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Hashimoto Shuji  橋本 修二

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HASHIMOTO Syuji  橋本 修二

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Researcher Number 50148334
Other IDs
Affiliation (Current) 2025: 藤田医科大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help 2018 – 2019: 藤田医科大学, 医学部, 教授
2014 – 2017: 藤田保健衛生大学, 医学部, 教授
2015: 藤田保健衛生大学, 医学部衛生学講座, 教授
2009: 藤田保健衛生大学, 医学部, 教授
Review Section/Research Field
Principal Investigator
Epidemiology and preventive medicine
Except Principal Investigator
Epidemiology and preventive medicine / Biological Sciences
Keywords
Principal Investigator
疫学 / 統計 / 研究事例 / 集計可能な内容 / 匿名データ / 二次利用 / 保健医療統計
Except Principal Investigator
生活習慣病 / バイオマーカー / DNAメチル化 … More / エピジェネティクス / 縦断研究 / BDNF / LINE-1 / HIF / LPL / TXNIP / ABCA1 / 分子疫学 / がん分子標的薬剤 / ATL発症リスク / ATL発がん機序 / がん化学予防 / 分子疫学コーホート研究 / ATL発症予防 / 国際交流 / 個別化がん予防 / ゲノム・エピゲノム解析支援 / アカデミア創薬 / 次世代分子解析技術 / ゲノムコーホート研究 / 病理形態学 / 遺伝子改変マウス / 国際研究者交流 / 若手支援 / DNAメチル化 / 一般住民 / コホート研究 / 遺伝子 / メチル化 / 社会医学 / コホート / 匿名化 / 交互作用 / 生体指標 / 遺伝子型 / 生活習慣 / がん / コーホート研究 Less
  • Research Projects

    (5 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (132 People)
  •  Development of secondary use of health and medical statisticsPrincipal Investigator

    • Principal Investigator
      Hashimoto Shuji
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Epidemiology and preventive medicine
    • Research Institution
      Fujita Health University
  •  Longitudinal study on the relationship between the DNA methylation status of metabolism-related genes and the development of lifestyle-related diseases

    • Principal Investigator
      SUZUKI Koji
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Epidemiology and preventive medicine
    • Research Institution
      Fujita Health University
  •  Analysis of the methylation status of leukocytes DNA stored in a longitudial cohort study

    • Principal Investigator
      Suzuki Koji
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Epidemiology and preventive medicine
    • Research Institution
      Fujita Health University
  •  Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

    • Principal Investigator
      IMAI Kohzoh, 中村 祐輔
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      The University of Tokyo
  •  Study on supports for molecular cohort studies

    • Principal Investigator
      HAMAJIMA Nobuyuki
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nagoya University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2005 Other

All Journal Article Presentation

  • [Journal Article] Associations of occupation, employment type and company size with actions related to health examinations among Japanese employees2019

    • Author(s)
      Seko R, Kawado M, Saito S, Shibuya T, Miyamoto M, Yamada H, Taniwaki H, Hashimoto S.
    • Journal Title

      Industrial Health

      Volume: 57 Issue: 4 Pages: 537-546

    • DOI

      10.2486/indhealth.2018-0112

    • NAID

      130007687417

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09138
  • [Journal Article] Associations between dietary vitamin intake, ABCA1 gene promoter DNA methylation, and lipid profiles in a Japanese population2019

    • Author(s)
      Fujii Ryosuke、Yamada Hiroya、Munetsuna Eiji、Yamazaki Mirai、Ando Yoshitaka、Mizuno Genki、Tsuboi Yoshiki、Ohashi Koji、Ishikawa Hiroaki、Hagiwara Chiharu、Maeda Keisuke、Hashimoto Shuji、Suzuki Koji
    • Journal Title

      The American Journal of Clinical Nutrition

      Volume: 110 Issue: 5 Pages: 1213-1219

    • DOI

      10.1093/ajcn/nqz181

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09139, KAKENHI-PROJECT-16H06277
  • [Journal Article] 手助けや見守りを要する者がいる世帯における世帯員の健康とストレスの状況―国民生活基礎調査の匿名データの解析―2019

    • Author(s)
      世古留美, 宮本美穂, 齋藤彩那, 山田宏哉, 川戸美由紀, 谷脇弘茂, 橋本修二
    • Journal Title

      厚生の指標

      Volume: 66(11) Pages: 1-5

    • NAID

      40022025802

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09138
  • [Journal Article] Dietary vegetable intake is inversely associated with ATP-binding cassette protein A1 (ABCA1) DNA methylation levels among Japanese women2019

