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TOKINO Takashi  時野 隆至

ORCIDConnect your ORCID iD *help
… Alternative Names

時野 隆志  トキノ タカシ

時野 隆臣  トキノ タカオミ

時野 隆至  トキノ タカシ

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Researcher Number 40202197
Other IDs
External Links
Affiliation (Current) 2025: 札幌保健医療大学, 保健医療学部, 教授
2025: 札幌医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2001 – 2023: Sapporo Medical University School of Medicine, Professor, 医学部, 教授
2007: 札幌医大, 医学部, 教授
2002 – 2003: 札幌医科大学, 医学部・附属がん研究所, 教授
2000: 札幌医科大学, 附属がん研究所, 教授
1999 – 2000: 札幌医科大学, 医学部・がん研究所, 教授 … More
1999: 札幌医科大学, 医学部・付属がん研究所, 教授
1998 – 1999: 札幌医科大学, がん研, 教授
1998 – 1999: 札幌医科大学, がん研究所, 教授
1998: 札幌医科大学, 医学部, 教授
1995 – 1997: 東京大学, 医科学研究所, 助教授
1996: 東京大学医科学研究所, 分子病態研究施設, 助教授
1995: 東京大学, 医科学研究所・分子病態研究施設, 助教授
1991: 癌研究会, 癌研究所・生化学部, 研究員
1990 – 1991: (財)癌研究会, 癌研究所・生化学部, 研究員
1990: 癌研究会癌研究所, 生化学部, 研究員 Less
Review Section/Research Field
Principal Investigator
Digestive surgery / Surgical dentistry / Basic Section 50010:Tumor biology-related / Tumor biology / Biological Sciences / Complex systems / Human genetics
Except Principal Investigator
Cerebral neurosurgery / Obstetrics and gynecology / Biological Sciences … More / Obstetrics and gynecology / 内分泌・代謝学 / Surgical dentistry / Experimental pathology / Human genetics Less
Keywords
Principal Investigator
p53 / 癌 / がん抑制遺伝子 / 細胞周期 / アポトーシス / トランスレーショナルリサーチ / がん / p73 / p63 / 遺伝子治療 … More / チェックポイント / ユビキチンリガーゼ / 薬剤感受性 / ゲノム / 癌抑制遺伝子 / TP53 / cell cycle / apoptosis / tumor suppressor gene / 転写活性化 / 標的遺伝子 / 遺伝子 / トランスレーションリサーチ / 微小管阻害剤 / 遺伝子欠失 / 遺伝子増幅 / ヒトゲノム / がんゲノム / 長鎖非コードRNA / translationalresearch / checkpoint / ubiquitinliease / microtubule inhibitor / drug sensitivity / トランスレーショナル リサーチ / Ubiquitin ligase / Cell Cycle Control / Chemosensitivity / Translational Research / Cancer / 感受性診断 / 口腔癌 / 微小管脱重合阻害剤 / 有糸分裂 / 細胞周期制御 / 臨床 / transcriptional regulation / Notch / 発がん / マイクロアレイ / SCN3B / 転写制御 / angiogenesis / transcriptional activation / target gene / 癌制御遺伝子 / 血管新生 / 癌仰制遺伝子 / 転移・浸潤 / FOXF1 / マイクロRNA / 非コードRNA / 転写因子 / バイオインフォマティクス / 分子標的 / MDM4 / RNA干渉 / PARP-1 / PARP-1阻害剤 / CHFR / 歯学 / 癌(がん) / がん挿制遺伝子 / がん治療 / ウイルスベクター / 大腸癌 / リンパ節転移 / 第8染色体 / MLH1 / 食道癌 / 遺伝子診断 / ポジショナル・クローニング / ヒト・ゲノム / 高多型性VNTRマ-カ- / RFLP(DNA多型性) / PCR法(DNA増幅法) / CAリピ-ト / RFLP … More
Except Principal Investigator
p53 / angiogenesis / 卵巣癌 / DNA microarray / hsp70 / bag-1 / gene therapy / Tet-On / glioblastoma / glioma / BAI1 / アポトーシス / 転写因子 / p73 / p63 / シグナル伝達 / がん遺伝子 / 癌 / ゲノムアノテーション / メタゲノム / ゲノム多型 / ゲノムアッセンブル / スーパーコンピューター / メタゲノム解析 / 1細胞解析 / RNA-Seq / エピゲノム / リシーケンシング / 新規ゲノム配列決定 / 次世代DNAシーケンサー / familial occurrence / microsatelite analysis / Moyamoya disease / サイトカイン / 遺伝子解析 / もやもや病 / Taxol-induced apoptosis / beta-catemn gene / endometrial cancer / ovarian cancer / SKT11 / ベータカテニン / DNA修復遺伝子 / Docetaxel / Tax01 / Bcl-2 / インターロイキン6 / SKT-11 / ベーターカテニン / DNA修複遺伝子 / Taxiol誘発apoptosis / taxol誘導アポトーシス / DNAmicroarray / β-catenin遺伝子 / 子宮内膜癌 / angiogenssis / astrocytoma / hyperammonemia / mitochondria / cardiomegaly / hypoglycemia / primary carnitine deficiency / fatty liver / Carnitine Transporter / Carnitine / カルニチン輸送担体 / 高アンモニア血症 / ミトコンドリア / 心肥大 / 低血糖症 / 原発性カルニチン欠乏症 / 脂肪肝 / カルニチントランスポーター / カルニチン / がん分子標的薬剤 / ATL発症リスク / ATL発がん機序 / がん化学予防 / 分子疫学コーホート研究 / ATL発症予防 / 国際交流 / 個別化がん予防 / ゲノム・エピゲノム解析支援 / アカデミア創薬 / 次世代分子解析技術 / ゲノムコーホート研究 / 病理形態学 / 遺伝子改変マウス / 国際研究者交流 / 若手支援 / 歯学 / 遺伝子 / エピジェネティクス / 臨床腫瘍学 / 細胞分化 / 発生 / 微小管阻害剤(タキサン系抗癌剤) / CyclinB / 細胞周期M期 / BRAC pathway / Fanconi-anemia / ASC / TMS1 / エピジェネティクスの異常 / TCF2 / MCA法 / メチル化 / エピジェネティックス / cDNAマイクロアレイ / 抗癌剤耐性 / プロテオミクス / 2-D電気泳動 / マイクロアレイ / 発生・分化 / 発現制御 / 遺伝要因 / 発がん / マイクロサテライトマーカー / DNA多型マーカー / 全ゲノムスキャニング / 罹患同胞対法 / 連鎖解析 / 胃がん / 2国間共同研究 / 2国間協同研究 / ヒトゲノム / がん転移 / DNA修復 / がん細胞 / がん抑制遺伝子 / 癌抑制遺伝子 / 癌遺伝子 / 遺伝子診断 / 白血病 / 神経芽腫 / 肺癌 / 消化器癌 / 癌の遺伝子診断 / RFLP / 染色体転座 / 乳癌 / 腎癌 / 染色体地図 / 遺伝子増幅 / 染色体欠失 / MCC遺伝子 / 家族性大腸腺腫症 Less
  • Research Projects

    (34 results)
  • Research Products

    (245 results)
  • Co-Researchers

    (246 People)
  •  新規がん治療法の開発をめざしたp53との合成致死に関与する遺伝子群の探索Principal Investigator

    • Principal Investigator
      時野 隆至
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Sapporo Medical University
  •  p53 pathway and its potential targeted therapeutic approachPrincipal Investigator

    • Principal Investigator
      Tokino Takashi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Sapporo Medical University
  •  A better understanding of p53 network for cancer therapyPrincipal Investigator

    • Principal Investigator
      TOKINO Takashi
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Sapporo Medical University
  •  Platform for Advanced Genome Science

    • Principal Investigator
      KOHARA Yuji
    • Project Period (FY)
      2016 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
    • Research Institution
      National Institute of Genetics
  •  バイオインフォマティクスを活用したp53ネットワーク探索と癌治療への応用Principal Investigator

    • Principal Investigator
      時野 隆至
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Sapporo Medical University
  •  New insights into p53 signaling regulation to cure cancerPrincipal Investigator

    • Principal Investigator
      TOKINO Takashi
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Sapporo Medical University
  •  High-throughput screening for peptides that inhibit the interaction or MDM4 with p53Principal Investigator

    • Principal Investigator
      TOKINO Takashi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Sapporo Medical University
  •  Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

    • Principal Investigator
      IMAI Kohzoh, 中村 祐輔
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      The University of Tokyo
  •  RNA干渉技術を駆使してアポトーシス誘導シグナルを増強した遺伝子治療法の開発Principal Investigator

    • Principal Investigator
      時野 隆至
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Sapporo Medical University
  •  Expression analysis of SFRP family genes for development of molecular targeted therapy for oral cancer

    • Principal Investigator
      SOGABE Yohei
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Sapporo Medical University
  •  Functional analysis of CHFR: Diagnostic and therapeutic application for oral squamous cell cancerPrincipal Investigator

    • Principal Investigator
      TOKINO Takashi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Sapporo Medical University
  •  デジタル ゲノム スキャニング法の開発と胃癌関連遺伝子探索への応用Principal Investigator

    • Principal Investigator
      時野 隆至
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Sapporo Medical University
  •  Diagnostic and therapeutic application of cell-cycle checkpoint genes for oral squamous cell cancer.Principal Investigator

    • Principal Investigator
      TOKINO Takashi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Sapporo Medical University
  •  p53 family : function and cancer therapyPrincipal Investigator

    • Principal Investigator
      TOKINO Takashi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Sapporo Medical University
  •  p53遺伝子ファミリーの機能解析とがん治療への応用Principal Investigator

    • Principal Investigator
      時野 隆至
    • Project Period (FY)
      2005 – 2009
    • Research Institution
      Sapporo Medical University
  •  デジタルゲノムスキャニング法の開発と消化器癌関連遺伝子探索への応用Principal Investigator

    • Principal Investigator
      時野 隆至
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Sapporo Medical University
  •  p53転写制御因子ファミリーの細胞分化における役割

    • Principal Investigator
      佐々木 泰史
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Sapporo Medical University
  •  Diagnostic and therapeutic application of checkpoint gene CHFR in oral squamous cell cancer.Principal Investigator

    • Principal Investigator
      TOKINO Takashi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Sapporo Medical University
  •  遺伝子あるいは発現プロテオミクス解析を用いた婦人科癌抗癌剤耐性の分子標的の研究

    • Principal Investigator
      SAGAE Satoru
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Sapporo Medical University
  •  卵巣癌におけるエピジェネティクスの異常の解析と治療への応用についての研究

    • Principal Investigator
      藤井 美穂
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Sapporo Medical University
  •  転写制御因子p63の発生,分化における役割

    • Principal Investigator
      SASAKI Yasushi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Sapporo Medical University
  •  Investigation of causative gene of familial occurrence of idiopathic occlusion of Willis ring

    • Principal Investigator
      HOUKIN Kiyohiro
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Sapporo Medical University
  •  Function of p53 and its target genesPrincipal Investigator

    • Principal Investigator
      TOKINO Takashi
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Sapporo Medical University
  •  ヨーロッパなどががん研究先進国との研究交流

    • Principal Investigator
      黒木 登志夫
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Showa University
  •  罹患同胞対法を用いた胃がん関連遺伝子の解明

    • Principal Investigator
      笹月 健彦
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyushu University
  •  Functional analysis of p53-target genes.Principal Investigator

    • Principal Investigator
      TOKINO Takashi
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Sapporo Medical University
  •  Genetic analyses for DNA replication error, beta-catenin gene, SKT11 etc.among the patients with gynecologic cancer

    • Principal Investigator
      SAGAE Satoru
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Sapporo Medical University
  •  BAI1 expression in human glioma

    • Principal Investigator
      ARITA Norio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Hyogo Medical University
      Osaka University
  •  Positional cloning of carnitine trasporter gene and its comtribution to the pathophysiological changes

    • Principal Investigator
      KUWAJIMA Masamichi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      The University of Tokushima
  •  癌抑制遺伝子の単離とそのヒト癌における遺伝子異常の解明Principal Investigator

    • Principal Investigator
      時野 隆至, 中村 祐輔
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
      Japanese Foundation For Cancer Research
  •  がんの遺伝子診断

    • Principal Investigator
      珠玖 洋
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Mie University
  •  乳癌・大腸癌における癌抑制遺伝子の単離

    • Principal Investigator
      中村 祐輔
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research
  •  癌抑制遺伝子解析のためのヒト第3染色体遺伝的地図の作成および遺伝子の同定

    • Principal Investigator
      中村 祐輔
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Human genetics
    • Research Institution
      Japanese Foundation For Cancer Research
  •  DNA増幅法(PCR法)による高多型VNTRマ-カ-の単離Principal Investigator

    • Principal Investigator
      時野 隆至
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Japanese Foundation For Cancer Research

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] Clinical Genomicsを目指した半導体NGSによるがんゲノム解析. 実験医学32(11)2014

    • Author(s)
      丸喜明、佐々木泰史、中村友紀、横井左奈、大平美紀、時野隆至、永瀬浩喜
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Long Noncoding RNA RP11-278A23.1, a Potential Modulator of p53 Tumor Suppression, Contributes to Colorectal Cancer Progression2024

    • Author(s)
      Kamikokura Masayo、Tange Shoichiro、Nakase Hiroshi、Tokino Takashi、Idogawa Masashi
    • Journal Title

      Cancers

      Volume: 16 Issue: 5 Pages: 882-882

    • DOI

      10.3390/cancers16050882

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07173
  • [Journal Article] <i>LMNA::NTRK1</i> Fusion-positive Leiomyosarcoma: Discrepancy between DNA-based Comprehensive Genomic Profiling and RNA Sequencing2024

    • Author(s)
      Suzuki Norito、Idogawa Masashi、Emori Makoto、Murase Kazuyuki、Arihara Yohei、Nakamura Hajime、Usami Makoto、Kubo Tomohiro、Kinoshita Ichiro、Sugita Shintaro、Tokino Takashi、Hasegawa Tadashi、Sakurai Akihiro、Takada Kohichi
    • Journal Title

      Intern. Med.

