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Shinomura Yasuhisa  篠村 恭久

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… Alternative Names

SHINOMURA Yasuhisa  篠村 恭久

篠村 泰久  シノムラ ヤスヒサ

篠村 恭久  シノムラ ヤスヒサ

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Researcher Number 90162619
Other IDs
Affiliation (Current) 2025: 札幌医科大学, その他部局等, 名誉教授
Affiliation (based on the past Project Information) *help 2015 – 2017: 札幌医科大学, その他部局等, 名誉教授
2005 – 2015: Sapporo Medical University, School of Medicine, Professor, 医学部, 教授
1999 – 2004: Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授
2001: 大阪大学, 医学系研究科, 助手
1997 – 1998: 大阪大学, 医学部, 助教授
1993 – 1996: 大阪大学, 医学部, 講師
1988: 大阪大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology
Except Principal Investigator
Gastroenterology / Gastroenterology / 内分泌・代謝学 / Cancer epidemiology and prevention
Keywords
Principal Investigator
c-kit / メチル化 / 胃癌 / GIST / 遺伝子変異 / CD9 / HB-EGF / IL-1 / Helicobacter pylori / mutation … More / 平滑筋腫 / ゲノム / エピジェネティクス / HOTAIR / エピゲノム / 前癌病変 / 遺伝子診断 / マイクロRNA / 大腸癌 / ガストリン / ESD / Fusobacterium / 食道癌 / prediction of cancer risk / genetic diagnosis / epigenetics / methylation / gastrointestinal cancer / 遺伝子不安定性 / 発癌リスク予測 / 消化器癌 / gastritis / gastrin / gastric cancer / PKC / p38-MAPK / NF-κB / 胃炎 / apoptosis / leiomyosarcoma / leimyoma / gastrointestinal stromal tumor / アポトーシス / 平滑筋肉腫 / 消化管腫瘍 / pacemaker / interstitial cells of Cajal / gastrointestinal motility / カハール / 消化管運動異常症 / ペースメーカー / カハール介在細胞 / 消化管運動 / stromal tumor / 消化管間葉腫瘍 / 突然変異 / 消化管間葉系腫瘍 / ChIP-seq / ncRNA / 次世代シークエンサー / non-coding RNA / 癌幹細胞 / 癌間質 / miR-196a / 消化管癌 / 上部消化管学 / H. pylori / H.pylori / LINE-1 / hypomethylation / hypermethylation / Gene expression / 標的遺伝子 / マイクロ RNA / 消化管間質腫瘍 / EGF / HGF / 悪性黒色腫 / 転移 / 酸分泌 / 過形成 / サイトカイン / 肝細胞増殖因子 / インターロイキン-1 / 萎縮性胃炎 / ヘリコバクター・ピロリ / ヒスチジン脱炭酸酵素 / ヒスタミン / インターロイキン1β … More
Except Principal Investigator
胃癌 / HB-EGF / amphiregulin / hepatocyte growth factor / 消化器癌 / 大腸癌 / トランスジェニックマウス / 遺伝子発現 / Akt / tyrosine kinase inhibitor / dominant negative / bFGF / Helicobacter Pylori / p38MAPK / TRAF6 / NIK / protein kinase C / IKK / 胃上皮細胞 / ガストリン / NF-kappaB / CD40 / IL-10 / 分化 / 増殖 / Ets / AP-1 / cyclin D1 / PPARγ / IRF-1 / bak / bcl-xL / ras / STAT3 / アポトーシス / 分子標的 / DNAメチル化 / 胃粘膜 / 胃炎 / ヘリコバクター・ピロリ / がん分子標的薬剤 / ATL発症リスク / ATL発がん機序 / がん化学予防 / 分子疫学コーホート研究 / ATL発症予防 / 国際交流 / 個別化がん予防 / ゲノム・エピゲノム解析支援 / アカデミア創薬 / 次世代分子解析技術 / ゲノムコーホート研究 / 病理形態学 / 遺伝子改変マウス / 国際研究者交流 / 若手支援 / Exercise / Myopathy / Hyperunicemia / Glycogenosis / Hypoxanthine / Unicacid / 運動負荷試験 / 電解質異常 / 甲状腺機能低下症 / ミトコンドリア脳筋症 / グリコーゲン病 / ミオパチー / プリン体代謝 / 筋原性高尿酸血症 / オキシプリン / 運動 / ミオパチ- / 高尿酸血症 / グリコ-ゲン病 / ヒポキサンチン / 尿酸 / IGF- 1 receptor / microsatellite instability / gastrointestinal cancer / extracellular matrix degrading enzyme / insulin-like growth factor / bystander効果 / Akt-1 / IGF-I receptor / ERK / 細胞外基質分解酵素 / IGF1 receptor / マイクロサテライト不安定性 / 細胞外基質分解酵 / インスリン様増殖因子 / regenerative medicine / cell transplantation / trans-differentiation / bone marrow cells / hepatocyte / 再生医療 / 細胞移植療法 / 骨髄間葉系幹細胞 / 肝再生 / 骨髄細胞 / 肝再生療法 / 細胞移植 / pro HB-EGF / GFP / HGF / Gastrin / Proliferation / Differentiation / MMK6 / Gastric Mucosal Cell / 分化・増殖 / MKK6 / gastric epithelial cells / gastrin / H-pylori / H.pylori / lipopolysaccharide / mice / macrophage / Conh's disease / IL-12 / TNFα / エンドトキシン / マウス / マクロファージ / クローン病 / differentiation / growth / 消化管上皮 / Stat3 / Missence mutation / Apoptosis / Colorectal cancer / Gastric cancer / astat3 / アポト-シス / IRF-2 / Star3 / ミスセンス変異 / dominant-negative / apoptosis / EGF-related peptides / EGF receptor / 癌化 / 修復 / ドミナント・ネガティブ / EGF関連ペプチド / EGF受容体 / マイクロRNA / SNP / 分子疫学 / 日米欧比較 / 機能性RNA / 癌 / 分子改変 / 抗体治療 / 肝癌 / 肝臓学 / 腫瘍マーカー / メチル化 / 分子標的治療 / 遺伝子診断 / 個別化医療 / ヒストン修飾 / エピジェネティクス / 粘膜修復 / interleukin-1β / 胃酸 / Amesテスト / 変異原性物質 / ヘリコバクター / 組織修復 / 皺襞腫大 / mRNA / インターロイキン-1 / 胃十二指腸潰瘍 / インターロイキン-1β / 消化性潰瘍 / 細胞毒素 / ヘリバクプター / サイトカイン / 細胞増殖因子 / 培養 / 胃粘膜上皮細胞 Less
  • Research Projects

    (33 results)
  • Research Products

    (220 results)
  • Co-Researchers

    (158 People)
  •  Genome and epigenome analysis of early esophageal cancer and the development of molecular diagnosis using endoscopic washPrincipal Investigator

    • Principal Investigator
      Shinomura Yasuhisa
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Analysis of long non-coding RNAs that predict biological malignancy in GISTPrincipal Investigator

    • Principal Investigator
      SHINOMURA Yasuhisa
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Molecular epidemiological elucidation of Japanese, American, and European gastric and colorectal carcinogenesis by integrated analysis of functional RNA and clinical application and cancer prevention

    • Principal Investigator
      YAMAMOTO Hiroyuki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cancer epidemiology and prevention
    • Research Institution
      St. Marianna University School of Medicine
      Sapporo Medical University
  •  Analysis of the abnormalities of microRNA and epigenome and the clinical application in gastroenterological cancersPrincipal Investigator

    • Principal Investigator
      SHINOMURA Yasuhisa
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Epigenomic analysis of gastrointestinal cancer stromaPrincipal Investigator

    • Principal Investigator
      SHINOMURA Yasuhisa
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

    • Principal Investigator
      IMAI Kohzoh, 中村 祐輔
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      The University of Tokyo
  •  Establishment of a treatment for advanced hepatocellular carcinoma using a tri-functional specific antibody

    • Principal Investigator
      SASAKI Shigeru
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Analysis and risk assessment of diffuse gastric cancer based on inflammation-induced epigenetic alterationsPrincipal Investigator

    • Principal Investigator
      SHINOMURA Yasuhisa
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  消化管間質腫瘍におけるマイクロRNA発現異常の解明Principal Investigator

    • Principal Investigator
      篠村 恭久
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Mechanism of development and progression of gastrointestinal cancer by analysis of insulirrlike growth factor system and extracelluar matrix degrading enzymes

    • Principal Investigator
      YAMAMOTO Hiroyuki
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Development of diagnostic methods of gastrointestinal cancer using integrated analysis of nuclear moleculesPrincipal Investigator

    • Principal Investigator
      SHINOMURA Yasuhisa
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Molecular mechanisms of epigenetic alterations in gastrointestinal cancer and application to diagnosis and therapy

    • Principal Investigator
      IMAI Kohzoh
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Development of therapeutic transplantation of human bone marrow mesenchymal cells into injured liver.

    • Principal Investigator
      KISO Shinichi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      OSAKA UNIVERSITY
  •  Analysis of proliferation and differentiation in the gastric epithelial cells derived from p38MAPK transgene mouse.

    • Principal Investigator
      TSUTSUI Shusaku
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  新規癌転移関連分子Mlzeの機能解析-消化器癌の転移における役割-Principal Investigator

    • Principal Investigator
      篠村 恭久
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Interaction of proinflammatory cytokines and growth factors in gastric carcinogenesisPrincipal Investigator

    • Principal Investigator
      SHINOMURA Yasuhisa
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Development of a new therapy of Chohn's disease by the regulation of Macrophage/Monocyte function

    • Principal Investigator
      KIYOHARA Tatsuya
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Role of NF-kappaB in the growth, differentiation and apoptosis of gastric epithelial cells

    • Principal Investigator
      MIYAZAKI Yoshiji
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Effect of gain-of-function mutation of c-kit on apoptosis in gastrointestinal mesenchymal cellsPrincipal Investigator

    • Principal Investigator
      SHINOMURA Yasuhisa
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Development of novel therapeutics targeting the function of intestinal cells of Cajal in gastrointestinal motility disorderPrincipal Investigator

    • Principal Investigator
      SHINOMURA Yasuhisa
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Role of PPARγ in the growth, differentiation and apoptosis of gastrointestinal epithelial cells.

    • Principal Investigator
      MIYAZAKI Yoshiji
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Research on the abnormal expressions of bcl-xL and bak in gastrointestinal cancers

    • Principal Investigator
      KANAYAMA Shuji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Role of gain-of-function mutations of c-kit gene on tumor development in gastrointestinal stromal tumor.Principal Investigator

    • Principal Investigator
      SHINOMURA Yasuhisa
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Role of EGF receptor in the growth, differentiation and apoptosis resistance of gastrointestinal epithelial cells.

