KUBO Michiaki 久保充明

Researcher Number	30442958
Other IDs
Affiliation (based on the past Project Information) *help	2015: 国立研究開発法人理化学研究所, その他部局等, その他 2015: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 副センター長 2015: 理化学研究所, ゲノム医科学研究センター, センター長代行 2014: 独立行政法人理化学研究所, 横浜研究所ゲノム医科学研究センター, 副センター長 2014: 理化学研究所, 総合生命医科学研究センター, 副センター長 … More 2013 – 2014: 独立行政法人理化学研究所, その他部局等, その他 2013 – 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 副センター長 2012: 独立行政法人理化学研究所, その他部局等, 研究員 2012: 独立行政法人理化学研究所, ゲノム医科学研究センター, センター長代行 2012: 独立行政法人理化学研究所, ゲノム医科学研究センター, 副センター長 2011: 独立法人理化学研究所, チームリーダー 2011: 独立法人理化学研究所, 理化学研究所, チームリーダー 2011: 独立行政法人理化学研究所, センター長代行 2010 – 2011: 独立行政法人理化学研究所, 横浜研究所・ゲノム医科学研究センター, 副センター長 2010: 独立行政法人理化学研究所, 横浜研究所ゲノム医科学研究センター, 副センター長 2010: 独立行政法人理化学研究所, 理化学研究所, チームリーダー 2009: 独立法人理化学研究所, 理化学研究所, チームリーダー 2009: 独立行政法人理化学研究所, 多型解析技術開発チーム, グループディレクター 2008: 独立行政法人理化学研究所, 遺伝子多型タイピング研究所・支援チーム, グループディレクター 2008: 独立行政法人理化学研究所, 遺伝子多型研究センター・遺伝子多型タイピング研究・支援チーム, グループディレクター Less
Review Section/Research Field	Except Principal Investigator Public health/Health science / Ophthalmology / Urology / Biological Sciences / Metabolomics / Human pathology / Biological Sciences
Keywords	Except Principal Investigator 遺伝子多型 / 糖尿病 / 肥満 / 生活習慣病 / 疫学 / ゲノム / 一塩基多型 / コホート研究 / 慢性腎臓病 / 心血管病 … More / 加齢黄斑変性 / 前向き研究 / 生活習慣 / CDC123,CAMK1D / KCNQ1 / SNPｓ / BMI / 長期追跡 / 追跡研究 / インスリン分泌 / 環境要因 / 危険因子 / ゲノム解析 / 治療反応性 / 高血圧 / 栄養調査 / うつ症状 / 断面調査 / うつ / 食事調査 / 身体活動量 / 遺伝環境相互作用 / ゲノム疫学 / 遺伝子－環境相互作用 / 睡眠 / 低血糖 / 8q24 / NKX3.1 / IRX4 / バイオマーカー / 前立腺がん / SNP / GWAS / 前立腺癌 / がん分子標的薬剤 / ATL発症リスク / ATL発がん機序 / がん化学予防 / 分子疫学コーホート研究 / ATL発症予防 / 国際交流 / 個別化がん予防 / ゲノム・エピゲノム解析支援 / アカデミア創薬 / 次世代分子解析技術 / ゲノムコーホート研究 / 病理形態学 / 遺伝子改変マウス / 国際研究者交流 / 若手支援 / 心血管病死亡率 / 総死亡率 / 高感度C反応性蛋白 / 1,25(OH)2ビタミンD / EPA/AA濃度比 / 脂肪酸分画 / メタボリックシンドローム / 虚血性心疾患 / 追跡調査 / エイコサセン酸 / 脂肪酸分面 / 疫学研究 / メタボリック・シンドローム / 代謝性疾患 / 関連遺伝子 / 一塩基遺伝子多型 / 死亡 / 悪性腫瘍 / ビタミンD / アラキドン酸 / エイコサペンタエン酸 / 脂質メディエーター / ゲノムワイドアプローチ / 遺伝子解析 / 地域住民 / 日本人 / 糖質代謝異常 / エネルギー / heme oxvgenase-1(HO-1) / PKCη / 可溶型Tie-2連関 / Ang-1 / 久山町コホート研究 / PKCアイソフォーム / 遺伝子治療 / podoplanin / PKC アイソフォーム / 色素上皮細胞由来因子(PEDF) / 可溶型Tie-2 / 川崎病 / 血管新生 / 動脈硬化 / 匿名化 / 交互作用 / 生体指標 / 遺伝子型 / がん / コーホート研究 Less

Genomic epideological study of age-related macular degenration to develop individualized medicine
- Principal Investigator
  
  TATSURO Ishibashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Kyushu University
Longitudinal study of insulin secretion taking into account genetic and environmental factors in a general population: the Hisayama Study
- Principal Investigator
  
  DOI Yasufumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Public health/Health science
- Research Institution
  Kyushu University
The Fukuoka Diabetes Registry
- Principal Investigator
  
  Iwase Masanori
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Public health/Health science
- Research Institution
  Kyushu University
Genes/SNPs of lipid mediators and diseases
- Principal Investigator
  
  YUTAKA Kiyohara
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- Principal Investigator
  
  IMAI Kohzoh, 中村祐輔
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Comprehensive genome analysis for prostate cancer biomarkers
- Principal Investigator
  
  NAKAGAWA Hidewaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  The Institute of Physical and Chemical Research
Genome-wide association study identifies two susceptibility loci for agerelated macular degeneration in the Japanese population
- Principal Investigator
  
  ISHIBASHI Tatsuro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Kyushu University
SNPs drived form diabetes GWAS and incidence of diabetes in a general population : the Hisayama Study
- Principal Investigator
  
  DOI Yasufumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyushu University
Moleculo-pathological Study on Vascular Remodeling in Japanese
- Principal Investigator
  
  SUEISHI Katsuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  Kyushu University
Study on supports for molecular cohort studies
- Principal Investigator
  
  HAMAJIMA Nobuyuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Patent Other

[Journal Article] Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer2016
- Author(s)
  Okada R, Naito M, Hattori Y, Seiki T, Wakai K, Nanri H, Watanabe M, Suzuki S, Kairupan TS, Takashima N, Mikami H, Ohnaka K, Watanabe Y, Katsuura-Kamano S, Kubo M, Hamajima N, Tanaka H; Japan Multi-institutional Collaborative Cohort Study Group
- Journal Title
  
  Gastric Cancer
  
  Volume: ahead of print Issue: 2 Pages: 246-253
- DOI
  10.1007/s10120-016-0608-2
- NAID
  40021129395
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-16H06277
[Journal Article] Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure2016
- Author(s)
  Baba M, Toyama H, Sun L, Takubo K, Suh HC, Hasumi H, Nakamura-Ishizu A, Hasumi Y, Klarmann KD, Nakagata N, Schmidt LS, Linehan WM, Suda T, Keller JR
- Journal Title
  
  Stem Cells
  
  Volume: 34 Issue: 4 Pages: 1068-1082
- DOI
  10.1002/stem.2293
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14370, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04975, KAKENHI-PROJECT-26221309
[Journal Article] "Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population"2016
- Author(s)
  Nishida Y, Hara M, Sakamoto T, Shinchi K, Kawai S, Naito M, Hamajima N, Kadota A, Suzuki S, Ibusuki R, Hirata A, Yamaguchi M, Kuriyama N, Oze I, Mikami H, Kubo M, Tanaka H.
- Journal Title
  
  Prev. Med. Rep.
  
