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Naito Mikihiko  内藤 幹彦

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NAITO Mikihiko  内藤 幹彦

内藤 幹彦

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Researcher Number 00198011
Other IDs
Affiliation (Current) 2025: 東京大学, 大学院薬学系研究科(薬学部), 特任教授
Affiliation (based on the past Project Information) *help 2020 – 2025: 東京大学, 大学院薬学系研究科(薬学部), 特任教授
2014 – 2019: 国立医薬品食品衛生研究所, 遺伝子医薬部, 部長
2011 – 2013: 国立医薬品食品衛生研究所, 機能生化学部, 部長
2009: National Institute of Health Sciences, 機能生化学部, 部長
2007 – 2008: The University of Tokyo, 分子細胞生物学研究所, 准教授 … More
2005 – 2006: 東京大学, 分子細胞生物学研究所, 助教授
1995 – 2003: 東京大学, 分子細胞生物学研究所, 助教授
1993 – 1995: 東京大学, 分子細胞生物学研究所, 助手
1994: 東京大学, 分子細胞生物研究所, 助手
1990 – 1993: 東京大学, 応用微生物研究所, 助手
1988: 癌研究会癌化学療法センター, 日本学術振興会, 特別研究員(がん) Less
Review Section/Research Field
Principal Investigator
Biological pharmacy / Biological Sciences / Biological pharmacy / Basic Section 50020:Tumor diagnostics and therapeutics-related / Transformative Research Areas, Section (III) / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Complex systems / Biological Sciences
Except Principal Investigator
Complex systems / Biological pharmacy
Keywords
Principal Investigator
ユビキチン / プロテアソーム / アポトーシス / SNIPER / Apollon / IAP / FLIP / PROTAC / タンパク質分解 / プロテインノックダウン … More / cIAP1 / 脱ユビキチン化酵素 / がん / ペプチド / 蛋白質 / エストロゲン受容体 / Apoxin / サイクリン / 核移行シグナル / ネクローシス / Nucleic acids / STAT3 / protein degradation / 融合タンパク質 / 血管新生 / セレブロン / デコイ核酸 / ステープルペプチド / セレブロンモジュレーター / ケミカルプロテインノックダウン / 固相合成 / アプタマーPROTAC / 神経変性疾患 / 催奇性 / CRBN / サリドマイド / 核内受容体 / 蛋白質分解 / Notch / ヘリカルペプチド / Hisタグ / タンパク質 / BCR-ABL / アンドロゲン受容体 / nuclear localization signal / Wnt signal / proteasome / ubiquitin / HIF / Wnt / Wntシグナル / apoptosis / snake venom / L-amino acid oxidase / 蛇毒 / アミノ酸オキシダーゼ / 細胞分裂 / UBCドメイン / 細胞周期 / サイクリンA / ケミカルバイオロジー / HECTドメイン / Pradar-Willi症候群 / HERC2 / 遺伝子増幅 / セリンプロテアーゼ / HtrA2 / カスパーゼ / 細胞死 / 活性酸素 / ネフローシス / 脳腫瘍 / 耐性 / アクチン / c-Abl / JNK / 抗癌剤 / Mutant / Cell fusion / ICE / 接着タンパク / 血液脳関門 / 血管内皮細胞 / P糖タンパク … More
Except Principal Investigator
耐性遺伝子 / 耐性タンパク / 抗癌剤耐性 / アポトーシス / ユビキチン / シグナル伝達 / モノクローナル抗体 / 多剤耐性 / 癌化学療法 / カルシウム拮抗薬 / モノクロ-ナル抗体 / 抗癌剤 / 転移 / 癌転移 / 耐性克服 / 分子標的 / P-糖タンパク / メタロチオネイン / 化学塞栓療法 / 薬物送達システム / 腫瘍・宿主条件 / アドリアマイシン / ビンクリスチン / ステープルペプチド / タンパク質化学合成 / 標的タンパク質分解誘導剤 / タンパク質分解 / 翻訳後修飾 / ケミカルバイオロジー / IAP / 細胞死 / がん / プロテアソーム / SNIPER / TACC3 / 接着 / 転写因子 / がん転移 / マクロライド / チロシンキナーゼ阻害剤 / 細胞周期 / がん化シグナル / Ets-1 / CDKインヒビター / cyclin D1 / がん抑制遺伝子 / がん遺伝子 / p21^<waf1> / RB / 血管新生 / 細胞接着 / Ablチロシンキナーゼ / Srcチロシンキナーゼ / p7056キナーゼ / MAPキナーゼ / Srcがん遺伝子 / Rasがん遺伝子 / U0126 / スクリーニング / 足場非依存性増殖 / ポンプ / イオン / 膜輸送体 / 抗がん剤耐性 / トランスポータ / 心臓 / 脳 / 糖尿病 / 電気生理学 / 分子生物学 / トランスポーター / チャネル / ATP / E-box認識転写制御因子 / UAGコドン / サプレッサーグルタミンtRNA / ナンセンスサプレッション / 翻訳反応 / 癌移転 / アポトーシス抑制因子 / アポトーシス耐性変異株 / 温度感受性変異株 / Fasリガンドシステム / Fas / s-myc遺伝子 / 生体防御 / 抗癌剤感受性 / 腫瘍ワクチン / 遺伝子治療 / ターゲティング / ドラッグデリバリーシステム / resorcinin / 抗がん物質 / ヒストン脱アセチル化阻害剤 / trapoxin / malolactomycin / ustiloxin / quinolidomicin / カルシウム拮抗剤 / ファーマコキネティクス / トポイソメラ-ゼ / P‐糖タンパク / ファ-マコキネティクス / Pー糖タンパク Less
  • Research Projects

    (38 results)
  • Research Products

    (326 results)
  • Co-Researchers

    (68 People)
  •  がん細胞で特異的に標的タンパク質を分解するLivin-SNIPERの開発Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      The University of Tokyo
  •  IAPアンタゴニスト-IAPペアのBump and Hole改変による新しいタンパク質分解系Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      The University of Tokyo
  •  STAT3を分解するPROTAC/SNIPERの分子設計、合成と活性評価Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      The University of Tokyo
  •  Deubiquitinase that inhibits degradation of oncogenic fusion proteins and its implication to cancer therapyPrincipal Investigator

    • Principal Investigator
      Naito Mikihiko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      The University of Tokyo
  •  New frontier for ubiquitin biology driven by chemo-technologies

    • Principal Investigator
      SAEKI Yasushi
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Chemical protein knockdown technology and cell regulationPrincipal Investigator

    • Principal Investigator
      Naito Mikihiko
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      The University of Tokyo
      National Institute of Health Sciences
  •  Manipulation of cellular function by forced ubiquitylationPrincipal Investigator

    • Principal Investigator
      NAITO MIKIHIKO
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Design of peptide ligands based on protein-protein interaction and their application to protein knockdown technologyPrincipal Investigator

    • Principal Investigator
      Naito Mikihiko
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Development of novel small molecules degrading microtubule-associated proteins

    • Principal Investigator
      Ohoka Nobumichi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  ケミカルバイオロジーを利用した人工的ユビキチン修飾システムの開発Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Health Sciences
  •  Mitosis regulation by ApollonPrincipal Investigator

    • Principal Investigator
      Naito Mikihiko
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Development of protein knockdown technology to degrade pathogenic proteinsPrincipal Investigator

    • Principal Investigator
      NAITO Mikihiko
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  細胞死阻害タンパク質の機能解析とがん治療への応用Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Health Sciences
      The University of Tokyo
  •  Apollonによる細胞周期制御因子のユビキチン化と細胞分裂期の制御Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Health Sciences
      The University of Tokyo
  •  細胞死阻害タンパク質の機能解析とがん治療への応用Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  巨大タンパク質HERC2の機能解析Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  細胞死阻害タンパク質の機能解析とがん治療への応用Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Regulation of the ubiquitin-proteasome system by cellular FLIPPrincipal Investigator

    • Principal Investigator
      NAITO Mikihiko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Caspase非依存性細胞死の誘導剤探索とその分子機構Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  FLIPによるアポトーシス制御機構の解析Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  細胞がん化のシグナル伝達の解析と特異的阻害剤の探索

    • Principal Investigator
      上原 至雅
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      National Institute of Infectious Diseases
  •  細胞死の分子機構とがん化学療法への応用Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  Molecular function and biosynthesis of apoxin I, an apoptosis inducing factor derived from snake venom.Principal Investigator

    • Principal Investigator
      NAITO Mikihiko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Institute of Molecular and Cellular Biosciences, The University of Tokyo
  •  ATP駆動型トランスポータとチャネルの構造・機能協関

    • Principal Investigator
      植田 和光
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  アポトーシス抵抗性変異細胞株の分離と細胞死の情報伝達機構の解析Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  がん細胞におけるアポトーシスの誘因と機構並びにその制御に関する研究

    • Principal Investigator
      口野 嘉幸
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  がん細胞の薬剤感受性と抵抗性の分子機構とその制御

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1994 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  細胞間相互作用を介してアポトーシスを制御する接着タンパクの解析Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  がん細胞におけるアポトーシスの誘因と機構並びにその制御に関する研究

    • Principal Investigator
      口野 嘉幸
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  難治性癌の薬剤抵抗性の分子機構とその克服

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  新規構造を有する天然物由来抗癌物質に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計

    • Principal Investigator
      橋田 充
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University
  •  P糖タンパクの発現を制御する組織因子の研究Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計

    • Principal Investigator
      橋田 充
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University
  •  腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計

    • Principal Investigator
      橋田 充
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University
  •  難治性癌の薬剤抵抗性の分子機構とその克服

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  難治性癌の薬剤抵抗性の分子機構とその克服

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  制がん剤耐性機構とその克服

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 2008 2007 2005 Other

All Journal Article Presentation Book Patent

  • [Book] 次世代医薬とバイオ医療、第9章新しい創薬手法ー標的タンパク質を分解するPROTAC2022

    • Author(s)
      内藤幹彦(長野哲雄、川西徹 編)
    • Total Pages
      272
    • Publisher
      東京化学同人
    • ISBN
      9784807920181
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Book] 次世代医薬とバイオ医療 第9章新しい創薬手法ー標的タンパク質を分解するPROTAC2022

    • Author(s)
      内藤幹彦(長野哲雄、川西徹 編)
    • Total Pages
      272
    • Publisher
      東京化学同人
    • ISBN
      9784807920181
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Book] 実験医学2020年9月号2020

    • Author(s)
      内藤 幹彦
    • Total Pages
      147
    • Publisher
      羊土社
    • ISBN
      9784758125352
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Book] 実験医学2020年9月号2020

    • Author(s)
      内藤 幹彦
    • Total Pages
      147
    • Publisher
      羊土社
    • ISBN
      9784758125352
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Book] "Chapter 16, Protein degradation inducers SNIPERs and PROTACs against oncogenic proteins, In Pharmaceutical Biocatalysis Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases"2019

    • Author(s)
      Shibata N, Ohoka N, Hattori T, Naito M.
    • Total Pages
      20
    • Publisher
      Jenny Stanford Publishing
    • ISBN
      9789814800617
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Journal Article] Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins.2024

    • Author(s)
      Yokoo H, Tsuji G, Inoue T, Naito M, Demizu Y, Ohoka N.
    • Journal Title

      Bioorg Chem.