    • Principal Investigator
      MIYAZAKI Yoshiji, 東本 好文
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  ヘリコバクター胃炎における胃癌発生メカニズムの解明と除菌対象群の設定

    • Principal Investigator
      金山 周次
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  トランスジェニックマウスを用いたHB-EGFの胃機能調節と発癌における役割の研究

    • Principal Investigator
      東本 好文
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  慢性萎縮性胃炎における胃粘膜細胞の増殖・分化に関わる炎症性サイトカインの役割Principal Investigator

    • Principal Investigator
      篠村 恭久
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  胃癌、胃十二指腸潰瘍の発症におけるヘリコバクター病原性因子の役割

    • Principal Investigator
      金山 周次
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  トランスジェニックマウスを用いた肝細胞増殖因子(HGF)の胃における役割の検討

    • Principal Investigator
      東本 好文
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  消化性潰瘍,胃癌の発症における宿主側免疫遺伝子とヘリコバクター細胞毒素の役割

    • Principal Investigator
      金山 周次
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  サイトカインの胃粘膜機能制御に及ぼす影響Principal Investigator

    • Principal Investigator
      篠村 恭久
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  ヒト胃粘膜上皮細胞培養系の開発

    • Principal Investigator
      金山 周次
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  The mechanism of a novel type of hyperuricemia, "myogenic hyperuricemia"

    • Principal Investigator
      KONO Norio
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Osaka University Medical School

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book Patent

  • [Book] 大腸腺腫と大腸鋸歯状病変における遺伝子異常と生活習慣の関連2014

    • Author(s)
      五十嵐央祥、能正勝彦、伊藤美樹、篠村恭久
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Book] Inflammation-related aberrant patterns of DNA methylation : detection and role in epigenetic deregulation of cancer cell transcriptome. Inflammation and Cancer. Methods and Protocols : Volume 2 : Molecular Analysis and Pathways. Methods in Molecular Biology Edited by Serguei V. New York, USA. 5122009

    • Author(s)
      Suzuki H, Toyota M, Kondo Y, Shinomura Y.
    • Publisher
      Kozlov. Humana Press
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Book] 消化管と遺伝子異常. 消化管病理標本の読み方改訂2版2008

    • Author(s)
      豊田実、今井浩三、篠村恭久, 中村眞一. (編集)
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Book] The role and clinical implication of DNA methylation in gastrointestinal cancer. Recent Advances in Gastrointestinal Carcinogenesis.2006

    • Author(s)
      Toyota M, Suzuki H, Maruyama R, Tarasawa I, Yamamoto E, Tokino T, Imai K, Shinomura Y
    • Publisher
      Edited by Bamba H and Ota S, Transworld Research Network, Kerala, India
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway.2016

    • Author(s)
      Kurihara H, Maruyama R, Ishiguro K, Kanno S, Yamamoto I, Ishigami K, Mitsuhashi K, Igarashi H, Ito M, Tanuma T, Sukawa Y, Okita K, Hasegawa T, Imai K, Yamamoto H, Shinomura Y, Nosho K.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 11 Pages: 12704-12717

    • DOI

      10.18632/oncotarget.7260

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14397, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-16K07145, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
  • [Journal Article] Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer.2016

    • Author(s)
      Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yamamoto I, Ishigami K, Igarashi H, Maruyama R, Imai K, Yamamoto H, Shinomura Y.
    • Journal Title

      World J Gastroenterol

      Volume: 22 Issue: 2 Pages: 557-566

    • DOI

      10.3748/wjg.v22.i2.557

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14397, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
  • [Journal Article] Association of microRNA-31-5p with clinical efficacy of anti-EGFR therapy in patients with metastatic colorectal cancer2015

    • Author(s)
      Igarashi H, Kurihara H, Mitsuhashi K, Ito M, Okuda H, Kanno S, Naito T, Yoshii S, Takahashi H, Kusumi T, Hasegawa T, Sukawa Y, Adachi Y, Okita K, Hirata K, Imamura Y, Baba Y, Imai K, Suzuki H, Yamamoto H, Nosho K, Shinomura Y
    • Journal Title

      Ann Surg Oncol

      Volume: 14 Issue: 8 Pages: 4264-4267

    • DOI

      10.1245/s10434-014-4264-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670371, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-26293290
  • [Journal Article] Contextual niche signals towards colorectal tumor progression by mesenchymal stem cell in the mouse xenograft model2015

    • Author(s)
      Nakagaki S, Arimura Y, Nagaishi K, Isshiki H, Nasuno M, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y
    • Journal Title

      J Gastroenterol

    • Description
      【掲載確定】 Epub ahead of print
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy2015

    • Author(s)
      Mitsuhashi K, Yamamoto I, Kurihara H, Kanno S, Ito M, Igarashi H, Ishigami K, Sukawa Y, Tachibana M, Takahashi H, Tokino T, Maruyama R, Suzuki H, Imai K, Shinomura Y, Yamamoto H, Nosho K
    • Journal Title

      ONCOTARGET

      Volume: 6 Issue: 26 Pages: 22114-22125

    • DOI

      10.18632/oncotarget.4294

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101
  • [Journal Article] Low-frequency IL23R coding variant associated with Crohn's disease susceptibility in Japanese subjects identified by personal genomics analysis2015

    • Author(s)
      Onodera K, Arimura Y, Isshiki H, Kawakami K, Nagaishi K, Yamashita K, Yamamoto E, Niinuma T, Naishiro Y, Suzuki H, Imai K, Shinomura Y
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 9 Pages: e0137801-e0137801

    • DOI

      10.1371/journal.pone.0137801

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08972, KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-26460975, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25460954, KAKENHI-PROJECT-25460955, KAKENHI-PROJECT-26640101
  • [Journal Article] 抗体治療 特集「DDSがもたらした新しい臨床の風景」2015

    • Author(s)
      佐々木茂, 篠村恭久, 今井浩三
    • Journal Title

      Drug Delivery System

      Volume: 30 Issue: 1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Clinicopathological and molecular characteristics of serrated lesions in Japanese elderly patients2015

    • Author(s)
      Nosho K, Igarashi H, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yoshii S, Mikami M, Takahashi H, Kusumi T, Hosokawa M, Sukawa Y, Adachi Y, Hasegawa T, Okita K, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y
    • Journal Title

      Digestion

      Volume: 91(1) Issue: 1 Pages: 57-63

    • DOI

      10.1159/000368820

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25293289
  • [Journal Article] Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors2015

    • Author(s)
      Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H
    • Journal Title

      Oncotarget

      Volume: 6 Issue: 30 Pages: 29975-90

    • DOI

      10.18632/oncotarget.5034

    • NAID

      130005161526

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-15K15584, KAKENHI-PROJECT-15K18431, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-25460420, KAKENHI-PROJECT-26640101
  • [Journal Article] Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis2015

    • Author(s)
      Mitsuhashi K, Nosho K, Sukawa Y, Matsunaga Y, Ito M, Kurihara H, Kanno S, Igarashi H, Naito T, Adachi Y, Tachibana M, Tanuma T, Maguchi H, Shinohara T, Hasegawa T, Imamura M, Kimura Y, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y
    • Journal Title

      Oncotarget

    • Description
      【掲載確定】 in press
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway.2015

    • Author(s)
      Ito M, Kanno S, Nosho K, Sukawa Y, Mitsuhashi K, Kurihara H, Igarashi H, Takahashi T, Tachibana M, Takahashi H, Yoshii S, Takenouchi T, Hasegawa T, Okita K, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y.
    • Journal Title

      Int J Cancer

      Volume: 137 Issue: 6 Pages: 1258-1268

    • DOI

      10.1002/ijc.29488

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K14397, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-26640101
  • [Journal Article] Role of interleukin-32 in the mechanism of chronic inflammation in IgG4-related disease and as a predictive biomarker for drug-free remission.2015

    • Author(s)
      Shimizu Y, Yamamoto M, Yajima H, Suzuki C, Naishiro Y, Takahashi H, Imai K, Shinomura Y.
    • Journal Title

      Modern Rheumatology

      Volume: 26(3) Pages: 391-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: Results from the SMART database.2014

    • Author(s)
      Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
    • Journal Title

      Mod Rheumatol

      Volume: 27 Issue: 2 Pages: 1-6

    • DOI

      10.3109/14397595.2014.950036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25861575, KAKENHI-PROJECT-15K10818, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101
  • [Journal Article] HER2 Expression and PI3K-Akt Pathway Alterations in Gastric Cancer2014

    • Author(s)
      Sukawa Y, Yamamoto H, Nosho K, Ito M, Igarashi H, Naito T, Mitsuhashi K, Matsunaga Y, Takahashi T, Mikami M, Adachi Y, Suzuki H, Shinomura Y.
    • Journal Title

      Digestion

      Volume: 89 Pages: 12-17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma2014

    • Author(s)
      Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y
    • Journal Title

      Tumour Biol

      Volume: 35 Issue: 2 Pages: 973-985

    • DOI

      10.1007/s13277-013-1131-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-24650632, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
  • [Journal Article] The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma2014

    • Author(s)
      Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y.
    • Journal Title

      Tumour Biol.

