Hashimoto T, Yamazaki M, Oyanagi K.
- Journal Title
  
  Brain 130
  
  Pages: 1386-1394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] . Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of alpha-synuclein2007
- Author(s)
  Sasakama, H., Sakata, E., Yamaguchi, Y., Masuda, M., Mori, T, . Kurimoto, E., Iguchi, T, . Hisanaga, S., Iwatsubo, T., Hasegawa, M., & *Kato K
- Journal Title
  
  Biochem.Biophys.Res.Commun 363
  
  Pages: 795-799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alphy-synuclein; Implication for alpha-synucleinopathies.2007
- Author(s)
  Ishii, A., Nonaka, T., Taniguchi, S., Saito, T., Arai, T., Mann, D., Iwatsubo, T., Hisanaga, S., Godert, M. & *Hasegawa, M.
- Journal Title
  
  FEBS Lett. 581
  
  Pages: 4711-4717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] α-シヌクレイン.2007
- Author(s)
  野中隆、増田雅美、長谷川成人
- Journal Title
  
  日本臨床 66
  
  Pages: 102-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006
- Author(s)
  Wakabayashi K, Mori F, Hasegawa M, Kusumi T, Yoshimura I, Takahashi H, Kaneko S
- Journal Title
  
  Neuropathology 26
  
  Pages: 66-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.2006
- Author(s)
  Hasegawa, M., Arai, T., Akiyama, H., Nonaka, T., Mori, H., Hashimoto, T., Yamazaki, M., Oyanagi, K.
- Journal Title
  
  Brain (in press)
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] Small Molecule Inhibitors of alpha-Synuclein Filament Assembly.2006
- Author(s)
  Masuda, M., Szuki, N., Goedrt, M., Hasegawa, M.
- Journal Title
  
  Biochemistry (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Cysteine misincorporation in bacterially expressed human alpha-synuclein.2006
- Author(s)
  Masuda, M., Dohmae, N., Goedert,, Hasegawa, M.
- Journal Title
  
  FEBS Lett. 580
  
  Pages: 1775-79
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Biochemistry and molecular biology of tauopathies.2006
- Author(s)
  Hasegawa, M.
- Journal Title
  
  Neuropathology (in press)
- NAID
  10019264205
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Small Molecule Inhibitors of alpha-Synuclein Filament Assembly.2006
- Author(s)
  Masuda, M., Suzuki, N., Goedert, M., Hasegawa, M.
- Journal Title
  
  Biochemistry (in press)
- Data Source
  KAKENHI-PROJECT-17025052
[Journal Article] Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006
- Author(s)
  Wakabayashi K, Mori F, Hasegawa M, et al.
- Journal Title
  
  Neuropathology 26
  
  Pages: 66-71
- Data Source
  KAKENHI-PROJECT-17025052
[Journal Article] Pathological and biochemical studies on a case of Pick disease with severe white matter atrophy.2006
- Author(s)
  Yamakawa K, Takanashi M, Watanabe M, Nakamura N, Kobayashi T, Hasegawa M, Mizuno Y, Tanaka S, Mori H.
- Journal Title
  
  Neuropathology 26
  
  Pages: 586-591
- NAID
  10019264634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Cysteine misincorporation in bacterially expressed human alpha-synuclein.2006
- Author(s)
  Masuda M, Dohmae N, Nonaka T, Oikawa T, Hisanaga S, Goedert M, Hasegawa M
- Journal Title
  
  FEBS Lett 580
  
  Pages: 1775-1779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Cysteine misincorporation in bacterially expressed human alpha-synuclein.2006
- Author(s)
  Masuda, M., Dohmae, N., Nonaka, T., Oikawa, T., Hisanaga, S., Goedert, M., Hasegawa,M.
- Journal Title
  
  FEBS Lett. 580
  
  Pages: 1775-1779
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis2006
- Author(s)
  Arai, T., Hasegawa, M., Akiyama, H., Ikeda, K., Nonaka, T., Mori, H., Mann, D., Tsuchida, K., Yoshida, M., Hashizume,Y, Oda
- Journal Title
  
  Biochem.Biophys.Res.Commun 351
  
  Pages: 602-611
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Biochemistry and molecular biology of tauopathies.2006
- Author(s)
  Hasegawa, M.
- Journal Title
  
  Neuropathology 26
  
  Pages: 484-490
- NAID
  10019264205
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Pathological and biochemical studies on a case of Pick disease with severe white matter atrophy.2006
- Author(s)
  Yamakawa K, Takanashi M, Watabane M, Nakamura N, Kobayashi T, Hasegawa M, Mizuno Y, Tanaka S, Mori H
- Journal Title
  
  Neuropathology 26
  
  Pages: 586-591
- NAID
  10019264634
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Biochemistry and molecular biology of tauopathies.2006
- Author(s)
  Hasegawa, M.
- Journal Title
  
  Neuropathology 26
  
  Pages: 484-490
- NAID
  10019264205
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006
- Author(s)
  Wakabayashi, K., Mori, F., Hasegawa, M., Kusumi, T., Yoshimura, I., Takahashi, H., Kaneko,S.
- Journal Title
  
  Neuropathology 26
  
  Pages: 66-71
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Corticobasal degeneration with focal, massive tau accumulation in the subcortical white matter astrocytes.2006
- Author(s)
  Sakai K, Piao YS, Kikugawa K, Ohara S, Hasegawa M, Takano H, Fukase M, Nishizawa M, Kakita A, Takahashi H
- Journal Title
  
  Acta Neuropathol 112
  
  Pages: 341-348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.2006
- Author(s)
  Kim EJ, Sung JY, Lee HJ, Rhim H, Hasegawa M, Iwatsubo T, Min DS, Kim J, Paik SR, Chung KC
- Journal Title
  
  J Biol Chem 281
  
  Pages: 33250-33257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Cysteine misincorporation in bacterially expressed human alpha-synuclein.2006
- Author(s)
  Masuda, M., Dohmae, N., Goedert, M., Hasegawa, M.
- Journal Title
  
  FEBS Lett. 580
  
  Pages: 1775-1779
- Data Source
  KAKENHI-PROJECT-17025052
[Journal Article] DyrklA phosphorylates alpha-synuclein and enhances intracellular inclusion formation.2006
- Author(s)
  Kim, E.J., Sung, J.Y., Lee, H.J., Rhim, H., Hasegawa, M., Iwatsubo, T., Min, D.S., Kim.J., Paik, S.R., Chung,K.C.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 33250-33257
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Corticobasal degeneration with focal, massive tau accumulation in the subcortical white matter astrocytes.2006
- Author(s)
  Sakai, K., Piao, Y.S., Kikugawa, K., Ohara, S., Hasegawa, M., Takano, H., Fukase, M., Nishizawa, M., Kakita, A., Takahashi, H.
- Journal Title
  
  Acta Neuropathol. (Berl) 112
  
  Pages: 341-348
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.2006
- Author(s)
  Kim, E.J., Sung, J.Y., Lee, H.J., Rhim, H., Hasegawa, M., Iwatsubo, T., Min, D.S., Kim, J., Paik, S.R., Chung, K.C.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 33250-33257
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.2006
- Author(s)
  Arai T*, Hasegawa M*, Akiyama H, Ikeda K, Nonaka T, Mori H, Mann D, Tsuchiya K, Yoshida M, Hashizume Y, Oda T
- Journal Title
  
  Biochem Biophys Res Commun 351
  
  Pages: 602-611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Pathological and biochemical studies on a case of Pick disease with severe white matter atrophy.2006
- Author(s)
  Yamakawa K, Takanashi M, Watanabe M, Nakamura N, Kobayashi T, Hasegawa M, Mizuno Y, Tanaka S, Mori H
- Journal Title
  
  Neuropathology 26
  
  Pages: 586-591
- NAID
  10019264634
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] Cysteine misincorporation in bacterially expressed human alpha-synuclein.2006
- Author(s)
  Masuda, M., Dohmae, N., Nonaka, T., Oikawa, T., Hisanaga, S., Goedert, M., Hasegawa, M.
- Journal Title
  
  FEBS Lett. 580
  
  Pages: 1775-1779
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] Cysteine misincorporation in bacterially expressed human alpha-synuclein.2006
- Author(s)
  Masuda, M., Dohmae, N., Goedert, M., Hasegawa, M.
- Journal Title
  
  FEBS Lett. 580
  
  Pages: 1775-1779
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006
- Author(s)
  Wakabayashi K, Mori F, Hasegawa M, et al.
- Journal Title
  
  Neuropathology 26
  
  Pages: 66-71
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Small molecule inhibitors of alpha-synuclein filament assembly.2006
- Author(s)
  Masuda, M., Suzuki, N., Taniguchi, S., Oikawa, T., Nonaka, T., Iwatsubo, T., Hisanaga, S.I., Goedert, M., Hasegawa,M.
- Journal Title
  
  biochemistry 45
  
  Pages: 6085-6094
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Biochemistry and molecular biology of tauopathies.2006
- Author(s)
  Hasegawa, M.
- Journal Title
  
  Neuropathology (in press)
- NAID
  10019264205
- Data Source
  KAKENHI-PROJECT-17025052
[Journal Article] Corticobasal degeneration with focal, massive tau accumulation in the subcortical white matter astrocytes.2006
- Author(s)
  Sakai, K., Piao, Y.S, Kikugawa, K., Ohara, S., Hasegawa, M., Takano, H., Fukase, M., Nishizawa, M., Kakita, A., Takahashi,H.
- Journal Title
  
  Acta Neuropathol.(Berl) 112
  
  Pages: 341-348
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006
- Author(s)
  Wakabayashi, K., Mori, F., Hasegawa, M., Kusumi, T., Yoshimura, I., Takahashi, H., Kaneko, S.
- Journal Title
  
  Neuropathology 26
  
  Pages: 66-71
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.2006
- Author(s)
  Hasegawa, M., Arai, T., Akiyama, H., Nonaka, T., Mori, H., Hashimoto, T., Yamazaki, M., Oyanagi,K.
- Journal Title
  
  Brain (in press)
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Biochemistry and molecular biology of tauopathies.2006
- Author(s)
  Hasegawa M
- Journal Title
  
  Neuropathology 26
  
  Pages: 484-490
- NAID
  10019264205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis2006
- Author(s)
  Arai, T., Hasegawa, M., Akiyama, H., Ikeda, K., Nonaka, T., Mori, H., Mann, D., Tsuchiya, K., Yoshida, M., Hashizume, Y., Oda
- Journal Title
  
  Biochem. Biophys. Res. Commun 351
  
  Pages: 602-611
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] Small molecule inhibitors of alpha-synuclein filament assembly.2006
- Author(s)
  Masuda, M., Suzuki, N., Taniguchi, S., Oikawa, T., Nonaka, T., Iwatsubo, T., Hisanaga, S.I., Goedert, M., Hasegawa, M.
- Journal Title
  
  Biochemistry 45
  
  Pages: 6085-6094
- Data Source
  KAKENHI-PROJECT-18023042
[Journal Article] Small molecule inhibitors of alpha-synuclein filament assembly.2006
- Author(s)
  Masuda M, Suzuki N, Taniguchi S, Oikawa T, Nonaka T, Iwatsubo T, Hisanaga SI, Goedert M, Hasegawa M
- Journal Title
  
  Biochemistry 45
  
  Pages: 6085-6094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300117
[Journal Article] Small Molecule Inhibitors of alpha-Synuclein Filament Assembly.2006
- Author(s)
  Masuda, M., Suzuki, N., Goedert, M., Hasegawa, M.
- Journal Title
  