      Volume: 145 Pages: 107204-107204

    • DOI

      10.1016/j.bioorg.2024.107204

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22K15257, KAKENHI-PLANNED-23H04926, KAKENHI-PROJECT-21H02777
  • [Journal Article] Current Status of Oligonucleotide-Based Protein Degraders2023

    • Author(s)
      Po-Chang Shih, Miyako Naganuma, Yosuke Demizu, Mikihiko Naito
    • Journal Title

      Pharmaceutics

      Volume: 15 Issue: 3 Pages: 765-765

    • DOI

      10.3390/pharmaceutics15030765

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22KJ2565, KAKENHI-PROJECT-22KF0090, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] Synthesis of SNIPERs against BCR-ABL with kinase inhibitors and a method to evaluate their growth inhibitory activity derived from BCR-ABL degradation2023

    • Author(s)
      Cho Nobuo、Naito Mikihiko
    • Journal Title

      Methods Enzymol

      Volume: 681 Pages: 41-60

    • DOI

      10.1016/bs.mie.2022.09.001

    • ISBN
      9780323992008
    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] Development of decoy oligonucleotide-warheaded chimeric molecules targeting STAT32023

    • Author(s)
      Shih Po-Chang、Naganuma Miyako、Tsuji Genichiro、Demizu Yosuke、Naito Mikihiko
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 95 Pages: 117507-117507

    • DOI

      10.1016/j.bmc.2023.117507

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22KF0090, KAKENHI-PROJECT-22KJ2565, KAKENHI-PLANNED-23H04926, KAKENHI-PROJECT-21H02777
  • [Journal Article] Investigating the cell permeability of proteolysis-targeting chimeras (PROTACs)2023

    • Author(s)
      Yokoo Hidetomo、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      Expert Opinion on Drug Discovery

      Volume: 18 Issue: 4 Pages: 357-361

    • DOI

      10.1080/17460441.2023.2187047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K15257, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] Development of versatile solid-phase methods for syntheses of PROTACs with diverse E3 ligands2023

    • Author(s)
      Xu Hanqiao、Kurohara Takashi、Ohoka Nobumichi、Tsuji Genichiro、Inoue Takao、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      Bioorganic &amp; Medicinal Chemistry

      Volume: 86 Pages: 117293-117293

    • DOI

      10.1016/j.bmc.2023.117293

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23H04926, KAKENHI-PROJECT-21H02777
  • [Journal Article] Development of DNA Aptamer-Based PROTACs That Degrade the Estrogen Receptor.2023

    • Author(s)
      Tsujimura H, Naganuma M, Ohoka N, Inoue T, Naito M, Tsuji G, Demizu Y.
    • Journal Title

      ACS Med Chem Lett.

      Volume: 14 Issue: 6 Pages: 827-832

    • DOI

      10.1021/acsmedchemlett.3c00126

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22KJ2565, KAKENHI-PLANNED-23H04926, KAKENHI-PROJECT-21H02777
  • [Journal Article] Inducing Protein Degradation to Overcome Resistance to Kinase Inhibitors2023

    • Author(s)
      Sato Waka、Naito Mikihiko
    • Journal Title

      Biochemistry

      Volume: 62 Issue: 3 Pages: 557-558

    • DOI

      10.1021/acs.biochem.2c00223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K20707, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] IAPの医薬品開発ーIAPアンタゴニストとSNIPER2022

    • Author(s)
      内藤 幹彦
    • Journal Title

      医学のあゆみ

      Volume: 283 Pages: 524-530

    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Journal Article] Development of a potent small-molecule degrader against oncogenic BRAFV600E protein that evades paradoxical MAPK activation.2022

    • Author(s)
      Ohoka N, Suzuki M, Uchida T, Tsukumo Y, Yoshida M, Inoue T, Ohki H, Naito M.
    • Journal Title

      Cancer Sci.

      Volume: 113 Issue: 8 Pages: 2828-2838

    • DOI

      10.1111/cas.15401

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-19K07724, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] Molecular Design, Synthesis, and Evaluation of SNIPER (ER) that Induces Targeted Protein Degradation of ERα2022

    • Author(s)
      Ohoka N, Yokoo H, Okuhira K, Demizu Y, Naito M.
    • Journal Title

      Methods Mol Biol.

      Volume: 2418 Pages: 363-382

    • DOI

      10.1007/978-1-0716-1920-9_20

    • ISBN
      9781071619193, 9781071619209
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-21K05320, KAKENHI-PLANNED-18H05502
  • [Journal Article] Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles2022

    • Author(s)
      Xu Hanqiao、Kurohara Takashi、Takano Reina、Yokoo Hidetomo、Shibata Norihito、Ohoka Nobumichi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      ChemistryOpen

      Volume: 11 Issue: 7

    • DOI

      10.1002/open.202200131

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06075, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein degrader2022

    • Author(s)
      Nakano Naoko、Fukuda Kazuo、Tashiro Etsu、Ishikawa Haruka、Nagano Waka、Kawamoto Rie、Mori Alice、Watanabe Misao、Yamazaki Ryu、Nakane Takahisa、Naito Mikihiko、Okamoto Iwao、Itoh Susumu
    • Journal Title

      The Journal of Biochemistry

      Volume: - Issue: 6 Pages: 631-640

    • DOI

      10.1093/jb/mvac021

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06975, KAKENHI-PROJECT-20K05732, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H03456
  • [Journal Article] Structure?activity relationship study of PROTACs against hematopoietic prostaglandin D<sub>2</sub> synthase2022

    • Author(s)
      Murakami Yuki、Osawa Hinata、Kurohara Takashi、Yanase Yuta、Ito Takahito、Yokoo Hidetomo、Shibata Norihito、Naito Mikihiko、Aritake Kosuke、Demizu Yosuke
    • Journal Title

      RSC Medicinal Chemistry

      Volume: 13 Issue: 12 Pages: 1495-1503

    • DOI

      10.1039/d2md00284a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06075, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] Targeted protein degradation and drug discovery2022

    • Author(s)
      Naito Mikihiko
    • Journal Title

      The Journal of Biochemistry

      Volume: 172 Issue: 2 Pages: 61-69

    • DOI

      10.1093/jb/mvac041

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] 標的タンパク質分解誘導薬の開発展望2022

    • Author(s)
      内藤 幹彦
    • Journal Title

      腫瘍内科

      Volume: 29 Pages: 626-631

    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Journal Article] Development of a degrader against oncogenic fusion protein FGFR3-TACC32022

    • Author(s)
      Shibata Norihito、Cho Nobuo、Koyama Hiroo、Naito Mikihiko
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 60 Pages: 128584-128584

    • DOI

      10.1016/j.bmcl.2022.128584

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07311, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06075, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502
  • [Journal Article] Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein2022

    • Author(s)
      Ohoka Nobumichi、Suzuki Masanori、Uchida Takuya、Tsuji Genichiro、Tsukumo Yoshinori、Yoshida Masayuki、Inoue Takao、Demizu Yosuke、Ohki Hitoshi、Naito Mikihiko
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 13 Issue: 12 Pages: 1885-1891

    • DOI

      10.1021/acsmedchemlett.2c00402

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-19K07724, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] cIAP1-based degraders induce degradation via branched ubiquitin architectures2022

    • Author(s)
      Akizuki Yoshino、Morita Mai、Mori Yuki、Kaiho-Soma Ai、Dixit Shivani、Endo Akinori、Shimogawa Marie、Hayashi Gosuke、Naito Mikihiko、Okamoto Akimitsu、Tanaka Keiji、Saeki Yasushi、Ohtake Fumiaki
    • Journal Title

      Nature Chemical Biology

      Volume: 19 Issue: 3 Pages: 311-322

    • DOI

      10.1038/s41589-022-01178-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22H00419, KAKENHI-PROJECT-20K06568, KAKENHI-PROJECT-21K19040, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-18H05504, KAKENHI-PROJECT-21H02777
  • [Journal Article] Targeted protein degradation and drug discovery2022

    • Author(s)
      内藤 幹彦
    • Journal Title

      生化学

      Volume: 94 Issue: 2 Pages: 258-270

    • DOI

      10.14952/SEIKAGAKU.2022.940258

    • ISSN
      0037-1017
    • Year and Date
      2022-04-25
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling2022

    • Author(s)
      Yu Shuiliang、Wang Lei、Che Danian、Zhang Mei、Li Ming、Naito Mikihiko、Xin Wei、Zhou Lan
    • Journal Title

      Journal of Experimental & Clinical Cancer Research

      Volume: 41 Issue: 1 Pages: 88-88

    • DOI

      10.1186/s13046-022-02261-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02777, KAKENHI-PLANNED-18H05502
  • [Journal Article] Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation2021

    • Author(s)
      Yokoo Hidetomo、Ohoka Nobumichi、Takyo Mami、Ito Takahito、Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 16 Pages: 8772-8772

    • DOI

      10.3390/ijms22168772

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-20K22711
  • [Journal Article] Development of Agonist-Based PROTACs Targeting Liver X Receptor2021

    • Author(s)
      Xu Hanqiao、Ohoka Nobumichi、Yokoo Hidetomo、Nemoto Kanako、Ohtsuki Takashi、Matsufuji Hiroshi、Naito Mikihiko、Inoue Takao、Tsuji Genichiro、Demizu Yosuke
    • Journal Title

      Frontiers in Chemistry

      Volume: 9 Pages: 674967-674967

    • DOI

      10.3389/fchem.2021.674967

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320
  • [Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021

    • Author(s)
      Yokoo Hidetomo、Shibata Norihito、Naganuma Miyako、Murakami Yuki、Fujii Kiyonaga、Ito Takahito、Aritake Kosuke、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 12 Issue: 2 Pages: 236-241

    • DOI

      10.1021/acsmedchemlett.0c00605

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07311, KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-17K08385, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320
  • [Journal Article] Intermolecular interaction-based ubiquitin-proteasome system-targeting drug discovery2021

    • Author(s)
      Naito Mikihiko、Komatsu Hirotsugu
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 156 Issue: 1 Pages: 9-12

    • DOI

      10.1254/fpj.20070

    • NAID

      130007965017

    • ISSN
      0015-5691, 1347-8397
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands2021

    • Author(s)
      Naganuma M, Ohoka N, Tsuji G, Tsujimura H, Matsuno K, Inoue T, Naito M, Demizu Y.
    • Journal Title

      ACS Med Chem Lett.

      Volume: 13 Issue: 1 Pages: 134-139

    • DOI

      10.1021/acsmedchemlett.1c00629

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22KJ2565, KAKENHI-PROJECT-21K05320, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
  • [Journal Article] Protocols for Synthesis of and the Methods to Evaluate the Anticancer Effects2021

    • Author(s)
      Tsukumo Yoshinori、Tsuji Genichiro、Yokoo Hidetomo、Shibata Norihito、Ohoka Nobumichi、Demizu Yosuke、Naito Mikihiko
    • Journal Title

      Methods Mol. Biol.