      Volume: 35 Pages: 973-985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway2014

    • Author(s)
      Nosho K, Igarashi H, Nojima M, Ito M, Maruyama R, Yoshii S, Naito T, Sukawa Y, Mikami M, Sumioka W, Yamamoto E, Kurokawa S, Adachi Y, Takahashi H, Okuda H, Kusumi T, Hosokawa M, Fujita M, Hasegawa T, Okita K, Hirata K, Suzuki H, Yamamoto H, Shinomura Y.
    • Journal Title

      Carcinogenesis

      Volume: 35 Pages: 776-783

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2014

    • Author(s)
      Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y. et al.
    • Journal Title

      J Gastroenterol

      Volume: 49 Pages: 1135-1144

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa2014

    • Author(s)
      Yamamoto H, Watanabe Y, Maehata T, Morita R, Yoshida Y, Oikawa R, Ishigooka S, Ozawa SI, Matsuo Y, Hosoya K, Yamashita M, Taniguchi H, Nosho K, Suzuki H, Yasuda H, Shinomura Y, Itoh F
    • Journal Title

      World J Gastroenterol

      Volume: 20 Pages: 3927-3937

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Journal Article] Association of microRNA-31-5p with clinical efficacy of anti-EGFR therapy in patients with metastatic colorectal cancer2014

    • Author(s)
      Igarashi H, Kurihara H, Mitsuhashi K, Ito M, Okuda H, Kanno S, Naito T, Yoshii S, Takahashi H, Kusumi T, Hasegawa T, Sukawa Y, Adachi Y, Okita K, Hirata K, Imamura Y, Baba Y, Imai K, Suzuki H, Yamamoto H, Nosho K, Shinomura Y
    • Journal Title

      Annals of Surgical Oncology

    • Description
      Epub ahead of print
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] 大規模コホートを用いた大腸癌のノンコーディングRNA発現異常と生活習慣の分子疫学的解析2014

    • Author(s)
      能正勝彦, 五十嵐央祥, 伊藤美樹, 三橋慧, 栗原弘義, 菅野伸一, 内藤崇史, 須河安恭敬, 松永康孝, 足立靖, 野島正寛, 今井浩三, 丸山玲緒, 鈴木拓, 山本博幸, 篠村恭久
    • Journal Title

      日本癌病態治療研究会誌

      Volume: 20 Issue: 1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Association of microRNA-31 with BRAF mutation, colorectal cancer survival, and serrated pathway2014

    • Author(s)
      Nosho K (他18名), Igarashi H, Ito M, Nojima M, Yamamoto H, Shinomura Y
    • Journal Title

      Carcinogenesis

      Volume: 35 Issue: 4 Pages: 776-783

    • DOI

      10.1093/carcin/bgt374

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-25670371
  • [Journal Article] Mesenchymal stem cells cancel azoxymethane-induced tumor initiation2014

    • Author(s)
      Nasuno M, Arimura Y, Nagaishi K, Isshiki H, Onodera K, Nakagaki S, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y
    • Journal Title

      Stem Cells

      Volume: 32 Issue: 4 Pages: 913-925

    • DOI

      10.1002/stem.1594

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-24650632, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-25460954, KAKENHI-PROJECT-25460955, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
  • [Journal Article] MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions2014

    • Author(s)
      Ito M, Mitsuhashi K, Igarashi H, Nosho K, Yamamoto H
    • Journal Title

      Int J Cancer

      Volume: (Epub ahead of print) Issue: 11 Pages: 2507-2515

    • DOI

      10.1002/ijc.28920

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
  • [Journal Article] HER2 expression and PI3K-Akt pathway alterations in gastric cancer2014

    • Author(s)
      Sukawa Y, Yamamoto H (他9名), Nosho K, Shinomura Y
    • Journal Title

      Digestion

      Volume: 89 Issue: 1 Pages: 12-17

    • DOI

      10.1159/000356201

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2014

    • Author(s)
      Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y
    • Journal Title

      J Gastroenterol

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Journal Article] Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer.2014

    • Author(s)
      Harada T, Yamamoto E, Yamano HO, Nojima M, Maruyama R, Kumegawa K, Ashida M, Yoshikawa K, Kimura T, Harada E, Takagi R, Tanaka Y, Aoki H, Nishizono M, Nakaoka M, Tuyada A, Niinuma T, Kai M, Shimoda K, Shinomura Y, Sugai T, Imai K, Suzuki H.
    • Journal Title

      Cancer Prev Res (Phila)

      Volume: 7(10) Issue: 10 Pages: 1002-1010

    • DOI

      10.1158/1940-6207.capr-14-0162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
  • [Journal Article] IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions2014

    • Author(s)
      Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y.
    • Journal Title

      World J Gastroenterol

      Volume: 20(29) Issue: 29 Pages: 10050-61

    • DOI

      10.3748/wjg.v20.i29.10050

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
  • [Journal Article] An updated review of gastric cancer in the next-generation sequencing era : Insights from bench to bedside and vice versa2014

    • Author(s)
      Yamamoto H (他14名), Nosho K, Shinomura Y
    • Journal Title

      World J Gastroenterol

      Volume: 20 Issue: 14 Pages: 3927-3937

    • DOI

      10.3748/wjg.v20.i14.3927

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23590928, KAKENHI-PROJECT-25460937, KAKENHI-PROJECT-25670371
  • [Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2013

    • Author(s)
      Suzuki R, Nosho K (他14名), Yamamoto H, Shinomura Y
    • Journal Title

      J Gastroenterol

      Volume: (Epub ahead of print) Issue: 7 Pages: 1135-1144

    • DOI

      10.1007/s00535-013-0861-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23791283, KAKENHI-PROJECT-25460420, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-25670371, KAKENHI-PROJECT-25830103, KAKENHI-PROJECT-25860547, KAKENHI-PROJECT-25860548
  • [Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk.2013

    • Author(s)
      Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y.
    • Journal Title

      J Gastroenterol

      Volume: [Epub ahead of print]

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2013

    • Author(s)
      Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y.
    • Journal Title

      J Gastroenterol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] Model of translational cancer research in multiple myeloma2012

    • Author(s)
      Yasui H, Ishida T, Maruyama R, Nojima M, Ikeda H, Suzuki H, Hayashi T, Shinomura Y, Imai K
    • Journal Title

      Cancer Sci

      Volume: 103 Pages: 1907-1912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] IGF-I receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers2012

    • Author(s)
      Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y
    • Journal Title

      Cancer Sci

      Volume: 103 Pages: 252-261

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer2012

    • Author(s)
      Sukawa Y, Yamamoto H (他11名), Nosho K, Shinomura Y
    • Journal Title

      World J Gastroenterol

      Volume: 18 Issue: 45 Pages: 6577-6586

    • DOI

      10.3748/wjg.v18.i45.6577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23790800
  • [Journal Article] Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer2012

    • Author(s)
      Yamamoto H, Adachi Y, Taniguchi H, Kunimoto H, Nosho K, Suzuki H, Shinomura Y
    • Journal Title

      World J Gastroenterol

      Volume: 18 Pages: 2745-2755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Aberrant DNA methylation associatedwith aggressiveness of gastrointestinal stromal tumour2012

    • Author(s)
      Okamoto Y, Sawaki A, Ito S, Nishida T, Takahashi T, Toyota M, Suzuki H, Shinomura Y, Takeuchi I, Shinjo K, An B, Ito H, Yamao K, Fujii M, Murakami H, Osada H, Kataoka H, Joh T, Sekido Y, Kondo Y
    • Journal Title

      Gut

      Volume: 61 Pages: 392-401

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] The effective molecular targeted therapies for gastroenterological tumors2012

    • Author(s)
      Nosho K, Shinomura Y.
    • Journal Title

      Medical Science Digest., Japan

      Volume: 38 Pages: 154-157

    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] Aberrant Methylation of RASGRF1 Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer.2012

    • Author(s)
      Takamaru H, Yamamoto E, Suzuki H.
    • Journal Title

      Cancer Prev Res (Phila)

      Volume: 5(10) Issue: 10 Pages: 2012-2012

    • DOI

      10.1158/1940-6207.capr-12-0056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590317, KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632
  • [Journal Article] IGF-I receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers2012

    • Author(s)
      Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y.
    • Journal Title

      Cancer Sci.

      Volume: 103 Pages: 252-261

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer.2012

    • Author(s)
      Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M,Mikami M, Matsuno T, Hasegawa T, Hirata K, Imai K, Shinomura Y
    • Journal Title

      World J Gastroenterol

      Volume: 18 Pages: 6577-6586

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype2012

    • Author(s)
      Yamamoto E, Suzuki H, Yamano HO, Maruyama R, Nojima M, Kamimae S, Sawada T, Ashida M, Yoshikawa K, Kimura T, Takagi R, Harada T, Suzuki R, Sato A, Kai M, Sasaki Y, Tokino T, Sugai T, Imai K, Shinomura Y, Toyota M
    • Journal Title

      Am J Pathol

      Volume: 181 Pages: 1847-1861

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors2012

    • Author(s)
      Niinuma T, Suzuki H, Nojima M, Nosho K, Yamamoto H, Takamaru H, Yamamoto E, Maruyama R, Nobuoka T, Miyazaki Y, Nishida T, Bamba T, Kanda T, Ajioka Y, Taguchi T, Okahara S, Takahashi H, Nishida Y, Hosokawa M, Hasegawa T, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y
    • Journal Title

      Cancer Res

      Volume: 72 Pages: 1126-1136

    • NAID

      10031131121

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma2012

    • Author(s)
      Kimura T, Yamamoto E, Yamano HO, Suzuki H, Kamimae S, Nojima M, SawadaT, Ashida M, Yoshikawa K, Takagi R, Kato R, Harada T, Suzuki R, Maruyama R, Kai M, Imai K, Shinomura Y, Sugai T, Toyota M
    • Journal Title

      Am J Gastroenterol

      Volume: 107 Pages: 460-469

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer.2012

    • Author(s)
      Yamamoto H, Adachi Y, Taniguchi H, Kunimoto H, Nosho K, Suzuki H, Shinomura Y.
    • Journal Title

      World J Gastroenterol.

      Volume: 18 Pages: 2745-2755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer2012

    • Author(s)
      Takamaru H, Yamamoto E, Suzuki H, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Suzuki R, Yamamoto H, Kai M, Tokino T, Sugai T, Imai K, Toyota M, Shinomura Y.
    • Journal Title

      Cancer Prev Res

      Volume: 5 Pages: 1203-1212

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors2012

    • Author(s)
      Takeshi Niinuma
    • Journal Title

      Cancer research

      Volume: 72 Issue: 5 Pages: 1126-36

    • DOI

      10.1158/0008-5472.can-11-1803

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632
  • [Journal Article] Emerging links between epigenetic alterations and dysregulation of noncoding RNAs in cancer.2012

    • Author(s)
      Maruyama R, Suzuki H, Yamamoto E, Imai K, Shinomura Y.
    • Journal Title

      Tumour Biol.

      Volume: 33 Pages: 275-285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] Model of translational cancer research in multiple myeloma.2012

    • Author(s)
      Yasui H, Ishida T, Maruyama R, Nojima M, Ikeda H, Suzuki H, Hayashi T, Shinomura Y, Imai K.
    • Journal Title

      Cancer Sci

      Volume: 103 Pages: 1207-1212

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors2012

    • Author(s)
      Niinuma T, Suzuki H, Nojima M, Nosho K, Yamamoto H, Takamaru H, Yamamoto E, Maruyama R, Nobuoka T, Miyazaki Y, Nishida T, Bamba T, Kanda T, Ajioka Y, Taguchi T, Okahara S, Takahashi H, Nishida Y, Hosokawa M, Hasegawa T, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y.
    • Journal Title

      Cancer Res.

