OHTSUKA Toshihisa 大塚稔久

Researcher Number	40401806
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2025: 山梨大学, 大学院総合研究部, 教授 2014 – 2016: 山梨大学, 総合研究部, 教授 2015: 山梨大学大学院, 総合研究部, 教授 2015: 山梨大学, 大学院総合研究部, 教授 2011 – 2013: 山梨大学, 医学工学総合研究部, 教授 … More 2009 – 2012: University of Yamanashi, 大学院・医学工学総合研究部, 教授 2008: University of Toyama, 大学院医学薬学研究部, 准教授 2007 – 2008: University of Toyama, 大学院・医学薬学研究部, 准教授 2007: University of Toyama, 大学院・医学薬学研究科, 准教授 2006: 富山大学, 大学院医学薬学研究部, 助教授 2005: 富山大学, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 46010:Neuroscience-general-related / Biological Sciences / Neurochemistry/Neuropharmacology / Medium-sized Section 51:Brain sciences and related fields / Medium-sized Section 46:Neuroscience and related fields / Complex systems / Neurochemistry/Neuropharmacology / Neurophysiology / General neuroscience / Neurochemistry/Neuropharmacology … More Except Principal Investigator … More Broad Section I / Basic Section 43030:Functional biochemistry-related / Basic Section 52020:Neurology-related / General internal medicine (including Psychosomatic medicine) Less
Keywords	Principal Investigator アクティブゾーン / CAST / シナプス / ELKS / リン酸化 / シナプス小胞 / 神経科学 / 神経伝達物質放出 / RIM1 / 神経伝達物質 … More / SAD / 有芯小胞 / 液-液相分離 / 分子細胞神経科学 / 神経伝達物質・受容体 / チャネル / 神経 / Bassoon / プロテオミクス / 近位依存性ビオチン標識 / 液―液相分離 / 光ツール / 光遺伝学 / ネグレクト / 近位依存性ビオチン標識法 / ビオチンリガーゼ / オキシトシン / CRF / 小脳 / 細胞極性 / AMPK / 細胞内情報伝達 / RIM / 活動電位 / 膜複合体 / カルシウムチャネル / ノックアウトマウス / 神経回路 … More Except Principal Investigator モデル動物 / 疾患修飾療法 / シヌクレイノパチー / α-synuclein (αS) / レヴィ小体 / パーキンソン病 / インスリン開口放出 / アクティゾーンタンパク質 / 2相性インスリン分泌 / 極性分泌 / セプチン / アクティブゾーンタンパク質 / ２相性インスリン分泌 / インスリン開口分泌 / パーキンソニズム / 認知症 / 神経変性 / バイオマーカー / 多発性硬化症 / 多系統萎縮症 / BSN遺伝子変異 / ノックインマウス / BSN proteinopathy / Bassoon / タウオパチー / パーキンソン症候群 / ウイルスベクター / 脳分子プロファイル / 脳画像データベース / ブレインバンク / 技術開発支援 / 研究リソース支援 / 若手研究者育成支援 / 技術開発 / 研究リソース / 研究集会 / 研究支援 / 脳科学 / 一酸化窒素 / NF-κB / HLA-DRB1 / 桂枝加朮附湯 / cDNAマイクロアレイ / 関節リウマチ / 転写因子 / 分子病態 / 証 / 漢方医学 Less

神経シナプスにおけるCAST/ELKS-神経膜制御ネットワークの解明と神経変性疾患への応用Principal Investigator
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Yamanashi
Elucidation of mechanism of propagation and aggregation of alpha-synuclein and development of disease-modifying therapies
- Principal Investigator
  
  服部信孝
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  Juntendo University
液―液相分離の分子操作による神経機能解析Principal Investigator
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  University of Yamanashi
Development of Optogenetic Tools for Manipulating Dense-Core Vesicle DynamicsPrincipal Investigator
- Principal Investigator
  
  Ohtsuka Toshihisa
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 46:Neuroscience and related fields
- Research Institution
  University of Yamanashi
アクティブゾーン分子複合体の動態制御機構と多様性の理解Principal Investigator
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Yamanashi
ネグレクト発症・回復の予兆検出によるプレシナプス数理モデルの構築Principal Investigator
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
２相性インスリン極性分泌機構とその破綻による糖尿病発症
- Principal Investigator
  
  今泉美佳
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kyorin University
Pathophysiological study of Bassoon proteinopathy
- Principal Investigator
  
  Yabe Ichiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Hokkaido University
シナプス伝達制御と中枢ー末梢機能連関から捉える意志動力学Principal Investigator
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  University of Yamanashi
Molecular and structural basis and modification mechanisms of the active zones regulating synaptic transmission efficiencyPrincipal Investigator
- Principal Investigator
  
  Ohtsuka Toshihisa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Yamanashi
プレシナプス分子の動作原理から捉える適応回路メカニズムPrincipal Investigator
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
CAST/ELKSの機能制御から捉える網膜シナプスのスクラップアンドビルドPrincipal Investigator
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
Molecular and cellular mechanisms of active zone structure and function by the CAST/ELKS protein familyPrincipal Investigator
- Principal Investigator
  
  OHTSUKA Toshihisa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  University of Yamanashi
Analysis of signal dynamics mediated by AMPK subfamily in synapse maturationPrincipal Investigator
- Principal Investigator
  
  OHTSUKA Toshihisa
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  University of Yamanashi
Visualization and molecular mechanisms underlying neural polarity protein SAD kinase-mediated phosphorylationPrincipal Investigator
- Principal Investigator
  
  OHTSUKA Toshihisa
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  University of Yamanashi
Elucidation of molecular mechanismsand physiologicalfunctions of presyanptic active zonesPrincipal Investigator
- Principal Investigator
  
  OHTSUKA Toshihisa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  University of Yamanashi
Comprehensive Brain Science Network
- Principal Investigator
  
  Kimura Minoru
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Center for Novel Science Initatives, National Institutes of Natural Sciences
ELKS/CASTファミリーによるシナプス伝達制御機構の分子メカニズムの解析Principal Investigator
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
  University of Toyama
カルシウムチャネルの局在と機能を制御する膜複合体の解析Principal Investigator
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
  University of Toyama
神経回路網の成熟過程におけるアクティブ・ゾーンの役割の解明Principal Investigator
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Toyama
プレシナプスカルシウムチャネルと細胞膜裏打ち蛋白質群の複合体の機能解析Principal Investigator
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Toyama
Phosphorylation mechanisms underlying the presynaptic active zone structure and functionPrincipal Investigator
- Principal Investigator
  
  OHTSUKA Toshihisa
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  University of Toyama
分子病態検査学的手法による漢方医学診断(証)の解明
- Principal Investigator
  
  仁井見英樹, 山崎有佳
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  University of Toyama

[Book] Presynaptic Terminals2015
- Author(s)
  Ohtsuka, T.
- Total Pages
  15
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-25640009
[Book] Presynaptic Terminals2015
- Author(s)
  Ohtsuka, T.
- Total Pages
  15
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-15H04272
[Book] BRAIN & NERVE2011
- Author(s)
  大塚稔久
- Total Pages
  8
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22300120
[Book] Brain & Nerve2011
- Author(s)
  大塚稔久
- Total Pages
  8
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-23650188
[Journal Article] A light-controlled phospholipase C for imaging of lipid dynamics and controlling neural plasticity2024
- Author(s)
  Kim Yeon-Jeong、Tohyama Suguru、Nagashima Takashi、Nagase Masashi、Hida Yamato、Hamada Shun、Watabe Ayako M.、Ohtsuka Toshihisa
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 31 Issue: 7 Pages: 1-13
- DOI
  10.1016/j.chembiol.2024.03.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07986, KAKENHI-PROJECT-22K19356, KAKENHI-PROJECT-21K16374, KAKENHI-PROJECT-23K23980, KAKENHI-PROJECT-23K24799
[Journal Article] All-optical presynaptic plasticity induction by photoactivated adenylyl cyclase targeted to axon terminals2024
- Author(s)
  Nagase Masashi、Nagashima Takashi、Hamada Shun、Morishima Mieko、Tohyama Suguru、Arima-Yoshida Fumiko、Hiyoshi Kanae、Hirano Tomoha、Ohtsuka Toshihisa、Watabe Ayako M.
- Journal Title
  