  Volume: 3 Pages: 288-295
- DOI
  10.1016/j.pmedr.2016.03.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26293141, KAKENHI-PROJECT-26460757
[Journal Article] Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men2015
- Author(s)
  Koyama, T. Matsui, D. Kuriyama, N. Ozaki, E. Tanaka, K. Oze, I. Hamajima, N. Wakai, K. Okada, R. Arisawa, K. Mikami, H. Shimatani, K. Hirata, A. Takashima, N. Suzuki, S. Nagata, C. Kubo, M. Tanaka, H.
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 15888-15888
- DOI
  10.1038/srep15888
- NAID
  120006875676
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26293141
[Journal Article] Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols.2015
- Author(s)
  Shiwa Y, Hachiya T, Furukawa R, Ohmomo H, Ono K, Kudo H, Hata J, Hozawa A, Iwasaki M, Matsuda K, Minegishi N, Satoh M, Tanno K, Yamaji T, Wakai K, Hitomi J, Kiyohara Y, Kubo M, Tanaka H, Tsugane S, Yamamoto M, Sobue K, Shimizu A.
- Journal Title
  
  PLoS ONE
  
  Volume: 6 Issue: 1 Pages: 8018-8018
- DOI
  10.1371/journal.pone.0147519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09464, KAKENHI-PROJECT-26460776, KAKENHI-PROJECT-26461482, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-25461138
[Journal Article] Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis.2015
- Author(s)
  Matsuura E, Kubota R, Tanaka Y, Takashima H, Izumo S
- Journal Title
  
  J Neuropath Exp Neurol.
  
  Volume: 74 Issue: 1 Pages: 2-14
- DOI
  10.1097/nen.0000000000000141
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591271, KAKENHI-PROJECT-25305017, KAKENHI-PROJECT-221S0001
[Journal Article] Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study.2015
- Author(s)
  Yamaguchi M, Uemura H, Arisawa K, Katsuura-Kamano S, Hamajima N, Hishida A, Suma S, Oze I, Nakamura K, Takashima N, Suzuki S, Ibusuki R, Mikami H, Ohnaka K, Kuriyama N, Kubo M, Tanaka H.
- Journal Title
  
  Diabetes Res. Clin. Pract.
  
  Volume: 110 Issue: 3 Pages: 301-308
- DOI
  10.1016/j.diabres.2015.10.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460757, KAKENHI-PROJECT-221S0001
[Journal Article] A variant of the CLOCK gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population. Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group.2015
- Author(s)
  Uemura H, Katsuura-Kamano S, Yamaguchi M, Arisawa K, Hamajima N, Hishida A, Kawai S, Oze I, Shinchi K, Takashima N, Suzuki S, Nakahata N, Mikami H, Ohnaka K, Kuriyama N, Kubo M, Tanaka H.
- Journal Title
  
  J Diabetes
  
  Volume: online Issue: 5 Pages: 667-676
- DOI
  10.1111/1753-0407.12344
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460757, KAKENHI-PROJECT-221S0001
[Journal Article] Associations between polymorphisms of interleukin-6 and related cytokine genes and serum liver damage markers: a cross-sectional study in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.2015
- Author(s)
  Sugimoto Y, Wakai K, Nakagawa H, Suma S, Sasakabe T, Sakamoto T, Takashima N, Suzuki S, Ogawa S, Ohnaka K, Kuriyama N, Arisawa K, Mikami H, Kubo M, Hosono S, Hamajima N, Tanaka H; J-MICC Study Group.
- Journal Title
  
  Gene.
  
  Volume: 557 Issue: 2 Pages: 158-162
- DOI
  10.1016/j.gene.2014.12.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460757, KAKENHI-PROJECT-221S0001
[Journal Article] A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese2015
- Author(s)
  Hirokawa, M., Morita H., Tajima T., Takahashi A., Ashikawa K., Miya F., Shigemizu D., Ozaki K., Sakata Y., Nakatani D., Suna S., Imai Y., Tanaka T., Tsunoda T., Matsuda K., Kadowaki T., Nakamura Y., Nagai R., Komuro I. and Kubo M.
- Journal Title
  
  Eur J Hum Genet
  
  Volume: 23 Issue: 3 Pages: 374-380
- DOI
  10.1038/ejhg.2014.110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26000012
[Journal Article] HLA-A SNPs and amino acid variants are associated with nasopharyngeal carcinoma in Malaysian Chinese2015
- Author(s)
  Chin, Y.M., Mushiroda T., Takahashi A., Kubo M., Krishnan G., Yap L.F., Teo S.H., Lim P.V., Yap Y.Y., Pua K.C., Kamatani N., Nakamura Y., Sam C.K., Khoo A.S., Malaysian N.P.C.S.G. and Ng C.C.
- Journal Title
  
  Int J Cancer
  
  Volume: 136 Issue: 3 Pages: 678-687
- DOI
  10.1002/ijc.29035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Association of genetically determined aldehyde dehydrogenase 2 activity with diabetic complications in relation to alcohol consumption in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry.2015
- Author(s)
  Yasuhiro Idewaki, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Shinako Kaizu, Tamaki Jodai, Yohei Kikuchi, Atsushi Hirano, Udai Nakamura, Michiaki Kubo, Takanari Kitazono
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 11 Pages: e0143288-e0143288
- DOI
  10.1371/journal.pone.0143288
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23249037
[Journal Article] Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population.2015
- Author(s)
  Matsuda K, Takahashi A, Middlebrooks CD, Obara W, Nasu Y, Inoue K, Tamura K, Yamasaki I, Naya Y, Tanikawa C, Cui R, Figueroa JD, Silverman DT, Rothman N, Namiki M, Tomita Y, Nishiyama H, Kohri K, Deguchi T, Nakagawa M, Yokoyama M, Miki T, Kumon H, Fujioka T, Prokunina-Olsson L, Kubo M, Nakamura Y, Shuin T.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 24 Issue: 4 Pages: 1177-1184
- DOI
  10.1093/hmg/ddu512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293168, KAKENHI-PROJECT-25710009, KAKENHI-PROJECT-221S0001
[Journal Article] Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women. Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.2015
- Author(s)
  Hosono S, Ito H, Oze I, Higaki Y, Morita E, Takashima N, Suzuki S, Shimatani K, Mikami H, Ohnaka K, Ozaki E. Katsuura-Kamano S, Kubo M, Nagata C, Naito M, Hamajima N, Tanaka H.
- Journal Title
  
