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HIRAKAWA AKIHIRO  平川 晃弘

… Alternative Names

HIRAKAWA Akihiro  平川 晃弘

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Researcher Number 90609330
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-2580-7460
Affiliation (Current) 2025: 東京科学大学, 大学院医歯学総合研究科, 教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
2020: 東京医科歯科大学, 医学部附属病院, 教授
2017 – 2019: 東京大学, 大学院医学系研究科(医学部), 特任准教授
2017: 東京大学, 大学院医学系研究科, 特任准教授
2016: 東京大学, 大学院医学系研究科, 准教授
2013 – 2016: 名古屋大学, 医学部附属病院, 講師
2015: 名古屋大学, 医学部附属病院先端医療・臨床研究支援センター, 講師
Review Section/Research Field
Principal Investigator
Statistical science / Basic Section 60030:Statistical science-related / Sections That Are Subject to Joint Review: Basic Section60030:Statistical science-related , Basic Section61030:Intelligent informatics-related / Basic Section 61030:Intelligent informatics-related
Except Principal Investigator
Biological Sciences / Statistical science / Statistical science / Neurology
Keywords
Principal Investigator
がん / ベイズ流アプローチ / ベイズ流デザイン / がん臨床試験 / 用量探索法 / ベイズ統計学 / 生物統計学 / 臨床試験方法論 / バスケットデザイン / マスタープロトコル … More / 臨床統計学 / 分子標的薬 / 臨床試験デザイン / 用量探索デザイン / 第I相試験 / 用量探索 / バスケット型臨床試験 / バスケット試験 / アダプティブデザイン / 縮小推定 / ベイズ統計 / 併用療法 / 第I相試験 / 臨床試験論 … More
Except Principal Investigator
シーケンス解析 / 稀なゲノム変異 / 統合失調症 / ゲノム解析 / 精神疾患 / グリア / 脳神経疾患、生体生命情報学 / 神経科学、脳・神経 / 生体生命情報学 / 脳神経疾患 / 脳・神経 / 神経科学 / ゲノム / 予測解析 / バイオマーカー / 統計解析 / ゲノムデータ解析 / ゲノムデータの解析 / 診断法開発 / 先端医療技術の開発 / 臨床試験の計画と解析 / 先端医療技術 / 個別化医療 / データ解析 / 統計的デザイン / 臨床試験 / がん分子標的薬剤 / ATL発症リスク / ATL発がん機序 / がん化学予防 / 分子疫学コーホート研究 / ATL発症予防 / 国際交流 / 個別化がん予防 / ゲノム・エピゲノム解析支援 / アカデミア創薬 / 次世代分子解析技術 / ゲノムコーホート研究 / 病理形態学 / 遺伝子改変マウス / 国際研究者交流 / 若手支援 / 疾患レジストリー / バイアス / 介入研究 / コホート研究 / レジストリー / 疾患登録 / 遺伝子多型 / ゲノム遺伝子 / 一塩基多型 / 重症度スケール / 予後因子 / 疾患コホート / 筋萎縮性側索硬化症 Less
  • Research Projects

    (10 results)
  • Research Products

    (77 results)
  • Co-Researchers

    (155 People)
  •  がん早期臨床試験のデザインと統計解析法の新展開Principal Investigator

    • Principal Investigator
      平川 晃弘
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 60030:Statistical science-related
      Basic Section 61030:Intelligent informatics-related
      Sections That Are Subject to Joint Review: Basic Section60030:Statistical science-related , Basic Section61030:Intelligent informatics-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of statistical methodology for evaluating heterogeneity of treatment effects in basket clinical trialsPrincipal Investigator

    • Principal Investigator
      Hirakawa Akihiro
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 60030:Statistical science-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Bayesian dose-finding designs for longitudinal toxicity data in molecularly targeted agentsPrincipal Investigator

    • Principal Investigator
      Hirakawa Akihiro
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Statistical science
    • Research Institution
      Tokyo Medical and Dental University
      The University of Tokyo
  •  Development trial design in rare disease using registry data

    • Principal Investigator
      Kada Akiko
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Statistical science
    • Research Institution
      National Hospital Organization Nagoya Medical Center
  •  Dose-finding methods for molecularly targeted agentsPrincipal Investigator