  Cell Reports Methods
  
  Volume: 4 Issue: 4 Pages: 100740-100740
- DOI
  10.1016/j.crmeth.2024.100740
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06005, KAKENHI-PROJECT-21K07265, KAKENHI-PROJECT-22K19356, KAKENHI-PROJECT-21K16374, KAKENHI-PROJECT-23K23980, KAKENHI-PROJECT-23K24799
[Journal Article] A novel technique for large-fragment knock-in animal production without ex vivo handling of zygotes.2023
- Author(s)
  Abe M, NakatsukasaE, Natsume R, Hamada S, Sakimura K, Watabe AM, Ohtsuka, T.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 2245-2245
- DOI
  10.1038/s41598-023-29468-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19356, KAKENHI-PROJECT-18KK0458, KAKENHI-PUBLICLY-21H00192, KAKENHI-PROJECT-23K23980, KAKENHI-PROJECT-22H04922
[Journal Article] Experience-dependent changes in affective valence of taste in male mice2023
- Author(s)
  Hamada Shun、Mikami Kaori、Ueda Shuhei、Nagase Masashi、Nagashima Takashi、Yamamoto Mikiyasu、Bito Haruhiko、Takemoto-Kimura Sayaka、Ohtsuka Toshihisa、Watabe Ayako M.
- Journal Title
  
  Molecular Brain
  
  Volume: 16 Issue: 1 Pages: 28-28
- DOI
  10.1186/s13041-023-01017-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06483, KAKENHI-PROJECT-22K19356, KAKENHI-PROJECT-21K16374, KAKENHI-PROJECT-20H03855, KAKENHI-PROJECT-20K15936, KAKENHI-PUBLICLY-21H00192, KAKENHI-PROJECT-23K23980, KAKENHI-PLANNED-21H05091, KAKENHI-PROJECT-22H04922
[Journal Article] Critical Role of the Presynaptic Protein CAST in Maintaining the Photoreceptor Ribbon Synapse Triad2023
- Author(s)
  Hagiwara Akari、Mizutani Ayako、Kawamura Saki、Abe Manabu、Hida Yamato、Sakimura Kenji、Ohtsuka Toshihisa
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 8 Pages: 7251-7251
- DOI
  10.3390/ijms24087251
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09769, KAKENHI-PROJECT-22K19356, KAKENHI-PROJECT-23K23980
[Journal Article] Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.2022
- Author(s)
  Cao Y., Fajardo D., Guerrero-Given D., Samuel AM., Ohtsuka T., Boye SE., Kamasawa N., Martemyanov KA.
- Journal Title
  
  Current Biology
  
  Volume: 32 Issue: 22 Pages: 4783-4796
- DOI
  10.1016/j.cub.2022.09.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19356, KAKENHI-PUBLICLY-21H00192, KAKENHI-PROJECT-23K23980
[Journal Article] Ubap1 knock-in mice reproduced the phenotype of SPG802022
- Author(s)
  Shimozono K, Nan H, Takiyama Y, et al.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 67 Issue: 12 Pages: 679-686
- DOI
  10.1038/s10038-022-01073-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07456, KAKENHI-PROJECT-22K09637, KAKENHI-PROJECT-22K19356, KAKENHI-PROJECT-19K16040, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786, KAKENHI-PROJECT-20K08902, KAKENHI-PROJECT-21K19309, KAKENHI-PUBLICLY-21H00192, KAKENHI-PROJECT-23K23980
[Journal Article] Novel SLC9A6 Variation in Female Carriers With Intellectual Disability and Atypical Parkinsonism.2022
- Author(s)
  Nan, H., Kim, YJ., Tsuchiya, M., Ishida, A., Haro, H., Hiraide, M., Ohtsuka, T., Takiyama, Y.
- Journal Title
  
  Neurology Genetics
  
  Volume: 8 Issue: 1
- DOI
  10.1212/nxg.0000000000000651
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19356, KAKENHI-PROJECT-20K08902, KAKENHI-PUBLICLY-21H00192, KAKENHI-PROJECT-23K23980
[Journal Article] An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping2021
- Author(s)
  Hamada Shun、Nagase Masashi、Yoshizawa Tomohiko、Hagiwara Akari、Isomura Yoshikazu、Watabe Ayako M.、Ohtsuka Toshihisa
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1-11
- DOI
  10.1038/s42003-021-01977-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09769, KAKENHI-PROJECT-20K15936, KAKENHI-PUBLICLY-19H04758, KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324, KAKENHI-PROJECT-19K16299, KAKENHI-PUBLICLY-20H05053, KAKENHI-PROJECT-19H03342, KAKENHI-PROJECT-19H04062, KAKENHI-PROJECT-20H03855, KAKENHI-PROJECT-21K18564, KAKENHI-PROJECT-16H06276
[Journal Article] Development of an L-type Ca 2+ channel-dependent Ca 2+ transient during the radial migration of cortical excitatory neurons2020
- Author(s)
  Horigane S, Hamada S, Kamijo S, Yamada H, Yamasaki M, Watanabe M, Bito H, Ohtsuka T, Takemoto-Kimura S
- Journal Title
  
  Neurosci Res
  
  Volume: S0168-0102(20)30391-6 Pages: 30391-6
- DOI
  10.1016/j.neures.2020.06.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16490, KAKENHI-PLANNED-17H06312, KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H01007, KAKENHI-PROJECT-19H03324, KAKENHI-PROJECT-20H03410
[Journal Article] RFC1 repeat expansion in Japanese patients with late-onset cerebellar ataxia2020
- Author(s)
  Tsuchiya Mai、Nan Haitian、Koh Kishin、Ichinose Yuta、Gao Lihua、Shimozono Keisuke、Hata Takanori、Kim Yeon-Jeong、Ohtsuka Toshihisa、Cortese Andrea、Takiyama Yoshihisa
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 65 Issue: 12 Pages: 1143-1147
- DOI
  10.1038/s10038-020-0807-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324, KAKENHI-PROJECT-18K07495
[Journal Article] Impaired experience-dependent maternal care in presynaptic active zone protein CAST-deficient dams2020
- Author(s)
  Hagiwara, A., Sugiyama, N., Ohtsuka, T.*
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5238-5238
- DOI
  10.1038/s41598-020-62072-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324
[Journal Article] Presynaptic development is controlled by the core active zone proteins CAST/ELKS.2020
- Author(s)
  Radulovic, T., Dong, W., Goral, R., Thomas, C., Veeraraghavan, P., Montesinos, M., Guerrero-Given, D., Goff, K., Luebbert, M., Kamasawa, N., Ohtsuka, T., Young, S.M.*
- Journal Title
  
  J. Physiol.
  
  Volume: in press Issue: 12 Pages: 2431-2452
- DOI
  10.1113/jp279736
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324
[Journal Article] CAST/ELKS in the mouse forebrain causes high mortality of newborn pups.2020
- Author(s)
  Hagiwara, A., Hamada, S., Hida, Y., Ohtsuka, T.*
- Journal Title
  