      Volume: 2365 Pages: 331-347

    • DOI

      10.1007/978-1-0716-1665-9_18

    • ISBN
      9781071616642, 9781071616659
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-19K07724, KAKENHI-PROJECT-21K05320
  • [Journal Article] Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design2021

    • Author(s)
      Yokoo Hidetomo、Shibata Norihito、Endo Akinori、Ito Takahito、Yanase Yuta、Murakami Yuki、Fujii Kiyonaga、Hamamura Kengo、Saeki Yasushi、Naito Mikihiko、Aritake Kosuke、Demizu Yosuke
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 64 Issue: 21 Pages: 15868-15882

    • DOI

      10.1021/acs.jmedchem.1c01206

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-20K06568, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K11613, KAKENHI-PROJECT-20K22711
  • [Journal Article] ハイブリッド化合物(PROTAC、SNIPER)2021

    • Author(s)
      内藤幹彦
    • Journal Title

      細胞

      Volume: 53 Pages: 136-139

    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Journal Article] TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains2021

    • Author(s)
      Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
    • Journal Title

      Molecular Cell

      Volume: 81 Issue: 7 Pages: 1411-1424.e7

    • DOI

      10.1016/j.molcel.2021.01.023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-17H01882, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22726, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-21H03604, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-20K21408
  • [Journal Article] Gluing Proteins for Targeted Degradation2021

    • Author(s)
      Naito Mikihiko、Murata Shigeo
    • Journal Title

      Cancer Cell

      Volume: 39 Issue: 1 Pages: 19-21

    • DOI

      10.1016/j.ccell.2020.12.020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-18H05502, KAKENHI-ORGANIZER-18H05497
  • [Journal Article] Critical role of mitochondrial ubiquitination and the OPTN?ATG9A axis in mitophagy2020

    • Author(s)
      Yamano Koji、Kikuchi Reika、Kojima Waka、Hayashida Ryota、Koyano Fumika、Kawawaki Junko、Shoda Takuji、Demizu Yosuke、Naito Mikihiko、Tanaka Keiji、Matsuda Noriyuki
    • Journal Title

      Journal of Cell Biology

      Volume: 219 Issue: 9 Pages: 1-23

    • DOI

      10.1083/jcb.201912144

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05500, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06237, KAKENHI-ORGANIZER-18H05497
  • [Journal Article] キメラ化合物PROTAC/SNIPERの作用機序と新たな開発の動向2020

    • Author(s)
      大岡伸通、内藤幹彦
    • Journal Title

      実験医学

      Volume: 38 Pages: 2321-2325

    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Journal Article] 脱ユビキチン化酵素阻害によるプロテインノックダウン2020

    • Author(s)
      柴田識人、内藤幹彦
    • Journal Title

      実験医学

      Volume: 38 Pages: 2337-2341

    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Journal Article] Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors2020

    • Author(s)
      Yokoo Hidetomo、Ohoka Nobumichi、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 28 Issue: 15 Pages: 115595-115595

    • DOI

      10.1016/j.bmc.2020.115595

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502
  • [Journal Article] Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs2020

    • Author(s)
      Ishikawa Minoru、Tomoshige Shusuke、Demizu Yosuke、Naito Mikihiko
    • Journal Title

      Pharmaceuticals

      Volume: 13 Issue: 4 Pages: 74-74

    • DOI

      10.3390/ph13040074

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551, KAKENHI-ORGANIZER-18H05497
  • [Journal Article] Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety.2020

    • Author(s)
      Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
    • Journal Title

      Pharmaceuticals (Basel).

      Volume: 13 Issue: 3 Pages: 34-34

    • DOI

      10.3390/ph13030034

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05502, KAKENHI-ORGANIZER-18H05497
  • [Journal Article] プロテインノックダウン技術の沿革と今後の展開2020

    • Author(s)
      内藤幹彦
    • Journal Title

      実験医学

      Volume: 38 Pages: 2300-2304

    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Journal Article] Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells2020

    • Author(s)
      Shibata Norihito、Ohoka Nobumichi、Tsuji Genichiro、Demizu Yosuke、Miyawaza Keiji、Ui-Tei Kumiko、Akiyama Tetsu、Naito Mikihiko
    • Journal Title

      Oncogene

      Volume: - Issue: 19 Pages: 3867-3878

    • DOI

      10.1038/s41388-020-1253-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502, KAKENHI-ORGANIZER-18H05497
  • [Journal Article] 開発経緯と最新の動向2020

    • Author(s)
      大岡 伸通、内藤 幹彦
    • Journal Title

      Farumashia

      Volume: 56 Issue: 1 Pages: 41-45

    • DOI

      10.14894/faruawpsj.56.1_41

    • NAID

      130007779032

    • ISSN
      0014-8601, 2189-7026
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Journal Article] SNIPERs - Hijacking IAP activity to induce protein degradation.2019

    • Author(s)
      Naito M, Ohoka N, Shibata N.
    • Journal Title

      Drug Discovery Today: Technology

      Volume: 印刷中 Pages: 481-488

    • DOI

      10.1016/j.ddtec.2018.12.002

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502
  • [Journal Article] Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs.2019

    • Author(s)
      Naito M, Ohoka N, Shibata N, Tsukumo Y.
    • Journal Title

      Front Chem.

      Volume: 7 Pages: 849-849

    • DOI

      10.3389/fchem.2019.00849

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07724, KAKENHI-PLANNED-18H05502
  • [Journal Article] Development of small molecule chimeric degraders that bring target proteins and the aryl hydrocarbon receptor (AhR) E3 ligase into close proximity2019

    • Author(s)
      N. Ohoka, G. Tsuji, T. Shoda, T. Fujisato, M. Kurihara, Y. Demizu, M. Naito*
    • Journal Title

      ACS Chem. Biol.

      Volume: 14 Issue: 12 Pages: 2822-2832

    • DOI

      10.1021/acschembio.9b00704

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16K08340
  • [Journal Article] Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein2019

    • Author(s)
      Shibata Norihito、Ohoka Nobumichi、Hattori Takayuki、Naito Mikihiko
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 67 Issue: 3 Pages: 165-172

    • DOI

      10.1248/cpb.c18-00703

    • NAID

      130007606378

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2019-03-01
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
  • [Journal Article] Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)2019

    • Author(s)
      Ohoka Nobumichi、Ujikawa Osamu、Shimokawa Kenichiro、Sameshima Tomoya、Shibata Norihito、Hattori Takayuki、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 67 Issue: 3 Pages: 203-209

    • DOI

      10.1248/cpb.c18-00567

    • NAID

      130007607114

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2019-03-01
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
  • [Journal Article] Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues2019

    • Author(s)
      Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y
    • Journal Title

      Med Chem Comm

      Volume: 印刷中 Issue: 6 Pages: 896-900

    • DOI

      10.1039/c9md00166b

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17K08385
  • [Journal Article] Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating peptide foldamers for efficient siRNA delivery2019

    • Author(s)
      T. Misawa,* N. Ohoka,* M. Oba, H. Yamashita, M. Tanaka, M. Naito, Y. Demizu*
    • Journal Title

      Chem. Commun.

      Volume: 55 Issue: 54 Pages: 7792-7795

    • DOI

      10.1039/c9cc02203a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502
  • [Journal Article] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase2018

    • Author(s)
      Shibata Norihito、Shimokawa Kenichiro、Nagai Katsunori、Ohoka Nobumichi、Hattori Takayuki、Miyamoto Naoki、Ujikawa Osamu、Sameshima Tomoya、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 13549-13549

    • DOI

      10.1038/s41598-018-31913-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
  • [Journal Article] Development of a small hybrid molecule that mediates degradation of His-tag fused proteins2018

    • Author(s)
      K. Okitsu, T. Hattori, T. Misawa, T. Shoda, M. Kurihara, M. Naito, Y. Demizu
    • Journal Title

      J Med Chem.

      Volume: 61 Issue: 2 Pages: 576-582

    • DOI

      10.1021/acs.jmedchem.7b00413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-17K08385
  • [Journal Article] Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation2018

    • Author(s)
      Ohoka Nobumichi、Morita Yoko、Nagai Katsunori、Shimokawa Kenichiro、Ujikawa Osamu、Fujimori Ikuo、Ito Masahiro、Hayase Youji、Okuhira Keiichiro、Shibata Norihito、Hattori Takayuki、Sameshima Tomoya、Sano Osamu、Koyama Ryokichi、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Journal of Biological Chemistry

      Volume: 293 Issue: 18 Pages: 6776-6790

    • DOI

      10.1074/jbc.ra117.001091

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
  • [Journal Article] Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands2017

    • Author(s)
      Shibata Norihito、Nagai Katsunori、Morita Yoko、Ujikawa Osamu、Ohoka Nobumichi、Hattori Takayuki、Koyama Ryokichi、Sano Osamu、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 61 Issue: 2 Pages: 543-575

    • DOI

      10.1021/acs.jmedchem.7b00168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.2017

    • Author(s)
      Ohoka, N., Nagai, K., Shibata, N., Hattori, T., Nara, H., Cho, N. & Naito, M.
    • Journal Title

      Cancer Sci

      Volume: 108 Issue: 5 Pages: 1032-1041

    • DOI

      10.1111/cas.13198

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121
  • [Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consist of His-tag ligand, ubiquitin ligase ligand and cell penetrating peptide2017

    • Author(s)
      T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 18 Pages: 4478-4481

    • DOI

      10.1016/j.bmcl.2017.08.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
  • [Journal Article] Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters.2017

    • Author(s)
      Yamashita H, Misawa T, Oba M, Tanaka M, Naito M, Kurihara M, Demizu Y.
    • Journal Title

      Bioorg Med Chem.

      Volume: 25(6) Issue: 6 Pages: 1846-1851

    • DOI

      10.1016/j.bmc.2017.01.044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26290055, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).2017

    • Author(s)
      Ohoka, N., Okuhira, K., Ito, M., Nagai, K., Shibata, N., Hattori, T., Ujikawa, O., Shimokawa, K., Sano, O., Koyama, R., Fujita, H., Teratani, M., Matsumoto, H., Imaeda, Y., Nara, H., Cho, N. & Naito, M.
    • Journal Title

      J Biol Chem

      Volume: 292 Issue: 11 Pages: 4556-4570

    • DOI

      10.1074/jbc.m116.768853

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K08236
  • [Journal Article] Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation2017

    • Author(s)
      Shimokawa Kenichiro、Shibata Norihito、Sameshima Tomoya、Miyamoto Naoki、Ujikawa Osamu、Nara Hiroshi、Ohoka Nobumichi、Hattori Takayuki、Cho Nobuo、Naito Mikihiko
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 8 Issue: 10 Pages: 1042-1047

    • DOI

      10.1021/acsmedchemlett.7b00247

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] Development of a peptide-based inducer of protein degradation targeting NOTCH12017

    • Author(s)
      Ohoka N, Misawa T, Kurihara M, Demizu Y, Naito M.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 27 Issue: 22 Pages: 4985-4988

    • DOI

      10.1016/j.bmcl.2017.10.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
  • [Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.2017

    • Author(s)
      Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
    • Journal Title

      Mol pharmacol

      Volume: 91 Issue: 3 Pages: 159-166

    • DOI

      10.1124/mol.116.105569

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979
  • [Journal Article] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2017

    • Author(s)
      Shibata Norihito、Miyamoto Naoki、Nagai Katsunori、Shimokawa Kenichiro、Sameshima Tomoya、Ohoka Nobumichi、Hattori Takayuki、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 8 Pages: 1657-1666

    • DOI

      10.1111/cas.13284

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.2016

    • Author(s)
      Ohoka, N., Shibata, N., Hattori, T. & Naito, M.
    • Journal Title

      Curr Cancer Drug Targets

      Volume: 16 Pages: 136-146

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Journal Article] Induction of proteasomal degradation of ERα and subsequent cell death in breast cancer cells2016

    • Author(s)
      K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
    • Journal Title

      Methods Mol. Biol.