    • Principal Investigator
      Hirakawa Akihiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Statistical science
    • Research Institution
      The University of Tokyo
      Nagoya University
  •  Searching for factors associated with progression and prognosis in patients with sporadic amyotrophic lateral sclerosis

    • Principal Investigator
      Atsuta Naoki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Nagoya University
  •  A dose-finding approach based on shrunken predictive probability for combinations of two agents in phase I trialsPrincipal Investigator

    • Principal Investigator
      HIRAKAWA Akihiro
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Statistical science
    • Research Institution
      Nagoya University
  •  Identification of schizophrenia subgroups caused by white matter and myelin disorders

    • Principal Investigator
      Ozaki Norio
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Nagoya University
  •  Design and statistical analysis in translational clinical trials

    • Principal Investigator
      Matsui Shigeyuki
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Statistical science
    • Research Institution
      Nagoya University
      The Institute of Statistical Mathematics
  •  Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

    • Principal Investigator
      IMAI Kohzoh, 中村 祐輔
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      The University of Tokyo

All 2023 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book Patent

  • [Book] Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents2018

    • Author(s)
      Hirakawa A, Sato H, Daimon T, Matsui S
    • Total Pages
      104
    • Publisher
      Springer
    • ISBN
      4431555722
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Book] Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents2018

    • Author(s)
      Hirakawa, A., Sato, H., Daimon, T., Matsui, S.
    • Total Pages
      104
    • Publisher
      Springer
    • ISBN
      9784431555728
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Book] Frontiers of Biostatistical Methods and Applications in Clinical Oncology2017

    • Author(s)
      Hirakawa A, Matsui S.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Book] Frontiers of Biostatistical Methods and Applications in Clinical Oncology2017

    • Author(s)
      Hirakawa A, H Sato
    • Publisher
      Speinger
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Book] 実践でわかる!Rによる統計遺伝学2016

    • Author(s)
      Andrea S. Foulkes原著, 西山毅監訳, 菱田朝陽, 中杤昌弘, 室谷健太, 平川晃弘翻訳
    • Total Pages
      267
    • Publisher
      丸善出版
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Book] Design and Analysis of Clinical Trials for Predictive Medicine2015

    • Author(s)
      Daimon T, Hirakawa A, Matsui S.
    • Publisher
      CRC Press
    • Data Source
      KAKENHI-PROJECT-25730015
  • [Book] Phase I dose-finding designs and their applicability to targeted therapies. Design and Analysis of Clinical Trials for Predictive Medicine.2014

    • Author(s)
      Daimon T, Hirakawa A, Matsui S.
    • Publisher
      CRC Press
    • Data Source
      KAKENHI-PROJECT-25730015
  • [Book] Developments in Statistical Evaluation of Clinical Trials2014

    • Author(s)
      Hirakawa A, Matsui S.
    • Total Pages
      361
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-25730015
  • [Book] Dose-finding for two-agent combination phase I trials. Development in Statistical Evaluation of Clinical Trials2014

    • Author(s)
      Hirakawa A, Matsui S.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-25730015
  • [Book] Developments in Statistical Evaluation of Clinical Trials2014

    • Author(s)
      Hirakawa A, Matsui S
    • Total Pages
      361
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-24240042
  • [Journal Article] Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with <i>MDM2</i> Amplification: An Open-Label Phase Ib/II Study2023

    • Author(s)
      Koyama Takafumi、Shimizu Toshio、Kojima Yuki、Sudo Kazuki、Okuma Hitomi Sumiyoshi、Shimoi Tatsunori、Ichikawa Hitoshi、Kohsaka Shinji、Sadachi Ryo、Hirakawa Akihiro、Yoshida Akihiko、Ando Reiko Makihara、Ueno Toshihide、Yanagaki Mitsuru、Matsui Naoko、Nakamura Kenichi、Yamamoto Noboru、Yonemori Kan
    • Journal Title