  Molecular Brain
  
  Volume: 13 Issue: 1 Pages: 13-13
- DOI
  10.1186/s13041-020-0557-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324
[Journal Article] Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain2020
- Author(s)
  Miyata Tomoaki、Kikuchi Keietsu、Ihara Daisuke、Kaito Maki、Ishibashi Yuta、Hakamata Tomoyuki、Yamada Tetsuya、Ishikawa Mitsuru、Mizukoshi Miho、Shoji Shizuku、Fukuchi Mamoru、Tsuda Masaaki、Hida Yamato、Ohtsuka Toshihisa、Kaneda Marisa、Tabuchi Akiko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 528 Issue: 2 Pages: 322-329
- DOI
  10.1016/j.bbrc.2020.05.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324
[Journal Article] VPS13D-related disorders presenting as a pure and complicated form of hereditary spastic paraplegia2020
- Author(s)
  Koh K, Ishiura H, Shimazaki H, Tsutsumiuchi M, Ichinose Y, Nan H, Hamada S, Ohtsuka T, Tsuji S, Takiyama Y
- Journal Title
  
  Mol Genet Genomic Med
  
  Volume: 8 Issue: 3
- DOI
  10.1002/mgg3.1108
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07495, KAKENHI-PROJECT-19K16910, KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324, KAKENHI-PROJECT-16H06279
[Journal Article] Prickle2 and Igsf9b Coordinately Regulate the Cytoarchitecture of the Axon Initial Segment2020
- Author(s)
  Chowdhury Md. Imrul Hasan、Nishioka Tomoki、Mishima Noriko、Ohtsuka Toshihisa、Kaibuchi Kozo、Tsuboi Daisuke
- Journal Title
  
  Cell Structure and Function
  
  Volume: 45 Issue: 2 Pages: 143-154
- DOI
  10.1247/csf.20028
- NAID
  130007894945
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05014, KAKENHI-PUBLICLY-19H05209, KAKENHI-PROJECT-17H01380, KAKENHI-PROJECT-19H03324
[Journal Article] ELKS/Voltage-dependent Ca2+ channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β-Cells.2019
- Author(s)
  Ohara-Imaizumi, M., Aoyagi, K., Yamauchi, H., Yoshida, M., Mori, M.X., Hida, Y., Tran, H.N., Ohkura, M., Abe, M., Akimoto, Y., Nakamichi, Y., Nishiwaki, C., Kawakami, H., Hara, K., Sakimura, K., Nagamatsu, S., Mori, Y., Nakai, J., Kakei, M., and Ohtsuka, T.
- Journal Title
  
  Cell Reports
  
  Volume: 26 Issue: 5 Pages: 1213-1226
- DOI
  10.1016/j.celrep.2018.12.106
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08547, KAKENHI-PROJECT-17K09845, KAKENHI-PROJECT-18K08525, KAKENHI-PLANNED-16H06536, KAKENHI-PUBLICLY-17H05560, KAKENHI-PUBLICLY-17H05741, KAKENHI-PROJECT-16H05140, KAKENHI-PROJECT-15K09396, KAKENHI-PROJECT-16K19545, KAKENHI-PROJECT-17K01972, KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324
[Journal Article] Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells2019
- Author(s)
  Ohara-Imaizumi Mica、Aoyagi Kyota、Ohtsuka Toshihisa
- Journal Title
  
  Molecular Metabolism
  
  Volume: 27 Pages: 1213-1226
- DOI
  10.1016/j.molmet.2019.06.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324, KAKENHI-PROJECT-17K08547, KAKENHI-PROJECT-17K09845
[Journal Article] Vangl2 interaction plays a role in the proteasomal degradation of Prickle22019
- Author(s)
  Nagaoka Tadahiro、Furuse Mikio、Ohtsuka Toshihisa、Tsuchida Kunihiro、Kishi Masashi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 2912-2912
- DOI
  10.1038/s41598-019-39642-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05560, KAKENHI-PUBLICLY-17H05741, KAKENHI-PROJECT-16K08599, KAKENHI-PROJECT-17K15551, KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324
[Journal Article] UBAP1 mutations cause juvenile-onset hereditary spastic paraplegias (SPG80) and impair UBAP1 targeting to endosomes2019
- Author(s)
  Nan H, Ichinose Y, Tanaka M, Koh K, Ishiura H, Mitsui J, Mizukami H, Morimoto M, Hamada S, Ohtsuka T, Tsuji S, Takiyama Y
- Journal Title
  
  J Hum Genet
  
  Volume: 64 Issue: 11 Pages: 1055-1065
- DOI
  10.1038/s10038-019-0670-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07495, KAKENHI-PROJECT-19K16910, KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324
[Journal Article] Neuroimaging, genetic, and enzymatic study in a Japanese family with a GBA gross deletion.2019
- Author(s)
  Ichinose Y, Ishiura H, Tanaka M, Yoshimura J, Doi K, Umeda T, Yamauchi H, Tsuchiya M, Koh K, Yamashiro N, Mitsui J, Goto J, Onishi H, Ohtsuka T, Shindo K, Morishita S, Tsuji S, Takiyama Y.
- Journal Title
  
  Parkinsonism Relat Disord.
  
  Volume: - Pages: 57-63
- DOI
  10.1016/j.parkreldis.2018.11.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17772, KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324
[Journal Article] CAST: Its molecular structure and phosphorylation-dependent regulation of presynaptic plasticity2018
- Author(s)
  Hamada Shun、Ohtsuka Toshihisa
- Journal Title
  
  Neurosci. Res.
  
  Volume: 127 Pages: 25-32
- DOI
  10.1016/j.neures.2017.12.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05560, KAKENHI-PUBLICLY-17H05741, KAKENHI-PROJECT-15H04272, KAKENHI-PROJECT-16K16647
[Journal Article] Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology2018
- Author(s)
  Kaneda Marisa、Sakagami Hiroyuki、Hida Yamato、Ohtsuka Toshihisa、Satou Natsumi、Ishibashi Yuta、Fukuchi Mamoru、Krysiak Anna、Ishikawa Mitsuru、Ihara Daisuke、Kalita Katarzyna、Tabuchi Akiko
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 727-727
- DOI
  10.1038/s41598-017-18905-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05560, KAKENHI-PUBLICLY-17H05741, KAKENHI-PROJECT-15H04272
[Journal Article] Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance2018
- Author(s)
  Hagiwara Akari、Kitahara Yosuke、Grabner Chad Paul、Vogl Christian、Abe Manabu、Kitta Ryo、Ohta Keisuke、Nakamura Keiichiro、Sakimura Kenji、Moser Tobias、Nishi Akinori、Ohtsuka Toshihisa
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 217 Issue: 11 Pages: 3993-4006
- DOI
  10.1083/jcb.201704076
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01972, KAKENHI-PUBLICLY-17H05560, KAKENHI-PUBLICLY-17H05741, KAKENHI-PROJECT-16H05135, KAKENHI-PROJECT-16K00934
[Journal Article] Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome2018
- Author(s)
  Yabe I, Yaguchi H, Kato Y, Miki Y, Takahashi H, Tanikawa S, Shirai S, Takahashi I, Kimura M, Hama Y, Matsushima M, Fujioka S, Kano T, Watanabe M, Nakagawa S, Kunieda Y, Ikeda Y, Hasegawa M, Nishihara H, Ohtsuka T, Tanaka S, Tsuboi Y, Hatakeyama S, Wakabayashi K, Sasaki H
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 819-819
- DOI
  10.1038/s41598-018-19198-0
- NAID
  120006377499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09663, KAKENHI-PROJECT-16K09665, KAKENHI-PROJECT-17K19506, KAKENHI-PUBLICLY-17H05560, KAKENHI-PUBLICLY-17H05741, KAKENHI-PUBLICLY-17H05989, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-15H04272, KAKENHI-PROJECT-15H04701, KAKENHI-PROJECT-16H06221, KAKENHI-PROJECT-18H02378, KAKENHI-PROJECT-17K19578
[Journal Article] CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse2018
- Author(s)
  Dong Wei、Radulovic Tamara、Goral R. Oliver、Thomas Connon、Suarez Montesinos Monica、Guerrero-Given Debbie、Hagiwara Akari、Putzke Travis、Hida Yamato、Abe Manabu、Sakimura Kenji、Kamasawa Naomi、Ohtsuka Toshihisa、Young Samuel M.
- Journal Title
  
