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Saya Hideyuki  佐谷 秀行

… Alternative Names

SAYA Hideyuki  佐谷 秀行

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Researcher Number 80264282
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-6610-1902
External Links
Affiliation (Current) 2025: 藤田医科大学, 橋渡し研究シーズ探索センター, センター長
2025: 藤田医科大学, 腫瘍医学研究センター, センター長
Affiliation (based on the past Project Information) *help 2025: 藤田医科大学, 腫瘍医学研究センター, センター長
2024 – 2025: 藤田医科大学, 橋渡し研究シーズ探索センター, センター長
2022 – 2024: 藤田医科大学, がん医療研究センター, センター長
2023: 藤田医科大学, 腫瘍医学研究センター, センター長
2022: 慶應義塾大学, 医学部(信濃町), 名誉教授 … More
2017 – 2021: 慶應義塾大学, 医学部(信濃町), 教授
2017: 慶応大学, 医学部, 教授
2017: 慶應義塾大学, 医学部, 教授
2006 – 2015: Keio University, School of Medicine, Professor, 医学部, 教授
2010 – 2011: 慶応義塾大学, 医学部, 教授
2009: 慶應義塾大学, 医学部
2008: 慶応義塾大学, 医学部, 教授
2006: 慶應大学, 医学部先端医科学研究所, 教授
2005 – 2006: 熊本大学, 生命資源研究支援センター, センター長
2003 – 2006: Kumamoto University, Graduate School of Medical Sciences, Tumor Genetics & Biology, Professor, 大学院・医学薬学研究部, 教授
2005: 熊本大学, 大学院医学薬学研究部, 教授
2004: 熊本大学, 生命資源研究・支援センター, センター長
1994 – 2002: Kumamoto Univ.School of Medicine, 医学部, 教授 Less
Review Section/Research Field
Principal Investigator
Cerebral neurosurgery / Cerebral neurosurgery / Medium-sized Section 50:Oncology and related fields / Pathological medical chemistry / Tumor biology / Tumor biology / Biological Sciences / Experimental pathology / Pathological medical chemistry / Neurosurgery / Biological Sciences … More
Except Principal Investigator
… More Cerebral neurosurgery / Basic Section 57060:Surgical dentistry-related / Cerebral neurosurgery / Biological Sciences / Pathological medical chemistry / Gastroenterology / Pathobiological dentistry/Dental radiology / Dermatology / Basic Section 56010:Neurosurgery-related / Basic Section 56030:Urology-related / Basic Section 54010:Hematology and medical oncology-related / Respiratory organ internal medicine / Neurosurgery / Pediatric surgery / Respiratory organ internal medicine / Urology / Clinical oncology / Biological Sciences / Experimental pathology Less
Keywords
Principal Investigator
癌 / 細胞・組織 / CD44 / 脳腫瘍 / 遺伝子 / 細胞周期 / 細胞分裂 / チェックポイント / メタロプロテアーゼ / グリオーマ … More / がん微小環境 / APC / 腫瘍微小環境 / 腫瘍関連線維芽細胞 / アクチン / MKL1 / がん関連線維芽細胞 / 発生・分化 / シグナル伝達 / Cdh1 / WARTS / 細胞死 / 分裂期キナーゼ / p27 / DT40 / Rac / NE-dlg / warts / 癌関連線維芽細胞 / アクチン細胞骨格 / ヒアルロン酸 / 接着分子 / checkpoint / p51-nedasin / EST / バイオテクノロジー / 抗癌剤 / 分化 / 脂肪細胞 / 骨肉腫 / 低分子化合物 / 幹細胞 / 病理学 / 細胞運動 / アポトーシス / DT40細胞 / Aurora-A / 遺伝子破壊 / サイクリンA / HCT1 / Ras / Rho / カルシウムイオノフォア / E-カドヘリン / 1(3)mbt / ショウジョウバエ / 発現クローニング / p53遺伝子 / PARP / NF2 / メチオニン / 活性酸素 / 治療抵抗性がん / 治療抵抗性 / フェロトーシス / ALDH / xCT / レドックス制御 / メチオニン代謝 / シスチントランスポーター / 難治がん / Benzaldehyde / benzaldehyde / ベンズアルデヒド / 14-3-3ζ / Rhoキナーゼ阻害剤 / 微小環境 / MKL / 動物モデル / 急性リンパ芽球性白血病 / 卵巣がん / 腫瘍免疫 / がん幹細胞 / Invasion / Drug resistance / Adhesion molecule / Mitosis / Brain / Cell / Gene / Cancer / 酸化ストレス / 抗がん剤 / 薬剤耐性 / 生体分子 / 脳・神経 / cancer / DNA damage / mitosis / anti-tumor agents / chemoresistance / mitotic catastrophe / brain tumor / 薬剤抵抗件 / DNA損傷 / 薬剤抵抗性 / 分裂期崩壊 / invasion / hyaluronic acid / cadherin / γ-secretase / transcription / metalloprotease / adhesion molecule / 癌浸潤 / カドヘリン / γ-セクレターゼ / 転写制御 / mitotic kinases / rapamycin / fzr遺伝子 / anaphase promoting complex (APC) / ラパマイシン / Polycomb / calmodulin / synapse / Drosophila / P-dlg / PDZドメイン / NMDAレセプター / DLG / ポリコーム / カルモジュリン / シナプス / l(3)mbt / p51-neasin / NDP kinase / bcl-2 gene / p53 gene / apoptosis / glioma / アデノウイルス / EBNA-1 / Bcl-2遺伝子 / NDPキナーゼ / Bc1-2遺伝子 / 代謝 / 増殖 / 細胞 / マクロファージ / IGF / 癌幹細胞 / 発がん / 癌遺伝子 / 癌モデル生物 / トランスジェニックメガタ / クロマチン / 老化 / 細胞表面マーカー / フローサイトメトリー / 三次元培養 / マトリクス / 乳腺 / 前立腺 / 細胞老化 / 遺伝子改変マウス / オーロラキナーゼ / リン酸化 / タンパク分解 / 蛋白質 / タンパク質分解 / 細胞骨格 / p53 / Cre-loxP / トランスジェニックマウス / RNAi / ADAM17 / ADAM10 / 細胞接着 / U87MG / ノコダゾール / ドミナントネガティブ / 分裂期チェックポイント / mad2 / Smad / TGFβ / zyxin / cdc2 / 細胞質分離 / anaphase promoting complex(APC) / PP2A / LIM kinase-a / Omi / p57 / Ajuba / CENP-A / LIM kinase / p21 / WGEF / サイクリンB / fzr / TPA / 浸潤 / 細胞外ドメイン / カルシウム / β-カテニン / NEURL / カルパイン / 6q25 / 神経系腫瘍 / 相同遺伝子 / 腫瘍抑制遺伝子 / 転写因子 / 酵母 / NF1 / dlg / neuralized / マイクロサテライト / 10番染色体 / 癌抑制遺伝子 … More
Except Principal Investigator
NF2 / CD44 / NF1 / Merlin / p53 / プロテオミクス / Neurofibromin / 口腔扁平上皮癌 / 腫瘍抑制遺伝子 / CD44v / Neurofibromatosis Type 2 / Ku-antigen / 神経線維腫症 / brain tumor / EMT / メダカ / 癌 / merlin / 神経線維腫症2型 / 口腔癌 / 遺伝子変異 / PDXモデル / グルタチオン / WARTS / Proteomics / Neurofibromatosis Type 1 / classification / prognosis / EGFR / p16 / gene analysis / malignant glioma / Poly (ADP-ribose) polymerase (PARP) / Tumor suppressor gene / poly(ADP-ribose)polymerase(PARP) / 脳腫瘍 / RB / siRNA / 腫瘍抑制シグナル / トランスクリプトーム / glioma / トランスジェニックメダカ / ノックアウト / トランスジェニック / 細胞・組織 / アポトーシス / ノックアウトマウス / 細胞内シグナル伝達 / 免疫逃避 / スプライシングアイソフォーム / CD47 / エクソソーム / ホウ素中性子捕捉療法 / RI創薬 / 術中蛍光造影 / インドシアニングリーン / 脳脊髄腫瘍 / スルファサラジン / copy number gain / short-read解析 / チロシンキナーゼ阻害薬 / 免疫チェックポイント / long-read解析 / 構造多型 / ネオアンチゲン / 腎細胞癌 / 網羅的遺伝子変異解析 / 微小残存病変 / 遺伝子変異解析 / 遺伝子異常 / 微少残存病変 / リキッドバイオプシー / 悪性リンパ腫 / CD44v / PDXマウスモデル / 口腔がん / 遺伝子パネル検査 / ブレオマイシン / 肺線維症マウスモデル / 肺胞上皮 / 上皮間葉転換 / 特発性肺線維症 / 1p19q / 画像 / 神経膠腫 / 1p/19q / image / neoadjuvant chemotherapy / Glioma / molecular classification / RGNT / personalized treatment / chemotherapy / neoadjuvant / MGMT / 1p/19q codeletion / ROS / 生体内イメージング / PET / 5-FU / がん幹細胞 / 胃がん / シスチン / trastuzumab / 胃癌幹細胞 / シスチントランスポーター / 酸化ストレス / CD44v9 / 肝芽腫 / 横紋筋肉腫 / 微小転移細胞 / 循環腫瘍細胞 / 腫瘍幹細胞 / 神経芽細胞腫 / 小児がん / 小児腫瘍学 / 小児外科学 / Latsl kinase / HtrA2 protease / Omi / 脾臓 / 胸腺 / mnd2マウス / Lats1キナーゼ / Omiプロテアーゼ / SiRNA / ノックダウン / 学習障害 / プロテミクス / リン酸化 / DNA-Pks / poly (ADP-ribose)polymerase (PARP) / 神経線維腫瘍2型 / DNA-PKs / poly (ADP-ribose) polymerase (PARP) / LOH 10 / 機能的解析 / 生存日数 / PTEN / LOH / 10番染色体 / グリオーマ / glioblastoma / LOH10 / Nuclear export signal (NES) / Cellular signal transduction / 神経繊維腫症2型 / NF2、 / nuclear export signal(NES) / Idiopathic interstitial pneumonia / Nitric oxide synthase / Lung cancer / NOS / 繊維化 / 特発生間質性肺炎 / 特発性間質性肺炎 / 一酸化窒素合成酵素 / 肺癌 / GST-fusion protein / anti-cancer drug / microsphere / Invasin / GST融合蛋白 / 抗癌剤 / マイクロスフィアー / invasin / COMPETITIVE RT-PCR / URINE / UROLOGIC CANCER / CD44遺伝子 / 泌尿器科癌 / Competitive RT-PCR / competitive RT-PCR / 尿 / 泌尿器癌 / chemokine / plasmid DNA / lac Z gene / MCP-1 / in vivo electroporation / electro-genetherapy (EGT) / hMCP1 / MCP-1遺伝子 / ケモカイン / human MCP-1遺伝子 / lacZ遺伝子 / プラスミドDNA / 生体内電気穿孔法 / 電気遺伝子療法 / Apoptosis / Differentiation / Trancefection / Expression Vector / Tumor Suppressor Gene / 分化誘導 / トランスフェクション / 発現ベクター / 癌抑制遺伝子 / ミトコンドリア呼吸 / 好気性解糖 / グルコース代謝 / 解糖系 / 既存薬 / 代謝変動 / pyruvate kinase M2 / 糖代謝 / 薬剤スクリーニング / RAS / HRAS高発現 / HRAS / メダカ腫瘍モデル / 抗癌剤スクリーニング / がん遺伝子導入メダカ / ステント / 超音波 / フリーラジカル / 金属ステント / 細胞運動 / 細胞骨格 / 消化器癌 / 浸潤・転移 / 大腸癌 / pathway解析 / 肝臓学 / 腫瘍生物学 / 実験腫瘍学 / 分子標的治療 / 幹細胞ニッチ / 癌幹細胞 / 生体分子 / 癌モデル生物 / 遺伝子導入 / 細胞分化 / 神経系腫瘍 / 脳腫瘍学 / 海馬 / cICAT / 2D-DICE / 虚血性アポトーシス / データマイニング / differential display / 臨床マーカー / 抗癌剤感受性 / 乏突起神経膠腫 / 性 / 外性器 / トランスジェニックマウス / マウス / 生殖腺 / 性分化異常 / モデル動物 / 性分化 / ウィルス / 細胞組織 / 遺伝子 / ゲノム / ウイルス / 遺伝学 / 遺伝子疾患モデルマウス / NE-dlg / 神経細胞 / 脳 / 虚血 / カイニン酸 / 細胞内会合タンパク質 / PARP / poly(ADP-ribose)polymerase / 2国間共同研究 / 2国間協同研究 / ヒトゲノム / がん転移 / DNA修復 / がん細胞 / シグナル伝達 / がん抑制遺伝子 / がん遺伝子 Less
  • Research Projects

    (73 results)
  • Research Products

    (309 results)
  • Co-Researchers

    (155 People)
  •  口腔癌のエクソソームとCD47スプライシングアイソフォームによる免疫逃避の解明

    • Principal Investigator
      莇生田 整治
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Keio University
  •  Development of a Novel Treatment Method Using Boron Radioisotope Compounds Targeting Brain and Spinal Cord Tumors

    • Principal Investigator
      武藤 淳
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Fujita Health University
  •  Elucidation of adipocyte-to-cancer-associated fibroblast conversion mechanism and establishment of strategies to control cancer microenvironmentPrincipal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Fujita Health University
  •  PDXモデルを用いた局所進行・再発転移口腔癌に対する新たな治療戦略の考案

    • Principal Investigator
      吉川 桃子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Keio University
  •  Identification of structual variants abd neoantigens of renal cell carcinoma uising long-read sequence analysis

    • Principal Investigator
      住友 誠
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Fujita Health University
  •  Actionable遺伝子変異に基づく新たな口腔扁平上皮癌治療戦略の開発

    • Principal Investigator
      莇生田 整治
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Keio University
  •  Evaluation of minimal residual disease by liquid biopsy in malignant lymphoma for precise therapeutic stratification.

    • Principal Investigator
      Tomita Akihiro
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Fujita Health University
  •  Elucidation of cancer treatment resistance mechanism based on methionine metabolism and identification of novel therapeutic targetsPrincipal Investigator

    • Principal Investigator
      Saya Hideyuki
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Fujita Health University
      Keio University
  •  Characterization of CD44v-positive oral cancer stem cells using PDX model and establishment of novel drug therapy

    • Principal Investigator
      Yoshikawa Momoko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Keio University
  •  Elucidation of the molecular mechanism of cancer-related fibroblast induction and regulation of the tumor microenvironment based on its inhibitionPrincipal Investigator

    • Principal Investigator
      Saya Hideyuki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Fujita Health University
      Keio University
  •  Identification of targetable genetic mutations and establishment of personalized therapy in standard therapy-resistant oral squamous cell carcinoma

    • Principal Investigator
      Asoda Seiji
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Keio University
  •  Development of new therapeutic agents for pancreatic cancer targeting 14-3-3dzetaPrincipal Investigator

    • Principal Investigator
      Saya Hideyuki
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Keio University
  •  Elucidation of underlyingmechanism of MKL1-mediated induction of cancer associated fibroblasts and its clinical applicationsPrincipal Investigator

    • Principal Investigator
      Saya Hideyuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Tumor biology
    • Research Institution
      Keio University
  •  Analysis of escaping mechanism from immune system by microenvironment of cancer stem cellsPrincipal Investigator

    • Principal Investigator
      Saya Hideyuki
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor biology
    • Research Institution
      Keio University
  •  Towards personalized treatment of diffuse gliomas based on molecular characteristics

    • Principal Investigator
      SASAKI HIKARU
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Keio University
  •  EMT inhibitor for the treatment of idiopathic pulmonary fibrosis

    • Principal Investigator
      Takahashi Fumiyuki
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Juntendo University
  •  Development of a novel anti-invasion therapy targeting the glioma stem cell/endothelial cell invasion complexPrincipal Investigator

    • Principal Investigator
      Saya Hideyuki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurosurgery
    • Research Institution
      Keio University
  •  The applied strategic research for the sake of cancer treatment; the discovery of puruvate kinase M2 (PKM2) activator out of existing drugs

    • Principal Investigator
      TAMADA Mayumi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Keio University
  •  Treatment sensitivity evaluation of oral squamous cell carcinoma based on the expression of a functional cancer stem cell marker CD44v

    • Principal Investigator
      Asoda Seiji
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Keio University
  •  Basic study for the development of PET diagnosis specific for CD44 variant-positive gastric cancer stem like cells

    • Principal Investigator
      Suzuki Hidekazu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  A novel prevention method for re-obstruction using titanium alloy stent with ultrasonic irradiation

    • Principal Investigator
      ITANO Osamu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Clinical oncology
    • Research Institution
      Keio University
  •  Establishment of transgenic HRAS medaka as a tumor model for in vivo drug screening

    • Principal Investigator
      MATSUZAKI Yuriko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Biological characterization of pediatric cancer stem cell, CTC, and DTC

    • Principal Investigator
      Kuroda Tatsuo
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatric surgery
    • Research Institution
      Keio University
  •  The role of cell cycle regulator Cdh1 in carcinogenesis and development of gastrointestinal cancer.