      Cancer Discovery

      Volume: 13 Issue: 8 Pages: 1814-1825

    • DOI

      10.1158/2159-8290.cd-23-0419

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15614, KAKENHI-PROJECT-20K11703, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-21H03062
  • [Journal Article] Trastuzumab Deruxtecan for Human Epidermal Growth Factor Receptor 2?Expressing Advanced or Recurrent Uterine Carcinosarcoma (NCCH1615): The STATICE Trial2023

    • Author(s)
      Nishikawa T、Hasegawa K、Matsumoto K、Mori M、Hirashima Y、Takehara K、Ariyoshi K、Kato T、Yagishita S、Hamada A、Kawasaki M、Kawashima S、Tomatsuri S、Nagasaka Y、Yoshida H、Machida R、Hirakawa A、Nakamura K、Yonemori K
    • Journal Title

      Journal of Clinical Oncology

      Volume: 41 Issue: 15 Pages: 2789-2799

    • DOI

      10.1200/jco.22.02558

    • Open Access
    • Data Source
      KAKENHI-PROJECT-20K11703
  • [Journal Article] Racial differences in longitudinal toxicities of anticancer agents in early phase cancer clinical trials2023

    • Author(s)
      Mizusawa Junki、Sato Hioryuki、Rubinstein Larry V.、Fujiwara Takeo、Yonemori Kan、Hirakawa Akihiro
    • Journal Title

      Cancer Medicine

      Volume: 12 Issue: 17 Pages: 18098-18109

    • DOI

      10.1002/cam4.6370

    • Open Access
    • Data Source
      KAKENHI-PROJECT-20K11703
  • [Journal Article] Enhancement of Bayesian optimal interval design by accounting for overdose and underdose errors trade-offs2023

    • Author(s)
      Sadachi Ryo、Sato Hiroyuki、Fujiwara Takeo、Hirakawa Akihiro
    • Journal Title

      Journal of Biopharmaceutical Statistics

      Volume: 15 Issue: 1 Pages: 1-20

    • DOI

      10.1080/10543406.2023.2275766

    • Data Source
      KAKENHI-PROJECT-20K11703
  • [Journal Article] Practical basket design for binary outcomes with control of family-wise error rate2023

    • Author(s)
      Junichi Asano, Hiroyuki Sato, Akihiro Hirakawa
    • Journal Title

      BMC Medical Research Methodology

      Volume: 23 Issue: 1

    • DOI

      10.1186/s12874-023-01872-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K11703
  • [Journal Article] A dose-finding approach for genomic patterns in phase I trials.2020

    • Author(s)
      Kaneko S, Hirakawa A, Kakurai Y, Hamada C.
    • Journal Title

      Journal of Biopharmaceutical Statistics

      Volume: - Issue: 5 Pages: 834-853

    • DOI

      10.1080/10543406.2020.1744619

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Journal Article] A Bayesian basket trial design accounting for uncertainties of homogeneity and heterogeneity of treatment effect among subpopulations.2020

    • Author(s)
      2.Asano J, Hirakawa A
    • Journal Title

      Pharmaceutical Statistics

      Volume: 19 Issue: 6 Pages: 975-1000

    • DOI

      10.1002/pst.2049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K11703, KAKENHI-PROJECT-17K00045
  • [Journal Article] Dose individualization and variable selection using Bayesian Lasso in early phase dose-finding trials2019

    • Author(s)
      Kakurai Y, Kaneko S, Hamada C, Hirakawa A
    • Journal Title

      Applied Statistics

      Volume: 68 Issue: 2 Pages: 445-460

    • DOI

      10.1111/rssc.12326

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Journal Article] A comparative study of longitudinal toxicities of cytotoxic drugs, molecularly targeted agents, immunomodulatory drugs, and cancer vaccines2019

    • Author(s)
      Hirakawa A, Sudo K, Yonemori K, Sadachi R, Kinoshita F, Kobayashi Y, Okuma SH, Kawachi A, Tamura K, Fujiwara Y, Rubinstein L, Takebe N.
    • Journal Title

      Clinical Pharmacology & Therapeutics

      Volume: 106 Issue: 4 Pages: 803-809

    • DOI

      10.1002/cpt.1442

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Journal Article] Pragmatic dose-escalation methods incorporating relative dose intensity assessment for molecularly targeted agents in phase I trials.2019