  Cell Reports
  
  Volume: 24 Issue: 2 Pages: 284-293.e6
- DOI
  10.1016/j.celrep.2018.06.024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01972, KAKENHI-PUBLICLY-17H05560, KAKENHI-PUBLICLY-17H05741
[Journal Article] A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.2017
- Author(s)
  Minegishi, K., Hashimoto, M., Ajima, R., Takaoka, K., Shinohara, K., Ikawa, Y., Nishimura, H., McMahon, AP., Willert, K., Okada, Y., Sasaki, H., Shi, D., Fujimori, T., Ohtsuka, T., Igarashi, Y., Yamaguchi, TP., Shimono, A., Shiratori, H., Hamada, H.
- Journal Title
  
  Dev Cell.
  
  Volume: 40 Issue: 5 Pages: 439-452
- DOI
  10.1016/j.devcel.2017.02.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01220, KAKENHI-PUBLICLY-15H01511, KAKENHI-ORGANIZER-24113001, KAKENHI-PROJECT-15H04272, KAKENHI-PROJECT-25291054, KAKENHI-PROJECT-26440124, KAKENHI-PROJECT-17H01435
[Journal Article] The Auxiliary calcium channel subunitα2δ4 is required for axonal elaboration, synaptic transmission, and wiring of rod photoreceptors2017
- Author(s)
  Wang, Y., Fehlhaber, K.E., Sarria, I., Cao, Y., Ingram, N.T., Guerrero-Given, D., Throesch, B., Baldwin, K., Kamasawa, N., Ohtsuka, T., Sampath, A.P., Martemyanov, K.A.
- Journal Title
  
  Neuron
  
  Volume: 93 Issue: 6 Pages: 1359-1374
- DOI
  10.1016/j.neuron.2017.02.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04272
[Journal Article] SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression.2016
- Author(s)
  Mochida, S.*, Hida, Y., Tanifuji, S., Hagiwara, A., Hamada, S., Abe, M., Huan, M., Yasumura, M., Kitajima, I., Sakimura, K., Ohtsuka, T*.
- Journal Title
  
  Cell Reports
  
  Volume: 16 Issue: 11 Pages: 2901-2913
- DOI
  10.1016/j.celrep.2016.08.020
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04272, KAKENHI-PROJECT-16H04650, KAKENHI-PROJECT-25290025, KAKENHI-PROJECT-26350979, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-25000015
[Journal Article] SAD-B Kinase regulates presynaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory.2016
- Author(s)
  Watabe, A.M., Nagase, M., Hagiwara, A., Hida, Y., Tsuji, M., Ochiai, T., Kato, F., Ohtsuka, T.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 136: Issue: 1 Pages: 36-47
- DOI
  10.1111/jnc.13379
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-26115523, KAKENHI-PROJECT-15H04272, KAKENHI-PROJECT-25293136, KAKENHI-PUBLICLY-15H01295, KAKENHI-PROJECT-25430015, KAKENHI-PROJECT-16K07004
[Journal Article] Dopamine synapse is a neuroligin-2–mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures.2016
- Author(s)
  Uchigashima, M., Ohtsuka, T., Kobayashi, K., Watanabe, M.
- Journal Title
  
  PNAS
  
  Volume: - Issue: 15 Pages: 4206-4211
- DOI
  10.1073/pnas.1514074113
- NAID
  120005849913
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04272, KAKENHI-PLANNED-26112002, KAKENHI-PROJECT-24220007
[Journal Article] The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus.2016
- Author(s)
  Kobayashi S, Hida Y, Ishizaki H, Inoue E, Tanaka-Okamoto M, Yamasaki M, Miyazaki T, Masahiro F, Kitajima I, Takai Y, Watanabe M, Ohtsuka T, Manabe T
- Journal Title
  
  Eur J Neurosci.
  
  Volume: 44 Issue: 5 Pages: 2272-2284
- DOI
  10.1111/ejn.13331
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-15H04272, KAKENHI-PROJECT-26460250, KAKENHI-PROJECT-26460251, KAKENHI-PROJECT-15K14309, KAKENHI-PROJECT-15K08612
[Journal Article] The planar cell polarity protein Vangl2 bidirectionally regulates dendritic branching in cultured hippocampal neurons.2014
- Author(s)
  Hagiwara, A., Yasumura, M., Hida, Y., Inoue, E., Ohtsuka, T.
- Journal Title
  
  Mol. Brain
  
  Volume: 7 Issue: 1 Pages: 79-79
- DOI
  10.1186/s13041-014-0079-5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25640009
[Journal Article] the planner cell polarity protein, is complexed with postsynaptic density protein PSD-952013
- Author(s)
  Yoshioka, T., Hagiwara, A., Hida, Y., Ohtsuka, T. Vangl2
- Journal Title
  
  FEBS Lett
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300120
[Journal Article] CAST: functional scaffold for the integrity of the presynaptic active2013
- Author(s)
  Ohtsuka, T.
- Journal Title
  
  Neurosci. Res.
  
  Volume: in press Issue: 1-2 Pages: 10-15
- DOI
  10.1016/j.neures.2013.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300120, KAKENHI-PROJECT-23650188, KAKENHI-PROJECT-25640009
[Journal Article] Identification, expression and characterization of rat isoforms of the serum response factor (SRF) coactivator MKL1.2013
- Author(s)
  Ishikawa, M., Shiota, J., Ishibashi, Y., Hakamata, T., Shoji, S., Fukuchi, M., Tsuda, M., Shirao, T., Sekino, Y., Ohtsuka, T., Baraban, J.M., Tabuchi, A.
- Journal Title
  
  FEBS Open Bio.
  