      Volume: 1366 Pages: 549-560

    • DOI

      10.1007/978-1-4939-3127-9_42

    • ISBN
      9781493931262, 9781493931279
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-16H05090
  • [Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.2016

    • Author(s)
      Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 26 Issue: 20 Pages: 4865-4869

    • DOI

      10.1016/j.bmcl.2016.09.041

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916
  • [Journal Article] Development of a peptide-based inducer of nuclear receptors degradation.2016

    • Author(s)
      Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 26 Issue: 11 Pages: 2655-2658

    • DOI

      10.1016/j.bmcl.2016.04.013

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
  • [Journal Article] Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.2016

    • Author(s)
      Ohoka N, Shibata N, Hattori T, Naito M.
    • Journal Title

      Current Cancer Drug Targets

      Volume: 16 Issue: 2 Pages: 136-146

    • DOI

      10.2174/1568009616666151112122502

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050
  • [Journal Article] Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.2015

    • Author(s)
      Shibata N, Ohoka N, Sugaki Y, Onodera C, Inoue M, Sakuraba Y, Takakura D, Hashii N, Kawasaki N, Gondo Y, Naito M
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 47 Pages: 28428-28437

    • DOI

      10.1074/jbc.m115.670901

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25460084
  • [Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton2015

    • Author(s)
      Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 22 Pages: 5362-5366

    • DOI

      10.1016/j.bmcl.2015.09.030

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26860049
  • [Journal Article] Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.2014

    • Author(s)
      Shoda, T., Okuhira, K., Kato, M., Demizu, Y., Inoue, H., Naito, M., and Kurihara, M.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 24 Issue: 1 Pages: 87-89

    • DOI

      10.1016/j.bmcl.2013.11.078

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
  • [Journal Article] Apollon/Bruce is upregulated by Humanin.2014

    • Author(s)
      4.Hashimoto, Y., Takeshita, Y., Naito, M., Uchino, H. and Matsuoka, M
    • Journal Title

      Mol Cell Biochem.

      Volume: 397 Issue: 1-2 Pages: 147-55

    • DOI

      10.1007/s11010-014-2182-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25460084, KAKENHI-PROJECT-25460343
  • [Journal Article] Apollon protein promotes early mitotic Cyclin A degradation independent of the spindle assembly checkpoint.2014

    • Author(s)
      Kikuchi, R., Ohata, H., Ohoka, N., Kawabata, A., Naito, M.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 289 Issue: 6 Pages: 3457-3467

    • DOI

      10.1074/jbc.m113.514430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790117, KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25460084
  • [Journal Article] Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin proteasome pathway.2014

    • Author(s)
      1.Ohoka, N., Nagai, K., Hattori, T., Okuhira, K., Shibata, N., Cho, N. and Naito, M
    • Journal Title

      Cell Death Dis.

      Volume: 5 Issue: 11 Pages: e1513-e1513

    • DOI

      10.1038/cddis.2014.471

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26860049
  • [Journal Article] Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.2014

    • Author(s)
      2.Nagakubo, T., Demizu, Y., Kanda, Y., Misawa, T., Shoda, T., Okuhira, K., Sekino., Y., Naito, M. and Kurihara, M
    • Journal Title

      Bioconjug Chem.

      Volume: 25 Issue: 11 Pages: 1921-24

    • DOI

      10.1021/bc500480e

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
  • [Journal Article] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.2013

    • Author(s)
      Okuhira, K., Demizu, Y., Hattori, T., Ohoka, N., Shibata, N., Nishimaki-Mogami, T., Okuda, H., Kurihara, M., Natiro, M.
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 11 Pages: 1492-1498

    • DOI

      10.1111/cas.12272

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790117, KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084
  • [Journal Article] Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist2012

    • Author(s)
      Itoh, Y., Ishikawa, M., Kitaguchi, R., Okuhira, K., Naito, M. & Hashimoto, Y.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 22 Pages: 4453-4457

    • Data Source
      KAKENHI-PROJECT-23659048
  • [Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012

    • Author(s)
      Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito, M. Kurihara
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 22 Issue: 4 Pages: 1793-1796

    • DOI

      10.1016/j.bmcl.2011.11.086

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-23659048
  • [Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012

    • Author(s)
      Demizu, Y., Okuhira, K., Motoi, H., Ohno, A., Shoda, T., Fukuhara, K., Okuda, H., Naito, M. & Kurihara, M.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 22 Pages: 1793-1796

    • Data Source
      KAKENHI-PROJECT-23659048
  • [Journal Article] Development of target protein-selective degradation inducer for protein knockdown2011

    • Author(s)
      Itoh, Y., Ishikawa, M., Kitaguchi, R., Sato, S., Naito, M. & Hashimoto, Y.
    • Journal Title

      Bioorg Med Chem

      Volume: 19 Pages: 3229-3241

    • Data Source
      KAKENHI-PROJECT-23659048
  • [Journal Article] Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein2011

    • Author(s)
      Okuhira, K., Ohoka, N., Sai, K., Nishimaki-Mogami, T., Itoh, Y., Ishikawa, M., Hashimoto, Y. & Naito, M.
    • Journal Title

      FEBS Lett

      Volume: 585 Pages: 1147-1152

    • Data Source
      KAKENHI-PROJECT-23659048
  • [Journal Article] Development oftarget protein-selective degradation inducerfor protein knockdown2011

    • Author(s)
      Y. Itoh, M. Ishikawa, R. Kitaguchi, S. Sato, M. Naito, Y. Hashimoto
    • Journal Title

      Bioorg. Med. Chem

      Volume: 19 Issue: 10 Pages: 3229-3241

    • DOI

      10.1016/j.bmc.2011.03.057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23659048
  • [Journal Article] Design, synthesis and biological evaluation of nuclear receptor-degradation inducers.2011

    • Author(s)
      Itoh, Y., Kitaguchi, R., Ishikawa, M., Naito, M. & Hashimoto, Y.
    • Journal Title

      Bioorg Med Chem

      Volume: 19 Pages: 6768-6778

    • Data Source
      KAKENHI-PROJECT-23659048
  • [Journal Article] Specific degradation of CRABP-II via cIAP1-mediatd ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein2011

    • Author(s)
      K. Okuhira, N. Ohoka, K. Sai, T. Nishimaki-Mogami, Y. Itoh, M. Ishikawa, Y. Hashimoto, M. Naito
    • Journal Title

      FEBS Lett.

      Volume: 585 Issue: 8 Pages: 1147-1152

    • DOI

      10.1016/j.febslet.2011.03.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048
  • [Journal Article] Impairment of the ubiquitin-proteasome system by cellular FLIP.2007

    • Author(s)
      Ishioka, T., Katayama, R., Kikuchi, R., Nishimoto, M., Takada, S., Takada, R., Matsuzawa, S.I., Reed, J.C., Tsuruo, T., Naito, M.
    • Journal Title

      Genes Cells 12

      Pages: 735-744

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390017
  • [Journal Article] Functional characterization of adenosine transport across the BBB in mice.2005

    • Author(s)
      Murakami, H., Ohkura, A., Takanaga, H., Matsuo, H., Koyabu, N., Naito, M., Tsuruo, T., Ohtani, H., Sawada, Y.
    • Journal Title

      Int J Pharm 290

      Pages: 37-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390017
  • [Journal Article] Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production.2005

    • Author(s)
      Dohgu, S., Takata, F., Yamauchi, A., Nakagawa, S., Egawa, T., Naito, M., Tsuruo, T., Sawada, Y., Niwa, M., Kataoka, Y.
    • Journal Title

      Brain Res 1038

      Pages: 208-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390017
  • [Journal Article] Cell differentiation inducers derived from thalidomide.2005

    • Author(s)
      Noguchi, T., Miyachi, H., Katayama, R., Naito, M., Hashimoto, Y.
    • Journal Title

      Bioorg Med Chem Lett 15

      Pages: 3212-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390017
  • [Journal Article] HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells.2005

    • Author(s)
      Sekine, K., Hao, Y., Suzuki, Y., Takahashi, R., Tsuruo, T., Naito, M.
    • Journal Title

      Biochem Biophys Res Commun 330

      Pages: 279-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390017
  • [Patent] 新規化合物及び医薬組成物2021

    • Inventor(s)
      出水庸介,柴田識人,内藤幹彦,有竹浩介,横尾英知
    • Industrial Property Rights Holder
      出水庸介,柴田識人,内藤幹彦,有竹浩介,横尾英知
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-115706
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Patent] 新規化合物及び医薬組成物2021

    • Inventor(s)
      出水庸介,柴田識人,内藤幹彦,有竹浩介,横尾英知
    • Industrial Property Rights Holder
      出水庸介,柴田識人,内藤幹彦,有竹浩介,横尾英知
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-115706
    • Filing Date
      2021
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Patent] 新規化合物及び医薬組成物2021

    • Inventor(s)
      出水庸介,柴田識人,内藤幹彦,有竹浩介,横尾英知
    • Industrial Property Rights Holder
      出水庸介,柴田識人,内藤幹彦,有竹浩介,横尾英知
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-016808
    • Filing Date
      2021
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Patent] 複素環化合物2016

    • Inventor(s)
      内藤幹彦, 大岡伸通, 柴田識人, 奥平桂一郎, 他12名
    • Industrial Property Rights Holder
      内藤幹彦, 大岡伸通, 柴田識人, 奥平桂一郎, 他12名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-196803
    • Filing Date
      2016-10-04
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Patent] アポトーシス阻害タンパク質リガンド-エストロゲン受容体リガンドハイブリッド化合物並びにそれを利用したエストロゲン受容体分解誘導剤及び乳癌、子宮頚癌又は卵巣癌の予防及び治療剤2011

    • Inventor(s)
      内藤幹彦、奥平桂一郎、出水庸介、栗原正明
    • Industrial Property Rights Holder
      内藤幹彦、奥平桂一郎、出水庸介、栗原正明
    • Industrial Property Number
      2011-195081
    • Filing Date
      2011
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] PROTAC/SNIPERによるタンパク質分解と、 最近のキメラ化合物によるタンパク質の機能制御2024

    • Author(s)
      内藤幹彦
    • Organizer
      理化学研究所 DMP創薬セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] 標的タンパク質を分解する技術と創薬2023

    • Author(s)
      内藤幹彦
    • Organizer
      日本薬物動態学会第16回ショートコース
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] Inducing protein degradation for precision medicine against cancer2023