    • Author(s)
      Hirakawa A, Tanaka Y, Kaneko S.
    • Journal Title

      Contemporary Clinical Trial Communications

      Volume: 16 Pages: 100489-100489

    • DOI

      10.1016/j.conctc.2019.100489

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Journal Article] マスタープロトコルに基づくがん臨床試験2019

    • Author(s)
      平川晃弘,浅野淳一,佐藤宏征,手良向聡
    • Journal Title

      計量生物学

      Volume: 39 Pages: 85-101

    • NAID

      130007644694

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Journal Article] がん臨床試験におけるベイズ流バスケットデザインの理論と実装2019

    • Author(s)
      平川晃弘,浅野淳一,佐藤宏征,橋本大哉,手良向聡
    • Journal Title

      計量生物学

      Volume: 39 Pages: 103-122

    • NAID

      130007644700

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Journal Article] Potential utility of a longitudinal relative dose intensity of molecularly targeted agents in phase 1 dose-finding trial.2018

    • Author(s)
      Hirakawa A, Yonemori K, Kinoshita F, Kobayashi Y, Okuma H. Kawachi A, Tamura K, Fujiwara Y, Rubinstein L, Harris PJ, Takebe N.
    • Journal Title

      Cancer Science

      Volume: 1 Issue: 1 Pages: 207-214

    • DOI

      10.1111/cas.13436

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Journal Article] Two-stage approach based on zone and dose findings for two-agent combination phase I/II trials2018

    • Author(s)
      Shimamura F, Hamada C, Matsui S, Hirakawa A
    • Journal Title

      Journal of Biopharmaceutical Statistics

      Volume: 印刷中 Issue: 6 Pages: 999-999

    • DOI

      10.1080/10543406.2018.1434190

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H06299, KAKENHI-PROJECT-15K15948
  • [Journal Article] Master protocol trials in oncology: Review and new trial designs2018

    • Author(s)
      33.Hirakawa A, Asano J, Sato H, Teramukai S
    • Journal Title

      Contemporary Clinical Trial Communications

      Volume: 12 Pages: 1-8

    • DOI

      10.1016/j.conctc.2018.08.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K00045, KAKENHI-PROJECT-18K11194, KAKENHI-PROJECT-15K00067
  • [Journal Article] Authors' Reply2016

    • Author(s)
      Hirakawa A, Sato H
    • Journal Title

      Statistics in Medicine

      Volume: 35 Issue: 3 Pages: 479-480

    • DOI

      10.1002/sim.6751

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Journal Article] Effect of design specifications in dose-finding trials for combination therapies in oncology2016

    • Author(s)
      Hirakawa A, Sato H, Gosho M
    • Journal Title

      Pharmaceutical Statistics

      Volume: 15 Issue: 6 Pages: 531-540

    • DOI

      10.1002/pst.1770

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Journal Article] レジストリーデータは医薬品開発に活用できるか?2016

    • Author(s)
      平川晃弘
    • Journal Title

      薬理と治療

      Volume: 44

    • Data Source
      KAKENHI-PROJECT-15K00067
  • [Journal Article] Age of onset differentially influences the progression of regional dysfunction in sporadic amyotrophic lateral sclerosis.2016

    • Author(s)
      Yokoi D, Atsuta N, Watanabe H, Nakamura R, Hirakawa A, Ito M, Watanabe H, Katsuno M, Izumi Y, Morita M, Taniguchi A, Oda M, Abe K, Mizoguchi K, Kano O, Kuwabara S, Kaji R, Sobue G; JaCALS.
    • Journal Title

      J Neurol.