      Volume: 63 Issue: 15 Pages: 2215-2219

    • DOI

      10.2169/internalmedicine.2879-23

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2024-08-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07173
  • [Journal Article] The Clinical Validity of Urinary Pellet DNA Monitoring for the Diagnosis of Recurrent Bladder Cancer2024

    • Author(s)
      Abe Masakazu、Hiraki Hayato、Tsuyukubo Takashi、Ono Sadahide、Maekawa Shigekatsu、Tamura Daichi、Yashima-Abo Akiko、Kato Renpei、Fujisawa Hiromitsu、Iwaya Takeshi、Park Woong-Yang、Idogawa Masashi、Tokino Takashi、Obara Wataru、Nishizuka Satoshi S.
    • Journal Title

      The Journal of Molecular Diagnostics

      Volume: 26 Issue: 4 Pages: 278-291

    • DOI

      10.1016/j.jmoldx.2024.01.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07173, KAKENHI-PROJECT-22K09457, KAKENHI-PROJECT-21K07223
  • [Journal Article] The frequency and pathogenicity of BRCA1 and BRCA2 variants in the general Japanese population2024

    • Author(s)
      Idogawa Masashi、Mariya Tasuku、Tanaka Yumi、Saito Tsuyoshi、Nakase Hiroshi、Tokino Takashi、Sakurai Akihiro
    • Journal Title

      Journal of Human Genetics

      Volume: - Issue: 5 Pages: 225-230

    • DOI

      10.1038/s10038-024-01233-w

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K07173, KAKENHI-PROJECT-20K16363
  • [Journal Article] TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells2023

    • Author(s)
      Kitajima Hiroshi、Maruyama Reo、Niinuma Takeshi、Yamamoto Eiichiro、Takasawa Akira、Takasawa Kumi、Ishiguro Kazuya、Tsuyada Akihiro、Suzuki Ryo、Sudo Gota、Kubo Toshiyuki、Idogawa Masashi、Toyota Mutsumi、Yoshido Ayano、Kumegawa Kohei、Kai Masahiro、Tokino Takashi、Osanai Makoto、Nakase Hiroshi、Suzuki Hiromu
    • Journal Title

      Cell Death &amp; Disease

      Volume: 14 Issue: 7 Pages: 424-424

    • DOI

      10.1038/s41419-023-05953-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K16001, KAKENHI-PROJECT-21K07130, KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-22K07173, KAKENHI-PROJECT-23K06426, KAKENHI-PROJECT-23K06445, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K24186
  • [Journal Article] Effects of temozolomide on tumor mutation burden and microsatellite instability in melanoma cells2023

    • Author(s)
      Sawada Masahide、Hida Tokimasa、Kamiya Takafumi、Minowa Tomoyuki、Kato Junji、Okura Masae、Idogawa Masashi、Tokino Takashi、Uhara Hisashi
    • Journal Title

      The Journal of Dermatology

      Volume: 51 Issue: 3 Pages: 409-418

    • DOI

      10.1111/1346-8138.16925

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K07173
  • [Journal Article] MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway2023

    • Author(s)
      Tange S, Hirano T, Idogawa M, Hirata E, Imoto I, Tokino T
    • Journal Title

      BMC Cancer

      Volume: 23 Issue: 1 Pages: 85-85

    • DOI

      10.1186/s12885-022-10433-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K10146, KAKENHI-PROJECT-22K07173, KAKENHI-PROJECT-20H03510, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372
  • [Journal Article] Individualized circulating tumor <scp>DNA</scp> monitoring in head and neck squamous cell carcinoma2022

    • Author(s)
      Kogo Ryunosuke、Manako Tomomi、Iwaya Takeshi、Nishizuka Satoshi、Hiraki Hayato、Sasaki Yasushi、Idogawa Masashi、Tokino Takashi、Koide Ayaka、Komune Noritaka、Yasumatsu Ryuji、Nakagawa Takashi
    • Journal Title

      Cancer Medicine

      Volume: - Issue: 21 Pages: 3960-3968

    • DOI

      10.1002/cam4.4726

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-21K09561, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-20K09757, KAKENHI-PROJECT-19K08372, KAKENHI-PROJECT-20K09064
  • [Journal Article] Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma2022

    • Author(s)
      Murai Hiroki、Kodama Takahiro、Maesaka Kazuki、Tanaka Satoshi、Mita Eiji、Ohkawa Kazuyoshi、Hikita Hayato、Sakamori Ryotaro、Tatsumi Tomohide、Eguchi Hidetoshi、Morii Eiichi、Takehara Tetsuo
    • Journal Title

      Hepatology

      Volume: 77 Issue: 1 Pages: 77-91

    • DOI

      10.1002/hep.32573

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07894, KAKENHI-PROJECT-22K07173, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-19K07426, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372
  • [Journal Article] DLEU1 promotes oral squamous cell carcinoma progression by activating interferon-stimulated genes2021

    • Author(s)
      Hatanaka Yui、Niinuma Takeshi、Kitajima Hiroshi、Nishiyama Koyo、Maruyama Reo、Ishiguro Kazuya、Toyota Mutsumi、Yamamoto Eiichiro、Kai Masahiro、Yorozu Akira、Sekiguchi Shohei、Ogi Kazuhiro、Dehari Hironari、Idogawa Masashi、Sasaki Yasushi、Tokino Takashi、Miyazaki Akihiro、Suzuki Hiromu
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 20438-20438

    • DOI

      10.1038/s41598-021-99736-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K19239, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372, KAKENHI-PROJECT-19K10337, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-21K07130, KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-21K16846
  • [Journal Article] Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo2021

    • Author(s)
      Tanimizu Naoki、Ichinohe Norihisa、Sasaki Yasushi、Itoh Tohru、Sudo Ryo、Yamaguchi Tomoko、Katsuda Takeshi、Ninomiya Takafumi、Tokino Takashi、Ochiya Takahiro、Miyajima Atsushi、Mitaka Toshihiro
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 3390-3401

    • DOI

      10.1038/s41467-021-23575-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21908, KAKENHI-PROJECT-19H04452, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-20K05843, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-21H02518
  • [Journal Article] Dead or alive? Pitfall of survival analysis with TCGA datasets2021

    • Author(s)
      Idogawa Masashi、Koizumi Masayo、Hirano Tomomi、Tange Shoichiro、Nakase Hiroshi、Tokino Takashi
    • Journal Title

      Cancer Biology &amp; Therapy

      Volume: 22 Issue: 10-12 Pages: 527-528

    • DOI

      10.1080/15384047.2021.1979845

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07645
  • [Journal Article] Genetic analyses of a secondary poroma and trichoblastoma in a HRAS-mutated sebaceous nevus2021

    • Author(s)
      Minowa, Tomoyuki ; Kamiya, Takafumi ; Hida, Tokimasa ; Okura, Masae ; Kato, Junji ; Idogawa, Masashi ; Tange, Shoichiro ; Hirano, Tomomi ; Tokino, Takashi ; Uhara, Hisashi,
    • Journal Title

      J Dermatol

      Volume: 48 Issue: 8 Pages: 1268-1272

    • DOI

      10.1111/1346-8138.15919

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372
  • [Journal Article] Early dynamics of circulating tumor DNA predict chemotherapy responses for patients with esophageal cancer2021

    • Author(s)
      Ryosuke Fujisawa , Takeshi Iwaya, Fumitaka Endo, Masashi Idogawa, Noriyuki Sasaki, Hayato Hiraki, Shoichiro Tange, Tomomi Hirano, Yuka Koizumi , Masakazu Abe, Tomoko Takahashi, Mizunori Yaegashi , Yuji Akiyama, Mari Masuda, Akira Sasaki, Fumiaki Takahashi, Yasushi Sasaki, Takashi Tokino, Satoshi S Nishizuka
    • Journal Title

      Carcinogenesis

      Volume: 42(10) Issue: 10 Pages: 1239-1249

    • DOI

      10.1093/carcin/bgab088

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09224, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372, KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-20K09064, KAKENHI-PROJECT-16H06279
  • [Journal Article] ALK-positive atypical Spitz tumour with conspicuous rosette-like structures2021

    • Author(s)
      Minowa Tomoyuki、Hida Tokimasa、Horimoto Kohei、Kato Junji、Kamiya Takafumi、Sugita Shintaro、Idogawa Masashi、Saida Toshiaki、Hasegawa Tadashi、Tokino Takashi、Uhara Hisashi
    • Journal Title

      European Journal of Dermatology

      Volume: 31 Issue: 2 Pages: 256-258

    • DOI

      10.1684/ejd.2021.3997

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372
  • [Journal Article] Mutation Analysis of Radioresistant Early-Stage Cervical Cancer2021

    • Author(s)
      Oike Tae、Sekiguchi Yoshihito、Yoshimoto Yuya、Oike Takahiro、Ando Ken、Gu Wenchao、Sasaki Yasushi、Tokino Takashi、Iwase Akira、Ohno Tatsuya
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 1 Pages: 51-51

    • DOI

      10.3390/ijms23010051

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-16H06279
  • [Journal Article] Frequent Tumor Burden Monitoring of Esophageal Squamous Cell Carcinoma With Circulating Tumor DNA Using Individually Designed Digital Polymerase Chain Reaction2021

    • Author(s)
      Iwaya Takeshi、Endo Fumitaka、Takahashi Fumiaki、Tokino Takashi、Sasaki Yasushi、Nishizuka Satoshi S.
    • Journal Title

      Gastroenterology

      Volume: 160 Issue: 1 Pages: 463-465

    • DOI

      10.1053/j.gastro.2020.09.035

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K09224, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-20K09064
  • [Journal Article] Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum2020

    • Author(s)
      Nakanishi, H. Sawada, T. Kaizaki, Y. Ota, R. Suzuki, H. Yamamoto, E. Aoki, H. Eizuka, M. Hasatani, K. Takahashi, N. Inagaki, S. Ebi, M. Kato, H. Kubota, E. Kataoka, H. Takahashi, S. Tokino, T. Minamoto, T. Sugai, T. Sasaki, Y.
    • Journal Title

      PLoS One

      Volume: 15 Issue: 2 Pages: e0229262-e0229262

    • DOI

      10.1371/journal.pone.0229262

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-17K09374, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-20K07412, KAKENHI-PROJECT-20K16225, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K19577, KAKENHI-PROJECT-19H03727
  • [Journal Article] Mutation profiling of uterine cervical cancer patients treated with definitive radiotherapy2020

    • Author(s)
      Yoshimoto Yuya、Sasaki Yasushi、Murata Kazutoshi、Noda Shin-ei、Miyasaka Yuhei、Hamamoto Junko、Furuya Mio、Hirato Junko、Suzuki Yoshiyuki、Ohno Tatsuya、Tokino Takashi、Oike Takahiro、Nakano Takashi
    • Journal Title

      Gynecologic Oncology

      Volume: 159 Issue: 2 Pages: 546-553

    • DOI

      10.1016/j.ygyno.2020.08.020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07685, KAKENHI-PROJECT-18K07767, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-16H05388, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-16H06279
  • [Journal Article] Genetic analyses of mosaic neurofibromatosis type 1 with giant caf?‐au‐lait macule, plexiform neurofibroma and multiple melanocytic nevi2020