    • Author(s)
      Mikihiko Naito
    • Organizer
      2nd Targeted Protein Degradation Conference in Japan
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] タンパク質分解技術と創薬2023

    • Author(s)
      内藤幹彦
    • Organizer
      日本薬剤学会第38年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] タンパク質分解を誘導する化合物2023

    • Author(s)
      内藤幹彦
    • Organizer
      第34回万有仙台シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] H-PGDSを標的とするPROTACの構造活性相関研究2023

    • Author(s)
      黒原崇,大澤陽,柴田識人,有竹浩介,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第143回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Targeted protein degradation for anti-cancer drug development2023

    • Author(s)
      内藤幹彦
    • Organizer
      第50回日本毒性学会学術年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] CRBNリガンドに着目したH-PGDS分解誘導剤の構造活性相関研究2023

    • Author(s)
      大澤陽,黒原崇,柴田識人,有竹浩介,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第143回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 生体内安定性の向上を志向したデコイ核酸型PROTACの創製2023

    • Author(s)
      永沼美弥子,大岡伸通,辻厳一郎,内藤幹彦,井上貴雄,出水庸介
    • Organizer
      日本薬学会第143回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 標的リガンドにオリゴヌクレオチドを応用したPROTACの創製2022

    • Author(s)
      永沼美弥子,大岡伸通,辻厳一郎,松野研司,内藤幹彦,井上貴雄,出水庸介
    • Organizer
      第39回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Targeted protein degradation by chimeric molecules, PROTACs and SNIPERs2022

    • Author(s)
      Mikihiko Naito
    • Organizer
      KSBMB INTERNATIONAL CONFERENCE 2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] 新しい創薬モダリティーとしてのタンパク質分解技術2022

    • Author(s)
      内藤幹彦
    • Organizer
      第24回インターフェックス ジャパン
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] 新しい創薬モダリティーとしてのタンパク質分解技術2022

    • Author(s)
      内藤幹彦
    • Organizer
      第24回インターフェックス ジャパン
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Towards development of protein degraders for targeting signal transducer and activator of transcription 3 (STAT3)2022

    • Author(s)
      Shih Po-C, Naganuma M, Tsuji G, Demizu Y, Naito M.
    • Organizer
      Ubiquitin New Frontier from Neo-biology to Targeted Protein Degradation
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 造血器型プロスタグランジンD合成酵素選択的タンパク質分解誘導剤の開発2022

    • Author(s)
      柴田識人,横尾英知,遠藤彬則,伊藤貴仁,栁瀨雄太,村上優貴,藤井清永,佐伯泰,内藤幹彦,有竹浩介,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Technologies to induce targeted protein degradation and their application for drug development2022

    • Author(s)
      Mikihiko Naito
    • Organizer
      The 95th Annual Meeting of the Japanese Pharmaceutical Society
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Specific degrader of hematopoietic prostaglandin D synthase prevented the progression of dilated cardiomyopathy in Duchenne muscular dystrophy2022

    • Author(s)
      Maeyama, Y., Hosokawa, Y., Hamamura, K., Yokoo, H., Shibata, N., Naito, M., Demizu, Y., Aritake, K.
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Targeted protein degradation by chimeric molecules, PROTACs and SNIPERs2022

    • Author(s)
      Mikihiko Naito
    • Organizer
      KSBMB INTERNATIONAL CONFERENCE 2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 固相法によるPROTACの迅速合成2022

    • Author(s)
      許涵喬,黒原崇,柴田識人,大岡伸通,井上貴雄,内藤幹彦,出水庸介
    • Organizer
      第48回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase2022

    • Author(s)
      Osawa H, Kurohara T, Murakami Y, Shibata N, Naito M, Demizu Y.
    • Organizer
      Ubiquitin New Frontier from Neo-biology to Targeted Protein Degradation
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Towards development of protein degraders for targeting signal transducer and activator of transcription 3 (STAT3)2022

    • Author(s)
      Shih Po-C, Naganuma M, Tsuji G, Demizu Y, Naito M.
    • Organizer
      Ubiquitin New Frontier from Neo-biology to Targeted Protein Degradation
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22KF0090
  • [Presentation] デコイ核酸を利用したキメラ分子による標的タンパク質分解2022

    • Author(s)
      大岡伸通,内藤幹彦,出水庸介
    • Organizer
      第26回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] リンカー構造に着目したH-PGDS分解誘導剤の構造活性相関研究2022

    • Author(s)
      大澤陽,黒原崇,横尾英知,伊藤貴仁,栁瀨雄太,柴田識人,大槻崇,松藤寛,有竹浩介,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] タンパク質分解技術と創薬2022

    • Author(s)
      内藤幹彦
    • Organizer
      ゲノム創薬・創発フォーラム第10回シンポジウム
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] タンパク質分解技術と創薬2022

    • Author(s)
      内藤幹彦
    • Organizer
      ゲノム創薬・創発フォーラム 第10回シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase2022

    • Author(s)
      大澤陽,黒原崇,村上優貴,柴田識人,内藤幹彦,出水庸介
    • Organizer
      CBI学会2022年大会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 選択的な標的タンパク質分解技術と創薬2022

    • Author(s)
      内藤幹彦
    • Organizer
      第39回 JBICバイオ関連基盤技術研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] タンパク質分解技術と創薬2022

    • Author(s)
      内藤幹彦
    • Organizer
      ゲノム創薬・創発フォーラム 第10回シンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Targeted protein degradation as a novel strategy for precision medicine against cancers2022

    • Author(s)
      Mikihiko Naito
    • Organizer
      Ubiquitin New Frontier "from Neo-Biology to Targeted Protein Degradation"
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] タンパク質分解技術と創薬2022

    • Author(s)
      内藤幹彦
    • Organizer
      2022年度 文部科学省 学術変革領域研究「先端モデル動物支援プラットフォーム」若手支援技術講習会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Development of a degrader against oncogenic fusion protein FGFR3-TACC32022

    • Author(s)
      Norihito Shibata, Nobuo Cho, Hiroo Koyama, Kazunari Kondo, Mikihiko Naito
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Targeted protein degradation as a novel strategy for precision medicine against cancers2022

    • Author(s)
      Mikihiko Naito
    • Organizer
      Ubiquitin New Frontier from Neo-biology to Targeted Protein Degradation
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Technologies to induce targeted protein degradation and their application for drug development2022

    • Author(s)
      Mikihiko Naito
    • Organizer
      The 95th Annual Meeting of the Japanese Pharmaceutical Society
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] Targeted protein degradation as a novel strategy for precision medicine against cancers2022

    • Author(s)
      Mikihiko Naito
    • Organizer
      The International Symposium in Tokyo 2022, Ubiquitin New Frontier
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] p210 BCR-ABL PHドメインを標的とした新規ペプチド性CML治療薬の開発2022

    • Author(s)
      池上葵、高橋美帆、長田雅也、島崎健太郎、柴田識人、内藤幹彦、西川喜代孝
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Targeted protein degradation by chimeric molecules, PROTACs and SNIPERs2022

    • Author(s)
      Mikihiko Naito
    • Organizer
      Korean Society of Biochemistry and Molecular Biology International Conference 2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] E3リガンドに着目したH-PGDS分解誘導剤の構造活性相関研究2022

    • Author(s)
      大澤陽,黒原崇,柴田識人,有竹浩介,内藤幹彦,出水庸介
    • Organizer
      第66回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘分子の開発2022

    • Author(s)
      永沼美弥子,大岡伸通,辻村はるな,松野研司,内藤幹彦,井上貴雄,辻厳一郎,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 選択的なタンパク質分解技術と創薬2022

    • Author(s)
      内藤幹彦
    • Organizer
      JBIC研究会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] 選択的な標的タンパク質分解技術と創薬2022

    • Author(s)
      内藤幹彦
    • Organizer
      JBIC研究会「タンパク質分解誘導薬・基礎から創薬応用」
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘導分子の創製2022

    • Author(s)
      永沼美弥子,大岡伸通,松野研司,内藤幹彦,井上貴雄,辻厳一郎,出水庸介
    • Organizer
      ケミカルバイオロジー第16回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] DNAアプタマーを用いたエストロゲン受容体分解誘導剤の開発2022

    • Author(s)
      辻村はるな,辻厳一郎,大岡伸通,井上貴雄,内藤幹彦,出水庸介
    • Organizer
      第66回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Development of Gilteritinib-based chimeric small molecules that potently induce degradation of FLT3-ITD protein.2022

    • Author(s)
      Ohoka N, Suzuki M, Uchida T, Tsuji G, Tsukumo Y, Yoshida M. Inoue T., Demizu Y, Ohki H, Naito M.
    • Organizer
      Development of Gilteritinib-based chimeric small molecules that potently induce degradation of FLT3-ITD protein.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Development of chimeric molecules that degrade the estrogen receptor using decoy oligonucleotide ligands2022

    • Author(s)
      Naganuma M, Ohoka N, Tsuji G, Matsuno K, Naito M, Inoue T, Demizu Y.
    • Organizer
      The 49th International Symposium on Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands2022

    • Author(s)
      Nobumichi Ohoka, Mikihiko Naito
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] H-PGDS分解誘導剤のリンカー構造に着目した構造活性相関研究2022

    • Author(s)
      黒原崇,大澤陽,伊藤貴仁,柴田識人,有竹浩介,内藤幹彦,出水庸介
    • Organizer
      ケミカルバイオロジー第16回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] H-PGDS分解誘導剤の構造活性相関研究2022

    • Author(s)
      村上優貴,黒原崇,横尾英知,伊藤貴仁,柳瀬雄太,柴田識人,有竹浩介,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Development of Highly Selective Anti-Cancer Drugs by Targeted Protein Degradation.2021

    • Author(s)
      Mikihiko Naito
    • Organizer
      The 44th Annual Meeting of the Molecular Biology Society of Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] プロテインノックダウン法の現状と課題2021

    • Author(s)
      内藤幹彦
    • Organizer
      日本ケミカルバイオロジー学会産学連携委員会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] Targeted Protein Degradation技術と創薬2021

    • Author(s)
      内藤幹彦
    • Organizer
      CBI学会 第424回研究講演会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 標的タンパク質を分解するプロテインノックダウン技術2021

    • Author(s)
      内藤幹彦
    • Organizer
      第99回産研テクノサロン
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] 高活性・高選択的な造血器型プロスタグランジンD合成酵素分解誘導剤の開発2021

    • Author(s)
      横尾英知,柴田識人,遠藤彬則,伊藤貴仁,柳瀬雄太,村上優貴,藤井清永,大庭誠,佐伯泰,内藤幹彦,有竹浩介,出水庸介
    • Organizer
      ケミカルバイオロジー第15回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Development of Highly Selective Anti-Cancer Drugs by Targeted Protein Degradation.2021

    • Author(s)
      Mikihiko Naito
    • Organizer
      The 44th Annual Meeting of the Molecular Biology Society of Japan
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 標的タンパク質分解薬のoverview2021

    • Author(s)
      内藤幹彦
    • Organizer
      第40回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] Development of Highly Selective Anti-Cancer Drugs by Targeted Protein Degradation2021