  Volume: 3 Issue: 1 Pages: 387-393
- DOI
  10.1016/j.fob.2013.09.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640009
[Journal Article] CAST: functional scaffold for the integrity of the presynaptic active zone2013
- Author(s)
  Ohtsuka, T
- Journal Title
  
  Neurosci. Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300120
[Journal Article] functional scaffold for the integrity of the presynaptic active zone2013
- Author(s)
  Ohtsuka, T. CAST
- Journal Title
  
  Neurosci. Res
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650188
[Journal Article] Physical and Functional Interaction of the Active Zone Protein CAST/ERC2 and the ss-subunit of the Voltage-dependent Ca^Channel2012
- Author(s)
  Kiyonaka, S., Nakajima, H., Takada, Y., Hida, Y., Yoshioka, T., Hagiwara, A., Kitajima, I., Mori, Y., Ohtsuka, T
- Journal Title
  
  J. Biochem
  
  Volume: 152 Pages: 149-159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650188
[Journal Article] Physical and Functional Interaction of the Active Zone Protein CAST/ERC2 and the β-subunit of the Voltage-dependent Ca2+Channel2012
- Author(s)
  Kiyonaka, S., Nakajima, H., Takada, Y., Hida, Y., Yoshioka, T., Hagiwara, A., Kitajima, I., Mori, Y., Ohtsuka, T
- Journal Title
  
  J. Biochem
  
  Volume: 152 Pages: 149-159
- NAID
  10031166124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300120
[Journal Article] Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing2012
- Author(s)
  tom Dieck, S., Specht, D., Strenzke, N., Hida, Y., Krishnamoorthy, V., Inoue, E., Ishizaki, H., Tanaka-Okamoto, M., Miyoshi, J., Hagiwara, A., Brandstatter, JH., Gollisch, T., Ohtsuka, T. *, Moser, T*
- Journal Title
  
  J. Neurosci
  
  Volume: 32 Pages: 12192-12203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650188
[Journal Article] Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing2012
- Author(s)
  tom Dieck, S., Specht, D., Strenzke, N., Hida, Y., Krishnamoorthy, V., Inoue, E., Ishizaki, H., Tanaka-Okamoto, M., Miyoshi, J., Hagiwara, A., Brandstatter, JH., Gollisch, T., Ohtsuka, T.*, Moser, T*
- Journal Title
  
  J. Neurosci
  
  Volume: 32 Pages: 12192-12203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300120
[Journal Article] Distribution of serine/threonine kinase SAD-B in mouse peripheral nerve synapse2011
- Author(s)
  Hagiwara, A., Harada, K., Hida, Y., Kitajima, I., Ohtsuka, T
- Journal Title
  
  NeuroReport
  
  Volume: 22 Pages: 319-325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300120
[Journal Article] Prickle2 is localized in the postsynaptic density and interacts with PSD-95 and NMDA receptors in the brain2011
- Author(s)
  Hida, Y., Fukaya, M., Hagiwara, A., Deguchi-Tawarada, M., Yoshioka, T., Kitajima, I., Inoue, E., Watanabe, M., Ohtsuka, T
- Journal Title
  
  J. Biochem
  
  Volume: 149 Pages: 693-700
- NAID
  10030585839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300120
[Journal Article] CAST and ELKS Proteins: Structural and Functional Determinants of the Presynaptic Active Zone2010
- Author(s)
  Hida, Y., Ohtsuka, T
- Journal Title
  
  J. Biochem
  
  Volume: 148 Pages: 131-137
- NAID
  10027877396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300120
[Journal Article] Reduced expression of the ATRXgene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice2010
- Author(s)
  Nogami, T., Beppu, H., Tokoro, T., Moriguchi, S., Shioda, N., Fukunaga, K., Ohtsuka, T., Ishii, I., Sasahara, M., Shimada, Y., Nishijo, H., Li, E., Kitajima, I
- Journal Title
  
  Hippocampus
  
  Volume: 21 Pages: 678-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300120
[Journal Article] Rab6 regulates transport and targeting of exocytotic carriers2007
- Author(s)
  Grigoriev, I., Splinter, D., Keijzer, N., Wulf, P.,Demmers, J., Ohtsuka, T., Modesti, M., Maly, I., Grosveld, F., Hoogenraad, C. C., and Akhmanova, A.
- Journal Title
  
  Dev. Cell 13
  
  Pages: 305-314
- Data Source
  KAKENHI-PROJECT-18680032
[Journal Article] SCRAPPER-Dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release2007
- Author(s)
  Yao, I., Takagi, H., Ageta, H, Kahyo, T, Sato, S., Hatanaka, K., Fukuda, Y., Chiba, T., Morone, N., Yuasa, S., Inokuchi, K., Ohtsuka, T., MacGregor, G.R., Tanaka, K., Setou, M.
- Journal Title
  
  Cell 130
  
  Pages: 943-957
- Data Source
  KAKENHI-PROJECT-18680032
[Journal Article] Localization of the Active Zone Proteins CAST, ELKS, and Piccolo at Neuromuscular Junctions2007
- Author(s)
  Tokoro, T., Higa Onaga, S., Deguchi-Tawarada, M., Inoue, E., Kitajima, I., and Ohtsuka, T.
- Journal Title
  
  NeuroReport 18
  
  Pages: 313-316
- Data Source
  KAKENHI-PROJECT-18680032
[Journal Article] Interaction between Munc13-1 and RIM is Critical for Glucagon-like Peptide-1-mediated Rescue of Exocytotic Defects in Munc13-1-deficient pancreatic {beta}-cells2007
- Author(s)
  Kwan, E., Xie, L.Sheu, L.., Ohtsuka, T., and Gaisano, H.Y.
- Journal Title
  
  Diabetes 56
  
  Pages: 2579-2588
- Data Source
  KAKENHI-PROJECT-18680032
[Journal Article] The active zone protein CAST directly associates with Ligand-of-Numb protein X.2007
- Author(s)
  Higa S, Tokoro T, Inoue E, Kitajima I, Ohtsuka T
- Journal Title
  
  Biochem Biophys Res Commun. 354 (3)
  
  Pages: 686-692
- Data Source
  KAKENHI-PROJECT-17659201
[Journal Article] The Active Zone Protein CAST Directly Associates with Ligand-of-Numb Protein X2007
- Author(s)
  Higa Onaga, S., Tokoro, T., Inoue, E., Kitajima, I., and Ohtsuka, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 354
  
  Pages: 686-692
- Data Source
  KAKENHI-PROJECT-18680032
[Journal Article] Three-dimensional architecture of presynaptic terminal cytomatrix2007
- Author(s)
  Siksou, L.., Rostaing, P., Lechaire, J-P., Boudier, T., Ohtsuka, T., Fejtov , A., Kao, H-T., Greengard, P., Gundelfinger, E.D., Triller, A., and Marty, S.
- Journal Title
  
  J. Neurosci. 27
  
  Pages: 6868-6877
- Data Source
  KAKENHI-PROJECT-18680032
[Journal Article] CLASPs attach microtube plus ends to the cell cortex through a complex with LL5β2006
- Author(s)
  Lansgergen, G., Grigoriev, I., Minori-Kiyosue, Y., Ohtsuka, T., Higa, S., Kitajima, I., Demmers, J., Galjart, N., Houtsmuller, A.B., Grosveld, F. and Akhmanova, A.
- Journal Title
  
  Dev. Cell 11
  
  Pages: 21-32
- Data Source
  KAKENHI-PROJECT-18680032
[Journal Article] Active Zone Protein CAST is a Component of Conventional and Ribbon Synapses in Mouse Retina2006
- Author(s)
  Deguchi-Tawarada, M., Inoue, E., Takao-Rikitsu, E., Inoue, M., Kitajima,I., Ohtsuka, T., and Takai, Y.
- Journal Title
  
  J. Comp. Neurol. 495
  
  Pages: 480-496
- Data Source
  KAKENHI-PROJECT-18680032
[Journal Article] ELKS, a protein structurally related to the active zone protein CAST, regulates Ca2+-dependent exocytosis from PC12 cells2006
- Author(s)
  Inoue, E, Deguchi-Tawarada, M., Takao-Rikitsu, E.., Inoue, M., Kitajima, I., Ohtsuka, T., and Takai, Y.
- Journal Title
  
  Genes Cells 11
  
  Pages: 659-672
- Data Source
  KAKENHI-PROJECT-18680032
[Journal Article] SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release2006
- Author(s)
  Inoue, E., Mochida, S., Takagi, H., Higa, S., Deguchi-Tawarada, M., Takao-Rikitsu, E., Inoue, M., Yao, I., Takeuchi, K., Kitajima, I., Setou, M., Ohtsuka, T., and Takai, Y.
- Journal Title
  