      Volume: 72 Pages: 1126-1136

    • NAID

      10031131121

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] Alterations in the HER2-PI3K-Akt pathway in gastric cancer2012

    • Author(s)
      Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M, Mikami M, Matuno T, Hasegawa T, Hirata K, Imai K, Shinomura Y.
    • Journal Title

      World J Gastroenterol

      Volume: 18 Pages: 6577-6586

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer2012

    • Author(s)
      Yamamoto H, Adachi Y, Taniguchi H, Kunimoto H, Nosho K, Suzuki H, Shinomura Y
    • Journal Title

      World J Gastroenterol

      Volume: 18 Issue: 22 Pages: 2745-2755

    • DOI

      10.3748/wjg.v18.i22.2745

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200
  • [Journal Article] Genome-wide analysis of DNA methylation identifies novel cancer-related genes in hepatocellular carcinoma2012

    • Author(s)
      Shitani M, Sasaki S, Akutsu N, Takagi H, Suzuki H, Nojima M, Yamamoto H, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y
    • Journal Title

      Tumour Biol

      Volume: 33 Pages: 1307-1317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Emerging links between epigenetic alterations and dysregulation of noncoding RNAs in cancer2012

    • Author(s)
      Maruyama R, Suzuki H, Yamamoto E, Imai K, Shinomura Y
    • Journal Title

      Tumour Biol

      Volume: 33 Pages: 277-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors2011

    • Author(s)
      Kamimae S, Yamamoto E, Yamano HO, Nojima M, Suzuki H, Ashida M, Hatahira T, Sato A, Kimura T, Yoshikawa K, Harada T, Hayashi S, Takamaru H, Maruyama R, Kai M, Nishiwaki M, Sugai T, Sasaki Y, Tokino T, Shinomura Y, Imai K, Toyota M
    • Journal Title

      Cancer Prev Res

      Volume: 4 Pages: 674-683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis2011

    • Author(s)
      Hizaki K, Yamamoto H, Taniguchi H, Adachi Y, Nakazawa M, Tanuma T, Kato N, Sukawa Y, Sanchez JV, Suzuki H, Sasaki S, Imai K, Shinomura Y
    • Journal Title

      Mod Pathol

      Volume: 24 Pages: 876-884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Interferon-α/βand anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo2011

    • Author(s)
      Sasaki S, Ishida T, Toyota M, Ota A, Suzuki H, Takaoka A, Yasui H, Yamamoto H, Takagi H, Maeda M, Seito T, Tsujisaki M, Shinomura Y, Imai K
    • Journal Title

      PLoS One

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590853
  • [Journal Article] Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis.2011

    • Author(s)
      Hizaki K, Yamamoto H, Taniguchi H, Adachi Y, Nakazawa M, Tanuma T, Kato N, Sukawa Y, Sanchez JV, Suzuki H, Sasaki S, Imai K, Shinomura Y.
    • Journal Title

      Mod Pathol

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] The efficacy of IGF-I receptor monoclonal antibody against human gastrointestinal carcinomas is independent of k-ras mutation status2011

    • Author(s)
      Ii M, Li H, Adachi Y, Yamamoto H, Ohashi H, Taniguchi H, Arimura Y, Carbone DP, Imai K, Shinomura Y
    • Journal Title

      Clin Cancer Res

      Volume: 17 Pages: 5048-5059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Co-expression of laminin β3 and γ2 chains and epigenetic inactivation of laminin α3 chain in gastric cancer2011

    • Author(s)
      Ii M, Yamamoto H, Taniguchi H, Adachi Y, Nakazawa M, Ohashi H, Tanuma T, Sukawa Y, Suzuki H, Sasaki S, Imai K, Shinomura Y
    • Journal Title

      Int J Oncol

      Volume: 39 Pages: 593-599

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Genome-wide profiling of chromatin signatures reveals epigenetic regulation of microRNA genes in colorectal cancer2011

    • Author(s)
      Suzuki H, Takatsuka S, Akashi H, Yamamoto E, Nojima M, Maruyama R, Kai M, Yamano HO, Sasaki Y, Tokino T, Shinomura Y, Imai K, Toyota M
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 5646-5658

    • NAID

      130004436468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo2011

    • Author(s)
      Sasaki S, Ishida T, Toyota M, Ota A, Suzuki H, Takaoka A, Yasui H, Yamamoto H, Takagi H, Maeda M, Seito T, Tsujisaki M, Shinomura Y, Imai K
    • Journal Title

      PLoS One

      Volume: 6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer.2011

    • Author(s)
      Yamamoto E, Suzuki H, Takamaru H, Yamamoto H, Toyota M, Shinomura Y.
    • Journal Title

      Digestion 83

      Pages: 241-249

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line, MKN452011

    • Author(s)
      Li H, Adachi Y, Yamamoto H, Min Y, Ohashi H, Ii M, Arimura Y, Endo T, Lee CT, Carbone DP, Imai K, Shinomura Y
    • Journal Title

      Cancer

      Volume: 117 Pages: 3135-3147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Journal Article] Profiling of chromatin signatures reveals epigenetic regulation of microRNA genes in colorectal cancer2011

    • Author(s)
      Suzuki H, Takatsuka S, Akashi H, Yamamoto E, Nojima M, Maruyama R, Kai M, Yamano H, Sasaki Y, Tokino T, Shinomura Y, Imai K, Toyota M.
    • Journal Title

      Cancer Res.

      Volume: 71 Pages: 5646-58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Journal Article] A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers.2010

    • Author(s)
      Adachi Y, Yamamoto H, Ohashi H, Endo T, Carbone DP, Imai K, Shinomura Y.
    • Journal Title

      World J Gastroenterol 16

      Pages: 5779-5789

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010

    • Author(s)
      Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JP, Shinomura Y, Tokino T, Toyota M.
    • Journal Title

      Carcinogenesis 31

      Pages: 342-349

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect.2010

    • Author(s)
      Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano HO, Yoshikawa K, Kimura T, Kudo T, Harada E, Sugai T, Takamaru H, Niinuma T, Maruyama R, Yamamoto H, Tokino T, Imai K, Toyota M, Shinomura Y.
    • Journal Title

      Carcinogenesis 31

      Pages: 2066-2073

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] A novel correlation between LINE-1 hypomethylation and the malignancy of gastrointestinal stromal tumors.2010

    • Author(s)
      Igarashi S, Suzuki H, Niinuma T, Shimizu H, Nojima M, Iwaki H, Nobuoka T, Nishida T, Miyazaki Y, Takamaru H, Yamamoto E, Yamamoto H, Tokino T, Hasegawa T, Hirata K, Imai K, Toyota M, Shinomura Y.
    • Journal Title

      Clin Cancer Res 16

      Pages: 5114-5123

    • NAID

      130004927691

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers.2010

    • Author(s)
      Wang Y, Adachi Y, Imsumran A, Yamamoto H, Piao W, Li H, Ii M, Arimura Y, Park MY, Kim D, Lee CT, Carbone DP, Imai K, Shinomura Y.
    • Journal Title

      J Gastroenterol 45

      Pages: 159-170

    • NAID

      10027214385

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] IGFBP7 is p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010

    • Author(s)
      Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JPJ, Shinomura Y, Tokino T, Toyota M
    • Journal Title

      Carcinogenesis 31

      Pages: 342-349

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Epigenetic inactivation of the circadian clock gene BMAL1 in hematological malignancies.2009

    • Author(s)
      Taniguchi H, Fernandez AF, Setien F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M
    • Journal Title

      Cancer Res 69

      Pages: 8447-8454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity.2009

    • Author(s)
      Yabana T, Arimura Y, Tanaka H, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Adachi Y, Sasaki Y, Isobe M, Fujimiya M, Imai K, Shinomura Y.
    • Journal Title

      J Pathol 218

      Pages: 350-359

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Integrated analysis of genetic and epigenetic alterations in cancer.2009

    • Author(s)
      Toyota M, Suzuki H, Yamamoto E, Yamano H, Imai K, Shinomura Y
    • Journal Title

      Epigenomics 1

      Pages: 291-299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.2009

    • Author(s)
      Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Adachi Y, Imai K, Shinomura Y.
    • Journal Title

      World J Gastroenterol 15

      Pages: 3865-3873

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma.2009

    • Author(s)
      Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
    • Journal Title

      Clin Cancer Res 15

      Pages: 4356-4364

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Cancer Epigenomics : Implications of DNA methylation in personalized therapy.2009

    • Author(s)
      Toyota M, Suzuki H, Yamashita T, Hirata K, Shinomura Y, Tokino T, Imai K
    • Journal Title

      Cancer Sci 100

      Pages: 787-791

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma.2009

    • Author(s)
      Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y.
    • Journal Title

      Clin Cancer Res 15

      Pages: 4356-4364

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.2009

    • Author(s)
      Taniguchi H, Fernandez AF, Setien F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M.
    • Journal Title

      Cancer Res 69

      Pages: 8447-8454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen.2009

    • Author(s)
      Yamaoka S, Yamamoto H, Nosho K, Taniguchi H, Adachi Y, Sasaki S, Arimura Y, Imai K, Shinomura Y.
    • Journal Title

      World J Gastroenterol 15

      Pages: 5579-5585

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.2009

    • Author(s)
      Asano K, Matsushita T, Umeno J, Hosono N, Takahashi A, Kawaguchi T, Matsumoto T, Matsui T, Kakuta Y, Kinouchi Y, Shimosegawa T, Hosokawa M, Arimura Y, Shinomura Y, Kiyohara Y, Tsunoda T, Kamatani N, Iida M, Nakamura Y, Kubo M.
    • Journal Title

      Nat Genet 41

      Pages: 1325-1329

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Cancer epigenomics : implications of DNA methylation in personalized cancer therapy.2009

    • Author(s)
      Toyota M, Suzuki H, Yamashita T, Hirata K, Imai K, Tokino T, Shinomura Y.
    • Journal Title

      Cancer Sci 100

      Pages: 787-791

    • NAID

      10025145027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] p53 family members regulate the expression of the apolipoprotein D gene.2009

    • Author(s)
      Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
    • Journal Title

      J Biol Chem 284

      Pages: 872-883

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.2008

    • Author(s)
      Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB.
    • Journal Title

      Cancer Res 68

      Pages: 2570-2575

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008

    • Author(s)
      Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M.
    • Journal Title

      Pharmacogenomics 9

      Pages: 1917-1928

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008

    • Author(s)
      Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y.
    • Journal Title

      J Gastroenterol 43

      Pages: 378-389

    • NAID

      10021268741

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008

    • Author(s)
      Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka Y, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Carcinogenesis 29

      Pages: 1312-1318

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis.2008

    • Author(s)
      Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 17

      Pages: 2555-2564

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008

    • Author(s)
      Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T.
    • Journal Title

      Cancer Sci 99

      Pages: 958-966

    • NAID

      10024006089

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.2008

    • Author(s)
      Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T.
    • Journal Title

      Cancer Res 68

      Pages: 4123-4132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008

    • Author(s)
      Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
    • Journal Title

      J. Gastroenterol 43

      Pages: 378-389

    • NAID

      10021268741

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008

    • Author(s)
      Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M
    • Journal Title