    • Author(s)
      内藤幹彦
    • Organizer
      第44回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] タンパク質の選択的分解技術と細胞機能制御2021

    • Author(s)
      内藤幹彦
    • Organizer
      千里ライフサイエンスセミナーP5
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 標的タンパク質を分解するプロテインノックダウン技術2021

    • Author(s)
      内藤幹彦
    • Organizer
      第99回産研テクノサロン
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 標的タンパク質分解薬のoverview2021

    • Author(s)
      内藤幹彦
    • Organizer
      第40回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] 化合物による標的タンパク質の選択的分解2021

    • Author(s)
      内藤幹彦
    • Organizer
      第25回日本がん分子標的治療学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 造血器型プロスタグランジンD合成酵素を標的とした選択的タンパク質分解誘導剤の開発2021

    • Author(s)
      柴田識人,横尾英知,遠藤彬則,伊藤貴仁,栁瀨雄太,村上優貴,藤井清永,佐伯泰,内藤幹彦,有竹浩介,出水庸介
    • Organizer
      第94回日本生化学大会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] アゴニストリガンドを利用したLXR分解誘導剤の開発2021

    • Author(s)
      許涵喬,辻厳一郎,大岡伸通,内藤幹彦,出水庸介
    • Organizer
      第65回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Peptide stapling improves the sustainability of peptide-based degraders against estrogen receptors2021

    • Author(s)
      横尾英知,大岡伸通,大庭誠,伊藤貴仁,井上貴雄,内藤幹彦,出水庸介
    • Organizer
      第58回ペプチド討論会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Discovery of a highly potent and selective PROTAC targeting hematopoietic prostaglandin D synthase via in silico design2021

    • Author(s)
      Yokoo, H., Shibata, N., Endo, A., Ito, T., Yanase, Y., Murakami, Y., Fujii, K., Saeki, Y., Naito, M., Aritake, K., Demizu, Y.
    • Organizer
      AIMECS2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 化合物による標的タンパク質の選択的分解2021

    • Author(s)
      内藤幹彦
    • Organizer
      第25回日本がん分子標的治療学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] Targeted Protein Degradation技術と創薬2021

    • Author(s)
      内藤幹彦
    • Organizer
      CBI学会 第424回研究講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02777
  • [Presentation] タンパク質の選択的分解技術と細胞機能制御2021

    • Author(s)
      内藤幹彦
    • Organizer
      千里ライフサイエンスセミナーP5細胞死研究の新展開
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] 標的タンパク質分解薬のoverview2021

    • Author(s)
      内藤幹彦
    • Organizer
      第40回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Targeted Protein Degradation by Small Molecules2020

    • Author(s)
      Mikihiko Naito
    • Organizer
      第79回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] SNIPERを用いたユビキチンプロテアソーム創薬2020

    • Author(s)
      内藤幹彦
    • Organizer
      第93回日本薬理学会年会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] SNIPER化合物によるケミカルプロテインノックダウン技術の開発と細胞制御2020

    • Author(s)
      内藤幹彦
    • Organizer
      日本化学会第100春期年会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] 核内受容体分解誘導ペプチドの創製2020

    • Author(s)
      横尾英知,大岡伸通,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Targeted Protein Degradation by Small Molecules2020

    • Author(s)
      Mikihiko Naito
    • Organizer
      第79回日本癌学会総会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 化合物による標的タンパク質分解技術と創薬2020

    • Author(s)
      内藤幹彦
    • Organizer
      第69回バイオインターフェイス
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 細胞内の標的タンパク質を特異的に分解するプロテインノックダウン技術の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      日本薬学会第35回創薬セミナー
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 新しいユビキチンリガーゼを利用して標的タンパク質を分解するキメラ化合物の開発2019

    • Author(s)
      大岡伸通、辻厳一郎、正田卓司、藤里卓磨、栗原正明、出水庸介、内藤幹彦
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] SNIPER化合物によるプロテインノックダウン2019

    • Author(s)
      内藤幹彦
    • Organizer
      第42回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Development of amphipathic cell-penetrating foldamers for delivery of biomacromolecules2019

    • Author(s)
      Misawa T, Ohoka N, Goto C, Oba M, Tanaka M, Naito M, Demizu Y.
    • Organizer
      European Symposium on Organic Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] キメラ型タンパク質分解薬SNIPERの開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      日本薬学会第139年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 次世代の医薬品開発プラットフォーム技術:プロテインノックダウン法の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      東北大学大学院薬学系研究科医薬品開発研究センターキックオフシンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Development of cell-penetrating foldamers for delivery of biomacromolecules2019

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第56回ペプチド討論会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] IAPを利用して細胞内の標的タンパク質を分解するプロテインノックダウン技術の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      第28回日本Cell Death学会学術集会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation.2019

    • Author(s)
      Mikihiko Naito
    • Organizer
      Symposium on Frontier in PROTAC Drug Discovery and Development
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] キメラ型タンパク質分解薬SNIPERの開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      日本薬学会第139年会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] 化合物による標的タンパク質分解技術と創薬2019

    • Author(s)
      内藤幹彦
    • Organizer
      第69回バイオインターフェイス
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation.2019

    • Author(s)
      Mikihiko Naito
    • Organizer
      第78回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 細胞内の標的タンパク質を特異的に分解するプロテインノックダウン技術の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      日本再生医療
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] A novel strategy for destabilizion of oncogenic fusion protein BCR-ABL to inhibit the growth of chronic myelogenous leukemea2019

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Mikihiko Naito
    • Organizer
      日本薬学会第139年会 国際創薬シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 細胞膜高透過性ペプチドフォルダマーの開発とDDSキャリアへの応用2019

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] SNIPERs: Hijacking IAP Ubiquitin Ligases for Targeted Protein Degradation2019

    • Author(s)
      Mikihiko Naito
    • Organizer
      2nd Annual Targeted Protein Degradation Summit
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 標的タンパク質を特異的に分解するハイブリッド型低分子化合物SNIPERの開発と応用2019

    • Author(s)
      内藤幹彦
    • Organizer
      第24回日本病態プロテアーゼ学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 細胞内の標的タンパク質を特異的に分解するプロテインノックダウン技術の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      日本再生医療学会 第1回秋季科学シンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Induced Protein Degradation by Chimeric Small Molecules; Recent Progress and Outlook2019

    • Author(s)
      Mikihiko Naito
    • Organizer
      Targeted Protein Degradation forum in Japan
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] 次世代の医薬品開発プラットフォーム技術:プロテインノックダウン法の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      東北大学大学院薬学系研究科医薬品開発研究センターキックオフシンポジウム
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation2019

    • Author(s)
      Mikihiko Naito
    • Organizer
      2nd Annual Targeted Protein Degradation Summit
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] 細胞内の標的タンパク質を特異的に分解するプロテインノックダウン技術の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      日本薬学会第35回創薬セミナー
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] 標的タンパク質を特異的に分解するハイブリッド型低分子化合物SNIPERの開発と応用2019

    • Author(s)
      内藤幹彦
    • Organizer
      第24回日本病態プロテアーゼ学会学術集会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] Induced Protein Degradation by Chimeric Small Molecules; Recent Progress and Outlook.2019

    • Author(s)
      Mikihiko Naito
    • Organizer
      Targeted Protein Degradation forum in Japan
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 生体高分子を効率的に細胞内へ輸送する細胞膜高透過性フォルダマーの開発2019

    • Author(s)
      三澤隆史,大岡伸通,後藤千尋,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      ケミカルバイオロジー第14回年会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] SNIPER化合物によるプロテインノックダウン2019

    • Author(s)
      内藤幹彦
    • Organizer
      第42回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] 生体分子を細胞内に輸送する細胞膜透過性ペプチドフォルダマーの開発2019

    • Author(s)
      三澤隆史,大岡伸通,後藤千尋,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 生体高分子を細胞内に効率的に輸送するキャリアペプチドの開発2019

    • Author(s)
      三澤隆史,大岡伸通,後藤千尋,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第35回日本DDS学会学術集会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] IAPを利用して細胞内の標的タンパク質を分解するプロテインノックダウン技術の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      第28回日本Cell Death学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation2019

    • Author(s)
      Mikihiko Naito
    • Organizer
      Symposium on Frontier in PROTAC Drug Discovery and Development
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] SNIPERによるプロテインノックダウン技術の開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      理研第4回DMP創薬ワークショップ
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] Derivatization of IAP ligand to develop SNIPERs with improved protein knockdown and antitumor activity2018

    • Author(s)
      Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Mikihiko Naito
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] SNIPERによるプロテインノックダウン技術の開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      理研第4回DMP創薬ワークショップ
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] Development of Protein Knockdown Technology to Induce Selective Degradation of Target Proteins2018

    • Author(s)
      Mikihiko Naito
    • Organizer
      薬物動態懇話会第41回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2018

    • Author(s)
      Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, Kenichiro Shimokawa, Tomoya Sameshima, Nobumichi Ohoka, Takayuki Hattori, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Development of Protein Knockdown Technology to Induce Selective Degradation of Target Proteins2018

    • Author(s)
      Mikihiko Naito
    • Organizer
      薬物動態懇話会第41回年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] A novel strategy for destabilizion of oncogenic fusion protein BCR-ABL to inhibit the growth of chronic myelogenous leukemea2018

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Mikihiko Naito
    • Organizer
      日本薬学会第139年会 国際創薬シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook2018

    • Author(s)
      Mikihiko Naito
    • Organizer
      EFMC-ISMC 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 標的タンパク質を分解するプロテインノックダウン技術の開発と創薬への応用2018

    • Author(s)
      内藤幹彦
    • Organizer
      第62回日本薬学会関東支部大会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook2018

    • Author(s)
      Mikihiko Naito
    • Organizer
      EFMC-ISMC 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] IAPのユビキチンリガーゼ活性を利用した標的蛋白質分解誘導剤SNIPERの開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      日経バイオテクプロフェッショナルセミナー 低分子薬の新たなモダリティ:標的蛋白質分解誘導薬の最前線
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 標的タンパク質を分解するプロテインノックダウン技術の開発と創薬への応用2018

    • Author(s)
      内藤幹彦
    • Organizer
      第62回日本薬学会関東支部大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] SNIPERによるプロテインノックダウン技術の開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      理研第4回DMP創薬ワークショップ
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] IAPによる細胞死・細胞周期制御とIAPのユビキチンリガーゼ活性を利用したプロテインノックダウン法の開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      日本がん分子標的治療学会 鶴尾隆賞 受賞講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook2018

    • Author(s)
      Mikihiko Naito
    • Organizer
      EFMC-ISMC 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinases2018

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] A novel strategy for destabilizion of oncogenic fusion protein BCR-ABL to inhibit the growth of chronic myelogenous leukemea2018

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Mikihiko Naito
    • Organizer
      日本薬学会第139年会 国際創薬シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] 標的タンパク質を分解するプロテインノックダウン技術の開発と創薬への応用2018

    • Author(s)
      内藤幹彦
    • Organizer
      第62回日本薬学会関東支部大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 新しいユビキチンリガーゼを利用して標的タンパク質を分解するキメラ化合物の開発2018