    • Principal Investigator
      NAOE Hideaki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kumamoto University
  •  Development of anti-metastatic strategy based on analysis of premetastatic nichePrincipal Investigator

    • Principal Investigator
      SAYA Hideyuki
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor biology
    • Research Institution
      Keio University
  •  Development of Novel Treatment Strategies Targeting Cancer Stem Cells

    • Principal Investigator
      AKASHI Koichi
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University
  •  Development of strategies to overcome therapeutic resistance by using induced cancer stem cells (iCSCs)Principal Investigator

    • Principal Investigator
      SAYA Hideyuki
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
  •  Development of new strategies to overcome glioblastoma invasiveness and drug-resistance using a glioma stem cell modelPrincipal Investigator

    • Principal Investigator
      SAYA Hideyuki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Keio University
  •  Study of the molecular mechanism of neural tumor formation mediatedby NF1 gene deficiency

    • Principal Investigator
      ARAKI Norie
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  New classification of oral squamous cell carcinoma based on the molecular expression profile controlling the epithelial mesenchymal transition and stem cell-like characteristics

    • Principal Investigator
      ASODA Seiji
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Keio University
  •  上皮間葉転換可視化システムを用いた癌浸潤転移阻害化合物スクリーニングPrincipal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor biology
    • Research Institution
      Keio University
  •  New melanoma model using transgenic medaka fish

    • Principal Investigator
      MATSUZAKI Yuriko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  遺伝子改変メダカを用いた分裂異常に基づく発癌モデルの構築Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Keio University
  •  Research for development of novel therapeutic approaches targeting molecules regulating invasion and drug resistance of malignant gliomasPrincipal Investigator

    • Principal Investigator
      SAYA Hideyuki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Keio University
  •  Analysis of cellular signal transduction via Neurofibromatosis tumor suppressor gene products and development of their clinical targets

    • Principal Investigator
      ARAKI Norie
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  細胞老化のリアルタイム解析法の確立とその応用による老化シグナルの解析Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Keio University
  •  脳神経系特異的な虚血性細胞死の分子シグナル制御機構の解明

    • Principal Investigator
      荒木 令江
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Analysis of serine protease Omi-mediated-signaling pathway which could affect both tumorigenesis and neurodegenerative disorder

    • Principal Investigator
      KUNINAKA Shinji
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Keio University
      Kumamoto University
  •  Analysis of role of mitotic regulation and its abnormalities in carcinogenesisPrincipal Investigator

    • Principal Investigator
      SAYA Hideyuki
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
      Kumamoto University
  •  生体内3D器官再構築システムを用いた細胞周期制御分子異常による腫瘍形成機構の解析Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kumamoto University
  •  プロテオミクス融合技術による乏突起神経膠腫の化学療法感受性メカニズムの解析

    • Principal Investigator
      荒木 令江
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Identification of molecules regulating resistance and invasiveness of malignant gliomas and development of new therapeutic approachesPrincipal Investigator

    • Principal Investigator
      SAYA Hideyuki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KEIO UNIVERSITY
      Kumamoto University
  •  Genetic and Epigenetic Dysregulation in Cancer

    • Principal Investigator
      NODA Tetsuo
    • Project Period (FY)
      2004 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Japanese Foundation For Cancer Research
      Tohoku University
  •  Reproduction and maintenance of experimental animals for the study of molecular mechanisms of sex differentiation

    • Principal Investigator
      SASAOKA Toshikuni, NAGAHAMA Yoshitaka, 勝木 元也
    • Project Period (FY)
      2004 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute for Basic Biology
  •  Aurora-Aキナーゼ過剰発現マウスによる悪性脳腫瘍発生モデルの作製Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Study for the cellular signal transduction of Neurofibromatosis Type 1 and Type 2 tumor suppressor gene products to establish the medical molecular target for NF1 and NF2

    • Principal Investigator
      ARAKI Norie
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  RNA干渉法(RNAi)を用いた脳腫瘍浸潤抑制のための標的分子同定Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Analysis of molecular mechanisms of chemoresistance in malignant glioma cellsPrincipal Investigator

    • Principal Investigator
      SAYA Hideyuki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Study on cellular signal transduction of Neurofibromatosis Type 1 and Type 2 tumor suppressor gene products

    • Principal Investigator
      ARAKI Norie
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  生体ストレスによる脳神経組織障害の発生メカニズムの解析--p53を介して誘導される脳神経系細胞死に関連するシグナル分子の検索--

    • Principal Investigator
      荒木 令江
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  細胞増殖の抑制とその破綻機構の解析Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  ヒト脳腫瘍細胞株を用いたin vitro遺伝子ターゲッティング-遺伝子変異と治療感受性の関連解析-Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Functional analysis of cell cycle regulators by in vitro gene targeting using DT40 cellsPrincipal Investigator

    • Principal Investigator
      SAYA Hideyuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kumamoto University
  •  Basic analysis for development of inhibitors of malignant glioma invasionPrincipal Investigator

    • Principal Investigator
      SAYA Hideyuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University School of Medicine
  •  Study on cellular signal transduction of Neurofibromatosis Type 2 tumor suppressor gene product (Merlin)

    • Principal Investigator
      ARAKI Norie
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University School of Medicine
  •  ヨーロッパなどががん研究先進国との研究交流

    • Principal Investigator
      黒木 登志夫
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Showa University
  •  脳神経系腫瘍形成・進展に関与する分子の同定とその機能解析Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kumamoto University
  •  細胞接着分子CD44の癌細胞における生物学的機能に関する日米協力研究Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kumamoto University
  •  In vitro遺伝子ノックアウトによる細胞周期制御分子の機能解析Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Kumamoto University
  •  CLASSIFICATION OF MALIGNANT GLIOMAS BY MOLECULAR GENETIC ANALYSIS TO DEVELOP RATIONAL THERAPY

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  細胞間接着蛋白E-カドヘリン分解制御による腫瘍細胞浸潤性の変化Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Kumamoto University
  •  Identification of the novel genes which regulated differentiation of neuronal tissues and the diseases caused by their defectsPrincipal Investigator

    • Principal Investigator
      SAYA Hideyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Investigation of correlation between pulmonary fibrosis and carcinogenesis : Analysis about expression of p53, CD44 and nitric oxide synthase(NOS).

    • Principal Investigator
      MATSUMOTO Mitsuhiro
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kumamoto University
  •  Analysis of cellular function of Neurofibromatosis Type 2 tumor suppressor gene product (Merlin)

    • Principal Investigator
      ARAKI Norie
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University School of Medicine
  •  脳神経系腫瘍発生に関与する癌抑制遺伝子の機能とその異常の解析Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  ショウジョウバエ神経系腫瘍抑制遺伝子のヒト相同遺伝子の同定とその機能解析Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  神経線維腫症2型遺伝子産物(Merlin)の神経系腫瘍形成抑制機構の解析‥ Merlinに対する細胞内結合タンパク質の同定、及びその構造と相互作用機構の解析‥

    • Principal Investigator
      荒木 令江
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Developement of a method for cancer treatment using invsin-conjugated microsphere

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  酵母発現システムを用いたp53蛋白の転写機能調節因子の同定Principal Investigator

    • Principal Investigator
      佐谷 秀行
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kumamoto University
  •  Functional analysis of p53-induced apoptosis in glioma cellsPrincipal Investigator

    • Principal Investigator
      SAYA Hideyuki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  DEVELOPMENT OF GENE TRANSFER METHOD FOR SOLID TUMORS USING IN VIVO ELECTROPORATION.

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  THE ANALYSIS OF CD44 ALTERNATIVE SPLICING PATTERN IN UROLOGIC CANCER

    • Principal Investigator
      MATUI Takashi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      KOBE UNIVERSITY
  •  Japan-US Collaborative studies on Tumor Suppressor Genes : Regulation of Cancer Cells by Modulating the Expression of Tumor Suppressor Genes.

    • Principal Investigator
      TAKAHASHI Rei
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Patent

  • [Journal Article] Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment2024

    • Author(s)
      Yonemura A、Semba T、Zhang J、Fan Y、Yasuda-Yoshihara N、Wang H、Uchihara T、Yasuda T、Nishimura A、Fu L、Hu X、Wei F、Kitamura F、Akiyama T、Yamashita K、Eto K、Iwagami S、Iwatsuki M、Miyamoto Y、Matsusaki K、Yamasaki J、Nagano O、Saya H、Song S、Tan P、Baba H、Ajani Jaffer A.、Ishimoto T
    • Journal Title

      Cell Reports

      Volume: 43 Issue: 1 Pages: 113613-113613

    • DOI

      10.1016/j.celrep.2023.113613

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K14572, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-23K08113, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23H00410, KAKENHI-PROJECT-23K27689
  • [Journal Article] Estimating copy number to determine BRCA2 deletion status and to expect prognosis in localized prostate cancer2023

    • Author(s)
      Nukaya Takuhisa、Sumitomo Makoto、Sugihara Eiji、Takeda Mayu、Nohara Sachio、Tanishima Shigeki、Takenaka Masashi、Zennami Kenji、Takahara Kiyoshi、Shiroki Ryoichi、Saya Hideyuki
    • Journal Title

      Cancer Medicine

      Volume: 12 Issue: 7 Pages: 8154-8165

    • DOI

      10.1002/cam4.5617

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07179, KAKENHI-PROJECT-22K09488
  • [Journal Article] 5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy2023

    • Author(s)
      Fukumura Masao、Nonoguchi Naosuke、Kawabata Shinji、Hiramatsu Ryo、Futamura Gen、Takeuchi Koji、Kanemitsu Takuya、Takata Takushi、Tanaka Hiroki、Suzuki Minoru、Sampetrean Oltea、Ikeda Naokado、Kuroiwa Toshihiko、Saya Hideyuki、Nakano Ichiro、Wanibuchi Masahiko
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 10173-10173

    • DOI

      10.1038/s41598-023-37296-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07177, KAKENHI-PROJECT-23H00410, KAKENHI-PROJECT-23K27715
  • [Journal Article] MEK inhibition suppresses metastatic progression of <i>KRAS</i> ‐mutated gastric cancer2022

    • Author(s)
      Yamasaki Juntaro、Hirata Yuki、Otsuki Yuji、Suina Kentaro、Saito Yoshiyuki、Masuda Kenta、Okazaki Shogo、Ishimoto Takatsugu、Saya Hideyuki、Nagano Osamu
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 3 Pages: 916-925

    • DOI

      10.1111/cas.15244

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K16315, KAKENHI-PROJECT-21H02766, KAKENHI-PROJECT-21K19416, KAKENHI-PROJECT-21K19417, KAKENHI-PROJECT-20K18174, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-21K19535
  • [Journal Article] Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors.2022

    • Author(s)
      T. Akiyama, T. Yasuda, T. Uchihara, N. Yasuda-Yoshihara, BJY. Tan, A. Yonemura, T. Semba, J. Yamasaki, Y. Komohara, K. Ohnishi, F. Wei, L. Fu, J. Zhang, F. Kitamura, K. Yamashita, K. Eto, S. Iwagami, H. Tsukamoto, T. Umemoto, M. Masuda, O. Nagano, Y. Satou, H. Saya, P. Tan, H. Baba, T. Ishimoto
    • Journal Title

      Cancer Res.

      Volume: 83 Issue: 5 Pages: 753-770

    • DOI

      10.1158/0008-5472.can-22-1890

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07370, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-21K19416, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
  • [Journal Article] Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis2022

    • Author(s)
      Uetaki Megumi、Onishi Nobuyuki、Oki Yoshinao、Shimizu Takatsune、Sugihara Eiji、Sampetrean Oltea、Watanabe Takashi、Yanagi Hisano、Suda Kiyoshi、Fujii Hiroya、Kano Koichiro、Saya Hideyuki、Nobusue Hiroyuki
    • Journal Title

      Molecular Biology of the Cell

      Volume: 33 Issue: 9

    • DOI

      10.1091/mbc.e21-12-0609

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07131, KAKENHI-PROJECT-22K07177, KAKENHI-PROJECT-22K07179, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-20K07600
  • [Journal Article] Pigment epithelium-derived factor promotes peritoneal dissemination of ovarian cancer through induction of immunosuppressive macrophages2022

    • Author(s)
      Ueno Sayaka、Sudo Tamotsu、Saya Hideyuki、Sugihara Eiji
    • Journal Title

      Communications Biology

      Volume: 5 Issue: 1 Pages: 904-919

    • DOI

      10.1038/s42003-022-03837-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07179, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-21K19416
  • [Journal Article] Depletion of R270C Mutant p53 in Osteosarcoma Attenuates Cell Growth but Does Not Prevent Invasion and Metastasis In Vivo2022

    • Author(s)
      Shimizu Takatsune、Sugihara Eiji、Takeshima Hideyuki、Nobusue Hiroyuki、Yamaguchi Rui、Yamaguchi-Iwai Sayaka、Fukuchi Yumi、Ushijima Toshikazu、Muto Akihiro、Saya Hideyuki
    • Journal Title

      Cells

      Volume: 11 Issue: 22 Pages: 3614-3614

    • DOI

      10.3390/cells11223614

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07131, KAKENHI-PROJECT-21K07134, KAKENHI-PROJECT-22K07179, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00518
  • [Journal Article] Tumor-specific inter-endothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness2022

    • Author(s)
      Ando T, Tai-Nagara I, Sugiura Y, Kusumoto D, Okabayashi K, Kido Y, Sato Kohji, Saya H, Navankasattusas S, Li DY, Suematsu M, Kitagawa Y, Seiradake E, Yamagishi S, *Kubota Y.
    • Journal Title

      J Clin Invest

      Volume: 132 Issue: 6 Pages: 153626-153626

    • DOI

      10.1172/jci153626

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07389, KAKENHI-PROJECT-19K08549, KAKENHI-PROJECT-20K21499, KAKENHI-PROJECT-22K06915, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-23K21369
  • [Journal Article] Interleukin-6-derived cancer-associated fibroblasts activate STAT3 pathway contributing to gemcitabine resistance in cholangiocarcinoma2022

    • Author(s)
      Kittirat Yingpinyapat、Suksawat Manida、Thongchot Suyanee、Padthaisong Sureerat、Phetcharaburanin Jutarop、Wangwiwatsin Arporn、Klanrit Poramate、Sangkhamanon Sakkarn、Titapun Attapol、Loilome Watcharin、Saya Hideyuki、Namwat Nisana
    • Journal Title

      Frontiers in Pharmacology

      Volume: 13 Pages: 897368-897368

    • DOI

      10.3389/fphar.2022.897368

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H00518
  • [Journal Article] Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer2022

    • Author(s)
      Tsuchihashi Kenji、Hirata Yuki、Yamasaki Juntaro、Suina Kentaro、Tanoue Kenro、Yae Toshifumi、Masuda Kenta、Baba Eishi、Akashi Koichi、Kitagawa Yuko、Saya Hideyuki、Nagano Osamu
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 30 Pages: 101246-101246

