Koseki Haruhiko 古関明彦

… Alternative Names

KOSEKI Haruhiko 古関明彦

古関明彦コセキハルヒコ

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Researcher Number	40225446
Other IDs
External Links
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 副センター長 2025: 千葉大学, 大学院医学研究院, 教授
Affiliation (based on the past Project Information) *help	2017 – 2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー 2017: 国立研究開発法人理化学研究所, その他, 研究員 2015 – 2017: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, グループディレクター 2015: 国立研究開発法人理化学研究所, その他部局等, その他 2014: 独立行政法人理化学研究所, その他部局等, その他 … More 2014: 理化学研究所・統合生命医科学研究センター, 免疫器官形成研究グループ, グループディレクター 2013 – 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, グループディレクター 2004 – 2012: 独立行政法人理化学研究所, 免疫器官形成研究グループ, グループディレクター 2011: 独立行政法人理化学研究所, 免疫器官形成研究グループ, グループリーダー 2010: 理化学研究所, 免疫器官形成研究グループ, グループディレクター 2010: 理化学研究所, 免疫器官形成研究グループ・グループディレクター 2006: Niigata University, Graduate School of Medical and Dental Sciences, Professor, 免疫器官形成研究グループ, グループデイレクター 2001 – 2004: Chiba Univeiisity, Graduate School of Medicine, Molecular Embryology, professor, 大学院・医学研究院, 教授 2003: 千葉大学, 大学院・医学研究部, 教授 2002: 千葉大学, 大学院・医学研究科・発生生物学部門, 教授 1998 – 2000: 千葉大学, 大学院・医学研究科, 教授 1999: 千葉大学, 医学部, 教授 1997: 千葉大学, 医学部, 助教授 1996: Chiba University, School of Medicine, Assist. 1994 – 1996: 千葉大学, 医学部, 助手 1995: 千葉大学, 医科部, 助手 1991: 千葉大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / General medical chemistry / General anatomy (including Histology/Embryology) / Transformative Research Areas, Section (III) / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological Sciences / General medical chemistry / Experimental pathology Except Principal Investigator Biological Sciences / Hematology … More / Laboratory animal science / Biomedical engineering/Biological material science / Pathological medical chemistry / Cell biology / Anesthesiology/Resuscitation studies / Ophthalmology / Immunology / Genome biology / Developmental biology / Stem cell biology and medical science / Human genetics / Pediatric surgery / Neuroscience in general / Developmental biology Less
Keywords	Principal Investigator ポリコーム群 / Hox / クロマチン / マウス / ポリコム群 / Bmi1 / Mel18 / スプライセオソーム / 哺乳類 / CpGアイランド … More / Ring1 / Mph2 / ホメオボックス / bmi-1 / mel-18 / Edr1 / Rnf2 / Polycomb / p53 / Pax-1 / PRC2 / PRC1 / ヒストン / ノックアウトマウス / 細胞死 / 脊索 / ライブセルイメージング / 細胞分化 / 3次元ゲノム動態 / DNAメチル化 / 細胞運命決定 / DNA複製 / クロマチン複製 / 複製フォーク / 遺伝子発現 / 発現制御 / ゲノム / RNF20 / NP95/UHRF1 / ポリコム群遺伝子 / DNMT1 / Histon H3 / Mouse / DNAダメージ / Topors / ヒストンH3 / Edr2 / Cbx2 / Pc12 / translational regulation / cellular senescence / knockout / 細胞死制御 / Mel-18 / プログラム細胞死 / ホメオプロテインインターラクティングキナーゼ / E2F6複合体 / MBLR / ユビキチン化 / ヒストンH2A / X染色体 / Ring1B / 胎児性繊維芽細胞 / Ink4a / Pcl2 / 翻訳制御 / 細胞老化 / ノックアウト / notochord / sclerotome / dorsovental axis / vertebral column / コラーゲン(α1) / 体節分化 / 硬節 / 腹背軸 / 脊椎骨 / Np95/UHRF1 / Cxxc5 / SRAドメイン / CXXCモチーフ / エピジェネティクス / CpG配列 / ユビキチン / 4 / Oct3 / 転写制御 / ES細胞 / ヘテロクロマチンタンパク-1(HP1γ) / HP1_γ / ヘテロクロマチ / エピジェネティック制御 / 性染色体不活性化 / 精母細胞 / HP1γ / ヒストンアセチル化 / Tip60 / Epc1 / 対合 / ヒストン修飾 / セントロメア / ヘテロクロマチン / 減数分裂 / 精子形成 / 間充織 / 胃 / Fkh6 / リンホトキシン / パイエル板 / 腸管付随リンパ組織 / FKH6 / Th2 / 尾芽 / MPH2 / 細胞死抑制 / 前後軸形成 / リンパ球前駆細胞増殖 / IL-7 / ホメオテイック変異 / 欠失マウス / ポリコ-ム遺伝子 / モノクローナル抗体 / スクレロトーム分化 / ウズラPax-1 / 脊椎形成 … More Except Principal Investigator クロマチン / ポリコーム群 / エピジェネティクス / ヒストン修飾 / ポリコーム / ノックアウトマウス / Hox / 転写因子 / 分子シャペロン / PTFE / Rlp7p / E6 / HPV / COPI / KDEL receptor / VP22 / HSP27 / AGM / SLE / Biosensor / NMR / 遺伝子変異 / マウスモデル / 骨髄異形成症候群 / 転写抑制 / 分化 / 転写制御 / ES細胞 / 幹細胞 / Mel-18 / スプライセオソーム / 小胞体 / DDX41 / 新規遺伝子変異 / 遺伝子改変マウス / 急性骨髄性白血病 / ethyl nitrosourea / induced mutation / gene function / genome function / reverse genetics / mouse / mutagenesis / 標的遺伝子変異体 / モデル動物 / エチルニトロソウレア / 突然変異誘発 / 遺伝子機能 / ゲノム機能 / 逆遺伝学 / マウス / ミュータジェネシス / Tissue Engineering / Fibronectin / Artificial ECM / Growth Factor / Peripheral Blood MNC / CD34 positive cells / Bone Marrow Cell / VEGF / 組織工学 / フィブロネクチン / 人工細胞外マトリックス / 細胞増殖因子 / 末梢血単核球細胞 / CD34陽性細胞 / 骨髄細胞 / ribosome related protein / anchorage dependence / リボゾーム関連タンパク質 / 足場依存性 / chaperone / ER / Golgi / CopI / ゴルジ体 / molecular chaperone / stress protein / 分泌 / 細胞保護 / 酸化ストレス / heat shock protein / ストレス蛋白 / Transcriptional factor / Crystallin gene / Polycomb genes / Transgenics / B cell / Immunological tolerance / T cell / 有機リン系農薬センサー / 水晶体特異的遺伝子発現 / ポリコ-ム遺伝子 / 発生工学 / B細胞 / 免疫寛容 / T細胞 / electrophysiology / rejection / retinitis pigmentosa / retinal pigment epithelium transplantation / 網膜色素上皮移植 / 拒絶反応 / 網膜変性症 / 網膜色素上皮細胞移植 / Extrathymic development / Invariant Valpha14 / Valpha14 NK T cells / Autoimmune disease / 受容体遺伝子再構成 / 胎児肝 / 均一な抗原受容体 / 胸腺外分化 / Vα14T細胞 / 胸腺外T細胞分化 / invariant TCR / 胎生初期分化 / Vα14NKT細胞 / 自己免疫病 / Protein interaction / Gene targeting / Higher plants / Morphogenesis / Cre-loxP / Fission yeast / 植物 / 胚形成 / 蛋白高次機能構造 / 遺伝子ターゲティング / RNAプロセシング / バイオモニタリング / DNA再複製 / 細胞周期 / 温度感受性突然変異体 / ATPase / 免疫病 / 免疫系 / バイオセンサー / 分子相互作用 / 遺伝子標的 / 高等植物 / 形態形成 / Cre-IoxP / 分裂酵母 / ゲノムシーケンス / クローン進化 / コヘシン / スプライシング因子 / 二次性白血病 / 血液腫瘍学 / 血液内科学 / ゲノム / 病態モデルマウス / 発生・分化 / 機能ゲノム / 動物 / 遺伝子 / ゲノム操作技術 / ゲノム編集 / 遺伝子改変動物 / 染色体工学 / 有用遺伝子探索 / 病態モデル動物 / 部位特異的組み換え / バイオテクノロジー / 多分化能 / 大脳皮質発生 / 神経幹細胞 / ユビキチン化ヒストンH2A / 細胞分化 / 初期発生 / 胚性幹細胞 / 発生 / 転写 / LIT1刷り込みドメイン / KIP2 / siRNAライブラリー / non-coding RNA / 刷り込みドメイン / ゲノム刷り込み / SUMO / ポリコム群 / Scmh1 / メチル化ヒストンH3K9 / ポリコム群複合体 / パキテン期 / XY体 / ユビキチンライゲース / ヒストン / 未分化 / 幹細胞移植 / 子宮内胎児移植 / マイクロアレイ / 肝細胞 / プログラム細胞死 / huntingtin / アミノ酸配列 / 微小管 / 情動 / 海馬 / 扁桃体 / 抗体 / cDNA / データベース / p53 / 細胞死制御 / 発がん / 染色体免疫沈降 / ホメオボックス / 核マトリックス / Ring1B / Th2細胞 / リンパ球 / 核マトリクス / Th2分化 / DES / Bmi1 / Mel18 / NF-IL-6 / マクロファージ / AP-1 / c-fos / 造血幹細胞 / 情報収集 / 会議開催 / 分節パターン / 企画・調査 / 科学研究費補助金特定領域(B) / アポトーシス / IL-5 / トランスジェニックマウス / BAZF / BCL6 / COPI 小胞 / KDEL レセプター / 蛋白質品質管理機構 / TCRV領域 / T細胞抗原受容体 / PCR / 腫瘍内T細胞レパトア Less

機動性DNAエレメントとCpGアイランドの相互作用による表現型揺らぎのメカニズム解明Principal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
ポリコムによる分化と共役するゲノム高次構造制御の分子機構解明Principal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of the replication mechanism of repression domains by Polycomb groupPrincipal Investigator
- Principal Investigator
  
  Koseki Haruhiko
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
Towards understanding the role for DNMT1 to establish Polycomb-mediated gene silencingPrincipal Investigator
- Principal Investigator
  
  Koseki Haruhiko
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Institute of Physical and Chemical Research
Biological characterization of DDX41 germline and somatic mutations in myeloid neoplasms
- Principal Investigator
  
  Kon Ayana
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
Molecular pathogenesis in myelodysplastic syndromes (MDS).
- Principal Investigator
  
  OGAWA SEISHI
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
New site-specific recombination systems for genome engineering, VCre/VloxP and SCre/SloxP
- Principal Investigator
  
  NAKAYAMA MANABU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genome biology
- Research Institution
  Kazusa DNA Research Institute
The role of CpG dinucleotides to generate PcG-repressive genomic domainsPrincipal Investigator
- Principal Investigator
  
  KOSEKI HARUHIKO
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Institute of Physical and Chemical Research
Epigenetic regulation of embryonic and somatic stem cells by Polycomb
- Principal Investigator
  
  ENDOH Mitsuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Stem cell biology and medical science
- Research Institution
  The Institute of Physical and Chemical Research
Temporal regulation of cortical neural precursor cell fate by polycomb group proteins
- Principal Investigator
  
  HIRABAYASHI Yusuke
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  The University of Tokyo
Epigenetic regulation of mammalian spermatogenesisPrincipal Investigator
- Principal Investigator
  
  KOSEKI Haruhiko
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Dissecting molecular mechanisms mediated by Polycomb group proteins in maintenance and differentiation of ES cellsPrincipal Investigator
- Principal Investigator
  
  KOSEKI HARUHIKO
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The Institute of Physical and Chemical Research
Identification of regulatory factors for genomic imprinting using siRNA library
- Principal Investigator
  
  SOEJIMA Hidenobu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Saga University
XY体形成過程におけるほ乳類ポリコム群の機能発現メカニズムの解明
- Principal Investigator
  
  TAKADA Yuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
哺乳類ポリコーム群遺伝子によるES細胞の未分化性維持・分化の制御機構の解明
- Principal Investigator
  
  MITSUHIRO Endoh
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Development of mutant mice carrying base-substitutions in target genes.
- Principal Investigator
  
  GONDO Yoichi
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  RIKEN
哺乳類ポリコーム群による細胞増殖と細胞死制御の分子機序
- Principal Investigator
  
  青江知彦
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
幹細胞移植による子宮内胎児治療法の確立に関する研究
- Principal Investigator
  
  鈴木盛一
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatric surgery
- Research Institution
  National Research Institute for Child Health and Development
Association of mammalian PcG multimeric protein complexes to Hoxb8 genePrincipal Investigator
- Principal Investigator
  
  KOSEKI Haruhiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Chiba University
The analysis of a novel gene E6DG1 function involving in anchorage dependency
- Principal Investigator
  
  SHIRASAWA Hiroshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Chiba University
Bone Marrow Cell Culture for Producing Tissue Engineered Regenerative Blood Vessels as a Goal of Clinical Application
- Principal Investigator
  
  ISHIDA Atsushi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Chiba University
哺乳類ポリコーム群によるリンパ球機能のコントロール
- Principal Investigator
  
  青江知彦
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
哺乳類ポリコーム群が構成する核内機能ドメインの作用発現機序の解析
- Principal Investigator
  
  磯野協一
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
哺乳類ポリコーム群による細胞増殖と細胞死制御の分子機序
- Principal Investigator
  
  青江知彦
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
ヒト脳内長鎖cDNA解析データベースを基盤としたマウス扁桃体の情動神経機構の解明
- Principal Investigator
  
  湯浅茂樹
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neuroscience in general
- Research Institution
  National Center of Neurology and Psychiatry
  Chiba University
Molecular mechanisms that integrate 'cell death and cell cycle progression.Principal Investigator
- Principal Investigator
  
  KOSEKI Haruhiko
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  RIKEN
  Chiba University
脳のパターン形成と細胞死抑制の課程における哺乳類ポリコーム群の機能発現機序Principal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
ポリコーム遺伝子Mel-18とBim-1の前後軸形成における機能Principal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
AP-1遺伝子群による造血制御
- Principal Investigator
  
  岡田誠治
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
免疫細胞の分化と増殖における哺乳類ポリコーム群の機能発現機序Principal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
ポリコーム群が構成する核内機能ドメインの機能発現機序Principal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
哺乳類ポリコーム群による細胞増殖と細胞死制御機序の解明Principal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
内分泌かく乱物質による晩発障害発生の分子メカニズムの解析
- Principal Investigator
  
  赤坂武
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Chiba University
胃機能発現の分子メカニズムの解析Principal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
The KDEL receptor and vesicular traffic
- Principal Investigator
  
  AOE Tomohiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  CHIBA UNIVERSITY
ポリコーム群遺伝子Mel-18とBmi-1の前後軸形成における機能Principal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
小胞体分子シャペロンによる細胞内蛋白質輸送の制御
- Principal Investigator
  
  AOE Tomohiko
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
転写抑制因子(BCL6遺伝子群とポリコーム遺伝子群)による造血制御
- Principal Investigator
  
  岡田誠治
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
脊椎動物の分節性の分枝基盤とその進化
- Principal Investigator
  
  高橋淑子
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Nara Institute of Science and Technology
A new approach for cellular injury
- Principal Investigator
  