  Neuron 50
  
  Pages: 261-275
- Data Source
  KAKENHI-PROJECT-18680032
[Presentation] Optogenetic Control of Basolateral Amygdala Plasticity and Fear Memory Formation via Engineered Phospholipase C2024
- Author(s)
  Yeon-Jeong Kim, Suguru Tohyama, Takashi Nagashima, Masashi Nagase, Yamato Hida, Shun Hamada, Ayako M. Watabe and Toshihisa Ohtsuka
- Organizer
  Neuronal Circuits Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19356
[Presentation] Optogenetic Control of Basolateral Amygdala Plasticity and Fear Memory Formation via Engineered Phospholipase C2024
- Author(s)
  Yeon-Jeong Kim, Suguru Tohyama, Takashi Nagashima, Masashi Nagase, Yamato Hida, Shun Hamada, Ayako M. Watabe and Toshihisa Ohtsuka
- Organizer
  Neuronal Circuits Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23980
[Presentation] Optogenetic engineering of light-controlled phospholipase C: metabolic dynamics of phosphoinositide2023
- Author(s)
  Yeon-Jeong Kim, Shun Hamada, and Toshihisa Ohtsuka
- Organizer
  ゴードンリサーチカンファレンスMolecular and Cellular Biology of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19356
[Presentation] Optogenetic engineering of light-controlled phospholipase C: metabolic dynamics of phosphoinositide2023
- Author(s)
  Yeon-Jeong Kim, Shun Hamada, and Toshihisa Ohtsuka
- Organizer
  ゴードンリサーチカンファレンスMolecular and Cellular Biology of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23980
[Presentation] Live cell-imaging of CAST/ELKS-mediated liquid-liquid phase separation regulates protein complexes in presynaptic active zone2023
- Author(s)
  Kim Yeon-Jeong, Hida Y, Ohtsuka T.
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-22K19356
[Presentation] Depletion of LKB1 at cerebellar synapses causes progressive locomotion dysfunction linked to the reduced neuromuscular transmission.2023
- Author(s)
  Sota Sawada, Ryo Kozawa, Masataka Yamamoto, Yuhei Mizunoe, Ryo Goitsuka, Toshihisa Ohtsuka, Hiroshi Takemura, and Akari Hagiwara.
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K23980
[Presentation] The future of Japan brain initiatives: BRAIN/MINDS and BRAIN/MINDS Beyond2023
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  ヒューマンブレインプロジェクト(HBP)サミット
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19356
[Presentation] Depletion of LKB1 at cerebellar synapses causes progressive locomotion dysfunction linked to the reduced neuromuscular transmission.2023
- Author(s)
  Sota Sawada, Ryo Kozawa, Masataka Yamamoto, Yuhei Mizunoe, Ryo Goitsuka, Toshihisa Ohtsuka, Hiroshi Takemura, and Akari Hagiwara.
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-22K19356
[Presentation] The future of Japan brain initiatives: BRAIN/MINDS and BRAIN/MINDS Beyond2023
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  ヒューマンブレインプロジェクト(HBP)サミット
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23980
[Presentation] Live cell-imaging of CAST/ELKS-mediated liquid-liquid phase separation regulates protein complexes in presynaptic active zone2023
- Author(s)
  Kim Yeon-Jeong, Hida Y, Ohtsuka T.
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K23980
[Presentation] The future of Japan brain initiatives: BRAIN/MINDS and BRAIN/MINDS Beyond2023
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  ヒューマンブレインプロジェクト(HBP)サミット
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00192
[Presentation] Depletion of LKB1 in the cerebellar granule cells induces locomotor dysfunction in aged mice.2022
- Author(s)
  Mayu Kitamura, Akari Hagiwara, Shun Hamada, and Toshihisa Ohtsuka
- Organizer
  第４５回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23980
[Presentation] Depletion of LKB1 in the cerebellar granule cells induces locomotor dysfunction in aged mice.2022
- Author(s)
  Mayu Kitamura, Akari Hagiwara, Shun Hamada, and Toshihisa Ohtsuka
- Organizer
  第４５回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19356
[Presentation] Depletion of LKB1 in the cerebellar granule cells induces locomotor dysfunction in aged mice.2022
- Author(s)
  Mayu Kitamura, Akari Hagiwara, Shun Hamada, and Toshihisa Ohtsuka
- Organizer
  第４５回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00192
[Presentation] Morphological examination of the role of LKB1 in retinal horizontal cell remodeling using the AAV-based labeling system.2022
- Author(s)
  Saki Kawamura, Toshihisa Ohtsuka, Yamato Hida, Akari Hagiwara
- Organizer
  第４５回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19356
[Presentation] Morphological examination of the role of LKB1 in retinal horizontal cell remodeling using the AAV-based labeling system2022
- Author(s)
  Saki Kawamura, Toshihisa Ohtsuka, Yamato Hida, Akari Hagiwara
- Organizer
  第４５回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23980
[Presentation] Morphological examination of the role of LKB1 in retinal horizontal cell remodeling using the AAV-based labeling system2022
- Author(s)
  Saki Kawamura, Toshihisa Ohtsuka, Yamato Hida, Akari Hagiwara
- Organizer
  第４５回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00192
[Presentation] Role of CAST/ELKS in the active zone function via liquid-liquid phase separation2021
- Author(s)
  大塚稔久
- Organizer
  第44回日本神経科学大会（CJK第１回国際会議）
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00192
[Presentation] An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping2021
- Author(s)
  Shun Hamada, Masashi Nagase, Tomohiko Yoshizawa, Akari Hagiwara, Yoshikazu　Isomura, Ayako M. Watabe, and Toshihisa Ohtsuka
- Organizer
  第44回日本神経科学大会（CJK第１回国際会議）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03324
[Presentation] An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping2021
- Author(s)
  Shun Hamada, Masashi Nagase, Tomohiko Yoshizawa, Akari Hagiwara, Yoshikazu　Isomura, Ayako M. Watabe, and Toshihisa Ohtsuka
- Organizer
  第44回日本神経科学大会（CJK第１回国際会議）
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00192
[Presentation] Role of CAST/ELKS in the active zone function via liquid-liquid phase separation2021
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  第44回日本神経科学大会（CJK第１回国際会議）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03324
[Presentation] 光操作ツールの紹介2020
- Author(s)
  大塚稔久
- Organizer
  CREST「オプトバイオ」領域の第5回領域会議
- Invited
- Data Source
  KAKENHI-PROJECT-19H03324
[Presentation] 光操作ツールの紹介2020
- Author(s)
  大塚稔久
- Organizer
  CREST「オプトバイオ」領域の第5回領域会議
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05014
[Presentation] 前シナプスアクティブゾーン因子群のプロテオーム解析と液相分離2020
- Author(s)
  大塚稔久
- Organizer
  第93回日本生化学会シンポジウム「生体膜ダイナミクス:細胞レベルの制御機構から個体レベルの生理機能まで」
- Invited
- Data Source
  KAKENHI-PROJECT-19H03324
[Presentation] 前シナプスアクティブゾーン因子群のプロテオーム解析と液相分離2020
- Author(s)
  大塚稔久
- Organizer
  第93回日本生化学会シンポジウム「生体膜ダイナミクス:細胞レベルの制御機構から個体レベルの生理機能まで」
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05014
[Presentation] Neuropsychopharmacology of relaxin-32019
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  第６回アジア神経精神薬理学会大会（AsCNP2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03324
[Presentation] Neuropsychopharmacology of relaxin-32019
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  第６回アジア神経精神薬理学会大会（AsCNP2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05014
[Presentation] Integral system by CAST/ELKS protein family to regulate retinal photoreceptor development and maintenance.2018
- Author(s)
  Ohtsuka T.
- Organizer
  BRI International Symposium 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04272
[Presentation] Molecular Mechanisms of Presynaptic Transmission.2018
- Author(s)
  Ohtsuka T.
- Organizer
  The first international symposium for frontend brain science: University of Yamanashi 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04272
[Presentation] Integral system by CAST/ELKS protein family to regulate retinal photoreceptor development and maintenance.2018
- Author(s)
  Ohtsuka T.
- Organizer
  BRI International Symposium 2018.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05741
[Presentation] Integral system by the active zone proteins CAST and ELKS to control retinal synaptic transmission and photoreceptor remodeling.2018
- Author(s)
  Ohtsuka T.
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PUBLICLY-17H05741
[Presentation] Integral system by the active zone proteins CAST and ELKS to control retinal synaptic transmission and photoreceptor remodeling.2018
- Author(s)
  Ohtsuka T.
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PUBLICLY-17H05560
[Presentation] Molecular Mechanisms of Presynaptic Transmission.2018
- Author(s)
  Ohtsuka T.
- Organizer
  The first international symposium for frontend brain science: University of Yamanashi 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05741
[Presentation] Molecular structure and function of the presynaptic active zone.2018
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  A symposium in honor of Sumiko Mochida-Forefront of Neurotransmitter Release and Calcium Channel Signaling
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05741
[Presentation] Molecular Mechanisms of Presynaptic Transmission.2018
- Author(s)
  Ohtsuka T.
- Organizer
  The first international symposium for frontend brain science: University of Yamanashi 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05560
[Presentation] Integral system by CAST/ELKS protein family to regulate retinal photoreceptor development and maintenance.2018
- Author(s)
  Ohtsuka T.
- Organizer
  BRI International Symposium 2018.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05560
[Presentation] Molecular structure and function of the presynaptic active zone.2018
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  A symposium in honor of Sumiko Mochida-Forefront of Neurotransmitter Release and Calcium Channel Signaling
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05560
[Presentation] Integral system by the active zone proteins CAST and ELKS to control retinal synaptic transmission and photoreceptor remodeling.2018