    • Author(s)
      Hida Tokimasa、Idogawa Masashi、Okura Masae、Sugita Shintaro、Sugawara Taro、Sasaki Yasushi、Tokino Takashi、Yamashita Toshiharu、Uhara Hisashi
    • Journal Title

      The Journal of Dermatology

      Volume: 47 Issue: 6 Pages: 658-662

    • DOI

      10.1111/1346-8138.15327

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372, KAKENHI-PROJECT-17K09354
  • [Journal Article] Aggressive variant of splenic marginal zone lymphoma characterized using a cancer panel test and treated with rituximab-containing chemotherapy2020

    • Author(s)
      Ishiguro Kazuya、Sasaki Yasushi、Takagi Yoshitake、Niinuma Takeshi、Suzuki Hiromu、Tokino Takashi、Hayashi Toshiaki、Takahashi Tohru、Igarashi Tetsuyuki、Matsuno Yoshihiro
    • Journal Title

      Medicine

      Volume: 99 Issue: 35 Pages: e21938-e21938

    • DOI

      10.1097/md.0000000000021938

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-17K09354
  • [Journal Article] Combination of KRAS and SMAD4 mutations in formalin‐fixed paraffin‐embedded tissues as a biomarker for pancreatic cancer2020

    • Author(s)
      Yokose Takahiro、Kitago Minoru、Matsuda Sachiko、Sasaki Yasushi、Masugi Yohei、Nakamura Yuki、Shinoda Masahiro、Yagi Hiroshi、Abe Yuta、Oshima Go、Hori Shutaro、Yusuke Fujita、Nakano Yutaka、Endo Yutaka、Abe Kodai、Tokino Takashi、Kitagawa Yuko
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 6 Pages: 2174-2182

    • DOI

      10.1111/cas.14425

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K08552, KAKENHI-PROJECT-16H06279
  • [Journal Article] Pathogenesis of multiple pancreatic cancers involves multicentric carcinogenesis and intrapancreatic metastasis2020

    • Author(s)
      Fujita, Y. Matsuda, S. Sasaki, Y. Masugi, Y. Kitago, M. Yagi, H. Abe, Y. Shinoda, M. Tokino, T. Sakamoto, M. Kitagawa, Y.
    • Journal Title

      Cancer Sci

      Volume: 111 Issue: 2 Pages: 739-748

    • DOI

      10.1111/cas.14268

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-18K15094, KAKENHI-PROJECT-16H06279
  • [Journal Article] Whole-exome sequencing of 79 xenografts as a potential approach for the identification of genetic variants associated with sensitivity to cytotoxic anticancer drugs2020

    • Author(s)
      Udagawa Chihiro、Sasaki Yasushi、Tanizawa Yasuhiro、Suemizu Hiroshi、Ohnishi Yasuyuki、Nakamura Yasukazu、Tokino Takashi、Zembutsu Hitoshi
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 9 Pages: e0239614-e0239614

    • DOI

      10.1371/journal.pone.0239614

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-16H06279
  • [Journal Article] Interactive Web-based Graphs of Coronavirus Disease 2019 Cases and Deaths per Population by Country2020

    • Author(s)
      Idogawa Masashi、Tange Shoichiro、Nakase Hiroshi、Tokino Takashi
    • Journal Title

      Clinical Infectious Diseases

      Volume: 71 Issue: 15 Pages: 902-903

    • DOI

      10.1093/cid/ciaa500

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07645
  • [Journal Article] Neurofibromatosis type 1 without cutaneous neurofibromas: a rare genotype-phenotype correlation?2020

    • Author(s)
      Hida Tokimasa、Idogawa Masashi、Ishikawa Aki、Mizukami Miyako、Kato Junji、Sumikawa Yasuyuki、Okura Masae、Tokino Takashi、Uhara Hisashi
    • Journal Title

      European Journal of Dermatology

      Volume: 30 Issue: 5 Pages: 608-609

    • DOI

      10.1684/ejd.2020.3861

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07645
  • [Journal Article] Integrated genetic and epigenetic analysis of cancer‐related genes in non‐ampullary duodenal adenomas and intramucosal adenocarcinomas2020

    • Author(s)
      Ota R、Sawada T、Tsuyama S、Sasaki Y、Suzuki H、Kaizaki Y、Hasatani K、Yamamoto E、Nakanishi H、Inagaki S、Tsuji S、Yoshida N、Doyama H、Minato H、Nakamura K、Kasashima S、Kubota E、Kataoka H、Tokino T、Yao T、Minamoto T
    • Journal Title

      The Journal of Pathology

      Volume: 252 Issue: 3 Pages: 330-342

    • DOI

      10.1002/path.5529

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08463, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-19H03727
  • [Journal Article] p53-induced ARVCF modulates the splicing landscape and supports the tumor suppressive function of p532020

    • Author(s)
      Suzuki, N. Idogawa, M. Tange, S. Ohashi, T. Sasaki, Y. Nakase, H. Tokino, T.
    • Journal Title

      Oncogene

      Volume: 39 Issue: 10 Pages: 2202-2211

    • DOI

      10.1038/s41388-019-1133-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-16K07122
  • [Journal Article] Chemotherapy after progression on nivolumab is essential for responders with genetic alterations of driver gene: Review of two recurrent/metastatic oral squamous cell carcinoma patients2020

    • Author(s)
      Ogi, K. Kobayashi, J. Nakagaki, T. Okamoto, J. Koike, K. Hirokawa, N. Someya, M. Sakamoto, H. Takada, K. Tokino, T. Sasaki, Y. Hiratsuka, H. Miyazaki, A.
    • Journal Title

      Oral Oncol

      Volume: 102 Pages: 104509-104509

    • DOI

      10.1016/j.oraloncology.2019.104509

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K10292, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-20K08390
  • [Journal Article] A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors2019

    • Author(s)
      Fukamachi H、Kim SK、Koh J、Lee HS、Sasaki Y、Yamashita K、Nishikawaji T、Shimada S、Akiyama Y、Byeon SJ、Bae DH、Okuno K、Nakagawa M、Tanioka T、Inokuchi M、Kawachi H、Tsuchiya K、Kojima K、Tokino Takashi、Eishi Y、Kim YS、Kim WH、Yuasa Y、Tanaka S
    • Journal Title

      Journal of Experimental & Clinical Cancer Research

      Volume: 38 Issue: 1 Pages: 127-127

    • DOI

      10.1186/s13046-019-1121-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K08647, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K19575, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-15K06832, KAKENHI-PROJECT-16H06279
  • [Journal Article] Renal angiomyolipoma (AML) harboring a missense mutation of TSC2 with copy-neutral loss of heterozygosity (CN-LOH)2019

    • Author(s)
      Idogawa Masashi、Hida Tokimasa、Tanaka Toshiaki、Ohira Noriaki、Tange Shoichiro、Sasaki Yasushi、Uhara Hisashi、Masumori Naoya、Tokino Takashi、Natori Hiroshi
    • Journal Title

      Cancer Biology & Therapy

      Volume: 21 Issue: 4 Pages: 315-319

    • DOI

      10.1080/15384047.2019.1702406

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-19K08372
  • [Journal Article] Genomic characterization for familial cases with urothelial carcinoma2019

    • Author(s)
      Shindo T, Hirobe M, Adachi Y, Sasaki Y, Tokino T, Masumori N
    • Journal Title

      Int Cancer Conf J

      Volume: 8 Issue: 4 Pages: 185-189

    • DOI

      10.1007/s13691-019-00381-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-16K07122
  • [Journal Article] Prognostic Effect of Long Noncoding RNA NEAT1 Expression Depends on p53 Mutation Status in Cancer2019

    • Author(s)
      Idogawa, M. Nakase, H. Sasaki, Y. Tokino, T.
    • Journal Title

      J Oncol

      Volume: 1 Pages: 4368068-4368068

    • DOI

      10.1155/2019/4368068

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285
  • [Journal Article] UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells2019

    • Author(s)
      Niinuma Takeshi、Kitajima Hiroshi、Kai Masahiro、Yamamoto Eiichiro、Yorozu Akira、Ishiguro Kazuya、Sasaki Hajime、Sudo Gota、Toyota Mutsumi、Hatahira Tomo、Maruyama Reo、Tokino Takashi、Nakase Hiroshi、Sugai Tamotsu、Suzuki Hiromu
    • Journal Title

      Clinical Epigenetics

      Volume: 11 Issue: 1 Pages: 70-70

    • DOI

      10.1186/s13148-019-0668-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-19K17468, KAKENHI-PROJECT-19K18736, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K08700
  • [Journal Article] FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy2019

    • Author(s)
      Darwis, N. D. M. Nachankar, A. Sasaki, Y. Matsui, T. Noda, S. E. Murata, K. Tamaki, T. Ando, K. Okonogi, N. Shiba, S. Irie, D. Kaminuma, T. Kumazawa, T. Anakura, M. Yamashita, S. Hirakawa, T. Kakoti, S. Hirota, Y. Tokino, T. Iwase, A. Ohno, T. Shibata, A. Oike, T. Nakano, T.
    • Journal Title

      Int J Mol Sci

      Volume: 20 Issue: 18 Pages: 4563-4563

    • DOI

      10.3390/ijms20184563

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K11130, KAKENHI-PROJECT-17H04713, KAKENHI-PROJECT-16H05388
  • [Journal Article] DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling2018

    • Author(s)
      Ishiguro Kazuya、Kitajima Hiroshi、Niinuma Takeshi、Ishida Tadao、Maruyama Reo、Ikeda Hiroshi、Hayashi Toshiaki、Sasaki Hajime、Wakasugi Hideki、Nishiyama Koyo、Shindo Tetsuya、Yamamoto Eiichiro、Kai Masahiro、Sasaki Yasushi、Tokino Takashi、Nakase Hiroshi、Suzuki Hiromu
    • Journal Title

      Haematologica

      Volume: 104 Issue: 1 Pages: 155-165

    • DOI

      10.3324/haematol.2018.191262

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-17K15959, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19K17438, KAKENHI-PROJECT-19K17468, KAKENHI-PROJECT-19H03518
  • [Journal Article] Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma2018

    • Author(s)
      Nakagaki Takafumi、Tamura Miyuki、Kobashi Kenta、Omori Akina、Koyama Ryota、Idogawa Masashi、Ogi Kazuhiro、Hiratsuka Hiroyoshi、Tokino Takashi、Sasaki Yasushi
    • Journal Title

      Tumor Biology

      Volume: 40 Issue: 9 Pages: 0-0

    • DOI

      10.1177/1010428318800180

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-16H06279
  • [Journal Article] Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU12018

    • Author(s)
      Nishiyama K、Maruyama R、Niinuma T、Kai M、Kitajima H、Toyota M、Hatanaka Y、Igarashi T、Kobayashi J、Ogi K、Dehari H、Miyazaki A、Yorozu A、Yamamoto E、Idogawa M、Sasaki Y、Sugai T、Tokino Takashi、Hiratsuka H、Suzuki H
    • Journal Title

      Cell Death & Disease

      Volume: 9 Issue: 8 Pages: 826-826

    • DOI

      10.1038/s41419-018-0893-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-18K17174, KAKENHI-PROJECT-16K11729, KAKENHI-PROJECT-16H06279
  • [Journal Article] Targeted sequencing reveals genetic variants associated with sensitivity of 79 human cancer xenografts to anticancer drugs.2018

    • Author(s)
      Udagawa C, Sasaki Y, Suemizu H, Ohnishi H, Tokino T, Zembutsu H
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 15 Pages: 1339-1359

    • DOI

      10.3892/etm.2017.5533

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-16K18445, KAKENHI-PROJECT-16H06279
  • [Journal Article] Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors2018

    • Author(s)
      Harada T、Yamamoto E、Yamano HO、Aoki H、Matsushita HO、Yoshikawa K、Takagi R、Harada E、Tanaka Y、Yoshida Y、Eizuka M、Yorozu A、Sudo G、Kitajima H、Niinuma T、Kai M、Sasaki Y、Tokino Takashi、Sugai T、Nakase H、Suzuki H
    • Journal Title

      Journal of Gastroenterology

      Volume: 53 Issue: 12 Pages: 1241-1252

    • DOI

      10.1007/s00535-018-1481-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-17K09387, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-17K15956, KAKENHI-PROJECT-16H06279
  • [Journal Article] Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy2018

    • Author(s)
      Nuryadi E、Sasaki Y、Hagiwara Y、Permata TBM、Sato H、Komatsu S、Yoshimoto Y、Murata K、Ando K、Kubo N、Okonogi N、Takakusagi Y、Adachi A、Iwanaga M、Tsuchida K、Tamaki T、Noda S、Hirota Y、Shibata A、Ohno T、Tokino Takashi、Oike T、Nakano T
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 66 Pages: 32642-32652