  AOE Tomohiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Chiba University
脊椎動物・ポリコーム遺伝子産物による前後軸形成のコントロールPrincipal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
ポリコ-ム遺伝子Mel-18とBmi-1の前後軸形成における機能Principal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University, School of Medicine
Research of inhibition in rejection of retinal pigment epithelium transplantation
- Principal Investigator
  
  ADACHI Emiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Chiba University
Functional analysis of roles of Pax-1 during vertebral column developmentPrincipal Investigator
- Principal Investigator
  
  KOSEKI Haruhiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Chiba University, School of Medicine
脊椎形成を統御する転写活性化因子Pax-1遺伝子の発現調節機構Principal Investigator
- Principal Investigator
  
  古関明彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Chiba University
胸腺外T細胞初期分化
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Chiba University School of Medicine
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University
がんの免疫系からのエスケ-プ機構
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Chiba University

[Book] ヒストンH2Aのユビキチン化による遺伝子発現の制御生体の科学60巻2009
- Author(s)
  遠藤充浩、古関明彦
- Data Source
  KAKENHI-PROJECT-21602006
[Journal Article] Polycomb-mediated histone modifications and gene regulation2024
- Author(s)
  Shinsuke Ito, Takashi Umehara, Haruhiko Koseki.
- Journal Title
  
  Biochem Soc Trans
  
  Volume: 1 Issue: 1 Pages: 151-161
- DOI
  10.1042/bst20230336
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K05736, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-20H03388
[Journal Article] PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression2024
- Author(s)
  Del Vecchio A, Mule P, Fernandez-Perez D, Amato S, Lattanzi G, Zanotti M, Rustichelli S, Pivetti S, Oldani P, Mariani A, Iommazzo F, Koseki H, Facciotti F, Tamburri S, Ferrari KJ, Pasini D.
- Journal Title
  
  Developmental Cell
  
  Volume: 59 Issue: 3 Pages: 368-383.e7
- DOI
  10.1016/j.devcel.2023.12.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745
[Journal Article] Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure2023
- Author(s)
  Oka Masahiro、Otani Mayumi、Miyamoto Yoichi、Oshima Rieko、Adachi Jun、Tomonaga Takeshi、Asally Munehiro、Nagaoka Yuya、Tanaka Kaori、Toyoda Atsushi、Ichikawa Kazuki、Morishita Shinichi、Isono Kyoichi、Koseki Haruhiko、Nakato Ryuichiro、Ohkawa Yasuyuki、Yoneda Yoshihiro
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 8 Pages: 112884-112884
- DOI
  10.1016/j.celrep.2023.112884
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0111, KAKENHI-PROJECT-22K19275, KAKENHI-PLANNED-19H05745, KAKENHI-PUBLICLY-22H04676, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23H00372, KAKENHI-PROJECT-23K27373
[Journal Article] Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages2023
- Author(s)
  Masui Osamu、Corbel Catherine、Nagao Koji、Endo Takaho A.、Kezuka Fuyuko、Diabangouaya Patricia、Nakayama Manabu、Kumon Mami、Koseki Yoko、Obuse Chikashi、Koseki Haruhiko、Heard Edith
- Journal Title
  
  Nature Cell Biology
  
  Volume: 25 Issue: 1 Pages: 134-144
- DOI
  10.1038/s41556-022-01047-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19241, KAKENHI-PROJECT-19H03156, KAKENHI-PLANNED-18H05532, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-17H06426, KAKENHI-PUBLICLY-22H05599, KAKENHI-PROJECT-23K23810
[Journal Article] UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryos2023
- Author(s)
  Uemura Shuhei、Maenohara Shoji、Inoue Kimiko、Ogonuki Narumi、Matoba Shogo、Ogura Atsuo、Kurumizaka Mayuko、Yamagata Kazuo、Sharif Jafar、Koseki Haruhiko、Ueda Koji、Unoki Motoko、Sasaki Hiroyuki
- Journal Title
  
  Life Science Alliance
  
  Volume: 6 Issue: 8 Pages: e202301904-e202301904
- DOI
  10.26508/lsa.202301904
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-23K20298
[Journal Article] Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties.2023
- Author(s)
  Das Nando D.、Chang Jen-Chien、Hon Chung-Chau、Kelly S. Thomas、Ito Shinsuke、Lizio Marina、Kaczkowski Bogumil、Watanabe Hisami、Katsushima Keisuke、Natsume Atsushi、Koseki Haruhiko、Kondo Yutaka、Minoda Aki、Umehara Takashi.
- Journal Title
  
  BMC Genomics
  
  Volume: 24 Issue: 1 Pages: 574-574
- DOI
  10.1186/s12864-023-09659-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20598, KAKENHI-PROJECT-23K05736, KAKENHI-PROJECT-20H03789, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-20H03388, KAKENHI-PROJECT-23K27438
[Journal Article] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells2023
- Author(s)
  Kumagai Jin、Kiuchi Masahiro、Kokubo Kota、Yagyu Hiroyuki、Nemoto Masahiro、Tsuji Kaori、Nagahata Ken、Sasaki Atsushi、Hishiya Takahisa、Onoue Miki、Shinmi Rie、Sonobe Yuri、Iinuma Tomohisa、Yonekura Syuji、Shinga Jun、Hanazawa Toyoyuki、Koseki Haruhiko、Nakayama Toshinori、Yokote Koutaro、Hirahara Kiyoshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 49 Pages: 2302903120-2302903120
- DOI
  10.1073/pnas.2302903120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-23K15339, KAKENHI-PROJECT-22K15484, KAKENHI-PLANNED-19H05745, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-23K27607, KAKENHI-PROJECT-19H05650
[Journal Article] Polycomb group protein BMI1 protects neuroblastoma cells against DNA damage-induced apoptotic cell death2023
- Author(s)
  Akita Nobuhiro、Okada Ryu、Mukae Kyosuke、Sugino Ryuichi P.、Takenobu Hisanori、Chikaraishi Koji、Ochiai Hidemasa、Yamaguchi Yohko、Ohira Miki、Koseki Haruhiko、Kamijo Takehiko
- Journal Title
  
  Experimental Cell Research
  
  Volume: 422 Issue: 1 Pages: 113412-113412
- DOI
  10.1016/j.yexcr.2022.113412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08269, KAKENHI-PROJECT-22K15517, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-19H03625
[Journal Article] Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis2023
- Author(s)
  Nakajima-Takagi Yaeko、Oshima Motohiko、Takano Junichiro、Koide Shuhei、Itokawa Naoki、Uemura Shun、Yamashita Masayuki、Andoh Shohei、Aoyama Kazumasa、Isshiki Yusuke、Shinoda Daisuke、Saraya Atsunori、Arai Fumio、Yamaguchi Kiyoshi、Furukawa Yoichi、Koseki Haruhiko、Ikawa Tomokatsu、Iwama Atsushi
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.83004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07806, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653
[Journal Article] SETBP1 is dispensable for normal and malignant hematopoiesis2023
- Author(s)
  Tanaka A, Nishimura K, Saika W, Kon A, Koike Y, Tatsumi H, Takeda J, Nomura M, Zang W, Nakayama M, Matsuda M, Yamazaki H, Fukumoto M, Ito H, Hayashi Y, Kitamura T, Kawamoto H, Takaori-Kondo A, Koseki H, Ogawa S
- Journal Title
  
  Leukemia
  
  Volume: 37 Issue: 9 Pages: 1802-1811
- DOI
  10.1038/s41375-023-01970-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08394, KAKENHI-PLANNED-19H05745
[Journal Article] PRC1 suppresses a female gene regulatory network to ensure testicular differentiation2023
- Author(s)
  Maezawa So、Yukawa Masashi、Hasegawa Kazuteru、Sugiyama Ryo、Iizuka Mizuho、Hu Mengwen、Sakashita Akihiko、Vidal Miguel、Koseki Haruhiko、Barski Artem、DeFalco Tony、Namekawa Satoshi H.
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 8
- DOI
  10.1038/s41419-023-05996-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18084, KAKENHI-PLANNED-19H05745, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-21H02383
[Journal Article] Genetic, Genomic, and Imaging Approaches to Dissect the Role of Polycomb Group Epigenetic Regulators in Mice2022
- Author(s)
  Yakushiji-Kaminatsui Nayuta、Kondo Takashi、Ohinata Yasuhide、Takano Junichiro、Koseki Haruhiko
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: - Pages: 207-228
- DOI
  10.1007/978-1-0716-2481-4_10
- ISBN
  9781071624807, 9781071624814
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09784, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05757
[Journal Article] Mechanisms That Influence Chromatin-Mediated Enhancer Promoter Interactions and Transcriptional Regulation2022
- Author(s)
  Shinsuke Ito, Nando Dulal Das, Takashi Umehara, and Haruhiko Koseki
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 21 Pages: 5404-5404
- DOI
  10.3390/cancers14215404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06028, KAKENHI-PLANNED-19H05745
[Journal Article] Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis2022
- Author(s)
  Kanki Yasuharu、Muramatsu Masashi、Miyamura Yuri、Kikuchi Kenta、Higashijima Yoshiki、Nakaki Ryo、Suehiro Jun-ichi、Sasaki Yuji、Kubota Yoshiaki、Koseki Haruhiko、Morioka Hiroshi、Kodama Tatsuhiko、Nakao Mitsuyoshi、Kurotaki Daisuke、Aburatani Hiroyuki、Minami Takashi
- Journal Title
  
  Cell Reports
  
  Volume: 38 Issue: 6 Pages: 110332-110332
- DOI
  10.1016/j.celrep.2022.110332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0026, KAKENHI-PLANNED-19H05744, KAKENHI-PROJECT-19H01031, KAKENHI-PROJECT-20H03432, KAKENHI-PROJECT-21H02686, KAKENHI-PROJECT-20KK0185, KAKENHI-PROJECT-21H02917, KAKENHI-PLANNED-19H05745
[Journal Article] Establishment of mouse stem cells that can recapitulate the developmental potential of primitive endoderm2022
- Author(s)
  Ohinata Yasuhide、Endo Takaho A.、Sugishita Hiroki、Watanabe Takashi、Iizuka Yusuke、Kawamoto Yurie、Saraya Atsunori、Kumon Mami、Koseki Yoko、Kondo Takashi、Ohara Osamu、Koseki Haruhiko
- Journal Title
  
  Science
  
  Volume: 375 Issue: 6580 Pages: 574-578
- DOI
  10.1126/science.aay3325
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-20K20375, KAKENHI-PLANNED-19H05745
[Journal Article] PRC1-mediated epigenetic programming is required to generate the ovarian reserve2022
- Author(s)
  Hu Mengwen、Yeh Yu-Han、Munakata Yasuhisa、Abe Hironori、Sakashita Akihiko、Maezawa So、Vidal Miguel、Koseki Haruhiko、Hunter Neil、Schultz Richard M.、Namekawa Satoshi H.
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41467-022-31759-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02383, KAKENHI-PROJECT-21K15108, KAKENHI-PLANNED-19H05745, KAKENHI-PUBLICLY-21H00233, KAKENHI-PUBLICLY-22H04700
[Journal Article] PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment2022
- Author(s)
  Takano J, Ito S, Dong Y, Sharif J, Nakajima-Takagi Y, Umeyama T, Han YW, Isono K, Kondo T, Iizuka Y, Miyai T, Koseki Y, Ikegaya M, Sakihara M, Nakayama M, Ohara O, Hasegawa Y, Hashimoto K, Arner E, Klose RJ, Iwama A, Koseki H, Ikawa T
- Journal Title
  
  Nat Commun.
  
  Volume: 13 (1) Issue: 1 Pages: 7159-7159
- DOI
  10.1038/s41467-022-34856-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06129, KAKENHI-PROJECT-21K16257, KAKENHI-PROJECT-19H05653, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746
[Journal Article] The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation2021
- Author(s)
  Kiuchi Masahiro、Onodera Atsushi、Kokubo Kota、Ichikawa Tomomi、Morimoto Yuki、Kawakami Eiryo、Takayama Naoya、Eto Koji、Koseki Haruhiko、Hirahara Kiyoshi、Nakayama Toshinori
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 218 Issue: 4 Pages: 3-8
- DOI
  10.1084/jem.20201690
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-18K07164, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-21K20754
[Journal Article] Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis2021
- Author(s)
  Shinoda Daisuke、Nakajima-Takagi Yaeko、Oshima Motohiko、Koide Shuhei、Aoyama Kazumasa、Saraya Atsunori、Harada Hironori、Rahmutulla Bahityar、Kaneda Atsushi、Yamaguchi Kiyoshi、Furukawa Yoichi、Koseki Haruhiko、Shimoda Kazuya、Tanaka Tomoaki、Sashida Goro、Iwama Atsushi
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 2 Pages: 452-463
- DOI
  10.1038/s41375-021-01402-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K21625, KAKENHI-PROJECT-20K17370, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-19H03708, KAKENHI-PROJECT-20H03713, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-21K19398, KAKENHI-PROJECT-19H04355, KAKENHI-PROJECT-20K07563
[Journal Article] Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing2021
- Author(s)
  Mochizuki K, Sharif J, Shirane K, Uranishi K, Bogutz AB, Janssen SM, Suzuki A, Okuda A, Koseki H, Lorincz MC.
- Journal Title
  
  Nature Communications
  
  Volume: 12(1) Issue: 1 Pages: 7020-7020
- DOI
  10.1038/s41467-021-27345-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16147, KAKENHI-PROJECT-17KK0185, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-19H03426, KAKENHI-PROJECT-21K06843
[Journal Article] H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos2021
- Author(s)
  Mei Hailiang、Kozuka Chisayo、Hayashi Ryoya、Kumon Mami、Koseki Haruhiko、Inoue Azusa
- Journal Title
  
  Nature Genetics
  
  Volume: 53 Issue: 4 Pages: 539-550
- DOI
  10.1038/s41588-021-00820-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05754, KAKENHI-PROJECT-18H02359, KAKENHI-PROJECT-20J21541, KAKENHI-PROJECT-19K17971, KAKENHI-PLANNED-19H05745, KAKENHI-ORGANIZER-19H05749
[Journal Article] MORC3, a novel MIWI2 association partner, as an epigenetic regulator of piRNA dependent transposon silencing in male germ cells2021
- Author(s)
  Kojima-Kita Kanako、Kuramochi-Miyagawa Satomi、Nakayama Manabu、Miyata Haruhiko、Jacobsen Steven E.、Ikawa Masahito、Koseki Haruhiko、Nakano Toru
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 20472-20490
- DOI
  10.1038/s41598-021-98940-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-19H03421, KAKENHI-PROJECT-19K16141, KAKENHI-PROJECT-16H06279
[Journal Article] UV-induced reduction in Polycomb repression promotes epidermal pigmentation2021
- Author(s)
  Li Meng-Yen、Flora Pooja、Pu Hong、Bar Carmit、Silva Jose、Cohen Idan、Galbo Phillip M.、Liu Hequn、Yu Xufen、Jin Jian、Koseki Haruhiko、D’Orazio John A.、Zheng Deyou、Ezhkova Elena
- Journal Title
  
  Developmental Cell
  
  Volume: 56 Issue: 18 Pages: 2547-2561.e8
- DOI
  10.1016/j.devcel.2021.08.006
- Data Source
  KAKENHI-PLANNED-19H05745
[Journal Article] Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation2021
- Author(s)
  Ito Y, Sasaki T, Li Y, et al
- Journal Title
  