  Biochemistry (in press)
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006
- Author(s)
  Wakabayashi K, Mori F, Hasegawa M et sl.
- Journal Title
  
  Neuropathology 26
  
  Pages: 66-71
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins.2005
- Author(s)
  Taniguchi S, Suzuki N, Masuda M, Hisanaga SI, Iwatsubo T, Goedert M, Hasegawa M
- Journal Title
  
  J Biol Chem 280
  
  Pages: 7614-7623
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Unique tauopathy in Fukuyama-type congenital muscular dystrophy.2005
- Author(s)
  Saito, Y., N, Hasegawa, M., Murayama, S.
- Journal Title
  
  J.Neuropathol.Exp.Neurol 64
  
  Pages: 839-846
- Data Source
  KAKENHI-PROJECT-17025052
[Journal Article] Unique tauopathy in Fukuyama-type congenital muscular dystrophy2005
- Author(s)
  Saito, Y., N, Hasegawa, M, Murayama, S.
- Journal Title
  
  J. Neuropathol. Exp. Neurol 64
  
  Pages: 839-46
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.2005
- Author(s)
  Ikeda M, Hasegawa M, Westaway D, et al.
- Journal Title
  
  Am J Pathol 166
  
  Pages: 521-531
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Phosphorylation of FTDP-17 mutant TAU by cyclin-dependent kinase 5 complexed with p35,p25,or p39.2005
- Author(s)
  Sakaue, F., Saito, T., Hasegawa, M., Hisanaga, S
- Journal Title
  
  J.Biol.Chem 280
  
  Pages: 31522-31529
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Tau-positive fine granules in the cerebral white matter : a novel finding exclusive to parkinsonism-dementia complex of Guam among the tauopathies2005
- Author(s)
  Yamazaki, M., Hasegawa, M., Mori, O., et al.
- Journal Title
  
  J.Neuropathol.Exp.Neurol 64
  
  Pages: 839-846
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Ubiquitination of alpha-synuclein.2005
- Author(s)
  Nonaka T, Iwatsubo T, Hasegawa M
- Journal Title
  
  Biochemistry 44
  
  Pages: 361-368
- Data Source
  KAKENHI-PROJECT-16015337
[Journal Article] Tau-positive fine granules in the cerebral white matter : a novel finding exclusive to parkinsonism-dementia complex of Guam among the tauopathies2005
- Author(s)
  Yamazaki, M., Hasegawa, M., Mori, O., et al.
- Journal Title
  
  J.Neuropathol.Exp.Neurol 64
  
  Pages: 839-846
- Data Source
  KAKENHI-PROJECT-17025052
[Journal Article] Four-repeat tau-positive Pick body-like inclusions are distinct from classic Pick bodies.2005
- Author(s)
  Motoi, Y., Hasegawa, M., Mizumo, Y., Mori, H
- Journal Title
  
  Acta Neuropathol.(Berl) 110
  
  Pages: 431-33
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.2005
- Author(s)
  Ikeda, M., Shoji, M., Kawarai, T, Hasegawa, M., et al.
- Journal Title
  
  Am.J.Pathol 166
  
  Pages: 521-531
- Data Source
  KAKENHI-PROJECT-17025052
[Journal Article] Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins2005
- Author(s)
  Taniguchi, S., Suzuki, N., Goedert, M., Hasegawa, M.
- Journal Title
  
  J.Biol.Chem 280
  
  Pages: 7614-7623
- Data Source
  KAKENHI-PROJECT-17025052
[Journal Article] Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.2005
- Author(s)
  Ikeda, M., Shoji, M., Kawarai, T, Hasegawa, M., et al.
- Journal Title
  
  Am.J.Pathol 166
  
  Pages: 521-531
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Unique tauopathy in Fukuyama-type congenital muscular dystrophy.2005
- Author(s)
  Saito Y, Motoyoshi Y, Kashima T, Izumiyama-Shimoharma M, Toda T, Nakano I, Hasegawa M, Murayama S.
- Journal Title
  
  J Neuropathol Exp Neurol 64
  
  Pages: 1118-1126
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Tau-positive fine granules in the cerebral white matter : a novel finding exclusive to parkinsonism-dementia complex of Guam among the tauopathies2005
- Author(s)
  Yamazaki, M., Hasegawa, M., Mori, O.et al.
- Journal Title
  
  J. Neuropathol. Exp. Neurol 64
  
  Pages: 839-46
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.2005
- Author(s)
  Ikeda M, Hasegawa M, Westaway D, et al.
- Journal Title
  
  Am J Pathol 166
  
  Pages: 521-531
- Data Source
  KAKENHI-PROJECT-16015337
[Journal Article] Phosphorylation of FTDP-17 mutant TAU by cyclin-dependent kinase 5 complexed with p35, p25, or p39.2005
- Author(s)
  Sakaue, F., Saito, T., Hasegawa, M., Hisanaga, S
- Journal Title
  
  J. Biol. Chem 280
  
  Pages: 31522-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Four-repeat tau-positive Pick body-like inclusions are distinct from classic Pick bodies.2005
- Author(s)
  Motoi, Y., Hasegawa, M., Yasuda, M., Mizuno, Y., Mori, H
- Journal Title
  
  Acta Neuropathol. (Berl) 110
  
  Pages: 431-433
- Data Source
  KAKENHI-PROJECT-17025052
[Journal Article] Phosphorylation of FTDP-17 mutant TAU by cyclin-dependent kinase 5 complexed with p35, p25, or p39.2005
- Author(s)
  Sakaue, F., Saito, T., Hasegawa, M., Hisanaga, S
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 31522-31529
- Data Source
  KAKENHI-PROJECT-17025052
[Journal Article] Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins.2005
- Author(s)
  Taniguchi S, Suzuki N, Masuda M, Hisanaga SI, Iwatsubo T, Goedert M, Hasegawa M
- Journal Title
  
  J Biol Chem 280
  
  Pages: 7614-7623
- Data Source
  KAKENHI-PROJECT-16015337
[Journal Article] Unique tauopathy in Fukuyama-type congenital muscular dystrophy.2005
- Author(s)
  Saito, Y., N, Hasegawa, M., Murayama, S.
- Journal Title
  
  J.Neuropathol.Exp.Neurol 64
  
  Pages: 839-846
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Four-repeat tau-positive Pick body-like inclusions are distinct from classic Pick bodies.2005
- Author(s)
  Motoi Y, Iwamoto H, Itaya M, Kobayashi T, Hasegawa M, Yasuda M, Mizuno Y, Mori H.
- Journal Title
  
  Acta Neuropathol (Berl) 110
  
  Pages: 431-433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Phosphorylation of FTDP-17 mutant TAU by cyclin-dependent kinase 5 complexed with p35, p25, or p39.2005
- Author(s)
  Sakaue, F., Saito, T., Sato, Y., Asada, A., Ishiguro, K., Hasegawa, M., Hisanaga, S.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 31522-31529
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Inhibition of heparin-induced tau filament formation by phenothiazines, polvphenols and porphyrins.2005
- Author(s)
  Taniguchi S, Suzuki N, Masuda M, Hisanaga S, Iwatsubo T, Goedert M, Hasegawa M
- Journal Title
  
  J Biol Chem 280
  
  Pages: 7614-7623
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Ubiquitination of alpha-synuclein.2005
- Author(s)
  Nonaka T, Iwatsubo T, Hasegawa M
- Journal Title
  
  Biochemistry 44
  
  Pages: 361-368
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Tau-positive fine granules in the cerebral white matter : a novel finding exclusive to parkinsonism-dementia complex of Guam among the tauopathies.2005
- Author(s)
  Yamazaki M, Hasegawa M, Mori O, Murayama S, Tsuchiya K, Ikeda K, Chen K-M, Katayama Y, Oyanagi K
- Journal Title
  
  J Neuropathol Exp Neurol 64
  
  Pages: 839-846
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Four-repeat tau-positive Pick body-like inclusions are distinct from classic Pick bodies.2005
- Author(s)
  Motoi, Y., Hasegawa, M., Yasuda, M., Mizuno, Y., Mori, H
- Journal Title
  
  Acta Neuropathol.(Berl) 110
  
  Pages: 431-433
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.2005
- Author(s)
  Ikeda, M., Shoji, M., Kawatai, T, Hasegawa.M.et al.
- Journal Title
  
  Am. J. Pathol 166
  
  Pages: 521-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.2005
- Author(s)
  Ikeda, M., Shoji, M., Kawarai, T., Kawarabayashi, T., Matsubara, E., Murakami, T., Sasaki, A., Tomidokoro, Y., Ikarashi, Y., Kuribara, H., Ishiguro, K., Hasegawa, M., Yen, S.H., Chishti, M.A., Harigaya, Y., Abe, K., Okamoto, K., St George-Hyslop.P., Westaway, D.
- Journal Title
  
  Am J Pathol 166
  
  Pages: 521-531
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Ubiquitination of alpha-synuclein.2005
- Author(s)
  Nonaka, T., Iwatsubo, T., Hasegawa, M.
- Journal Title
  
  Biochemistry 44
  
  Pages: 361-368
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins2005
- Author(s)
  Taniguchi, S., Suzuki, N., Goedert, M., Hasegawa, M.
- Journal Title
  
  J.Biol.Chem 280
  
  Pages: 7614-7623
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Ubiquitination of alpha-synuclein.2005
- Author(s)
  Nonaka T, Iwatsubo T, Hasegawa M:
- Journal Title
  
  Biochemistry 44
  
  Pages: 361-368
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins2005
- Author(s)
  Taniguchi, S., Suzuki, N...., Goedert, M., Hasegawa, M.
- Journal Title
  
  J. Biol. Chem 280
  
  Pages: 7614-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein.2004
- Author(s)
  Taniguchi S, McDonagh AM, Pickering-Brown SA, Umeda Y, Iwatsubo T, Hasegawa M, Mann DMA
- Journal Title
  
  Neuropathol Appl Neurobiol 30
  
  Pages: 1-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Stress-and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD95 by activation of SAPK3/p38g and ERK1/ERK2.2004
- Author(s)
  Sabio G, Hasegawa M, Goedert M, Garner C, Cuenda A, et al.
- Journal Title
  
  Biochem J 380
  
  Pages: 19-30
- Data Source
  KAKENHI-PROJECT-16015337
[Journal Article] Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies.2004
- Author(s)
  Umeda Y, Taniguchi S, Arima K, Piao Y-S, Mann D, Hasegawa M, et al.
- Journal Title
  
  Neurosci.Lett 359
  
  Pages: 151-154
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Identification of amino-terminal cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration.2004
- Author(s)
  Arai T, Ikeda K, Akiyama H, Nonaka T, Hasegawa M et al.
- Journal Title
  
  Ann Neurol 55
  
  Pages: 72-79
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Stress-and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD95 by activation of SAPK3/p38g and ERKI1/ERK2.2004
- Author(s)
  Sabio G, Hasegawa M, Goedert M, Garner C, Cuenda A et al.
- Journal Title
  
  Biochem J 380
  
  Pages: 19-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Frontopemporal dementia with Pick-type histology associated with Q336R mutation in tau gene.2004
- Author(s)
  Pickering-Brown SM, Hasegawa M, Mann DMA et al.
- Journal Title
  
  Brain 127
  
  Pages: 1415-1426
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Frontopemporal dementia with Pick-type histology associated with Q336R mutation in tau gene.2004
- Author(s)
  Pickering-Brown SM, Hasegawa M, Hutton M, Mann DMA, et al.
- Journal Title
  