    • DOI

      10.18632/oncotarget.25982

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K07706, KAKENHI-PROJECT-15K09989, KAKENHI-PROJECT-16H06279
  • [Journal Article] Target amplicon exome-sequencing identifies promising diagnosis and prognostic markers involved in RTK-RAS and PI3K-AKT signaling as central oncopathways in primary central nervous system lymphoma2018

    • Author(s)
      Takashima Yasuo、Sasaki Yasushi、Hayano Azusa、Homma Jumpei、Fukai Junya、Iwadate Yasuo、Kajiwara Koji、Ishizawa Shin、Hondoh Hiroaki、Tokino Takashi、Yamanaka Ryuya
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 44 Pages: 27471-27486

    • DOI

      10.18632/oncotarget.25463

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K09001, KAKENHI-PROJECT-16H05441, KAKENHI-PROJECT-16K10766, KAKENHI-PROJECT-16H06279
  • [Journal Article] Epigenetic silencing of miR-200b is associated with cisplatin resistance in bladder cancer2018

    • Author(s)
      Shindo Tetsuya、Niinuma Takeshi、Nishiyama Naotaka、Shinkai Nobuo、Kitajima Hiroshi、Kai Masahiro、Maruyama Reo、Tokino Takashi、Masumori Naoya、Suzuki Hiromu
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 36 Pages: 24457-24469

    • DOI

      10.18632/oncotarget.25326

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-16K11017, KAKENHI-PROJECT-16H06279
  • [Journal Article] Dysregulation of miRNA in chronic hepatitis B is associated with hepatocellular carcinoma risk after nucleos(t)ide analogue treatment2018

    • Author(s)
      Wakasugi H, Takahashi H, Niinuma T, Kitajima H, Oikawa R, Matsumoto N, Takeba Y, Otsubo T, Takagi M, Ariizumi Y, Suzuki M, Okuse C, Iwabuchi S, Nakano M, Akutsu N, Kang JH, Matsui T, Yamada N, Sasaki H, Yamamoto E, Kai M, Sasaki Y, Sasaki, Tanaka, Yotsuyanagi, Tsutsumi, Yamamoto, Tokino T , Nakase H, Suzuki H, Itoh F
    • Journal Title

      Cancer Letters

      Volume: 434 Pages: 91-100

    • DOI

      10.1016/j.canlet.2018.07.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-17K15959
  • [Journal Article] p53 mediates the suppression of cancer cell invasion by inducing LIMA1/EPLIN.2017

    • Author(s)
      Tomoko Ohashi, Masashi Idogawa, Yasushi Sasaki, Takashi Tokino
    • Journal Title

      Cancer Letters

      Volume: 390 Pages: 58-66

    • DOI

      10.1016/j.canlet.2016.12.034

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16J05870, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-26460944
  • [Journal Article] Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing.2017

    • Author(s)
      Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima H, Ohashi T, Idogawa M, Ogi K, Hiratsuka H, Tokino T, Sasaki Y
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 35 Pages: 59113-59122

    • DOI

      10.18632/oncotarget.19262

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-16H06279
  • [Journal Article] Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function.2017

    • Author(s)
      Masashi Idogawa, Tomoko Ohashi, Yasushi Sasaki, Hiroshi Nakase, Takashi Tokino
    • Journal Title

      International Joural of Cancer

      Volume: 印刷中 Issue: 12 Pages: 2785-2791

    • DOI

      10.1002/ijc.30689

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16J05870, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K09354
  • [Journal Article] Fledglings in p53 signaling network.2017

    • Author(s)
      Tokino T, Idogawa M, Sasaki Y
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 34 Pages: 55768-55769

    • DOI

      10.18632/oncotarget.19229

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-26460944
  • [Journal Article] The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.2017

    • Author(s)
      Matsunaga Y, Adachi Y, Sasaki Y, Koide H, Motoya M, Nosho K, Takagi H, Yamamoto H, Sasaki S, Tokino T, Carbone DP, Imai K, Shinomura Y
    • Journal Title

      Molecular Carcinogenesis

      Volume: VOL. 56 Issue: 2 Pages: 515-526

    • DOI

      10.1002/mc.22513

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
  • [Journal Article] Assessment of the quality of DNA from various formalin-fixed paraffin-embedded (FFPE) tissues and the use of this DNA for next-generation sequencing (NGS) with no artifactual mutation.2017

    • Author(s)
      Einaga N, Yoshida A, Noda H, Suemitsu M, Nakayama Y, Sakurada A, Kawaji Y, Yamaguchi H, Sasaski Y, Tokino T, Esumi M
    • Journal Title

      PLoS One

      Volume: 12 Issue: 5 Pages: e0176280-e0176280

    • DOI

      10.1371/journal.pone.0176280

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-16H06279
  • [Journal Article] Downregulation of miR-186 is associated with metastatic recurrence of gastrointestinal stromal tumors.2017

    • Author(s)
      Niinuma T, Kai M, Kitajima H, Yamamoto E, Harada T, Maruyama R, Nobuoka T, Kanda T, Hasegawa T, Tokino T, Sugai T, Shimomura Y, Nakase H, Suzuki H
    • Journal Title

      Oncology Letters

      Volume: 14 Pages: 5703-5710

    • DOI

      10.3892/ol.2017.6911

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-17K09387, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-16H05419, KAKENHI-PROJECT-16K15600, KAKENHI-PROJECT-16K19352, KAKENHI-PROJECT-15K08973
  • [Journal Article] Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53.2017

    • Author(s)
      Koyama R, Tamura M, Nakagaki T, Ohashi T, Idogawa M, Suzuki H, Tokino T, Sasaki Y
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 12 Pages: 2413-2421

    • DOI

      10.1111/cas.13420

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-16H06279
  • [Journal Article] Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target.2016

    • Author(s)
      Sasaki Y, Tamura M, Takeda K, Ogi K, Nakagaki T, Koyama R, Idogawa M, Hiratsuka H, Tokino T
    • Journal Title

      Oncotarget

      Volume: VOL. 7 Issue: 38 Pages: 61426-61437

    • DOI

      10.18632/oncotarget.11366

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-26460944
  • [Journal Article] TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells.2016

    • Author(s)
      Kai M, Niinuma T, Kitajima H, Yamamoto E, Harada T, Aoki H, Maruyama R, Toyota M, Sasaki Y, Sugai T, Tokino T, Nakase H, Suzuki H.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 12 Pages: e0168281-e0168281

    • DOI

      10.1371/journal.pone.0168281

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-15K15584, KAKENHI-PROJECT-15K18431, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-26460944
  • [Journal Article] Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress2016

    • Author(s)
      Hiroshi Saijo, Yoshihiko Hirohashi, et al.
    • Journal Title

      Oncotarget

      Volume: 2;7(31) Issue: 31 Pages: 50043-50056

    • DOI

      10.18632/oncotarget.10571

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-26460944
  • [Journal Article] A genomic screen for long noncoding RNA genes epigenetically silenced by aberrant DNA methylation in colorectal cancer.2016

    • Author(s)
      Kumegawa K, Maruyama R, Yamamoto E, Ashida M, Kitajima H, Tsuyada A, Niinuma T, Kai M, Yamano HO, Sugai T, Tokino T, Shinomura Y, Imai K, Suzuki H.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 26699-26699

    • DOI

      10.1038/srep26699

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-15K15584, KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
  • [Journal Article] Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing2016

    • Author(s)
      Sasaki Y, Tamura M, Koyama R, Nakagaki T, Adachi Y, Tokino T.
    • Journal Title

      WORLD JOURNAL OF GASTROENTEROLOGY

      Volume: 22 Issue: 7 Pages: 2284-2293

    • DOI

      10.3748/wjg.v22.i7.2284

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-26460944
  • [Journal Article] One-dimensional sliding of p53 along DNA is accelerated in the presence of Ca(2+) or Mg(2+) at millimolar concentrations2015

    • Author(s)
      Murata A, Ito Y, Kashima R, Kanbayashi S, Nanatani K, Igarashi C, Okumura M, Inaba K, Tokino T, Takahashi S, Kamagata K
    • Journal Title

      JOURNAL OF MOLECULAR BIOLOGY

      Volume: 427 Issue: 16 Pages: 2663-2678

    • DOI

      10.1016/j.jmb.2015.06.016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25430115, KAKENHI-PUBLICLY-15H01626, KAKENHI-PLANNED-25104007, KAKENHI-PROJECT-15H04335, KAKENHI-PROJECT-13J04030, KAKENHI-PROJECT-26650045, KAKENHI-PROJECT-26840045, KAKENHI-PROJECT-26282213, KAKENHI-PUBLICLY-15H01625, KAKENHI-PLANNED-26116005
  • [Journal Article] A Screen for Epigenetically Silenced microRNA Genes in Gastrointestinal Stromal Tumors.2015

    • Author(s)
      Isosaka M, Niinuma T, Nojima M, Kai M, Yamamoto E, Maruyama R, Nobuoka T, Nishida T, Kanda T, Taguchi T, Hasegawa T, Tokino T, Hirata K, Suzuki H, Shinomura Y
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: e0133754-e0133754

    • DOI

      10.1371/journal.pone.0133754

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-15K15584, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-26640110, KAKENHI-PROJECT-26860514
  • [Journal Article] Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy2015

    • Author(s)
      Mitsuhashi K, Yamamoto I, Kurihara H, Kanno S, Ito M, Igarashi H, Ishigami K, Sukawa Y, Tachibana M, Takahashi H, Tokino T, Maruyama R, Suzuki H, Imai K, Shinomura Y, Yamamoto H, Nosho K
    • Journal Title

      ONCOTARGET

      Volume: 6 Issue: 26 Pages: 22114-22125

    • DOI

      10.18632/oncotarget.4294

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101
  • [Journal Article] Relation between Ku80 and microRNA-99a expression and late rectal bleeding after radiotherapy.2015

    • Author(s)
      Someya M, Yamamoto H, Nojima M, Hori M, Tateoka K, Nakata K, Takagi M, Saitoh M, Hirokawa N, Tokino T, Sakata K
    • Journal Title

      Radiotherapy and Oncology

      Volume: in press Issue: 2 Pages: 235-239

    • DOI

      10.1016/j.radonc.2015.04.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591845, KAKENHI-PROJECT-24591846, KAKENHI-PROJECT-25861114, KAKENHI-PROJECT-25430115
  • [Journal Article] Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing2015

    • Author(s)
      Ikeda H, Ishiguro K, Igarashi T, Aoki Y, Hayashi T, Ishida T, Sasaki Y, Tokino T, Shinomura Y.
    • Journal Title

      ONCOTARGETS AND THERAPY

      Volume: 8 Pages: 2805-2815

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25430115
  • [Journal Article] Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors2015

    • Author(s)
      Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H
    • Journal Title

      Oncotarget

      Volume: 6 Issue: 30 Pages: 29975-90

    • DOI

      10.18632/oncotarget.5034

    • NAID

      130005161526

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-15K15584, KAKENHI-PROJECT-15K18431, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-25460420, KAKENHI-PROJECT-26640101
  • [Journal Article] CRKL oncogene is downregulated by p53 through miR-200s2015

    • Author(s)
      Tamura M, Sasaki Y, Kobashi K, Takeda K, Nakagaki T, Idogawa M, Tokino T.
    • Journal Title

      CANCER SCIENCE

      Volume: 106 Issue: 8 Pages: 1033-1040

    • DOI

      10.1111/cas.12713

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-26460944
  • [Journal Article] Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells.2014

    • Author(s)
      Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T
    • Journal Title

      Oncotarget

      Volume: 5 Pages: 7540-7548

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25134715
  • [Journal Article] Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells.2014

    • Author(s)
      Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T
    • Journal Title

      Oncotarget

      Volume: 5 Pages: 7540-7548

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25430115
  • [Journal Article] MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions2014

    • Author(s)
      Ito M, Mitsuhashi K, Igarashi H, Nosho K, Yamamoto H
    • Journal Title

      Int J Cancer

      Volume: (Epub ahead of print) Issue: 11 Pages: 2507-2515

    • DOI

      10.1002/ijc.28920

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
  • [Journal Article] Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53-binding sites2014

    • Author(s)
      Idogawa M, Ohashi T, Sasaki Y, Maruyama R, Kashima L, Suzuki H, Tokino T
    • Journal Title

      Hum Mol Genet

      Volume: 23 Issue: 11 Pages: 2847-2857

    • DOI

      10.1093/hmg/ddt673

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-221S0001
  • [Journal Article] Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness2014