      Pharmacogenomics 9

      Pages: 1917-1928

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008

    • Author(s)
      Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T
    • Journal Title

      Cancer Sci 99

      Pages: 958-966

    • NAID

      10024006089

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Identification of flotillin-2, a major protein on lipid rafths, as a novel target of the p53 family members.2008

    • Author(s)
      Sasaki Y, Ohshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
    • Journal Title

      Mol Cancer Res 6

      Pages: 395-406

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] A requirement for DICER to maintain full promoter CpG Island hypermethylation in human cancer cells.2008

    • Author(s)
      Ting A, Suzuki H, Cope L, Schuebel K, Lee B, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
    • Journal Title

      Cancer Res 68

      Pages: 2570-2575

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008

    • Author(s)
      Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T.
    • Journal Title

      Carcinogenesis 29

      Pages: 1312-1318

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008

    • Author(s)
      Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Cancer Res 68

      Pages: 4123-4132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma.2008

    • Author(s)
      Nosho K, Yamamoto H, Takahashi T, Mikami M, Hizaki K, Maehata T, Taniguchi H, Yamaoka S, Adachi Y, Itoh F, Imai K, Shinomura Y.
    • Journal Title

      Hum Pathol 39

      Pages: 767-775

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] The hsitone deacetylase inhibitor FK288 enhances adenovirus-mediated p53 family gene therapy in cancer models.2008

    • Author(s)
      Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
    • Journal Title

      Mol Cancer Ther 7

      Pages: 779-787

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers.2008

    • Author(s)
      Oki M, Yamamoto H, Taniguchi H, Adachi Y, Imai K, Shinomura Y.
    • Journal Title

      World J Gastroenterol 14

      Pages: 5650-5656

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.2008

    • Author(s)
      Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T
    • Journal Title

      British J Cancer 98

      Pages: 1147-1156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] DNA hypermethylation contributes incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.2008

    • Author(s)
      Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
    • Journal Title

      Gastroenterol 135

      Pages: 142-151

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in helicobactor pylori-related enlarged fold gastritis.2008

    • Author(s)
      Yamamoto E, Toyota M, Suzuki H, Kondo Y, Imai K, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 17

      Pages: 2555-2564

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007

    • Author(s)
      Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Cancer Sci 98

      Pages: 88-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007

    • Author(s)
      Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
    • Journal Title

      Oncogene 26

      Pages: 4699-4713

    • NAID

      130004927598

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.2007

    • Author(s)
      Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y
    • Journal Title

      Carcinogenesis 28

      Pages: 2459-2466

    • NAID

      130004436413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer.2007

    • Author(s)
      Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Itoh F, Tokino T
    • Journal Title

      Clin Cancer Res 13

      Pages: 4786-4794

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and an association with Epstein-Barr virus.2006

    • Author(s)
      Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T
    • Journal Title

      Cancer 106

      Pages: 1467-1479

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Comparative genome analysis identified the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006

    • Author(s)
      Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Cancer Res 66

      Pages: 4574-4583

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Journal Article] Enhanced expression of suppressor of cytokine signalling-1 in the liver of chronic hepatitis C : possible involvement in resistance to interferon therapy.2005

    • Author(s)
      Imanaka K, Tamura S(2番目), Kiso S(5番目), Shinomura Y(10番目)他6名
    • Journal Title

      J Viral Hepat. 12(2)

      Pages: 130-138

    • Data Source
      KAKENHI-PROJECT-16590593
  • [Journal Article] Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease.2005

    • Author(s)
      Yamamoto K, Tamura S (11番目), Shinomura Y(14番目)(他11名)
    • Journal Title

      Gut 54(6)

      Pages: 742-744

    • Data Source
      KAKENHI-PROJECT-16590593
  • [Journal Article] Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease.2005

    • Author(s)
      Yamamoto K, Tamura S (11番目), Shinomura Y(14番目)(他11名).
    • Journal Title

      Gut 54.6

      Pages: 742-744

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590593
  • [Journal Article] Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells2005

    • Author(s)
      Osamu Kishida, Yasuhisa Shinomura(11番目)(他9名)
    • Journal Title

      Cancer Chemotherapy and Pharmacology 55(4)

      Pages: 393-403

    • Data Source
      KAKENHI-PROJECT-16590593
  • [Journal Article] Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease.2005

    • Author(s)
      Yamamoto K, Tamura S, Shinomura Y, et al.
    • Journal Title

      Gut 54(6)

      Pages: 742-744

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590593
  • [Journal Article] An enhanced expression of suppressor of cytokine signaling-1 in the liver of chronic hepatitis C : a possible involvement in resistance to interferon therapy.2005

    • Author(s)
      Imanaka K, Tamura S, Fukui K, Ito N, Kiso S, Imai Y, Naka T, Kishimoto T, Kawata S, Shinomura Y.
    • Journal Title

      J Viral Hepat. 12(2)

      Pages: 130-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells2005

    • Author(s)
      Osamu Kishida, Yasuhisa Shinomura, et al.
    • Journal Title

      Cancer Chemotherapy and Pharmacology 55(4)

      Pages: 393-403

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590593
  • [Journal Article] Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells2005

    • Author(s)
      Osamu Kishida, Yasuhisa Shinomura(11番目) (他9名)
    • Journal Title

      Cancer Chemotherapy and Pharmacology 55.4

      Pages: 393-403

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590593
  • [Journal Article] Gefitinib (‘Iressa', ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.2005

    • Author(s)
      Kishida O, Miyazaki Y, Murayama Y, Ogasa M, Miyazaki T, Yamamoto T, Watabe K, Tsutsui S, Kiyohara T, Shimomura I, Shinomura Y.
    • Journal Title

      Cancer Chemoth.Pharm. 55(4)

      Pages: 393-403

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Changes in gene expression associated with the loss of the interstitial cells of Cajal in the gastric fundus of W/W(V) mice.2004

    • Author(s)
      Shinomura Y.
    • Journal Title

      J Gastroenterol. 39(3)

      Pages: 304-305

    • NAID

      10012843131

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells.2004

    • Author(s)
      Murayama Y, Shinomura Y(13番目)他11名
    • Journal Title

      J Cell Sci. 117

      Pages: 3379-3388

    • Data Source
      KAKENHI-PROJECT-16590593
  • [Journal Article] CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells.2004

    • Author(s)
      Murayama Y, Miyagawa J, Oritani K, Yoshida H, Yamamoto K, Kishida O, Miyazaki T, Tsutsui S, Kiyohara T, Miyazaki Y, Higashiyama S, Matsuzawa Y, Shinomura Y
    • Journal Title

      J Cell Sci. 117(Pt 15)

      Pages: 3379-3388

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Distinct roles for the SgIGSF adhesion molecule and c-kit receptor tyrosine kinase in the interaction between mast cells and the mesentery.2004

    • Author(s)
      Watabe K, Ito A, Koma Y, Wakayama T, Iseki S, Shinomura Y, Kitamura Y.
    • Journal Title

      Biochem Biophys Res Commun. 324(2)

      Pages: 782-788

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Basic Fibroblast Growth Factor Promotes the Trans-differentiation of Mouse Bone Marrow Cells into Hepatic Lineage Cells via Multiple Liver-enriched Transcription Factors.2004

    • Author(s)
      Saji Y, Tamura S, Yoshida Y, Kiso S, Saeki Iizuka A, Matsumoto H, Kawasaki T, Kamada Y, Matsuzawa Y, Shinomura Y.
    • Journal Title

      J.Hepatol. 41(4)

      Pages: 545-550

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha.2004

    • Author(s)
      Ohashi A, Kinoshita K, Isozaki K, Nishida T, Shinomura Y, Kitamura Y, Hirota S.
    • Journal Title

      Int J Cancer. 111(3)

      Pages: 317-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumors from neurofibromatosis type 1 patients.2004

    • Author(s)
      Kinoshita K, Hirota S, Isozaki K, Ohashi A, Nishida T, Kitamura Y, Shinomura Y, Matsuzawa Y
    • Journal Title

      J Pathol. 202(1)

      Pages: 80-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Changes in gene expression associated with the loss of the interstitial cells of Cajal in the gastric fundus of W/W(V) mice2004

    • Author(s)
      Shinomura Y
    • Journal Title

      J Gastroenterol 39(3)

      Pages: 304-305

    • NAID

      10012843131

    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Changes in gene expression associated with the loss of the interstitial cells of Cajal in the gastric fundus of W/W(V) mice.2004

    • Author(s)
      Shinomura Y.
    • Journal Title

      J.Gastroenterol. 39(3)

      Pages: 304-305

    • NAID

      10012843131

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Helicobacter pylori-induced enlarged-fold gastritis is associated with increased mutagenicity of gastric juice, increased oxidative DNA damage, and an increased risk of gastric carcinoma.2003

    • Author(s)
      Nishibayashi H, Kanayama S, Kiyohara T, Yamamoto K, Miyazaki Y, Yasunaga Y, Shinomura Y, Takeshita T, Takeuchi T, Morimoto K, Matsuzawa Y
    • Journal Title

      J Gastroenterol Hepatol. 18(12)

      Pages: 1384-1391

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin.2003

    • Author(s)
      Kamada Y, Tamura S, Kiso S, Matsumoto H, Saji Y, Yoshida Y, Fukui K, Maeda N, Nishizawa H, Nagaretani H, Okamoto Y, Kihara S, Miyagawa J, Shinomura Y, Funahashi T, Matsuzawa Y
    • Journal Title

      Gastroenterology. 125(6)

      Pages: 1796-1807

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] c-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors.2003

    • Author(s)
      Kinoshita K, Isozaki K, Hirota S, Nishida T, Chen H, Nakahara M, Nagasawa Y, Ohashi A, Shinomura Y, Kitamura Y, Matsuzawa Y
    • Journal Title

      J Gastroenterol Hepatol. 18(2)

      Pages: 147-151

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Gain-of-function mutations of platelet-derived growth factor receptor gene in gastrointestinal stromal tumors.2003

    • Author(s)
      Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, Kitamura Y
    • Journal Title

      Gastroenterology. 125(3)

      Pages: 660-667

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Gastrin activates nuclear factor kappaB (NFkappaB) through a protein kinase C dependent pathway involving NFkappaB inducing kinase, inhibitor kappaB (IkappaB) kinase, and tumor necrosis factor receptor associated factor 6 (TRAF6) in MKN-28 cells transfected with gastrin receptor.2003

    • Author(s)
      Ogasa M, Miyazaki Y, Hiraoka S, Kitamura S, Nagasawa Y, Kishida O, Miyazaki T, Kiyohara T, Shinomura Y, Matsuzawa Y
    • Journal Title

      Gut. 52(6)