    • Author(s)
      Fujii Ryosuke、Yamada Hiroya、Munetsuna Eiji、Yamazaki Mirai、Mizuno Genki、Tsuboi Yoshiki、Ohashi Koji、Ishikawa Hiroaki、Ando Yoshitaka、Hagiwara Chiharu、Maeda Keisuke、Hashimoto Shuji、Hamajima Nobuyuki、Suzuki Koji
    • Journal Title

      Nutrition

      Volume: 65 Pages: 1-5

    • DOI

      10.1016/j.nut.2019.02.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Journal Article] Relationship between Long Interspersed Nuclear Element-1 DNA Methylation in Leukocytes and Dyslipidemia in the Japanese General Population2018

    • Author(s)
      Tsuboi Yoshiki、Yamada Hiroya、Munetsuna Eiji、Yamazaki Mirai、Mizuno Genki、Murase Yuri、Ohashi Koji、Ishikawa Hiroaki、Kondo Mari、Inoue Takashi、Hashimoto Shuji、Hamajima Nobuyuki、Suzuki Koji
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 25 Issue: 12 Pages: 1231-1239

    • DOI

      10.5551/jat.43570

    • NAID

      130007539358

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2018-12-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09139, KAKENHI-PROJECT-16H06277
  • [Journal Article] GNAS and Kras cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm.2016

    • Author(s)
      Taki, K., Ohmuraya, M., Tanji, E., Komatsu, H., Hashimoto, D., Semba, K., Araki, K., Kawaguchi, Y., Baba, H. and Furukawa, T.
    • Journal Title

      Oncogene

      Volume: in press Issue: 18 Pages: 1-6

    • DOI

      10.1038/onc.2015.294

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0001, KAKENHI-PLANNED-26110003, KAKENHI-PUBLICLY-26111516, KAKENHI-PROJECT-25640052, KAKENHI-PROJECT-25670653
  • [Journal Article] Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation. Carcinogenesis.2015

    • Author(s)
      Hatano Y, Semi K, Hashimoto K, Lee MS, Hirata A, Tomita H, Kuno T, Takamatsu M, Aoki K, Taketo MM, Kim YJ, Hara A, Yamada Y.
    • Journal Title

      Carcinogenesis

      Volume: 36 Issue: 7 Pages: 719-29

    • DOI

      10.1093/carcin/bgv060

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04721, KAKENHI-PROJECT-26830069, KAKENHI-PROJECT-24680091
  • [Journal Article] Generation and analysis of serine protease inhibitor Kazal type 3-cre driver mice2014

    • Author(s)
      Sakata, K., Ohmuraya, M., Araki, K., Suzuki, C., Ida, S., Hashimoto, D., Wang, J., Uchiyama, Y., Baba, H. and Yamamura, K.
    • Journal Title

      Exp. Anim.

      Volume: 63

    • NAID

      130003391605

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: Results from the SMART database.2014

    • Author(s)
      Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
    • Journal Title

      Mod Rheumatol

      Volume: 27 Issue: 2 Pages: 1-6

    • DOI

      10.3109/14397595.2014.950036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25861575, KAKENHI-PROJECT-15K10818, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101
  • [Journal Article] Rat strain differences in levels and effects of chronic inflammation due to intratracheal instillation of quartz on lung tumorigenesis induced by DHPN2014

    • Author(s)
      Nakano Y, Yokohira M, Hashimoto N, Yamakawa K, Kishi S, Ninomiya F, Kanie S, Saoo K, Imaida K
    • Journal Title

      Exp. Toxicol. Pathol

      Volume: 66 Issue: 8 Pages: 391-401

    • DOI

      10.1016/j.etp.2014.06.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.2013

    • Author(s)
      Hotta H., Hamamura K., Yamashita K,. Shibuya H., Tokuda N., Hashimoto N., Furukawa K., Yamamoto N., Hattori H., Toyokuni S., Ueda M., Furukawa K.
    • Journal Title

      Glycoconj J

      Volume: 30 Issue: 6 Pages: 585-597

    • DOI

      10.1007/s10719-012-9458-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Toxicity of Nicotine by Repeated Intratracheal Instillation to F344 Rats2012

    • Author(s)
      Yokohira M, Nakano Y, Hashimoto N, Yamakawa K, Ninomiya F, Kishi S, Saoo K, Imaida K.
    • Journal Title

      Journal of Toxicologic Pathology

      Volume: 25 Issue: 4 Pages: 257-263

    • DOI

      10.1293/tox.25.257

    • NAID

      130002499152

    • ISSN
      0914-9198, 1881-915X
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Bias of vaccination coverage in a household questionnaire survey in Japan2005