    • Author(s)
      Tamura M, Sasaki Y, Koyama R, Takeda K, Idogawa M, Tokino T
    • Journal Title

      Oncogene

      Volume: (in press) Issue: 40 Pages: 4837-4846

    • DOI

      10.1038/onc.2013.427

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-221S0001
  • [Journal Article] Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells2014

    • Author(s)
      Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T
    • Journal Title

      Oncotarget

      Volume: 5 Issue: 17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Clinical Genomicsを目指した半導体NGSによるがんゲノム解析2014

    • Author(s)
      丸喜明,佐々木泰史,中村友紀,横井左奈,大平美紀,時野隆至,永瀬浩喜
    • Journal Title

      実験医学(羊土社)

      Volume: 32 Pages: 1781-1788

    • Data Source
      KAKENHI-PUBLICLY-25134715
  • [Journal Article] Clinical Genomicsを目指した半導体NGSによるがんゲノム解析2014

    • Author(s)
      丸喜明,佐々木泰史,中村友紀,横井左奈,大平美紀,時野隆至,永瀬浩喜
    • Journal Title

      羊土社

      Volume: 32 Pages: 1781-1788

    • Data Source
      KAKENHI-PROJECT-25430115
  • [Journal Article] Methylation of a panel of microRNA genes is a novel biomarker for detection of bladder cancer2013

    • Author(s)
      Shimizu T, Suzuki H, Nojima M, Kitamura H, Yamamoto E, Maruyama R, Ashida M, Hatahira T, Kai M, Masumori N, Tokino T, Imai K, Tsukamoto T, Toyota M
    • Journal Title

      Eur Urol

      Volume: 63 Issue: 6 Pages: 1091-1100

    • DOI

      10.1016/j.eururo.2012.11.030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-221S0001
  • [Journal Article] DNA methyltransferase 1 is essential for initiation of the colon cancers2013

    • Author(s)
      Morita R,Hirohashi Y,Suzuki H, et al
    • Journal Title

      Experimental and Molecular Pathology

      Volume: 94 Issue: 2 Pages: 322-329

    • DOI

      10.1016/j.yexmp.2012.10.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J02959, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590427, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24590448, KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24791467, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115
  • [Journal Article] AKR1B10, a transcriptional target of p53, is Downregulated in Colorectal Cancers Associated with Poor Prognosis2013

    • Author(s)
      Ohashi T et al.
    • Journal Title

      Mol Cancer Res

      Volume: 11 Issue: 12 Pages: 1554-1163

    • DOI

      10.1158/1541-7786.mcr-13-0330-t

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929
  • [Journal Article] Aberrant Methylation of RASGRF1 Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer.2012

    • Author(s)
      Takamaru H, Yamamoto E, Suzuki H.
    • Journal Title

      Cancer Prev Res (Phila)

      Volume: 5(10) Issue: 10 Pages: 2012-2012

    • DOI

      10.1158/1940-6207.capr-12-0056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590317, KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632
  • [Journal Article] CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion2012

    • Author(s)
      Sasaki Y, Sugisaka J, Maruyama R, Sugisaka J, Tamura M, Sugisaka J, Suzuki H, Idogawa M, Shinomura Y, Tokino T
    • Journal Title

      Cancer Biol Ther

      Volume: 13 Issue: 14 Pages: 1512-1521

    • DOI

      10.4161/cbt.22280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
  • [Journal Article] CHFR regulates the mitotic checkpoint by targeting PARP-1 for ubiquitination and degradation2012

    • Author(s)
      Kashima, L., Idogawa, M., Mita, H., Shitashige, M., Yamada, T., Ogi, K., Suzuki, H., Toyota, M., Ariga, H., Sasaki, Y., Tokino, T.
    • Journal Title

      J. Biol. Chem

      Volume: 287 Issue: 16 Pages: 12975-12984

    • DOI

      10.1074/jbc.m111.321828

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390014, KAKENHI-PROJECT-22790654, KAKENHI-PROJECT-22791293, KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
  • [Journal Article] A novel approach to cancer treatment using structural hybrids of the p53 gene family.2012

    • Author(s)
      Sasaki Y, Oshima Y, Koyama R, Tamura M, Kashima L, Idogawa M, Yamashita T, Toyota M, Imai K, Shinomura Y, Tokino T.
    • Journal Title

      Cancer Gene Ther

      Volume: 19 Issue: 11 Pages: 749-56

    • DOI

      10.1038/cgt.2012.51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
  • [Journal Article] Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes2012

    • Author(s)
      Takahashi A, Torigoe T, Tamura Y, Kanaseki T, Tsukahara T, Sasaki Y, Kameshima H, Tsuruma T, Hirata K, Tokino T, Hirohashi Y, Sato N
    • Journal Title

      Cell Stress Chaperones

      Volume: 17 Issue: 6 Pages: 757-763

    • DOI

      10.1007/s12192-012-0348-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590427, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24590448, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24659592, KAKENHI-PROJECT-24791467
  • [Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors2012

    • Author(s)
      Takeshi Niinuma
    • Journal Title

      Cancer research

      Volume: 72 Issue: 5 Pages: 1126-36

    • DOI

      10.1158/0008-5472.can-11-1803

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632
  • [Journal Article] Genomic vulnerability to LINE-1 hypermethylation is a potential determinant of the clinicogenetic features of multiple myeloma.2012

    • Author(s)
      Aoki Y, Nojima M, Suzuki H, Yasui H, Maruyama R, Yamamoto E, Ashida M, Itagaki M, Asaoku H, Ikeda H, Hayashi T, Imai K, Mori M, Tokino T, Ishida T, Toyota M, Shinomura Y
    • Journal Title

      Genome Medicine

      Volume: (印刷中) Issue: 12

    • DOI

      10.1186/gm402

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24591402
  • [Journal Article] Genome-wide analysis of DNA methylation identifies novel cancer-related genes in hepatocellular carcinoma2012

    • Author(s)
      Shitani M, Sasaki S, Akutsu N, Takagi H, Suzuki H, Nojima M, Yamamoto H, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y
    • Journal Title

      Tumour Biol

      Volume: 33 Issue: 5 Pages: 1307-1317

    • DOI

      10.1007/s13277-012-0378-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659658
  • [Journal Article] Molecular Dissection of Premalignant Colorectal Lesions Reveals Early Onset of the CpG Island Methylator Phenotype.2012

    • Author(s)
      Yamamoto E, Suzuki H, Yamano HO
    • Journal Title

      Am J Pathol

      Volume: 181(5) Issue: 5 Pages: 1847-61

    • DOI

      10.1016/j.ajpath.2012.08.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590317, KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-23791283, KAKENHI-PROJECT-24650632
  • [Journal Article] Genome-wide profiling of chromatin signatures reveals epigenetic regulation of microRNA genes in colorectal cancer2011

    • Author(s)
      Suzuki H
    • Journal Title

      Cancer Res

      Volume: 71 Issue: 17 Pages: 5646-5658

    • DOI

      10.1158/0008-5472.can-11-1076

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300320, KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
  • [Journal Article] Cystein-rich intestinal protein 2 (CRIP2) acts as a repressor of NFkB-mediated pro-angiogenic cytokins transcription to suppress tumorigenesis and angiogenesis2011

    • Author(s)
      Cheung, K.L., 7名略, Suzuki, T., 4名略
    • Journal Title

      Proceeding of National Academy of Science USA

      Volume: 108 Issue: 20 Pages: 8390-8395

    • DOI

      10.1073/pnas.1101747108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659011, KAKENHI-PROJECT-22791293, KAKENHI-PUBLICLY-23113701, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23659658
  • [Journal Article] Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors2011

    • Author(s)
      Seiko Kamimae
    • Journal Title

      Cancer prevention research

      Volume: 4 Issue: 5 Pages: 674-83

    • DOI

      10.1158/1940-6207.capr-10-0214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
  • [Journal Article] p53 negatively regulates the hepatoma growth factor HDGF2011

    • Author(s)
      Sasaki Y, Negishi H, Idogawa M, Yokota I, Koyama R, Kusano M, Suzuki H, Fujita M, Maruyama R, Toyota M, Saito T, Tokino T
    • Journal Title

      Cancer Res

      Volume: 71 Issue: 22 Pages: 7038-47

    • DOI

      10.1158/0008-5472.can-11-1053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592141, KAKENHI-PROJECT-22790654, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
  • [Journal Article] IGFBP7 is a p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010

    • Author(s)
      Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa J-P J, Shinomura Y, Tokino T, Toyota M
    • Journal Title

      Carcinogenesis Vol.31, No.3

      Pages: 342-349

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae.2010

    • Author(s)
      Yamashita M, Toyota M, Suzuki H, Nojima M, Yamamoto E, Kamimae S, Watanabe Y, Kai M, Akashi H, Maruyama R, Sasaki Y, Yamano H, Sugai T, Shinomura Y, Imai K, Tokino T, Itoh F
    • Journal Title

      Cancer Sci Vol.101, No.7

      Pages: 1708-1716

    • NAID

      10026594987

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene.2010

    • Author(s)
      Yokota I, Sasaki Y, Kashima L, Idogawa M, Tokino T
    • Journal Title

      Int J Oncology Vol.37, No.6

      Pages: 1407-1416

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.2010

    • Author(s)
      Fujikane T, Nishikawa N, Toyota M, Suzuki H, Nojima M, Maruyama R, Ashida M, Ohe-Toyota M, Kai M, Nishidate T, Sasaki Y, Ohmura T, Hirata K, Tokino T
    • Journal Title

      Breast Cancer Res Treat Vol.122, No.3

      Pages: 699-710

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] IGFBP7 is a p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010

    • Author(s)
      Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa J-P J, Shinomura Y, Tokino T, Toyota M
    • Journal Title

      Carcinogenesis 31(3)

      Pages: 342-349

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] A novel correlation between LINE-1 hypomethylation and the malignancy of gastrointesrinal stromal tumors.2010

    • Author(s)
      Igarashi S, Suzuki H, Niinuma T, Nojima M, Iwaki H, Nobuoka T, Nishida T, Miyazaki Y, Takamaru H, Yamamoto E, Yamamoto H, Tokino T, Hasegawa T, Hirata K, Imai K, Toyota M, Shinomura Y
    • Journal Title

      Clin Cancer Res Vol.16, No.21

      Pages: 5114-5123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] A novel biomarker for cervical cancer.2009

    • Author(s)
      Tokino, Takashi
    • Journal Title

      Cancer Biology Therapy VOL.8

      Pages: 1154-1155

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] A novel biomarker for cervical cancer2009

    • Author(s)
      Tokino, Takashi
    • Journal Title

      Cancer Biology Therapy VOL.8

      Pages: 1154-1155

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659323
  • [Journal Article] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.2009

    • Author(s)
      Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Clin Cancer Res Vol.15, No.11

      Pages: 3725-3732

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] p53 family members regulate the expression of the apolipoprotein D gene.2009

    • Author(s)
      Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
    • Journal Title

      J Biol Chem Vol.284, No.2

      Pages: 872-883

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] Genomic Screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistence in multiple myeloma.2009

    • Author(s)
      Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
    • Journal Title

      Clinical Cancer Research 15(13)

      Pages: 4356-4364

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Genomic Screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistence in multiple myeloma.2009

    • Author(s)
      Nojima M, Maruyama R, Yasui H, Suzuki H,Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
    • Journal Title

      Clin Cancer Res1 Vol.15, No.13

      Pages: 4356-4364

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.2009

    • Author(s)
      Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Clinical Cancer Research 15(11)

      Pages: 3725-3732

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] A novel biomarker for cervical cancer.2009

    • Author(s)
      Tokino T
    • Journal Title

      Cancer Biology Therapy 8(12)

      Pages: 1154-1155

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Cancer epigenomics : Implications of DNA methylation in personalized cancer therapy.2009

    • Author(s)
      Toyota M, Suzuki H, Yamashita T, Hirata K, Imai K, Tokino T, Shinomura Y
    • Journal Title

      Cancer Sci Vol.100, No.5

      Pages: 787-791

    • NAID

      10025145027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] A novel biomarker for cervical cancer.2009

    • Author(s)
      Tokino T
    • Journal Title

      Cancer Biol Ther Vol.8, No.12

      Pages: 1154-1155

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] p53 family members regulate the expression of the apolipoprotein D gene.2009

    • Author(s)
      Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
    • Journal Title

      J Biol Chem 284(2)

      Pages: 872-883

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity.2009

    • Author(s)
      Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N
    • Journal Title

      Int J Cancer Vol.124, No.11

      Pages: 2607-2615

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers : involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth.2009

    • Author(s)
      Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kashima L, Yanagihara K, Fujita M, Hosokawa M, Kusano M, Sabau SV, Tatsumi H, Imai K, Shinomura Y, Tokino T
    • Journal Title