  Cell Reports
  
  Volume: 35 Issue: 4 Pages: 109052-109052
- DOI
  10.1016/j.celrep.2021.109052
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-20H05627, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-20H00495, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21K08308
[Journal Article] Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes2021
- Author(s)
  Sugishita Hiroki、Kondo Takashi、Ito Shinsuke、Nakayama Manabu、Yakushiji-Kaminatsui Nayuta、Kawakami Eiryo、Koseki Yoko、Ohinata Yasuhide、Sharif Jafar、Harachi Mio、Blackledge Neil P.、Klose Robert J.、Koseki Haruhiko
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 5341-5341
- DOI
  10.1038/s41467-021-24894-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06621, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-21K09784, KAKENHI-PROJECT-20K20375
[Journal Article] Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing2021
- Author(s)
  Takada Yuki、Yaman-Deveci Ruken、Shirakawa Takayuki、Sharif Jafar、Tomizawa Shin-ichi、Miura Fumihito、Ito Takashi、Ono Michio、Nakajima Kuniko、Koseki Yoko、Shiotani Fuyuko、Ishiguro Kei-ichiro、Ohbo Kazuyuki、Koseki Haruhiko
- Journal Title
  
  Development
  
  Volume: 148 Issue: 10
- DOI
  10.1242/dev.194605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06642, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-19K07250, KAKENHI-PROJECT-19KK0183, KAKENHI-PUBLICLY-20H05370
[Journal Article] Tet DNA demethylase is required for plasma cell differentiation by controlling expression levels of IRF42020
- Author(s)
  Fujii, K. Tanaka, S. Hasegawa, T. Narazaki, M. Kumanogoh, A. Koseki, H. Kurosaki, T. Ise, W.
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 10 Pages: 683-690
- DOI
  10.1093/intimm/dxaa042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08883, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-17K10002, KAKENHI-PROJECT-20H03503
[Journal Article] CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats2020
- Author(s)
  Unoki Motoko、Sharif Jafar、Saito Yuichiro、Velasco Guillaume、Francastel Claire、Koseki Haruhiko、Sasaki Hiroyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 17865-17865
- DOI
  10.1038/s41598-020-74636-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05740, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-18K06961
[Journal Article] Effects of BMP7 produced by group 2 innate lymphoid cells on adipogenesis2020
- Author(s)
  Miyajima Yurina、Ealey Kafi N、Motomura Yasutaka、Mochizuki Miho、Takeno Natsuki、Yanagita Motoko、Economides Aris N、Nakayama Manabu、Koseki Haruhiko、Moro Kazuyo
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 6 Pages: 407-419
- DOI
  10.1093/intimm/dxaa013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622
[Journal Article] Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status.2020
- Author(s)
  Shrestha R, Sakata-Yanagimoto M, Maie K, Oshima M, Ishihara M, Suehara Y, Fukumoto K,1 Nakajima-Takagi Y, Matsui H, Kato T, Muto H, Sakamoto T, Kusakabe M, Nannya Y, Makishima H, Ueno H, Saiki R, Ogawa S, Chiba K, Shiraishi Y, Miyano S, Mouly E, Bernard OA, Inaba T, Koseki H, Iwama A, Chiba S
- Journal Title
  
  Blood Adv.
  
  Volume: 4(5) Issue: 5 Pages: 845-854
- DOI
  10.1182/bloodadvances.2019001324
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08334, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H01053, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-18K16076, KAKENHI-PROJECT-20K08725, KAKENHI-PROJECT-19K23879, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-19H03684
[Journal Article] Pivotal role of CD103 in the development of psoriasiform dermatitis2020
- Author(s)
  Fukui Takehito、Fukaya Tomohiro、Uto Tomofumi、Takagi Hideaki、Nasu Junta、Miyanaga Noriaki、Nishikawa Yotaro、Koseki Haruhiko、Choijookhuu Narantsog、Hishikawa Yoshitaka、Yamashita Yoshihiro、Sato Katsuaki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-020-65355-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-18K15194, KAKENHI-PROJECT-19K16477
[Journal Article] The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon.2020
- Author(s)
  Hikaru Eto#, Yusuke Kishi#*, Nayuta Yakushiji-Kaminatsu, Hiroki Sugishita, Shun Utsunomiya, Haruhiko Koseki, and Yukiko Gotoh* (#Equal contribution, *Correspondence)
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 5709-5709
- DOI
  10.1038/s41467-020-19556-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05253, KAKENHI-PLANNED-19H05745, KAKENHI-PUBLICLY-20H05383, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-20J14522, KAKENHI-PROJECT-19K22695, KAKENHI-PROJECT-18K14622, KAKENHI-PROJECT-16H06279, KAKENHI-PLANNED-16H06481
[Journal Article] Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity2020
- Author(s)
  Tanaka, S. Ise, W. Inoue, T. Ito, A. Ono, C. Shima, Y. Sakakibara, S. Nakayama, M. Fujii, K. Miura, I. Sharif, J. Koseki, H. Koni, P. A. Raman, I. Li, Q. Z. Kubo, M. Fujiki, K. Nakato, R. Shirahige, K. Araki, H. Miura, F. Ito, T. Kawakami, E. Baba, Y. Kurosaki, T.
- Journal Title
  
  Nature Immunology
  
  Volume: 21 Issue: 8 Pages: 950-961
- DOI
  10.1038/s41590-020-0700-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08883, KAKENHI-PROJECT-20K21384, KAKENHI-PLANNED-17H06331, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-18H02626, KAKENHI-PROJECT-19H03491, KAKENHI-PROJECT-19K22537, KAKENHI-PROJECT-20H03503
[Journal Article] Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population.2020
- Author(s)
  Toshimori K, Fukuda S, et al.
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 19933-19933
- DOI
  10.1038/s41598-020-77105-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11521, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-18H02724
[Journal Article] Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression2019
- Author(s)
  Bae Joonbeom、Choi Sang-Pil、Isono Kyoichi、Lee Ji Yoon、Park Si-Won、Choi Chang-Yong、Han Jihye、Kim Sang-Hoon、Lee Han-Hyoung、Park Kyungmin、Jin Hyun Yong、Lee Suk Jun、Park Chung-Gyu、Koseki Haruhiko、Lee Young Sik、Chun Taehoon
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1
- DOI
  10.1038/s41467-019-11386-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622
[Journal Article] Chromatin and epigenetics in development: a Special Issue2019
- Author(s)
  Bruneau Benoit G.、Koseki Haruhiko、Strome Susan、Torres-Padilla Maria-Elena
- Journal Title
  
  Development
  
  Volume: 146 Issue: 19 Pages: 185025-185025
- DOI
  10.1242/dev.185025
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745
[Journal Article] PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation2019
- Author(s)
  Healy Evan、Mucha Marlena、Glancy Eleanor、Fitzpatrick Darren J.、Conway Eric、Neikes Hannah K.、Monger Craig、Van Mierlo Guido、Baltissen Marijke P.、Koseki Yoko、Vermeulen Michiel、Koseki Haruhiko、Bracken Adrian P.
- Journal Title
  
  Molecular Cell
  
  Volume: 76 Issue: 3 Pages: 437-452.e6
- DOI
  10.1016/j.molcel.2019.08.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622
[Journal Article] Human gain-of-function STAT1 mutation disturbs IL-17 immunity in mice2019
- Author(s)
  Tamaura Moe、Satoh-Takayama Naoko、Tsumura Miyuki、Sasaki Takaharu、Goda Satoshi、Kageyama Tomoko、Hayakawa Seiichi、Kimura Shunsuke、Asano Takaki、Nakayama Manabu、Koseki Haruhiko、Ohara Osamu、Okada Satoshi、Ohno Hiroshi、Kobayashi Masao
- Journal Title
  
  International Immunology
  
  Volume: － Issue: 4 Pages: 259-272
- DOI
  10.1093/intimm/dxz079
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0228, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-17K10112, KAKENHI-PROJECT-20K08158, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-18K07189, KAKENHI-PROJECT-18K07847
[Journal Article] KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity2019
- Author(s)
  Turberfield Anne H、Kondo Takashi、Nakayama Manabu、Koseki Yoko、King Hamish W、Koseki Haruhiko、Klose Robert J
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 47 Issue: 17 Pages: 9005-9023
- DOI
  10.1093/nar/gkz607
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622
[Journal Article] Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression2019
- Author(s)
  Bar Carmit、Cohen Idan、Zhao Dejian、Pothula Venu、Litskevitch Anna、Koseki Haruhiko、Zheng Deyou、Ezhkova Elena
- Journal Title
  
  Cell Reports
  
  Volume: 28 Issue: 1 Pages: 257-266.e5
- DOI
  10.1016/j.celrep.2019.06.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622
[Journal Article] Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression2019
- Author(s)
  Fursova NA, Blackledge NP, Nakayama M, Ito S, Koseki Y, Farcas AM, King HW, Koseki H, Klose RJ.
- Journal Title
  
  Molecular Cell
  
  Volume: 印刷中 Issue: 5 Pages: 1020-1036
- DOI
  10.1016/j.molcel.2019.03.024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05602, KAKENHI-PROJECT-19K06621, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622
[Journal Article] KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.2019
- Author(s)
  Isshiki Y, Nakajima-Takagi Y, Oshima M, Aoyama K, Rizk M, Kurosawa S, Saraya A, Kondo T, Sakaida E, Nakaseko C, Yokote K, Koseki H, Iwama A.
- Journal Title
  
  Blood Adv
  
  Volume: 3 Issue: 17 Pages: 2537-2549
- DOI
  10.1182/bloodadvances.2018028522
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08348, KAKENHI-WRAPUP-19H05442, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-18K19555
[Journal Article] Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway2018
- Author(s)
  Jansz Natasha、Nesterova Tatyana、Keniry Andrew、Iminitoff Megan、Hickey Peter F.、Pintacuda Greta、Masui Osamu、Kobelke Simon、Geoghegan Niall、Breslin Kelsey A.、Willson Tracy A.、Rogers Kelly、Kay Graham F.、Fox Archa H.、Koseki Haruhiko、Brockdorff Neil、Murphy James M.、Blewitt Marnie E.
- Journal Title
  
  Cell Reports
  
  Volume: 25 Issue: 7 Pages: 1912-1923.e9
- DOI
  10.1016/j.celrep.2018.10.044
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] Pivotal Role of IL-22 Binding Protein in the Epithelial Autoregulation of Interleukin-22 Signaling in the Control of Skin Inflammation2018
- Author(s)
  Tomohiro Fukaya, Takehito Fukui, Tomofumi Uto, Hideaki Takagi, Junta Nasu, Noriaki, Miyanaga, Keiichi Arimura, Takeshi Nakamura, Haruhiko Koseki, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 1-13
- DOI
  10.3389/fimmu.2018.01418
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15732, KAKENHI-PROJECT-18K15194, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-18H02670, KAKENHI-PROJECT-16K08471
[Journal Article] Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome.2018
- Author(s)
  Tara S, Isshiki Y, Nakajima-Takagi Y, Oshima M, Aoyama K, Tanaka T, Shinoda D, Koide S, Saraya A, Miyagi S, Manabe I, Matsui H, Koseki H, Bardwell VJ, Iwama A.
- Journal Title
  
  Blood
  
  Volume: 132(23) Issue: 23 Pages: 2470-2483
- DOI
  10.1182/blood-2018-01-827964
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08348, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16K09840, KAKENHI-INTERNATIONAL-15K21751
[Journal Article] Growing oocyte specific transcription-dependent de novo DNA methylation at the imprinted Zrsr1-DMR2018
- Author(s)
  Joh, K., Matsuhisa, F., Kitajima, S., Nishioka, K., Higashimoto, K., Yatsuki, H., Kono, T., Koseki, H., Soejima, H.
- Journal Title
  
  Epigenetics & Chromatin
  
  Volume: 11 Issue: 1 Pages: 28-28
- DOI
  10.1186/s13072-018-0200-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07138, KAKENHI-PROJECT-17K08687, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16K09970, KAKENHI-PROJECT-18H00338
[Journal Article] Ubiquitination-independent repression of PRC1 targets during neuronal fate restriction in the developing mouse neocortex2018
- Author(s)
  Masafumi Tsuboi, Yusuke Kishi, Wakana Kyozuka, Haruhiko Koseki, Yusuke Hirabayashi, and Yukiko Gotoh*
- Journal Title
  
  Developmental Cell
  
  Volume: 47 Issue: 6 Pages: 758-772
- DOI
  10.1016/j.devcel.2018.11.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14622, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-15K06947, KAKENHI-PUBLICLY-16H01297, KAKENHI-PLANNED-16H06481, KAKENHI-PROJECT-15H05773
[Journal Article] Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells2018
- Author(s)
  Haruko Shima、Emi Takamatsu-Ichihara、Mika Shino、Kazutsune Yamagata、Takuo Katsumoto、Yukiko Aikawa、Shuhei Fujita、Haruhiko Koseki、Issay Kitabayashi
- Journal Title
  
  Blood
  
  Volume: 131 Issue: 16 Pages: 1833-1845
- DOI
  10.1182/blood-2017-05-787226
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21646, KAKENHI-PROJECT-16H02622
[Journal Article] PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification2018
- Author(s)
  Cohen Idan、Zhao Dejian、Bar Carmit、Valdes Victor J.、Dauber-Decker Katherine L.、Nguyen Minh Binh、Nakayama Manabu、Rendl Michael、Bickmore Wendy A.、Koseki Haruhiko、Zheng Deyou、Ezhkova Elena
- Journal Title
  
  Cell Stem Cell
  
  Volume: 22 Issue: 5 Pages: 726-739.e7
- DOI
  10.1016/j.stem.2018.04.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment2018
- Author(s)
  Dimitrova Emilia、Kondo Takashi、Feldmann Angelika、Nakayama Manabu、Koseki Yoko、Konietzny Rebecca、Kessler Benedikt M、Koseki Haruhiko、Klose Robert J
- Journal Title
  
  eLife
  
  Volume: 7
- DOI
  10.7554/elife.37084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain2018
- Author(s)
  Murao Naoya、Matsubara Shuzo、Matsuda Taito、Noguchi Hirofumi、Mutoh Tetsuji、Mutoh Masahiro、Koseki Haruhiko、Namihira Masakazu、Nakashima Kinichi
- Journal Title
  
  Neuroscience Research
  
  Volume: in press Pages: 31-43
- DOI
  10.1016/j.neures.2018.05.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14820, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-17K15624
[Journal Article] DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell-related genes in mouse embryonic stem cells2018
- Author(s)
  Tatsumi Daiki、Hayashi Yohei、Endo Mai、Kobayashi Hisato、Yoshioka Takumi、Kiso Kohei、Kanno Shinichiro、Nakai Yuji、Maeda Ikuma、Mochizuki Kentaro、Tachibana Makoto、Koseki Haruhiko、Okuda Akihiko、Yasui Akira、Kono Tomohiro、Matsui Yasuhisa
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 11 Pages: e0205969-e0205969
- DOI
  10.1371/journal.pone.0205969
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07726, KAKENHI-ORGANIZER-17H06423, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16H05143, KAKENHI-PROJECT-18H02419, KAKENHI-PROJECT-15H05579, KAKENHI-PLANNED-17H06424, KAKENHI-PUBLICLY-18H04875
[Journal Article] Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in the mouse distal forelimb bud2018
- Author(s)
  Yakushiji-Kaminatsui Nayuta、Kondo Takashi、Hironaka Ken-ichi、Sharif Jafar、Endo Takaho A.、Nakayama Manabu、Masui Osamu、Koseki Yoko、Kondo Kaori、Ohara Osamu、Vidal Miguel、Morishita Yoshihiro、Koseki Haruhiko
- Journal Title
  