    • DOI

      10.1016/j.bbrep.2022.101246

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-21H02766, KAKENHI-PROJECT-20K07638, KAKENHI-PROJECT-21K19417, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20K18174
  • [Journal Article] N-cadherin upregulation mediates adaptive radioresistance in glioblastoma2021

    • Author(s)
      Osuka Satoru、Zhu Dan、Zhang Zhaobin、Li Chaoxi、Stackhouse Christian T.、Sampetrean Oltea、Olson Jeffrey J.、Gillespie G. Yancey、Saya Hideyuki、Willey Christopher D.、Van Meir Erwin G.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 131 Issue: 6

    • DOI

      10.1172/jci136098

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07671, KAKENHI-PROJECT-20H00518
  • [Journal Article] Oncogenic KRAS?expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice2021

    • Author(s)
      Kasuga Akiyoshi、Semba Takashi、Sato Ryo、Nobusue Hiroyuki、Sugihara Eiji、Takaishi Hiromasa、Kanai Takanori、Saya Hideyuki、Arima Yoshimi
    • Journal Title

      Cancer Science

      Volume: 印刷中 Issue: 5 Pages: 1822-1838

    • DOI

      10.1111/cas.14703

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08968, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07243
  • [Journal Article] The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis2021

    • Author(s)
      Takeuchi Yasuto、Kimura N、Murayama T、Machida Y、Iejima D、Nishimura T、Terashima M、Wang Y、Li M、Sakamoto R、Yamamoto M、Itano N、Inoue Y、Ito M、Yoshida N、Inoue J、Akashi K、Saya H、Fujita K、Kuroda M、Kitabayashi I、Voon D、Suzuki Takeshi、Tojo A、Gotoh Noriko
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 43 Pages: 1-12

    • DOI

      10.1073/pnas.2103658118

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07346, KAKENHI-PROJECT-19K22557, KAKENHI-PUBLICLY-20H05029, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-21H02706, KAKENHI-PROJECT-21H02761, KAKENHI-PROJECT-20K07610, KAKENHI-PROJECT-21K15501, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-18K06671
  • [Journal Article] TGFβ Signaling Activated by Cancer-Associated Fibroblasts Determines the Histological Signature of Lung Adenocarcinoma2021

    • Author(s)
      Sato Ryo、Imamura Kosuke、Semba Takashi、Tomita Yusuke、Saeki Sho、Ikeda Koei、Komohara Yoshihiro、Suzuki Makoto、Sakagami Takuro、Saya Hideyuki、Arima Yoshimi
    • Journal Title

      Cancer Research

      Volume: 81 Issue: 18 Pages: 4751-4765

    • DOI

      10.1158/0008-5472.can-20-3941

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-20K08968, KAKENHI-PROJECT-21K19416
  • [Journal Article] MEK inhibition preferentially suppresses anchorage‐independent growth in osteosarcoma cells and decreases tumors in vivo2021

    • Author(s)
      Shimizu Takatsune、Kimura Kiyomi、Sugihara Eiji、Yamaguchi‐Iwai Sayaka、Nobusue Hiroyuki、Sampetrean Oltea、Otsuki Yuji、Fukuchi Yumi、Saitoh Kaori、Kato Keiko、Soga Tomoyoshi、Muto Akihiro、Saya Hideyuki
    • Journal Title

      Journal of Orthopaedic Research

      Volume: - Issue: 12 Pages: 2732-2743

    • DOI

      10.1002/jor.25023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07243, KAKENHI-PROJECT-18K07247, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-21K07131
  • [Journal Article] Lactate Reprograms Energy and Lipid Metabolism in Glucose-Deprived Oxidative Glioma Stem Cells2021

    • Author(s)
      Minami Noriaki、Tanaka Kazuhiro、Sasayama Takashi、Kohmura Eiji、Saya Hideyuki、Sampetrean Oltea
    • Journal Title

      Metabolites

      Volume: 11 Issue: 5 Pages: 325-325

    • DOI

      10.3390/metabo11050325

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07671, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-20K09369, KAKENHI-PROJECT-20K09389, KAKENHI-PROJECT-21K19416, KAKENHI-PLANNED-18H05463
  • [Journal Article] Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer2021

    • Author(s)
      Kenichi Miyata, Yoshinori Imai, Satoshi Hori, Mika Nishio, Tze Mun Loo, Ryo Okada, Liying Yang, Tomoyoshi Nakadai, et. al.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 118 Issue: 35

    • DOI

      10.1073/pnas.2025647118

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07651, KAKENHI-PROJECT-20K21555, KAKENHI-PROJECT-20K16163, KAKENHI-PUBLICLY-20H04789, KAKENHI-PLANNED-20H05940, KAKENHI-PROJECT-18H04034, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-19J00796, KAKENHI-PROJECT-21K19416, KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H05686, KAKENHI-PROJECT-19H03507
  • [Journal Article] The Inhibitor of Apoptosis Protein Livin Confers Resistance to Fas-Mediated Immune Cytotoxicity in Refractory Lymphoma2020

    • Author(s)
      Sugihara Eiji、Hashimoto Norisato、Osuka Satoru、Shimizu Takatsune、Ueno Sayaka、Okazaki Shogo、Yaguchi Tomonori、Kawakami Yutaka、Kosaki Kenjiro、Sato Taka-Aki、Okamoto Shinichiro、Saya Hideyuki
    • Journal Title

      Cancer Research

      Volume: 80 Issue: 20 Pages: 4439-4450

    • DOI

      10.1158/0008-5472.can-19-3993

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K16315, KAKENHI-PROJECT-19K24054, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07224, KAKENHI-PROJECT-18K07247
  • [Journal Article] Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d2020

    • Author(s)
      Semba Takashi、Sato Ryo、Kasuga Akiyoshi、Suina Kentaro、Shibata Tatsuhiro、Kohno Takashi、Suzuki Makoto、Saya Hideyuki、Arima Yoshimi
    • Journal Title

      Cancers

      Volume: 12 Issue: 12 Pages: 3805-3805

    • DOI

      10.3390/cancers12123805

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08968, KAKENHI-PROJECT-20H00518
  • [Journal Article] Blood and lymphatic systems are segregated by the FLCN tumor suppressor2020

    • Author(s)
      Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Liu C, Li W, Mukouyama Y, Linehan WM, Liu X, Hirashima M, Suzuki Y, Funasaki S, Satou Y, Furuya M, Baba M, Kubota Y.
    • Journal Title

      Nat. Commun.

      Volume: 11 Issue: 1 Pages: 6314-6314

    • DOI

      10.1038/s41467-020-20156-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07430, KAKENHI-PUBLICLY-19H04791, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-19H03397, KAKENHI-PROJECT-20H03724, KAKENHI-PROJECT-20K07395, KAKENHI-PROJECT-19K16696, KAKENHI-PROJECT-18KK0230, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H04003
  • [Journal Article] Molecular and cellular mechanisms underlying brain metastasis of breast cancer2020

    • Author(s)
      Hosonaga Mari、Saya Hideyuki、Arima Yoshimi
    • Journal Title

      Cancer and Metastasis Reviews

      Volume: 39 Issue: 3 Pages: 711-720

    • DOI

      10.1007/s10555-020-09881-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08968, KAKENHI-PROJECT-20H00518
  • [Journal Article] 2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche2020

    • Author(s)
      Koike Naoyoshi、Kota Ryuichi、Naito Yoshiko、Hayakawa Noriyo、Matsuura Tomomi、Hishiki Takako、Onishi Nobuyuki、Fukada Junichi、Suematsu Makoto、Shigematsu Naoyuki、Saya Hideyuki、Sampetrean Oltea
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 450-462

    • DOI

      10.1038/s42003-020-01165-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07671, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-20K16801, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07771
  • [Journal Article] Targeting of cancer stem cells by differentiation therapy2020

    • Author(s)
      Arima Yoshimi、Nobusue Hiroyuki、Saya Hideyuki
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 8 Pages: 2689-2695

    • DOI

      10.1111/cas.14504

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08968, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07243
  • [Journal Article] The insulin-PI3K-Rac1 axis contributes to terminal adipocyte differentiation through regulation of actin cytoskeleton dynamics2020

    • Author(s)
      Kunitomi H, Oki Y, Onishi N, Kano K, Banno K, Aoki D, Saya H, Nobusue H
    • Journal Title

      Genes to Cells

      Volume: 25 Issue: 3 Pages: 165-174

    • DOI

      10.1111/gtc.12747

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07243, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-19K06444
  • [Journal Article] Rock inhibition suppresses osteosarcoma tumorigenesis by inducing terminal adipocyte differentiation in chemoresistant stemlike cells2019

    • Author(s)
      1.Takahashi N, Nobusue H, Shimizu T, Sugihara E, Yamaguchi-Iwai S, Onishi N, Kunitomi H, Kuroda T, Saya H
    • Journal Title

      Cancer Research

      Volume: in press Issue: 12 Pages: 3088-3099

    • DOI

      10.1158/0008-5472.can-18-2693

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07247, KAKENHI-PROJECT-16J40108, KAKENHI-PROJECT-18K07224, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H04355, KAKENHI-PROJECT-16H06276
  • [Journal Article] Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.2018

    • Author(s)
      Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H.
    • Journal Title

      Nat Med.

      Volume: 24 Issue: 10 Pages: 1579-1589

    • DOI

      10.1038/s41591-018-0140-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09778, KAKENHI-ORGANIZER-26117001, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17K16116
  • [Journal Article] EGFR promotes glioma progression by regulating xCT and GluN2B-containing NMDA receptor signaling.2018

    • Author(s)
      Suina K, Tsuchihashi K, Yamasaki J, Kamenori S, Shintani S, Hirata Y, Okazaki S, Sampetrean O, Baba E, Akashi K, Takahashi F, Takahashi K, Saya H, Nagano O.
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 12 Pages: 3874-3882

    • DOI

      10.1111/cas.13826

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-18K15215, KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H03583, KAKENHI-PROJECT-15K09230, KAKENHI-PROJECT-16K07124, KAKENHI-PROJECT-18J14396
  • [Journal Article] T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease2018

    • Author(s)
      Tabata Yoshikuni、Imaizumi Yoichi、Sugawara Michiko、Andoh-Noda Tomoko、Banno Satoe、Chai MuhChyi、Sone Takefumi、Yamazaki Kazuto、Ito Masashi、Tsukahara Kappei、Saya Hideyuki、Hattori Nobutaka、Kohyama Jun、Okano Hideyuki
    • Journal Title

      Stem Cell Reports

      Volume: 11 Issue: 5 Pages: 1171-1184

    • DOI

      10.1016/j.stemcr.2018.09.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-17H01401
  • [Journal Article] Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells2018

    • Author(s)
      Okazaki Shogo、Shintani Subaru、Hirata Yuki、Suina Kentaro、Semba Takashi、Yamasaki Juntaro、Umene Kiyoko、Ishikawa Miyuki、Saya Hideyuki、Nagano Osamu
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 73 Pages: 33832-33843

    • DOI

      10.18632/oncotarget.26112

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H03583, KAKENHI-PROJECT-18J14396
  • [Journal Article] Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model2018

    • Author(s)
      Shibao S、Minami N、Koike N、Fukui N、Yoshida K、Saya H、Sampetrean O
    • Journal Title

      Neuro-Oncology

      Volume: 20 Issue: 3 Pages: 343-354

    • DOI

      10.1093/neuonc/nox170

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07124, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17J02715
  • [Journal Article] Inhibiting xCT Improves 5-Fluorouracil Resistance of Gastric Cancer Induced by CD44 Variant 9 Expression.2018

    • Author(s)
      Miyoshi S, Tsugawa H, Matsuzaki J, Hirata K, Mori H, Saya H, Kanai T, Suzuki H.
    • Journal Title

      Anticancer Research

      Volume: 38 Issue: 11 Pages: 6163-6170

    • DOI

      10.21873/anticanres.12969

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-16H05291, KAKENHI-PROJECT-16K08349
  • [Journal Article] Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).2017

    • Author(s)
      Shitara K, Doi T, Nagano O, Fukutani M, Hasegawa H, Nomura S, Sato A, Kuwata T, Asai K, Einaga Y, Tsuchihashi K, Suina K, Maeda Y, Saya H, Ohtsu A.
    • Journal Title

      Gastric Cancer

      Volume: 20 Issue: 6 Pages: 1004-1009

    • DOI

      10.1007/s10120-017-0720-y

    • NAID

      40021377421

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17J02923
  • [Journal Article] FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B cell acute leukemia.2017

    • Author(s)
      Ishizawa J, Sugihara E, Kuninaka S, Mogushi K, Kojima K, Benton CB, Zhao R, Chachad D, Hashimoto N, Jacamo RO, Qiu Y, Yoo SY, Okamoto S, Andreeff M, Kornblau SM, Saya H.
    • Journal Title

      Blood

      Volume: 129 Issue: 14 Pages: 1958-1968

    • DOI

      10.1182/blood-2016-07-726216

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461425, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-15K06840
  • [Journal Article] Stat3 as a potential therapeutic target for rheumatoid arthritis.2017

    • Author(s)
      Oike T, Sato Y, Kobayashi T, Miyamoto K, Nakamura S, Kaneko Y, Kobayashi S, Harato K, Saya H, Matsumoto M, Nakamura M, Niki Y, Miyamoto T.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 10965-10965

    • DOI

      10.1038/s41598-017-11233-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10917, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-15H04963, KAKENHI-PROJECT-15K10490
  • [Journal Article] cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells2017

    • Author(s)
      Miyano Kazuki、Cabral Horacio、Miura Yutaka、Matsumoto Yu、Mochida Yuki、Kinoh Hiroaki、Iwata Caname、Nagano Osamu、Saya Hideyuki、Nishiyama Nobuhiro、Kataoka Kazunori、Yamasoba Tatsuya
    • Journal Title

      J Control Release

      Volume: 261 Pages: 275-286

    • DOI

      10.1016/j.jconrel.2017.06.021

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17KT0048, KAKENHI-PROJECT-16K11226, KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-16H03179, KAKENHI-PROJECT-16H05422, KAKENHI-PROJECT-17H06641, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407, KAKENHI-PROJECT-16K15104
  • [Journal Article] Reducing Inflammatory Cytokine Production from Renal Collecting Duct Cells by Inhibiting GATA2 Ameliorates Acute Kidney Injury.2017

    • Author(s)
      Yu L, Moriguchi T, Kaneko H, Hayashi M, Hasegawa A, Nezu M, Saya H, Yamamoto M, Shimizu R.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 37 Issue: 22 Pages: 211-217

    • DOI

      10.1128/mcb.00211-17

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-15H04759, KAKENHI-PROJECT-16H05147, KAKENHI-PROJECT-17J04895
  • [Journal Article] Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.2017

    • Author(s)
      Kasai S, Furuichi Y, Ando N, Kagami K, Abe M, Nakane T, Goi K, Inukai T, Saitoh S, Ohno S, Okazaki S, Nagano O, Saya H, Sugita K.
    • Journal Title

      Cell Death and Disease

      Volume: 8 Issue: 6 Pages: e2857-e2857

    • DOI

      10.1038/cddis.2017.249

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-15K09645
  • [Journal Article] The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer.2017

    • Author(s)
      Tayama S, Motohara T, Narantuya D, Li C, Fujimoto K, Sakaguchi I, Tashiro H, Saya H, Nagano O, Katabuchi H
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 27 Pages: 44312-44325

    • DOI

      10.18632/oncotarget.17871

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11145, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-16H05473
  • [Journal Article] Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer.2017

    • Author(s)
      Otsubo K, Nosaki K, Imamura CK, Ogata H, Fujita A, Sakata S, Hirai F, Toyokawa G, Iwama E, Harada T, Seto T, Takenoyama M, Ozeki T, Mushiroda T, Inada M, Kishimoto J, Tsuchihashi K, Suina K, Nagano O, Saya H, Nakanishi Y, Okamoto I.
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 9 Pages: 1843-1849

    • DOI

      10.1111/cas.13309

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01401
  • [Journal Article] :Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response.2017

    • Author(s)
      Shimizu T, Kamel WA, Yamaguchi-Iwai S, Fukuchi Y, Muto A, Saya H.
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 9 Pages: 1793-1802

    • DOI

      10.1111/cas.13304

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-16J40108, KAKENHI-PROJECT-15K06845
  • [Journal Article] Organotypic brain explant culture as a drug evaluation system for malignant brain tumors2017

    • Author(s)
      Minami N、Maeda Y、Shibao S、Arima Y、Ohka F、Kondo Y、Maruyama K、Kusuhara M、Sasayama T、Kohmura E、Saya H、Sampetrean O
    • Journal Title

      Cancer Medicine

      Volume: 6 Issue: 11 Pages: 2635-2645

    • DOI

      10.1002/cam4.1174

    • NAID

      120006373813

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07124, KAKENHI-PROJECT-17K10863, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H03582, KAKENHI-PROJECT-17J02715, KAKENHI-PROJECT-15K10332
  • [Journal Article] Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells.2017

    • Author(s)
      Ishimoto T, Miyake K, Nandi T, Yashiro M, Onishi N, Huang KK, Joyce LN, Kalpana R, Tay ST, Suzuki Y, Cho BC, Kuroda D, Arima K, Izumi D, Iwatsuki M, Baba Y, Oki E, Watanabe M, Saya H, Hirakawa K, Baba H, Tan P.
    • Journal Title

      Gastroenterology

      Volume: in press Issue: 1 Pages: 191-204

    • DOI

      10.1053/j.gastro.2017.03.046

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06257, KAKENHI-PROJECT-26293290, KAKENHI-PROJECT-16K15595, KAKENHI-PROJECT-16K07125, KAKENHI-PROJECT-17K10596, KAKENHI-PROJECT-17K10639, KAKENHI-PROJECT-26293307, KAKENHI-PROJECT-17H01401
  • [Journal Article] ALKR1275Q perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.2016

    • Author(s)
      Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda ZI, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H.
    • Journal Title

      Oncogene.