  Maturitas
  
  Volume: 62 Issue: 4 Pages: 394-401
- DOI
  10.1016/j.maturitas.2015.08.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460757, KAKENHI-PROJECT-221S0001
[Journal Article] Association between endometriosis and the interleukin 1A (IL1A) locus2015
- Author(s)
  Sapkota, Y., Low S.K., Attia J., Gordon S.D., Henders A.K., Holliday E.G., MacGregor S., Martin N.G., McEvoy M., Morris A.P., Takahashi A., Scott R.J., Kubo M., Zondervan K.T., Montgomery G.W. and Nyholt D.R.
- Journal Title
  
  Hum Reprod
  
  Volume: 30 Issue: 1 Pages: 239-248
- DOI
  10.1093/humrep/deu267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer.2015
- Author(s)
  Shinmura K, Kato H, Kawanishi Y, Nagura K, Kamo T, Okubo Y, Inoue Y, Kurabe N, Du C, Iwaizumi M, Kurachi K, Nakamura T, Sugimura H.
- Journal Title
  
  Oncol Rep.
  
  Volume: 34 Issue: 2 Pages: 727-738
- DOI
  10.3892/or.2015.4014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose in the Japanese general population.2014
- Author(s)
  Hara M, Nakamura K, Nanri H, KIta Y, Suzuki S, Ohnaka K, Mikami H, Kubo M, Tanaka H et al.
- Journal Title
  
  Journal of epidemiology / Japan Epidemiological Association
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] A meta-analysis of genome-wide association studies for adiponectin level in East Asians identifies a novel locus near WDR11-FGFR2.2014
- Author(s)
  M.Yokota(他49 名、47番目）et al
- Journal Title
  
  Hum Mol Genet
  
  Volume: 23(4) Issue: 6 Pages: 1108-1119
- DOI
  10.1093/hmg/ddu583
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390169, KAKENHI-PROJECT-25293144, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-221S0002
[Journal Article] Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study.2014
- Author(s)
  Hishida A, Wakai K, Naito M, Suma S, Sasakabe T, Hamajima N, Hosono S, Horita M, Turin TC, Suzuki S, Kairupan TS, Mikami H, Ohnaka K, Watanabe I, Uemura H, Kubo M, Tanaka H; J-MICC Study Group.
- Journal Title
  
  Lipids Health Dis.
  
  Volume: 13 Issue: 1 Pages: 162-162
- DOI
  10.1186/1476-511x-13-162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460757, KAKENHI-PROJECT-221S0001
[Journal Article] Genome-wide association study : a useful tool to identify common genetic variants associated with drugtoxicity and efficacy in cancer pharmacogenomics2014
- Author(s)
  Low, S.K., Takahashi A., Mushiroda T. and Kubo M.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 20 Issue: 10 Pages: 2541-2552
- DOI
  10.1158/1078-0432.ccr-13-2755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Combination of Bevacizumab and Acyclic Retinoid Inhibits the Growth of Hepatocellular Carcinoma Xenografts2014
- Author(s)
  Kubota M, Shimizu M, Baba A, Ohno T, Kochi T, Shirakami Y, Moriwaki H.
- Journal Title
  
  Journal of Nutritional Science and Vitaminology
  
  Volume: 60 Issue: 5 Pages: 357-362
- DOI
  10.3177/jnsv.60.357
- NAID
  130004773635
- ISSN
  0301-4800, 1881-7742
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-221S0001
[Journal Article] GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: data from the J-MICC Study.2014
- Author(s)
  Hishida A, Takashima N, Turin TC, Kawai S, Wakai K, Hamajima N, Hosono S, Nishida Y, Suzuki S, Nakahata N, Mikami H, Ohnaka K, Matsui D, Katsuura-Kamano S, Kubo M, Tanaka H, Kita Y.
- Journal Title
  
  J Nephrol
  
  Volume: 27(2) Issue: 2 Pages: 143-149
- DOI
  10.1007/s40620-013-0025-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390165, KAKENHI-PROJECT-26460757, KAKENHI-PROJECT-221S0001
[Journal Article] Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.2014
- Author(s)
  Chen P, Takeuchi F, Lee JY,.., Kita Y, et al
- Journal Title
  
  Diabetes
  
  Volume: 63(7) Issue: 7 Pages: 2551-2562
- DOI
  10.2337/db13-1815
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390165, KAKENHI-PROJECT-24390166, KAKENHI-PROJECT-221S0001
[Journal Article] A rare polymorphic variant of NBS1 reduces DNA repair activity and elevates chromosomal instability2014
- Author(s)
  Yamamoto, Y., Miyamoto M., Tatsuda D., Kubo M., Nakagama H., Nakamura Y., Satoh H., Matsuda K., Watanabe T. and Ohta T.
- Journal Title
  
  Cancer Res
  
  Volume: 74 Issue: 14 Pages: 3707-3715
- DOI
  10.1158/0008-5472.can-13-3037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Citalopram and escitalopram plasma drug and metabolite concentrations : genome-wide associations2014
- Author(s)
  Ji, Y., Schaid D.J., Desta Z., Kubo M., Batzler A.J., Snyder K., Mushiroda T., Kamatani N., Ogburn E., Hall-Flavin D., Flockhart D., Nakamura Y., Mrazek D.A. and Weinshilboum R.M.
- Journal Title
  
  Br J Clin Pharmacol
  
  Volume: 78 Issue: 2 Pages: 373-383
- DOI
  10.1111/bcp.12348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids2014
- Author(s)
  Park, H.W., Dahlin A., Tse S., Duan Q.L., Schuemann B., Martinez F.D., Peters S.P., Szefler S.J., Lima J.J., Kubo M., Tamari M. and Tantisira K.G.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 133 Issue: 3 Pages: 664-669.e5
- DOI
  10.1016/j.jaci.2013.12.1042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Alexithymia is associated with greater risk of chronic pain and negative affect and with lower life satisfaction in a general population: the Hisayama Study.2014
- Author(s)
  Shibata M, Ninomiya T, Jensen MP, Anno K, Yonemoto K, Makino S, Iwaki R, Yamashiro K, Yoshida T, Imada Y, Kubo C, Kiyohara Y, Sudo N, Hosoi M.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 3 Pages: e90984-e90984
- DOI
  10.1371/journal.pone.0090984
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22116010, KAKENHI-PROJECT-25253048
[Journal Article] Trans-ethnic meta-analysis of white blood cell phenotypes2014
- Author(s)
  Keller, M.F., Reiner A.P., Okada Y., van Rooij F.J., Johnson A.D., Chen M.H., Smith A.V., Morris A.P., Tanaka T., Ferrucci L., Zonderman A.B., Lettre G., Kamatani Y., Matsuda K., Kamatani N., Nakamura Y., Kubo M., Takahashi A., Wilson J.G., BioBank Japan Project Working Groups, et al.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 23 Issue: 25 Pages: 6944-6960
- DOI
  10.1093/hmg/ddu401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Genetics of rheumatoid arthritis contributes to biology and drug discovery.2014
- Author(s)
  Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, （省略）, GARNET consortium, （以下省略）.
- Journal Title
  