- Author(s)
  Ohtsuka T.
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-15H04272
[Presentation] CAST Phosphorylation in Control of Short-term Plasticity at the presynaptic Active Zones.2017
- Author(s)
  大塚稔久
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PUBLICLY-17H05741
[Presentation] CAST Phosphorylation in Control of Short-term Plasticity at the presynaptic Active Zones.2017
- Author(s)
  Ohtsuka T.
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PUBLICLY-17H05560
[Presentation] CAST Phosphorylation in Control of Short-term Plasticity at the presynaptic Active Zones.2017
- Author(s)
  大塚稔久
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15H04272
[Presentation] Decoding short-term synaptic plasticity: implication of CAST phosphorylation in control of synaptic plasticity at the excitatory synapses2016
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  The 47th NIPS International Symposium “Decoding Synapses”
- Place of Presentation
  Okazaki Conference Center (OCC), Okazaki, Aichi
- Year and Date
  2016-10-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04272
[Presentation] Exploration of neural mechanism involved in the adequate2016
- Author(s)
  Hagiwara A., Sugiyama N., Ohtsuka T.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15H04272
[Presentation] 神経伝達物質の放出から捉える脳の高次機能とその破綻2015
- Author(s)
  大塚稔久
- Organizer
  第10回山梨脳・血管セミナー
- Place of Presentation
  甲府富士屋ホテル（山梨県甲府市）
- Year and Date
  2015-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-15H04272
[Presentation] 神経終末アクティブゾーンの分子構造基盤とその破綻　～構造分子解析から脳高次機能の解明へ向けて～2015
- Author(s)
  大塚稔久
- Organizer
  招待セミナー
- Place of Presentation
  東京医科歯科大学（東京都文京区）
- Year and Date
  2015-06-23
- Invited
- Data Source
  KAKENHI-PROJECT-15H04272
[Presentation] The active zone proteins CAST and ELKS regulate the structure and function of retinal ribbon synapses.2015
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  Ribbon Synapses Symposium
- Place of Presentation
  ゲッティンゲン（ドイツ）
- Year and Date
  2015-09-24
- Invited
- Data Source
  KAKENHI-PROJECT-15H04272
[Presentation] プレシナプス・キナーゼSAD-Bによるシナプス小胞ダイナミクスと可塑性制御の分子基盤2015
- Author(s)
  大塚稔久
- Organizer
  生理学研究所研究会「シナプス・神経ネットワークの機能ダイナミクス」
- Place of Presentation
  生理学研究所（愛知県岡崎市）
- Year and Date
  2015-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-15H04272
[Presentation] CAST and ELKS: molecular determinants for the presynaptic active zone2015
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  Invited seminar
- Place of Presentation
  マイアミ(アメリカ合衆国）
- Year and Date
  2015-06-03
- Invited
- Data Source
  KAKENHI-PROJECT-15H04272
[Presentation] 神経終末アクティブゾーンの分子構造基盤とその破綻～プレシナプスから精神神経疾患の発症機構を捉える～2014
- Author(s)
  大塚稔久
- Organizer
  東京都医学総合研究所　招待講演
- Place of Presentation
  東京都医学総合研究所(東京都）
- Year and Date
  2014-08-15
- Invited
- Data Source
  KAKENHI-PROJECT-25640009
[Presentation] 神経終末アクティブゾーンの分子構造基盤と生理機能～分子から精神神経疾患の病態解明へ向けて～2014
- Author(s)
  大塚稔久
- Organizer
  北里大学医学会招待学術講演会
- Place of Presentation
  北里大学（東京都）
- Year and Date
  2014-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-25640009
[Presentation] The presynaptic active zone molecular organization and physiological functions.2013
- Author(s)
  大塚稔久
- Organizer
  神経構造生物学合同研究会
- Place of Presentation
  生理学研究所（愛知県岡崎市）
- Data Source
  KAKENHI-PROJECT-25640009
[Presentation] CAST regulates the structure and function of presynaptic active zones2013
- Author(s)
  大塚稔久
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-25640009
[Presentation] CAST and vesicle cycling at the ribbon synapses2013
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  Ribbon Synapses Symposium
- Place of Presentation
  Max-Planck-Institute for Experimental Medicine Goettingen, Germany
- Invited
- Data Source
  KAKENHI-PROJECT-25640009
[Presentation] CAST Phosphorylation Mediates Short-term Synaptic Depression2013
- Author(s)
  大塚稔久
- Organizer
  Neuro2013
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Data Source
  KAKENHI-PROJECT-25640009
[Presentation] 翻訳後修飾によるプレシナプス・アクティブゾーンの機能制御2012
- Author(s)
  大塚稔久
- Organizer
  生理学研究所シナプス研究会「神経シナプス伝達の時空間ダイナミクス」
- Place of Presentation
  自然科学研究機構（愛知県岡崎市）
- Invited
- Data Source
  KAKENHI-PROJECT-23650188
[Presentation] Structure and function of the presynaptic active zone2012
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  24年度国際シナプス研究会
- Place of Presentation
  岡崎
- Data Source
  KAKENHI-PROJECT-23650188
[Presentation] 翻訳後修飾によるプレシナプス・アクティブゾーンの機能制御2012
- Author(s)
  大塚稔久
- Organizer
  生理学研究所シナプス研究会「神経シナプス伝達の時空間ダイナミクス」
- Place of Presentation
  自然科学研究機構（愛知県岡崎市）
- Invited
- Data Source
  KAKENHI-PROJECT-22300120
[Presentation] 翻訳後修飾によるプレシナプス・アクティブゾーンの機能制御2012
- Author(s)
  大塚稔久
- Organizer
  生理学研究所シナプス研究会「神経シナプス伝達の時空間ダイナミクス」
- Place of Presentation
  愛知県岡崎市
- Data Source
  KAKENHI-PROJECT-22300120
[Presentation] Structure and function of the presynaptic active zone2012
- Author(s)
  Ohtsuka Toshihisa
- Organizer
  24年度国際シナプス研究会
- Place of Presentation
  岡崎コンファレンスセンター（愛知県岡崎市）
- Invited
- Data Source
  KAKENHI-PROJECT-23650188
[Presentation] Structure and function of the presynaptic active zone2012
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  24年度国際シナプス研究会
- Place of Presentation
  岡崎コンファレンスセンター（愛知県岡崎市）
- Invited
- Data Source
  KAKENHI-PROJECT-22300120
[Presentation] Structure and function of the presynaptic active zone2012
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  24年度国際シナプス研究会 Nov. 8th-9th
- Place of Presentation
  岡崎
- Data Source
  KAKENHI-PROJECT-22300120
[Presentation] Role of CAST in the structure and function of ribbon synapses2011
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  Ribbon Synapses Symposium
- Place of Presentation
  マックスプランク研究所(ゲッティンゲン)(招待講演)
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-22300120
[Presentation] Role of CAST in the structure and function of ribbon synapses2011
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  Ribbon Synapses Symposium
- Place of Presentation
  Goettingen, Germany
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-23650188
[Presentation] Role of CAST in the structure and function of ribbon synapses2011
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  Ribbon Synapses Symposium
- Place of Presentation
  Goettingen, Germany
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-22300120
[Presentation] Role of CAST in the structure and function of ribbon synapses2011
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  Ribbon Synapses Sympojium(招待講演)
- Place of Presentation
  Germany
- Data Source
  KAKENHI-PROJECT-23650188
[Presentation] 神経伝達物質の放出の動作原理とその破綻2010
- Author(s)
  大塚稔久
- Organizer
  国立精神・神経医療研究センター合同シンポジウム
- Place of Presentation
  東京都小平市
- Year and Date
  2010-11-29
- Data Source
  KAKENHI-PROJECT-22300120
[Presentation] 神経伝達物質放出の分子構造基盤と回路制御2010
- Author(s)
  大塚稔久
- Organizer
  第24回山梨神経科学研究会
- Place of Presentation
  山梨
- Year and Date
  2010-11-24
- Data Source
  KAKENHI-PROJECT-22300120
[Presentation] 神経伝達物質放出の分子構造基盤と回路制御2010
- Author(s)
  大塚稔久
- Organizer
  第24回山梨神経科学研究会講演
- Place of Presentation
  山梨大学医学部
- Year and Date
  2010-11-24
- Data Source
  KAKENHI-PROJECT-22300120
[Presentation] 神経伝達物質の放出の動作原理とその破綻2010
- Author(s)
  大塚稔久
- Organizer
  国立精神・神経医療研究センター合同シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-11-29
- Data Source
  KAKENHI-PROJECT-22300120
[Presentation] 神経終末アクティブゾーンにおけるシグナル伝達2008
- Author(s)
  大塚稔久
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20056009
[Presentation] 神経終末アクティブゾーンにおけるシグナル伝達2008
- Author(s)
  大塚稔久
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20022015
[Presentation] 神経終末アクティブゾーンにおけるシグナル伝達2008
- Author(s)
  大塚稔久
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-18680032
[Presentation] 神経終末アクティブゾーンの分子解剖学2008
- Author(s)
  大塚稔久
- Organizer
  特定領域研究公開シンポジウム「生体膜トランスポートソームの分子構築と生理機能」
- Place of Presentation
  東京
- Year and Date
  2008-03-22
- Data Source
  KAKENHI-PROJECT-18680032
[Presentation] SADキナーゼによるアクチブゾーン特異蛋白質BassoonおよびPiccoloのリン酸化2007
- Author(s)
  Susumu Higa, 所崇, 北島勲, 大塚稔久
- Organizer
  Neuro2007
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18680032
[Presentation] Biochemistry of the presynaptic active zone (regular talk).2007
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  Gordon Research Conferences
- Place of Presentation
  NH, USA.
- Data Source
  KAKENHI-PROJECT-18680032
[Presentation] 神経シナプスアティブ・ゾーンの生化学2007
- Author(s)
  大塚稔久
- Organizer
  第30回日本分子生物会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18059011
[Presentation] 神経シナプスアティブ・ゾーンの生化学2007
- Author(s)
  大塚稔久
- Organizer
  第30回日本分子生物会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18680032
[Presentation] Biochemistry of the presynaptic active zone (regular talk).2007
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  Gordon Research Conferences
- Place of Presentation
  NH, USA.
- Data Source
  KAKENHI-PROJECT-18059011
[Presentation] 神経シナプスアティブ・ゾーンの生化学2007
- Author(s)
  大塚稔久
- Organizer
  第30回日本分子生物会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18021013
[Presentation] SADキナーゼのマウス神経筋接合部における局在2007
- Author(s)
  所崇吉田淑子比嘉進大塚稔久
- Organizer
  Neuro2007
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18680032
[Presentation] Biochemistry of the presynaptic active zone (regular talk).2007
- Author(s)
  Toshihisa Ohtsuka
- Organizer
  Gordon Research Conferences
- Place of Presentation
  NH, USA.
- Data Source
  KAKENHI-PROJECT-18021013
[Presentation] マウス神経筋接合部におけるアクティブゾーン蛋白質CAST/ELKSの局在2006
- Author(s)
  所崇比嘉進北島勲大塚稔久
- Organizer
  分子生物学の未来日本分子生物学会2006 フォーラム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18680032
[Presentation] 学会 The active zone protein CAST directly associates with the Ligand of Numb X2006
- Author(s)
  比嘉進井上英二所崇北島勲大塚稔久
- Organizer
  分子生物学の未来日本分子生物学会2006 フォーラム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18680032