  Development
  
  Volume: 145
- DOI
  10.1242/dev.166348
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] PRC1 preserves epidermal tissue integrity independently of PRC22018
- Author(s)
  Cohen Idan、Zhao Dejian、Menon Gopinathan、Nakayama Manabu、Koseki Haruhiko、Zheng Deyou、Ezhkova Elena
- Journal Title
  
  Genes & Development
  
  Volume: 33 Issue: 1-2 Pages: 55-60
- DOI
  10.1101/gad.319939.118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.2017
- Author(s)
  Endoh M, Endo TA, Shinga J, Hayashi K, Farcas A, Ma KW, Ito S, Sharif J, Endoh T, Onaga N, Nakayama M, Ishikura T, Masui O, Kessler BM, Suda T, Ohara O, Okuda A, Klose RJ, Koseki H.
- Journal Title
  
  Elife
  
  Volume: 6 Pages: 27970-27970
- DOI
  10.7554/elife.21064
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-15H05602, KAKENHI-PROJECT-16K07372, KAKENHI-PROJECT-16K14773, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-26221309
[Journal Article] Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.2017
- Author(s)
  Choi J, Huebner AJ, Clement K, Walsh RM, Savol A, Lin K, Gu H, Di Stefano B, Brumbaugh J, Kim SY, Sharif J, Rose CM, Mohammad A, Odajima J, Charron J, Shioda T, Gnirke A, Gygi S, Koseki H, Sadreyev RI, Xiao A, Meissner A, Hochedlinger K.
- Journal Title
  
  Nature
  
  Volume: 548 Issue: 7666 Pages: 219-223
- DOI
  10.1038/nature23274
- Open Access
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies2017
- Author(s)
  Tanaka Tomoyuki、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Tara Shiro、Oshima Motohiko、Saraya Atsunori、Koide Shuhei、Si Sha、Manabe Ichiro、Sanada Masashi、Nakayama Manabu、Masuko Masayoshi、Sone Hirohito、Koseki Haruhiko、Iwama Atsushi
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 214 Issue: 10 Pages: 2901-2913
- DOI
  10.1084/jem.20170167
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09868, KAKENHI-PROJECT-17K10136, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16K15498, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] PhysiologicalSrsf2P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice2017
- Author(s)
  Kon Ayana、Yamazaki Satoshi、Nannya Yasuhito、Kataoka Keisuke、Ota Yasunori、Nakagawa Masahiro Marshall、Yoshida Kenichi、Shiozawa Yusuke、Morita Maiko、Yoshizato Tetsuichi、Sanada Masashi、Nakayama Manabu、Koseki Haruhiko、Nakauchi Hiromitsu、Ogawa Seishi
- Journal Title
  
  Blood
  
  Volume: 131 Issue: 6 Pages: 621-635
- DOI
  10.1182/blood-2017-01-762393
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-17H05086, KAKENHI-PROJECT-16K19574
[Journal Article] PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.2017
- Author(s)
  Almeida M, Pintacuda G, Masui O, Koseki Y, Gdula M, Cerase A, Brown D, Mould A, Innocent C, Nakayama M, Schermelleh L, Nesterova TB, Koseki H, Brockdorff N.
- Journal Title
  
  Science
  
  Volume: 356 Issue: 6342 Pages: 1081-1084
- DOI
  10.1126/science.aal2512
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16K14773
[Journal Article] Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses.2017
- Author(s)
  Torrente L, Sanchez C, Moreno R, Chowdhry S, Cabello P, Isono K, Koseki H, Honda T, Hayes JD, Dinkova-Kostova AT, de la Vega L.
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 44 Pages: 6204-6212
- DOI
  10.1038/onc.2017.221
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] Polycomb directs timely activation of germline genes in spermatogenesis2017
- Author(s)
  Maezawa S, Hasegawa K, Yukawa M, Sakashita A, Alavattam KG, Andreassen PR, Vidal M, Koseki H, Barski A, Namekawa SH.
- Journal Title
  
  Genes Dev
  
  Volume: 31 Issue: 16 Pages: 1693-1703
- DOI
  10.1101/gad.302000.117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice2017
- Author(s)
  Dong Yixin、Isono Kyo-ichi、Ohbo Kazuyuki、Endo Takaho A.、Ohara Osamu、Maekawa Mamiko、Toyama Yoshiro、Ito Chizuru、Toshimori Kiyotaka、Helin Kristian、Ogonuki Narumi、Inoue Kimiko、Ogura Atsuo、Yamagata Kazutsune、Kitabayashi Issay、Koseki Haruhiko
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 37 Issue: 19
- DOI
  10.1128/mcb.00082-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08156, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-15K10638
[Journal Article] CFC1 is a cancer stemness-regulating factor in neuroblastoma2017
- Author(s)
  Chikaraishi Koji、Takenobu Hisanori、Sugino Ryuichi P.、Mukae Kyosuke、Akter Jesmin、Haruta Masayuki、Kurosumi Masafumi、Endo Takaho A.、Koseki Haruhiko、Shimojo Naoki、Ohira Miki、Kamijo Takehiko
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 28 Pages: 45046-45059
- DOI
  10.18632/oncotarget.18464
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10051, KAKENHI-PROJECT-17K10131, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-17H01592, KAKENHI-PROJECT-17K19623
[Journal Article] An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells.2017
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  Berrens RV, Andrews S, Spensberger D, Santos F, Dean W, Gould P, Sharif J, Olova N, Chandra T, Koseki H, von Meyenn F, Reik W.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 21 Issue: 5 Pages: 694-703
- DOI
  10.1016/j.stem.2017.10.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.2017
- Author(s)
  Graf U, Casanova EA, Wyck S, Dalcher D, Gatti M, Vollenweider E, Okoniewski MJ, Weber FA, Patel SS, Schmid MW, Li J, Sharif J, Wanner GA, Koseki H, Wong J, Pelczar P, Penengo L, Santoro R, Cinelli P.
- Journal Title
  
  Nat Cell Biol
  
  Volume: 19 Issue: 7 Pages: 763-773
- DOI
  10.1038/ncb3554
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin.2017
- Author(s)
  Brown DA, Di Cerbo V, Feldmann A, Ahn J, Ito S, Blackledge NP, Nakayama M, McClellan M, Dimitrova E, Turberfield AH, Long HK, King HW, Kriaucionis S, Schermelleh L, Kutateladze T, Koseki H, Klose RJ.
- Journal Title
  
  Cell Rep
  
  Volume: 20 Issue: 10 Pages: 2313-2327
- DOI
  10.1016/j.celrep.2017.08.030
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-15H05602
[Journal Article] Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos.2017
- Author(s)
  Maenohara S, Unoki M, Toh H, Ohishi H, Sharif, J, Koseki, H, Sasaki H.
- Journal Title
  
  PLoS Genet
  
  Volume: 13 Issue: 10 Pages: e1007042-e1007042
- DOI
  10.1371/journal.pgen.1007042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112010, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-15K06803
[Journal Article] No Winter Lasts Forever: Polycomb Complexes Convert Epigenetic Memory of Cold into Flowering2017
- Author(s)
  Sharif J, Koseki H.
- Journal Title
  
  Dev Cell
  
  Volume: 42 Issue: 6 Pages: 563-564
- DOI
  10.1016/j.devcel.2017.09.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways2017
- Author(s)
  Jullien J, Vodnala M, Pasque V, Oikawa M, Miyamoto K, Allen G, David SA, Brochard V, Wang S, Bradshaw C, Koseki H, Sartorelli V, Beaujean N, Gurdon　J
- Journal Title
  
  Molecular Cell
  
  Volume: 65 Issue: 5 Pages: 873-884
- DOI
  10.1016/j.molcel.2017.01.030
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01321, KAKENHI-PROJECT-16H02622, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-16H01222, KAKENHI-INTERNATIONAL-15K21737
[Journal Article] Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.2016
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  Grijzenhout A, Godwin J, Koseki H, Gdula MR, Szumska D, McGouran JF, Bhattacharya S, Kessler BM, Brockdorff N, Cooper S
- Journal Title
  
  Development
  
  Volume: 143 Issue: 15 Pages: 2716-2723
- DOI
  10.1242/dev.123935
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Journal Article] RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression2016
- Author(s)
  Yakushiji-Kaminatsui, N., Kondo, T., Endo, T.A., Koseki, Y., Kondo, K., Ohara, O., Vidal, M. and Koseki, H.
- Journal Title
  
  Development
  
  Volume: 143 Pages: 276-285
- DOI
  10.1242/dev.127506
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15076, KAKENHI-PROJECT-23249015
[Journal Article] Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program.2016
- Author(s)
  Ikawa T, Masuda K, Endo TA, Endo M, Isono K, Koseki Y, Nakagawa R, Kometani K, Takano J, Agata Y, Katsura Y, Kurosaki T, Vidal M, Koseki H, Kawamoto H.
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  Genes. Dev.
  
  Volume: 30 Issue: 22 Pages: 2475-2485
- DOI
  10.1101/gad.290593.116
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-15H04743, KAKENHI-PROJECT-26670136, KAKENHI-PROJECT-16K07372, KAKENHI-PROJECT-16K09870, KAKENHI-PROJECT-16K15289, KAKENHI-PROJECT-16K15215
[Journal Article] Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells2016
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  Si S, Nakajima-Takagi Y, Aoyama K, Oshima M, Saraya A, Sugishita H, Nakayama M, Ishikura T, Koseki H, Iwama A
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 5 Pages: e0154561-e0154561
- DOI
  10.1371/journal.pone.0154561
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-14J40042, KAKENHI-PROJECT-15K19544, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells.2016
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  Tsuchiya Y, Naito T, Tenno M, Maruyama M, Koseki H, Taniuchi I, Naoe Y.
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  J Leukoc Biol.
  
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- DOI
  10.1189/jlb.1a0915-396rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26114720, KAKENHI-PROJECT-26293109, KAKENHI-PROJECT-16H02622
[Journal Article] De novo DNA methylation drives 5hmC accumulation in mouse zygotes.2016
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  Amouroux R, Nashun B, Shirane K, Nakagawa S, Hill PW, D'Souza Z, Nakayama M, Matsuda M, Turp A, Ndjetehe E, Encheva V, Kudo NR, Koseki H, Sasaki H, Hajkova P.
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  Nat. Cell Biol.
  
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  10.1038/ncb3296
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21737, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112010, KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-14J04310
[Journal Article] Activation of Endogenous Retroviruses in Dnmt1-/- ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.2016
- Author(s)
  Sharif J, Endo TA, Nakayama M, Karimi MM, Shimada M, Katsuyama K, Goyal P, Brind'Amour J, Sun MA, Sun Z, Ishikura T, Mizutani-Koseki Y, Ohara O, Shinkai Y, Nakanishi M, Xie H, Lorincz MC, Koseki H.
- Journal Title
  
  Cell Stem Cell
  
  Volume: Epub ahead of print Issue: 1 Pages: 999-999
- DOI
  10.1016/j.stem.2016.03.013
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870847, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-15K08280, KAKENHI-PROJECT-16K15239, KAKENHI-PROJECT-26250027
[Journal Article] Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.2016
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  Aihara H
- Journal Title
  
  Mol. Cell.
  
  Volume: 64 Issue: 1 Pages: 176-188
- DOI
  10.1016/j.molcel.2016.09.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01307, KAKENHI-PLANNED-24118003, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-26281020, KAKENHI-PROJECT-15K12203, KAKENHI-PROJECT-15K15353, KAKENHI-PROJECT-16K07201, KAKENHI-PROJECT-15K15581, KAKENHI-PROJECT-16K19040
[Journal Article] Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity2015
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  Chiacchiera F, Rossi A, Jammula S, Piunti A, Scelfo A, Ordóñez-Morán P, Huelsken J, Koseki H, Pasini D
- Journal Title
  
  Cell Stem Cell
  
  Volume: 18 Issue: 1 Pages: 91-103
- DOI
  10.1016/j.stem.2015.09.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249015
[Journal Article] Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome2015
- Author(s)
  Schoenfelder S, Sugar R, Dimond A, Javierre BM, Armstrong H, Mifsud B, Dimitrova E, Matheson L, Tavares-Cadete F, Furlan-Magaril M, Segonds-Pichon A, Jurkowski W, Wingett SW, Tabbada K, Andrews S, Herman B, LeProust E, Osborne CS, Koseki H, Fraser P, Luscombe NM, Elderkin S
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  Nat Genet.
  
  Volume: 47 Issue: 10 Pages: 1179-86
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  10.1038/ng.3393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249015
[Journal Article] Nuclear transcriptome profiling of induced pluripotent stem cells and embryonic stem cells identify non-coding loci resistant to reprogramming2015
- Author(s)
  Fort A, Yamada D, Hashimoto K, Koseki H, Carninci P
- Journal Title
  
  Cell Cycle
  
  Volume: 14 Issue: 8 Pages: 1148-55
- DOI
  10.4161/15384101.2014.988031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249015
[Journal Article] Generating a transgenic mouse line stably expressing human MHC surface antigen from a HAC carrying multiple genomic BACs.2015
- Author(s)
  Hasegawa Y, Ishikura T, Hasegawa T, Watanabe T, Suzuki J, Nakayama M, Okamura Y, Okazaki T, Koseki H, Ohara O, Ikeno M, and Masumoto H
- Journal Title
  
  Chromosoma
  
  Volume: 124(1) Issue: 1 Pages: 107-118
- DOI
  10.1007/s00412-014-0488-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23114008, KAKENHI-PROJECT-24310143
[Journal Article] Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment2014
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  Cooper S, Dienstbier M, Hassan R, Schermelleh L, Sharif J, Blackledge NP, De Marco V, Elderkin S, Koseki H, Klose R, Heger A, Brockdorff N
- Journal Title
  
  Cell Reports
  
  Volume: 7 Issue: 5 Pages: 1456-70
- DOI
  10.1016/j.celrep.2014.04.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249015
[Journal Article] The epigenetic regulator Uhrf1 facilitates proliferation and maturation of colonic regulatory T cells2014
- Author(s)
  Yuuki Obata*, Yukihiro Furusawa*, Takaho A. Endo, Jafar Sharif, Daisuke Takahashi, Koji Atarashi, Manabu Nakayama, Satoshi Onawa, Yumiko Fujimura, Masumi Takahashi, Tomokatsu Ikawa, Takeshi Otsubo, Yuki I. Kawamura, Taeko Dohi, Shoji Tajima, Osamu Ohara, Kenya Honda, Shohei Hori, Hiroshi Ohno, Haruhiko Koseki and Koji Hase. 【* : 筆頭筆者】
- Journal Title
  