      BMC Cancer Vol.9, No.198(on line)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB.2009

    • Author(s)
      Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y, Tokino T
    • Journal Title

      Oncogene 28(29)

      Pages: 2643-2653

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity.2009

    • Author(s)
      Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N
    • Journal Title

      Int J Cancer 124(11)

      Pages: 2607-2615

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth.2009

    • Author(s)
      Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kashima L, Yanagihara K, Fujita M, Hosokawa M, Kusano M, Sabau SV, Tatsumi H, Imai K, Shinomura Y, Tokino T
    • Journal Title

      BMC Cancer 9

      Pages: 198-198

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB.2009

    • Author(s)
      Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y, Tokino T
    • Journal Title

      Oncogene Vol.28, No.29

      Pages: 2643-2653

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] Cancer epigenomics: Implications of DNA methylation in personalized cancer therapy.2009

    • Author(s)
      Toyota M, Suzuki H, Yamashita T, Hirata K, Imai K, Tokino T, Shinomura Y
    • Journal Title

      Cancer Science 100(5)

      Pages: 787-791

    • NAID

      10025145027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] A novel biomarker for cervical cancer2009

    • Author(s)
      Tokino, Takashi
    • Journal Title

      Cancer Biology Therapy VOL.8

      Pages: 1154-1155

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008

    • Author(s)
      Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M
    • Journal Title

      P h a r m a c o g e n o m i c s 9(12)

      Pages: 1917-1928

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008

    • Author(s)
      Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T
    • Journal Title

      C a n c e r R e s e a r c h 68(11)

      Pages: 4124-4132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Arequirment for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.2008

    • Author(s)
      Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
    • Journal Title

      Cancer Res Vol.68, No.8

      Pages: 2570-2575

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma.2008

    • Author(s)
      Sogabe Y, Suzuki H, Toyata M, Ogi K, Imai T, Nojima M, Sasaki Y, Hiratsuka H, Tokino T
    • Journal Title

      Int J Oncology Vol.32, No.6

      Pages: 1253-1261

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobactor pylori-related enlarged-fold gastritis.2008

    • Author(s)
      Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Muruyama R, Nojima M, Ashisa M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
    • Journal Title

      Cancer Epidemiol Biomarkers Prev Vol.17, No.10

      Pages: 2555-2564

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] A requirment for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.2008

    • Author(s)
      Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
    • Journal Title

      C a n c e r R e s e a r h 68(8)

      Pages: 2570-2575

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008

    • Author(s)
      Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Carcinogenesis Vol.29, No.7

      Pages: 1312-1318

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer.2008

    • Author(s)
      Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
    • Journal Title

      G a s t r o e n t e r o l o g y 135(1)

      Pages: 142-151

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobactor pylori-related enlarged-fold gastritis.2008

    • Author(s)
      Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Muruyama R, Nojima M, Ashisa M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
    • Journal Title

      C a n c e r E p i d e m i o l B i o m a r k e r s P r e v 17(10)

      Pages: 2555-2564

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer.2008

    • Author(s)
      Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
    • Journal Title

      Gastroenterology Vol.135, No.1

      Pages: 142-151

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] The histone deacetylase inhibitor FK228 enhances adenovirusmediated p53 family gene therapy in cancer models.2008

    • Author(s)
      Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
    • Journal Title

      M o l e c u l a r C a n c e r T h e r a p e u t i c s 7(4)

      Pages: 779-787

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008

    • Author(s)
      Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
    • Journal Title

      J Gastroenterol Vol.43, No.5

      Pages: 378-389

    • NAID

      10021268741

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008

    • Author(s)
      Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
    • Journal Title

      C a r c i n o g e n e s i s 29(7): 29(7)

      Pages: 1312-1318

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells.2008

    • Author(s)
      Kawasaki H, Mizuguchi T, Kikkawa Y, Oshima H, Sasaki Y, Tokino T, Kokai Y, Miyazaki J, Katsuramaki T, Mitaka T, Hirata K
    • Journal Title

      J H e p a t o b i l i a r y P a n c r e a t S u r g 15(3)

      Pages: 310-317

    • NAID

      10024157037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members.2008

    • Author(s)
      Sasaki Y, Oshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
    • Journal Title

      Mol Cancer Res Vol.6, No.3

      Pages: 395-406

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] The histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models.2008

    • Author(s)
      Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
    • Journal Title

      Mol Cancer Ther Vol.7, No.4

      Pages: 779-787

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008

    • Author(s)
      Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T
    • Journal Title

      C a n c e r S c i e n c e 99(5)

      Pages: 958-966

    • NAID

      10024006089

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma.2008

    • Author(s)
      Sogabe Y, Suzuki H, Toyata M, Ogi K, Imai T, Nojima M, Sasaki Y, Hiratsuka H, Tokino T
    • Journal Title

      I n t J O n c o l o g y 32(6)

      Pages: 1253-1261

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.2008

    • Author(s)
      Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T
    • Journal Title

      B r J C a n c e r 98(6)

      Pages: 1147-1156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008

    • Author(s)
      Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T.
    • Journal Title

      Cancer Res Vol.68, No.11

      Pages: 4124-4132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.2008

    • Author(s)
      Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T
    • Journal Title

      Br J Cancer Vol.98, No.6

      Pages: 1147-1156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008

    • Author(s)
      Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T
    • Journal Title

      Cancer Sci Vol.99, No.5

      Pages: 958-966

    • NAID

      10024006089

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells.2008

    • Author(s)
      Kawasaki H, Mizuguchi T, Kikkawa Y, Oshima H, Sasaki Y, Tokino T, Kokai Y, Miyazaki J, Katsuramaki T, Mitaka T, Hirata K
    • Journal Title

      J Hepatobiliary Pancreat Surg Vol.15, No.3

      Pages: 310-317

    • NAID

      10024157037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008

    • Author(s)
      Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
    • Journal Title

      J G a s t r o e n t e r o l 43(5)

      Pages: 378-389

    • NAID

      10021268741

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008

    • Author(s)
      Suzuki H, Tokino T, Shinomura Y,Imai K, Toyota M
    • Journal Title

      Pharmacogenomics Vol.9, No.12

      Pages: 1917-1928

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Journal Article] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members.2008

    • Author(s)
      Sasaki Y, Oshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
    • Journal Title

      M o l e c u l a r C a n c e r R e s 6(3)

      Pages: 395-406

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate betacatenine and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.2007

    • Author(s)
      Idogawa M, Masutani M, Shitashige M, Honda K, Tokino T, Shinomura, Imai K, Hirohashi S, Yamada T
    • Journal Title

      C a n c e r R e s e a r c h 67(3)

      Pages: 911-918

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.2007

    • Author(s)
      Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y
    • Journal Title

      C a r c i n o - g e n e s i s 28(12)

      Pages: 2459-2466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Gene Amplification and Overexpression of PRDM14 in Breast Cancers.2007

    • Author(s)
      Nishikawa N, Toyota M, Suzuki H, Honma T, Fujikane T, Ohmura T, Nishidate T, Ohe-Toyota M, Maruyama R, Sonoda T, Sasaki Y, Urano T, Imai K, Hirata K, Tokino T
    • Journal Title

      C a n c e r R e s e a r c h 67(20)

      Pages: 9649-9657

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007

    • Author(s)
      Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
    • Journal Title

      C a n c e r S c i e n c e 98(1)

      Pages: 88-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer.2007

    • Author(s)
      Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Tokino T
    • Journal Title

      C l i n i c a l C a n c e r R e s 13(16)

      Pages: 4786-4794

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007

    • Author(s)
      Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
    • Journal Title

      O n c o g e n e 26(32)

      Pages: 4699-4713

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Antitumor effect of adenovirusmediated p53 family gene transfer on osteosarcoma cell lines.2007

    • Author(s)
      Oshima Y, Sasaki Y, Negishi H, Toyota M, Yamashita T, Wada T, Nagoya S, Kawaguchi S, Yamashita T, Tokino T
    • Journal Title

      C a n c e r B i o l o g y T h e r a p y 6(7)

      Pages: 1058-1066

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Activation of the ribosomal protein L13 gene in human gastrointestinal cancer.2006

    • Author(s)
      Kobayashi T, Sasaki Y, Oshima Y, Yamamoto H, Mita H, Suzuki H, Toyota Y, Tokino T, Itoh F, Imai K, Shinomura Y
    • Journal Title

      I n t J M o l M e d 18(1)

      Pages: 161-170

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Implications for gene therapy treatment of human glioblastomas.2006

    • Author(s)
      Kang X, Xiao X, Harata M, Bai Y, Nakazaki Y, Soda Y, Kurita R, Tanaka T, Komine F, Izawa K, Kunisaki R, Setoyama M, Nishimori H, Natsume A, Sunamura M, Lozonshi L, Saitoh I, Tokino T, Asano S, Nakamura Y, Tani K: Antiangiogenic potency of BAI1 in vivo
    • Journal Title

      C a n c e r G e n e T h e r a p y 13(4)

      Pages: 385-392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinama.2006

    • Author(s)
      Okuda H, Toyota M, Ishida W, Furihata M, Tsuchiya M, Kamada M, Tokino T, Shuinn T
    • Journal Title

      O n c o g e n e 25(12)

      Pages: 1733-1742

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis2006

    • Author(s)
      King KE, Ponnamperuma RM, Gerdes MJ, Tokino T, Yamashita T, Baker CC, Weinberg WC
    • Journal Title

      C a r c i n o g e n e s i s 27(1)

      Pages: 53-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines.2006

    • Author(s)
      Terasawa K, Toyota M, Sagae S, Ogi K, Suzuki H, Sonoda T, Akino K, Maruyama R, Nishikawa N, Imai K, Shinohara Y, Saito T, Tokino T
    • Journal Title

      B r J C a n c e r 94(6)

      Pages: 914-921

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus.2006

    • Author(s)
      Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T
    • Journal Title

      C a n c e r 106(7)

      Pages: 1467-1479

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006

    • Author(s)
      Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
    • Journal Title

      C a n c e r R e s e a r c h 66(9)

      Pages: 4574-83

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] The role of T-fimbrin in the response to DNA damage: Silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents.2005

    • Author(s)
      Ikeda H, Sasaki Y, Kobayashi T, Suzuki H, Mita H, Toyota M, Itoh F, Shinomura Y, Tokino T, Imai K
    • Journal Title

      I n t J O n c o l 27(4)

      Pages: 933-40

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] The Ras effector RASSF2 is a novel tumor suppressor gene in human colorectal cancer.2005

    • Author(s)
      Akino K, Toyota M, Suzuki H, Mita H, Sasaki Y, Ohe-Toyota M, Issa J-P J, Hinoda Y, Imai K, Tokino T
    • Journal Title

      G a s t r o e n t e r o l o g y 129(1)

      Pages: 156-169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.2005

    • Author(s)
      Murai M, Toyota M, Satoh A, Suzuki H, Akino K, Mita H, Sasaki Y, Ishida T, Shen L, Garcia-Manero G, Issa JP, Hinoda Y, Tokino T, Imai K
    • Journal Title

      B r J C a n c e r 92(6)

      Pages: 1165-1172

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtuble inhibitors.2005

    • Author(s)
      Ogi K, Toyota M, Mita H, Satoh A, Kashima L, Sasaki Y, Suzuki H, Akino K, Nishikawa N, Shinomura Y, Imai K, Hiratsuka H, Tokino T
    • Journal Title

      C a n c e r B i o l o g y T h e r a p y 4(7)

      Pages: 773-780

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation.2005

    • Author(s)
      Simbulan-Rosethal CM, Trabosh V, Velarde A, Chou FP, Daher A, Tenzin F, Tokino T, Rosenthal DS
    • Journal Title

      O n c o g e n e 24(35)

      Pages: 5443-5458

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Identification of laminin b3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors.2005

    • Author(s)
      Irifune H, Nishimori H, Watanabe G, Yoshida K, Ikeda T, Matsui C, Morohashi M, Kawaguchi S, Nagoya S, Wada T, Yamashita T, Nakamura Y, Tokino T
    • Journal Title

      C a n c e r B i o l o g y T h e r a p y 4(4)

      Pages: 449-455

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Tight junction proteinMAGi-1 is up-regulated by tranfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis.2005

    • Author(s)
      Murata M, Kojima T, Yamamoto T, Go M, Takano K, Chiba H, Tokino T, Sawada N
    • Journal Title

      C e l l T i s s u e R e s 319(2)

      Pages: 341-347

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features.2005

    • Author(s)
      Odajima T, Sasaki Y, Tanaka N, Kato-Mori Y, Asanuma H, Ikeda T, Satoh M, Hiratsuka H, Tokino T, Sawada N
    • Journal Title