  Brain 127
  
  Pages: 1415-1426
- Data Source
  KAKENHI-PROJECT-16015337
[Journal Article] Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.2004
- Author(s)
  Nishie M, Mori F, Hasegawa M, Takahashi H, Wakabayashi K, et al.
- Journal Title
  
  Acta Neuropathol 107
  
  Pages: 292-298
- Data Source
  KAKENHI-PROJECT-16015337
[Journal Article] The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein.2004
- Author(s)
  Tniguchi S, McDonagh AM, Hasegawa M et al.
- Journal Title
  
  Neuropathol Appl Neurobiol 30
  
  Pages: 1-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies.2004
- Author(s)
  Umeda Y, Taniguchi S, Arima K, Piao Y-S, Mann D, Hasegawa M et al.
- Journal Title
  
  Neurosci. Lett 359
  
  Pages: 151-154
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2.2004
- Author(s)
  Sabio G, Reuver S, Feijoo C, Hasegawa M, Thomas GM, Centeno F, Kuhlendahl S Leal-Ortiz S, Goedert M, Garner C, Cuenda A
- Journal Title
  
  Biochem J 380
  
  Pages: 19-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.2004
- Author(s)
  Nishie M, Mori F, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K
- Journal Title
  
  Acta Neuropathol 107
  
  Pages: 292-298
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Mann DMA : Frontopemporal dementia with Pick-type histology associated with Q336R mutation in tam gene.2004
- Author(s)
  Pickering-Brown SM, Baker M, Nonaka T, Ikeda K, Sharma S, Mackenzie J, Simpson SA, Moore JW, Snowden JS, de Silva R, Revesz T, Hasegawa M, Hutton M
- Journal Title
  
  Brain 127
  
  Pages: 1415-1426
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Frontopemporal dementia with Pick-type histology associated with Q336R mutation in tau gene.2004
- Author(s)
  Pickering-Brown SM, Hasegawa M, Hutton M, Mann DMA, et al.
- Journal Title
  
  Brain 127
  
  Pages: 1415-1426
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Phosphorylated alpha-synuclein in normal mouse brain.2004
- Author(s)
  Hirai Y, Fujita SC, Iwatsubo T, Hasegawa M
- Journal Title
  
  FEBS Left 572
  
  Pages: 227-232
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies.2004
- Author(s)
  Umeda Y, Taniguchi S, Arima K, Piao Y-S, Takahashi H, Iwatsubo T, Mann D, Hasegawa M
- Journal Title
  
  Neurosci.Lett 359
  
  Pages: 151-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Phosphorylated alpha-synuclein in normal mouse brain.2004
- Author(s)
  Hirai Y, Fujita SC, Iwatsubo T, Hasegawa M
- Journal Title
  
  FEBS Lett 572
  
  Pages: 227-232
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.2004
- Author(s)
  Nishie M, Mori F, Hasegawa M, Takahashi H, Wakabayashi K, et al.
- Journal Title
  
  Acta Neuropathol 107
  
  Pages: 292-298
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies.2004
- Author(s)
  Umeda Y, Taniguchi S, Arima K, Piao Y-S, Mann D, Hasegawa M, et al.
- Journal Title
  
  Neurosci.Lett 359
  
  Pages: 151-154
- Data Source
  KAKENHI-PROJECT-16015337
[Journal Article] Identification of amino-terminal cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration.2004
- Author(s)
  Arai T, Ikeda K, Akiyama H, Nonaka T, Hasegawa M, Ishiguro K, Iritani S, Tsuchiya K, Iseki E, Yagishita S, Oda T, Mochizuki A
- Journal Title
  
  Ann Neurol 55
  
  Pages: 72-79
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD95 by activation of SAPK3/p38g and ERK1/ERK2.2004
- Author(s)
  Sabio G, Hasegawa M, Goedert M, Garner C, Cuenda A, et al.
- Journal Title
  
  Biochem J 380
  
  Pages: 19-30
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia patients with multiple system atrophy.2004
- Author(s)
  Nishie M, Mori F, Hasegawa M, Takehashi H, Wakabayashi K et al.
- Journal Title
  
  Acta Neuropathol 107
  
  Pages: 292-298
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Phosphorylated alpha-synuclein in normal mouse brain.2004
- Author(s)
  Hirai Y, Fujita SC, Iwatsubo T, Hasegawa M
- Journal Title
  
  FEBS Lett 572
  
  Pages: 227-232
- Data Source
  KAKENHI-PROJECT-16015337
[Journal Article] Accumulation of phosphorylated alpha-synuclein in aging human brain.2003
- Author(s)
  Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S
- Journal Title
  
  J Neuropathol Exp Neurol 62
  
  Pages: 644-654
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] alpha-synuclein accumulates in purkinje cells in Lewy body disease but not in multiple system atrophy.2003
- Author(s)
  Mori F, Piao Y-S, Hayashi S, Fujiwara H, Hasegawa M et al.
- Journal Title
  
  J Neuropathol Exp Neurol 62
  
  Pages: 812-819
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62.2003
- Author(s)
  Arai T, Nonaka T, Hasegawa M et al.
- Journal Title
  
  Neurosci Lett 342
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique pathology2003
- Author(s)
  Kobayashi T, Ota S, Tanaka K, Ito Y, Hasegawa M et al.
- Journal Title
  
  Ann Neurol 53
  
  Pages: 133-137
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] alpha-synuclein accumulates in purkinje cells in Lewy body disease but not in multiple system atrophy.2003
- Author(s)
  Mori F, Piao Y-S, Hayashi S, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K
- Journal Title
  
  J Neuropathol Exp Neurol 62
  
  Pages: 812-819
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62.2003
- Author(s)
  Arai T, Nonaka T, Hasegawa M, Akiyama H, Yoshida M, Hashizume Y, Tsuchiya K, Oda T, Ikeda K
- Journal Title
  
  Neurosci Lett 342
  
  Pages: 41-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau apthology.2003
- Author(s)
  Kobayashi T, Ota S, Tanaka K, Ito Y, Hasegawa M, Umeda Y, Motoi Y, Takanashi M, Yasuhara M, Anno M, Mizuno Y, Mori H
- Journal Title
  
  Ann Neurol 53
  
  Pages: 133-137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] 1. Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila2003
- Author(s)
  Takahashi M, Kanuka H, Fujiwara H, Hasegawa M et al.
- Journal Title
  
  Neurosci Lett 336
  
  Pages: 155-158
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila2003
- Author(s)
  Takahashi M, Kanuka H, Fujiwara H, Hasegawa M, Miura M, Iwatsubo T
- Journal Title
  
  Neurosci Lett 336
  
  Pages: 155-158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Accumulation of phosphorylated alpha-synuclein in aging human brain.2003
- Author(s)
  Saito Y, Kawashima A, Ruberu NN, Hasegawa M et al.
- Journal Title
  
  J Neuropathol Exp Neurol 62
  
  Pages: 644-645
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300119
[Journal Article] Phosphorylated a-synuclein is ubiquitinated in α-synucleinopathy lesions.2002
- Author(s)
  Hasegawa M
- Journal Title
  
  J Biol Chem 277
  
  Pages: 49071-49076
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210006
[Journal Article] Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions.2002
- Author(s)
  Hasegawa M
- Journal Title
  
  J Biol Chem 277
  
  Pages: 49071-49076
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210006
[Journal Article] Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy.
- Author(s)
  Arai T, Hasegawa M, 他10名
- Journal Title
  