      Volume: Epub ahead of print

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25461277
  • [Journal Article] A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN.2016

    • Author(s)
      Watanabe H, Atsuta N, Hirakawa A, Nakamura R, Nakatochi M, Ishigaki S, Iida A, Sobue G.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: in press Issue: 8 Pages: 851-8

    • DOI

      10.1136/jnnp-2015-311541

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09310, KAKENHI-PROJECT-26461319, KAKENHI-PROJECT-25461277, KAKENHI-PROJECT-26670439, KAKENHI-ORGANIZER-26117001, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15K15338, KAKENHI-PROJECT-15K19485
  • [Journal Article] An adaptive dose-finding method using a change-point model for molecularly targeted agents in phase I trials.2016

    • Author(s)
      Sato H, Hirakawa A, Hamada C
    • Journal Title

      Statistics in Medicine

      Volume: 35 Issue: 23 Pages: 4093-4109

    • DOI

      10.1002/sim.6981

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Journal Article] A dose-finding method based on multiple dosing in two-agent combination phase I trials.2015

    • Author(s)
      Kakurai Y, Hirakawa A, Hamada C
    • Journal Title

      Journal of Biopharmaceutical Statistics

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25730015
  • [Journal Article] Operating characteristics of restrictions on skipping dose level for adaptive dose-finding method in two-agent phase I trials2015

    • Author(s)
      Hirakawa A, Matsui S
    • Journal Title

      Japanese Journal of Biometrics

      Volume: 36 Pages: 1-12

    • NAID

      130005097958

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Journal Article] A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies2015

    • Author(s)
      Hirakawa A, Wages NA, Sato H, Matsui S
    • Journal Title

      Statistics in Medicine

      Volume: 34 Issue: 24 Pages: 3194-3213

    • DOI

      10.1002/sim.6533

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15948, KAKENHI-PROJECT-24240042
  • [Journal Article] Operating characteristics of restrictions on skipping dose level for adaptive dose-finding method in two-agent phase I trials2015

    • Author(s)
      Hirakawa A, Matsui S
    • Journal Title

      Japanese Journal of Biometrics

      Volume: 36 Pages: 1-12

    • NAID

      130005097958

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24240042
  • [Journal Article] Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients.2014

    • Author(s)
      Watanabe H, Atsuta N, Nakamura R, Hirakawa A, Watanabe H, Ito M, Senda J, Katsuno M, Izumi Y, Morita M, Tomiyama H, Taniguchi A, Aiba I, Abe K, Mizoguchi K, Oda M, Kano O, Okamoto K, Kuwabara S, Hasegawa K, Imai T, Aoki M, Tsuji S, Nakano I, Kaji R, Sobue G.
    • Journal Title

      Amyotroph Lateral Scler Frontotemporal Degener.

      Volume: Epub ahead of print Issue: 3-4 Pages: 230-6

    • DOI

      10.3109/21678421.2014.990036

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25461277, KAKENHI-PROJECT-26670439, KAKENHI-PLANNED-26117002, KAKENHI-ORGANIZER-26117001
  • [Journal Article] Response to Letter to Editor by Drs Wages et al.2014

    • Author(s)
      Hirakawa A, Matsui S.
    • Journal Title

      Statistics in Medicine

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25730015
  • [Journal Article] Response to letter to the editor by Dr Wages et al2014

    • Author(s)
      Hirakawa A, Matsui S
    • Journal Title

      Stat Med

      Volume: 33 Issue: 12 Pages: 2159-2160

    • DOI

      10.1002/sim.5972

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-25280008, KAKENHI-PROJECT-25730015
  • [Journal Article] The construction of risk prediction models using GWAS data and its application to a type 2 diabetes prospective cohort2014

    • Author(s)
      Shigemizu D, Abe T, Morizono T, Johnson TA, Boroevich KA, Hirakawa Y, Ninomiya T, Kiyohara Y, Kubo M, Nakamura Y, Maeda S, Tsunoda T
    • Journal Title

      PLoS One

      Volume: 9 Issue: 3 Pages: e92549-e92549

    • DOI

      10.1371/journal.pone.0092549

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22134008, KAKENHI-PROJECT-221S0001
  • [Journal Article] Comparative proteomics analysis of gastric cancer stem cells2014

    • Author(s)
      Morisaki T, Yashiro M, Kakehashi A, Inagaki A, Kinoshita H, Fukuoka T, Kasashima H, Masuda G, Sakurai K, Kubo N, Muguruma K, Ohira M, Wanibuchi H, Hirakawa K.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 11 Pages: e110736-e110736

    • DOI

      10.1371/journal.pone.0110736

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23390329, KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-221S0001
  • [Journal Article] Overview of Model-Based Dose-Finding Methods for Combinations of Two Agents in Phase I Oncology Trials2014