      Volume: 無 Issue: 34 Pages: 4447-4458

    • DOI

      10.1038/onc.2015.519

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-25460416, KAKENHI-PROJECT-15K14384, KAKENHI-PROJECT-26670493, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-26293242, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-16K08691
  • [Journal Article] The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)2016

    • Author(s)
      Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H and Nagano O
    • Journal Title

      Cancer Res

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Journal Article] MIF maintains the tumorigenic capacity of brain tumor-initiating cells by directly inhibiting p532016

    • Author(s)
      Fukaya R, Ohta S, Yaguchi T, Matsuzaki Y, Sugihara E, Okano H, Saya H, Kawakami Y, Kawase T, Yoshida K and Toda M
    • Journal Title

      Cancer Res

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Journal Article] Periostin Is a Key Niche Component for Wound Metastasis of Melanoma.2015

    • Author(s)
      Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0129704-e0129704

    • DOI

      10.1371/journal.pone.0129704

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06840, KAKENHI-PROJECT-15K09553, KAKENHI-PROJECT-15K15372, KAKENHI-PROJECT-15K19704, KAKENHI-PROJECT-15K14384, KAKENHI-PROJECT-25293224
  • [Journal Article] Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression2015

    • Author(s)
      Kozono D, Li J, Nitta M, Sampetrean O, Gonda D, Kushwaha DS, Merzon D, Ramakrishnan V, Zhu S, Zhu K, Matsui H, Harismendy O, Hua W, Mao Y, Kwon CH, Saya H, Nakano I, Pizzo DP, VandenBerg SR and Chen CC
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 112 Issue: 30 Pages: 112-130

    • DOI

      10.1073/pnas.1501967112

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25253085, KAKENHI-PROJECT-26861168
  • [Journal Article] Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.2015

    • Author(s)
      Adachi T, Kobayashi T, Sugihara E, Yamada T, Ikuta K, Pittaluga S, Saya H, Amagai M, Nagao K.
    • Journal Title

      Nature Med.

      Volume: 21 Issue: 11 Pages: 1272-1279

    • DOI

      10.1038/nm.3962

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06840, KAKENHI-PUBLICLY-15H01153, KAKENHI-PROJECT-26253065, KAKENHI-PROJECT-25460589, KAKENHI-PROJECT-15K14384
  • [Journal Article] Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation.2014

    • Author(s)
      Yoshida GJ and Saya H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 443 Issue: 2 Pages: 622-627

    • DOI

      10.1016/j.bbrc.2013.12.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Journal Article] Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model2014

    • Author(s)
      Saga I, Shibao S, Okubo J, Osuka S, Kobayashi Y, Yamada S, Fujita S, Urakami K, Kusuhara M, Yoshida K, Saya H, Sampetrean O
    • Journal Title

      Neuro Oncol.

      Volume: 16 Issue: 8 Pages: 1048-1056

    • DOI

      10.1093/neuonc/nou096

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13J06657, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-25253085, KAKENHI-PROJECT-26830082, KAKENHI-PROJECT-26861168
  • [Journal Article] A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.2014

    • Author(s)
      Inagawa Y, Yamada K, Yugawa T, Ohno SI, Hiraoka N, Esaki M, Shibata T, Aoki K, Saya H and Kiyono T
    • Journal Title

      Carcinogenesis

      Volume: 35 Issue: 8 Pages: 1840-1846

    • DOI

      10.1093/carcin/bgu112

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-26460406
  • [Journal Article] がん幹細胞マーカーCD44による細胞内グルタチオン制御2014

    • Author(s)
      玉田真由美 佐谷秀行
    • Journal Title

      細胞

      Volume: Vol.46 No.3

    • Data Source
      KAKENHI-PROJECT-25870717
  • [Journal Article] Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry.2014

    • Author(s)
      Ohmura M, Hishiki T, Yamamoto T, Nakanishi T, Kubo A, Tsuchihashi K, Tamada M, Toue S, Kabe Y, Saya H and Suematsu M
    • Journal Title

      Nitric Oxide

      Volume: pii: S1089-8603 Pages: 495-499

    • DOI

      10.1016/j.niox.2014.11.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-25870717, KAKENHI-PUBLICLY-26117726, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-25513008
  • [Journal Article] Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas.2014

    • Author(s)
      Mikami S, Mizuno R, Kosaka T, Saya H, Oya M and Okada Y
    • Journal Title

      Int J Cancer

      Volume: 136 Issue: 7 Pages: 1504-1514

    • DOI

      10.1002/ijc.29137

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390374, KAKENHI-PROJECT-25460422
  • [Journal Article] Expression of CD24 is associated with HER2 expression and supports HER2-Akt signaling in HER2-positive breast cancer cells.2014

    • Author(s)
      Hosonaga M, Arima Y, Sugihara E, Kohno N and Saya H
    • Journal Title

      Cancer Sci

      Volume: 105 Issue: 7 Pages: 779-787

    • DOI

      10.1111/cas.12427

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-25461995, KAKENHI-PROJECT-25860245
  • [Journal Article] Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation.2014

    • Author(s)
      Nobusue H
    • Journal Title

      Nat Commun

      Volume: 5 Issue: 1 Pages: 3368-3368

    • DOI

      10.1038/ncomms4368

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130002, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245
  • [Journal Article] Functional analysis of a novel glioma antigen, EFTUD1.2014

    • Author(s)
      Saito K, Iizuka Y, Ohta S, Takahashi S, Nakamura K, Saya H, Yoshida K, Kawakami Y and Toda M
    • Journal Title

      Neuro-Oncol

      Volume: 16 Pages: 1618-1629

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Journal Article] Functional analysis of a novel glioma antigen, EFTUD12014

    • Author(s)
      Saito K, Iizuka Y, Ohta S, Takahashi S, Nakamura K, Saya H, Yoshida K, Kawakami Y, Toda M
    • Journal Title

      Neuro Oncol

      Volume: 16 Issue: 12 Pages: 1618-1629

    • DOI

      10.1093/neuonc/nou132

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592172, KAKENHI-PROJECT-24659657, KAKENHI-PROJECT-25253085, KAKENHI-PROJECT-25293313
  • [Journal Article] TNF-a/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells2014

    • Author(s)
      Oshima H, Ishikawa T, Yoshida GJ, et al.
    • Journal Title

      Oncogene

      Volume: 33 Issue: 29 Pages: 3820-3829

    • DOI

      10.1038/onc.2013.356

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22114005, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24300325, KAKENHI-PROJECT-24501314, KAKENHI-PROJECT-25430107, KAKENHI-PROJECT-25670572
  • [Journal Article] TSPAN2 Is Involved in Cell Invasion and Motility during Lung Cancer Progression.2014

    • Author(s)
      Otsubo C, Otomo R, Miyazaki M, Matsushima-Hibiya Y, Kohno T, Iwakawa R, Takeshita F, Okayama H, Ichikawa H, Saya H, Kiyono T, Ochiya T, Tashiro F, Nakagama H, Yokota J and Enari M
    • Journal Title

      Cell Rep

      Volume: 7 Issue: 2 Pages: 527-538

    • DOI

      10.1016/j.celrep.2014.03.027

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Journal Article] IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress2014

    • Author(s)
      Shimizu T, Sugihara E, Yamaguchi-Iwai S, Tamaki S, Koyama Y, Kamel W, Ueki A, Ishikawa T, Chiyoda T, Osuka S, Onishi N, Ikeda H, Kamei J, Matsuo K, Fukuchi Y, Nagai T, Toguchida J, Toyama Y, Muto A, Saya H
    • Journal Title

      Cancer Res

      Volume: 74 Issue: 22 Pages: 6531-6541

    • DOI

      10.1158/0008-5472.can-14-0914

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J06657, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245, KAKENHI-PROJECT-26830082
  • [Journal Article] A stem cell medium containing neural stimulating factor induces a pancreatic cancer stem-like cell-enriched population.2014

    • Author(s)
      Watanabe Y, Yoshimura K, Yoshikawa K, Tsunedomi R, Shindo Y, Matsukuma S, Maeda N, Kanekiyo S, Suzuki N, Kuramasu A, Sonoda K, Tamada K, Kobayashi S, Saya H, Hazama S and Oka M
    • Journal Title

      Int J Oncol

      Volume: 45 Issue: 5 Pages: 1857-1866

    • DOI

      10.3892/ijo.2014.2603

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390317, KAKENHI-PROJECT-25290057, KAKENHI-PROJECT-25861192, KAKENHI-PROJECT-26293373, KAKENHI-PROJECT-26670755
  • [Journal Article] CD44s signals the acquisition of the mesenchymal phenotype required for anchorage-independent cell survival in hepatocellular carcinoma.2014

    • Author(s)
      Okabe H, Ishimoto T, Mima K, Nakagawa S, Hayashi H, Kuroki H, Imai K, Nitta H, Saito S, Hashimoto D, Chikamoto A, Ishiko T, Watanabe M, Nagano O, Beppu T, Saya H and Baba H
    • Journal Title

      Br J Cancer

      Volume: 印刷中 Issue: 4 Pages: 958-66

    • DOI

      10.1038/bjc.2013.759

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-23791549, KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24592008
  • [Journal Article] CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.2013

    • Author(s)
      Hirata K, Suzuki H, Imaeda H, Matsuzaki J, Tsugawa H, Nagano O, Asakura K, Saya H, Hibi T
    • Journal Title

      Br J Cancer

      Volume: 109 Issue: 2 Pages: 379-386

    • DOI

      10.1038/bjc.2013.314

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24659103, KAKENHI-PROJECT-25293178, KAKENHI-PROJECT-25460173
  • [Journal Article] TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state.2013

    • Author(s)
      Mori T
    • Journal Title

      Oncogene

      Volume: Epub ahead of print Issue: 33 Pages: 4236-4241

    • DOI

      10.1038/onc.2013.545

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390359, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24592244, KAKENHI-PROJECT-25861341
  • [Journal Article] Acquired expression of NFATc1 downregulates E-cadherin and promotes cancer cell invasion.2013

    • Author(s)
      Oikawa T
    • Journal Title

      Cancer Res

      Volume: 73 Issue: 16 Pages: 5100-5109

    • DOI

      10.1158/0008-5472.can-13-0274

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001, KAKENHI-PROJECT-23659162, KAKENHI-PROJECT-23689020, KAKENHI-PROJECT-25253085, KAKENHI-PROJECT-25830088
  • [Journal Article] The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells2013

    • Author(s)
      Naoe H, Chiyoda T, Ishizawa J, Masuda K, Saya H, Kuninaka S
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 430(2) Pages: 757-62

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590980
  • [Journal Article] In vivo pH monitoring using boron doped diamond microelectrode and silver needles: Application to stomach disorder diagnosis.2013

    • Author(s)
      Fierro S, Seishima R, Nagano O, Saya H and Einaga Y
    • Journal Title

      Sci Rep

      Volume: 3 Issue: 1 Pages: 3257-3257

    • DOI

      10.1038/srep03257

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24590389
  • [Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma2013

    • Author(s)
      Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
    • Journal Title

      Cancer Res

      Volume: 73(6) Issue: 6 Pages: 1855-1866

    • DOI

      10.1158/0008-5472.can-12-3609-t

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592100, KAKENHI-PROJECT-23659941, KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-24591912, KAKENHI-PROJECT-24592965, KAKENHI-PROJECT-24791713, KAKENHI-PROJECT-24792194, KAKENHI-PROJECT-25293344, KAKENHI-PROJECT-25870730, KAKENHI-PLANNED-22130007
  • [Journal Article] IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells.2013

    • Author(s)
      Osuka S, Sampetrean O, Saya H et al.
    • Journal Title

      Stem Cells

      Volume: 31 Pages: 627-640

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] Characteristics of glioma stem cells2013

    • Author(s)
      Sampetrean O and Saya H
    • Journal Title

      Brain Tumor Pathol2013

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] Establishment of HRASG12V Transgenic Medaka as a Stable Tumor Model for In Vivo Screening of Anticancer Drugs.2013

    • Author(s)
      Matsuzaki Y, Hosokai H, Mizuguchi Y, Fukamachi S, Shimizu A, Saya H
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 1 Pages: e54424-e54424

    • DOI

      10.1371/journal.pone.0054424

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591633, KAKENHI-PLANNED-22130007
  • [Journal Article] Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia2013

    • Author(s)
      Wada T, Ishimoto T, Seishima R, Tsuchihashi K, Yoshikawa M, et al
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 10 Pages: 1323-9

    • DOI

      10.1111/cas.12236

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J06428, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24591912
  • [Journal Article] Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor2012

    • Author(s)
      Sugihara E, Saya H, et al
    • Journal Title

      Oncogene

      Volume: (印刷中) Issue: 23 Pages: 2849-2861

    • DOI

      10.1038/onc.2011.462

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-22700865, KAKENHI-PROJECT-23590350, KAKENHI-PROJECT-23616003, KAKENHI-PROJECT-23790376
  • [Journal Article] Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer2012

    • Author(s)
      Arima Y, Saya H, et al
    • Journal Title

      Journal of Biological Chemistry

      Volume: 287 Issue: 11 Pages: 7896

    • DOI

      10.1074/jbc.m111.313759

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650601, KAKENHI-PROJECT-24590360
  • [Journal Article] Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer2012

    • Author(s)
      Arima Y, Saya H, et al
    • Journal Title

      InternationalJournal of Cancer

      Volume: 130 Issue: 11 Pages: 2568-2579

    • DOI

      10.1002/ijc.26271

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650601, KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-23791496
  • [Journal Article] Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer2012

    • Author(s)
      Yoshimi Arima, Hidemi Hayashi, Mikako Sasaki, Mari Hosonaga, Takaaki M. Goto, Tatsuyuki Chiyoda, Shinji Kuninaka, Tatsuhiro Shibata, Hirokazu Ohata, Hitoshi Nakagama, Yoichi Taya, Hideyuki Saya
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 7896-7906

    • Data Source
      KAKENHI-PROJECT-23650601
  • [Journal Article] Induction of ZEB by inactivation of RB is a key determinant of the mesenchymal phenotype of breast cancer2012

    • Author(s)
      Arima Y, Hayashi H, Sasaki M, Hosonaga M, Goto TM, Chiyoda T, Kuninaka S, Shibata T, Ohata H, Nakagama H, Taya Y and Saya H
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 7896-7906

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Journal Article] Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer2012