  Nature Immunology
  
  Volume: 15 Issue: 6 Pages: 571-579
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  10.1038/ni.2886
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J02667, KAKENHI-PLANNED-23114008, KAKENHI-PROJECT-23247030, KAKENHI-PROJECT-23249015, KAKENHI-PUBLICLY-24117723, KAKENHI-PROJECT-24689042, KAKENHI-PROJECT-24890293, KAKENHI-PUBLICLY-25118732, KAKENHI-PUBLICLY-25118733, KAKENHI-PROJECT-25291025, KAKENHI-PROJECT-25293114, KAKENHI-PROJECT-25460965, KAKENHI-PUBLICLY-26116709, KAKENHI-PROJECT-26293229, KAKENHI-PROJECT-26670472
[Journal Article] Stem cell epigenetics: looking forward2014
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  Benitah SA, Bracken A, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL
- Journal Title
  
  Cell Stem Cell
  
  Volume: 14 Issue: 6 Pages: 706-9
- DOI
  10.1016/j.stem.2014.05.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249015
[Journal Article] Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation2014
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  Blackledge NP, Farcas AM, Kondo T, King HW, McGouran JF, Hanssen LL, Ito S, Cooper S, Kondo K, Koseki Y, Ishikura T, Long HK, Sheahan TW, Brockdorff N, Kessler BM, Koseki H, Klose RJ
- Journal Title
  
  Cell
  
  Volume: 157 Issue: 6 Pages: 1445-59
- DOI
  10.1016/j.cell.2014.05.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249015
[Journal Article] Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia.2014
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  Matsunawa M, Yoshida K
- Journal Title
  
  Leukemia
  
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- DOI
  10.1038/leu.2014.73
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J04216, KAKENHI-PLANNED-22134006, KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-23249052, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24390242, KAKENHI-PROJECT-24659458, KAKENHI-PROJECT-25670152, KAKENHI-PROJECT-25670446, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-26640075, KAKENHI-PROJECT-26890016
[Journal Article] Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance2014
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  Fort A, Hashimoto K, Yamada D, Salimullah M, Keya CA, Saxena A, Bonetti A, Voineagu I, Bertin N, Kratz A, Noro Y, Wong CH, de Hoon M, Andersson R, Sandelin A, Suzuki H, Wei CL, Koseki H; FANTOM Consortium, Hasegawa Y, Forrest AR, Carninci P
- Journal Title
  
  Nature Genetics
  
  Volume: 46 Issue: 6 Pages: 558-66
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  10.1038/ng.2965
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249015
[Journal Article] The Polycomb Potentiates Meis2 Activation in Midbrain by Mediating Interaction of the Promoter with a Tissue-Specific Enhancer.2014
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  Kondo T., Isono K, Kondo K, Endo TA, Itohara S, Vidal M, and Koseki H.
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  Dev Cell.
  
  Volume: 28 Issue: 1 Pages: 94-101
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  10.1016/j.devcel.2013.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249015
[Journal Article] Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.2013
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  Nishimura T, Koseki H, Nakauchi H.　他
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  Cell Stem Cell.
  
  Volume: 12 Issue: 1 Pages: 114-26
- DOI
  10.1016/j.stem.2012.11.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23591413, KAKENHI-PROJECT-23592022, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24390257, KAKENHI-PLANNED-23106004
[Journal Article] A novel de novo point mutation of OCT-binding site in the IGF2/H19-imprinting control region in a patient with Beckwith-Wiedemann syndrome.2013
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  Higashimoto K, Jozaki K, Kosho T, Matsubara K, Sato T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, SoejimaH*
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  Clin Genet
  
  Volume: in press Issue: 6 Pages: 539-544
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  10.1111/cge.12318
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22132004, KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23659181, KAKENHI-PROJECT-25253023, KAKENHI-PROJECT-25461554, KAKENHI-PROJECT-25461648, KAKENHI-PROJECT-25860898, KAKENHI-PROJECT-26670169
[Journal Article] Repression of the transcription factor Bach2 contributes to predisposition of IgG1 memory B cells toward plasma cell differentiation.2013
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  Kometani K, Nakagawa R, Shinnakasu R, Kaji T, Rybouchkin A, Moriyama S, Furukawa K, Koseki H, Takemori T, Kurosaki T.
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  Immunity.
  
  Volume: 39 Issue: 1 Pages: 136-47
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  10.1016/j.immuni.2013.06.011
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- Data Source
  KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-24790487
[Journal Article] Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication2013
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  Nishiyama, A
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  Nature
  
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  10.1038/nature12488
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118003, KAKENHI-PROJECT-23240124, KAKENHI-PROJECT-23249015, KAKENHI-PUBLICLY-24113711, KAKENHI-PROJECT-24659137, KAKENHI-PROJECT-24790290, KAKENHI-PUBLICLY-25131717, KAKENHI-PROJECT-25461659
[Journal Article] An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity2013
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  Shirakawa, T., Yaman-Deveci, R., Tomizawa, S., Kamizato, Y., Nakajima, K., Sone, H., Sato, Y., Sharif, J., Yamashita, A., Takada-Horisawa, Y., Yoshida, S., Ura, K., Muto, M., Koseki, H., Suda, T., and Ohbo, K.
- Journal Title
  
  Development
  
  Volume: 140 Issue: 17 Pages: 3565-3576
- DOI
  10.1242/dev.094045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11J09354, KAKENHI-PLANNED-20116004, KAKENHI-PLANNED-21115004, KAKENHI-PLANNED-22131003, KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23687025, KAKENHI-PROJECT-24247041, KAKENHI-PLANNED-25114004, KAKENHI-PROJECT-25670097
[Journal Article] Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.2013
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  Zhu Y, Li Y, Haraguchi S, Yu M, Ohira M, Ozaki T, Nakagawa A, Ushijima T, Isogai E, Koseki H, Nakamura Y, Kong C, Mehlen P, Arakawa H, Nakagawara A.
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  J Clin Invest.
  
  Volume: 123 Issue: 7 Pages: 2935-47
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  10.1172/jci65988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23501278, KAKENHI-PROJECT-23591562, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24591566, KAKENHI-PROJECT-24592703, KAKENHI-PROJECT-25670169
[Journal Article] Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells2013
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  Vizcardo, R
- Journal Title
  
  Cell Stem Cell
  
  Volume: 12 Issue: 1 Pages: 31-36
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  10.1016/j.stem.2012.12.006
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22118001, KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23380186, KAKENHI-PROJECT-24249057, KAKENHI-PROJECT-24689042, KAKENHI-PROJECT-24790486, KAKENHI-PLANNED-22118004
[Journal Article] SAM Domain Polymerization Links Subnuclear Clustering of PRC1 to Gene Silencing.2013
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  Dev Cell.
  
  Volume: 26 Issue: 6 Pages: 565-577
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  10.1016/j.devcel.2013.08.016
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- Data Source
  KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-25670152
[Journal Article] Role of SOX17 in hematopoietic development from human embryonic stem cells.2013
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  Blood.
  
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  10.1182/blood-2012-05-431403
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- Data Source
  KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791071, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24591381, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-23130502, KAKENHI-PUBLICLY-24116711
[Journal Article] CCN3 protein participates in bone regeneration as an inhibitory factor.2013
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  The Journal of Biological Chemistry
  
  Volume: 288 Issue: 27 Pages: 19973-19985
- DOI
  10.1074/jbc.m113.454652
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- Data Source
  KAKENHI-PROJECT-21390428, KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23592696, KAKENHI-PROJECT-25253098, KAKENHI-PROJECT-25462915, KAKENHI-PROJECT-25670170
[Journal Article] UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9.2013
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  Liu X, Gao Q, Li P, Zhao Q, Zhang J, Li J, Koseki H, Wong J.
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  Nat Commun.
  
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  10.1038/ncomms2562
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- Data Source
  KAKENHI-PROJECT-23249015
[Journal Article] WIP1, a homeostatic regulator of the DNA damage response, is targeted by HIPK2 for phosphorylation and degradation.2013
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  Choi DW, Na W, Kabir MH, Yi E, Kwon S, Yeom J, Ahn JW, Choi HH, Lee Y, Seo KW, Shin MK, Park SH, Yoo HY, Isono K, Koseki H, Kim ST, Lee C, Kwon YK, Choi CY.
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  Mol Cell.
  
  Volume: 51 Issue: 3 Pages: 374-85
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  10.1016/j.molcel.2013.06.010
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- Data Source
  KAKENHI-PROJECT-23249015
[Journal Article] KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.2012
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  elife
  
  Volume: 1
- DOI
  10.7554/elife.00205
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014, KAKENHI-PROJECT-23249015
[Journal Article] RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells.2012
- Author(s)
  Hisada K, Sanchez C, Endo TA, Endoh M, Roman-Trufero M, Sharif J, Koseki H, Vidal M.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 32 Pages: 1139-49
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] RYBP represses endogenous retroviruses, preimplantation-and germline-specific genes in mouse embryonic stem cells2012
- Author(s)
  Hisada K, Sanchez C, Endo T, Endoh M, Roman-Trufero M, Sharif J, Koseki H, Vidal M
- Journal Title
  
  Mol Cell Biol
  
  Volume: 32 Pages: 1139-1149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602006
[Journal Article] Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity.2012
- Author(s)
  Endoh M, Endo TA, Endoh T, Isono K, Sharif J, Ohara O, Toyoda T, Ito T, Eskeland R, Bickmore WA, Vidal M, Bernstein BE, Koseki H.
- Journal Title
  
  PLoS Genet.
  
  Volume: 8 Issue: 7 Pages: e1002774-e1002774
- DOI
  10.1371/journal.pgen.1002774
- NAID
  120006985569
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014, KAKENHI-PROJECT-22590278, KAKENHI-PUBLICLY-23131510, KAKENHI-PROJECT-23249015, KAKENHI-PLANNED-24118003, KAKENHI-PUBLICLY-24116711, KAKENHI-ORGANIZER-24118001
[Journal Article] H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions.2012
- Author(s)
  Ku M, Jaffe JD, Koche RP, Rheinbay E, Endoh M, Koseki H, Carr SA, Bernstein BE.
- Journal Title
  
  Genome Biol.
  
  Volume: 13
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] Is there a role for endogenous retroviruses to mediate long-term adaptive phenotypic response upon environmental inputs?2012
- Author(s)
  Sharif J
- Journal Title
  
  Philos Trans R Soc Lond B Biol Sci.
  
  Volume: 368 Issue: 1609 Pages: 20110340-20110340
- DOI
  10.1098/rstb.2011.0340
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014, KAKENHI-PROJECT-23249015
[Journal Article] HP1γ links histone methylation marks to meiotic synapsis in mice.2011
- Author(s)
  Takada Y, Naruse C, Costa Y, Shirakawa T, Tachibana M, Sharif J, Kezuka-Shiotani F, Kakiuchi D, Masumoto H, Shinkai Y, Ohbo K, Peters AH, Turner JM, Asano M, Koseki H.
- Journal Title
  
  Development
  
  Volume: 138 Pages: 4207-17
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] Mammalian Polycomblike Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate Polycomb activity at both the Hox gene cluster and at Cdkn2a genes.2011
- Author(s)
  Li X, Isono KI, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N, Koseki H.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 31 Pages: 351-364
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells2011
- Author(s)
  Oshima M, Endoh M, Endo TA, Toyoda T, Nakajima-Takagi Y, Sugiyama F, Koseki H, Kyba M, Iwama A, Osawa M
- Journal Title
  
  Blood
  
  Volume: 117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602006
[Journal Article] Epigenetic memory meets G2/M : to remember or to forget2011
- Author(s)
  Sharif J, Endoh M, Koseki H
- Journal Title
  
  Dev Cell
  
  Volume: 20 Pages: 5-6
- Data Source
  KAKENHI-PROJECT-21602006
[Journal Article] Mammalian Polycomblike Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate Polycomb activity at both the Hox gene cluster and at Cdkn2a genes2011
- Author(s)
  Li X, Isono KI, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N, Koseki H
- Journal Title
  
  Mol Cell Biol.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390088
[Journal Article] Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells.2011
- Author(s)
  Casanova M, Preissner T, Cerase A, Poot R, Yamada D, Li X, Appanah R, Bezstarosti K, Demmers J, Koseki H, Brockdorff N.
- Journal Title
  
  Development
  
  Volume: 138 Pages: 1471-82
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis2011
- Author(s)
  Mishima Y, Miyagi S, Saraya A, Negishi M, Endoh M, Endo TA, Toyoda T, Shinga J, Katsumoto T, Chiba T, Yamaguchi N, Kitabayashi I, Koseki H, Iwama A
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 2443-2453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602006
[Journal Article] Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes2011
- Author(s)
  Li X, Isono K, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N, Koseki H
- Journal Title
  
  Mol Cell Biol
  
  Volume: 31 Pages: 351-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602006
[Journal Article] Reproductive isolation in hybrid mice due to spermatogenesis defects at three meiotic stages. Spermatogenic Disruptions at Three Meiotic Stages in Hybrid Males Between House Mouse Subspecies or Species.2010
- Author(s)
  Oka A, Mita A, Takada Y, Koseki H, Shiroishi T.
- Journal Title
  
  Genetics
  
  Volume: 186 Pages: 339-351
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency2010
- Author(s)
  Pereira CF, Piccolo FM, Tsubouchi T, Sauer S, Ryan NK, Bruno L, Landeira D, Santos J, Banito A, Gil J, Koseki H, Merkenschlager M, Fisher AG
- Journal Title
  
  Cell Stem Cell. 6
  
  Pages: 547-556
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390088
[Journal Article] ESCs require PRC2 to direct the successful reprog ramming of differentiated cells toward pluripotency2010
- Author(s)
  Pereira CF, Piccolo FM, Tsubouchi T, Sauer S, Ryan NK, Bruno L, Landeira D, Santos J, Banito A, Gil J, Koseki H, Merkenschlager M, Fisher AG.
- Journal Title
  
  Cell Stem Cell 6
  
  Pages: 547-556
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] Mammalian Polycomblike Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate Polycomb activity at both the Hox gene cluster and at Cdkn2a genes2010
- Author(s)
  Li X, Isono KI, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N, Koseki H.
- Journal Title
  
  Mol Cell Biol
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.2010
- Author(s)
  Majewski IJ, Ritchie ME, Phipson B, Corbin J, Pakusch M, Ebert A, Busslinger M, Koseki H, Hu Y, Smyth GK, Alexander WS, Hilton DJ, Blewitt ME.
- Journal Title
  
  Blood.
  
  Volume: 116 Pages: 731-739
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.2010
- Author(s)
  Pereira CF, Piccolo FM, Tsubouchi T, Sauer S, Ryan NK, Bruno L, Landeira D, Santos J, Banito A, Gil J, Koseki H, Merkenschlager M, Fisher AG.
- Journal Title
  
  Cell Stem Cell.
  
  Volume: 6 Pages: 547-556
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] ヒストンH2Aのユビキチン化による遺伝子発現の制御2009
- Author(s)
  遠藤充浩、古関明彦
- Journal Title
  
  生体の科学
  
  Volume: 60巻 Pages: 533-540
- Data Source
  KAKENHI-PROJECT-21602006
[Journal Article] Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.2009
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Takaho A Endo, Tetsuro Toyoda, Jun Shinga, Haruhiko Koseki, Miguel Vidal, Yukiko Gotoh
- Journal Title
  
  Neuron 63(5)
  
  Pages: 600-613
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770231
[Journal Article] Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition2009
- Author(s)
  Hirabayashi Y, Suzki N, Tsuboi M, Endo TA, Toyoda T, Shinga J, Koseki H, Vidal M, Gotoh Y
- Journal Title
  
  Neuron 63
  
  Pages: 600-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770231
[Journal Article] Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity2008
- Author(s)
  Endoh M., Endo T.A., Endoh T., Fujimura Y., Ohara O., Toyoda T., Otte A.P., Okano M., Brockdorff N., Vidal M., Koseki H.
- Journal Title
  
  Development 135
  
  Pages: 1513-1524
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity2008
- Author(s)
  Endoh M., Endo T.A., Endoh T., Fujimura Y., Ohara O., Toyoda T., Otte A.P., Okano M., Brockdorff N., Vidal M., Koseki H.
- Journal Title
  
  Development 135
  
  Pages: 1513-1524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390088
[Journal Article] PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.2008
- Author(s)
  Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, van Lohuizen M, Peters AH.
- Journal Title
  
  Nat Genet.
  