    • Author(s)
      大岡伸通、辻厳一郎、正田卓司、藤里卓磨、栗原正明、出水庸介、内藤幹彦
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Development of Protein Knockdown Technology to Induce Selective Degradation of Target Proteins2018

    • Author(s)
      Mikihiko Naito
    • Organizer
      薬物動態懇話会第41回年会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] Derivatization of IAP ligand to develop SNIPERs with improved protein knockdown and antitumor activity2018

    • Author(s)
      Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Mikihiko Naito
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 標的タンパク質を分解する新しい創薬技術、プロテインノックダウン法の開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      第91回日本内分泌学会学術総会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] キメラ型タンパク質分解薬SNIPERの開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      日本薬学会第139年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinases2018

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] IAPを利用したプロテインノックダウン法の開発とがん原性タンパク質の分解2018

    • Author(s)
      内藤幹彦、大岡伸通、柴田識人、服部隆行
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Inducing target-specific protein degradation by SNIPER compounds recruiting IAP ubiquitin ligases2018

    • Author(s)
      Mikihiko Naito
    • Organizer
      第41回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] In vivo protein knockdown by chimeric small-compound SNIPERs.2018

    • Author(s)
      Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Ikuo Fujimori, Masahiro Ito, Youji Hayase, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Tomoya Samejima, Osamu Sano, Ryokichi Koyama, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] IAPのユビキチンリガーゼ活性を利用した標的蛋白質分解誘導剤SNIPERの開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      日経バイオテクプロフェッショナルセミナー 低分子薬の新たなモダリティ:標的蛋白質分解誘導薬の最前線
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] Inducing target-specific protein degradation by SNIPER compounds recruiting IAP ubiquitin ligases2018

    • Author(s)
      Mikihiko Naito
    • Organizer
      第41回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 標的タンパク質を分解する新しい創薬技術、プロテインノックダウン法の開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      第91回日本内分泌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] IAPによる細胞死・細胞周期制御とIAPのユビキチンリガーゼ活性を利用したプロテインノックダウン法の開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      日本がん分子標的治療学会 鶴尾隆賞 受賞講演
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497
  • [Presentation] ペプチドリガンドを利用した標的タンパク質分解誘導剤の開発2018

    • Author(s)
      出水庸介,三澤隆史,大岡伸通,服部隆行,内藤幹彦
    • Organizer
      第 44 回反応と合成の進歩 シンポジウム
    • Data Source
      KAKENHI-PLANNED-18H05502
  • [Presentation] 低コピーEGFR L858R変異アレルを有する細胞の作製とEGFR阻害剤感受性の解析2017

    • Author(s)
      築茂由則、鈴木孝昌、内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] IAPアンタゴニストLCL161誘導体を導入したSNIPERによる効果的なプロテインノックダウン2017

    • Author(s)
      大岡伸通、奥平桂一郎、伊東昌宏、永井克典、柴田識人、服部隆行、宇治川治、下川賢一郎、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第21回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Degradation of target proteins by SNIPER compounds recruiting IAP ubiquitin ligases2017

    • Author(s)
      Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
    • Organizer
      EMBO conference Ubiquitin and SUMO
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017

    • Author(s)
      沖津航陽,服部隆行,出水庸介,三澤隆史,正田卓司,内藤幹彦,栗原正明
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] IAPアンタゴニストLCL161誘導体を導入したSNIPERによる効果的なプロテインノックダウン2017

    • Author(s)
      大岡伸通、奥平桂一郎、伊東昌宏、永井克典、柴田識人、服部隆行、宇治川治、下川賢一郎、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第21回日本がん分子標的治療学会 学術集会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Protein knockdown by SNIPER compounds recruiting IAP ubiquitin ligases2017

    • Author(s)
      Mikihiko Naito
    • Organizer
      2017 Chinese Medicinal Chemistry Symposium, CPA-EFMC International Symposium on Medicinal Chemistry
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] プロテインノックダウン法を利用したアンドロゲン受容体蛋白質分解誘導剤の開発2017

    • Author(s)
      柴田識人、大岡伸通、服部隆行、永井克典、伊東昌宏、奈良洋、長展生、内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Targeting the allosteric site of oncogenic BCR-ABL protein as an alternative strategy for effective protein degradation2017

    • Author(s)
      Norihito Shibata, Kenichiro Shimokawa, Tomoya Sameshima, Naoki Miyamoto, Osamu Ujikawa, Hiroshi Nara, Nobumichi Ohoka, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通、永井克典、奥平桂一郎、柴田識人、服部隆行、長展生、内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Targeting the allosteric site of oncogenic BCR-ABL protein as an alternative strategy for effective protein degradation2017

    • Author(s)
      Norihito Shibata, Kenichiro Shimokawa, Tomoya Sameshima, Naoki Miyamoto, Osamu Ujikawa, Hiroshi Nara, Nobumichi Ohoka, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] NCCオンコパネルの90遺伝子を網羅する変異細胞株パネルの作製2017

    • Author(s)
      鈴木孝昌、築茂由則、内藤幹彦、小原有弘
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] In vivo protein knockdown by chimeric small-compound SNIPERs.2017

    • Author(s)
      Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Ikuo Fujimori, Masahiro Ito, Youji Hayase, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Tomoya Samejima, Osamu Sano, Ryokichi Koyama, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] IAPを利用したプロテインノックダウン法の開発とがん原性タンパク質の分解2017

    • Author(s)
      内藤幹彦、大岡伸通、柴田識人、服部隆行
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] 低コピーEGFR L858R変異アレルを有する細胞の作製とEGFR阻害剤感受性の解析2017

    • Author(s)
      築茂由則、鈴木孝昌、内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Degradation of oncogenic proteins by SNIPER compounds.2017

    • Author(s)
      Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通、永井克典、奥平桂一郎、柴田識人、服部隆行、長展生、内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Degradation of oncogenic proteins by SNIPER compounds.2017

    • Author(s)
      Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] プロテインノックダウン法を利用したアンドロゲン受容体蛋白質分解誘導剤の開発2017

    • Author(s)
      柴田識人、大岡伸通、服部隆行、永井克典、伊東昌宏、奈良洋、長展生、内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017

    • Author(s)
      沖津航陽,服部隆行,出水庸介,三澤隆史,正田卓司,内藤幹彦,栗原正明
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] NCCオンコパネルの90遺伝子を網羅する変異細胞株パネルの作製2017

    • Author(s)
      鈴木孝昌、築茂由則、内藤幹彦、小原有弘
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Degradation of target proteins by SNIPER compounds recruiting IAP ubiquitin ligases2017

    • Author(s)
      Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
    • Organizer
      EMBO conference Ubiquitin and SUMO
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Protein knockdown by SNIPER compounds recruiting IAP ubiquitin ligases2017

    • Author(s)
      Mikihiko Naito
    • Organizer
      2017 Chinese Medicinal Chemistry Symposium, CPA-EFMC International Symposium on Medicinal Chemistry
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2017

    • Author(s)
      Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, Kenichiro Shimokawa, Tomoya Sameshima, Nobumichi Ohoka, Takayuki Hattori, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Development of hybrid small molecules that induce degradation of oncogenic BCR-ABL2016

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016

    • Author(s)
      大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016

    • Author(s)
      大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] 細胞内His タグタンパク質分解誘導剤の開発2016

    • Author(s)
      沖津航陽、服部隆行、出水庸介、三澤隆史、正田卓司、内藤幹彦、栗原正明
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学(東京)
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016

    • Author(s)
      大岡伸通、奥平桂一郎、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Protein knockdown by SNIPER compounds: Application for basic research and cancer therapy2016

    • Author(s)
      Naito M, Hattori T, Ohoka N, Shibata N, Shoda T, Demizu Y, Kurihara M
    • Organizer
      第10回日米がん合同会議
    • Place of Presentation
      ラハイナ
    • Year and Date
      2016-02-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] 低分子化合物による網羅的人工ユビキチン化システムの構築2016

    • Author(s)
      服部隆行、正田卓司、奥平桂一郎、柴田識人、大岡伸通、伊東進、栗原正明、内藤幹彦
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016

    • Author(s)
      大岡伸通、奥平桂一郎、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2016

    • Author(s)
      大岡伸通, 伊東昌宏, 奥平桂一郎, 永井克典, 柴田識人, 服部隆行, 長展生, 内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] 芳香族炭化水素受容体のユビキチンリガーゼ活性を利用した新規標的タンパク質分解誘導剤の開発2016

    • Author(s)
      藤里卓磨、正田卓司、大岡伸通、井上英史、内藤幹彦、栗原正明
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学(東京)
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016

    • Author(s)
      大岡伸通, 奥平桂一郎, 服部隆行, 内藤幹彦
    • Organizer
      第20回日本がん分子標的治療学会
    • Place of Presentation
      大分
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] In vivo protein knockdown by SNIPER recruiting IAP ubiquitin ligases2016

    • Author(s)
      Mikihiko Naito
    • Organizer
      The 21th 国際化学療法シンポジウム
    • Place of Presentation
      日本科学未来館(東京)
    • Year and Date
      2016-12-14
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016

    • Author(s)
      大岡伸通, 柴田識人, 服部隆行, 内藤幹彦
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] がん遺伝子YAPを標的としたプロテインノックダウン法の確立2016

    • Author(s)
      中野なおこ、正田卓司、服部隆行、栗原正明、内藤幹彦、伊東進
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Development of hybrid small molecules that induce degradation of oncogenic BCR-ABL2016

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] 低分子化合物SNIPERによる細胞内ユビキチン化機構の制御と創薬への応用2016

    • Author(s)
      大岡伸通, 奥平桂一郎, 永井克典, 伊東昌宏, 柴田識人, 服部隆行, 宇治川治, 佐野修, 小山亮吉, 今枝泰宏, 奈良洋, 長展生, 内藤幹彦
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] 低分子化合物SNIPERによる細胞内ユビキチン化機能の制御と創薬への利用2016

    • Author(s)
      大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] エストロゲン受容体分解誘導剤の分子デザイン2016

    • Author(s)
      正田卓司,奥平桂一郎,内藤幹彦,栗原正明
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] In vivo protein knockdown by SNIPER recruiting IAP ubiquitin ligases2016

    • Author(s)
      Mikihiko Naito
    • Organizer
      The 21th 国際化学療法シンポジウム
    • Place of Presentation
      日本科学未来館(東京)
    • Year and Date
      2016-12-14
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Protein knockdown by SNIPER compounds, inducers for target protein-selective degradation2015

    • Author(s)
      Naito M
    • Organizer
      The 20th 国際化学療法シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-12-09
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] ユビキチン化誘導剤によるユビキチン関連死の解明2015

    • Author(s)
      大岡伸通, 永井克典, 柴田識人, 服部隆行, 長展生, 内藤幹彦
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] Ubiquitin-related cancer cell death induced by small molecules degrading TACC3 protein.2015

    • Author(s)
      大岡伸通, 柴田識人, 服部隆行, 内藤幹彦
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] Degradation of C-terminally extended proteins by stop codon read-through mutations cause hereditary disorders2015

    • Author(s)
      Shibata N, Ohoka N, Gondo Y, Naito M
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] TACC3分解誘導剤によるがん細胞のユビキチン関連死2015