    • Author(s)
      Arima Y, Hayashi N, Hayashi H, Sasaki M, Kai K, Sugihara E, Abe E, Yoshida A, Mikami S, Nakamura S and Saya H
    • Journal Title

      Int J Cancer

      Volume: 130 Pages: 2568-2579

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Journal Article] LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression2012

    • Author(s)
      Chiyoda T, Sugiyama N, Shimizu T, Naoe H, Kobayashi Y, Ishizawa J, Arima Y, Tsuda H, Ito M, Kaibuchi K, Aoki D, Ishihama Y, Saya H, and Kuninaka S.
    • Journal Title

      Journal of Cell Biology

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590980
  • [Journal Article] Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells2012

    • Author(s)
      Mayumi Tamada, et al
    • Journal Title

      Cancer Research

      Volume: 72 Issue: 6 Pages: 1438-1448

    • DOI

      10.1158/0008-5472.can-11-3024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J55543, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-22700865, KAKENHI-PROJECT-22710222, KAKENHI-PROJECT-23790376
  • [Journal Article] RNA-Binding Protein Musashi1 Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI(3) Kinase/Akt Signaling Pathways2012

    • Author(s)
      Muto J, Saya H et al.
    • Journal Title

      PLos One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] Fibroblast Growth Factor-2 Is an Important Factor that Maintains Cellular Immaturity and Contributes to Aggressiveness of Osteosarcoma2012

    • Author(s)
      Shimizu T., et al
    • Journal Title

      Mol Cancer Res

      Volume: 10(3) Issue: 3 Pages: 454-468

    • DOI

      10.1158/1541-7786.mcr-11-0347

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06969, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-22241052, KAKENHI-PROJECT-22700865, KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-23791293, KAKENHI-PROJECT-24590360
  • [Journal Article] Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells2012

    • Author(s)
      Tamada M, Nagano O, Tateyama S, Ohmura M, Yae T, Ishimoto T, Sugihara E, Onishi N, Yamamoto T, Yanagawa H, Suematsu M and Saya H
    • Journal Title

      Cancer Res

      Volume: 72 Pages: 1438-1448

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Journal Article] RNA-Binding Protein Musashil Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI(3) Kinase/Akt Signaling Pathways2012

    • Author(s)
      Muto J, Saya H, et al
    • Journal Title

      PLos One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] Loss of p16 expression is associated with the stem cell characteristics of sureface markers and therapeutic resistance in estrogen receptor-negative breast cancer2011

    • Author(s)
      Arima Y, Naoki Hayashi, Hidemi Hayashi, Mikako Sasaki, Kazuharu Kai, Eiji Sugihara, Eriko Abe, Atsushi Yoshida, Shuji Mikami, Seigo Nakamura, Hideyuki Saya
    • Journal Title

      Int J Cancer

      Volume: 130 Pages: 2568-2579

    • Data Source
      KAKENHI-PROJECT-23650601
  • [Journal Article] Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells2011

    • Author(s)
      Tabuse M, Ohta S, Ohashi Y, Fukaya R, Misawa A, Yoshida K, Kawase T, Saya H, Thirant C, Chneiweiss H, Matsuzaki Y, Okano H, Kawakami Y, Toda M
    • Journal Title

      Mol Cancer

      Volume: 10 Issue: 1 Pages: 60-60

    • DOI

      10.1186/1476-4598-10-60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390062, KAKENHI-PROJECT-22249055, KAKENHI-PROJECT-22390283, KAKENHI-PROJECT-22791356, KAKENHI-PROJECT-23240128
  • [Journal Article] Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells.2011

    • Author(s)
      Sampetrean O, Saya H et al
    • Journal Title

      Neoplasia

      Volume: 13 Pages: 784-791

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] Establishment of a Choriocarcinoma Model from Immortalized Normal Extravillous Trophoblast Cells Transduced with HRASV122011

    • Author(s)
      Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K, Kuninaka S, Aoki D, Saya H.
    • Journal Title

      The American Journal of Pathology

      Volume: 179 Pages: 1471-1482

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590980
  • [Journal Article] CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc- and thereby promotes tumor growth.2011

    • Author(s)
      Ishimoto T, Saya H et al
    • Journal Title

      Cancer Cell

      Volume: 19 Pages: 387-400

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress2011

    • Author(s)
      Ishizawa J, Kuninaka S, Sugihara E, Naoe H, Kobayashi Y, Chiyoda T, Ueki A, Araki K, Yamamura KI, Matsuzaki Y, Nakajima H, Ikeda Y, Okamoto S, Saya H.
    • Journal Title

      Cancer Science

      Volume: 22 Pages: 1-8

    • NAID

      10029293305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590980
  • [Journal Article] Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells2011

    • Author(s)
      Sampetrean O, Saga I, Nakanishi M, Sugihara E, Fukaya R, Onishi N, Osuka A, Akahata M, Kai K, Sugimoto H, Hirao A, and Saya H
    • Journal Title

      Neoplasia

      Volume: 13 Pages: 784-791

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress.2011

    • Author(s)
      Ishizawa J, Saya H, et al.
    • Journal Title

      Cancer Sci

    • NAID

      10029293305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] NKX2.2 suppresses self renewal of glioma-initiating cells.2011

    • Author(s)
      Muraguchi T, Saya H, et al.
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 1135-1145

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Journal Article] Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells2011

    • Author(s)
      Sampetrean O, Saya H, et al
    • Journal Title

      Neoplasia

      Volume: 13 Pages: 784-791

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc(-) and Thereby Promotes Tumor Growth2011

    • Author(s)
      Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T, Shimizu T, Ishikawa T, Kai K, Takahashi E, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H, Saya H
    • Journal Title

      Cancer Cell

      Volume: 19(3) Pages: 387-400

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] NKX2.2 suppresses self renewal of glioma-initiating cells.2011

    • Author(s)
      Muraguchi T, Saya H, et al.
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 1135-1145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress.2011

    • Author(s)
      Ishizawa J, Saya H, et al.
    • Journal Title

      Cancer Sci

    • NAID

      10029293305

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Journal Article] CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc- and thereby promotes tumor growth.2011

    • Author(s)
      Ishimoto T, Saya H, et al.
    • Journal Title

      Cancer Cell

      Volume: 19 Pages: 387-400

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress2011

    • Author(s)
      Ishizawa J, Saya H et al.
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 967-974

    • NAID

      10029293305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] NKX2.2 suppresses self-renewal of glioma-initiating cells2011

    • Author(s)
      Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, Hirao A
    • Journal Title

      Cancer Res

      Volume: 71(3) Pages: 1135-45

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation2010

    • Author(s)
      Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H, Kuninaka S
    • Journal Title

      Mol Cell Biol

      Volume: 30(16) Pages: 3994-4005

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] Experimental therapies : Investigator-initiated cancer trials with INDs for approval in Japan2010

    • Author(s)
      Imamura CK, Takebe N, Nakamura S, Saya H, Ueno NT
    • Journal Title

      Nat Rev Clin Oncol

      Volume: 7(3) Pages: 127-8

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells.2010

    • Author(s)
      Tajima K, Saya H, et al.
    • Journal Title

      Oncogene

      Volume: 29 Pages: 1941-1951

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650229
  • [Journal Article] Identification of CD44 as a cell surface marker for Muller glia precursor cells.2010

    • Author(s)
      Shinoe T, Saya H et al
    • Journal Title

      J Neurochem

      Volume: 115 Pages: 1633-1642

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.2010

    • Author(s)
      Shimizu T, Saya H et al
    • Journal Title

      Oncogene

      Volume: 29 Pages: 5687-5699

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] Mad2 inhibits the mitotic kinesin MKlp22010

    • Author(s)
      Lee SH, McCormick F, Saya H
    • Journal Title

      J Cell Biol

      Volume: 191(6) Pages: 1069-77

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] Mad2 targets the mitotic kinesin MKlp2 and inhibits its kinesin function required for cytokinesis.2010

    • Author(s)
      Lee SH, Saya H et al
    • Journal Title

      J Cell Biol

      Volume: 191 Pages: 1069-1077

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] The APC/C activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.2010

    • Author(s)
      Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H, Kuninaka S
    • Journal Title

      Mol Cell Biol (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway2010

    • Author(s)
      Techasen A, Loilome W, Namwat N, Takahashi E, Sugihara E, Puapairoj A, Miwa M, Saya H, Yongvanit P
    • Journal Title

      Cancer Sci

      Volume: 101(3) Pages: 658-65

    • NAID

      10026589391

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis2010

    • Author(s)
      Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H, Nagano O
    • Journal Title

      Cancer Sci

      Volume: 101(3) Pages: 673-8

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD 44-moesin interaction2010

    • Author(s)
      Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, Nakamura S, Niwa S, Ikeda S, Koga H, Tanihara H, Saya H
    • Journal Title

      J Biol Chem

      Volume: 285(6) Pages: 4060-73

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] The APC/C activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.2010

    • Author(s)
      Naoe H, Saya H, et al.
    • Journal Title

      Mol Cell Biol

      Volume: 30 Pages: 3994-4005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650229
  • [Journal Article] Mad2 targets the mitotic kinesin MKlp2 and inhibits its kinesin function required for cytokinesis.2010

    • Author(s)
      Lee SH, Saya H, et al.
    • Journal Title

      J Cell Biol

      Volume: 191 Pages: 1069-1077

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis2010

    • Author(s)
      Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda T, Saya H
    • Journal Title

      Oncogene

      Volume: 29(42) Pages: 5687-99

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] Identification of CD44 as a cell surface marker for Muller glia precursor cells2010

    • Author(s)
      Shinoe T, Kuribayashi H, Saya H, Seiki M, Aburatani H, Watanabe S
    • Journal Title

      J Neurochem

      Volume: 115(6) Pages: 1633-42

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.2010

    • Author(s)
      Shimizu T, Saya H, et al.
    • Journal Title

      Oncogene

      Volume: 29 Pages: 5687-5699

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Journal Article] Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1 (NF1).2010

    • Author(s)
      Arima Y, Saya H, et al.
    • Journal Title

      Exp Dermatol

      Volume: 19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650229
  • [Journal Article] NKX2.2 suppresses self-renewal of glioma-initiating cells.2010

    • Author(s)
      Muraguchi T, Saya H et al.
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 1135-1145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] Breast cancer stem cells2010

    • Author(s)
      Kai K, Arima Y, Kamiya T, Saya H
    • Journal Title

      Breast Cancer

      Volume: 17(2) Pages: 80-5

    • NAID

      10027255296

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells2010

    • Author(s)
      Tajima K, Ohashi R, Sekido Y, Hida T, Nara T, Hashimoto M, Iwakami S, Minakata K, Yae T, Takahashi F, Saya H, Takahashi K
    • Journal Title

      Oncogene

      Volume: 29(13) Pages: 1941-51

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] PRKAR1A is over-expressed and represents a possible therapeutic target in human cholangiocarcinoma.2010

    • Author(s)
      Loilome W, Saya H, et al.
    • Journal Title

      Int J Cancer

      Volume: 129 Pages: 34-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650229
  • [Journal Article] PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties2010

    • Author(s)
      Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N
    • Journal Title

      Cancer Res

      Volume: 70(3) Pages: 1215-24

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 12010

    • Author(s)
      Arima Y, Hayashi H, Kamata K, Goto TM, Sasaki M, Kuramochi A, Saya H
    • Journal Title

      Exp Dermatol

      Volume: 19(8)

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] Proteome profiling reveals gender differences in the composition of human serum2010

    • Author(s)
      Miike K, Aoki M, Yamashita R, Takegawa Y, Saya H, Miike T, Yamamura K
    • Journal Title

      Proteomics

      Volume: 10(14) Pages: 2678-91

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Journal Article] Identification of CD44 as a cell surface marker for Muller glia precursor cells.2010

    • Author(s)
      Shinoe T, Saya H, et al.
    • Journal Title

      J Neurochem

      Volume: 115 Pages: 1633-1642

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Journal Article] Mad2 targets the mitotic kinesin Mk1-p2 and inhibits its kinesin function required for cytokinesis.2010

    • Author(s)
      Lee SH, Saya H, et al.
    • Journal Title

      J Cell Biol

      Volume: 191 Pages: 1069-1077

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Journal Article] MARCKS phosphorylation promotes cholangiocarcinoma cell migration and metastasis via PKC-dependent pathway.2010

    • Author(s)
      Techasen A, Saya H, et al.
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 655-665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650229
  • [Journal Article] An essential role of the aPKC-Aurora A-NDEL1 pathway on neurite elongation by modulation of microtubule dynamics.2009

    • Author(s)
      Mori D, Yamada M, Mimori-Kiyosue Y, Shirai Y, Suzuki A, Ohno S, Saya H, Wynshaw-Boris A, Hirotsune S
    • Journal Title

      Nat Cell Biol 11

      Pages: 1057-1068

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.2009

    • Author(s)
      Nakai R, Iida S, Takahashi T, Tsujita T, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H, Akinaga S, Murakata C, Honda S, Nitta M, Saya H, Yamashita Y
    • Journal Title

      Cancer Res 69

      Pages: 3901-3909

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] Reversible whole-organism cell cycle arrest in a living vertebrate2009

    • Author(s)
      Sampetrean O, Iida S, Makino S, Matsuzaki Y, Ohno K and Saya H
    • Journal Title

      Cell Cycle 8

      Pages: 620-627

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] 抗癌剤効果の分子機構2009

    • Author(s)
      佐谷秀行
    • Journal Title

      癌と化学療法(癌と化学療法社) 36

      Pages: 1-5

    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis2009

    • Author(s)
      Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H and Suda T
    • Journal Title

      J Exp Med 206

      Pages: 1089-1102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] Reversible whole-organism cell cycle arrest in a living vertebrate.2009

    • Author(s)
      Sampetrean O, Iida S, Makino S, Matsuzaki Y, Ohno K, Saya H
    • Journal Title

      Cell Cycle 8

      Pages: 620-627

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells2009

    • Author(s)
      Nakai R, Iida S, Takahashi T, Tsujita T, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H, Akinaga S, Murakata C, Honda S, Nitta M, Saya H and Yamashita Y
    • Journal Title

      Cancer Res 69

      Pages: 3901-3909

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress2009

    • Author(s)
      Inumaru J, Nagano O, Takahashi E, Ishimoto T, Nakamura S, Suzuki Y, NiwaSI, Umezawa K, Tanihara H and Saya H
    • Journal Title

      Genes Cells(Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] NF1 tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein,collapsin response mediator protein-22008

    • Author(s)
      Patrakitkomjorn S, Kobayashi D, Morikawa T, Wilson MM, Tsubota N, Irie A, Ozawa T, Aoki M, Arimura N, Kaibuchi K, Saya H and Araki N
    • Journal Title

      J Biol Chem 283

      Pages: 9399-9413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] p53 regulates TLR3 expression and function in human epithelial cell lines2008

    • Author(s)
      Taura M, Eguma A, Suico MA, Shuto T, Koga T, Komatsu K, Komune T, Sato T, Saya H, Li JD and Kai H
    • Journal Title

      Mol Cell Biol 28

      Pages: 6557-6567

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] Aurora-Aの発がんにおける役割2008

    • Author(s)
      張東威、佐谷秀行
    • Journal Title

      実験医学増刊「シグナル伝達研究2008-'09」(羊土社) 26

    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] Aurora-A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice2008

    • Author(s)
      Zhang D, Shimizu T, Araki N, Hirota T, Yoshie M, Ogawa K, Nakagata N, Takeya M and Saya H
    • Journal Title

      Oncogene 27

      Pages: 4305-4314

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] Aurora-A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice2008

    • Author(s)
      D. Zhang, T. Shimizu, N. Araki, T. Hirota, M. Yoshie, K. Ogawa, N. Nakagata, M. Takeya, H. Saya
    • Journal Title

      Oncogene 27

      Pages: 4305-4314

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-32008

    • Author(s)
      Fumoto K, Lee PC, Saya H and Kikuchi A
    • Journal Title

      Oncogene 27

      Pages: 4478-4487

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] Activated macrophages promote Wnt signaling through tumor necrosis factor- in gastric tumor cells2008

    • Author(s)
      Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S, Hirao A, Saya H, Taketo MM and Oshima M
    • Journal Title