  Nature
  
  Volume: 506 Issue: 7488 Pages: 376-381
- DOI
  10.1038/nature12873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22133008, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390360, KAKENHI-PROJECT-24592285, KAKENHI-PROJECT-25293225, KAKENHI-PROJECT-26460649, KAKENHI-PROJECT-221S0001
[Journal Article] Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese2014
- Author(s)
  Lubitz, S.A., Lunetta K.L., Lin H., Arking D.E., Trompet S., Li G., Krijthe B.P., Chasman D.I., Barnard J., Kleber M.E., Dorr M., Ozaki K., Smith A.V., Muller-Nurasyid M., Walter S., Agarwal S.K., Kubo M., Tanaka T., Heckbert S.R., Jukema J.W., et al.
- Journal Title
  
  J Am Coll Cardiol
  
  Volume: 63 Issue: 12 Pages: 1200-1210
- DOI
  10.1016/j.jacc.2013.12.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.2014
- Author(s)
  Nakajima M, Takahashi A, Tsuji T, Furukawa K-I et al.
- Journal Title
  
  Nature Genetics
  
  Volume: 46 Issue: 9 Pages: 1012-1016
- DOI
  10.1038/ng.3045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590310, KAKENHI-PROJECT-24592194, KAKENHI-PROJECT-26293332, KAKENHI-PROJECT-26670654, KAKENHI-PROJECT-221S0001
[Journal Article] The construction of risk prediction models using GWAS data and its application to a type 2 diabetes prospective cohort2014
- Author(s)
  Shigemizu D, Abe T, Morizono T, Johnson TA, Boroevich KA, Hirakawa Y, Ninomiya T, Kiyohara Y, Kubo M, Nakamura Y, Maeda S, Tsunoda T
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 3 Pages: e92549-e92549
- DOI
  10.1371/journal.pone.0092549
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22134008, KAKENHI-PROJECT-221S0001
[Journal Article] Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin2014
- Author(s)
  Goswami, S., Yee S.W., Stocker S., Mosley J.D., Kubo M., Castro R., Mefford J.A., Wen C., Liang X., Witte J., Brett C., Maeda S., Simpson M.D., Hedderson M.M., Davis R.L., Roden D.M., Giacomini K.M. and Savic R.M.
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 96 Issue: 3 Pages: 370-379
- DOI
  10.1038/clpt.2014.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians2014
- Author(s)
  Zhang, B., Jia W.H., Matsuo K., Shin A., Xiang Y.B., Matsuda K., Jee S.H., Kim D.H., Cheah P.Y., Ren Z., Cai Q., Long J., Shi J., Wen W., Yang G., Ji B.T., Pan Z.Z., Matsuda F., Kubo M., Hosono S., et al.
- Journal Title
  
  Int J Cancer
  
  Volume: 135 Issue: 4 Pages: 948-955
- DOI
  10.1002/ijc.28733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Establishment of CYP2D6 reference samples by multiple validated genotyping platforms2014
- Author(s)
  Fang, H., Liu X., Ramirez J., Choudhury N., Kubo M., Im H.K., Konkashbaev A., Cox N.J., Ratain M.J., Nakamura Y. and O'Donnell P.H.
- Journal Title
  
  Pharmacogenomics J
  
  Volume: 14 Issue: 6 Pages: 564-572
- DOI
  10.1038/tpj.2014.27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Comparative proteomics analysis of gastric cancer stem cells2014
- Author(s)
  Morisaki T, Yashiro M, Kakehashi A, Inagaki A, Kinoshita H, Fukuoka T, Kasashima H, Masuda G, Sakurai K, Kubo N, Muguruma K, Ohira M, Wanibuchi H, Hirakawa K.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 11 Pages: e110736-e110736
- DOI
  10.1371/journal.pone.0110736
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390329, KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-221S0001
[Journal Article] Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population2014
- Author(s)
  Hara, M., Nakamura K., Nanri H., Nishida Y., Hishida A., Kawai S., Hamajima N., Kita Y., Suzuki S., Mantjoro E.M., Ohnaka K., Uemura H., Matsui D., Oze I., Mikami H., Kubo M., Tanaka H. and Japan Multi-Institutional Collaborative Cohort Study Group
- Journal Title
  
  J Epidemiol
  
  Volume: 24
- NAID
  130004449419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] A genome-wide association study to identify genomic modulators of rate control therapy in patients with atrial fibrillation2014
- Author(s)
  Kolek, M.J., Edwards T.L., Muhammad R., Balouch A., Shoemaker M.B., Blair M.A., Kor K.C., Takahashi A., Kubo M., Roden D.M., Tanaka T. and Darbar D.
- Journal Title
  
  Am J Cardiol
  
  Volume: 114 Issue: 4 Pages: 593-600
- DOI
  10.1016/j.amjcard.2014.05.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] interferon lambda 4/interleukin-28B haplotype structure and its impact on susceptibility to hepatitis C virus and treatment response in the Japanese population2014
- Author(s)
  Ochi H, Miki D, Hayes CN, Abe H, Hayashida Y, Kubo M, Chayama K
- Journal Title
  
  Journal of General Virology
  
  Volume: 95巻 Issue: 6 Pages: 1297-306
- DOI
  10.1099/vir.0.060103-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-221S0001
[Journal Article] Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).2014
- Author(s)
  Chhibber A, Mefford J, Zembutsu H et al
- Journal Title
  
  Pharmacogenomics J.
  