  Neuropathology (印刷中)
- NAID
  10029320452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591024
[Patent] 新規タウオパチーモデルマウスの作製方法2013
- Inventor(s)
  鈴掛雅美、長谷川成人
- Industrial Property Rights Holder
  京都医学総合研究所
- Filing Date
  2013-12-26
- Data Source
  KAKENHI-PROJECT-23240050
[Patent] 新規タウオパチーモデルマウスの作製方法2013
- Inventor(s)
  鈴掛雅美、長谷川成人
- Industrial Property Rights Holder
  東京都医学総合研究所
- Filing Date
  2013-12-26
- Overseas
- Data Source
  KAKENHI-PROJECT-23240050
[Patent] タンパク質重合体の重合核となりうるタンパク質又はその重合体が導入された細胞及びその製造法2011
- Inventor(s)
  野中隆、渡辺小百合、増田雅美、長谷川成人
- Industrial Property Rights Holder
  東京都医学総合研究所
- Acquisition Date
  2011-10-05
- Overseas
- Data Source
  KAKENHI-PROJECT-23240050
[Patent] 神経変性疾患関連タンパク質の不溶性凝集体の増幅方法2011
- Inventor(s)
  野中隆、増田雅美、山下万喜子、秋山治彦、長谷川成人
- Industrial Property Rights Holder
  東京都医学総合研究所
- Filing Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-23240050
[Patent] 神経変性疾患関連タンパク質の不溶性凝集体の増幅方法2011
- Inventor(s)
  野中隆、増田雅美、山下万喜子、秋山治彦、長谷川成人
- Industrial Property Rights Holder
  東京都医学総合研究所
- Filing Date
  2011-11-18
- Overseas
- Data Source
  KAKENHI-PROJECT-23240050
[Patent] 遺伝子変異を用いた筋萎縮性側索硬化症の予測法2008
- Inventor(s)
  糸川昌成、長谷川成人、他
- Industrial Property Rights Holder
  医学研究機構
- Industrial Property Number
  2008-095035
- Filing Date
  2008-04-01
- Data Source
  KAKENHI-PROJECT-18300117
[Patent] TDP-43蓄積細胞モデル2008
- Inventor(s)
  野中隆、新井哲明、秋山治彦、長谷川成人
- Industrial Property Rights Holder
  財団法人東京都医学研究機構
- Industrial Property Number
  2008-101899
- Filing Date
  2008-04-09
- Data Source
  KAKENHI-PROJECT-18300117
[Patent] 遺伝子変異を用いた筋萎縮性側索硬化症の予測法2008
- Inventor(s)
  糸川昌成、新井誠、長谷川成人、野中隆, 秋山治彦、新井哲明
- Industrial Property Rights Holder
  財団法人東京都医学研究機構
- Industrial Property Number
  2008-095035
- Filing Date
  2008-04-01
- Data Source
  KAKENHI-PROJECT-18300117
[Patent] TDP-43凝集物に特異的に結合する抗体2007
- Inventor(s)
  長谷川成人, 新井哲明, 他
- Industrial Property Rights Holder
  医学研究機構
- Industrial Property Number
  2007-178583
- Filing Date
  2007-07-07
- Data Source
  KAKENHI-PROJECT-19591024
[Patent] TDP-43凝集物に特異的に結合する抗体2007
- Inventor(s)
  長谷川成人、新井哲明、野中隆、亀谷富由樹、秋山治彦
- Industrial Property Rights Holder
  財団法人東京都医学研究機構
- Industrial Property Number
  2007-178583
- Filing Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-18300117
[Patent] TDP-43凝集物に特異的に結合する抗体2007
- Inventor(s)
  長谷川成人、新井哲明、他
- Industrial Property Rights Holder
  医学研究機
- Industrial Property Number
  2007-178583
- Filing Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-19591024
[Patent] TDP-43凝集物に特異的に結合する抗体2007
- Inventor(s)
  長谷川成人、他
- Industrial Property Rights Holder
  医学研究機構
- Industrial Property Number
  2007-178583
- Filing Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-18300117
[Patent] 神経変性疾患治療用物質のスクリーニング方法2006
- Inventor(s)
  野中隆、増田雅美、長谷川成人
- Industrial Property Rights Holder
  財団法人東京都医学研究機構
- Industrial Property Number
  2006-030530
- Filing Date
  2006-02-08
- Data Source
  KAKENHI-PROJECT-18300117
[Patent] 遺伝子変異を用いた筋萎縮性側索硬化症の予測法
- Inventor(s)
  糸川昌成、長谷川成人、他
- Industrial Property Rights Holder
  医学研究機構
- Data Source
  KAKENHI-PROJECT-18023042
[Patent] TDP-43凝集物に特異に結合する抗体
- Inventor(s)
  長谷川成人、他
- Industrial Property Rights Holder
  医学研究機構
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] DSタウを用いたタウ伝播における慢性脳低灌流の影響の解明2022
- Author(s)
  武倉　アブドグプル、鈴掛　雅美、篠原　充、渡邉　淳、新堂　晃大、冨本秀和、長谷川　成人、里　直行
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02844
[Presentation] α-Synuclein Propagation in Parkinson’s Disease and Multiple System Atrophy.2018
- Author(s)
  Hasegawa M
- Organizer
  Basic Science Summer School MDS/Education/Conferences & Courses. 2018. 8. 3. Osaka.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] Prion-like propagation of pathological tau in neurodegenerative diseases.2018
- Author(s)
  Hasegawa M
- Organizer
  ICN2018 2018. 9.24, Tokyo.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] Prion-like propagation of pathological tau in neurodegenerative diseases.2018
- Author(s)
  Hasegawa M
- Organizer
  Japan-UK Neuroscience Symposium, 2019. 2. 10, Chiba.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] αSynuclein in Parkinson’s disease and related disorders.2018
- Author(s)
  Hasegawa M
- Organizer
  WCP2018 KYOTO (18th World Congress of Basic and Clinical Pharmacology), Kyoto. 2018. 7. 5.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] Mutations in the PFN1 gene induce degenerative changes through aggregation of both mutant PFN1 and TDP-43.2016
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Organizer
  第14回医学研国際シンポジウム
- Place of Presentation
  東京都医学総合研究所 (東京都世田谷区)
- Year and Date
  2016-06-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] ALSの原因となるプロフィリン1変異は機能獲得によりTDP-43の蓄積を誘起する2016
- Author(s)
  田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
- Organizer
  H27年度　ALS病態解明班　成果報告会
- Place of Presentation
  都市センターホテル(東京都千代田区)
- Year and Date
  2016-01-26
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Progranulin overexpression decrease levels of the matured form of cathepsin D due to enhancement of lysosomal acidificaition.2016
- Author(s)
  Tanaka Y, Suzuki G, Hosokawa M, Kametani F, Hasegawa M, Nishihara M.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Progranulin overexpression decreases levels of the matured form of cathepsin D due to enhancement of lysosomal acidification2016
- Author(s)
  Tanaka Y, Suzuki G, Hosokawa M, Kametani F, Hasegawa M, Nishihara M
- Organizer
  第38回　日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-23228004
[Presentation] タウオパチーの生化学2015
- Author(s)
  長谷川成人
- Organizer
  第9回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  品川プリンス（東京都品川区）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-221S0003
[Presentation] タウオパチーの生化学.2015
- Author(s)
  長谷川成人
- Organizer
  第9回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  品川プリンホテル（東京都品川区）
- Year and Date
  2015-10-16
- Invited
- Data Source
  KAKENHI-PROJECT-15H02356
[Presentation] タンパク質の伝播から考える神経変性疾患治療の可能性2015
- Author(s)
  長谷川成人
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-11-28
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] Gain-of-function Profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause intracellular TDP-43 aggregation.2015
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Organizer
  Brain Protein Aging and Dementia Control, 1st International Symposium 2015
- Place of Presentation
  野依記念学術交流館(愛知県名古屋市)
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] 脳タンパク質老化と認知症制御2015
- Author(s)
  長谷川成人
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-26
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] タンパク質の伝播から考える神経変性疾患治療の可能性2015
- Author(s)
  長谷川成人
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  国際会議場（愛知県名古屋市）
- Year and Date
  2015-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-15H02356
[Presentation] グラニュリン変異脳における神経変性疾患関連タンパク質の重複蓄積2015
- Author(s)
  細川雅人，新井哲明，近藤ひろみ，長谷川成人，秋山治彦
- Organizer
  第34回日本認知症学会
- Place of Presentation
  リンクステーション青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] 神経変性疾患における異常タンパク質の伝播.2015
- Author(s)
  長谷川成人
- Organizer
  第20回日本神経感染症学会
- Place of Presentation
  ホテルメルパルク長野（長野県長野市）
- Year and Date
  2015-10-23
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] シンポジウム16「精神医学における各種仮説を問う」アルツハイマー病のタウ仮説.2015
- Author(s)
  長谷川成人
- Organizer
  第111回日本精神神経学会学術総会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-06-05
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] Mutations in the PFN1 gene induce degenerative changes through aggregation of both mutant PFN1 and TDP-43.2015
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Organizer
  Neuroscience 2015, SfN's 45th annual meeting
- Place of Presentation
  シカゴ(米国)
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] アルツハイマー病のタウ仮説.2015
- Author(s)
  長谷川成人
- Organizer
  第111回日本精神神経学会学術総会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-06-05
- Invited
- Data Source
  KAKENHI-PROJECT-15H02356
[Presentation] 神経変性疾患における異常タンパク質の伝播.2015
- Author(s)
  長谷川成人
- Organizer
  第２０回日本神経感染症学会
- Place of Presentation
  ホテルメルパルク長野（長野県長野市）
- Year and Date
  2015-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-15H02356
[Presentation] 脳タンパク質老化と認知症制御.2015
- Author(s)
  長谷川成人
- Organizer
  第15回日本蛋白質科学会年会.
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-26
- Invited
- Data Source
  KAKENHI-PROJECT-15H02356
[Presentation] ALSの原因となるプロフィリン１変異は機能獲得によりTDP-43の凝集を誘起する2015
- Author(s)
  田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
- Organizer
  認知症研究を知る若手研究者の集まり 2015
- Place of Presentation
  ニューサンピア高崎(群馬県高崎市)
- Year and Date
  2015-08-02
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] タウオパチーの生化学.2015
- Author(s)
  長谷川成人
- Organizer
  第9回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  品川プリンスホテル（東京都品川区）
- Year and Date
  2015-10-16
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] ALSの原因となるプロフィリン1変異はTDP-43の凝集を誘起する2015
- Author(s)
  田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
- Organizer
  第41回日本認知症学会
- Place of Presentation
  リンクステーションホテル青森(青森県青森市)
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Molecular analyses of pathological tau in tauopathy brains.2015
- Author(s)
  Hasegawa M
- Organizer
  Brain Protein Aging and Dementia Control. 1st International Symposium. Molecular bases of brain protein aging.
- Place of Presentation
  名古屋大学（愛知県名古屋市）
- Year and Date
  2015-10-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02356
[Presentation] 3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease. International symposium2014
- Author(s)
  Hasegawa M, Dan A, Watanabe S, Kondo H, Akiyama H, Mann DM, Saito Y, Murayama S
- Organizer
  New Frontier of Molecular Neuropathology 2014
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2014-03-17
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 神経変性疾患の病態進行とプリオン仮説2014
- Author(s)
  長谷川成人
- Organizer
  川棚神経科学の会, 特別講演3
- Place of Presentation
  長崎川棚医療センター（長崎県・川棚町）
- Year and Date
  2014-12-06
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] αシヌクレイン.2014
- Author(s)
  長谷川成人
- Organizer
  第８回パーキンソン病・運動障害疾患コングレス２０１４
- Place of Presentation
  京都オークラホテル（京都府・京都市）
- Year and Date
  2014-10-04
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] 神経変性疾患における細胞内異常タンパク質の伝播.2014
- Author(s)
  長谷川成人
- Organizer
  第2回アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京都・千代田区）
- Year and Date
  2014-08-22