      EMBO J 27

      Pages: 1671-1681

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] Neurofibromatosis Type I tumor suppressor, neurofibromin, regulates the neurite outgrowth of PC12 cells via its associating protein, CRMP-22008

    • Author(s)
      Patrakitkomjorn S, Kobayashi D, Morikawa T, Wilson MM, Tsubota N, Irie A, Ozawa T, Aoki M, Arimura N, Kaibuchi K, Saya H, Araki N
    • Journal Title

      J. Biol. Chem 283(14)

      Pages: 9399-413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390382
  • [Journal Article] Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristics of the epithelial to mesenchymal transition2008

    • Author(s)
      Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H and Taya Y
    • Journal Title

      Cancer Res 68

      Pages: 5104-5112

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint2008

    • Author(s)
      Kim S, Park SY, Yong H, Famulski JK, Chae S, Lee JH, Kang CM, Saya H, Chan GK, and Cho H
    • Journal Title

      Oncogene 27

      Pages: 3457-3464

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] Aurora-A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.2008

    • Author(s)
      Zhang D, Shimizu T, Araki N, Hirota T, Yoshie M, Ogawa K, Nakagata N, Takeya M, Saya H
    • Journal Title

      Oncogene 27

      Pages: 4305-4314

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] Auroraキナーゼの機能と発がんにおける役割2007

    • Author(s)
      佐谷秀行
    • Journal Title

      日本生化学会 79

      Pages: 131-139

    • NAID

      10018733578

    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] Auroraキナーゼの機能と発がんにおける役割。2007

    • Author(s)
      佐谷秀行
    • Journal Title

      生化学 79

      Pages: 131-139

    • NAID

      10018733578

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209049
  • [Journal Article] Wynshaw-Boris A and Hirotsune S. NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation,separation, and TACC3 recruitment2007

    • Author(s)
      Mori D, Yano Y, Toyo-oka K, Yoshida N, Yamada M, Muramatsu M, Zhang D, Saya H, Toyoshima YY, Kinoshita K
    • Journal Title

      Mol Cell Biol 27

      Pages: 352-367

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] Visualizing the dynamics of p21^<Waf1/Cip1> cyclin-dependent kinase inhibitor expression in living animals2007

    • Author(s)
      Ohtani N, Imamura Y, Yamakoshi K, Hirota F, Nakayama R, Kubo Y, Ishimaru N, Takahashi A, Hirao A, Shimizu T, Mann DJ, Saya H, Hayashi Y, Arase S, Matsumoto M, Kazuki N and Hara E
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 15034-15039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] Auroraキナーゼの機能と発がんにおける役割。2007

    • Author(s)
      佐谷秀行
    • Journal Title

      生化学 79

      Pages: 131-139

    • NAID

      10018733578

    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.2007

    • Author(s)
      Kuninaka S, Iida S, Hara T, Nomura M, Naoe H, Morisaki T, Nitta M, Arima Y, Mimori T, Yonehara S, Saya H
    • Journal Title

      Oncogene 26

      Pages: 2395-2406

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] auroraキナーゼの機能と発がんにおける役割。2007

    • Author(s)
      佐谷秀行
    • Journal Title

      生化学 79

      Pages: 131-139

    • NAID

      10018733578

    • Data Source
      KAKENHI-PROJECT-17209049
  • [Journal Article] Aurora kinase : Functions and roles in tumorigenesis2007

    • Author(s)
      Saya H
    • Journal Title

      J. Biochemistry 79

      Pages: 131-139

    • NAID

      10018733578

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209049
  • [Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation2007

    • Author(s)
      Kuninaka S, Iida S, Hara T, Nomura M, Naoe H, Morisaki T, Nitta M, Arima Y, Mimori T, Yonehara S and Saya H
    • Journal Title

      Oncogene 26

      Pages: 2395-2406

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Journal Article] Auroraキナーゼの機能と発がんにおける役割。2007

    • Author(s)
      佐谷秀行
    • Journal Title

      生化学 79

      Pages: 131-139

    • NAID

      10018733578

    • Data Source
      KAKENHI-PROJECT-18659089
  • [Journal Article] Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.2006

    • Author(s)
      Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, Nakayama KI, Ide T, Saya H, Hara E
    • Journal Title

      Nat Cell Biol 8

      Pages: 1291-1297

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] Organ size control mediated by WARTS kinase play a role in tumor suppression2006

    • Author(s)
      Shinji, Kuninaka, Hideyuki, Saya
    • Journal Title

      Experimental Medicine 24-11

      Pages: 1610-1615

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Journal Article] WARTSキナーゼを介した器官サイズ制御と発癌抑制の接点2006

    • Author(s)
      國仲 慎治、佐谷 秀行
    • Journal Title

      実験医学 24

      Pages: 1610-1615

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Journal Article] Aurora A - A guardian of poles.2005

    • Author(s)
      Marumoto T, Zhang D, Saya H
    • Journal Title

      Nat Rev Cancer 5

      Pages: 42-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] 細胞分裂とその制御2005

    • Author(s)
      佐谷秀行
    • Journal Title

      分子細胞治療(特集監修, 先端医学社) 4

      Pages: 465-466

    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.2005

    • Author(s)
      Ozawa T, Araki N, Yunoue S, Tokuo H, Feng L, Patrakitkomjom S, Hara T, Ichikawa Y, Matsumoto K, Fujii K, Saya H
    • Journal Title

      J Biol Chem 280

      Pages: 39524-39533

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390413
  • [Journal Article] Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria.2005

    • Author(s)
      Arima Y, Nitta M, Kuninaka S, Zhang D, Fujiwara T, Taya Y, Nakao M, Saya H
    • Journal Title

      J Biol Chem 280

      Pages: 19166-19176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] Observation of the Intracellular Behavior of Recombinant Yersinia pseudotuberculosis Invasin Protein.2005

    • Author(s)
      Koga H, Izawa I, Araki N, Saya H, Mimori T.
    • Journal Title

      Microbiol Immunol. 49(4)

      Pages: 297-302

    • NAID

      10015527670

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390413
  • [Journal Article] Aurora A - A guardian of poles2005

    • Author(s)
      T. Marumoto, D. Zhang, H. Saya
    • Journal Title

      Nat. Rev. Cancer 5

      Pages: 42-50

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] The tumor suppressor WARTS activates the Omi/HtrA2-dependent pathway of cell death.2005

    • Author(s)
      Kuninaka S, Nomura M, Hirota T, Iida S, Hara T, Honda S, Kunitoku N, Sasayama T, Arima Y, Marumoto T, Koja K, Yonehara S, Saya H
    • Journal Title

      Oncogene 24

      Pages: 5287-5298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] Overexpression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1.2005

    • Author(s)
      Sasayama, T. et al.
    • Journal Title

      Genes To Cells 10

      Pages: 627-638

    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] Overexpression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1.2005

    • Author(s)
      Sasayama, T. et al.
    • Journal Title

      Genes To Cells 10

      Pages: 627-638

    • Data Source
      KAKENHI-PROJECT-17209049
  • [Journal Article] 癌におけるゲノム不安定性2005

    • Author(s)
      有馬好美、佐谷秀行
    • Journal Title

      ゲノム医学(メディカルレビュー社) 5

      Pages: 115-119

    • Data Source
      KAKENHI-PROJECT-17013070
  • [Journal Article] Overexpression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B12005

    • Author(s)
      Sasayama, T. et al.
    • Journal Title

      Genes To Cells 10

      Pages: 627-638

    • Data Source
      KAKENHI-PROJECT-17659096
  • [Journal Article] PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.2004

    • Author(s)
      Feng L, Yunoue S, Tokuo H, Ozawa T, Zhang D, Patrakitkomjorn S, Ichimura T, Saya H, Araki N^*.
    • Journal Title

      FEBS Lett. 557(1-3)

      Pages: 275-282

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390413
  • [Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress

    • Author(s)
      Ishizawa J, Kuninaka S, Sugihara E, Naoe H, Kobayashi Y, Chiyoda T, Ueki A, Araki K, Yamamura KI, Matsuzaki Y, Nakajima H, Ikeda Y, Okamoto S, Saya H
    • Journal Title

      Cancer Sci.

      Volume: (in press)

    • NAID

      10029293305

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Patent] がん幹細胞の増殖抑制剤および細胞内活性酸素蓄積誘導剤2014

    • Inventor(s)
      永野修、佐谷秀行、岡崎章悟
    • Industrial Property Rights Holder
      永野修、佐谷秀行、岡崎章悟
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-01-29
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Patent] 抗腫瘍剤2011

    • Inventor(s)
      佐谷秀行、永野修、益子高、丹羽眞一郎
    • Industrial Property Rights Holder
      学校法人慶應義塾、学校法人近畿大学、リンク・ジェノミクス(株)
    • Filing Date
      2011-01-13
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Patent] in vitro Fibrotic Focus モデル及び、それを用いた治療薬評価システム2007

    • Inventor(s)
      佐谷秀行、永野修、丹羽眞一郎、中村賢志、鈴木良美
    • Industrial Property Rights Holder
      学校法人 慶應義塾、リンク・ジェノミクス(株)
    • Industrial Property Number
      2007-209591
    • Filing Date
      2007-08-10
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Patent] In vitro Fibrotic Focusモデル及び、それを用いた治療薬評価システム2007

    • Inventor(s)
      佐谷 秀行、永野 修、丹羽 真一郎、中村 賢志、鈴木 良美
    • Industrial Property Rights Holder
      学校法人慶慮義塾、リンク・ジェノミクス株式会社
    • Industrial Property Number
      2007-209591
    • Filing Date
      2007-08-10
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Patent] In vitro Fibrotic Focusモデル及び、それを用いた治療薬評価システム2007

    • Inventor(s)
      佐谷秀行、永野修、丹羽眞一郎、中村賢志、鈴木良美
    • Industrial Property Rights Holder
      学校法人慶應義塾、リンク・ジェノミクス株式会社
    • Industrial Property Number
      2007-209591
    • Filing Date
      2007-08-10
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Patent] 細胞周期作用物質2005

    • Inventor(s)
      佐谷 秀行 他2名
    • Industrial Property Rights Holder
      熊本大学, リンク・ジェノミクスKK
    • Industrial Property Number
      2005-115926
    • Filing Date
      2005-04-13
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Patent] 細胞周期作用物質2005

    • Inventor(s)
      佐谷 秀行, 他2名
    • Industrial Property Rights Holder
      熊本大学, リンク・ジェノミクスKK.
    • Industrial Property Number
      2005-115926
    • Filing Date
      2005-04-13
    • Data Source
      KAKENHI-PROJECT-17209049
  • [Patent] 細胞周期作用物質2005

    • Inventor(s)
      佐谷 秀行, 他2名
    • Industrial Property Rights Holder
      熊本大学, リンク・ジェノミクスKK
    • Industrial Property Number
      2005-115926
    • Filing Date
      2005-04-13
    • Data Source
      KAKENHI-PROJECT-17659096
  • [Presentation] Inhibition of MKL1 enhances the effects of anticancer drugs in chemoresistant osteosarcoma cells2022

    • Author(s)
      信末博行, 清水孝恒, 高橋信博, 山口さやか, 杉原英志, 大西伸幸, 佐谷秀行
    • Organizer
      第81回 日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H00518
  • [Presentation] Therapeutic strategies based on actin cytoskeleton dynamics for targeting chemoresistant osteosarcoma stem cells2022

    • Author(s)
      信末博行, 清水孝恒, 高橋信博, 山口さやか, 杉原英志, 大西伸幸, 佐谷秀行
    • Organizer
      第12回 日米癌合同会議
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H00518
  • [Presentation] FOXA1 suppresses oral cancer progression through inhibiting p38 activation induced by lipid-derived aldehydes2022

    • Author(s)
      岡崎 章悟 、吉川 桃子 、相馬 智也 、莇生田 整治、今井 健一、後飯塚 僚、佐谷 秀行、永野 修
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K10344
  • [Presentation] FOXA1 suppresses oral cancer progression through inhibiting p38 activation induced by lipid-derived aldehydes2022

    • Author(s)
      岡崎 章悟, 吉川 桃子, 相馬 智也, 莇生田 整治, 今井 健一, 後飯塚 僚, 佐谷 秀行, 永野 修
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K10103
  • [Presentation] FOXA1 suppresses oral cancer progression through inhibiting p38 activation induced by lipid-derived aldehydes2022

    • Author(s)
      岡崎 章悟, 吉川 桃子, 相馬 智也, 莇生田 整治, 今井 健一, 後飯塚 僚, 佐谷 秀行, 永野 修
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K10200
  • [Presentation] Role of actin dynamics in cell fate plasticity of microenvironmental cells2019

    • Author(s)
      Hideyuki Saya
    • Organizer
      11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Biology to Precision Medicine
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01401
  • [Presentation] Benzaldehydeは腫瘍細胞における14-3-3ζ;の高発現を介してAMPK活性を亢進させる2019

    • Author(s)
      齋藤 潤、大西 伸幸、杉原 英志、岡崎 章悟、信末 博行、笠間 隆志、佐谷 秀行
    • Organizer
      第78回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-19K22568
  • [Presentation] 舌に発生した紡錘細胞癌は間葉系幹細胞の性質をもつ2019

    • Author(s)
      吉川桃子、黄地健仁、森川暁、高橋萌、相馬智也、宮下英高、河奈裕正、佐谷秀行、中川種昭、莇生田整治
    • Organizer
      第64回 日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-19K10344
  • [Presentation] 口腔に発生した再発紡錘細胞癌における間葉系幹細胞の同定2019

    • Author(s)
      吉川桃子、黄地健仁、森川暁、芝田晋介、高橋萌、相馬智也、宮下英高、村岡渡、亀山香織、河奈裕正、有馬好美、佐谷秀行、岡野栄之、中川種昭、莇生田整治
    • Organizer
      第43回 日本頭頸部癌学会
    • Data Source
      KAKENHI-PROJECT-19K10344
  • [Presentation] 口腔扁平上皮癌を含めたがん幹細胞について基礎からトレンドまで2016

    • Author(s)
      佐谷秀行
    • Organizer
      (公社)日本口腔外科学会第45回教育研修会 (2016 年口腔四学会合同研修会)
    • Place of Presentation
      鶴見大学記念館(神奈川県横浜市)
    • Year and Date
      2016-02-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-25462930
  • [Presentation] 腫瘍組織の不均一性に基づく治療抵抗性とその治療戦略2015

    • Author(s)
      佐谷秀行
    • Organizer
      第29回中国四国脳腫瘍研究会
    • Place of Presentation
      愛媛県県民文化会館(愛媛県松山市)
    • Year and Date
      2015-09-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Presentation] がん幹細胞の特性解析と標的治療2015

    • Author(s)
      佐谷秀行
    • Organizer
      第13回日本臨床腫瘍学会学術集会
    • Place of Presentation
      札幌市教育文化会館(北海道札幌市)
    • Year and Date
      2015-07-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K14384
  • [Presentation] がん幹細胞を標的とした治療戦略2015

    • Author(s)
      佐谷秀行
    • Organizer
      第25回日本サイトメトリー学会学術集会
    • Place of Presentation
      ソラシティーカンファレンスセンター(東京都千代田区)
    • Year and Date
      2015-07-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K14384
  • [Presentation] 脳腫瘍の病態と未来の癌治療2015

    • Author(s)
      佐谷秀行
    • Organizer
      第18回日本臨床脳神経外科学会
    • Place of Presentation
      ホテルオークラ神戸(兵庫県神戸市)
    • Year and Date
      2015-07-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Presentation] がん幹細胞を標的とする新たながん治療開発の展望2015

    • Author(s)
      佐谷秀行
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府左京区)
    • Year and Date
      2015-10-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K14384
  • [Presentation] がん幹細胞を標的とした治療戦略2015

    • Author(s)
      佐谷秀行
    • Organizer
      第56回日本臨床細胞学会総会春期大会
    • Place of Presentation
      くにびきメッセ/松江テルサ(島根県松江市)
    • Year and Date
      2015-06-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Presentation] New mouse lymphoma model reveals the requirement for Fas downregulation in initiation and maintenance of lymphoma cells2015

