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KATO Ryuichi  加藤 隆一

ORCIDConnect your ORCID iD *help
Researcher Number 40112685
External Links
Affiliation (based on the past Project Information) *help 1990 – 1994: Keio University School of Medicine Professor, 医学部, 教授
1986 – 1994: Keio University School of Medicine Professor, 医学部, 教授
1993: 慶応大学, 医学部, 教授
1991: Keio Univ. School of Med., Dept. of Pharmacol. Prof., 医学部, 教授
1987 – 1988: 慶應義塾大学, 医学部, 教授
1986: Professor, School of Medicine, Keio University, 医学部, 教授
1985: 慶応義塾大学, 医, 教授
Review Section/Research Field
Principal Investigator
General pharmacology / 応用薬理学・医療系薬学
Except Principal Investigator
General pharmacology / 応用薬理学・医療系薬学 / 代謝生物化学
Keywords
Principal Investigator
代謝的活性化 / 薬物代謝酵素 / チトクロムP-450 / チトクロームP-450 / DNA傷害 / 脱感作 / 薬物代謝 / 化学発癌 / 細菌内毒素 / 性差 … More / 種差 / カテコラミン分泌 / Gene expression / ヒト肝 / Cytochrome P-450 / チトクロームP450 / 成長ホルモン / ニトロピレン / ヘテロサイクリックアミン / アセチル化酵素 / DNA付加体 / DNA修復 / 活性中間体 / PC12 / 副腎髄質クロマフィン細胞 / 細胞内Ca^<2+>濃度 / 癌原物質 / チトクロムPー450 / 細胞内カルシウム濃度 / nicotinic receptor / inositol phosphate / Ca^<++> mobilization / chromaffin cells / 培養日数 / サイクリックGMP / 細胞内遊離Ca^<2+> / イノシトール三リン酸 / 牛副腎髄質培養クロマフィン細胞 / イノシトール三隣酸 / 細胞内Ca^<++>動員 / ニコチン受容体 / ムスカリン受容体 / drug metabolism / cloning / cytochrome P-450 / 遺伝子クローニング / クローニング / testosterone hydroxylation / growth hormone / estrogen / androgen / sex-specific cytochrome P-450 / アミノ酸セクエンス / 脳下垂体 / 雌雄固有 / テストステロン水酸化 / アンドロジェン / エストロジェン / P-450-female / P-450-male / 性特異性チトクロムP-450 / Sulfotransferase / Acetyltransferase / Metabolic activation / Drug metabolizing enzymes / Carcinogenicity / Mutagenicity / Ames test / ベンチジン / サルモネラ菌 / N,O‐アセチル転移反応 / アリルアミン / 異所遺伝子発現 / アセチル化酵素遺伝子 / Anes試験 / 異種細胞内発現 / 硫酸転移酵素 / アセチル転移酵素 / 代謝活性化 / 発癌性 / 変異原性 / Ames試験 / Diagnosis by gene analysis / Mephenytoin, / Cytochrome P450, / Pharmacogenetics, / Racial difference, / Interindividual differnce, / Drug metabolism, / Drug response, / チトクロムP450 / 遺伝子診断 / メフェニトイン / テトクロームP450 / 薬理遺伝学 / 人種差 / 個人差 / 薬物反応性 / P-450 mixture / Human drug metabolism / ヒト薬物代謝能 / 異所的発現 / チトクロームb_5 / 酵母内遺伝子発現 / Dexamethasone / HNF-4 / GRE / Growth hormone / Thyroid hormone / Hepatocyte / Phenobarbital / 初代培養肝細胞 / 酵素誘導 / 単離肝細胞 / チトクロ-ムPー450 / トリヨードチロニン / フェノバルビタール誘導 / 肝核因子-4 / 遺伝子発現 / グルココルチコイド反応性エレメント / 甲状腺ホルモン / フェノバルビタール / Microcarrier beads / Perfusion / Desensitization / PC 12 cells / Adrenal chromaffin cells / Catecholamine release / Intracellular Ca^<2+> concentration / 副腎髄質細胞 / 分泌 / マイクロキャリア-ビ-ズ / 潅流 / PC 12 / N-水酸化体 / ヒトへの外挿 / Oーアセチラーゼ / サルフォトランスフェラーゼ / 細胞内遊離【Ca^(2+)】濃度,【Ca^(2+)】取り込み,脱感作,C-キナーゼ,副腎髄質クロマフィン細胞. / O-アセチラ-ゼ / サルフォトランスフェラ-ゼ / mRNA / インターフェロン / インターロイキン / 腫瘍壊死因子 / 一酸化窒素 / 血管内皮細胞 / 血管平滑筋細胞 / P450 / 内皮 / デキサメサゾン / N-メチルアルギニン / 平滑筋細胞 / NO生成酵素 / IL-1β / TNF-α / 細胞増殖 / ピュ-ロマイシン / アクチノマイシンD / メチルアルギニン / NC合成酵素 / ラット大動脈 / ノルエピネフリン / ヒドロキシアリ-ルアミン / 臓器特異性 / 潅流系 / ベンズピレン水酸化 / メフェニトイン水酸化 / 遺伝薬理学 / 副腎髄質 … More
Except Principal Investigator
Pー450 / チトクロ-ムPー450 / 総括班 / 薬物受容体 / 創薬基礎科学 / 筋小胞体 / チトクロームPー450 / Lymphokine / Immune Desponse / T Cell Growth / Tumor Antigen / Tumor Supressor Gene / Tumor Promoter / Viral Oncogene / Oncogene / リンフォカイン / 免疫応答 / T細胞の増殖 / 腫瘍抗原 / がん抑制遺伝子 / 発がんプロモ-タ- / ウイルス発がん / がん遺伝子 / steroid hormone hydroxylases / growth hormone / estrogen / androgen / sex-specific cytochrome P-450 / 薬物代謝酵素 / ステロイド水酸化酵素 / 成長ホルモン / エストロジェン / アンドロジェン / 性特異性チトクロムP-450 / GTP binding regulatory protein / Catecholamine / Acetylcholine / Histamine / Signalling / Receptor / Neurotransmitter / アラキドン酸 / GTP結合蛋白 / カテコールアミン / アセチルコリン / ヒスタミン / 情報伝達 / 受容体 / 神経伝達物質 / Dopamine / Nicotine / Serotonin / Ethanol / Tachykinin / Endothelin / Nitric Oxide / GABA receptor / Drug Receptor / ドパミン / ニコチン / セロトニン / エタノール / タキキニン受容体 / エンドセリン / 一酸化窒素(NO) / GABA受容体 / molecular probe / intracellular message system / signal transduction / 創薬 / 細胞内情報伝達系 / 機能探索子 / 機能性蛋白質 / 細胞内情報伝達 / Blood vessel / Aging / Dopamine receptor / Potassium channel / Opioid receptor / Primary cultured cells / Cardiac receptor / Desensitization / 細胞内情報媒介系 / シナプスの可塑性 / イオンチャンネル / 加齢に伴う変化 / 薬物依存 / 感作及び脱感作現象 / 生理と病態 / モルヒネ耐性 / 脂肪酸 / 加齢 / 過感作状態 / カリウム チャンネル / 受容体の脱感作と過感作 / 血管の薬物受容体 / 受容体機能と加齢 / ド-パミン受容体 / カリウムチャンネル / オピオイド受容体 / 培養細胞と薬物受容体 / 心筋の薬物受容体 / 受容体の脱感作の過感作 / 研究の総括 / チトクロームPー450の分子生物学 / 遺伝子発現 / ミクロソーム / ミトコンドリア / 細胞胞内局在性 / 分子多様性 / 薬物の酸化的代謝 / 脂溶性生理活性物質 / ヘム蛋白質 / チトクロ-ムP-450 / リード化合物 / 分子薬理研究用プローブ / 糖質コルチコイド / インタ-ロイキン / サイトカイン / 走化機構 / 走化因子 / メタルプロテア-ゼ / 好中球 / PAF受容体 / イノシト-ルによるCa放出機構 / CaによるCa放出機構 / 骨格筋 / 副腎髄質細胞 / 肝細胞 / 細胞内Ca量 / Ca動員機構 / 発現調節 / 発現の分子機構 / 筋形質膜 / CaによるCa放出 / ベジクル脂質平面膜 / パッチ固定法 / イノシトール,三燐酸 / リアノジン / Ca電流 Less
  • Research Projects