  Volume: 40 Pages: 411-20
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains2008
- Author(s)
  Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A, Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES, Koseki H, Bernstein BE
- Journal Title
  
  PLoS Genet. 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390088
[Journal Article] Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains2008
- Author(s)
  Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A, Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES, Koseki H, Bernstein BE.
- Journal Title
  
  PLoS Genet 4
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062014
[Journal Article] 生殖細胞の発生分化のエピジェネティクス2007
- Author(s)
  高田幸、古関明彦
- Journal Title
  
  蛋白質核酸酵素 52
  
  Pages: 2163-2169
- Data Source
  KAKENHI-PROJECT-18051019
[Journal Article] Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes2007
- Author(s)
  Y.Takada, Isono, K., Shinga, J., Turner, J.M.A, Kitamura, H., Ohara, 0., Watanabe, G, Singh, P.B, Kamijo, T., Jenuwein, T., Burgoyne, P.S, Koseki, H
- Journal Title
  
  Development 134.3
  
  Pages: 579-590
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200032
[Journal Article] Control of developmental regulators by Polycomb in human embryonic stem cells2006
- Author(s)
  T.I.Lee, Jenner, R.G., Boyer, L.A., Guenther, M.G., Levine, S.S., Kumar, R.M., Chevalier, B., Johnstone, S.E., Cole, M.F., Isono, K, Koseki, H., Fuchikami, T., Abe, K., Murray, H.L, Zucker, J.P., Yuan, B., Bell, G.W., Herbolsheimer, E., Hannett, N.M., Sun, K., Odom, D.T., Otte, A.P., Volkert, T.L, Bartel, D.P., Melton, D.A., Gifford, D.K., Jaenisch, R., Young, R.A.
- Journal Title
  
  Cell 125
  
  Pages: 301-313
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200032
[Journal Article] Overlapping roles for homeodomain-interacting protein kinases Hipkl and Hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.2006
- Author(s)
  Isono, K., Nemoto, K., Li, Y., Takada, Y., Suzuki, R., Katsuki, M., Nakagawara, A., Koseki, H.
- Journal Title
  
  Molecular and Cellular Biology. 26(7)
  
  Pages: 2758-71
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13043003
[Journal Article] Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells2006
- Author(s)
  Lee T.I., Jenner R.G.., Boyer L.A., Guenther M.G.., Levine S.S., Kumar R.M., Chevalier B, Johnstone S.E., Cole M.F., Isono K, Koseki H, Fuchikami T, Abe K, Murray H.L.Zucker J.P., Yuan B, Bell G.W., Herbolsheimer E, Hannett N.M., Sun K, Odom D.T., Volkert T.L., Bartel D.P, Melton D.A., Gifford D.K., Jaenisch R, Young R.A.
- Journal Title
  
  Cell 125(2)
  
  Pages: 301-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13043003
[Journal Article] Distinct roles of Polycomb group gene products between transcriptionally repressed and active domains of Hoxb8.2006
- Author(s)
  Y.Fujimura, Isono, K, Vidal, M., Endoh, M., Kajita, H., Mizutani-Koseki, Y., Takihara, Y., van Lohuizen, M., Otte, A., Jenuwein, T., Deschamps, J., Koseki, H.
- Journal Title
  
  Development 133.12
  
  Pages: 2371-2381
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200032
[Journal Article] Mammalian Polycomb-mediated repression of Hox genes requires the essential spliceosomal protein sf3b1.2005
- Author(s)
  Isono K, Mizutani-Koseki Y, Komori T, Schmidt-Zachmann M.S, Koseki H.
- Journal Title
  
  Gene Dev. 19(5)
  
  Pages: 536-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13043003
[Journal Article] Mammalian polyhomeotic homologues Phc2 and Phc 1 act in synergy to mediate Polycomb-repression of Hox genes.2005
- Author(s)
  Isono K, Fujimura Y, Shinga J, Yamaki M, 0-Wang J, Takihara Y, Murahashi Y, Takada Y, Mizutani-Koseki Y, Koseki H.
- Journal Title
  
  Molecular and Cellular Biology. 25(15)
  
  Pages: 6694-706
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13043003
[Journal Article] Polycomb-group proteins RinglA/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.2004
- Author(s)
  Napoles M, Mermoud J, Wakao R, Tang Y.A, Endoh M, Appanah R, Nesterova T, Silva J, Otte A.P, Vidal M, KosekiH, Brockdorff N.
- Journal Title
  
  Dev. Cell 7(5)
  
  Pages: 663-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13043003
[Journal Article] Randomly inserted and targeted Hox/reporter fusions transcriptionally silenced in Polycomb mutants.2003
- Author(s)
  d Graaff W, Tomotsune D, Oosterveen T, Takihara Y, Koseki H, Deschamps J.
- Journal Title
  
  Pmc Natl Acad Sci U S A.1l 100(23)
  
  Pages: 13362-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13043003
[Journal Article] Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.2002
- Author(s)
  Suzuki, M., Mizutani-Koseki, Y., Fujimura, Y., Miyagishima, H.Kaneko, T., Takada, Y., Akasaka, T., Tanzawa, H., Taldhara, Y., Nakano, M., Masumoto, H., Vidal, M., Isono K.Koseki, H.
- Journal Title
  
  Development 129
  
  Pages: 4171-4183
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13043003
[Journal Article] The role of Presenilin1 during somite segmentation.2001
- Author(s)
  Koizumi, K., Nakajima, M., Yuasa, S., Saga, Y., Sakai, T., Kuriyama, T., Shirasawa, T., Koseki,H.
- Journal Title
  
  Development 128
  
  Pages: 1391-1402
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13043003
[Journal Article] Mice doubly deficient for the Polycomb-Groupe genes Me118 and Bmil reveal synergy and requirement for maintenance but not initiation of Hox gene expression.2001
- Author(s)
  Akasaka, T., van Lohuizen, M.van der Lugt, N., Mizutani-Koseki, Y., Kanno, M., Taniguchi, M., Vidal, M., Alkema, M., Berns, A., Koseki,H.
- Journal Title
  
  Development. 128
  
  Pages: 1587-1597
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13043003
[Journal Article] Distinct roles of Polycomb group gene products between transcriptionally repressed and active domains of Hoxb8.2000
- Author(s)
  Fujimura Y, Isono K, Vidal M, Endoh M, Kajita H, Mizutani-Koseki Y, Takihara Y, van Lohuizen M, Otte A, Jenuwein T, Deschamps J, Koseki H
- Journal Title
  
  Development 133(12)
  