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OHTSUKA Toshihisa 大塚 稔久

Research Projects

Research Products

Co-Researchers

神経シナプスにおけるCAST/ELKS-神経膜制御ネットワークの解明と神経変性疾患への応用Principal Investigator

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Elucidation of mechanism of propagation and aggregation of alpha-synuclein and development of disease-modifying therapies

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液―液相分離の分子操作による神経機能解析Principal Investigator

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Development of Optogenetic Tools for Manipulating Dense-Core Vesicle DynamicsPrincipal Investigator

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アクティブゾーン分子複合体の動態制御機構と多様性の理解Principal Investigator

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ネグレクト発症・回復の予兆検出によるプレシナプス数理モデルの構築Principal Investigator

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２相性インスリン極性分泌機構とその破綻による糖尿病発症

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Pathophysiological study of Bassoon proteinopathy

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シナプス伝達制御と中枢ー末梢機能連関から捉える意志動力学Principal Investigator

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Molecular and structural basis and modification mechanisms of the active zones regulating synaptic transmission efficiencyPrincipal Investigator

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プレシナプス分子の動作原理から捉える適応回路メカニズムPrincipal Investigator

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CAST/ELKSの機能制御から捉える網膜シナプスのスクラップアンドビルドPrincipal Investigator

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Molecular and cellular mechanisms of active zone structure and function by the CAST/ELKS protein familyPrincipal Investigator

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OHTSUKA Toshihisa 大塚稔久