    (39 results)
  • Co-Researchers

    (98 People)
  •  化学発癌における活性中間体の動態と標的臓器DNA傷害-臓器および種特異性との関連Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Keio University
  •  血管における内皮依存性NO生成酵素誘導の機構Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Keio University
  •  受容体を中心とした新しい薬物開発の基礎研究

    • Principal Investigator
      鹿取 信
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kitasato University
  •  Drug receptor function and its regulation

    • Principal Investigator
      TODA Noboru
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Shiga University of Medical Science
  •  Analysis of human interindividual and racial differeness of drug response and metabolism : Approach by the method of diagnosis by gene analysisPrincipal Investigator

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Keio University
  •  Establishment of high sensitive Salmonella tester strains expressing mammalian acetvltransferase and sulfotransferasePrincipal Investigator

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Keio University
  •  化学発癌における活性中間体の動態と標的臓番DNA傷害ー臓器よおび種特異性との関連Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Keio University
  •  アゴニストおよび張力刺激による血管内皮由来弛緩因子の生成増強機構Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Keio University
  •  Establishment of the pharmacological sciences to elucidate the signal transduction system.

    • Principal Investigator
      HIDAKA Hiroyoshi
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Nagoya University
  •  化学発癌における活性中間体の動態と標的臓器DNA傷害ー臓器および種特異性との関連Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Keio University
  •  アゴニストおよび張力刺激による血管内皮由来弛緩因子の生成増強機構Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Keio University
  •  チトクロ-ムPー450の分子生物学、研究の総括

    • Principal Investigator
      大村 恒雄
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  Assessment of human drug metabolism by expression of cytochrome P-450 in yeasts.Principal Investigator

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Keio University
  •  癌原物質の活性化を行うヒト肝チトクロムPー450の薬理遺伝学差異の研究Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Keio University
  •  チトクロ-ムPー450の分子生物学、研究の総括

    • Principal Investigator
      大村 恒雄
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  チトクロ-ムPー450の分子生物学:発現の分子機構

    • Principal Investigator
      大村 恒雄
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  カルシウムイオンの動員とその調節機構

    • Principal Investigator
      栗山 煕
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  炎症反応における細胞間シグナル・ネットワ-クー分子レベルにおける解析とその制御

    • Principal Investigator
      鹿取 信
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kitasato University
  •  Regulation of expression of cytochrome P-450 by hormonal factor in primary cultured rat hepatocytes.Principal Investigator

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Keio University
  •  チトクロームPー450の分子生物学、研究の総括

    • Principal Investigator
      大村 恒雄
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  カルシウムイオンの動員とその調節機構

    • Principal Investigator
      栗山 煕
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  Ca^<++>流入とカテコラミン分泌の急速脱感作の分子機構のリアルタイム同時測定による研究Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Keio University
  •  Ca^<++>流入とカテコラミン分泌の急速脱感作の分子機構のリアルタイム同時測定による研究Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Keio University
  •  Physiology and pathophysiology of drug receptor mechanisms

    • Principal Investigator
      KURIYAMA Kinya
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Simultaneous Monitoring of Intracellular Calcium Concentration and Catecholamine Release from Superfused PC 12 Cells and Adrenal Chromaffin Cells Cultured on Microcarrier Beads.Principal Investigator

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B).
    • Research Field
      General pharmacology
    • Research Institution
      Keio University
  •  チトクロームP-450の分子生物学:発現の分子機構

    • Principal Investigator
      藤井 義明
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  チトクロームPー450の分子生物学、研究の総括

    • Principal Investigator
      大村 恒雄
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  Information Exchange on Cancer Research with North American Countries

    • Principal Investigator
      YAMAGUCHI Nobuo, 河井 貞明
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      The Institute of Medical Science, The University of Tokyo
  •  チトフロームPー450の分子生物学