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] Molecular Mechanisms underlying Parkinson Disease2014
- Author(s)
  長谷川成人
- Organizer
  第37回　日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-12
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110738
[Presentation] プログラニュリンの減少はタウのリン酸化を亢進させる2014
- Author(s)
  細川雅人、新井哲明、増田－鈴掛雅美、近藤ひろみ、松脇貴志、西原真杉、長谷川成人、秋山治彦
- Organizer
  第33回日本認知症学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-30
- Data Source
  KAKENHI-PROJECT-23228004
[Presentation] タウP301L変異が確認されたFTDP-17の1例2014
- Author(s)
  鈴木寿臣，女屋光基，野島照雄，冨永格，織田辰郎，三村將，小林智則，長谷川成人，秋山治彦
- Organizer
  第55回日本神経病理学会
- Place of Presentation
  一橋講堂（東京都）
- Year and Date
  2014-06-07
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] 外傷性脳損傷の脳における神経変性疾患関連たんぱく質の凝集体分布の検討2014
- Author(s)
  東　晋二，羽賀千恵，河上緒，長谷川成人，大島健一，新里和弘，女屋光基，秋山治彦
- Organizer
  第55回日本神経病理学会
- Place of Presentation
  一橋講堂（東京都）
- Year and Date
  2014-06-06
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] AD脳に蓄積するタウの解析2014
- Author(s)
  長谷川成人，近藤ひろみ，齊藤祐子，初田裕幸，村山繁雄，秋山治彦
- Organizer
  第55回日本神経病理学会
- Place of Presentation
  一橋講堂（東京都）
- Year and Date
  2014-06-06
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] 神経変性疾患における細胞内異常タンパク質の伝播2014
- Author(s)
  長谷川成人
- Organizer
  第2回　日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京
- Year and Date
  2014-08-22
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110738
[Presentation] Prion-like properties of pathological proteins from diseased brains.2014
- Author(s)
  Hasegawa M
- Organizer
  Brain Conference 2014, Symposium 4「Pathological propagation in neurodegenerative diseases」
- Place of Presentation
  Seoul, Korea
- Year and Date
  2014-11-06
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] 「タウは認知症治療標的として魅力的か？」2014
- Author(s)
  長谷川成人
- Organizer
  第33回日本認知症学会学術集会シンポジウム
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-11-30
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] Pathological alpha-synuclein spreading explains the disease progression.2014
- Author(s)
  Hasegawa M
- Organizer
  Neuroscience 2014. Joint Symposium of the Japan Neuroscience Society and the Korean Society of Brain and Neuroscience: Molecular Mechanisms underlying Parkinson Disease.
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-12
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] Prion-like features in alpha-synucleinopathies.2014
- Author(s)
  Hasegawa M
- Organizer
  XVIIIth International Congress of Neuropathology 2014. W3: Prion-like mechanisms in neurodegenerative disorders.
- Place of Presentation
  Rio de Janeiro, Brazil
- Year and Date
  2014-09-15
- Invited
- Data Source
  KAKENHI-PLANNED-26117005
[Presentation] αシヌクレインの伝播について2014
- Author(s)
  長谷川成人
- Organizer
  第8回　進行期パーキンソン病研究会
- Place of Presentation
  名古屋マリオットアソシアホテル
- Year and Date
  2014-05-30
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110738
[Presentation] タウトランスジェニックマウスにおいてプログラニュリンの減少はタウのリン酸化に影響を与える2014
- Author(s)
  細川雅人、新井哲明、鈴掛雅美、近藤ひろみ、松脇貴志、西原真杉、長谷川成人、秋山治彦
- Organizer
  第61回日本実験動物学会
- Place of Presentation
  札幌
- Year and Date
  2014-05-15
- Data Source
  KAKENHI-PROJECT-23228004
[Presentation] Insoluble TDP-43 prepared from diseased brains has prion-like properties2013
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann D, Akiyama H, Hasegawa M
- Organizer
  Alzheimer's Association International Conference 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Insoluble TDP-43 prepared from diseased brains has prion-like properties2013
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H and Hasegawa M
- Organizer
  Alzheimer's Association International Conference (AAIC2013)
- Place of Presentation
  Boston, USA
- Year and Date
  2013-07-18
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] Prion-like spreading of pathological alpha-synuclein in brain2013
- Author(s)
  Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H and Hasegawa M
- Organizer
  The 11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Year and Date
  2013-03-09
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] Insoluble TDP-43 prepared from diseased brains has prion-like properties.2013
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann D, Akiyama H, Hasegawa M
- Organizer
  lzheimer’s Association International Conference 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Prion-like properties of pathological TDP-43 aggregates in diseased brains2013
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Yoshida M, Murayama S, Mann D, Akiyama H and Hasegawa M
- Organizer
  The 11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Year and Date
  2013-03-07
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] レビー小体型認知症患者脳不溶性画分の脳内接種は野生型マウス脳にレビー小体様病理を形成させる2013
- Author(s)
  鈴掛雅美, 野中隆, 細川雅人, 笈川貴行, 新井哲明, 秋山治彦, Mann D, 長谷川成人
- Organizer
  第54回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Year and Date
  2013-04-25
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] tangle-predominant dementiaの側座核におけ病理学的検討2013
- Author(s)
  河上緒, 長谷川成人, 新井哲明, 青木直哉, 勝瀬大海, 東晋二, 大島健一, 新里和弘, 近藤ひろみ, 羽賀千恵, 下村洋子, 山下万貴子, 鈴木京子, 平安良雄, 秋山治彦
- Organizer
  第54回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Year and Date
  2013-04-25
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Tau pathology in the parahippocampal region is related to delusion in the elderly : neuropathological study of two autopsy cases2013
- Author(s)
  Arai T, Kawakami I, Mizukami K, Ikeda K, Oshima K, Niizato K, Kobayashi Z, Hosokawa M, Nonaka T, Hasegawa M, Akiyama H, Asada T
- Organizer
  Alzheimer's Association International Conference 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Prion-like properties of pathological TDP-43 aggregates in diseased brains2013
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Yoshida M, Murayama S, Mann D, Akiyama H, Hasegawa M
- Organizer
  The 11th International Conference on Alzheimer's and Parkinson's disease
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Tau pathology in the parahippocampal region is related to delusion in the elderly: neuropathological study of two autopsy cases.2013
- Author(s)
  Arai T, Kawakami I, Mizukami K, Ikeda K, Oshima K, Niizato K, Kobayashi Z, Hosokawa M, Nonaka T, Hasegawa M, Akiyama H, Asada T
- Organizer
  Alzheimer’s Association International Conference 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Prion-like properties of pathological TDP-43 in diseased brains2013
- Author(s)
  野中隆, 鈴掛雅美, 新井哲明, 赤津裕泰, 小尾智一, 吉田眞理, 村山繁雄, Mann D, 秋山治彦, 長谷川成人
- Organizer
  第54回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Year and Date
  2013-04-25
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 「蛋白癌」としてのアルツハイマー病2012
- Author(s)
  長谷川成人
- Organizer
  北海道大学薬学部・大学院薬学研究院神経病理・病態生化学(IBL)シンポジウム
- Place of Presentation
  札幌(招待講演)
- Year and Date
  2012-02-23
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] レビー小体とαシヌクレイン2012
- Author(s)
  長谷川成人
- Organizer
  第６回　レビー小体型認知症研究会 (レビー小体発見１００周年記念大会)
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] シード依存的な細胞内TDP-43蓄積による細胞死の誘導2012
- Author(s)
  野中隆, 鈴掛(増田)雅美, 新井哲明, 吉田眞理, 村山繁雄, Mann David, 秋山治彦, 長谷川成人
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Prion-like Spreading of Pathological a-synuclein in Brain.2012
- Author(s)
  Hasegawa M
- Organizer
  The 17th Takeda Science Foundation Symposium
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 神経疾患における異常タンパク質のプロテオミクス解析.2012
- Author(s)
  長谷川成人
- Organizer
  日本プロテオーム学会2012年大会シンポジウムS５医学の最前線とプロテオミクス
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] Screening of the SOD1, TARDBP and FUS mutations and the pathological studies in Japanese cases with familial and sporadic amyotrophic lateral sclerosis2012
- Author(s)
  Arai T, Arai M, Itokawa M, Yoshida M, Tamaoka A, Kobayashi Z, Hosokawa M, Hasegawa M, Nonaka T, Tsuji H, Yamada M, Matsui M, Kaji R, Nakashima K, Kuwano R, Takahashi S, Asada T, Akiyama H
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2012-07-15
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Prion-like Spreading of Pathological a-synuclein in Brain.2012
- Author(s)
  Hasegawa M
- Organizer
  The 17th Takeda Science Foundation Symposium #8232;on Bioscience
- Place of Presentation
  大阪
- Year and Date
  2012-12-05
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 蛋白癌」としての神経変性疾患2012
- Author(s)
  長谷川成人
- Organizer
  第53回神経学会総会シンポジウム: 神経変性疾患の病態解明・その病態とバイオマーカーの開発を目指して
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 神経変性疾患は「蛋白癌」か？2012
- Author(s)
  長谷川成人
- Organizer
  名古屋大学グローバルCOEプログラム機能分子医学への神経疾患・腫瘍の融合拠点グローバルCOE第５回国内シンポジウム
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] Three autopsy cases of FTD-MND with progressive aphasia2012
- Author(s)
  Kawakami I, Higashi S, Aoki N, Niizto K, Ohshima K, Katsuse O, Togo T, Kobayashi Z, Hosokawa M, Tsuji H, Tamaoka A, Hasegawa M, Arai T, Tsuchiya K, Hirayasu Y, Akiyama H
- Organizer
  The 8^<th> International Conference on Frontotemporal Dementias
- Place of Presentation
  Manchester, UK
- Year and Date
  2012-09-15
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] FUS-immunopositive Inclusions and Compound Pick Bodies in Two Cases of Frontotemporal Lobar Degeneration with Motor Neuron Disease (FTLDMND).2012
- Author(s)
  Nakamoto F, Takao M, Ikemura M, Hayashi T, Ito S, Maeda D, SaitoY, Takahashi Y, Hasegawa M, Fukayama M, Tsuji S, Murayama S
- Organizer
  The 8th International Conference on Frontotemporal Dementias.
- Place of Presentation
  Manchester, UK.
- Data Source
  KAKENHI-PROJECT-221S0003
[Presentation] 「蛋白癌」としてのアルツハイマー病2012
- Author(s)
  長谷川成人
- Organizer
  北海道大学薬学部・大学院薬学研究院神経病理・病態生化学(IBL)シンポジウム
- Place of Presentation
  札幌(招待講演)
- Year and Date
  2012-02-23
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 神経変性疾患の分子病態機序2012
- Author(s)
  長谷川成人
- Organizer
  日本食品免疫学会2012年度大会 (JAFI2012) 「シンポジウム１」
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 異常タンパク分子から解明される神経変性疾患の新しい考え方2012
- Author(s)
  長谷川成人
- Organizer
  首都大学東京CRESTシンポジウム
- Place of Presentation
  東京(招待講演)
- Year and Date
  2012-02-03
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] ALSとTDP-43の生化学2012
- Author(s)
  長谷川成人, 野中隆, 辻浩史, 玉岡晃, 吉田眞理, 村山繁雄, Mann David, 新井哲明, 秋山治彦
- Organizer
  第53回日本神経病理学会総会学術集会
- Place of Presentation
  新潟
- Year and Date
  2012-06-30
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 神経変性疾患の分子病態機序2012
- Author(s)
  長谷川成人
- Organizer
  日本食品免疫学会2012年度大会 (JAFI2012) 「シンポジウム１」（