      H u m P a t h o l 36(3)

      Pages: 234-241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Enhanced Bax in oral SCC in relation to antitumor effects of chemotherapy.2005

    • Author(s)
      Takemura K, Noguchi M, Ogi K, Tokino T, Kubota H, Miyazaki A, Kohama G, Horatsuka H
    • Journal Title

      J O r a l P a t h o l M e d 34(2)

      Pages: 93-99

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Identification of pigment epithelium derived factor as a direct target of the p53 family member genes.2005

    • Author(s)
      Sasaki Y, Naishiro Y, Oshima Y, Imai K, Nakamura Y, Tokino T
    • Journal Title

      O n c o g e n e 24(32)

      Pages: 5131-5136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] A full genome scan for gastric cancer.2005

    • Author(s)
      AokiM,YamamuraY,NoshiroH,SakaiK,YokotaJ,KohnoT,TokinoT,IshidaS,OhyamaS,NinomiyaI,UesakaK,KitajimaM,ShimadaS,MatsunoS,YanoM,HiratsukaM,SugimuraH,ItohF,MinamotoT,MaeharaY,TakenoshitaS,AikouT,KataiH,Yoshimura K, TakahashiT,AkagiK,SairenjiM,YamamotoK,SasazukiT
    • Journal Title

      J M e d i c a l G e n e t i c s 42(1)

      Pages: 83-87

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Upregulation of BNIP3 by 5-aza-2 ' -deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.2005

    • Author(s)
      Abe T, Toyota M, Suzuki H, Murai M, Akino K, Ueno M, Nojima M, Yawata A, Miyakawa H, Suga T, Ito H, Endo T, Tokino T, Hinoda Y, Imai K
    • Journal Title

      J G a s t r o e n t e r o l 40(5)

      Pages: 504-510

    • NAID

      10015648191

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005

    • Author(s)
      Murai M, Toyota M, Suzuki H, Satoh A, Sasaki Y, Akino K, Ueno M, Takahashi F, Kusano M, Mita H, Yanagihara K, Endo T, Hinoda Y, Tokino T, Imai K
    • Journal Title

      C l i n i c a l C a n c e r R e s 11(3)

      Pages: 1021-1027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Dual roles of p53 in DNA binding.2004

    • Author(s)
      Tokino T et al.
    • Journal Title

      Cancer Biology Therapy 3-12

      Pages: 1322-1323

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390597
  • [Journal Article] Dual roles of p53 in DNA binding.2004

    • Author(s)
      Tokino T
    • Journal Title

      Cancer Biology Therapy 3・12

      Pages: 1322-1323

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390597
  • [Journal Article] Dual roles of p53 in DNA binding.

    • Author(s)
      Tokino T
    • Journal Title

      Cancer Biology & Therapy (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213115
  • [Journal Article] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.

    • Author(s)
      Fujikane T, Nishikawa N, Toyota M, Suzuki H, Nojima M, Maruyama R, Ashida M, Ohe-Toyota M, Kai M, Nishidate T, Sasaki Y, Ohmura T, Hirata K, Tokino T
    • Journal Title

      Breast Cancer Res Treat (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Journal Article] Dual roles of p53 in DNA binding.

    • Author(s)
      Tokino T
    • Journal Title

      Cancer Biology & Therapy (発表予定)

    • Data Source
      KAKENHI-PROJECT-16390597
  • [Journal Article] Dual roles of p53 in DNA binding.

    • Author(s)
      Tokino T
    • Journal Title

      Cancer Biology & Therapy (発表予定)

    • Data Source
      KAKENHI-PROJECT-12213115
  • [Patent] p53キメラ遺伝子を含む抗腫瘍剤2012

    • Inventor(s)
      時野 隆至
    • Industrial Property Rights Holder
      札幌医科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-187062
    • Filing Date
      2012-08-27
    • Data Source
      KAKENHI-PROJECT-23659658
  • [Patent] p53キメラ遺伝子を含む抗腫〓剤2012

    • Inventor(s)
      時野隆至、佐々木泰史、井戸川雅史
    • Industrial Property Rights Holder
      札幌医科大学
    • Filing Date
      2012-08-27
    • Data Source
      KAKENHI-PROJECT-23659658
  • [Presentation] 慢性胃炎および胃がんに関連する長鎖non-coding RNA結合タンパク質の探索2021

    • Author(s)
      北嶋洋志、丸山玲緒、山本英一郎、新沼 猛、甲斐正広、仲瀬裕志、時野隆至、鈴木 拓
    • Organizer
      第14回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Identification of a long non-coding RNA associated with gastritis and gastric cancer2021

    • Author(s)
      Hiroshi Kitajima, Reo Maruyama, Takeshi Niinuma, Akira Takasawa, Eiichiro Yamamoto, Kazuya Ishiguro, Masahiro Kai, Ayano Yoshido, Hiroshi Nakase, Takashi Tokino, Hiromu Suzuki
    • Organizer
      第22回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] A long non-coding RNA associated with chronic gastritis and gastric cancer promotes stress granule formation and inhibits apoptosis2021

    • Author(s)
      Hiroshi Kitajima, Reo Maruyama, Akira Takasawa, Takeshi Niinuma, Eiichiro Yamamoto, Kazuya Ishiguro, Ayano Yoshido, Masahiro Kai, Makoto Osanai, Takashi Tokino, Hiroshi Nakase, Hiromu Suzuki
    • Organizer
      39回札幌国際がんシンポジウム
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] 慢性胃炎・胃がん関連長鎖non-coding RNAはストレス顆粒形成を促進し、アポトーシスを抑制する2021

    • Author(s)
      北嶋洋志, 丸山玲緒, 新沼 猛, 山本英一郎, 高澤 啓, 石黒一也, 甲斐正広, 吉戸文乃, 小山内誠, 時野隆至, 仲瀬裕志, 鈴木 拓
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] A long non-coding RNA associated with chronic gastritis and gastric cancer inhibits apoptosis by promoting stress granule formation2021

    • Author(s)
      Hiroshi Kitajima, Reo Maruyama, Akira Takasawa, Takeshi Niinuma, Eiichiro Yamamoto, Kazuya Ishiguro, Ayano Yoshido, Masahiro Kai, Makoto Osanai, Takashi Tokino, Hiroshi Nakase, Hiromu Suzuki
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] 慢性胃炎・胃がん関連長鎖non-coding RNAによるストレス顆粒形成の促進と発がん機構の解析2021

    • Author(s)
      北嶋洋志, 丸山玲緒, 新沼 猛, 高澤 啓, 山本英一郎, 石黒一也, 甲斐正広, 吉戸文乃, 小山内誠, 時野隆至, 仲瀬裕志, 鈴木 拓
    • Organizer
      第101回北海道医学大会腫瘍系分科会・第123回北海道癌談話会例会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] メラノーマに特化したシーケンスパネルの開発2021

    • Author(s)
      肥田時征、堀本浩平、加藤潤史、佐藤さゆり、藤岡茉生、井戸川雅史、丹下正一朗、時野隆至、宇原 久
    • Organizer
      日本皮膚科学会北海道地方会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] 慢性胃炎および胃がんに関連する長鎖non-coding RNAの同定2020

    • Author(s)
      北嶋洋志、丸山玲緒、高澤 啓、新沼 猛、山本英一郎、甲斐正広、時野隆至、小山内誠、仲瀬裕志、鈴木 拓
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] 慢性胃炎および胃がんに関連する長鎖non-coding RNAの同定2020

    • Author(s)
      北嶋洋志、丸山玲緒、高澤 啓、新沼 猛、山本英一郎、甲斐正広、時野隆至、小山内誠、仲瀬裕志、鈴木 拓
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Targeted exome sequencing profiles genetic alterations in oral squamous cell carcinoma from Japanese patients.2019

    • Author(s)
      Sasaki Y, Nakagaki T, Tamura M, Fukushima F, Ikeda H, Koyama R, Idogawa M, Tokino T
    • Organizer
      American Association of Cancer Research (AACR) annual meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] The novel p53 family target BRMS1L suppresses cancer cell invasion and migration2019

    • Author(s)
      Sasaki Y, Koyama R, Maruyama R, Tamura M, Idogawa M, Suzuki H, Tokino T
    • Organizer
      11th AACR-JCA Joint International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Patient-specific circulating tumor DNA monitoring using esophageal squamous cell cancer gene panel and digital PCR2019

    • Author(s)
      Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Noriyuki Sasaki, Mizunori Yaegashi, Yuji Akiyama, Akira Sasaki, Mari Masuda, Tesshi Yamada, Takashi Tokino, Satoshi Nishizuka
    • Organizer
      アメリカ癌学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Amplicon-based targeted sequencing identifies promising markers in oral squamous cell carcinoma from Japanese patients.2019

    • Author(s)
      Takashi Tokino, Takafumi Nakagaki, Masashi Idogawa, Yasushi Sasaki.
    • Organizer
      11th AACR-JCA Joint International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Mutational Profiling of Japanese Cervical Cancer Patients Treated with Radiotherapy2019

    • Author(s)
      Yuya Yoshimoto, Takahiro Oike, Yasushi Sasaki, Endang Nuryadi, Kazutoshi Murata, Takuya Kaminuma, Daisuke Irie, Daijiro Kobayashi, Tatsuya Ohno, Takashi Tokino, Takashi Nakano
    • Organizer
      The 9th Annual Meeting of The International Society of Radiation Neurobiology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Epigenetic regulation of miR-200b is associated with cisplatin resistance in bladder cancer.2019

    • Author(s)
      Shindo T, Niinuma T, Kitajima H, Kai M, Tokino T, Masumori N, Suzuki H.
    • Organizer
      11th AACR-JCA Joint International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Patient-specific circulating tumor DNA monitoring using esophageal squamous cell cancer gene panel and digital PCR.2019

    • Author(s)
      Iwaya T, Endo F, Sasaki Y, Sasaki N, Yaegashi M, Akiyama Y, Sasaki A, Masuda M, Yamada T, Tokino T, Nishizuka S.
    • Organizer
      Amerian Association for Cancer Research (AACR)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] BRMSIL, a metastatic suppressor gene is transcriptionally regulated by p53.2019

    • Author(s)
      Takashi Tokino, Ryota Koyama, Masashi Idogawa, Yasushi Sasaki.
    • Organizer
      American Association of Cancer Research (AACR) Annual Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling.2019

    • Author(s)
      Ishiguro K, Kitajima H, Niinuma T, Ishida T, Maruyama R, Ikeda H, Yamamoto E, Kai M, Sasaki Y, Tokino T, Nakase H, Suzuki H.
    • Organizer
      11th AACR-JCA Joint International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Patient-specific circulating tumor DNA monitoring using digital PCR in esophageal squamous cell cancer patients.2018

    • Author(s)
      Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Mizunori Yaegashi, Kei Sato, Noriyuki Sasaki, Yuji Akiyama, Akira Sasaki, Mari Masuda, Takashi Tokino, Satoshi Nishizuka
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] 口腔扁平上皮癌のhotspot変異解析2018

    • Author(s)
      佐々木泰史、中垣貴文、田村みゆき、井戸川雅史、荻和弘、平塚博義、時野隆至
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Therapeutic response monitoring using digital PCR for patient-specific circulating tumor DNA identified by an esophageal squamous cell carcinoma-specific sequencing panel.2018

    • Author(s)
      Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Yuji Akiyama, Akira Sasaki, Mari Masuda, Tesshi Yamada, Takashi Tokino, Satoshi Nishizuka
    • Organizer
      米国臨床腫瘍学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] 口腔扁平上皮癌の全エクソン解析2017

    • Author(s)
      佐々木泰史, 田村みゆき, 中垣貴文, 小山良太, 井戸川雅史, 荻和弘, 平塚博義, 仲瀬裕志, 時野隆至
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Exploitation of a liquid biopsy system using circulating tumor DNA in esophageal cancer patients2017

    • Author(s)
      Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Mizunori Yaegashi, Takehiro Chiba, Yuji Akiyama, Mari Masuda, Tesshi Yamada, Takashi Tokino, Satoshi Nishizuka
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Profiling cancer-related gene alterations in Japanese multiple myeloma patients by targeted amplicon sequencing.2017

    • Author(s)
      Fukushima H, Sasaki Y, Tamura M, Ikeda H, Ishiguro K, Tokino T.
    • Organizer
      European Human Genetics Conference 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Targeted exome sequences of cancer-related genes in human cancers using amplicon sequencing.2017

    • Author(s)
      Sasaki Y, Nakagaki T, Tamura M, Fukushima H, Ikeda H, Koyama R, Idogawa M, Tokino T
    • Organizer
      American Association of Cancer Research(AACR, 米国癌学会)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing2017