  Volume: 14 Issue: 4 Pages: 336-342
- DOI
  10.1038/tpj.2014.2
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300338, KAKENHI-PROJECT-221S0001
[Journal Article] A rare Japanese case with a NUT midline carcinoma in the nasal cavity : A case report with immunohistochemical and genetic analyses2014
- Author(s)
  Suzuki S, Sugimura H et al.
- Journal Title
  
  Pathol Res Pract
  
  Volume: 210(6) Issue: 6 Pages: 383-8
- DOI
  10.1016/j.prp.2014.01.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659161, KAKENHI-PROJECT-26460660, KAKENHI-PROJECT-221S0001
[Journal Article] Aromatase inhibitor-associated bone fractures : a case-cohort GWAS and functional genomics2014
- Author(s)
  Liu, M., Goss P.E., Ingle J.N., Kubo M., Furukawa Y., Batzler A., Jenkins G.D., Carlson E.E., Nakamura Y., Schaid D.J., Chapman J.A., Shepherd L.E., Ellis M.J., Khosla S., Wang L. and Weinshilboum R.M.
- Journal Title
  
  Mol Endocrinol
  
  Volume: 28 Issue: 10 Pages: 1740-1751
- DOI
  10.1210/me.2014-1147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Identification of genomic locus responsible for experimentally induced testicular teratoma 1 (ett1) on mouse Chr 182014
- Author(s)
  Miyazaki T, Ikeda Y, Kubo I, Suganuma S, Fujita N, Itakura M, Hayashi T, Takabayashi S, Katoh H, Ohira Y, Sato M, Noguchi M, Tokumoto T
- Journal Title
  
  Mammalian Genome
  
  Volume: 25 Issue: 7-8 Pages: 317-326
- DOI
  10.1007/s00335-014-9529-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24580411, KAKENHI-PROJECT-221S0001
[Journal Article] Development of a SNP set for human identification : A set with high powers of discrimination which yields high genetic information from naturally degraded DNA samples in the Thai population2014
- Author(s)
  Boonyarit, H., Mahasirimongkol S., Chavalvechakul N., Aoki M., Amitani H., Hosono N., Kamatani N., Kubo M. and Lertrit P.
- Journal Title
  
  Forensic Sci Int Genet
  
  Volume: 11 Pages: 166-173
- DOI
  10.1016/j.fsigen.2014.03.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer2014
- Author(s)
  Al Olama, A.A., Kote-Jarai Z., Bemdt S.I., Conti D.V., Schumacher F., Han Y., Benlloch S., Hazelett D.J., Wang Z., Saunders E., Leongamornlert D., Lindstrom S., Jugurnauth-Little S., Dadaev T., Tymrakiewicz M., Stram D.O., Rand K., Wan P., Stram A., Kubo M., et al.
- Journal Title
  
  Nat Genet
  
  Volume: 46 Issue: 10 Pages: 1103-1109
- DOI
  10.1038/ng.3094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Integrating genetic, transcriptional, and functional analyses to identify five novel genes for atrial fibrillation2014
- Author(s)
  Sinner MF, Tucker N, Lunetta K, Ozaki K, Smith G, Trompet S, Bis J, Lin H, Chung M, Nielsen JB, Lubitz S, Krijthe B, Magnani J, Ye J, Gollob M, Tsunoda T, Müller-Nurasyid M, Lichtner P, Peters A, Dolmatova E, Kubo M, Smith J, Psaty B, Smith N, Jukema JW, Chasman D, Ebana Y, Furukawa T, et al. (他27名)
- Journal Title
  
  Circulation
  
  Volume: 130 Issue: 15 Pages: 1225-1235
- DOI
  10.1161/circulationaha.114.009892
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293052, KAKENHI-PROJECT-221S0001
[Journal Article] Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1,5q14.3 and 15q26.12014
- Author(s)
  Cai, Q., Zhang B., Sung H., Low S.K., Kweon S.S., Shen C.Y., Matsuo K., Teo S.H., Kim M.K., Iwasaki M., Hartman M., Takahashi A., Ashikawa K., Matsuda K., Ito H., Kasuga Y., Iwata H., Tsugane S., Nakamura Y., Kubo M., et al.
- Journal Title
  
  Nat Genet
  
  Volume: 46 Issue: 8 Pages: 886-890
- DOI
  10.1038/ng.3041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.2014
- Author(s)
  Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Ohkubo T, Takashima N, Miki T, et al.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 23 Issue: 20 Pages: 5492-5504
- DOI
  10.1093/hmg/ddu248
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390084, KAKENHI-PROJECT-25293141, KAKENHI-PROJECT-221S0001
[Journal Article] A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study.2014
- Author(s)
  Katsuura-Kamano S, Uemura H, Arisawa K, Yamaguchi M, Hamajima N, Wakai K, Okada R, Suzuki S, Taguchi N, Kita Y, Ohnaka K, Kairupan TS, Matsui D, Oze I, Mikami H, Kubo M, Tanaka H.
- Journal Title
  
  Endocrine.
  
  Volume: 47 Issue: 1 Pages: 81-89
- DOI
  10.1007/s12020-014-0306-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460757, KAKENHI-PROJECT-221S0001
[Journal Article] Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study2013
- Author(s)
 Mineyoshi Hiyoshi, Hirokazu Uemura, Kokichi Arisawa, Mariko Nakamoto, Asahi Hishida, Rieko Okada, Keitaro Matsuo, Yoshikuni Kita, Hideshi Niimura, Nagato Kuriyama, Hinako Nanri, Keizo Ohnaka, Sadao Suzuki, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima,
- Journal Title
 
 Journal of Clinical Biochemistry and Nutrition
 
 Volume: 53 Issue: 1 Pages: 15-20
- DOI
 10.3164/jcbn.13-17
- NAID
 130004879346
- ISSN
 0912-0009, 1880-5086
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-25870517, KAKENHI-PROJECT-221S0001
[Journal Article] Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese — the J-MICC Study [Rapid Communication]2013
- Author(s)
 Hishida A, Wakai K, Okada R, Suzuki S, Mikami H, Kubo M, Tanaka H, Naito M et al.
- Journal Title
 
 Endocr J
 
 Volume: 60 Issue: 2 Pages: 237-243
- DOI
 10.1507/endocrj.EJ12-0307
- NAID
 10031156747
- ISSN
 0918-8959, 1348-4540
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-221S0001
[Journal Article] Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study.2013
- Author(s)
  Hishida A, Wakai K, Naito M, Suzuki S, Mikami H, Ohnaka K, Watanabe Y, Arisawa K, Kubo M, Tanaka H et al.
- Journal Title
  
  PPAR research 2013
  
  Volume: - Pages: 980471-980471
- DOI
  10.1155/2013/980471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study.2013
- Author(s)
  Hishida A, Okada R, Guang Y, Naito M, Wakai K, Suzuki S, Mikami H, Kubo M, Tanaka H et al.
- Journal Title
  
  International urology and nephrology
  
  Volume: 45 Issue: 6 Pages: 1613-1620
- DOI
  10.1007/s11255-013-0432-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Gene-gene combination effect and interactions among ABCA1, APOA1, SR-B1, and CETP polymorphisms for serum high-density lipoprotein-cholesterol in the Japanese population.2013
- Author(s)
  Nakamura A, Niimura H, Kuwabara K, Takezaki T, Wakai K, Suzuki S, Ohnaka K, Mikami H, Kubo M, Tanaka H et al.
- Journal Title
  