      Pages: 813-819

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumors.2003

    • Author(s)
      Kinoshita K, Isozaki K, Tsutsui S, Kitamura S, Hiraoka S, Watabe K, Nakahara M, Nagasawa Y, Kiyohara T, Miyazaki Y, Hirota S, Nishida T, Shinomura Y, Matsuzawa Y
    • Journal Title

      Eur J Gastroenterol Hepatol. 15(11)

      Pages: 1189-1193

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors.2003

    • Author(s)
      Chen H, Isozaki K, Kinoshita K, Ohashi A, Shinomura Y, Matsuzawa Y, Kitamura Y, Hirota S
    • Journal Title

      Int J Cancer. 105(1)

      Pages: 130-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Dose-dependent and time-limited proliferation of cultured murine interstitial cells of Cajal in response to stem cell factor.2002

    • Author(s)
      Nakahara M, Isozaki K, Vanderwinden JM, Shinomura Y, Kitamura Y, Hirota S, Matsuzawa Y
    • Journal Title

      Life Sci. 70(20)

      Pages: 2367-2376

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumors.2002

    • Author(s)
      Chen H, Hirota S, Isozaki K, Sun H, Ohashi A, Kinoshita K, O'Brien P, Kapusta L, Dardick I, Obayashi T, Okazaki T, Shinomura Y, Matsuzawa Y, Kitamura Y
    • Journal Title

      Gut. 51(6)

      Pages: 793-796

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene.2002

    • Author(s)
      Hirota S, Nishida T, Isozaki K, Taniguchi M, Nishikawa K, Ohashi A, Takabayashi A, Obayashi T, Okuno T, Kinoshita K, Chen H, Shinomura Y, Kitamura Y.
    • Journal Title

      Gastroenterology 122(5)

      Pages: 1493-1499

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Significance of the association between heparin-binding epidermal growth factor-like growth factor and CD9 in human gastric cancer.2002

    • Author(s)
      Murayama Y, Miyagawa J, Shinomura Y, Kanayama S, Isozaki K, Yamamori K, Mizuno H, Ishiguro S, Kiyohara T, Miyazaki Y, Taniguchi N, Higashiyama S, Matsuzawa Y
    • Journal Title

      Int.J.Cancer 98(4)

      Pages: 505-513

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Epidermal growth factor inhibits the growth of TE8 esophageal cancer cells through the activation of STAT1.2002

    • Author(s)
      Ichiba M, Miyazaki Y, Kitamura S, Kiyohara T, Shinomura Y, Matsuzawa Y
    • Journal Title

      J Gastroenterol. 37(7)

      Pages: 498-503

    • NAID

      50000581934

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Deficiency of KIT positive cells in the colon of patients with diabetes mellitus.2002

    • Author(s)
      Nakahara M, Isozaki K, Hirota S, Vanderwinden JM, Takakura R, Kinoshita K, Miyagawa J, Chen H, Miyazaki Y, Kiyohara T, Shinomura Y, Matsuzawa Y
    • Journal Title

      J.Gastroenterol.Hepatol. 17(6)

      Pages: 666-670

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Enhanced macrophage responsiveness to lipopolysaccharide and CD40 stimulation in a murine model of inflammatory bowel disease : IL-10-deficient mice.2002

    • Author(s)
      Takakura R, Kiyohara T, Murayama Y, Miyazaki Y, Miyoshi Y, Shinomura Y, Matsuzawa Y
    • Journal Title

      Inflamm Res. 51(8)

      Pages: 409-415

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370181
  • [Journal Article] Epigenetic inactivation of interferon regulatory factor genes in gastric cancer.

    • Author(s)
      Yamashita M, Toyota M, Suzuki H, Nojima M, Yamamoto E, Kamimae S, Watanabe Y, Kai M, Akashi H, Maruyama R, Sasaki Y, Yamano H, Sugai T, Shinomura Y, Imai K, Tokino T, Itoh F
    • Journal Title

      Cancer Sci (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Patent] 大腸癌を治療および/または診断するための組成物ならびにその利用2013

    • Inventor(s)
      篠村 恭久, 能正勝彦, 山本博幸, 鈴木拓
    • Industrial Property Rights Holder
      北海道公立大学法人 札幌医科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-06-14
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Patent] 腸癌を治療および/または診断するための組成物ならびにその利用2013

    • Inventor(s)
      篠村 恭久, 能正勝彦, 山本博幸, 鈴木拓
    • Industrial Property Rights Holder
      北海道公立大学法人 札幌医科大学
    • Industrial Property Number
      2013-126021
    • Filing Date
      2013-06-14
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Patent] 癌の検出方法および検出用キット、ならびに癌治療剤.2008

    • Inventor(s)
      鈴木 拓, 豊田 実, 篠村恭久, 他2名
    • Industrial Property Rights Holder
      札幌医科大学
    • Industrial Property Number
      2008-121671
    • Filing Date
      2008-05-07
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Patent] 胃粘膜洗浄液を利用した疾患関連マーカー検出法2006

    • Inventor(s)
      豊田実, 篠村恭久, 他
    • Industrial Property Rights Holder
      北海道聖マリアンヌ医科大学
    • Industrial Property Number
      2006-134878
    • Filing Date
      2006-05-15
    • Data Source
      KAKENHI-PROJECT-18390221
  • [Presentation] 大腸腫瘍の発育進展におけるFusobacterium属の役割とマイクロサテライト不安定性との関連2017

    • Author(s)
      能正勝彦、篠村恭久
    • Organizer
      第3回Gut microbiota研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08954
  • [Presentation] A combination of the anti-fibroblast growth factor receptor 1 monoclonal antibody and interferon-a/b supresses human hepatic cancer cells in vitro and in vivo2014

    • Author(s)
      Kato Y, Hiromi H, Tujisaki M, Matsune T, Sasaki S, Hinoda Y, Shinomura Y, Imai K
    • Organizer
      41 Congress of the International Society of Oncology and Biomarkers
    • Place of Presentation
      Barcelona, Spain
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Presentation] 高齢者の大腸鋸歯状病変における臨床病理学的特徴と分子異常の検討2014

    • Author(s)
      能正勝彦,五十嵐央祥,伊藤美樹,内藤崇史,吉井新二,須河恭敬,三上雅史,高橋宏明,久須美貴哉,細川正夫,奥田博介,藤田昌弘,青木敬則,山本英一郎,足立 靖,沖田憲司,平田公一,鈴木 拓,山本博幸,篠村恭久
    • Organizer
      第10回日本消化管学会総会学術集会
    • Place of Presentation
      福島ビューホテル(福島市)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] 表在型食道胃接合部癌における分子生物学的異常の解析2014

    • Author(s)
      伊藤美樹,能正勝彦,五十嵐央祥,内藤崇史,三橋 慧,田沼徳真,山本佳子,高橋宏明,細川正夫,山本博幸,篠村恭久
    • Organizer
      第10回日本消化管学会総会学術集会
    • Place of Presentation
      福島ビューホテル(福島市)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] p53 family network and tumor suppression2014

    • Author(s)
      Sasaki Y, Tamura, M, Takeda K, Idogawa M, Maruyama R, Suzuki H, Shinomura Y, Tokino T
    • Organizer
      The 3rd International Symposium on Genetic Regulation and Targeted Therapy of Cancer and 5th Symposium of A3 Foresight Program
    • Place of Presentation
      Zhangjiajie, China
    • Year and Date
      2014-06-13
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Presentation] Association between EBV infection and HER2 expression in gastric cancer2013

    • Author(s)
      Mitsuhashi K, Sukawa Y, Nakazawa M, Naito T, Ito M, Igarashi H, Kunimoto H, Nosho K, Adachi Y, Yamamoto H, Takada K, Shinomura Y
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orange County Convention Center, Orlando, USA
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] 大腸鋸歯状病変におけるmicroRNA-31の役割2013

    • Author(s)
      能正勝彦,五十嵐央祥,伊藤美樹,内藤崇史,三橋 慧,須河恭敬,丸山玲緒,山本英一郎,荻野周史,鈴木 拓,今井浩三,山本博幸,篠村恭久
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] 大腸癌の新規バイオマーカー探索を目指したEGFR下流シグナルを制御するマイクロRNAの検討2013

    • Author(s)
      能正勝彦,五十嵐央祥,伊藤美樹,内藤崇史,三橋 慧,野島正寛,山本英一郎,吉井新二,奥田博介,高橋宏明,久須美貴哉,細川正夫,沖田憲司,平田公一,丸山玲緒,鈴木 拓,山本博幸,篠村恭久
    • Organizer
      第79回大腸癌研究会
    • Place of Presentation
      梅田スカイビル(大阪市)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] Associations among the HER2 signal-related factors thought to be predictive factors for the effectiveness of trastuzumab therapy in gastric cancer2013

    • Author(s)
      Yamamoto H, Sukawa Y, Nakazawa M, Sumioka W, Watanabe Y, Maehata T, Morita R, Yoshida Y, Ishigooka S, Ozawa S, Matsuo Y, Hosoya K, Yamashita M, Taniguchi H, Nosho K, Suzuki H, Yasuda H, Imai K, Shinomura Y, Itoh F
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      Tokyo Bay Maihama Hotel Club & Resorts, Urayasu, Japan
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] Analysis of the molecular features of elderly colorectal cancer patients using a large Japanese cohort study and the lmportance of sessile serrated adenoma/polyp (SSA/P) as a precursor lesion2013

    • Author(s)
      Igarashi H, Nosho K, Ito M, Naito T, Mitsuhashi K, Sukawa Y, Mikami M, Yamamoto E, Nakazawa M, Sumioka W, Okuda H, Takahashi H, Kusumi T, Hosokawa M, Nojima M, Okita K, Suzuki H, Yamamoto H, Shinomura Y
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orange County Convention Center, Orlando, USA
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] 大腸鋸歯状病変におけるInsulin-like growth factor2(IGF2)differentially methylated region (DMR) 0メチル化レベルの解析―発癌機構の解明を目指して―2013

    • Author(s)
      能正勝彦,伊藤美樹,五十嵐央祥,内藤崇史,三橋 慧,須河恭敬,足立 靖,吉井新二,鈴木 拓,山本博幸,荻野周史,篠村恭久
    • Organizer
      第50回日本臨床分子医学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] microRNA-34b/c異常メチル化率測定による胃癌の異時性多発リスク予測2013

    • Author(s)
      鈴木 亮,山本英一郎,鈴木 拓,野島正寛,丸山玲緒,能正勝彦,山本博幸,山野泰穂,菅井 有,篠村恭久
    • Organizer
      第110回日本内科学会総会講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] Analysis of the insulin-like growth factor 2 (IGF2) differentially methylated region (DMR) 0 hypomethylation in carcinogenesis of colorectal serrated lesions2013