    • Author(s)
      平川晃弘,松井茂之
    • Journal Title

      Japanese Journal of Biometrics

      Volume: 34 Issue: 2 Pages: 81-97

    • DOI

      10.5691/jjb.34.81

    • NAID

      130004721700

    • ISSN
      0918-4430, 2185-6494
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24240042
  • [Journal Article] Bayesian model averaging continual reassessment method for bivariate binary efficacy and toxicity outcomes in phase I oncology trials.2014

    • Author(s)
      Asakawa T, Hirakawa A, Hamada C.
    • Journal Title

      Journal of Biopharmaceutical Statistics

      Volume: 23 Issue: 2 Pages: 310-325

    • DOI

      10.1080/10543406.2013.863779

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25730015
  • [Journal Article] Neck weakness is a potent prognostic factor in sporadic amyotrophic lateral sclerosis patients.2013

    • Author(s)
      Nakamura R, Atsuta N, Watanabe H, Hirakawa A, Watanabe H, Ito M, Senda J, Katsuno M, Tanaka F, Izumi Y, Morita M, Ogaki K, Taniguchi A, Aiba I, Mizoguchi K, Okamoto K, Hasegawa K, Aoki M, Kawata A, Abe K, Oda M, Konagaya M, Imai T, Nakagawa M, Tsuji S, Kaji R, Nakano I, Sobue G.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 84 Issue: 12 Pages: 1365-1371

    • DOI

      10.1136/jnnp-2013-306020

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-22129005, KAKENHI-PROJECT-23591231, KAKENHI-PROJECT-24406030, KAKENHI-PROJECT-25461277, KAKENHI-PROJECT-25461312
  • [Journal Article] MUC5AC protects pancreatic cancer cells from TRAIL-induced death pathways.2013

    • Author(s)
      Hoshi, H., Sawada, T., Uchida, M., Iijima, H., Kimura, K., Hirakawa, K., Wanibuchi, H.
    • Journal Title

      Int J Oncol

      Volume: 42 Issue: 3 Pages: 887-893

    • DOI

      10.3892/ijo.2013.1760

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] がん第I相試験における2剤併用療法の用量探索法:最近の展開2013

    • Author(s)
      平川晃弘,松井茂之
    • Journal Title

      計量生物学

      Volume: 34 Pages: 81-97

    • NAID

      130004721700

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25730015
  • [Journal Article] A dose-finding approach based on shrunken predictive probability for combinations of two agents in phase I trials2013

    • Author(s)
      Hirakawa A, Hamada C, Matsui S
    • Journal Title

      Statistics in Medicine

      Volume: 32 Issue: 26 Pages: 4515-4525

    • DOI

      10.1002/sim.5843

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-25730015
  • [Patent] 急速進行型孤発性ALSの検査方法、検査キット、及び医薬のスクリーニング方法2015

    • Inventor(s)
      祖父江元、熱田直樹、渡邉はづき、平川晃弘、中杤昌弘
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-051093
    • Filing Date
      2015-03-13
    • Data Source
      KAKENHI-PROJECT-25461277
  • [Patent] 統合失調症マーカーセット及びその利用(リンパ球を用いた統合失調症の診断キット開発).2013

    • Inventor(s)
      尾崎紀夫, 永井拓, 平川晃弘, 國本正子, 吉見陽et al.
    • Industrial Property Rights Holder
      国立大学法人 名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-10-03
    • Data Source
      KAKENHI-PLANNED-25117010
  • [Presentation] 希少疾患に対する治療効果の定量化についての一考察2023

    • Author(s)
      平川晃弘
    • Organizer
      JPMA「Rare diseaseの臨床開発における治療効果推測の現状と課題」シンポジウム
    • Data Source
      KAKENHI-PROJECT-20K11703
  • [Presentation] 臨床試験方法論のパラダイムシフト: プラットフォーム試験の有用性2023

    • Author(s)
      平川晃弘
    • Organizer
      第50回日本集中治療医学会
    • Data Source
      KAKENHI-PROJECT-20K11703
  • [Presentation] Under-parameterized design with unit information prior in oncology basket trials2023