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 蓄積タンパク質の解析から発症機構の解明、治療法の開発へ2012
- Author(s)
  長谷川成人
- Organizer
  第7回　精神医療セミナー
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] TDP-43と関連疾患2012
- Author(s)
  長谷川成人
- Organizer
  第３１回日本認知症学会学術集会教育講演２「病因仮説再考」
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 神経変性疾患は「蛋白癌」か？2012
- Author(s)
  長谷川成人
- Organizer
  名古屋大学グローバルCOEプログラム機能分子医学への神経疾患・腫瘍の融合拠点グローバルCOE第５回国内シンポジウム
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 筋萎縮性側索硬化症：TDP-43の発見とその後2012
- Author(s)
  長谷川成人
- Organizer
  第53回神経病理学会総会シンポジウム２
- Place of Presentation
  新潟
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] Methylene blue reduced tau phosphorylation and aggregation in P301L transgenic mice2012
- Author(s)
  Hosokawa M, Arai T, Suzukake M, Yamashita M, Nonaka T, Hasegawa M, Kiyama H
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2012-07-15
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 神経疾患における異常タンパク質のプロテオミクス解析2012
- Author(s)
  長谷川成人
- Organizer
  日本プロテオーム学会2012年大会シンポジウムS５医学の最前線とプロテオミクス
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 「筋萎縮性側索硬化症：TDP-43の発見とその後」2012
- Author(s)
  長谷川成人
- Organizer
  第53回神経病理学会総会シンポジウム２
- Place of Presentation
  新潟
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 神経疾患と異常タンパク質2012
- Author(s)
  長谷川成人
- Organizer
  第13回北海道神経変性疾患治療研究会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 蓄積タンパク質の解析から発症機構の解明、治療法の開発へ. 国立精神・神経医療研究センター病院2012
- Author(s)
  長谷川成人
- Organizer
  第7回　精神医療セミナー
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] TDP-43と関連疾患2012
- Author(s)
  長谷川成人
- Organizer
  第３１回日本認知症学会学術集会教育講演２「病因仮説再考」
- Place of Presentation
  筑波
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] Intracellular seeding model reproduces characteristic features of affected neurons in TDP-43 proteinopathy2012
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Yoshida M, Murayama S, Man DMA, Akiyama H, Hasegawa M
- Organizer
  The 8^<th> International Conference on Frontotemporal Dementias
- Place of Presentation
  Manchester, UK
- Year and Date
  2012-09-15
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 神経疾患と異常タンパク質2012
- Author(s)
  長谷川成人
- Organizer
  第13回北海道神経変性疾患治療研究会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 異常タンパク分子から解明される神経変性疾患の新しい考え方2012
- Author(s)
  長谷川成人
- Organizer
  首都大学東京CRESTシンポジウム
- Place of Presentation
  東京(招待講演)
- Year and Date
  2012-02-03
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] レビー小体とαシヌクレイン2012
- Author(s)
  長谷川成人
- Organizer
  第６回　レビー小体型認知症研究会 (レビー小体発見１００周年記念大会)
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 「蛋白癌」としての神経変性疾患2012
- Author(s)
  長谷川成人
- Organizer
  第53回神経学会総会シンポジウム: 神経変性疾患の病態解明・その病態とバイオマーカーの開発を目指して
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] メチレンブルーによるリン酸化タウ蓄積抑制効果の検討2011
- Author(s)
  細川雅人, 新井哲明, 野中隆, 山下万貴子, 鈴掛雅美, 辻浩史, 長谷川成人,秋山治彦
- Organizer
  第30回日本認知症学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] TDP-43による運動ニューロン変性の分子病態2011
- Author(s)
  野中隆, 長谷川成人
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 神経変性疾患における蛋白癌仮説2011
- Author(s)
  長谷川成人, 他
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] ニューロピルに認められるＦＵＳ陽性微細顆粒について2011
- Author(s)
  青木直哉, 東晋二, 小林禅, 細川雅人, 近藤ひろみ, 羽賀千恵, 泉山洋子, 都甲崇, 勝瀬大海, 内門大丈, 鈴木京子, 新井哲明, 長谷川成人, 平安良雄, 秋山治彦
- Organizer
  第52回日本神経病理学会総会学術研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 神経変性疾患における細胞内異常タンパク質の伝播2011
- Author(s)
  長谷川成人
- Organizer
  第20回パーキンソン病治療研究会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 細胞内異常蛋白質の伝播の可能性2011
- Author(s)
  長谷川成人, 野中隆, 辻浩史, 増田雅美, 山下万貴子, 玉岡晃, Mann David, 村山繁雄, 新井哲明, 秋山治彦
- Organizer
  第30回日本認知症学会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 神経変性疾患の蛋白癌仮説2011
- Author(s)
  長谷川成人
- Organizer
  大阪大学蛋白質研究所セミナー「蛋白質の異常凝集の原理と制御」
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2011-04-27
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 神経変性疾患の蛋白癌仮説2011
- Author(s)
  長谷川成人
- Organizer
  大阪大学蛋白質研究所セミナー「蛋白質の異常凝集の原理と制御」
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2011-04-27
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] Histopathological analysis of progranulin knockout mice2011
- Author(s)
  Arai T, Matsuwaki T, Hasegawa M, Akiyama H, Nonaka T, Hosokawa M, Takahashi S, Mizukami K, Asada T, Nishihara M
- Organizer
  Alzheimer's Association International Conference 2011
- Place of Presentation
  Paris, France
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 高齢者ブレインバンクを用いたSeed,aggregation,propagation仮説の検証2011
- Author(s)
  長谷川成人, 他
- Organizer
  包括脳ネットワーク支援による融合的脳研究の展開
- Place of Presentation
  神戸(招待講演)
- Year and Date
  2011-08-23
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice2011
- Author(s)
  Hosokawa H, Arai T, Nonaka T, Yamashita M, Suzukake M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Quantitative determination of TDP-43 in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and other neurodegenerative disorders2011
- Author(s)
  Hosokawa M, Arai T, Nonaka T, Yamashita M, Tsuji H, Hasegawa M, Akiyama H
- Organizer
  Alzheimer's Association International Conference 2011
- Place of Presentation
  Paris, France
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 神経変性疾患における蛋白癌仮説2011
- Author(s)
  長谷川成人, 他
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 神経変性疾患における細胞内異常タンパク質の伝播2011
- Author(s)
  長谷川成人
- Organizer
  第20回パーキンソン病治療研究会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 神経変性疾患における蛋白癌仮説2011
- Author(s)
  長谷川成人, 野中隆，辻浩史，山下万貴子，増田雅美，玉岡晃，村山繁雄，新井哲明, 秋山治彦
- Organizer
  第52回日本神経学会総会(招待講演)
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Quantitative determination of TDP-43 in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and other neurodegenerative disorders.2011
- Author(s)
  Hosokawa M, Arai T, Nonaka T, Yamashita M, Tsuji H, Hasegawa M, Akiyama H
- Organizer
  Alzheimer’s Association International Conference 2011
- Place of Presentation
  パリ（フランス）
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] TARDBP/PGRN/VCPとTDP-43:TDP-43発見から5年を経て(蛋白化学の立場から)2011
- Author(s)
  長谷川成人
- Organizer
  神経変性疾患に関する調査研究班平成23年度ワークショップ
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] Histopathological analysis of progranulin knockout mice.2011
- Author(s)
  Arai T, Matsuwaki T, Hasegawa M, Akiyama H, Nonaka T, Hosokawa M, Takahashi S, Mizukami K, Asada T, Nishihara M
- Organizer
  Alzheimer’s Association International Conference 2011
- Place of Presentation
  パリ（フランス）
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] ALS/前頭側頭葉変性症の分子病態機序2011
- Author(s)
  長谷川成人, 新井哲明, 野中隆, 亀谷富由樹, 秋山治彦
- Organizer
  第28回日本医学会総会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 細胞内異常蛋白質の伝播の可能性2011
- Author(s)
  長谷川成人, 他
- Organizer
  第30回日本訴知症学会学術集会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] TDP-43による運動ニューロン変性の分子病態2011
- Author(s)
  野中隆, 長谷川成人
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] メチレンブルーによるリン酸化タウ蓄積抑制効果の検討2011
- Author(s)
  細川雅人, 新井哲明, 野中隆, 山下万貴子, 鈴掛雅美, 辻浩史, 長谷川成人, 秋山治彦
- Organizer
  第30回日本認知症学会
- Place of Presentation
  名古屋
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice.2011
- Author(s)
  Hosokawa H, Arai T, Nonaka T, Yamashita M, Suzukake M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Organizer
  Neuroscience 2011
- Place of Presentation
  ワシントン（アメリカ）
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Molecular pathology of TDP-43 proteinopathies2011
- Author(s)
  Hasegawa M
- Organizer
  3rd World Congress of Asian Psychiatry 2011
- Place of Presentation
  Melbourne(招待講演)
- Year and Date
  2011-08-02
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] TDP-43 in Motor Neuron Disease and Perry Syndrome2011
- Author(s)
  Hasegawa M, et al
- Organizer
  International Symposium on Motor Neuron Disease and Perry Syndrome
- Place of Presentation
  Tokyo(招待講演)
- Year and Date
  2011-02-22
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] TARDBP/PGRN/VCPとTDP-43:TDP-43発見から5年を経て(蛋白化学の立場から)2011
- Author(s)
  長谷川成人
- Organizer
  神経変性疾患に関する調査研究班平成23年度ワークショップ
- Place of Presentation
  東京
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 13.長谷川成人神経変性疾患における異常蛋白蓄積の分子基盤2011
- Author(s)
  長谷川成人
- Organizer
  第2回神経科学と構造生物学の融合
- Place of Presentation
  岡崎(招待講演)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] 高齢者ブレインバンクを用いたSeed, aggregation, propagation仮説の検証2011
- Author(s)
  長谷川成人, 他
- Organizer
  包括脳ネットワーク支援による融合的脳研究の展開
- Place of Presentation
  神戸(招待講演)
- Year and Date
  2011-08-23
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] FTLD-TDPおよびALSに蓄積するTDP-43蛋白の凝集体構造に関する解析2011
- Author(s)
  辻浩史, 野中隆, 新井哲明,山下万貴子, 亀谷富由樹, 細川雅人, 初田裕幸, 高尾昌樹, 村山繁雄, 齊藤祐子, 長谷川成人, 秋山治彦, Mann DMA, 詫間浩, 玉岡晃
- Organizer
  第30回日本認知症学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 13.長谷川成人神経変性疾患における異常蛋白蓄積の分子基盤2011
- Author(s)
  長谷川成人
- Organizer
  第2回神経科学と構造生物学の融合
- Place of Presentation
  岡崎(招待講演)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 細胞内異常蛋白質の伝播の可能性2011
- Author(s)
  長谷川成人, 他
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] Molecular pathology of TDP-43 proteinopathies2011
- Author(s)
  Hasegawa M
- Organizer
  3rd World Congress of Asian Psychiatry 2011
- Place of Presentation
  Melbourne(招待講演)
- Year and Date
  2011-08-02
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] TDP-43蓄積症の概念と病態解明への展望2009
- Author(s)
  長谷川成人
- Organizer
  第50回日本神経学会総会,教育講演
- Place of Presentation
  仙台
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20023038
[Presentation] プロテオミクス解析からALS/FTLDの病態解明、治療へ2009
- Author(s)
  長谷川成人
- Organizer
  第5回プロテオミクス・構造生物学講演会
- Place of Presentation
  東京
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-20023038
[Presentation] 筋萎縮性側索硬化症に蓄積するリン酸化TDP-43に関する検討2009
- Author(s)
  辻浩史, 長谷川成人, 新井哲明, (他11名)
- Organizer
  第28回日本認知症学会
- Place of Presentation
  仙台
- Year and Date
  2009-11-21
- Data Source
  KAKENHI-PROJECT-19591024
[Presentation] 変性疾患に蓄積する異常タンパク質の生化学解析とモデルの構築2009
- Author(s)
  長谷川成人
- Organizer
  神経変性疾患コンソーシアム2009
- Place of Presentation
  東京
- Year and Date
  2009-09-20
- Data Source
  KAKENHI-PROJECT-20023038
[Presentation] Phosphorylated TDP-43 in neurodegenerative disorders.2009
- Author(s)
  Arai T, Mackenzie IRA, Hasegawa M, 他8名
- Organizer
  International Conference on Alzheimer's disease 2009
- Place of Presentation
  Vienna, Austria
- Year and Date
  2009-07-15
- Data Source
  KAKENHI-PROJECT-19591024
[Presentation] リン酸化TDP-43と神経原線維変化からみるグアム島の筋萎縮性側索硬化症(ALS)の本体について2009
- Author(s)
  橋本智代, 長谷川成人, (他10名, 3番目)