    • Author(s)
      Nosho K, Yoshii S, Baba Y, Igarashi H, Ito M, Naito T, Sukawa Y, Mikami M, Takahashi T, Nakazawa M, Sumioka W, Takahashi H, Hosokawa M, Suzuki H, Adachi Y, Yamamoto H, Imai K, Ogino S, Shinomura Y
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orange County Convention Center, Orlando, USA
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] 胃癌におけるトラスツズマブ治療の効果予測因子となりうるHER2シグナル関連分子異常の関連の解析2013

    • Author(s)
      山本博幸,須河恭敬,能正勝彦,前畑忠輝,谷口博昭,五十嵐央祥,伊藤美樹,内藤崇史,足立 靖,鈴木 拓,伊東文生,今井浩三,篠村恭久
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] 大規模コホートを用いた高齢者大腸癌と大腸鋸歯状病変の分子病理学的検討2013

    • Author(s)
      沼田泰尚,能正勝彦,五十嵐央祥,伊藤美樹,内藤崇史,三橋 慧,三上雅史,高橋大賀,吉井新二,高橋宏明,久須美貴哉,細川正夫,山本英一郎,山下健太郎,有村佳昭,青木敬則,野村昌史,山本博幸,平田公一,篠村恭久
    • Organizer
      第86回日本消化器内視鏡学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] 大腸癌におけるmicroRNA-31発現とBRAF遺伝子変異・抗EGFR抗体薬感受性との関連性2013

    • Author(s)
      五十嵐央祥,能正勝彦,伊藤美樹,野島正寛,吉井新二,丸山玲緒,内藤崇史,三橋 慧,山本英一郎,足立 靖,三上雅史,高橋宏明,奥田博介,細川正夫,沖田憲司,平田公一,鈴木 拓,山本博幸,篠村恭久
    • Organizer
      第33回日本分子腫瘍マーカー研究会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] 腸癌におけるLINE-1メチル化レベルとmicroRNA発現を標的とした診断・個別化治療への応用2013

    • Author(s)
      能正勝彦, 篠村恭久
    • Organizer
      第9回日本消化管学会総会学術集会
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] 日本人の高齢者における大腸癌および大腸鋸歯状腺腫の分子生物学的特徴2013

    • Author(s)
      三橋 慧,能正勝彦,内藤崇史,松永康孝,伊藤美樹,五十嵐央祥,須河恭敬,山本英一郎,丸山玲緒,足立 靖,鈴木 拓,山本博幸,篠村恭久
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] Analysis of the genome-wide DNA methylation level in colorectal adenoma for detecting the precursor lesion of line extreme hypomethylated colorectal cancer2013

    • Author(s)
      Nosho K, Igarashi H, Ito M, Naito T, Mitsuhashi K, Sukawa Y, Nakazawa M, Sumioka W, Yoshii S, Fujita M, Yamamoto E, Adachi Y, Baba Y, Nojima M, Maruyama R, Suzuki H, Yamamoto H, Imai K, Shinomura Y
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orange County Convention Center, Orlando, USA
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] microRNA-31は大腸癌におけるBRAF遺伝子変異・予後と関連する2013

    • Author(s)
      五十嵐央祥,能正勝彦,伊藤美樹,内藤崇史,三橋 慧,丸山玲緒,野島正寛,山本英一郎,吉井新二,足立 靖,鈴木 拓,山本博幸,篠村恭久
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] Dysregulation of noncoding RNA genes and its clinical application.2013

    • Author(s)
      Suzuki H, Yamamoto E, Shinomura Y and Imai K.
    • Organizer
      Ninth AACR-Japanese Cancer Association Joint Conference “Breakthroughs in Basic and Translational Cancer Research”
    • Place of Presentation
      the Hyatt Regency Maui, Maui, HI, USA.
    • Year and Date
      2013-02-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Presentation] 大腸鋸歯状病変の進展および分化におけるIGF-2DMR低メチル化の役割2013

    • Author(s)
      内藤崇史,能正勝彦,馬場祥史,伊藤美樹,五十嵐央祥,三橋 慧,山本英一郎,丸山玲緒,鈴木 拓,足立 靖,山本博幸,平田公一,篠村恭久
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] The relation of LINE methylation level and macroscopic type in colorectal adenoma and pT1 colorectal cancer2013

    • Author(s)
      Katsuhiko Nosho, Yasuhisa Shinomura
    • Organizer
      Ninth AACR-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] 大腸腫瘍におけるKRAS、BRAF、PIK3CA 変異と相関を示すmicroRNA の同定を目指したアレイシステムによる網羅的2013

    • Author(s)
      能正勝彦, 篠村恭久
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] 表在型食道胃接合部癌における分子生物学的異常の解析2013

    • Author(s)
      伊藤美樹,能正勝彦,五十嵐央祥,内藤崇史,三橋 慧,須河恭敬,田沼徳真,山本桂子,吉井新二,高橋宏明,細川正夫,山本博幸,篠村恭久
    • Organizer
      第45回胃病態機能研究会
    • Place of Presentation
      名古屋市立大学(名古屋市)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] 消化器癌の分子標的治療の現状と課題2013

    • Author(s)
      篠村 恭久
    • Organizer
      第21回日本消化器病関連学会週間(JDDW2013)
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] 胃癌の異時性多発リスク予測マーカーとしてのmicroRNA-34b/c異常メチル化測定2013

    • Author(s)
      鈴木 亮,山本英一郎,鈴木 拓,野島正寛,丸山玲緒,能正勝彦,山本博幸,山野泰穂,菅井 有,篠村恭久
    • Organizer
      第50回日本臨床分子医学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] 消化器癌の分子標的治療の現状と課題2013

    • Author(s)
      篠村 恭久
    • Organizer
      第21回日本消化器病関連学会集会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Data Source
      KAKENHI-PROJECT-25670371
  • [Presentation] microRNA-34b/cの異常メチル化は胃癌の異時性多発リスクに関与する2013

    • Author(s)
      鈴木 亮,篠村恭久
    • Organizer
      シンポジウム6HP除菌後の病態と対応 : 第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] microRNA-34b/c異常メチル化率測定による胃癌の異時性多発リスク予測2013

    • Author(s)
      鈴木 亮,山本英一郎,鈴木 拓,野島正寛,丸山玲緒,能正勝彦,山本博幸,山野泰穂,菅井 有,篠村恭久
    • Organizer
      第110回日本内科学会総会講演会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] Characteristics of and associations among the HER2 signal-related factors thought to be predictive factors for the effectiveness of trastuzumab therapy in gastric cancer2013

    • Author(s)
      Ito M, Sukawa Y, Nosho K, Igarashi H, Naito T, Kunimoto H, Mitsuhashi K, Nakazawa M, Sumioka W, Adachi Y, Mikami M, Kawayama M, Suzuki H, Yamamoto H, Shinomura Y
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orange County Convention Center, Orlando, USA
    • Data Source
      KAKENHI-PROJECT-23300366
  • [Presentation] 大腸癌の分子診断学における LINE-1 メチル化レベルの重要性と microRNA 発現の網羅的解析2012

    • Author(s)
      能正勝彦, 篠村恭久
    • Organizer
      JDDW2012
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.2012

    • Author(s)
      鈴木 拓,新沼 猛,野島正寛,丸山玲緒,山本英一郎,甲斐正広,能正勝彦,山本博幸,時野隆至,今井浩三,篠村恭久
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] GISTの悪性度マーカーおよび治療標的としての non-coding RNA2012

    • Author(s)
      新沼 猛,鈴木 拓,野島正寛,高丸博之,山本英一郎,能正勝彦,山本博幸,篠村恭久
    • Organizer
      第8回日本消化管学会総会学術集会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] 消化管間質腫瘍におけるmicroRNA発現プロファイル解析2012

    • Author(s)
      鈴木 拓,新沼 猛,野島正寛,山本英一郎,丸山玲緒,山本博幸,篠村恭久
    • Organizer
      第49回日本臨床分子医学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] Comprehensive analysis of the genome-wide DNA methylation and microRNA expression in gastrointestinal cancers and the identification of new biomarkers targeting those alterations2012

    • Author(s)
      能正勝彦, 篠村恭久
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] 胃癌におけるエピジェネティックな遺伝子異常の網羅的解析2012

    • Author(s)
      高丸博之、鈴木拓、山本英一郎、神前正幸、新沼猛、丸山玲緒、豊田実、篠村恭久
    • Organizer
      第8回日本消化管学会総会学術集会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Presentation] microRNA-34b/cの異常メチル化は胃癌の異時性多発リスクに関与する2012

    • Author(s)
      鈴木亮,山本英一郎,鈴木拓,野島正寛,丸山玲緒,能正勝彦,山本博幸,甲斐正広,山野泰穂,菅井有,今井浩三,篠村恭久
    • Organizer
      第32回日本分子腫瘍マーカー研究会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Presentation] 腸癌のグローバル DNA メチル化、microRNA 異常発現の解析とそれらを標的とした新規バイオマーカーの探索と大腸発癌の検討2012

    • Author(s)
      能正勝彦, 篠村恭久
    • Organizer
      第 23 回日本消化器癌発生学会
    • Place of Presentation
      鳴門
    • Data Source
      KAKENHI-PROJECT-23390200
  • [Presentation] GISTの悪性度マーカーおよび治療標的としてのnon-coding RNA2012

    • Author(s)
      新沼猛,鈴木拓,野島正寛,高丸博之,山本英一郎,能正勝彦,山本博幸,篠村恭久
    • Organizer
      第8回日本消化管学会総会学術集会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Presentation] 胃癌におけるエピジェネティックな遺伝子異常の網羅的解析2011

    • Author(s)
      高丸博之、鈴木拓、山本英一郎、丸山玲緒、神前正幸、新沼猛、青木由佳、澤田武、豊田実、篠村恭久
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Presentation] 消化管間質腫瘍におけるmicroRNA発現プロファイル解析2011

    • Author(s)
      新沼猛、鈴木 拓、野島正寛、高丸博之、能正勝彦、山本博幸、豊田実、篠村恭久
    • Organizer
      第19回日本消化器関連学会週間
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Presentation] 消化管間質腫瘍におけるmicroRNA発現プロファイル解析2011

    • Author(s)
      新沼猛,鈴木拓,野島正寛,高丸博之,能正勝彦,山本博幸,豊田実,篠村恭久
    • Organizer
      第53回日本消化器病学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Presentation] 胃癌におけるエピジェジェティックな遺伝子異常の網羅的解析2011

    • Author(s)
      高丸博之,鈴木拓,山本英一郎,丸山玲緒,神前正幸,新沼猛,青木由佳,澤田武,豊田実,篠村恭久
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Presentation] 胃癌におけるゲノムワイドな低メチル化と染色体不安定性2011