    • Author(s)
      大岡伸通、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第19回日本がん分子標的治療学会 学術集会
    • Place of Presentation
      松山
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] TACC3分解誘導剤によるがん細胞のユビキチン関連死2015

    • Author(s)
      大岡伸通, 服部隆行, 内藤幹彦
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] Bestatin/tamoxifen hybrid molecule induces proteasomal degradation of estrogen receptor a and necrotic cell death in breast cancer cells.2014

    • Author(s)
      Okuhira K, Demizu Y, Ohoka N, Shibata N, Hattori T, Nishimaki-Mogami T, Kurihara M, Okuda H, Naito M.
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
    • Place of Presentation
      Bigsky
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2014

    • Author(s)
      Ohoka N, Ohata H, Naito M.
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
    • Place of Presentation
      Bigsky
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] Apollon細胞分裂初期においてスピンドルチェックポイント非依存的なcyclin Aの分解を促進する2014

    • Author(s)
      大岡 伸通,大畑 広和,内藤 幹彦
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] エストロゲン受容体分解誘導剤による乳癌の細胞死誘導分子機構2014

    • Author(s)
      奥平 桂一郎,出水 庸介,服部 隆行,大岡 伸通,柴田 識人,最上(西巻) 知子,栗原 正明,奥田 晴宏,内藤 幹彦
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Apollon細胞分裂初期においてスピンドルチェックポイント非依存的なcyclin Aの分解を促進する2014

    • Author(s)
      大岡 伸通,大畑 広和,内藤 幹彦
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2014

    • Author(s)
      Ohoka N, Ohata H, Naito M.
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
    • Place of Presentation
      Bigsky
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン効果の検討2013

    • Author(s)
      奥平 桂一郎,大岡 伸通,最上(西巻) 知子,伊藤 幸裕,石川 稔,橋本 祐一,内藤 幹彦
    • Organizer
      第17回日本がん分子標的治療学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2013

    • Author(s)
      大岡 伸通,大畑 広和,内藤 幹彦
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] Development of SNIPER(ER) that induces estrogen receptor degradation followed by rapid cell death in breast cancer cells2013

    • Author(s)
      Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M.
    • Organizer
      Ninth AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research
    • Place of Presentation
      ラハイナ市、米国
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells2013

    • Author(s)
      Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Nishimaki-Mogami, T, Okuda H, Kurihara M, Naito M.
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Boston
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2013

    • Author(s)
      大岡 伸通,大畑 広和,内藤 幹彦
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン技術の評価2013

    • Author(s)
      奥平桂一郎,大岡伸通,最上(西巻)知子,伊藤幸裕,石川稔,橋本祐一,内藤幹彦
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins2012

    • Author(s)
      Naito, M., Okuhira, K., Ohoka, N., Shibata, N., Hattori, T., Itoh, Y., Ishikawa, M., Hashimoto, Y.
    • Organizer
      The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
    • Place of Presentation
      ヒューストン市、米国
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] プロテインノックダウン法によるエストロゲンレセプターの分解2012

    • Author(s)
      奥平 桂一郎, 出水 庸介, 大岡 伸通, 柴田 識人, 服部 隆行, 最上(西巻) 知子, 栗原 正明, 奥田 晴宏, 内藤 幹彦
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins in a specific manner2012

    • Author(s)
      Naito, M., Okuhira, K., Demizu, Y., Itoh, Y., Ishikawa, M., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Hashimoto, Y.
    • Organizer
      Cell Symposia: Genetics and Chemistry Sharing a Language of Discovery
    • Place of Presentation
      ボストン市、米国
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] プロテインノックダウン法を利用したエストロゲン受容体分解誘導剤の開発2012

    • Author(s)
      元井 宏美, 出水 庸介, 佐藤 由紀子, 奥平 桂一郎, 内藤 幹彦, 栗原 正明
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] 乳癌におけるエストロゲンレセプターの分解を誘導する分子SNIPER(ER)の開発2012

    • Author(s)
      奥平桂一郎, 出水庸介, 大岡伸通, 柴田識人, 服部隆行, 最上(西巻)知子, 奥田晴宏, 栗原正明, 内藤幹彦
    • Organizer
      第16回日本がん分子標的治療学会
    • Place of Presentation
      北九州市
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Degradation of estrogen receptor induced by a small hybrid molecule SNIPER(ER)2012

    • Author(s)
      奥平桂一郎、出水庸介、大岡伸通、柴田識人、服部隆行、最上(西巻)知子、栗原正明、奥田晴宏、内藤幹彦
    • Organizer
      The 16th JFCR-ISCC
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Development of SNIPER(ER) that induces estrogen receptor degradation2012

    • Author(s)
      Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M.
    • Organizer
      The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
    • Place of Presentation
      Houston
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins in a specific manner2012

    • Author(s)
      内藤幹彦
    • Organizer
      Cell Symposia: Genetics and Chemistry Sharing a Language of Discovery
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins2012

    • Author(s)
      Naito, M., Okuhira, K., Ohoka, N., Shibata, N., Hattori, T., Itoh, Y., Ishikawa, M., Hashimoto, Y.
    • Organizer
      The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
    • Place of Presentation
      Houston
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] M.:Development of SNIPER(ER) that induces estrogen receptor degradation2012

    • Author(s)
      Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M.
    • Organizer
      The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
    • Place of Presentation
      ヒューストン市、米国
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Design and Synthesis of ER Degradation Inducer for Protein Knockdown Strategy2011

    • Author(s)
      Yosuke Demizu, Hiromi Motoi, Keiichiro Okuhira, Kiyoshi Fukuhara, Haruhiro Okuda, Mikihiko Naito, and Masaaki Kurihara
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Protein Knockdown: Selective Degradation of Target Proteins in Cells Using Methyl Bestatin-ligand Hybrid Molecules2011

    • Author(s)
      Minoru Ishikawa, Yukihiro Itoh, Risa Kitaguchi, Shinichi Sato, Mikihiko Naito, and Yuichi Hashimoto
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] 抗がん剤、がん分子標的治療薬の作用機序と薬剤耐性の分子機構2011

    • Author(s)
      内藤幹彦
    • Organizer
      第55回日本薬学会関東支部大会(招待講演)
    • Place of Presentation
      船橋
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] プロテインノックダウン法によるエストロゲン受容体の分解2011

    • Author(s)
      奥平桂一郎、出水庸介、大岡伸通、柴田識人、服部隆行、最上(西巻)知子、栗原正明、奥田晴宏、内藤幹彦
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン技術の検討2011

    • Author(s)
      奥平桂一郎、大岡伸通、最上(西巻)知子、伊藤幸裕、石川稔、橋本祐一、内藤幹彦
    • Organizer
      第15回日本がん分子標的治療学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Drug resistance and apoptosis of cancer cells2009

    • Author(s)
      内藤幹彦
    • Organizer
      The 14th JFCR lnternational Symposium on Cancer Chemotherapy
    • Place of Presentation
      日航ホテル(東京)
    • Year and Date
      2009-12-02
    • Data Source
      KAKENHI-PROJECT-20015012
  • [Presentation] Regulation of Cell Death and Cell Cycle by IAPs2009

    • Author(s)
      内藤幹彦
    • Organizer
      第14回分生研シンポジウム
    • Place of Presentation
      東京大学安田講堂
    • Year and Date
      2009-10-28
    • Data Source
      KAKENHI-PROJECT-20058008
  • [Presentation] Small molecules destabilize cIAP1 by activating auto-ubinuitylation2008

    • Author(s)
      Naito M, et.al.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Lucca, Italy
    • Year and Date
      2008-07-10
    • Data Source
      KAKENHI-PROJECT-20015012
  • [Presentation] Small molecules destabilize cIAP1 by activating auto-ubiquitylation2008

    • Author(s)
      Naito M, et.al.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Lucca, Italy
    • Year and Date
      2008-07-10
    • Data Source
      KAKENHI-PROJECT-20058008
  • [Presentation] Molecular function of IAPs and its implication in cancer.2007

    • Author(s)
      内藤幹彦
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-18659017
  • [Presentation] Molecular function of IAPs and its implication in cancer.2007

    • Author(s)
      内藤幹彦
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-18015009
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤によるがん細胞死の誘導.

    • Author(s)
      大岡伸通, 奥平桂一郎, 柴田識人, 服部隆行, 内藤幹彦
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] SNIPER(TACC3) degrades TACC3 protein via the ubiquitin-proteasome pathway and induces apoptosis in cancer cells expressing a large amount of TACC3.

    • Author(s)
      大岡伸通, 永井克典, 奥平桂一郎, 柴田識人, 服部隆行, 長展生, 内藤幹彦
    • Organizer
      26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-11-18 – 2014-11-21
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤による癌細胞死の誘導

    • Author(s)
      大岡伸通,永井克典,奥平桂一郎,柴田識人,服部隆行,長展生,内藤幹彦
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Destabilization of carboxy-terminally extended proteins encoded by stop codon read-through mutation via ubiquitin-proteasome system

    • Author(s)
      柴田 識人,大岡 伸通,櫻庭 喜行,権藤 洋一,内藤 幹彦
    • Organizer
      Symposium for young ubiquitin researchers in Japan“New Era in the Ubiquitin Research”
    • Place of Presentation
      京都
    • Year and Date
      2014-11-11 – 2014-11-12
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤による癌細胞死の誘導.

    • Author(s)
      大岡伸通, 永井克典, 奥平桂一郎, 柴田識人, 服部隆行, 長展生, 内藤幹彦
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤の開発と抗がん活性評価.

    • Author(s)
      大岡伸通, 永井克典, 服部隆行,奥平桂一郎, 柴田識人,長展生, 内藤幹彦
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] SNIPER(TACC3) degrades TACC3 protein via the ubiquitin-proteasome pathway and induces apoptosis in cancer cells expressing a large amount of TACC3.

    • Author(s)
      Nobumichi Ohoka, Katsunori Nagai, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
    • Organizer
      26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-11-18 – 2014-11-21
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] SNIPER: Inducing protein degradation via recruitment to IAP

    • Author(s)
      M. Naito
    • Organizer
      248th ACS National Meeting and Exposition
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-08-10 – 2014-08-14
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Apollon細胞分裂初期においてスピンドルチェックポイント非依存的なcyclin Aの分解を促進する

    • Author(s)
      大岡 伸通,内藤 幹彦
    • Organizer
      日本がん分子標的治療学会第18回学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] Protein Knockdown: Targeted Destruction of Pathogenic Proteins by SNIPER Compounds

    • Author(s)
      M. Naito
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤の開発と抗がん活性評価

    • Author(s)
      大岡伸通、永井克典、服部隆行、奥平桂一郎、柴田識人、長展生、内藤幹彦
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] 終止コドンのリードスルー変異によるユビキチン-プロテアソーム系を介した蛋白質の不安定化

    • Author(s)
      柴田 識人,大岡 伸通,権藤 洋一,内藤 幹彦
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤によるがん細胞死の誘導

    • Author(s)
      大岡伸通,奥平桂一郎,柴田識人,服部隆行,内藤幹彦
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PUBLICLY-25112521
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