- Organizer
  第50回日本神経病理学会総会学術研究会
- Place of Presentation
  高松
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-19591024
[Presentation] 筋萎縮性側索硬化症(ALS)におけるTDP-43遺伝子とタンパク質に関する検討2009
- Author(s)
  辻浩史, 長谷川成人, 亀谷富由樹, 野中隆, 新井哲明, (他8名)
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-19591024
[Presentation] TDP-43におけるSer409/410の異常リン酸化2008
- Author(s)
  犬飼有紀, 野中隆, 新井哲明, 吉田眞理,橋詰良夫, 秋山治彦, 久永眞市, 長谷川成人
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] FTDにおけるTDP-43蓄積の意義.2008
- Author(s)
  長谷川成人、他
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-20023038
[Presentation] Accumulation of phosphorylated TDP-43 in neurodegenerative disorders.2008
- Author(s)
  Arai T, Hasegawa M, Nonaka T, Kametani F, Ikeda K, Yoshida M, Hashizume Y, Beach TG, Buratti E, Baralle F, Morita M, Nakano I, Oda T, Tsuchiya K, Akiyama H
- Organizer
  International Conference on Alzheimer's Disease 2008
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-28
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] 顆粒空胞変性はリン酸化TDP-43免疫染色陽性である2008
- Author(s)
  橋本智代, 山崎峰雄, 長谷川成人, 新井哲明, 他2名
- Organizer
  第49回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19591024
[Presentation] TDP-43オーバービュー2008
- Author(s)
  長谷川成人
- Organizer
  厚生労働省「筋萎縮性側索硬化症の病態に基づく画期的治療法の開発」平成20年度ワークショップ
- Place of Presentation
  東京
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] TDP-43の細胞内封入体モデルの作製2008
- Author(s)
  野中隆, 新井哲明, 秋山治彦, 長谷川成人
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] ALS、FTLDにおけるリン酸化TDP-43の蓄積.2008
- Author(s)
  長谷川成人、他
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20023038
[Presentation] ALS、FTLDにおけるリン酸化TDP-43の蓄積2008
- Author(s)
  長谷川成人, 野中隆, 新井哲明, 犬飼有紀, 亀谷富由樹, 久永眞市, 秋山治彦
- Organizer
  第81回日本生化学会大会, シンポジウム「神経変性疾患関連遺伝子探索と機能解析」
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] FTLD、ALSに蓄積する異常TDP-43の解析2008
- Author(s)
  長谷川成人, 他
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] TDP-43凝集物に特異的に結合する抗体.2008
- Author(s)
  長谷川成人、新井哲明、野中隆、亀谷富由樹、秋山治彦
- Organizer
  第7回研究交流フォーラム
- Place of Presentation
  東京
- Year and Date
  2008-02-27
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] αシヌクレインの線維形成におけるA30P凝集核の効果2008
- Author(s)
  米谷元邦, 犬飼有紀, 野中隆, 久永眞市, 長谷川成人
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] ALS、FTLDにおけるリン酸化TDP-43の蓄積2008
- Author(s)
  長谷川成人, 他
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] TDP-43オーバービュー.2008
- Author(s)
  長谷川成人
- Organizer
  厚生労働省「筋委縮性側索硬化症の病態に基づく画期的治療法の開発」平成20年度ワークショップ
- Place of Presentation
  東京
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-20023038
[Presentation] Immunohistochemical study on phosphorylated TDP-43 protein in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula of Japan.2008
- Author(s)
  Kokubo Y, Endo M, ArainT, Akiyama H, Hasegawa M, Kuzuhara S
- Organizer
  6th International Conference on Frontotemporal Dementias Rotterdam
- Place of Presentation
  The Netherlands
- Year and Date
  2008-09-05
- Data Source
  KAKENHI-PROJECT-19390239
[Presentation] FTLD、ALSに蓄積する異常TDP-43の解析.2008
- Author(s)
  長谷川成人、他
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20023038
[Presentation] 筋萎縮性側索硬化症(ALS)、前頭側頭葉変性症(FTLD)に蓄積するTDP-43の解析.2008
- Author(s)
  野中隆、長谷川成人
- Organizer
  第3回プロテオミクス・構造生物学講演会,
- Place of Presentation
  岡崎
- Year and Date
  2008-01-13
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] TDP-43凝集物に特異的に結合する抗体.2008
- Author(s)
  長谷川成人、新井哲明、野中隆、亀谷富由樹、秋山治彦
- Organizer
  第7回研究交流フォーラム
- Place of Presentation
  東京
- Year and Date
  2008-02-27
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] FTLD、ALSに蓄積する異常TDP-43 の解析2008
- Author(s)
  長谷川成人, 新井哲明, 野中隆, 亀谷富由樹, 吉田眞理, 橋詰良夫, Beach T, 森田光哉, 中野今治, 織田辰郎, 土谷邦秋, 秋山治彦
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] Accumulation of phosphorylated TDP-43 in neurodegenerative disorders.2008
- Author(s)
  Arai T, Hasegawa M, 他13名
- Organizer
  International Conference on Alzheimer's disease 2008
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-28
- Data Source
  KAKENHI-PROJECT-19591024
[Presentation] FTDにおけるTDP-43蓄積の意義2008
- Author(s)
  長谷川成人, 新井哲明, 野中隆, 亀谷富由樹, 吉田眞理, 橋詰良夫, Thomas Beach, 森田光哉, 中野今治, 織田辰郎, 土谷邦秋, 秋山治彦
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] 筋萎縮性側索硬化症(ALS)、前頭側頭葉変性症(FTLD)に蓄積するTDP-43の解析.2008
- Author(s)
  野中隆、長谷川成人
- Organizer
  第3回プロテオミクス・構造生物学講演会,
- Place of Presentation
  岡崎
- Year and Date
  2008-01-13
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] Immunohistochemical study on phosphorylated TDP-43 protein in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula of Japan2008
- Author(s)
  Kokubo Y, Endo M, Arai T, Akiyama H, Hasegawa M, Kuzuhara S
- Organizer
  6th International Conference on Frontotemporal Dementias
- Place of Presentation
  Rotterdam, The Netherlands
- Year and Date
  2008-09-05
- Data Source
  KAKENHI-PROJECT-19390239
[Presentation] FTDにおけるTDP-43蓄積の意義2008
- Author(s)
  長谷川成人, 新井哲明, 他10名
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19591024
[Presentation] Intracellular aggregation of phosphorylated and ubiquitinated TDP-43 in SH-SY5Y cells.2008
- Author(s)
  Nonaka T, Arai T, Akiyama H, Buratti E, Baralle F E, and Hasegawa M
- Organizer
  International Conference on Alzheimer's Disease 2008
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-27
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.2008
- Author(s)
  Arai T, Hasegawa M, 他12名
- Organizer
  Society for Neuroscience 2008
- Place of Presentation
  Washington DC, USA
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-19591024
[Presentation] タウ陰性ユビキチン陽性封入体を伴う前頭側頭葉変性症におけるプログラニュリンおよびTDP-43の免疫組織化学的検討.2007
- Author(s)
  新井哲明, 長谷川成人, 他
- Organizer
  第48回目本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-19591024
[Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に出現するユビキチン陽性封入体のプロテオミクス解析とTDP-43の同定2007
- Author(s)
  長谷川成人, 新井哲明
- Organizer
  日本ヒトプロテオーム機構第5回大会
- Place of Presentation
  東京
- Year and Date
  2007-07-31
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] FTLD-UにおけるUBQ陽性封入体のプロテオミクス解析とTDP-43の同定.2007
- Author(s)
  長谷川成人
- Organizer
  第48回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Year and Date
  2007-06-01
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] ALSにおけるTDP-43の蓄積の意義.2007
- Author(s)
  長谷川成人
- Organizer
  ALSの画期的診断,治療法に関する研究班,平成19年度ワークショップ
- Place of Presentation
  東京
- Year and Date
  2007-09-07
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に出現するユビキチン陽性封入体のプロテオミクス解析とTDP-43の同定2007
- Author(s)
  長谷川成人, 新井哲明
- Organizer
  日本ヒトプロテオーム機構第5回大会,
- Place of Presentation
  東京
- Year and Date
  2007-07-31
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に蓄積するユビキチン陽性封入体の構成タンパク質の同定.2007
- Author(s)
  長谷川成人
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に蓄積するユビキチン陽性封入体の構成タンパク質の同定.2007
- Author(s)
  長谷川成人
- Organizer
  第30回目本分子生物学会年会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] TDP-43の基礎と病態。2007
- Author(s)
  長谷川成人
- Organizer
  厚生労働科学研究費補助金難治性疾患克服研究事業, 神経変性疾患に関する調査研究班ワークショップ
- Place of Presentation
  東京
- Year and Date
  2007-08-24
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] FTLD-UにおけるUBQ陽性封入体のプロテオミクス解析とTDP-43の同定2007
- Author(s)
  長谷川成人
- Organizer
  第48回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Year and Date
  2007-06-01
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] ALSにおけるTDP-43の蓄積の意義.2007
- Author(s)
  長谷川成人
- Organizer
  ALSの画期的診断, 治療法に関する研究班, 平成19年度ワークショップ
- Place of Presentation
  東京
- Year and Date
  2007-09-07
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] Phosphorylated and ubiquitinated alpha-synucleinformsfibrillar inclusions in SH-SY5Y cells2007
- Author(s)
  Nonaka, T., Watanabe, S., Iwatsubo, T., Hasegawa, M.
- Organizer
  The Society for Neuroscience 37th AnnualMeeting
- Place of Presentation
  SanDiego,USA
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] タウ陰性ユビキチン陽性封入体を伴う前頭側頭葉変性症におけるプログラニュリンおよびTDP-43の免疫組織化学的検討.2007
- Author(s)
  新井哲明, 長谷川成人, 他
- Organizer
  第48回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] Phosphorylated and ubiquitinated alpha-synuclein forms fibrillar inclusions in SH-SY5Y cells.2007
- Author(s)
  Nonaka, T., Watanabe, S., Iwatsubo, T., Hasegawa, M.
- Organizer
  The Society for Neuroscience 37th Annual Meeting
- Place of Presentation
  San Diego,USA
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] グアムPDC患者脳におけるTDP-43の蓄積2007
- Author(s)
  長谷川成人, 新井哲明, 秋山治彦, 橋本智代, 山崎峰雄, 小柳清光
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-17
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] タウ陰性ユビキチン陽性封入体を伴う前頭側頭葉変性症におけるプログラニュリンおよびTDP-43の免疫組織化学的検討2007
- Author(s)
  新井哲明, 長谷川成人, 他
- Organizer
  第48回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に出現するユビキチン陽性封入体構成蛋白の同定.2007
- Author(s)
  長谷川成人
- Organizer
  首都大バイオカンファレンス2007
- Place of Presentation
  東京
- Year and Date
  2007-10-25
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] FTLD,ALSにおけるTDP-43の蓄積.2007
- Author(s)
  長谷川成人, 新井哲明, 野中隆, 他
- Organizer
  平成19年度文科省科学研究費補助金「特定領域研究」第5領域r病態脳」夏のワークショップ(斑会議)
- Place of Presentation
  札幌
- Year and Date
  2007-08-21
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] FTLD,ALSにおけるTDP-43の蓄積.2007
- Author(s)
  長谷川成人, 新井哲明, 野中隆, 他
- Organizer
  平成19年度文科省科学研究費補助金「特定領域研究」第5領域「病態脳」夏のワークショップ(班会議)
- Place of Presentation
  札幌
- Year and Date
  2007-08-21
- Data Source
  KAKENHI-PROJECT-19591024
[Presentation] FTLD,ALSにおけるTDP-43の蓄積.2007
- Author(s)
  長谷川成人, 新井哲明, 野中隆, 他
- Organizer
  平成19年度文科省科学研究費補助金「特定領域研究」第5領域「病態脳」夏のワークショップ(班会議)
- Place of Presentation
  札幌.
- Year and Date
  2007-08-21
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に出現するユビキチン陽性封入体のプロテオミクス解析とTDP-43の同定.2007
- Author(s)
  長谷川成人, 新井哲明
- Organizer
  日本ヒトプロテオーム機構第5回大会,
- Place of Presentation
  東京
- Year and Date
  2007-07-31
- Data Source
  KAKENHI-PROJECT-19591024
[Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に出現するユビキチン陽性封入体のプロテオミクス解析とTDP-43の同定.2007
- Author(s)
  長谷川成人, 新井哲明
- Organizer
  日本ヒトプロテオーム機構第5回大会,
- Place of Presentation
  東京
- Year and Date
  2007-07-31
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] TDP-43の基礎と病態.2007
- Author(s)
  長谷川成人
- Organizer
  厚生労働科学研究費補助金難治性疾患克服研究事業, 神経変性疾患に関する調査研究班ワークショップ
- Place of Presentation
  東京
- Year and Date
  2007-08-24
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に出現するユビキチン陽性封入体構成蛋白の同定.2007
- Author(s)
  長谷川成人
- Organizer
  首都大バイオカンファレンス2007
- Place of Presentation
  東京
- Year and Date
  2007-10-25
- Data Source
  KAKENHI-PROJECT-18023042