    • Author(s)
      杉原英志、橋本典愉、植野さやか、清水孝恒、佐谷秀行
    • Organizer
      第74回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15K14384
  • [Presentation] セツキシマブ耐性口腔扁平上皮癌細胞に対する治療の可能性2015

    • Author(s)
      吉川桃子, 莇生田整治, 森川暁, 宮下英高, 臼田慎, 河奈裕正, 中川種昭, 佐谷秀行, 永野修
    • Organizer
      第33回日本口腔腫瘍学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2015-01-30
    • Data Source
      KAKENHI-PROJECT-25462930
  • [Presentation] Heterogeneity and plasticity of cancer metabolism2015

    • Author(s)
      Saya H
    • Organizer
      74th Annual Meeting of Japanese Cancer Association
    • Place of Presentation
      Nagoya Congress Center (Aichi Prefecture, Nagoya)
    • Year and Date
      2015-10-08
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Presentation] Therapeutic strategies targeting cancer stem cells2015

    • Author(s)
      Saya H
    • Organizer
      The 3rd Beijing International Symposium on Tumor Microenvironment
    • Place of Presentation
      Beijing (China)
    • Year and Date
      2015-05-17
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Presentation] Novel mouse model for mature B cell lymphoma reveals the requirement for Fas downregulation in lymphomagenesis.2015

    • Author(s)
      Sugihara E, Hashimoto N, Ueno S, Saya H
    • Organizer
      American Association for Cancer Research Annual meeting
    • Place of Presentation
      Philadelphia, USA.
    • Year and Date
      2015-04-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14384
  • [Presentation] がん幹細胞の代謝不均一性2015

    • Author(s)
      佐谷秀行
    • Organizer
      第13回日本プロテオーム学会
    • Place of Presentation
      くまもと森都心プラザ(熊本県熊本市)
    • Year and Date
      2015-07-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K14384
  • [Presentation] New mouse model for mature B cell lymphoma revealing requirement for Fas downregulation in lymphomagenesis.2015

    • Author(s)
      Sugihara E, Hashimoto N, Ueno S, Saya H
    • Organizer
      20th Congress of European Hematology Association
    • Place of Presentation
      Vienna, Austria.
    • Year and Date
      2015-06-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14384
  • [Presentation] 薬剤スクリーニングに用いる癌遺伝子HRAS導入メダカモデルの確立2014

    • Author(s)
      松崎ゆり子・佐谷秀行
    • Organizer
      日本癌学会
    • Place of Presentation
      神奈川・パシフィコ横浜
    • Year and Date
      2014-09-26
    • Data Source
      KAKENHI-PROJECT-24591633
  • [Presentation] がん幹細胞を標的とした治療戦略2014

    • Author(s)
      佐谷秀行
    • Organizer
      第18回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルメトロポリタン仙台、仙台
    • Year and Date
      2014-06-25
    • Invited
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Presentation] Mechanisms of adaptive radioprotection in glioma stem cells2014

    • Author(s)
      Hideyuki Saya
    • Organizer
      20th International Conference on Brain Tumor Research and Therapy
    • Place of Presentation
      Lake Tahoe, USA
    • Year and Date
      2014-07-21
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Presentation] 骨肉腫幹細胞の性状解析と分化制御による治療戦略の考案2014

    • Author(s)
      佐谷秀行
    • Organizer
      第56回日本小児血液・がん学会学術集会
    • Place of Presentation
      岡山コンベンションセンター、岡山
    • Year and Date
      2014-11-29
    • Invited
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Presentation] CD44v9 results in resistance to trastuzumab via induction of ROS resistance2014

    • Author(s)
      Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Masaoka, T., Kanai, T., Saya, H.
    • Organizer
      Digestive Disease Week 2014
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-05-03
    • Data Source
      KAKENHI-PROJECT-25293178
  • [Presentation] がん幹細胞の代謝特性2014

    • Author(s)
      佐谷 秀行
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Presentation] 脳腫瘍幹細胞の性状解析に基づく治療戦略の考案2014

    • Author(s)
      佐谷 秀行
    • Organizer
      第32回脳腫瘍病理学会
    • Place of Presentation
      徳島県徳島市
    • Year and Date
      2014-05-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Presentation] Establishment of transgenic HRAS medaka as a tumor model for in vivo drug screening2014

    • Author(s)
      松崎ゆり子・佐谷秀行他
    • Organizer
      小型魚類研究会
    • Place of Presentation
      慶應義塾大学薬学部
    • Year and Date
      2014-09-20
    • Data Source
      KAKENHI-PROJECT-24591633
  • [Presentation] Therapeutic strategies for targeting cancer stem cells.2013

    • Author(s)
      佐谷秀行
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Invited
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Presentation] CD44 and gastric epithelial stem cells.2013

    • Author(s)
      Hideyuki Saya
    • Organizer
      6th Annual Scientific Meeting, Singapore Gastric Cancer Consortium.
    • Place of Presentation
      Singapore
    • Invited
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Presentation] Roles of CD44 in cancer stem cells.2013

    • Author(s)
      Hideyuki Saya
    • Organizer
      The American Association for Cancer Research (AACR) Annual Meeting 2013
    • Place of Presentation
      Washington DC, USA
    • Invited
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Presentation] 口腔癌細胞の腫瘍形成におけるCD44v-xCTの機能的役割2013

    • Author(s)
      吉川桃子, 永野修, 莇生田整治, 中川種昭, 河奈裕正, 佐谷秀行
    • Organizer
      第31回日本口腔腫瘍学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22592100
  • [Presentation] がん幹細胞マーカーCD44とPKM2の相互作用を介した糖代謝制御2013

    • Author(s)
      玉田真由美、末松誠、佐谷秀行
    • Organizer
      第1回がんと代謝研究会
    • Place of Presentation
      鶴岡メタボロームキャンパスレクチャーホール(山形県)
    • Data Source
      KAKENHI-PROJECT-25870717
  • [Presentation] Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells2013

    • Author(s)
      Mayumi Tamada, Makoto Suematsu, Hideyuki Saya
    • Organizer
      American Association for Cancer Research (AACR) Annual Meeting 2013
    • Place of Presentation
      Washington Convention Center
    • Data Source
      KAKENHI-PROJECT-25870717
  • [Presentation] Novel strategies for targeting cancer stem cells.2013

    • Author(s)
      Saya H
    • Organizer
      Ninth AACR-Japanes Cancer Association Joint Conference
    • Place of Presentation
      Hawaii,米国
    • Invited
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Presentation] Novel therapeutic strategies for cancer stem cells.2013

    • Author(s)
      Hideyuki Saya
    • Organizer
      The 39th Annual Meeting of Korean Cancer Association.
    • Place of Presentation
      Seoul, Korea
    • Invited
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Presentation] Invasive and radio-resistant characteristics of glioma stem cells2013

    • Author(s)
      Saya H
    • Organizer
      10th Asian Society for NeuroOncology (ASNO) Conference
    • Place of Presentation
      Mumbai, India
    • Invited
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Presentation] A novel therapeutic approach targeting the CD44 variant functions.2012

    • Author(s)
      Saya H
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Presentation] Characterization of brain tumor stem cells using induced cancer stem cell (iCSC) technology2012

    • Author(s)
      Saya H
    • Organizer
      Korean Neuro-Oncology Meeting
    • Place of Presentation
      Gyeonggi-do, Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Presentation] Characterization of brain tumor stem cells using induced cancer stem cell (iCSC) technology.2012

    • Author(s)
      Saya H
    • Organizer
      Invited Lecture, Korean Neuro-Oncology Meeting.
    • Place of Presentation
      Gyeonggi-do, Korea
    • Year and Date
      2012-09-22
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Presentation] Invasive and radio-resistant characteristics of glioma stem cells2012

    • Author(s)
      Saya H
    • Organizer
      10th Asian Society for NeuroOncology (ASNO)conference
    • Place of Presentation
      Mumbai, India
    • Year and Date
      2012-03-22
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Presentation] シーズ探索その1「大学における基礎研究を創薬に結び付けるために」2012

    • Author(s)
      佐谷秀行
    • Organizer
      第12回抗悪性腫瘍開発フォーラム
    • Place of Presentation
      東京都、吉田富三記念講堂、がん研究会がん研究所
    • Year and Date
      2012-02-18
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Presentation] xCT シスチントランスポーターの阻害はCD44 バリアント陽性扁平上皮癌細胞の生体内における拡大を抑制する.2012

    • Author(s)
      吉川桃子, 永野修, 土橋賢治, 莇生田整治, 中川種昭, 佐谷秀行
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22592100
  • [Presentation] 悪性脳腫瘍幹細胞の浸潤能の解析2011

    • Author(s)
      サンペトラ オルテア、佐谷秀行
    • Organizer
      第29回日本脳腫瘍学会
    • Place of Presentation
      下呂温泉水明館(岐阜)
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Presentation] グリオーマ幹細胞モデルを用いた薬剤抵抗性克服2011

    • Author(s)
      サンペトラ オルテア、佐谷秀行
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Presentation] HRAS^<G12V> transgenic medaka fish develop melanoma with high frequency2011

    • Author(s)
      松崎ゆり子, 佐谷秀行, 他
    • Organizer
      The 1^<st> strategic meeting for medaka research
    • Place of Presentation
      愛知県: Okazaki conference center
    • Year and Date
      2011-11-23
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Presentation] New strategies in glioblastoma treatment-insights from the induced cancer stem cell (iCSC) model2011

    • Author(s)
      Sampetrean O, Saya H
    • Organizer
      Taipei VGH and NYMU Brain Tumor Symposium 2011
    • Place of Presentation
      Taipei, Taiwan(招待講演)
    • Year and Date
      2011-11-30
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Presentation] がん幹細胞の性質を制御する分子機構とその治療戦略2011

    • Author(s)
      佐谷秀行
    • Organizer
      CBI学会第316回研究講演会
    • Place of Presentation
      東京都、総評会館
    • Year and Date
      2011-04-18
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Presentation] Role of CD44 in cancer stem cells and metastasis2011

    • Author(s)
      Saya H
    • Organizer
      8^<th> International Symposium on Minmal Residual Cancer
    • Place of Presentation
      Osaka International Convention Center, Osaka
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Presentation] HRAS^<G12V> transgenic medaka fish develop melanoma with high frequency2011

    • Author(s)
      松崎ゆり子, 佐谷秀行
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知県:名古屋国際会議場
    • Year and Date
      2011-10-04
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Presentation] Role of CD44 in Cancer Stem Cells.2011

    • Author(s)
      Saya H
    • Organizer
      The 29^<th> Nagoya International Cancer Treatment Symposium.
    • Place of Presentation
      愛知がんセンター(愛知県)
    • Year and Date
      2011-02-11
    • Data Source
      KAKENHI-PROJECT-22650229
  • [Presentation] Role of CD44 in cancer stem cells and metastasis. Prenary Lecture52011

    • Author(s)
      Saya H
    • Organizer
      8^<th> International Symposium on Residual Cancer
    • Place of Presentation
      Osaka
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-23650601
  • [Presentation] Role of CD44 in Cancer Stem Cells.2011

    • Author(s)
      Saya H
    • Organizer
      The 29^<th> Nagoya International Cancer Treatment Symposium.
    • Place of Presentation
      愛知がんセンター(愛知県)
    • Year and Date
      2011-02-11
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Presentation] Role of CD44 in cancer stem cells and metastasis2011

    • Author(s)
      Saya H
    • Organizer
      8^<th> International Symposium on Minmal Residual Cancer
    • Place of Presentation
      Osaka International Convention Center, Osaka(招待講演)
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Presentation] がん幹細胞の治療抵抗性メカニズム2011

    • Author(s)
      佐谷秀行
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知県:名古屋国際会議場
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Presentation] 癌幹細胞の治療抵抗性を制御する分子機構。パネルディスカッション3「がん幹細胞研究の進展と治療展開」2011

    • Author(s)
      佐谷秀行
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      愛知県、名古屋国際会議場
    • Year and Date
      2011-10-27
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Presentation] Role of CD44 in cancer stem cells and metastasis2011

    • Author(s)
      Saya H
    • Organizer
      Plenary Lecture 5, 8^<th> International Symposium on Minmal Residual Cancer
    • Place of Presentation
      Osaka International Convention Center, Osaka(招待講演)
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-23650601
  • [Presentation] 動物モデルを用いた癌幹細胞の性状解析2010

    • Author(s)
      佐谷秀行
    • Organizer
      第19回泌尿器科分子・細胞研究会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2010-02-20
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] Role of CD44 hyaluronan receptor in cancer stem cells.2010

    • Author(s)
      Saya H
    • Organizer
      8^<th> International Conference on Hyaluronan.The International Society for Hyaluronan Sciences(ISHAS).
    • Place of Presentation
      京都ブライトンホテル
    • Year and Date
      2010-06-09
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Presentation] Significance of epithelial mesenchymal transition (EMT) in cancer malignancy.2010

    • Author(s)
      Hideyuki Saya
    • Organizer
      6^<th> Annual Conference of OOTR.
    • Place of Presentation
      The Westin Miyako Hotel
    • Year and Date
      2010-02-06
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] New melanoma model using transgenic medaka fish2010

    • Author(s)
      松崎ゆり子, 佐谷秀行, 他
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      兵庫県:神戸国際会議場
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Presentation] Role of CD44 hyaluronan receptor in cancer stem cells2010

    • Author(s)
      Saya H
    • Organizer
      8th International Conference on Hyaluronan. The International Society for Hyaluronan Sciences (ISHAS)
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-06-09
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Presentation] 誘導型がん幹細胞の解析と応用2010

    • Author(s)
      佐谷秀行
    • Organizer
      第51回日本臨床細胞学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-05-31
    • Data Source
      KAKENHI-PROJECT-22249055
  • [Presentation] メダカ悪性黒色腫モデル系の構築2010

    • Author(s)
      松崎ゆり子, 佐谷秀行, 他
    • Organizer
      第16回小型魚類研究会
    • Place of Presentation
      埼玉県:プラザイースト
    • Year and Date
      2010-09-19
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Presentation] Novel Strategy for Glioma Invasion.2010

    • Author(s)
      Saya H
    • Organizer
      7^<th> Meeting of Asian Society for Neuro-Oncology (ASNO).
    • Place of Presentation
      JW Marriott Hotel (Seoul, Korea)
    • Year and Date
      2010-06-11
    • Data Source
      KAKENHI-PROJECT-22650229
  • [Presentation] 上皮間葉転換の腫疫における意義2009

    • Author(s)
      佐谷秀行
    • Organizer
      第15回日本家族性腫瘍学会学術集会
    • Place of Presentation
      秋葉原コンベンションホール
    • Year and Date
      2009-06-12
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 遺伝子改変メダカを用いた発癌モデルの構築2009

    • Author(s)
      松崎ゆり子, 佐谷秀行
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      神奈川県:横浜国際会議場
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Presentation] マウス腫瘍形成モデルを用いたがん幹細胞の解析2009

    • Author(s)
      佐谷秀行
    • Organizer
      癌治療開発&先端医療開発を目指した最前線セミナー
    • Place of Presentation
      秋葉原UDX Gallery
    • Year and Date
      2009-05-18
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] Analysis of Myc-induced cancer stem cell models2009

    • Author(s)
      Saya H
    • Organizer
      USA-Japan Cooperative Cancer Workshop 'Stem Cells in Normal and Malignant Hematopoiesis'
    • Place of Presentation
      Hilton Waikoloa Village in Hawaii Big Island.Hawaii
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] 動物モデルを用いたがん幹細胞の解析と応用2009

    • Author(s)
      佐谷秀行
    • Organizer
      北海道癌談話会春期シンポジウム
    • Place of Presentation
      小樽商科大学札幌サテライト
    • Year and Date
      2009-06-27
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 癌幹細胞誘導研究によって得られた細胞癌化機構の新たな知見2009

    • Author(s)
      佐谷秀行
    • Organizer
      再生医療の実現化プロジェクト、第2回夏のワークショップ
    • Place of Presentation
      熱海KKRホテル
    • Year and Date
      2009-07-16
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] マウスモデルを用いた癌幹細胞の性状解析と応用。シンポジウム3がん幹細胞2009