  Pages: 2371-2381
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13043003
[Patent] ES細胞の製造方法2011
- Inventor(s)
  古関明彦
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2011-04-01
- Data Source
  KAKENHI-PLANNED-20062014
[Patent] ES細胞の製造方法2011
- Inventor(s)
  古関明彦
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2011-04-01
- Overseas
- Data Source
  KAKENHI-PROJECT-20390088
[Patent] 変異体FGF2008
- Inventor(s)
  古関明彦
- Industrial Property Rights Holder
  国立大学法人千葉大学、独立行政法人理化学研究所
- Industrial Property Number
  2008-081826
- Filing Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-20390088
[Patent] 変異体FGF2008
- Inventor(s)
  古関明彦
- Industrial Property Rights Holder
  独立行政法人理化学研究所、国立大学法人千葉大学
- Industrial Property Number
  2008-081826
- Filing Date
  2008-03-26
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] ポリコム群によるCpGアイランドの機能制御2024
- Author(s)
  古関　明彦
- Organizer
  北海道大学化学反応創成研究拠点 (ICReDD) 第６回ゲノム生物物理学セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] Polycomb Repressive Complex in Development and Homeostasis2023
- Author(s)
  Haruhiko Koseki
- Organizer
  Research Team Promoting Grant Annual Meeting 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] SKP1A links Polycomb-repressed genes with proteasome2023
- Author(s)
  Haruhiko Koseki
- Organizer
  Trinity College Dublin
- Invited
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] CpG Island-Bound SKP1A Links EED with Proteasomal Degradation and Gene Activation of Polycomb Target Genes2023
- Author(s)
  Haruhiko Koseki
- Organizer
  2023 Epigenetics Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] SKP1A links Polycomb-repressed genes with proteasome2023
- Author(s)
  Haruhiko Koseki
- Organizer
  IMSGC2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] SKP1A links Polycomb-repressed genes with proteasome2023
- Author(s)
  Haruhiko Koseki
- Organizer
  University of Dundee
- Invited
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] SKP1A links Polycomb-repressed genes with proteasome2023
- Author(s)
  Haruhiko Koseki
- Organizer
  University of Oxford
- Invited
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] SKP1A links Polycomb-repressed genes with proteasome2023
- Author(s)
  Haruhiko Koseki
- Organizer
  EMBL Conference Chromatin and epigenetics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] SKP1A links Polycomb-repressed genes with proteasome2023
- Author(s)
  Haruhiko Koseki
- Organizer
  Cambridge epigenetics club (University of Cambridge)
- Invited
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] SKP1A links Polycomb-repressed genes with proteasome2022
- Author(s)
  Haruhiko Koseki
- Organizer
  沖縄科学技術大学院大学（OIST)セミナー
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] The role for variant PRC1 during transcriptional phase transition2022
- Author(s)
  Haruhiko Koseki
- Organizer
  University of Oxfordセミナー
- Invited
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] Polycombing development2022
- Author(s)
  Haruhiko Koseki
- Organizer
  Tianjin Medical Universityセミナー
- Invited
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] The role for variant PRC1 during transcriptional phase transition2022
- Author(s)
  Haruhiko Koseki
- Organizer
  University of Copenhagen セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment2022
- Author(s)
  Haruhiko Koseki
- Organizer
  The 5th Tsinghua -RIKEN Joint Workshop on Recent Progress in Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] The role for variant PRC1 during transcriptional phase transition2022
- Author(s)
  Haruhiko Koseki
- Organizer
  Friedrich Miescher Institute for Biomedical Research (FMI)セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] ポリコム群による抑制ドメインの複製機構の解明2020
- Author(s)
  古関　明彦
- Organizer
  第１回新学術領域「非ゲノム情報複製」領域会議
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Proteasomal regulation of variant PCGF1-PRC1 contributes to activation of Polycomb target genes via self-ubiquitination2020
- Author(s)
  Haruhiko Koseki
- Organizer
  U Tokyo's LSBM Symposium 2020 in Hakone
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] Polycomb in haematipoietic differentiation2020
- Author(s)
  古関　明彦
- Organizer
  The Chromatin and Epigenetics biweekly virtual seminar series, Tsinghua University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Polycomb in haematipoietic differentiation2020
- Author(s)
  古関　明彦
- Organizer
  The Chromatin and Epigenetics biweekly virtual seminar series, Tsinghua University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] ポリコム群による抑制ドメインの複製機構の解明2020
- Author(s)
  古関　明彦
- Organizer
  第１回新学術領域「非ゲノム情報複製」領域会議
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] 哺乳類ポリコム群による発生過程の制御　Variant PRC1 in cellular differentiation2019
- Author(s)
  Haruhiko Koseki
- Organizer
  日本遺伝学会第91回大会
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Variant PRC1 in cellular differentiation2019
- Author(s)
  Haruhiko Koseki
- Organizer
  Friedrich Miescher Institute for Biomedical Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] Variant PRC1 in cellular differentiation2019
- Author(s)
  Haruhiko Koseki
- Organizer
  Keble College
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] ポリコム、分化、複製2019
- Author(s)
  Haruhiko Koseki
- Organizer
  新学術領域「多様かつ堅牢な細胞形質をさせる非ゲノム情報複製機構」第1回領域会議
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] 哺乳類ポリコム群による発生過程の制御　Variant PRC1 in cellular differentiation2019
- Author(s)
  Haruhiko Koseki
- Organizer
  日本遺伝学会第91回大会
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] 疾患生物学：マウスからヒトへどう読み替えるか？2019
- Author(s)
  Haruhiko Koseki
- Organizer
  千葉大学消化器内科セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] Variant PRC1 in cellular differentiation2019
- Author(s)
  Haruhiko Koseki
- Organizer
  Friedrich Miescher Institute for Biomedical Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] ポリコム、分化、複製2019
- Author(s)
  Haruhiko Koseki
- Organizer
  新学術領域「多様かつ堅牢な細胞形質をさせる非ゲノム情報複製機構」第1回領域会議
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] Variant PRC1 in cellular differentiation2019
- Author(s)
  Haruhiko Koseki
- Organizer
  Keble College
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] The role for enhancer of polycomb in chromatin replication and epigenetic inheritance2019
- Author(s)
  Haruhiko Koseki
- Organizer
  3rd RIKEN IMS-Stanford ISCBRM Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Variant PCGF1-PRC1 is linked to proteasomal pathway to activate Polycomb target genes during development2019
- Author(s)
  Haruhiko Koseki
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Variant PCGF1-PRC1 is linked to proteasomal pathway to activate Polycomb target genes during development2019
- Author(s)
  Haruhiko Koseki
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] The role for enhancer of polycomb in chromatin replication and epigenetic inheritance2019
- Author(s)
  Haruhiko Koseki
- Organizer
  3rd RIKEN IMS-Stanford ISCBRM Joint Symposium
- Invited
- Data Source
  KAKENHI-PLANNED-19H05745
[Presentation] Polycomb in development2018
- Author(s)
  Haruhiko Koseki
- Organizer
  Shandong University School of Life ScienceJinan, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Functional analysis of DDX41 germline and somatic mutations in myeloid neoplasms.2018
- Author(s)
  Ayana Kon, June Takeda, Keisuke Kataoka, Kenichi Yoshida, Masahiro Marshall Nakagawa, Tetsuichi Yoshizato, Manabu Nakayama, Haruhiko Koseki, Hideki Makishima, Seishi Ogawa
- Organizer
  The 80th Annual Meeting of the Japanese Society of Hematology
- Data Source
  KAKENHI-PROJECT-26221308
[Presentation] Variant PRC1 in gene activation and inactivation2018
- Author(s)
  Haruhiko Koseki
- Organizer
  Curie Institute
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Polycomb in development2018
- Author(s)
  Haruhiko Koseki
- Organizer
  Shandong University School of Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Functional analysis of DDX41 germline and somatic mutations in myeloid neoplasms.2018
- Author(s)
  Ayana Kon, June Takeda, Keisuke Kataoka, Kenichi Yoshida, Masahiro Marshall Nakagawa, Tetsuichi Yoshizato, Manabu Nakayama, Haruhiko Koseki, Hideki Makishima, Seishi Ogawa
- Organizer
  77th Anulal Meeeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-26221308
[Presentation] variant PRC1.1 in transcriptional phase transition2018
- Author(s)
  Haruhiko Koseki
- Organizer
  Friedrich Miescher Institute for Biomedical Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Polycomb in development2018
- Author(s)
  Haruhiko Koseki
- Organizer
  Cold Spring Harbor Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Stag2 regulates hematopoietic differentiation and self-renewal2018
- Author(s)
  Yotaro Ochi, Ayana Kon, Masahiro Marshall Nakagawa, Keisuke Kataoka, Kenichi Yoshida, Haruhiko Koseki, Manabu Nakayama, Akinori Yoda, Hideki Makishima, Akifumi Takaori-Kondo2, and Seishi Ogawa
- Organizer
  23rd Congress of European Hematology Association (EHA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221308
[Presentation] Induced activation of Polycomb-repressed　genes in mice2018
- Author(s)
  Haruhiko Koseki
- Organizer
  The European Molecular Biology Laboratory (EMBL)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Variant PRC1 in gene activation and inactivation2018
- Author(s)
  Haruhiko Koseki
- Organizer
  Keble College
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Meis2 activation by Kdm2b-containing complexesThe Babraham Institute2017
- Author(s)
  Koseki H
- Organizer
  The Babraham Institute
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Biological characterization of DDX41 germline and somatic mutations in myeloid neoplasms.2017
- Author(s)
  Ayana Kon, Keisuke Kataoka, Hideki Makishima, June Takeda, Tetsuichi Yoshizato, Masahiro Nakagawa, Yasunori Kogure, Kenichi Yoshida, Manabu Nakayama, Haruhiko Koseki, Seishi Ogawa
- Organizer
  日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19574
[Presentation] Gene regulation by Polycomb variants2017
- Author(s)
  Koseki H
- Organizer
  RIKEN-McGill Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Stag2 regulates Hematopoietic Differentiation and Self-Renewal2017
- Author(s)
  Yotaro Ochi, Ayana Kon, Kenichi Yoshida, Keisuke Kataoka, Masahiro Marshall Nakagawa, Hideki Makishima, Manabu Nakayama, Haruhiko Koseki, Akifumi Takaori-Kondo, and Seishi Ogawa
- Organizer
  The 59th American Society of Hematology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221308
[Presentation] Cohesin subunit Stag2 regulates Hematopoietic Differentiation and Self-Renewal2017
- Author(s)
  Yotaro Ochi, Ayana Kon, Kenichi Yoshida, Keisuke Kataoka, Masahiro Marshall Nakagawa, Manabu Nakayama, Haruhiko Koseki, Akifumi Takaori-Kondo, and Seishi Ogawa
- Organizer
  The 79th Annual Meeting of the Japanese Society of Hematology
- Data Source
  KAKENHI-PROJECT-26221308
[Presentation] Biological characterization of DDX41 germline and somatic mutations in myeloid neoplasms.2017
- Author(s)
  Ayana Kon, Keisuke Kataoka, June Takeda, Tetsuichi Yoshizato, Masahiro Nakagawa, Yasunori Kogure, Kenichi Yoshida, Manabu Nakayama, Haruhiko Koseki, Hideki Makishima, Seishi Ogawa
- Organizer
  日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16K19574
[Presentation] Biological characterization of DDX41 germline and somatic mutations in myeloid neoplasms.2017
- Author(s)
  Ayana Kon, Keisuke Kataoka, Hideki Makishima, June Takeda, Tetsuichi Yoshizato, Masahiro Nakagawa, Yasunori Kogure, Kenichi Yoshida, Manabu Nakayama, Haruhiko Koseki, Seishi Ogawa
- Organizer
  The 79th Annual Meeting of the Japanese Society of Hematology
- Data Source
  KAKENHI-PROJECT-26221308
[Presentation] Meis2 activation by Kdm2b-containing complexesOxford University2017
- Author(s)
  Koseki H
- Organizer
  Oxford University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] 「iPS 細胞由来NKT 細胞によるがん治療技術の開発」 Development of adoptive immunotherapy for cancer using iPS-derived NKT cells2017
- Author(s)
  Koseki H
- Organizer
  第21回日本がん免疫学会総会 The 21st Annual Meeting of Japanese Association of Cancer Immunology
- Invited
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Meis2 regulation by Kdm2b complexes in developing midbrain2017
- Author(s)
  Koseki H
- Organizer
  Biotech Research & Innovation Centre (BRIC) University of Copenhagen
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Polycomb-mediated regulation of transition of transcriptional status2017
- Author(s)
  Koseki H
- Organizer
  第69回日本細胞生物学会大会 The 69th Annual Meeting of the Japan Sciety for Cell Biology
- Invited
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Clinical potential of iPS cell-derived invariant NKT cells2017
- Author(s)
  Koseki H
- Organizer
  Stanford ISCBRM-RIKEN IMS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Meis2 activation by Kdm2b-containing complexes2017
- Author(s)
  Koseki H
- Organizer
  Smurfit Institute of Genetics, Trinity College Dublin
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Activating Polycomb-repressed genes in mammals2017
- Author(s)
  Koseki H
- Organizer
  France-Japan Epigenetics Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Meis2 regulation by Kdm2b complexes in developing midbrain2017
- Author(s)
  Koseki H
- Organizer
  Friedrich Miescher Institute for Biomedical Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Cohesin subunit Stag2 regulates Hematopoietic Differentiation and Self-Renewal2017
- Author(s)
  Yotaro Ochi, Ayana Kon, Kenichi Yoshida, Keisuke Kataoka, Masahiro Marshall Nakagawa, Manabu Nakayama, Haruhiko Koseki, Akifumi Takaori-Kondo, and Seishi Ogawa
- Organizer
  The 76th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-26221308
[Presentation] Biological characterization of DDX41 germline and somatic mutations in myeloid neoplasms.2017
- Author(s)
  Ayana Kon, Keisuke Kataoka, June Takeda, Tetsuichi Yoshizato, Masahiro Nakagawa, Yasunori Kogure, Kenichi Yoshida, Manabu Nakayama, Haruhiko Koseki, Hideki Makishima, Seishi Ogawa
- Organizer
  The 76th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-26221308
[Presentation] PCGF6-PRC1 to suppress premature activation of meiosis/germ cell related genes in ES cells2016
- Author(s)
  古関　明彦
- Organizer
  Trinity College, Oxford University
- Place of Presentation
  Oxford, UK
- Year and Date
  2016-06-27
- Invited
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] The biological characterization of Srsf2 P95H mutation in the pathogenesis of myelodysplasia2016
- Author(s)
  Ayana Kon, Satoshi Yamazaki, Yusuke Shiozawa, Keisuke Kataoka, Yasunori Ota, Maiko Morita, Tetsuichi Yoshizato, Masashi Sanada, Kenichi Yoshida, Hideki Makisima, Yasuhito Nanya, Shinichi Kotani, June Takeda, Yosaku Watatani, Yotaro Ochi, Manabu Nakayama, Haruhiko Koseki, Hiromitsu Nakauchi, Seishi Ogawa
- Organizer
  The 78th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Yokohama, Kanagawa, Japan
- Data Source
  KAKENHI-PROJECT-16K19574
[Presentation] Protoracted NP95 binding to hemimethlated 1 DNA disrupts SETB1-mediated proviral silencing2016
- Author(s)
  古関明彦
- Organizer
  International Symposium on "Chromosome Orchestration System", Osaka University
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県淡路市）
- Year and Date
  2016-03-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Regulation of promoter/enhancer interaction of Meis2 by KDM2B2016
- Author(s)
  古関　明彦
- Organizer
  Centro de investigaciones Biológicas (CSIC)
- Place of Presentation
  Madrid, Spain
- Year and Date
  2016-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] The role of PRC1 variants during activation of Meis22016
- Author(s)
  古関　明彦
- Organizer
  Max-Planck Institute of Immunobiology and Epigenetics
- Place of Presentation
  Freiburg, Germany
- Year and Date
  2016-11-11
- Invited
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] PCGF6-PRC1 to suppress premature activation of meiosis/germ cell related genes in ES cells2016
- Author(s)
  古関　明彦
- Organizer
  Basel Stem Cell Network, Freidrich Miescher Institute
- Place of Presentation
  Basel, Switzerland
- Year and Date
  2016-06-23
- Invited
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] The biological characterization of Srsf2 P95H mutation in the pathogenesis of myelodysplasia2016
- Author(s)
  Ayana Kon, Satoshi Yamazaki, Yusuke Shiozawa, Keisuke Kataoka, Yasunori Ota, Maiko Morita, Tetsuichi Yoshizato, Masashi Sanada, Kenichi Yoshida, Hideki Makisima, Yasuhito Nanya, Shinichi Kotani, June Takeda, Yosaku Watatani, Yotaro Ochi, Manabu Nakayama, Haruhiko Koseki, Hiromitsu Nakauchi, Seishi Ogawa
- Organizer
  The 78th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Yokohama,Japan
- Data Source
  KAKENHI-PROJECT-26221308
[Presentation] 形態形成のエピジェネティック制御2016
- Author(s)
  古関　明彦
- Organizer
  秋田大学大学院医学系研究科・医学部
- Place of Presentation
  Madrid, Spain
- Year and Date
  2016-06-07
- Invited
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Polycomb in transcriptional phase transition of developmental genes2016
- Author(s)
  古関　明彦
- Organizer
  Mini Symposium, Genetic Control of Mouse embryonic Development at Hubrecht Institute
- Place of Presentation
  Utrecht, the Netherlands
- Year and Date
  2016-06-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02622
[Presentation] Protracted NP95 binding to hemimethylated DNA disrupts proviral silencing2015
- Author(s)
  古関明彦
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] 形態形成のエピジェネティック制御2015
- Author(s)
  古関明彦
- Organizer
  大阪大学蛋白質研究所セミナー　エピジェネティクス－分子機構から高次機能まで－
- Place of Presentation
  大阪大学蛋白質研究所1階講堂（大阪府吹田市）
- Year and Date
  2015-12-11
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Coordination of heterochromatin byNp95/Uhrf12014
- Author(s)
  Koseki H
- Organizer
  Seminar at University of Oxford
- Place of Presentation
  Oxford, UK
- Year and Date
  2014-09-23
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Activation of polycomb-repressed genes2014
- Author(s)
  Koseki H.
- Organizer
  Trinity College Seminar Series
- Place of Presentation
  Dublin, Ireland
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Activation of polycomb-repressed genes2014
- Author(s)
  Koseki H.
- Organizer
  Seminar at Ecole polytechnique federale de Lausanne
- Place of Presentation
  Lausanne, Switzerland
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Coordination of heterochromatin byNp95/Uhrf12014
- Author(s)
  Koseki H
- Organizer
  Seminar at MRC Clinical Sciences Centre, Imperial College London
- Place of Presentation
  London, UK
- Year and Date
  2014-09-22
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Coordination of heterochromatin byNp95/Uhrf12014
- Author(s)
  Koseki H
- Organizer
  Seminar at Biotech Research and Innovation Centre, University of Copenhagen
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-09-29
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] iPS細胞技術を介したNKT細胞療法の開発2014
- Author(s)
  古関明彦
- Organizer
  第35回日本炎症・再生医学会シンポジウム6 「未来の再生医療」
- Place of Presentation
  沖縄県名護市　万国津梁館
- Year and Date
  2014-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Activation of polycomb-repressed genes2013
- Author(s)
  Koseki H.
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  Chiba, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Activation of polycomb-repressed genes2013
- Author(s)
  Koseki H.
- Organizer
  Mouse Molecular Genetics Conference
- Place of Presentation
  Cambridge, UK