[Presentation] Proteasome inhibition by alpha-synuclein in living cells.2006
- Author(s)
  Nonaka T, Hasegawa M
- Organizer
  The 10th International Conference on Alzheimer's Disease and Related Disorders
- Place of Presentation
  Madrid, Spain
- Year and Date
  2006-07-19
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] CK2 is the major enxyme in brain that generates PSer129 epitope of alpha-synuclein.2006
- Author(s)
  Hasegawa M, Ishii A, Nonaka T, Saito T, Arai T, Hisanaga S, Iwatsubo T
- Organizer
  The 6th Annual Meeting of International College of Geriatric Psychoneuropharmacology (ICGP)
- Place of Presentation
  Hiroshima, Japan
- Year and Date
  2006-10-05
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] シヌクレイノパチーの基礎研究2006
- Author(s)
  長谷川成人
- Organizer
  第25 回日本認知症学会, シンポジウム3 「シヌクレイノパチーの臨床と基礎研究」
- Place of Presentation
  広島
- Year and Date
  2006-10-07
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] Small molecule inhibitors of alpha-synuclein filament assembly.2006
- Author(s)
  Masuda M, Suzuki N, Taniguchi S, Oikawa T, Nonaka T, Iwatsubo T, Hisanaga S, Goedert M, Hasegawa M
- Organizer
  The 10th International Conference on Alzheimer's Disease and Related Disorders
- Place of Presentation
  Madrid, Spain
- Year and Date
  2006-07-19
- Data Source
  KAKENHI-PROJECT-18300117
[Presentation] αシヌクレイン
- Author(s)
  長谷川成人
- Organizer
  第8回　パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  京都ホテルオークラ
- Year and Date
  2014-10-02 – 2014-10-04
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110738
[Presentation] 神経変性疾患の原因となるタンパク質の構造異常とその伝播
- Author(s)
  長谷川成人
- Organizer
  第４回神経科学と構造生物学の融合研究会,
- Place of Presentation
  岡崎
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110738
[Presentation] Three autopsy cases of FTD-MND with progressive aphasia.
- Author(s)
  Kawakami I, Higashi S, Aoki N, Niizto K, Ohshima K, Katsuse O, Togo T, Kobayashi Z, Hosokawa M, Tsuji H, Tamaoka A, Hasegawa M, Arai T, Tsuchiya K, Hirayasu Y, Akiyama H
- Organizer
  The 8th International Conference on Frontotemporal Dementias
- Place of Presentation
  Manchester, UK
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 進行性失語が前景に立った運動ニューロン疾患を伴う前頭側頭型認知症の二剖検例
- Author(s)
  河上緖，東晋二，青木直哉，新里和弘，大島健一，安野みどり，羽賀千恵，下村洋子，鈴木京子，勝瀬大海，都甲崇，小林禅，辻浩史，玉岡晃，長谷川成人，新井哲明，土谷邦秋，平安良雄，秋山治彦
- Organizer
  第53回日本神経病理学会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] 3R and 4R tau isoforms in paired helical filaments in Alzheimer’s disease.
- Author(s)
  Hasegawa M, Dan A, Watanabe S, Kondo H, Akiyama H, Mann DM, Saito Y, Murayama S
- Organizer
  International symposium "New Frontier of Molecular Neuropathology 2014";
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PUBLICLY-25110738
[Presentation] Insoluble TDP-43 prepared from diseased brains has prion-like properties.
- Author(s)
  Nonaka T, Masuda-Suzukake M, Tetsuaki Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DMA, Akiyama H and Hasegawa M;
- Organizer
  Alzheimer's Association International Conference (AAIC2013); Boston, USA,
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PUBLICLY-25110738
[Presentation] ALSとTDP-43の生化学.
- Author(s)
  長谷川成人, 野中隆, 辻浩史, 玉岡晃, 吉田眞理, 村山繁雄, Mann David, 新井哲明, 秋山治彦
- Organizer
  第53回日本神経病理学会総会学術集会
- Place of Presentation
  新潟
- Invited
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 神経変性疾患の原因となるタンパク質の構造異常とその伝播
- Author(s)
  長谷川成人
- Organizer
  第４回神経科学と構造生物学の融合研究会
- Place of Presentation
  岡崎
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 活性型カゼインキナーゼ１デルタの共発現によるTDP-43の局在変化および細胞内蓄積
- Author(s)
  長谷川成人、野中隆
- Organizer
  第87回　日本生化学会大会
- Place of Presentation
  国立京都国際会館・グランドプリンスホテル京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PUBLICLY-25110738
[Presentation] Insoluble TDP-43 prepared from diseased brains has prion-like properties.
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann D, Akiyama H and Hasegawa M
- Organizer
  Alzheimer's Association International Conference (AAIC2013)
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] Screening of the SOD1, TARDBP and FUS mutations and the pathological studies in Japanese cases with familial and sporadic amyotrophic lateral sclerosis.
- Author(s)
  Arai T, Arai M, Itokawa M, Yoshida M, Tamaoka A, Kobayashi Z, Hosokawa M, Hasegawa M, Nonaka T, Tsuji H, Yamada M, Matsui M, Kaji R, Nakashima K, Kuwano R, Takahashi S, Asada T, Akiyama H
- Organizer
  Alzheimer’s Association International Conference 2012
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Intracellular seeding model reproduces characteristic features of affected neurons in TDP-43 proteinopathy.
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Yoshida M, Murayama S, Man DMA, Akiyama H, Hasegawa M
- Organizer
  The 8th International Conference on Frontotemporal Dementias
- Place of Presentation
  Manchester, UK
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice
- Author(s)
  Hosokawa M, Arai T, Masuda-Suzukake M, Nonaka T, Yamashita M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Organizer
  The 11th International Conference on Alzheimer's and Parkinson's Diseases
- Place of Presentation
  Firenze, Italy.
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] Three Autopsy Cases of FTD-MND with Progressive Aphasia
- Author(s)
  Kawakami I, Higashi S, Aoki N, Niizato K, Oshima K, Katsuse O, Togo T, Kobayashi Z, Hosokawa M, Tsuji H, Tamaoka A, Hasegawa M, Arai T, Tsuchiya K, Hirayasu Y, Akiyama H
- Organizer
  8th International Conference on FTD
- Place of Presentation
  Manchester, UK
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] 神経変性疾患の分子基盤と進行機序 ―患者脳の解析から導かれた新しい考え方とその検証―
- Author(s)
  長谷川成人
- Organizer
  平成２５年度文部科学省新学術領域研究生命科学系３分野がん・ゲノム・脳支援活動合同シンポジウム,
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] ALS/前頭側頭葉変性症の分子病態機序
- Author(s)
  長谷川成人, 他
- Organizer
  第28回日本医学会総会2011
- Place of Presentation
  東京(招待講演)(中止の為オンラインで公開)
- Data Source
  KAKENHI-PUBLICLY-23110526
[Presentation] Methylene blue reduced tau phosphorylation and aggregation in P301L transgenic mice.
- Author(s)
  Hosokawa M, Arai T, Suzukake M, Yamashita M, Nonaka T, Hasegawa M, Akiyama H
- Organizer
  Alzheimer’s Association International Conference 2012
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 神経変性疾患の分子基盤と進行機序 ―患者脳の解析から導かれた新しい考え方とその検証―
- Author(s)
  長谷川成人
- Organizer
  平成２５年度　文部科学省新学術領域研究生命科学系３分野がん・ゲノム・脳支援活動合同シンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110738
[Presentation] Prion-like properties of pathological TDP-43 in diseased brains.
- Author(s)
  野中隆, 鈴掛雅美, 新井哲明, 赤津裕泰, 小尾智一, 吉田眞理, 村山繁雄, Mann D, 秋山治彦, 長谷川成人
- Organizer
  第54回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 進行性失語が前景に立った運動ニューロン疾患を伴う前頭側頭型認知症の二剖検例.
- Author(s)
  河上緒, 東晋二, 青木直哉, 新里和弘, 大島健一, 安野みどり, 羽賀千恵, 下村洋子, 鈴木京子, 勝瀬大海, 都甲崇, 小林禅, 辻浩史, 玉岡晃, 長谷川成人, 新井哲明, 土谷邦秋, 平安良雄, 秋山治彦
- Organizer
  第53回日本神経病理学会総会学術集会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] シード依存的な細胞内TDP-43蓄積による細胞死の誘導.
- Author(s)
  野中隆, 鈴掛(増田)雅美, 新井哲明, 吉田眞理, 村山繁雄, Mann David, 秋山治彦, 長谷川成人
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば市
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] Exome sequencing of Parkinson’s disease in order to identify genetic variants with high disease-risk.
- Author(s)
  Satake, W., Ando, Y., Tomiyama, H., Kashihara, K., Mochizuki, H., Murayama, S., Takeda, A., Hasegawa, K., Tsuji, S., Yamamoto, M., Murata, M., Hattori, N., Toda, T.
- Organizer
  18th International Congress of Parkinson’s Disease and Movement Disprders.
- Place of Presentation
  Stockholm（Sweden）
- Year and Date
  2014-06-08 – 2014-06-12
- Data Source
  KAKENHI-PROJECT-221S0003
[Presentation] tangle-predominant dementiaの側座核におけ病理学的検討.
- Author(s)
  河上緒, 長谷川成人, 新井哲明, 青木直哉, 勝瀬大海, 東晋二, 大島健一, 新里和弘, 近藤ひろみ, 羽賀千恵, 下村洋子, 山下万貴子, 鈴木京子, 平安良雄, 秋山治彦
- Organizer
  第54回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591694
[Presentation] 神経変性疾患の細胞病理を形成する蛋白質のプリオン様特性
- Author(s)
  長谷川成人
- Organizer
  第８回臨床ストレス応答学会
- Place of Presentation
  松本
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110738
[Presentation] ALS/前頭側頭葉変性症の分子病態機序
- Author(s)
  長谷川成人, 他
- Organizer
  第28回日本医学会総会2011
- Place of Presentation
  東京(招待講演)(中止の為オンラインで公開)
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 神経変性疾患の細胞病理を形成する蛋白質のプリオン様特性
- Author(s)
  長谷川成人
- Organizer
  第８回臨床ストレス応答学会
- Place of Presentation
  松本
- Invited
- Data Source
  KAKENHI-PROJECT-23240050
[Presentation] 3R and 4R tau isoforms in paired helical filaments in Alzheimer’s disease
- Author(s)
  Hasegawa M, Dan A, Watanabe S, Kondo H, Akiyama H, Mann DM, Saito Y, Murayama S
- Organizer
  International symposium "New Frontier of Molecular Neuropathology 2014"
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-23240050

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# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
175. 坂下直実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
176. 竹屋元裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
177. 漆谷真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
178. 久永眞市

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
179. 樋口真人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
180. 津田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
181. 桝和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
182. 木村実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
183. 崎村建司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
184. 玉岡晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
185. 矢部一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

hasegawa masato 長谷川 成人

HASEGAWA Masato 長谷川 成人

長谷川 成人 ハセガワ マサト

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疾患特徴的タウ病理の形成と伝達機構Principal Investigator

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Propagation of prion-like proteins and cellular responsesPrincipal Investigator

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Molecular bases of pathogenic proteins and mechanisms of the propagationPrincipal Investigator

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細胞内異常タンパク質の蓄積機構Principal Investigator

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細胞内異常タンパク質と回路選択的神経変性Principal Investigator

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Molecular mechanisms of pathological protein propagation and its regulationPrincipal Investigator

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hasegawa masato 長谷川成人

HASEGAWA Masato 長谷川成人

長谷川成人ハセガワマサト