    • Author(s)
      佐谷秀行
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京国際フォーラム。東京
    • Year and Date
      2009-03-05
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] がん浸潤転移を標的とした治療の開発戦略2009

    • Author(s)
      佐谷秀行
    • Organizer
      平成21年度政策創薬総合研究推進事業第35回ヒューマンサイエンス総合研究セミナー「次世代の抗がん剤創薬に向けて」
    • Place of Presentation
      全国社会福祉協議会・灘尾ホール
    • Year and Date
      2009-11-10
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 動物モデルを用いたがん幹細胞の解析と応用2009

    • Author(s)
      佐谷秀行
    • Organizer
      第10回検査血液学会学術集会
    • Place of Presentation
      山梨大学甲府キャンパス
    • Year and Date
      2009-07-04
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 動物モデルを用いたがん幹細胞の解析と応用2009

    • Author(s)
      佐谷秀行
    • Organizer
      第31回本郷呼吸器研究会
    • Place of Presentation
      山の上ホテル
    • Year and Date
      2009-06-23
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] メダカを用いた悪性黒色腫モデル系の構築2009

    • Author(s)
      松崎ゆり子, 佐谷秀行
    • Organizer
      第15回小型魚類研究会
    • Place of Presentation
      愛知県名古屋大学野依記念学術交流館
    • Year and Date
      2009-09-12
    • Data Source
      KAKENHI-PROJECT-21591444
  • [Presentation] 癌の浸潤転移に関わる分子イベント2009

    • Author(s)
      佐谷秀行、永野修
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-05-01
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 動物モデルを用いたがん幹細胞の解析と応用2009

    • Author(s)
      佐谷秀行
    • Organizer
      第71回大腸癌研究会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2009-07-03
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 誘導性腫瘍形成モデルを用いたがん幹細胞の解析2009

    • Author(s)
      佐谷秀行
    • Organizer
      第11回泌尿器疾患ゲノム解析研究会
    • Place of Presentation
      大阪リーガロイヤルホテル。大阪(招待講演)
    • Year and Date
      2009-03-14
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] 癌幹細胞理論に基づく腫瘍治療戦略のパラダイムシフト2009

    • Author(s)
      佐谷秀行
    • Organizer
      第10回日本分子脳神経外科学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2009-09-20
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 癌幹細胞モデルの作製と応用。ランチョンセミナー2009

    • Author(s)
      佐谷秀行
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場。名古屋
    • Year and Date
      2009-10-30
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] マウス正常細胞より誘導した癌幹細胞様細胞を用いた治療抵抗性機構の解析2009

    • Author(s)
      佐谷秀行
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフイコ横浜
    • Year and Date
      2009-10-03
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 動物モデルを用いたがん幹細胞の特性解析と治療戦略の考案2009

    • Author(s)
      佐谷秀行
    • Organizer
      第61回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      B-CON PLAZA別府国際コンベンションセンター
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] Role of Hyaluronan-CD44 Interaction in Epithelial-Mesenchymal Transition and Cancer Invasion2009

    • Author(s)
      Saya H
    • Organizer
      Invited Speaker. Global Center of Excellence (COE) Program 1^<st> International Symposium
    • Place of Presentation
      Nagoya University School of Medicine.Nagoya
    • Year and Date
      2009-01-23
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] Drug Development for Cancer Cell Migration.2009

    • Author(s)
      Hideyuki Saya
    • Organizer
      The International Symposium of Pediatric Neuro-oncology for the 50th Anniversary of Taipei Veterans General Hospital and the Annual Scientific Meeting of Chinese Medical Association.
    • Place of Presentation
      Taipei Veterans General Hospital
    • Year and Date
      2009-10-31
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] Role of Hyaluronan-CD44 Interaction in Epithelial-Mesenchymal Transition and Cancer Invasion.2009

    • Author(s)
      Saya H.
    • Organizer
      Global Center of Excellence (GCOE)Program 1^<st> International Symposium
    • Place of Presentation
      名古屋
    • Year and Date
      2009-01-23
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] Mouse cancer models using induced cancer stem cells.2009

    • Author(s)
      Hideyuki Saya
    • Organizer
      A Victor A. Levin Lectureship.
    • Place of Presentation
      The University of Texas, M.D. Anderson Cancer Center
    • Year and Date
      2009-11-18
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 癌幹細胞理論に基づく治療戦略の変革2009

    • Author(s)
      佐谷秀行
    • Organizer
      第7回日本乳癌学会近畿地方会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-12-05
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 抗がん剤による細胞死の分子機構2008

    • Author(s)
      佐谷秀行
    • Organizer
      第5回婦人科がん会議
    • Place of Presentation
      宇都宮
    • Year and Date
      2008-05-23
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 癌の浸潤・転移抑制創薬への新しいアプローチ2008

    • Author(s)
      佐谷秀行
    • Organizer
      第12回がん分子標的治療研究会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] 癌の浸潤転移能を決定づける細胞-マトリクス相互作用2008

    • Author(s)
      佐谷秀行
    • Organizer
      第41回日本整形外科学会・骨・軟部腫瘍学術学会
    • Place of Presentation
      浜松
    • Year and Date
      2008-07-18
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] 胎盤からみた細胞周期制御因子APC/cdh1の機能2008

    • Author(s)
      佐谷秀行
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会。シンポジウム。
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] Establishment of osteosarcoma cancer stem cells from mouse bone marrow stromal cells2008

    • Author(s)
      Saya H
    • Organizer
      Invited Speaker. Cancer Genes and Cancer Stem Cells. The 5^<th> Nikko International Symposium 2008
    • Place of Presentation
      Jichi Medical University (JMU) Information and In-service Training Center, Japan
    • Year and Date
      2008-10-25
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] Molecular mechanism of cell death induced by anti-cancer drugs. Invited speaker.2008

    • Author(s)
      Saya H
    • Organizer
      The 15th Takeda Science Foundation Symposium on Bioscience
    • Place of Presentation
      Sheraton Miyako Hotel Tokyo, Tokyo
    • Year and Date
      2008-12-02
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 癌幹細胞に基づく癌発生及び維持機構の解析2008

    • Author(s)
      佐谷秀行
    • Organizer
      第47回日本臨床細胞学会秋期大会
    • Place of Presentation
      東京(要望講演)
    • Year and Date
      2008-11-14
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] 癌の浸潤転移能を決定づける細胞-マトリクス相互作用2008

    • Author(s)
      佐谷秀行
    • Organizer
      第41回日本整形外科学会・骨・軟部腫瘍学術学会
    • Place of Presentation
      浜松(教育講演)
    • Year and Date
      2008-07-18
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] Molecular mechanism of cell death induced by anti-cancer drugs2008

    • Author(s)
      Saya H
    • Organizer
      The 15^<th> Takeda Science Foundation Symposium on Bioscience
    • Place of Presentation
      東京
    • Year and Date
      2008-12-03
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 細胞-マトリクス間相互作用と癌細胞浸潤。ランチョンセミナー2007

    • Author(s)
      佐谷秀行
    • Organizer
      第25回日本ヒト細胞学会学術集会
    • Place of Presentation
      都市センターホテル、東京
    • Year and Date
      2007-08-04
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] 抗がん剤治療の分子メカニズム。Meet the Expert Seminar2007

    • Author(s)
      佐谷秀行
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜。横浜
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] Auroraキナーゼの発がんにおける役割,合同シンポジウム5「シグナル伝達研究と分子標的療法」2007

    • Author(s)
      佐谷秀行
    • Organizer
      第69回日本血液学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] Molecular mechanism of anti-cancer therapies. Luncheon Seminar2007

    • Author(s)
      Saya H
    • Organizer
      Organization for Oncology and Translational Research 4^<th> Annual Conference
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] 癌幹細胞について解決すべき諸問題。シンポジウム2007

    • Author(s)
      佐谷秀行
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] 抗がん剤による細胞死の分子機構2007

    • Author(s)
      佐谷 秀行
    • Organizer
      第69回日本血液学会総会シンポジウム4「細胞死と血液疾患
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-13
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 癌幹細胞について解決すべき諸問題2007

    • Author(s)
      佐谷 秀行
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会シンポジウム3S28「癌幹細胞一組織幹細胞と何が似て、何が違うか」
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-11
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] Molecular mechanism of anti-cancer therapies. Special Lecture.2007

    • Author(s)
      Saya H
    • Organizer
      International Symposium on 50th Anniversary of Yonsei University
    • Place of Presentation
      Yonsei University College of Medicine, Seoul, Korea
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] 抗がん剤による細胞死の分子機構。シンポジウム4「細胞死と血液疾患」2007

    • Author(s)
      佐谷秀行
    • Organizer
      第69回日本血液学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19209048
  • [Presentation] Role of Aurora kinases in mitotic regulation and tumorigenesis.2005

    • Author(s)
      Saya H
    • Organizer
      Plenary Lecture. Annual meeting of the Korean Society of Medical Biochemistry and Molecular Biology
    • Place of Presentation
      Seoul, Korea
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] Dynamic analysis of mitotic catastrophe.2005

    • Author(s)
      Saya H
    • Organizer
      International Symposium on "DNA replication and cell cycle"
    • Place of Presentation
      Tokyo University, Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] Molecular understanding and dynamic analysis of anti-cancer therapy. Special Lecture (Prof. Takao Hoshino's Memorial Lecture).2005

    • Author(s)
      Saya H
    • Organizer
      4th Meeting of the Asian Society of Neuro-Oncology
    • Place of Presentation
      Taipei, Taiwan
    • Data Source
      KAKENHI-PROJECT-17013070
  • [Presentation] グリオーマの基礎生物学

    • Author(s)
      佐谷秀行
    • Organizer
      第33回日本脳神経外科コングレス総会
    • Place of Presentation
      大阪国際会議場
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Presentation] Autophagy causing CagA degradation is triggered by cytoplasmic accumulation of low-density lipoprotein receptor-related protein-1 (LRP1) in gastric epithelial cells infected with H. pylori.

    • Author(s)
      Tsugawa, H., Matsuzaki, J., Okada, S., Fukuhara, S., Mori, H., Masaoka, T., Sato, A., Saya, H., Hatakayama, M., Hirayama, T., Suzuki, H.
    • Organizer
      UEGW2013
    • Place of Presentation
      Berlin
    • Data Source
      KAKENHI-PROJECT-25293178
  • [Presentation] xCT標的治療はCD44v陽性口腔扁平上皮癌細胞を選択的に死滅させる

    • Author(s)
      吉川桃子, 莇生田整治, 河奈裕正, 中川種昭, 佐谷秀行
    • Organizer
      第58回(社)日本口腔外科学会総会, 福岡, 2013.10.
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-25462930
  • [Presentation] CD44v9 play a role to anti-tumor effect against human gastric cancer by trastuzumab.

    • Author(s)
      Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Masaoka, T., Kanai, T., Saya, H.
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      Urayasu
    • Data Source
      KAKENHI-PROJECT-25293178
  • [Presentation] Regulation of cell differentiation by actin dynamics and its application in cancer treatment.

    • Author(s)
      Hideyuki Saya
    • Organizer
      Aichi Cancer Center 50th Anniversary International Symposium.
    • Place of Presentation
      Aichi Cancer Center, Nagoya
    • Year and Date
      2015-03-13 – 2015-03-14
    • Data Source
      KAKENHI-PLANNED-22130007
  • [Presentation] 抗癌剤スクリーニングに用いるための遺伝子導入メダカ腫瘍モデルの確立

    • Author(s)
      松崎ゆり子・佐谷秀行
    • Organizer
      日本動物学会
    • Place of Presentation
      岡山県岡山市
    • Data Source
      KAKENHI-PROJECT-24591633
  • [Presentation] Expression of CD44 Variant 9 Contributes to 5-Fluorouracil Resistance in Gastric Cancer Trough Anti-Oxidative Stress Mechanism.

    • Author(s)
      Okada, S., Suzuki, H., Masaoka, T., Tsugawa, H., Matsuzaki, J., Fukuhara, S., Hirata, K., Mori, H., Saya, H., Hibi, T.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando
    • Data Source
      KAKENHI-PROJECT-25293178
  • [Presentation] xCT inhibition depletes CD44v-expressing squamous cell carcinoma cells that are resistant to EGFR-targeted therapy

    • Author(s)
      Momoko Yoshikawa, Osamu Nagano, Kenji Tsuchihashi, Seiji Asoda, Hiromasa Kawana, Taneaki Nakagawa, Hideyuki Saya
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25462930
  • [Presentation] Novel Therapeutic Strategies for Cancer Stem Cells.

    • Author(s)
      Hideyuki Saya
    • Organizer
      Weatherall Institute of Molecular Medicine (WIMM) Seminar
    • Place of Presentation
      University of Oxford, UK
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Presentation] Roles of CD44 in cancer stem cells.

    • Author(s)
      Hideyuki Saya
    • Organizer
      The American Association for Cancer Research (AACR) Annual Meeting 2013
    • Place of Presentation
      Washington, DC, USA
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-22130001
  • [Presentation] Establishment of transgenic medaka as a stable tumor model for in vivo screening of anticancer drugs

    • Author(s)
      松崎ゆり子・細貝春・水口幸代・清水厚志・佐谷秀行
    • Organizer
      アメリカ癌学会
    • Place of Presentation
      米国・ワシントンDC
    • Data Source
      KAKENHI-PROJECT-24591633
  • [Presentation] Novel therapeutic strategies for cancer stem cells

    • Author(s)
      Saya Hideyuki
    • Organizer
      The 39th Annual Meeting of Korean Cancer Association
    • Place of Presentation
      Seoul, Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253085
  • [Presentation] Establishment of the medaka melanoma model and drug administration trials

    • Author(s)
      Hosokai H, Shimizu A, Saya H, Fukamachi S, Mizuguchi Y, Matsuzaki Y
    • Organizer
      第18回小型魚類研究会
    • Place of Presentation
      京都大学(京都)
    • Data Source
      KAKENHI-PROJECT-24591633
  • [Presentation] H. pyloriがん蛋白質CagAのCD44v9発現がん幹細胞特異的蓄積メカニズムの発見

    • Author(s)
      津川仁、鈴木秀和、佐谷秀行、松崎潤太郎、平田賢郎、福原誠一郎、岡田佐和子、正岡建洋、畠山昌則、平山壽哉、日比紀文
    • Organizer
      第19回日本ヘリコバクター学会学術集会
    • Place of Presentation
      長崎
    • Data Source
      KAKENHI-PROJECT-25293178
  • [Presentation] Expression of CD44 variant 9 contributes to 5-fluorouracil resistance in gastric cancer through anti-oxidative stress mechanism

    • Author(s)
      Miyoshi, S., Suzuki, H., Tsugawa, H., Masaoka, T., Matsuzaki, J., Fukuhara, S., Hirata, K., Mori, H., Kanani, T., Saya, H.
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-25293178
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    # of Collaborated Projects: 15 results
    # of Collaborated Products: 4 results
  • 2.  ASODA Seiji (80296706)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 11 results
  • 3.  YOSHIKAWA Momoko (50570967)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 11 results
  • 4.  MIMORI Tatsuyuki (00117384)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 5.  NISHI Toru (00264309)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  NAGAHAMA Yoshitaka (50113428)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  KURATSU Juniti (20145296)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  ISHIKAWA Fuyuki (30184493)
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  • 9.  MATSUZAKI Yuriko (40255435)
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  • 11.  KOCHI Masato (70178218)
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    # of Collaborated Products: 0 results
  • 12.  竹島 秀雄 (70244134)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 13.  信末 博行 (90525685)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 14.  NODA Tetsuo (10183550)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 15.  HANAOKA Fumio (50012670)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 2 results
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    # of Collaborated Projects: 2 results
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    # of Collaborated Projects: 2 results
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  • 19.  SASAOKA Toshikuni (50222005)
    # of Collaborated Projects: 2 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 22.  SAMPETREAN Oltea (50571113)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 15 results
  • 23.  SUGIHARA Eiji (50464996)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 24.  廣瀬 雄一 (60218849)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 25.  黄地 健仁 (30803564)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 47.  SASAKI Yutaka (70235282)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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