    • Author(s)
      Kitabayashi R, Sato H, Hirakawa A
    • Organizer
      ENAR 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K11703
  • [Presentation] 早期用量探索試験のデザインの変遷2023

    • Author(s)
      平川晃弘
    • Organizer
      2023年度計量生物学講演会
    • Data Source
      KAKENHI-PROJECT-20K11703
  • [Presentation] リアルワールドデータを用いた次世代の臨床試験デザイン2023

    • Author(s)
      平川晃弘
    • Organizer
      第65回日本婦人科腫瘍学会
    • Data Source
      KAKENHI-PROJECT-20K11703
  • [Presentation] Utility of Bayesian single-arm design in new drug application for rare cancers in Japan: application to basket trial data2019

    • Author(s)
      Hirakawa A
    • Organizer
      6th International Society of Biopharmaceutical Statistics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Presentation] A Basket Trial Design using Bayesian Model Averaging.2019

    • Author(s)
      Hirakawa A, Sadachi R
    • Organizer
      ENAR 2019 Spring Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Presentation] A clustering-based basket design2019

    • Author(s)
      Hirakawa A
    • Organizer
      3rd Pacific Rim Cancer Biostatistics Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Presentation] Heterogeneity Assessment of Treatment Effect among Subpopulations in Basket Trials2019

    • Author(s)
      Sadachi R, Hirakawa A
    • Organizer
      ENAR 2019 Spring Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Presentation] Dose-Finding Method for Molecularly Targeted Agents Incorporating the Relative Dose Intensity in Phase I Oncology Clinical Trials.2019

    • Author(s)
      Tanaka Y, Sozu T, Hirakawa A
    • Organizer
      ENAR 2019 Spring Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K00045
  • [Presentation] がん分子標的薬の用量探索法2017

    • Author(s)
      佐藤宏征, 平川晃弘, 浜田知久馬
    • Organizer
      日本計量生物学会年会
    • Place of Presentation
      中央大学(東京都文京区)
    • Year and Date
      2017-03-16
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Presentation] Dose individualization based on multiple gene mutations for molecularly targeted agents2017

    • Author(s)
      Kakurai Y, Hirakawa A, Hamada C
    • Organizer
      日本計量生物学会年会
    • Place of Presentation
      中央大学(東京都文京区)
    • Year and Date
      2017-03-16
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Presentation] Statistical Consideration for Novel Dose Escalation Methods in Phase 1 Oncology Trials.2017

    • Author(s)
      Hirakawa A
    • Organizer
      2nd NCCH Workshop
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Presentation] 抗がん剤併用療法の第I/II 相試験における2 段階デザインを用いた用量探索2017

    • Author(s)
      島村文也, 平川晃弘, 浜田知久馬
    • Organizer
      日本計量生物学会年会
    • Place of Presentation
      中央大学(東京都文京区)
    • Year and Date
      2017-03-16
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Presentation] 抗がん剤第Ⅰ相試験における経時データを使用した用量探索の方法に関する研究2017

    • Author(s)
      加藤凌輔, 平川晃弘, 浜田知久馬
    • Organizer
      日本計量生物学会年会
    • Place of Presentation
      中央大学(東京都文京区)
    • Year and Date
      2017-03-16
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Presentation] Two-stage dose and zone finding method for two agent combination phase 1/2 trials2017

    • Author(s)
      Hirakawa A
    • Organizer
      2nd Pacific Rim Cancer Biostatistics Workshop
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Presentation] レジストリーデータは医薬品開発に活用できるか?2016

    • Author(s)
      平川晃弘
    • Organizer
      日本臨床試験学会第7回学術集会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-03-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K00067
  • [Presentation] 個別化医療を目指した先進的試験デザイン2016

    • Author(s)
      平川晃弘
    • Organizer
      第13回DIA日本年会
    • Place of Presentation
      東京都江東区
    • Year and Date
      2016-11-13
    • Data Source
      KAKENHI-PROJECT-15K00067
  • [Presentation] 疾患レジストリを用いた医薬品開発の効率化2016