    • Author(s)
      Hashimoto S
    • Journal Title

      J Epidemiol 15

      Pages: 15-19

    • Data Source
      KAKENHI-PROJECT-17015018
  • [Presentation] 住民健診受診者における飲酒習慣と白血球中TXNIP遺伝子のDNAメチル化率との関連2020

    • Author(s)
      前田圭介, 山田宏哉, 宗綱栄二, 山崎未来, 安藤嘉崇, 水野元貴, 大橋鉱二, 石川浩章, 藤井亮輔, 坪井良樹, 萩原千晴, 橋本修二, 浜島信之, 鈴木康司
    • Organizer
      第30回日本疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 一般住民を対象とした脂質クオリティとABCA1遺伝子DNAメチル化率との関連2020

    • Author(s)
      藤井亮輔, 山田宏哉, 宗綱栄二, 山崎未来, 安藤嘉崇, 水野元貴, 大橋鉱二, 石川浩章, 前田圭介, 萩原千晴, 橋本修二, 鈴木康司
    • Organizer
      第90回日本衛生学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 一般住民を対象としたABCA1遺伝子のメチル化関連SNPおよびn-3多価不飽和脂肪酸摂取量とHDLコレステロールとの関連2020

    • Author(s)
      藤井亮輔, 山田宏哉, 安藤嘉崇, 山崎未来, 宗綱栄二, 水野元貴, 大橋鉱二, 石川浩章, 前田圭介, 萩原千晴, 橋本修二, 鈴木康司
    • Organizer
      第30回日本疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 住民健診受診者における糖代謝指標値と白血球中TXNIP遺伝子のDNAメチル化率との関連2019

    • Author(s)
      前田圭介、山田宏哉、宗綱栄二、山崎未来、水野元貴、大橋鉱二、石川浩章、安藤嘉崇、藤井亮輔、萩原千晴、橋本修二、浜島信之、鈴木康司
    • Organizer
      第29回日本疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] Dietary vegetables and vitamins intakes are associated with ABCA1 promoter DNA methylation in women2019

    • Author(s)
      Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Koji Ohashi, Hiroaki Ishikawa, Yoshitaka Ando, Chiharu Hagiwara, Keisuke Maeda, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki
    • Organizer
      第29回日本疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 住民健診受診者における喫煙習慣と白血球中TXNIP遺伝子のDNAメチル化率との関連2019

    • Author(s)
      前田圭介, 山田宏哉, 藤井亮輔, 坪井良樹, 萩原 千晴, 橋本修二, 浜島信之, 鈴木康司
    • Organizer
      第78回日本公衆衛生学会総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 一般住民を対象としたBDNF遺伝子DNAメチル化率と血清カロテノイド値との関連2019

    • Author(s)
      萩原千晴, 山田宏哉, 藤井亮輔, 前田圭介, 橋本修二, 浜島信之, 鈴木康司
    • Organizer
      第78回日本公衆衛生学会総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 職域健診の受診とその後の対応の関連要因2019

    • Author(s)
      世古留美,宮本美穂,加藤勝子, 山田宏哉,川戸美由紀,谷脇弘茂,橋本修二
    • Organizer
      藤田学園医学会
    • Data Source
      KAKENHI-PROJECT-17K09138
  • [Presentation] 一般住民を対象とした脂肪酸の推定摂取量とABCA1遺伝子DNAメチル化率との関連2019

    • Author(s)
      藤井亮輔, 山田宏哉, 宗綱栄二, 大橋鉱二, 石川浩章, 橋本修二, 鈴木康司
    • Organizer
      第51回藤田医学会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 要介護者のいる世帯における世帯員の健康とストレスの状況2018

    • Author(s)
      世古留美,宮本美穂,加藤勝子, 山田宏哉,川戸美由紀,谷脇弘茂,橋本修二
    • Organizer
      藤田学園医学会
    • Data Source
      KAKENHI-PROJECT-17K09138
  • [Presentation] 一般住民を対象としたビタミンE摂取量とABCA1遺伝子DNAメチル化率との関連2018

    • Author(s)
      鈴木康司、山田宏哉、藤井亮輔、坪井良樹、前田圭介、萩原 千晴、橋本修二、浜島信之
    • Organizer
      第77回日本公衆衛生学会総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 一般住民を対象としたABCA1遺伝子DNAメチル化率と血清HDLコレステロール値との関連2018

    • Author(s)
      藤井亮輔、山田宏哉、宗綱栄二、山崎未来、坪井良樹、大橋鉱二、石川浩章、安藤嘉崇、前田圭介、萩原千晴、橋本修二、鈴木康司
    • Organizer
      第50回藤田学園医学会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 住民健診受診者における白血球中ABCA1遺伝子のDNAメチル化率と動脈硬化指標との関連2018