  PloS one
  
  Volume: 8 Issue: 12 Pages: e82046-e82046
- DOI
  10.1371/journal.pone.0082046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Impact of allele copy number of polymorphisms in FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis.2013
- Author(s)
  Asano K, Matsumoto T, Umeno J, Hirano A, Esaki M, Hosono N, Matsui T, Kiyohara Y, Nakamura Y, Kubo M, Kitazono T.
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: 19 Issue: 10 Pages: 2061-2068
- DOI
  10.1097/mib.0b013e318298118e
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22116010, KAKENHI-PROJECT-23256005, KAKENHI-PROJECT-23710225, KAKENHI-PROJECT-25253048
[Journal Article] Identification of a Selective Inhibitor of KDM2/7 Histone Lysine Demethylases and its Antiproliferative Activity.2013
- Author(s)
  Suzuki T, Ozasa H, Itoh Y, Zhan P, Sawada H, Mino K, Walport L, Ohkubo R, Kawamura A, Yonezawa M, Tsukada Y, Tumber A, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Schofield CJ, Miyata N
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 56 Issue: 18 Pages: 7222-7231
- DOI
  10.1021/jm400624b
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-24770165, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112008, KAKENHI-PROJECT-221S0001
[Journal Article] Evaluating genetic risk for prostate cancer among Japanese and Latinos2012
- Author(s)
  Cheng I, Chen GK, Nakagawa H, He J, Wan P, Laurie C, Shen J, Sheng X, Pooler LC, Crenshaw AT, Mirel DB, Takahashi A, Kubo K, Nakamura Y, Al Olama AA, Benlloch S, Donovan JL, Guy M, Hamdy FC, Kote-Jarai Z, Neal DE, Wilkens LR, Monroe KR, Stram DO, Muir K, Eeles RA, Easton DF, Kolonel LN, Henderson BE, Le Marchand L, Haiman CA
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev
  
  Volume: 21 Pages: 2048-2058
- Data Source
  KAKENHI-PROJECT-22390306
[Journal Article] Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese2012
- Author(s)
  Akamatsu S, Takahashi A, Takata R, Kubo M, Inoue T, Morizono T, Tsunoda T, Kamatani N, Haiman CA, Wan P, Chen GK, Le Marchand L, Kolonel LN, Henderson BE, Fujioka T, Habuchi T, Nakamura Y, Ogawa O, Nakagawa H
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- Data Source
  KAKENHI-PROJECT-22390306
[Journal Article] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese2012
- Author(s)
  Akamatsu S, Takata R, Haiman CA, Takahashi A, Inoue T, Kubo M, Furihata M, Kamatani N, Inazawa J, Chen GK, Le Marchand L, Kolonel LN, Katoh T, Yamano Y, Yamakado M, Takahashi H, Yamada H, Egawa S, Fujioka T, Henderson BE, Habuchi T, Ogawa O, Nakamura Y, Nakagawa H
- Journal Title
  
  Nat Genet
  
  Volume: 44 Pages: 426-429
- Data Source
  KAKENHI-PROJECT-22390306
[Journal Article] A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population2012
- Author(s)
  Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, Watanabe S, Tsuta K, Kamatani N, Yoshida T, Nakamura Y, Yokota J, Kubo M, Kohno T
- Journal Title
  
  Nature Genetics
  
  Volume: 44 Issue: 8 Pages: 900-903
- DOI
  10.1038/ng.2353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650624, KAKENHI-PROJECT-24390145, KAKENHI-PROJECT-24790340, KAKENHI-PLANNED-22116010, KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-221S0001
[Journal Article] Prostate cancer genomics, biology, and risk assessment through genome-wide association studies2012
- Author(s)
  Nakagawa H, Akamatsu S, Takata R, Takahashi A, Kubo M, and Nakamura Y
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Pages: 607-613
- Data Source
  KAKENHI-PROJECT-22390306
[Journal Article] IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility2012
- Author(s)
  Nguyen HH, Takata R, Akamatsu S, Shigemizu D, Tsunoda T, Furihata M, Takahashi A, Kubo M, Kamatani N, Ogawa O, Fujioka T, Nakamura Y, Nakagawa H
- Journal Title
  
  Hum Mol Genet
  
  Volume: 21 Pages: 2076-2085
- Data Source
  KAKENHI-PROJECT-22390306
[Journal Article] Prospective study on waist circumference and risk of all-cause and cardiovascular mortality: pooled analysis of Japanese community-based studies2012
- Author(s)
  Saito, I. Kokubo, Y. Kiyohara, Y. Doi, Y. Saitoh, S. Ohnishi, H. Miyamoto, Y.
- Journal Title
  
  Circ J
  
  Volume: 76 Pages: 2867-2874
- NAID
  10031126060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590797
[Journal Article] Genome-wide association study identifies two susceptibility loci for exudative age-ralated macular degeneration in the Japanese population2011
- Author(s)
  Arakawa S, Kiyohara Y, Kubo M, Ishibashi T, et al
- Journal Title
  
  Nature genetics
  
  Volume: 43 Pages: 1001-1004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390468
[Journal Article] et al. Genome-wide association stud y identifies two susceptibility loci for exudative ageralated macular degeneration i n the Japanese population2011
- Author(s)
  Arakawa S, Kiyohara Y, Kubo M, Ishib ashi T
- Journal Title
  
  Nature genetics
  
  Volume: 43 Pages: 10001-1004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390468
[Journal Article] QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population : the Hisayama study.2010
- Author(s)
  Maebuchi D, Arima H, Doi Y, Ninomiya T, Yonemoto K, Tanizaki Y, Kubo M, Hata J, Matsumura K, Iida M, Kiyohara Y
- Journal Title
  
  Hypertens Res 33
  
  Pages: 916-921
- NAID
  10026711128
- Data Source
  KAKENHI-PROJECT-20591063
[Journal Article] Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke.2010
- Author(s)
  Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitazono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M
- Journal Title
  
  Hum Mol Genet 19
  
  Pages: 1137-1146
- Data Source
  KAKENHI-PROJECT-20591063
[Journal Article] The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population.2010
- Author(s)
  Hata J, Doi Y, Ninomiya T, Tanizaki Y, Yonemoto K, Fukuhara M, Kubo M, Kitazono T, Iida M, Kiyohara Y
- Journal Title
  
  Atherosclerosis 210
  
  Pages: 249-255
- Data Source
  KAKENHI-PROJECT-20591063
[Journal Article] Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population : the Hisayama Study.2010
- Author(s)
  Nagata M, Ninomiya T, Doi Y, Yonemoto K, Kubo M, Hata J, Tsuruya K, Iida M, Kiyohara Y
- Journal Title
  
  Nephrol Dial Transplant 25
  
  Pages: 2557-2564
- Data Source
  KAKENHI-PROJECT-20591063
[Journal Article] Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population.2010
- Author(s)
  Matsushita T, Umeno J, Hirakawa Y, Yonemoto K, Ashikawa K, Amitani H, Ninomiya T, Hata J, Doi Y, Kitazono T, Iida M, Nakamura Y, Kiyohara Y, Kubo M
- Journal Title
  