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] DNA methylation in T cells and gut immune homeostasis2013
- Author(s)
  Koseki H.
- Organizer
  3rd McGill-RIKEN Workshop
- Place of Presentation
  Montreal, Canada
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Polycomb potentiates Meis2 activation in midbrain by mediating precursory interaction of promoter with tissue-specific enhance2013
- Author(s)
  古関明彦
- Organizer
  RCAI-Michigan Joint Workshop
- Place of Presentation
  米国、アナーバー
- Year and Date
  2013-01-16
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Epigetic regulation of spermiogenesis2013
- Author(s)
  Koseki H.
- Organizer
  The 10th Annual Meeting of Asian Reproductive Biotechnology Society
- Place of Presentation
  Phan Thiet, Vietnam
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Polycomb potentiates Meis2 activation in midbrain by mediating precursory interaction of promoter with tissue-specific enhance2013
- Author(s)
  Koseki H
- Organizer
  RCAI-Michigan Joint Workshop
- Place of Presentation
  米国、アナーバー(招待講演)
- Year and Date
  2013-01-16
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Mechanisms underlying Polycomb repression2012
- Author(s)
  Koseki H
- Organizer
  文部科学省新学術領域「細胞運命制御」
- Place of Presentation
  日本、京都(招待講演)
- Year and Date
  2012-11-06
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Mechanisms underlying Polycomb repression2012
- Author(s)
  古関明彦
- Organizer
  文部科学省新学術領域細胞運命制御
- Place of Presentation
  日本、京都
- Year and Date
  2012-11-06
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] ポリコーム群Ring1A/BによるヒストンH2Aユビキチン化のES細胞における局在と役割2012
- Author(s)
  遠藤充浩、遠藤高帆、磯野協一、古関明彦
- Organizer
  第6回エピジェネティクス研究会
- Place of Presentation
  東京一ツ橋学術総合センター
- Data Source
  KAKENHI-PROJECT-21602006
[Presentation] ポリコム群の機能発現メカニズム2012
- Author(s)
  Koseki H
- Organizer
  第4回シグナルネットワーク研究会
- Place of Presentation
  日本、大阪(招待講演)
- Year and Date
  2012-05-18
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] ポリコム群の機能発現メカニズム2012
- Author(s)
  古関明彦
- Organizer
  第4回シグナルネットワーク研究会
- Place of Presentation
  日本、大阪
- Year and Date
  2012-05-18
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Temporal Regulation of Cortical Neural Precursor Cell Fate by Polycomb Group Proteins2011
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
- Organizer
  CDB Symposium 2011
- Place of Presentation
  理化学研究所発生・再生科学総合研究センター(神戸市)
- Year and Date
  2011-03-15
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] Application of iPS Cell Technology for NKT Cell-targeted Adjuvant Therapy for Tumors in Mice2011
- Author(s)
  Koseki H
- Organizer
  14th US-Japan Cellular and Gene Therapy Confe rence
- Place of Presentation
  米国、ベセスダ
- Year and Date
  2011-02-24
- Invited
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] SAM domain-mediated polymerization of mammalian polyhomeotic homologues mediates recruitment of PRC1 to Polycomb target genes and their condensation2011
- Author(s)
  古関明彦
- Organizer
  3rd X-inactivation meeting
- Place of Presentation
  英国、オックスフォード
- Year and Date
  2011-07-23
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] SAM domain-mediated polymerization of mammalian polyhomeotic homologues mediates recruitment of PRC1 to Polycomb target genes and their condensation2011
- Author(s)
  Koseki H
- Organizer
  3rd X-inactivation meeting
- Place of Presentation
  英国、オックスフォード(招待講演)
- Year and Date
  2011-07-23
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] H2A ubiquitination is an essential step to mediate PRC1 Polycomb silencing of differentiation genes in ES cells2011
- Author(s)
  Endoh M and Koseki H
- Organizer
  第9回幹細胞シンポジウム
- Place of Presentation
  泉ガーデンギャラリー、東京
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-21602006
[Presentation] Polycomb-dependent regulation for differentiation programs of stem cells and progenitors2011
- Author(s)
  Koseki H
- Organizer
  アジアエピゲノムワークショップ/第五回日本エピジェネティクス研究会
- Place of Presentation
  日本、熊本市(招待講演)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2011
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
- Organizer
  CDB Symposium
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] SAM domain-mediated polymerization of mammalian polyhomeotic homologues mediates recruitment of PRC1 to Polycomb target genes and their condensation2011
- Author(s)
  Koseki H
- Organizer
  3rd X-inactivation meeting
- Place of Presentation
  英国、オックスフォード(招待講演)
- Year and Date
  2011-07-23
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Application of iPS Cell Technology for NKT Cell-targeted Adjuvant Therapy for Tumors in Mice2011
- Author(s)
  Koseki H
- Organizer
  14th US-Japan Cellular and Gene Therapy Conference
- Place of Presentation
  米国、ベセスダ(招待講演)
- Year and Date
  2011-02-24
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Polycomb-dependent regulation for differentiation programs of stem cells and progenitors2011
- Author(s)
  Koseki H
- Organizer
  アジアエピゲノムワークショップ/第五回日本エピジェネティクス研究会
- Place of Presentation
  日本、熊本市(招待講演)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Polycomb-dependent regulation for differentiation programs of stem cells and progenitors2011
- Author(s)
  古関明彦
- Organizer
  アジアエピゲノムワークショップ/ 第五回日本エピジェネティクス研究会
- Place of Presentation
  日本、熊本市
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] ユビキチン化ヒストンH2AのES細胞における局在と役割2011
- Author(s)
  遠藤充浩、遠藤高帆、磯野協一、古関明彦
- Organizer
  第5回エピジェネティクス研究会
- Place of Presentation
  KKRホテル熊本
- Data Source
  KAKENHI-PROJECT-21602006
[Presentation] 遺伝現象におけるエピジェネティック制御とリプログラミング2010
- Author(s)
  Koseki H
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  日本、大阪市
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] 遺伝現象におけるエピジェネティック制御とリプログラミング2010
- Author(s)
  Koseki H
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪,日本
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2010
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
- Organizer
  Keystone Symposium-Dynamics of Eukaryotic Transcription during Development
- Place of Presentation
  BIg Sky, USA
- Year and Date
  2010-04-08
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] The role of Polycomb body to mediate Hox repression2010
- Author(s)
  Koseki H
- Organizer
  東京大学分子細胞生物学研究所核内情報研究分野シンポジウム
- Place of Presentation
  日本、東京都
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] 遺伝現象におけるエピジェネティック制御とリプログラミング2010
- Author(s)
  古関明彦
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  日本、大阪市
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] The role of Polycomb body to mediate Hox repression2010
- Author(s)
  Koseki H
- Organizer
  東京大学分子細胞生物学研究所核内情報研究分野シンポジウム
- Place of Presentation
  東京、日本
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] Polycomb-dependent regulation for differentiation programs of stem cells and progenitors2010
- Author(s)
  古関明彦
- Organizer
  第16回国際分化学会国際会議
- Place of Presentation
  日本、奈良市
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] プロモーターアレイを用いたポリコーム群によるES細胞維持メカニズムの解析2010
- Author(s)
  Koseki H
- Organizer
  日本エピジェネティクス研究会第4回年会
- Place of Presentation
  日本、米子市
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] プロモーターアレイを用いたポリコーム群によるES細胞維持メカニズムの解析2010
- Author(s)
  Koseki H
- Organizer
  日本エピジェネティクス研究会第4回年会
- Place of Presentation
  米子,日本
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2010
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
- Organizer
  Minisymposium on Developmental Neurobiology
- Place of Presentation
  San Diego, CA
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] プロモーターアレイを用いたポリコーム群によるES細胞維持メカニズムの解析2010
- Author(s)
  Koseki H
- Organizer
  日本エピジェネティクス研究会第4回年会
- Place of Presentation
  日本、米子市
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2010
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
- Organizer
  2nd German-Japanese Neurogenesis Meeting 2010
- Place of Presentation
  Spreewald, Germany
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] The role of Polycomb body to mediate Hox repression2010
- Author(s)
  Koseki H
- Organizer
  東京大学分子細胞生物学研究所核内情報研究分野
- Place of Presentation
  日本、東京都(シンポジウム)
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] The role of Polycomb body to mediate Hox repression2010
- Author(s)
  古関明彦
- Organizer
  東京大学分子細胞生物学研究所核内情報研究分野シンポジウム
- Place of Presentation
  日本、東京都
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Polycomb temporally regulates trophoblast development by promoting stem cell differentiation2010
- Author(s)
  Endoh M, Endo TA, and Koseki H
- Organizer
  第8回幹細胞シンポジウム
- Place of Presentation
  淡路夢舞台国際会議場
- Data Source
  KAKENHI-PROJECT-21602006
[Presentation] ポリコーム群とコアな転写因子のクロストークによる栄養芽幹細胞の分化制御2010
- Author(s)
  遠藤充浩、遠藤高帆、古関明彦
- Organizer
  第4回日本エピジェネティクス研究会
- Place of Presentation
  米子市文化ホール
- Data Source
  KAKENHI-PROJECT-21602006
[Presentation] ポリコーム群は転写因子の抑制を介して栄養芽幹細胞の分化を促進する2010
- Author(s)
  遠藤充浩、遠藤高帆、古関明彦
- Organizer
  第43回日本発生生物学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-21602006
[Presentation] Polycomb-dependent regulation for differentiation programs of stem cells and progenitors2010
- Author(s)
  Koseki H
- Organizer
  第16回国際分化学会国際会議
- Place of Presentation
  奈良、日本
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] Polycomb-dependent regulation for differentiation programs of stem cells and progenitors2010
- Author(s)
  Koseki H
- Organizer
  第16回国際分化学会国際会議
- Place of Presentation
  日本、奈良市
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] ポリコーム群タンパク質による大脳皮質神経系前駆細胞の分化運命制御2009
- Author(s)
  平林祐介、鈴木菜央、壷井將史、Miguel Vidal, 古関明彦, 後藤由季子
- Organizer
  第82回日本生化学会大会(口頭発表)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] PRC1 suppresses ES cell differentiation programs through PRC2-dependent and PRC2-independent mechanisms2009
- Author(s)
  遠藤充浩、遠藤高帆、古関明彦
- Organizer
  第19回日本数理生物学会年会
- Place of Presentation
  東京大学駒場キャンパス
- Data Source
  KAKENHI-PROJECT-21602006
[Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2009
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
- Organizer
  EuroEpiStem--2009 Meeting
- Place of Presentation
  Cambridge, UK
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] ポリコーム群タンパク質による大脳皮質神経系前駆細胞の分化運命制御2009
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] ES細胞におけるポリコーム群の動き2009
- Author(s)
  Koseki H
- Organizer
  第42回日本発生生物学会年会
- Place of Presentation
  京都、日本
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] PRC1 suppresses ES cell differentiation programs through PRC2-dependent and PRC2-independent mechanisms2009
- Author(s)
  Endoh M, Endo TA, Endoh T, Vidal M, and Koseki H
- Organizer
  Cold Spring Harbor Laboratory Meeting
- Place of Presentation
  Cambridge, UK
- Data Source
  KAKENHI-PROJECT-21602006
[Presentation] HP1g links histone H3K9 methylation to homologus chromosome pairing during melotic prophase2009
- Author(s)
  Koseki H
- Organizer
  he Epigenetics 2009 Australian Scientific Conference@Epigenetics and Development
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] ES細胞におけるポリコーム群の動き2009
- Author(s)
  Koseki H
- Organizer
  第42回日本発生生物学会年会
- Place of Presentation
  京都、日本
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] HP1g links histone H3K9 methylation to homologus chromosome pairing during melotic prophase2009
- Author(s)
  古関明彦
- Organizer
  The Epigenetics 2009 Australian Scientific Conference@Epigenetics and Development
- Place of Presentation
  オーストラリア、ブリスベン
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] ポリコーム群Ring1A/Bによるヒストン修飾を介した幹細胞制御2009
- Author(s)
  遠藤充浩、遠藤高帆、古関明彦
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-21602006
[Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2009
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
- Organizer
  EuroEpiStem-2009 Meeting
- Place of Presentation
  Cambridge, UK
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2009
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
- Organizer
  ISSCR 8th Annual Meeting
- Place of Presentation
  (Barcelona, Spain) Poster presentation
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] ポリコーム群Ring1A/Bによるヒストン修飾を介した幹細胞制御2009
- Author(s)
  遠藤充浩、遠藤高帆、古関明彦
- Organizer
  第3回日本エピジェネティクス研究会年会
- Place of Presentation
  東京一ツ橋学術総合センター
- Data Source
  KAKENHI-PROJECT-21602006
[Presentation] Roles of Polycomb group proteins Ring1A/B in mouse ES cells and TS cells2009
- Author(s)
  遠藤充浩、古関明彦
- Organizer
  第7回幹細胞シンポジウム
- Place of Presentation
  学術総合センター
- Data Source
  KAKENHI-PROJECT-21602006
[Presentation] ES細胞におけるポリコーム群の動き2009
- Author(s)
  古関明彦
- Organizer
  第42回日本発生生物学会年会
- Place of Presentation
  日本、京都
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition2009
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
- Organizer
  Keystone Symposia-Chromatin Dynamics and Higher Order Organization
- Place of Presentation
  (Coeurd'Alene, ID) Poster presentation
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] HP1g links histone H3K9 methylation to homologus chromosome pairing during melotic prophase2009
- Author(s)
  Koseki H
- Organizer
  The Epigenetics 2009 Australian Scientific Conference@Epigenetics and Development
- Place of Presentation
  ブリスベン、豪州
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] HP1g links histone H3K9 methylation to homologus chromosome pairing during melotic prophase2009
- Author(s)
  Koseki H
- Organizer
  The Epigenetics 2009 Australian Scientific Conference@Epigenetics and Development
- Place of Presentation
  ブリスベン、豪州
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2009
- Author(s)
  Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
- Organizer
  ISSCR 8th Annual Meeting
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2009-07-09
- Data Source
  KAKENHI-PROJECT-21770231
[Presentation] Polycom repression mediates mediates pluripotency of ES cells2008
- Author(s)
  Koseki H
- Organizer
  Cold Spring Harbor Laboratory,
- Place of Presentation
  New York, U.S.A
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Mouse development: embryogenesis2008
- Author(s)
  古関明彦
- Organizer
  EMBO Practical Course on Anatomy and Embryology of the Mouse
- Place of Presentation
  クロアチア、ザグレブ
- Year and Date
  2008-09-06
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Histone H2A ubiquitinylation subdivides bivalent genes into PRC1-dependent and independent domains in ES cells2008
- Author(s)
  Koseki H
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会、合同大会
- Place of Presentation
  神戸, 日本
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Polycom repression mediates pluripotency of ES cells2008
- Author(s)
  古関明彦
- Organizer
  Cold Spring Harbor Laboratory
- Place of Presentation
  アメリカ、ニューヨーク
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Polycom repression mediates pluripotency of ES cells2008
- Author(s)
  Koseki H
- Organizer
  Cold Spring Harbor Laboratory
- Place of Presentation
  New York, U.S.A.
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] Mouse development : embryogenesis2008
- Author(s)
  Koseki H
- Organizer
  EMBO Practical Course on Anatomy and Embryology of the Mouse
- Place of Presentation
  Zagreb, Croatia
- Year and Date
  2008-09-06
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] Histone H2A ubiquitinylation subdivides bivalent genes into PRC1-dependent and -independent domains in ES cells2008
- Author(s)
  Koseki H
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会、合同大会
- Place of Presentation
  神戸,日本
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] Polycomb group proteins Ring1A/B are functionally linked to the coretranscriptional regulatory circuitry to maintain ES cell identity2008
- Author(s)
  Koseki H
- Organizer
  Shanghai Cancer Institute
- Place of Presentation
  Shanghai, China
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] Histone H2A ubiquitinylation subdivides bivalent genes into PRC1-dependent and-independent domains in ES cells2008
- Author(s)
  Koseki H
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会、合同大会
- Place of Presentation
  神戸,日本
- Data Source
  KAKENHI-PROJECT-20390088
[Presentation] Polycomb group proteins Ring1A/B are functionally linked to the coretranscriptional regulatory circuitry to maintain ES cell identity2008
- Author(s)
  Koseki H
- Organizer
  Shanghai Cancer Institute
- Place of Presentation
  Shanghai, China
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Histone H2A ubiquitinylation subdivides bivalent genes into PRC1-dependent and -independent domains in ES cells2008
- Author(s)
  古関明彦
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会、合同大会
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Mouse development : embryogenesis2008
- Author(s)
  Koseki H
- Organizer
  EMBO Practical Course on Anatomy and Embryology of the Mouse
- Place of Presentation
  Zagreb, Croatia
- Year and Date
  2008-09-06
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] Polycomb group proteins Ring1A/B are functionally linked to the coretranscriptional regulatory circuitry to maintain ES cell identity2008
- Author(s)
  古関明彦
- Organizer
  Shanghai Cancer Institute
- Place of Presentation
  中国、上海
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PLANNED-20062014
[Presentation] 精子形成過程におけるポリコームScmh1の機能解析2007
- Author(s)
  高田幸、古関明彦
- Organizer
  第40回日本発生生物学会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-18051019
[Presentation] Np95/UHRF1を介したエピジェネチック制御メカニズム
- Author(s)
  古関明彦
- Organizer
  福島医学会学術研究集会シンポジウム
- Place of Presentation
  福島
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] ポリコム群抑制ドメイン形成メカニズム
- Author(s)
  古関明彦
- Organizer
  国立遺伝学研究所研究会2012/2012 Research Conference of National Institute of Genetics
- Place of Presentation
  静岡
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] ポリコム群の機能発現メカニズム
- Author(s)
  古関明彦
- Organizer
  第4回シグナルネットワーク研究会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Polycomb potentiates Meis2 activation in midbrain by mediating precursory interaction of promoter with tissue-specific enhancer
- Author(s)
  古関明彦
- Organizer
  RCAI-Michigan Joint Workshop
- Place of Presentation
  米国ミシガン州
- Invited
- Data Source
  KAKENHI-PROJECT-23249015
[Presentation] Mechanisms underlying Polycomb repression
- Author(s)
  古関明彦
- Organizer
  文部科学省新学術領域「細胞運命制御」
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-23249015

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Koseki Haruhiko 古関 明彦

KOSEKI Haruhiko 古関 明彦

古関 明彦 コセキ ハルヒコ

Research Projects

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機動性DNAエレメントとCpGアイランドの相互作用による表現型揺らぎのメカニズム解明Principal Investigator

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ポリコムによる分化と共役するゲノム高次構造制御の分子機構解明Principal Investigator

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Elucidation of the replication mechanism of repression domains by Polycomb groupPrincipal Investigator

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Towards understanding the role for DNMT1 to establish Polycomb-mediated gene silencingPrincipal Investigator

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The role of CpG dinucleotides to generate PcG-repressive genomic domainsPrincipal Investigator

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Epigenetic regulation of mammalian spermatogenesisPrincipal Investigator

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Dissecting molecular mechanisms mediated by Polycomb group proteins in maintenance and differentiation of ES cellsPrincipal Investigator

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Koseki Haruhiko 古関明彦

KOSEKI Haruhiko 古関明彦

古関明彦コセキハルヒコ