    • Author(s)
      坪井良樹, 山田宏哉, 宗綱栄二, 山崎未来, 近藤真里, 太田駿瑠, 服部裕次, 大橋鉱二, 、石川浩章, 市野直浩, 刑部恵介, 杉本恵子, 井上 孝, 橋本修二, 浜島信之, 鈴木康司
    • Organizer
      第28回日本疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 一般住民における野菜・果物類摂取頻度と白血球中TXNIP遺伝子のDNAメチル化率との関連2018

    • Author(s)
      前田圭介、山田宏哉、藤井亮輔、坪井良樹、萩原千晴、橋本修二、浜島信之、鈴木康司
    • Organizer
      第77回日本公衆衛生学会総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 一般住民を対象としたBDNF遺伝子DNAメチル化率と認知機能との関連2018

    • Author(s)
      萩原 千晴、山田宏哉、藤井亮輔、近藤真理、前田圭介、橋本修二、浜島信之、鈴木康司
    • Organizer
      第77回日本公衆衛生学会総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 白血球中lipoprotein lipase遺伝子のDNAメチル化率と脂肪摂取量との関連2017

    • Author(s)
      坪井 良樹, 山田 宏哉, 近藤 真里, 橋本 修二, 浜島 信之, 若井 建志, 鈴木 康司
    • Organizer
      第76回日本公衆衛生学会総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] LINE-1 hypermethylation in Leukocyte Associated with Increasing of Cancer Mortality Rate in a Japanese Population2017

    • Author(s)
      Tsuboi Y, Yamada H, Munetsuna E, Yamazaki M, Ohashi K, Ishikawa H, Kondo M, Inoue T, Hashimoto S, Hamajima N, Suzuki K.
    • Organizer
      The 21st International Epidemiological Association World Congress of Epidemiology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] 住民健診受診者における白血球DNAメチル化レベルと糖代謝指標値との関連2017

    • Author(s)
      鈴木康司, 山田宏哉, 宗綱栄二, 山崎未来, 坪井良樹, 近藤真里, 水野元貴, 村瀬悠里, 近藤奏子, 太田駿瑠, 大橋鉱二, 石川浩章, 井上 孝, 橋本修二, 浜島信之
    • Organizer
      第27日本疫学会学術総会
    • Place of Presentation
      ベルクラシック甲府(山梨県甲府市)
    • Year and Date
      2017-01-25
    • Data Source
      KAKENHI-PROJECT-26293144
  • [Presentation] 白血球LPL遺伝子のメチル化率と頸動脈内膜中 膜複合体厚との関連2017

    • Author(s)
      鈴木 康司, 山田 宏哉, 坪井 良樹, 近藤 真里, 橋本 修二, 浜島 信之
    • Organizer
      第76回日本公衆衛生学会総会
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] LPL methylation levels in leukocyte and fatty liver in a Japanese population2017

    • Author(s)
      Yamada H, Suzuki K, Yamazaki M, Tsuboi Y, Kondo M, Hamajima N, Hashimoto S.
    • Organizer
      The 21st International Epidemiological Association World Congress of Epidemiology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09139
  • [Presentation] LINE-1 DNA methylation levels in leukocyte and hyperglycemia in a Japanese population.2016

    • Author(s)
      Suzuki K., Yamada H., Munetsuna E., Yamazaki M., Tsuboi Y., Kondo K., Ohashi K., Ishikawa H., Mizuno G., Murase Y., Kondo K., Ichino N., Sugimoto K., Osakabe K., Inoue T., Hashimoto S., Hamajima N.
    • Organizer
      14th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress
    • Place of Presentation
      Taipei (China)
    • Year and Date
      2016-11-26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293144
  • [Presentation] SPINK1ノックインマウスではオートファジー機能不全により慢性膵炎が惹起される

    • Author(s)
      坂田和也, 大村谷昌樹, 荒木喜美, 高城克暢, 橋本大輔, 近本亮, 山村研一, 馬場秀夫
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Presentation] CHOP欠損による慢性炎症からの膵線維化進展

    • Author(s)
      高城克暢, 大村谷昌樹, 橋本大輔, 東孝暁, 坂本慶太, 坂田和也, 新田英利, 林洋光, 近本亮, 別府透, 荒木喜美, 山村研一, 馬場秀夫
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-221S0001
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  • 131.  TAKANO Ken-ichi
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  • 132.  浜嶋 信之
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