  J Hum Genet 55
  
  Pages: 473-476
- NAID
  10030736001
- Data Source
  KAKENHI-PROJECT-20591063
[Journal Article] Soluble Flt-1 gene transfer ameliorates neointima formation after wire injury in flt-1 tyrosine kinase deficient mice2009
- Author(s)
  Koga J, Matoba T, Egashira K, Kubo M, Miyagawa M, Iwata E, Sueishi K, Shibuya M, Sunagawa K
- Journal Title
  
  Arterioscler Thromb Vasc Biol 29(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Journal Article] Lack of association between variations of PDE4D and ischemic stroke in the Japanese population.2009
- Author(s)
  Matsushita T, Kubo M, Yonemoto K, Ninomiya T, Ashikawa K, Liang B, Hata J, Doi Y, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y
- Journal Title
  
  Stroke 40
  
  Pages: 1245-1251
- Data Source
  KAKENHI-PROJECT-20591063
[Journal Article] LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population : the Hisayama study.2009
- Author(s)
  Imamura T, Doi Y, Arima H, Yonemoto K, Hata J, Kubo M, Tanizaki Y, Ibayashi S, Iida M, Kiyohara Y
- Journal Title
  
  Stroke 40
  
  Pages: 382-388
- Data Source
  KAKENHI-PROJECT-20591063
[Journal Article] Hyperglycemia increases risk of gastric cancer posed by Helicobacter pylori infection : a population-based cohort study.2009
- Author(s)
  Ikeda F, Doi Y, Yonemoto K, Ninomiya T, Kubo M, Shikata K, Hata J, Tanizaki Y, Matsumoto T, Iida M, Kiyohara Y
- Journal Title
  
  Gastroenterology 136
  
  Pages: 1234-1241
- Data Source
  KAKENHI-PROJECT-20591063
[Journal Article] Proposed criteria for metabolic syndrome in Japanese based on prospective evidence : the Hisayama study.2009
- Author(s)
  Doi Y, Ninomiya T, Hata J, Yonemoto K, Arima H, Kubo M, Tanizaki Y, Iwase M, Iida M, Kiyohara Y
- Journal Title
  
  Stroke 40
  
  Pages: 1187-1194
- Data Source
  KAKENHI-PROJECT-20591063
[Journal Article] High-sensitive C-reactive protein and coronary heart disease in a general polpulation of Japanese: the Hisayama study2008
- Author(s)
  Arima H, Kubo M, Yonemoto K, Doi, Nimomiya T, Tanizaki Y,Hata J, Matsumura K, Iida M, Kiyohara Y
- Journal Title
  
  Arterioscler Thromb Vasc Biol 28
  
  Pages: 1385-1391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Journal Article] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations2008
- Author(s)
  Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DP, Holmkvist J, Borch-Johnsen K, Jorgensen T, Sandbak A, Lauritzen T, Hansen T, Nurbaya S, Tsunoda T, Kubo M, Babazono T, Hirose H, Hayashi M, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Tai ES, Pedersen O, Kamatani N, Kadowaki T, Kikkawa R, Nakamura Y, Maeda S
- Journal Title
  
  Nat Genet 40
  
  Pages: 1098-1102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Journal Article] Impact of metabolic syndrome on the development of cardiovascular disease in general Japanes population: the Hisayama study2008
- Author(s)
  Ninomiya T, Kubo M, Doi Y, Yonemoto K, Tanizaki Y, Rahman M, Arima H, Tsuruya K, Iida M, Kiyohara Y
- Journal Title
  
  Stroke 38
  
  Pages: 2063-2069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Journal Article] Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population2008
- Author(s)
  Doi Y, Kubo M, Yonemoto K, Ninomiya T, Iwase M, Arima H, Hata J, Tanizaki Y, Iida M, Kiyohara Y
- Journal Title
  
  J Clin Endocrinol Metab 93
  
  Pages: 3425-3429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Journal Article] Secular trends in the incidence of and risk factors for ischemic stroke and its subtypes in Japanese population2008
- Author(s)
  Kubo M, Hata J, Doi Y, Tanizaki Y, Iida M, Kiyohara Y
- Journal Title
  
  Circulation 118
  
  Pages: 2672-2678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Journal Article] Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction2007
- Author(s)
  Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y, Kubo M
- Journal Title
  
  Hum Mol Genet 16
  
  Pages: 630-639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Journal Article] A nonsynonymous SNP in PRKCH (proteinkinase C η) increases the risk of cerebral infarction2007
- Author(s)
  Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y
- Journal Title
  
  Nature Genetics 39(2)
  
  Pages: 212-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Journal Article] A nonsynonymous SNP in PRKCH(protein kinase Cη)increases the risk of cerebral infarction2007
- Author(s)
  Kubo M
- Journal Title
  
  Nature Genetics 39
  
  Pages: 212-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Journal Article] Development of immunostimulatory virotherapy using non-transmissible Sendai virus -activated dendritic cells2007
- Author(s)
  Yoneyama Y, Ueda Y, Akutsu Y, Matunaga A, Shimada H, Kato T, Kubota-Akizawa M, Okano S, Shibata S, Sueishi K, Hasegawa M, Ochiai T, Yonemitsu Y
- Journal Title
  
  Biochem Biophys Res Commun 355(1)
  
  Pages: 129-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Journal Article] Prehypertension increases the risk for renal arteriosclerosis in autopsies : The Hisayama Study2007
- Author(s)
  Ninomiya T, Kubo M, Doi Y, Yomemoto K, Tanizaki Y, Tsuruya K, Sueishi K, Tsuneyoshi M, Iida M, Kiyohara Y
- Journal Title
  
  J Am Soc Nephrol 18
  
  Pages: 2135-2142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Journal Article] Prospective cohort study of the risk of prostate cancer among rotating-shift workers : Findings from the Japan Collaborating Cohort Study2006
- Author(s)
  Kubo T
- Journal Title
  
  Am J Epidemiol 164
  
  Pages: 549-555
- Data Source
  KAKENHI-PROJECT-17015018
[Journal Article] Risk factors for coronary atherosclerosis in a general Japapnese population
- Author(s)
  Nakashima Y, Kiyohara Y, Doi Y, Kubo M, Iida M, Sueishi K
- Journal Title
  