    • Principal Investigator
      大村 恒雄
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Institution
      Kyushu University
  •  癌原物質の代謝的活性化機構と発癌の特異性に関する研究ーー特にヒトの外挿Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Keio University
  •  Menbrane phospholipase c activation and signal transduction in relation to change of receptor-linkage mechanismPrincipal Investigator

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Keio University
  •  副腎クロマフィン細胞における受容体刺激に伴うカルシウムイオン流入の急速脱感作機構Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Keio University
  •  チトクロームP-450の生理機能についての基礎研究

    • Principal Investigator
      大村 恒雄
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      代謝生物化学
    • Research Institution
      Kyushu University
  •  癌原物質の代謝的活性化機構と発癌の特異性に関する研究ー特にヒトへの外挿Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Keio University
  •  癌原物質の代謝的活性化機構と発癌の特異性に関する研究-特にヒトへの外挿-Principal Investigator

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Keio University
  •  Molecular mechanism of development and regulation of sex-specific cytochrome P-450 in rat liverPrincipal Investigator

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      School of Medicine, Keio University
  •  Molecular pharmacology of signalling mechanism in synapse

    • Principal Investigator
      SEGAWA Tomio
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Analysis of mechanism of neonatal imprinting of drug-metabolizing enzymes of rat liver

    • Principal Investigator
      YAMAZOE Yasushi, 鎌滝 哲也
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      School of Medicine, Keio University
  •  Production of human liver cytochrome P-450 by using a biotechnological method and development of the clinical applicationPrincipal Investigator

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      School of Medicine, Keio University
  • 1.  渡辺 民朗 (40006101)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 2.  大村 恒雄 (80029933)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 3.  奥田 九一郎 (80034156)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 4.  YAZUMORI Toshio (70182350)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 5.  NAGATA Kiyoshi (80189133)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 6.  YAMAZOE Yasushi (00112699)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 7.  NAKAKI Toshio (30164148)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 8.  藤井 義明 (00098146)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 9.  渡部 烈 (00057316)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 10.  KURIYAMA Kinya (20079734)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 11.  出川 雅邦 (50134002)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 12.  ENDO Makoto (50009990)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 13.  SASAKAWA Nobuyuki (20187107)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 14.  石村 巽 (40025599)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 15.  大西 克成 (10037400)
    # of Collaborated Projects: 4 results
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  • 20.  若林 敬二 (60158582)
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  • 30.  葛西 道生 (40022595)
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  • 33.  鹿取 信 (50050365)
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  • 34.  大垣 比呂子 (00150201)
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  • 35.  山野 俊雄 (40028270)
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  • 36.  片桐 正之 (30019442)
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  • 37.  鎌滝 哲也 (00009177)
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  • 39.  FURUKAWA Tatsuo (60078582)
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  • 40.  TAKAORI Shuji (10025538)
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  • 45.  UI Michio (50001037)
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  • 64.  YUASA Yasuhito (80111558)
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  • 70.  KUROKI Toshio (90006073)
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  • 74.  TSUKITA Shouichiro (50155347)
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  • 75.  UEDE Toshimitsu (00160185)
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  • 77.  YOSHIKE Kunito (90072925)
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  • 78.  KIKUCHI Kunimi (20006117)
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  • 79.  MARUHASHI Akira (30114135)
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  • 80.  SHIBUYA Masabumi (10107427)
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  • 81.  NOMURA Nobuo (20147862)
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  • 87.  神原 武 (60040151)
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  • 89.  江角 浩安 (70160364)
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  • 90.  今井 喜郎 (60029949)
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  • 91.  佐藤 了 (00029927)
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  • 92.  MIYADO Shinji
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    # of Collaborated Products: 0 results
  • 93.  FUJITA Masataka
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    # of Collaborated Products: 0 results
  • 94.  日比 清勝
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    # of Collaborated Products: 0 results
  • 95.  真砂 央
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    # of Collaborated Products: 0 results
  • 96.  甲斐 文夫
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    # of Collaborated Products: 0 results
  • 97.  KAMATAKI Tetsuya
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    # of Collaborated Products: 0 results
  • 98.  OKAWA Hideo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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