    • Author(s)
      Sasaki Y, Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima F, Idogawa M, Ogi K, Hiratsuka H, Tokino T
    • Organizer
      The 12th International Workshop on Advanced Genomics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Mutation detection by target sequence analyses using tissue-specific panels in esophageal squamous cell carcinoma2017

    • Author(s)
      Takeshi Iwaya, Fumitaka Endo, Kohei Kume, Yasushi Sasaki, Takashi Tokino, Satoshi Nishizuka
    • Organizer
      アメリカ癌学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] Exome sequencing of cancer -related genes to identify genetic markers for sensitivity to cytotoxic anticancer drugs.2017

    • Author(s)
      Udagawa C, Sasaki Y, Suemizu H, Ohnishi Y, Ohnishi H, Tokino T, Zembutsu H.
    • Organizer
      American Association of Cancer Research(AACR, 米国癌学会)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06279
  • [Presentation] p53 downregulates CRKL oncogene through miR-200.2016

    • Author(s)
      Tokino T, Tamura M, Idogawa M, Sasaki Y
    • Organizer
      American Association of Cancer Research (AACR) annual meeting.
    • Place of Presentation
      New Orleans Convention Center, USA
    • Year and Date
      2016-04-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07122
  • [Presentation] p53 downregulates CRKL oncogene through miR-200.2016

    • Author(s)
      Tokino T, Tamura M, Idogawa M, Sasaki Y
    • Organizer
      American Association of Cancer Research (AACR) annuak meeting.
    • Place of Presentation
      New Orleans Convention Center, USA
    • Year and Date
      2016-04-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25430115
  • [Presentation] p53経路と発がん2016

    • Author(s)
      時野隆至
    • Organizer
      日本癌学会
    • Place of Presentation
      パシフィコ横浜,神奈川県横浜市
    • Year and Date
      2016-10-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-25430115
  • [Presentation] p53ネットワークとがん:最近の話題2015

    • Author(s)
      時野隆至
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-25430115
  • [Presentation] Genome-wide RNAi screening to identify shRNA that enhance p53-related apoptosis in human cancer cells2015

    • Author(s)
      Tokino T
    • Organizer
      SNUCRI Cancer Symposium
    • Place of Presentation
      Hwasun, Korea
    • Year and Date
      2015-04-01
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25430115
  • [Presentation] Genome-based personalized medicine in oncology.2014

    • Author(s)
      Tokino T
    • Organizer
      The 18th International Congress of Personalized Medicine.
    • Place of Presentation
      札幌
    • Year and Date
      2014-06-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-25430115
  • [Presentation] Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness.2014

    • Author(s)
      Tokino T, Tamura M, Idogawa M, Sasaki Y
    • Organizer
      American Association of Cancer Research (AACR) Annual Meeting.
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2014-04-06
    • Data Source
      KAKENHI-PROJECT-25430115
  • [Presentation] Genome-based personalized medicine in oncology2014

    • Author(s)
      Tokino T
    • Organizer
      The 18th International Congress of Personalized Medicine
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2014-06-14
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Presentation] Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53 binding sites.2014

    • Author(s)
      Idogawa M, Ohashi T, Sasaki Y, Tokino T
    • Organizer
      16th International p53 Workshop.
    • Place of Presentation
      Stockholm, Sweden.
    • Year and Date
      2014-06-17
    • Data Source
      KAKENHI-PUBLICLY-25134715
  • [Presentation] p53 family network and tumor suppression.2014

    • Author(s)
      Sasaki Y, Tamura, M, Takeda K, Idogawa M, Maruyama R, Suzuki H, Shinomura Y, Tokino T
    • Organizer
      The 3rd International Symposium on Genetic Regulation and Targeted Therapy of Cancer and 5th Symposium of A3 Foresight Program
    • Place of Presentation
      Zhangjiajie, China.
    • Year and Date
      2014-06-13
    • Data Source
      KAKENHI-PUBLICLY-25134715
  • [Presentation] Forkhead transcription factor FOXFI is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness2014

    • Author(s)
      Tokino T, Tamura M, Idogawa M, Sasaki Y
    • Organizer
      American Association of Cancer Research (AACR) Annual Meeting
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2014-04-06
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Presentation] Genome-based personalized medicine in oncology.2014

    • Author(s)
      Tokino T
    • Organizer
      The 18th International Congress of Personalized Medicine.
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2014-06-14
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25134715
  • [Presentation] Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness.2014

    • Author(s)
      Tokino T, Tamura M, Idogawa M, Sasaki Y
    • Organizer
      American Association of Cancer Research (AACR) Annual Meeting.
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2014-04-06
    • Data Source
      KAKENHI-PUBLICLY-25134715
  • [Presentation] p53 family network and tumor suppression.2014

    • Author(s)
      Sasaki Y, Tamura, M, Takeda K, Idogawa M, Maruyama R, Suzuki H, Shinomura Y, Tokino T
    • Organizer
      The 3rd International Symposium on Genetic Regulation and Targeted Therapy of Cancer and 5th Symposium of A3 Foresight Program
    • Place of Presentation
      Zhangjiajie, China.
    • Year and Date
      2014-06-13
    • Data Source
      KAKENHI-PROJECT-25430115
  • [Presentation] p53 family network and tumor suppression2014

    • Author(s)
      Sasaki Y, Tamura, M, Takeda K, Idogawa M, Maruyama R, Suzuki H, Shinomura Y, Tokino T
    • Organizer
      The 3rd International Symposium on Genetic Regulation and Targeted Therapy of Cancer and 5th Symposium of A3 Foresight Program
    • Place of Presentation
      Zhangjiajie, China
    • Year and Date
      2014-06-13
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Presentation] p53研究の新展開2012

    • Author(s)
      時野 隆至
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市教育文化会館(札幌)
    • Data Source
      KAKENHI-PROJECT-23659658
  • [Presentation] Identification of novel p53 target genes by ChIP-Seq and mRNA expression analysis combined with genome-wide p53-binding motif analysis in silico.2011

    • Author(s)
      Idogawa M, (Tokino T)
    • Organizer
      American Association of Cancer Research (AACR) Annual Meeting
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-04-03
    • Data Source
      KAKENHI-PROJECT-23659658
  • [Presentation] Apoptosis induction in cancer cells by the simultaneous transduction of p53 and artificial miRNAs based on the screening of genome-wide shRNA library2011

    • Author(s)
      Idogawa M, (Tokino T)
    • Organizer
      American Association of Cancer Research (AACR) Annual Meeting
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-04-03
    • Data Source
      KAKENHI-PROJECT-23659658
  • [Presentation] A comprehensive analysis to screen for epigenetically silenced miRNA genes in colorectal cancer2011

    • Author(s)
      Suzuki H, (Tokino T)
    • Organizer
      American Association of Cancer Research (AACR) Annual Meeting
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-04-03
    • Data Source
      KAKENHI-PROJECT-23659658
  • [Presentation] The functional relationship between CHFR and PARP-1 controls the antephase checkpoint and tumor development2011

    • Author(s)
      Kashima L, (Tokino T)
    • Organizer
      American Association of Cancer Research (AACR) Annual Meeting
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-04-03
    • Data Source
      KAKENHI-PROJECT-23659658
  • [Presentation] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB.2010

    • Author(s)
      Tokino T, Kashima L, Toyota M, Sasaki Y.
    • Organizer
      101th American Association of Cancer Research (AACR) Annual Meeting
    • Place of Presentation
      Washington DC, USA.
    • Year and Date
      2010-04-20
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Presentation] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB.2010

    • Author(s)
      Tokino, Takashi, et al
    • Organizer
      米国癌学会年会
    • Place of Presentation
      Convention Center, Wasgington, DC(米国)
    • Year and Date
      2010-04-20
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer.2010

    • Author(s)
      Tokino T, Idogawa M, Sasaki Y.
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association.
    • Place of Presentation
      Hawaii, USA.
    • Year and Date
      2010-02-09
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer2010

    • Author(s)
      Tokino, Takashi
    • Organizer
      8th Joint Conference of AACR and JCA
    • Place of Presentation
      Hilton Waikoloa Village(米国)
    • Year and Date
      2010-02-09
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer2010

    • Author(s)
      Tokino, Takashi
    • Organizer
      8th Joint Conference of AACR and JCA
    • Place of Presentation
      Hilton Waikoloa Village(米国)
    • Year and Date
      2010-02-09
    • Data Source
      KAKENHI-PROJECT-21659323
  • [Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer.2010

    • Author(s)
      Tokino, Takashi
    • Organizer
      8th Joint Conference of AACR and JCA
    • Place of Presentation
      Hilton Waikoloa Village(米国)
    • Year and Date
      2010-02-09
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer.2010

    • Author(s)
      Tokino T, Idogawa M, Sasaki Y.
    • Organizer
      8th AACR-JCA Joint International Conference.
    • Place of Presentation
      Waikoloa, Hawaii
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Presentation] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB.2010

    • Author(s)
      Tokino T, Kashima L, Toyota M, Sasaki Y.
    • Organizer
      101st American Association of Cancer Research (AACR) annual meeting.
    • Place of Presentation
      Washington D.C
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Presentation] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members.2008

    • Author(s)
      Tokino T, Sasaki Y.
    • Organizer
      99th American Association of Cancer Research (AACR) Annual Meeting.
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2008-04-14
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Presentation] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members.2008

    • Author(s)
      Tokino T, Sasaki Y.
    • Organizer
      American Association of Cancer Research (AACR) Annual meeting.
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2008

    • Author(s)
      時野隆至
    • Organizer
      米国癌学会年会
    • Place of Presentation
      米国ロサンゼルス
    • Year and Date
      2008-04-17
    • Data Source
      KAKENHI-PROJECT-19659344
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2008

    • Author(s)
      時野隆至
    • Organizer
      米国癌学会年会
    • Place of Presentation
      米国ロサンゼルス
    • Year and Date
      2008-04-17
    • Data Source
      KAKENHI-PROJECT-20390519
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines2008

    • Author(s)
      時野隆至
    • Organizer
      米国癌学会年会
    • Place of Presentation
      米国ロサンゼルス
    • Year and Date
      2008-04-17
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines2007

    • Author(s)
      Takashi, Tokino, et. al.
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      Los Angeles, CA
    • Year and Date
      2007-04-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390545
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2007

    • Author(s)
      Tokino T, Oshima Y, Yamashita T, Sasaki Y.
    • Organizer
      98th American Association of Cancer Research (AACR) Annual Meeting.
    • Place of Presentation
      Los Angeles, USA.
    • Year and Date
      2007-04-17
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines2007

    • Author(s)
      Takashi Tokino
    • Organizer
      米国癌学会年会
    • Place of Presentation
      ロサンゼルス
    • Year and Date
      2007-04-17
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390545
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2007

    • Author(s)
      時野 隆至
    • Organizer
      米国癌学会
    • Place of Presentation
      米国ロサンゼルス
    • Year and Date
      2007-04-17
    • Data Source
      KAKENHI-PROJECT-19659344
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines2007

    • Author(s)
      時野 隆至
    • Organizer
      米国癌学会
    • Place of Presentation
      米国ロサンゼルス
    • Year and Date
      2007-04-17
    • Data Source
      KAKENHI-PROJECT-17013702
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2007

    • Author(s)
      時野 隆至
    • Organizer
      米国癌学会(American Association of Cancer Research)
    • Place of Presentation
      米国ロサンゼルス
    • Year and Date
      2007-04-17
    • Data Source
      KAKENHI-PROJECT-18390545
  • [Presentation] Pigment epithelium derived factor as a direct target of the p53 family member genes.2006

    • Author(s)
      Tokino T, Sasaki Y.
    • Organizer
      97th American Association of Cancer Research (AACR) Annual Meeting.
    • Place of Presentation
      Washington DC, USA.
    • Year and Date
      2006-04-03
    • Data Source
      KAKENHI-PROJECT-17013072
  • [Presentation] Pigment epithelium derived factor as a direct target of the p53 family member genes2006

    • Author(s)
      Takashi Tokino
    • Organizer
      米国癌学会年会
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2006-04-03
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390545
  • [Presentation] Identification of laminin beta 3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumor.2005

    • Author(s)
      Tokino T, Irifune H, Sasaki Y, Yoshida K, Kawaguchi S, Wada T, Yamashita T.
    • Organizer
      96th American Association of Cancer Research (AACR) Annual Meeting.
    • Place of Presentation
      Anaheim, USA.
    • Year and Date
      2005-04-19
    • Data Source
      KAKENHI-PROJECT-17013072
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    # of Collaborated Products: 1 results
  • 246.  鈴木 孝浩
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