  The Hisayama study. Pathol Res Pract (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209012
[Patent] 一塩基多型に基づく前立腺癌の検査方法2011
- Inventor(s)
  中川英刀、久保充明、高橋篤、赤松秀輔、高田亮、小川修、中村祐輔
- Industrial Property Number
  2011-019051
- Filing Date
  2011-01-31
- Data Source
  KAKENHI-PROJECT-22390306
[Presentation] 2 型糖尿病患者における食物繊維摂取量と肥満関連遺伝子との相互作用の検討　Fukuoka Diabetes Registry2016
- Author(s)
  岩瀬正典,藤井裕樹,中村宇大,大隈俊明,筒信隆,布井清秀,五島大祐,野原栄,篠原規恭,南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,市川晃治郎,久保充明,北園孝成
- Organizer
  第19回日本病態栄養学会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-01-09
- Data Source
  KAKENHI-PROJECT-23249037
[Presentation] 痛風のゲノムワイド関連解析：新規遺伝子座の同定とコンパニオン診断の可能性2016
- Author(s)
  松尾洋孝, 山本健, 中岡博史, 中山昌喜, 崎山真幸, 中村好宏, 中島宏, 小縣開, 銀光, 岡田理恵子, 森田えみ, 内藤真理子, 櫻井裕, 細谷龍男, 浜島信之, 井ノ上逸朗, 久保充明, 大山博司, 清水徹, 四ノ宮成祥
- Organizer
  第26回日本疫学会学術総会
- Place of Presentation
  米子コンベンションセンター（鳥取県米子市）
- Year and Date
  2016-01-21
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] BRCA-1関連タンパク質（BRAP）遺伝子多型とメタボリックシンドロームとの関連：J-MICC Study2016
- Author(s)
  藤井亮輔, 近藤高明, 上山純, 林由美, 浜島信之, 内藤真理子, 若井建志, 久保充明, 田中英夫
- Organizer
  第26回日本疫学会学術総会
- Place of Presentation
  米子コンベンションセンター（鳥取県米子市）
- Year and Date
  2016-01-21
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] 2 型糖尿病患者の血糖レベルに対する環境-遺伝相互作用：福岡県糖尿病患者データベース2015
- Author(s)
  大隈俊明,岩瀬正典,中村宇大,藤井裕樹,井手均,筒信隆,布井清秀,野原栄,五島大祐,篠原規恭,南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,久保充明,北園孝成
- Organizer
  第53回日本糖尿病学会九州地方会
- Place of Presentation
  福岡市
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-23249037
[Presentation] アルデヒド分解酵素遺伝子多型と大血管合併症との関連福岡県糖尿病患者データベース研究2015
- Author(s)
  井手脇康裕,岩瀬正典,中村宇大,藤井裕樹,筒信隆,布井清秀,五島大祐,野原栄,篠原規恭,南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,市川晃治郎,久保充明,北園孝成
- Organizer
  第53回日本糖尿病学会九州地方会
- Place of Presentation
  福岡市
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-23249037
[Presentation] 2型糖尿病患者の血糖レベルに対する環境因子と遺伝因子の相互作用: Fukuoka Diabetes Registry 142015
- Author(s)
  大隈俊明,岩瀬正典,中村宇大,藤井裕樹,井手均,城臺環,海津梓奈子,菊池洋平,井手脇康裕,筒信隆,布井清秀,野原栄,五島大祐,篠原規恭,南昌江,和田美也,横溝由史,菊池正統,久保充明,北園孝成
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口県下関市
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-23249037
[Presentation] 2 型糖尿病患者における肥満遺伝子と食物繊維の相互作用福岡県糖尿病患者データベース2015
- Author(s)
  藤井裕樹,岩瀬正典,中村宇大,大隈俊明,筒信隆,布井清秀,五島大祐,野原栄,篠原規恭,南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,市川晃治郎,久保充明,北園孝成
- Organizer
  第53回日本糖尿病学会九州地方会
- Place of Presentation
  福岡市
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-23249037
[Presentation] インスリン分泌関連2型糖尿病疾患感受性遺伝子スコアとインスリン分泌能との関連に及ぼす臨床的因子の検討　福岡県糖尿病患者データベース研究(FDR10)2015
- Author(s)
  城臺環,岩瀬正典,中村宇大,藤井裕樹,大隈俊明,井手均,海津梓奈子,菊池洋平,井手脇康裕,筒信隆,布井清秀,五島大祐,野原栄,篠原規恭,南昌江,和田美也,横溝由史,菊池正統,久保充明,北園孝成
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口県下関市
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-23249037
[Presentation] 都市部と離島におけるcardio-ankle vascular index（CAVI）値および動脈硬化性疾患の危険因子の比較検討2015
- Author(s)
  桑原和代、杉山大典、平田匠、久保田芳美、西田陽子、東山綾、中畑典子、新村英士、嶽崎俊郎、若林一郎、岡村智教
- Organizer
  第47回日本動脈硬化学会総会・学術集会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] Matrix metalloproteinase-9 gene polymorphism is associated with family history of gastric cancer: from the J-MICC Study2015
- Author(s)
  Okada R, Naito M, Suma S, Kawai S, Hishida A, Morita E, Hamajima N, Kubo M, Tanaka H, Wakai K, J-MICC Study Group
- Organizer
  The 74th Annual Meeting of the Japanese Cancer Association（第74回日本癌学会学術総会）
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] Interactions of lifestyle and diabetes susceptibility genes on glycemic control in patients with type 2 diabetes mellitus: Fukuoka Diabetes Registry2015
- Author(s)
  大隈俊明,岩瀬正典,中村宇大,藤井裕樹,井手均,城臺環,海津梓奈子,菊池洋平,井手脇康裕,筒信隆,布井清秀,野原栄,五島大祐,篠原規恭,南昌江,和田美也,横溝由史,菊池正統,久保充明,北園孝成
- Organizer
  The 2nd Japan-Korea Diabetes Forum
- Place of Presentation
  山口県下関市
- Year and Date
  2015-05-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23249037
[Presentation] ２型糖尿病患者におけるAldehyde dehydrogenase多型と糖尿病腎症との関連　福岡県糖尿病患者データベース研究：FukuokaDiabetesRegistry52015
- Author(s)
  井手脇康裕,岩瀬正典,中村宇大,藤井裕樹,大隈俊明,海津梓奈子,井手均,城臺環,菊池洋平,筒信隆,布井清秀,五島大祐,野原栄,篠原規恭,南昌江,和田美也,横溝由史,菊池正統,久保充明,北園孝成
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口県下関市
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-23249037
[Presentation] 糖尿病関連遺伝子の疫学：久山町研究2012
- Author(s)
  土井康文，久保　充明，清原　裕
- Organizer
  第57回日本人類遺伝学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24590797
[]

1. KIYOHARA Yutaka (80161602)

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2. DOI Yasufumi (00419566)

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38. NAKAGATA Naomi (30159058)

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39. TOYOKUNI Shinya (90252460)

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KUBO Michiaki 久保 充明

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[Journal Article] Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer2016

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[Journal Article] Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure2016

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[Journal Article] "Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population"2016

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[Journal Article] Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men2015

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[Journal Article] Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols.2015

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KUBO Michiaki 久保充明