    • Author(s)
      鈴木亮,山本英一郎,鈴木拓,丸山玲緒,山野泰穂,今井浩三,豊田実,篠村恭久
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Presentation] DNAメチル化異常の網羅的な解析による新規胃癌関連遺伝子の検索2011

    • Author(s)
      高丸博之,鈴木拓,山本英一郎,新沼猛,山本博幸,有村佳昭,豊田実,篠村恭久
    • Organizer
      第53回日本消化器病学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23659400
  • [Presentation] CIMP大腸癌の起源2010

    • Author(s)
      山本英一郎, 鈴木拓, 山野泰穂, 神前正幸, 甲斐正広, 菅井有, 時野隆至, 今井浩三, 篠村恭久, 豊田実
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] 未分化型胃癌におけるDNAメチル化異常の解明2010

    • Author(s)
      高丸博之, 鈴木拓, 山本英一郎, 新沼猛, 田沼徳真, 安井寛, 甲斐正広, 山本博幸, 豊田実, 篠村恭久
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] GISTにおけるエピジェネティックな異常とその臨床的意義2010

    • Author(s)
      鈴木拓, 新沼猛, 篠村恭久
    • Organizer
      第18回日本消化器病関連学会週間
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] 胃癌におけるmicroRNA34b/cのエピジェネティックな不活化2010

    • Author(s)
      鈴木拓, 山本英一郎, 高丸博之, 五十嵐伸一, 野島正寛, 山本博幸, 豊田実, 今井浩三, 篠村恭久
    • Organizer
      第6回日本消化管学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-02-19
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] GISTにおけるHNE-1低メチル化と悪性度との相関2010

    • Author(s)
      新沼猛, 鈴木拓, 野島正寛, 五十嵐伸一, 山本英一郎, 高丸博之, 田沼徳真, 山本博幸, 時野隆至, 今井浩三, 豊田実, 篠村恭久
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] microRNAプロセシングに関わるTARBP2遺伝子の消化管癌における変異及び機能解析2010

    • Author(s)
      宮本伸樹, 山本博幸, 宮本千絵, 谷口博昭, 足立靖, 日崎恵一, 井伊正則, 田沼徳真, 須河恭敬, 佐々木茂, 有村佳昭, 篠村恭久
    • Organizer
      第6回日本消化管学会学術集会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] 消化管間質腫瘍におけるLINE-1低メチル化と悪性度との相関2010

    • Author(s)
      山本英一郎, 鈴木拓, 新沼猛, 五十嵐伸一, 山本博幸, 豊田実, 篠村恭久
    • Organizer
      第21回日本消化器癌発生学会総会
    • Place of Presentation
      軽井沢
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] 次世代シークエンサーを用いた遺伝子転写開始点予測とエピゲノム解析への応用2010

    • Author(s)
      豊田実, 鈴木拓, 野島正寛, 佐々木泰史, 篠村恭久, 時野隆至, 今井浩三
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] 大腸癌においてエピジェネティックに不活化したmicroRNAの網羅的解析2009

    • Author(s)
      鈴木拓, 五十嵐伸一, 高丸博之, 新沼猛, 山本博幸, 時野隆至, 今井浩三, 豊田実, 篠村恭久
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] 多発胃癌背景胃粘膜における異常メチル化2009

    • Author(s)
      山本英一郎, 豊田実, 鈴木拓, 山本博幸, 山野泰穂, 菅井有, 今井浩三, 篠村恭久
    • Organizer
      第20回日本消化器癌発生学会総会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] 新規エピゲノム解析法の開発と消化器癌発生の分子機構2009

    • Author(s)
      豊田実, 鈴木拓, 山本英一郎, 山野泰穂, 篠村恭久
    • Organizer
      第5回日本消化管学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] 胃癌の進展におけるラミニンβ3とγ2の共発現の役割2009

    • Author(s)
      井伊正則, 山本博幸, 足立靖, 谷口博昭, 日崎恵一, 大橋広和, 田沼徳真, 國本浩明, 阿久津典之, 佐々木茂, 有村佳昭, 今井浩三, 篠村恭久
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] 大腸癌におけるIGFBP7のメチル化とCIMPとの相関2009

    • Author(s)
      鈴木拓, 五十嵐伸一, 高丸博之, 新沼猛, 山本英一郎, 野島正寛, 山本博幸, 豊田実, 今井浩三, 篠村恭久
    • Organizer
      第20回日本消化器癌発生学会総会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] JCウイルスT抗原発現陽性胃癌のジェネティックおよびエピジェネティックな異常2008

    • Author(s)
      山本博幸, 山岡聡, 宮本千絵, 井伊正則, 日崎恵一, 田沼徳真, 宮本伸樹, 奥田博介, 足立靖, 佐々木茂, 有村佳昭, 今井浩三, 篠村恭久
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] ゲノムワイドな低メチル化を指標とした胃癌の診断と発癌リスク予測への応用2008

    • Author(s)
      山本英一郎, 豊田実, 篠村恭久
    • Organizer
      第16回日本消化器関連学会週間
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] IGF-I受容体標的治療はマトリライシンの抑制を介してヒト消化器癌の浸潤を抑制する2008

    • Author(s)
      足立靖, 山本博幸, 井伊正則, 有村佳昭, 遠藤高夫, 加藤康夫, 今井浩三, 篠村恭久
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] 皺壁肥大型胃炎におけるゲノムワイドな低メチル化とCpGアイランド高メチル化の関連2008

    • Author(s)
      山本英一郎, 豊田実, 鈴木拓, 野島正寛, 丸山玲緒, 五十嵐伸一, 時野隆至, 今井浩三, 篠村恭久
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20390210
  • [Presentation] Epigenetic silencing of genes involved in signaling pathway. Symposium2007

    • Author(s)
      Toyota M, Suzuki H, Shinomura Y, Tokino T, Imai K
    • Organizer
      The 7th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
    • Place of Presentation
      Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Presentation] Frequent epigenetic inactivation of DICKKOPF family genes in gastrointestinal tumors.2007

    • Author(s)
      Suzuki H, Toyota M, Maruyama R, Imai K, Shinomura Y
    • Organizer
      35th Congress of the International Society for Oncodevelopmental Biology and Medicine
    • Place of Presentation
      Plaque, Czech Republic
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Presentation] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007

    • Author(s)
      Toyota M, Suzuki H, Maruyama R, Akino K, Watanabe Y, Sasaki Y, Imai K, Tokino T, Shinomura Y
    • Organizer
      98th Annual Meeting of American Association for Cancer Research.
    • Place of Presentation
      Los Angeles
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Presentation] Epigenetic inactivation of TCF2 in human tumors2006

    • Author(s)
      Toyota M, Terasawa K, Sagae S, Ogi K, Suzuki H, Maruyama R, Shinomura Y, Saito T, Imai K, Tokino T
    • Organizer
      97th Annual Meeting of American Association for Cancer Research
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Presentation] DNA methylation changes in cancer: application to diagnosis and therapy. Symposium2006

    • Author(s)
      Toyota M, Suzuki H, Shinomura Y, Imai K
    • Organizer
      34th Congress of the International Society for Oncodevelopmental Biology and Medicine
    • Place of Presentation
      Pasadena, USA
    • Data Source
      KAKENHI-PROJECT-17109008
  • [Presentation] 消化管間質腫瘍におけるmicroRNA遺伝子のエピジェネティックな制御

    • Author(s)
      新沼猛, 篠村恭久, 鈴木拓
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-25670371
  • [Presentation] 消化管間質腫瘍の再発に関するmicroRNAの解析

    • Author(s)
      伊早坂舞, 篠村恭久, 鈴木拓
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-25670371
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  • 95.  UEHARA Yoshimasa (50160213)
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    # of Collaborated Products: 0 results
  • 96.  YOSHIDA Minoru (80191617)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 97.  IMOTO Masaya (60213253)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 98.  FUKAZAWA Hidesuke (10218878)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 99.  KAKEYA Hideaki (00270596)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 100.  DAN Shingo (70332202)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 101.  TOMIDA Akihiro (40251483)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 102.  KAWADA Manabu (20300808)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 103.  OSADA Hiroyuki (80160836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 104.  MATSUURA Masaaki (40173794)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 105.  MIZUKAMI Tamio (80367896)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 106.  MASHIMA Tetsuo (30311228)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 107.  USHIJIMA Masaru (60328565)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 108.  TOKINO Takashi (40202197)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 109.  MIYAZONO Kohei (90209908)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 110.  INAZAWA Johji (30193551)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 111.  HIROTA Toru (50421368)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 112.  NODA Tetsuo (10183550)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 113.  SUZUKI Misao (60253720)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 114.  TAKEDA Naoki (90304998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 115.  YAGINUMA Katsuyuki (40182307)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 116.  SUGITANI Yoshinobu (80360569)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 117.  ITO Hidemi (90393123)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 118.  HOSONO Satoyo (80402600)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 119.  IWASAKI Motoki (60392338)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 120.  NAGASE Hiroki (90322073)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 121.  NISHITA Hiroki (40531257)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 122.  KONO Suminori (70128015)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 123.  HASHIMOTO Syuji (50148334)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 124.  YAMAGUCHI Kazunari (20128325)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 125.  TAKANO Atsushi (50582607)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 126.  TERAMOTO Koji (10452244)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 127.  MATSUDA Koichi (90401257)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 128.  TANAKA Yukichi (50420691)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 129.  AOKI Ichiro (00184028)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 130.  OSAMURA Yoshiyuki (10100992)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 131.  NAKAMURA Naoya (50227922)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 132.  SUZUKI Noboru (40235982)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 133.  TAJIRI Michihiko (00449117)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 134.  KAWASAKI Takashi (20377188)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 135.  YOKOSE Tomoyuki (10221665)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 136.  YANAGISAWA Kiyoshi (20372112)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 137.  HIRAKAWA Akihiro (90609330)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 138.  IIJIMA Yoshihiko (50584679)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 139.  ZEMBUTSU Hitoshi (90372820)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 140.  SASAKI Yasushi (70322328)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 141.  IDOGAWA Masashi (00404749)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 142.  MARUYAMA Reo (60607985)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 143.  KAI Masahiro (80260777)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 144.  遠藤 高夫 (40191928)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 145.  中村 祐輔 (70217909)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 146.  FUJIMOTO Takashi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 147.  KAWACHI Masanori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 148.  YAMADA Yuya
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 149.  中原 征則
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 150.  上山 晴美
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 151.  TAKANO Ken-ichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 152.  TANIGUCHI Hiroaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 153.  NAGAISHI Kanna
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 154.  HIDA Tokimasa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 155.  渡辺 能行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 156.  渡辺 俊樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 157.  山下 健太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 158.  山本 英一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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