    • Author(s)
      平川晃弘
    • Organizer
      第13回DIA日本年会
    • Place of Presentation
      東京都江東区
    • Year and Date
      2016-11-13
    • Data Source
      KAKENHI-PROJECT-15K00067
  • [Presentation] Dose-finding designs for combination therapies in oncology2015

    • Author(s)
      Hirakawa A.
    • Organizer
      Pacific Rim Cancer Biostatistics Conference
    • Place of Presentation
      シアトル アメリカ
    • Year and Date
      2015-08-14
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Presentation] An adaptive dose-finding method using a change-point model for molecularly targeted agents in phase I trials2015

    • Author(s)
      Sato H, Hirakawa A, Hamada C.
    • Organizer
      East Asia Regional Biometric Conference 2015
    • Place of Presentation
      福岡県福岡市 九州大学
    • Year and Date
      2015-12-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Presentation] A rapid functional decline type of sporadic ALS is linked to low expression of TTN2015

    • Author(s)
      Naoki Atsuta, Hazuki Watanabe, Akihiro Hirakawa, Ryoichi Nakamura, Masahiro Nakatochi, Shinsuke Ishigaki, Aritoshi Iida, Shiro Ikegawa, Masahisa Katsuno, Yuishin Izumi, Mitsuya Morita, Akira Taniguchi, Koji Abe, Kouichi Mizoguchi, Osamu Kano, Takashi Imai, Masashi Aoki, Kenji Nakashima, Ryuji Kaji, Gen Sobue
    • Organizer
      26th International Symposium on ALS/MND
    • Place of Presentation
      Orlando( USA)
    • Year and Date
      2015-12-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461277
  • [Presentation] 医薬品開発におけるバイオマーカーの活用2015

    • Author(s)
      平川晃弘
    • Organizer
      PhUSE 2015
    • Place of Presentation
      東京都文京区 エーザイ株式会社
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Presentation] Dose finding design for two-agent combination trials2015

    • Author(s)
      Shimamura F, Hirakawa A, Hamada C
    • Organizer
      East Asia Regional Biometric Conference 2015
    • Place of Presentation
      福岡県福岡市 九州大学
    • Year and Date
      2015-12-20
    • Data Source
      KAKENHI-PROJECT-15K15948
  • [Presentation] Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients2014

    • Author(s)
      Hazuki Watanabe, Naoki Atsuta, Ryoichi Nakamura, Akihiro Hirakawa, Hirohisa Watanabe, Mizuki Ito, Masahisa Katsuno, Yuishin Izumi, Mitsuya Morita, Hiroyuki Tomiyama, Akira Taniguchi, Koji Abe, Kouichi Mizoguchi, Osamu Kano, Satoshi Kuwabara, Takashi Imai, Masashi Aoki, Ryuji Kaji, Imaharu Nakano, Gen Sobue
    • Organizer
      The 25th international symposium on ALS/MND
    • Place of Presentation
      Brussels, Belgium,The Square, Brussels Meeting Centre
    • Year and Date
      2014-12-06
    • Data Source
      KAKENHI-PROJECT-25461277
  • [Presentation] ALSの進行を規定する因子の探索同定2014

    • Author(s)
      熱田直樹、渡辺はづき、中村亮一、平川晃弘、中杤昌弘、渡辺宏久、伊藤瑞規、千田譲、和泉唯信、梶龍兒、森田光哉、富山弘幸、谷口彰、溝口功一、狩野修、阿部康二、中野今治、飯田有俊、池川志郎、祖父江元
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡県福岡市(福岡国際会議場)
    • Year and Date
      2014-05-24
    • Data Source
      KAKENHI-PROJECT-25461277
  • [Presentation] 抗がん剤併用療法第I相試験におけるコホート分割法に基づくベイズ流用量探索法2013

    • Author(s)
      加倉井靖之,平川晃弘,浜田知久馬
    • Organizer
      日本計量生物学会
    • Place of Presentation
      パルセいいざか(福島市)
    • Data Source
      KAKENHI-PROJECT-25730015
  • [Presentation] がん第I 相試験における用量探索法の最近の展開

    • Author(s)
      平川晃弘
    • Organizer
      科研費シンポジウム
    • Place of Presentation
      福岡県福岡市(九州大学医学部)
    • Year and Date
      2015-02-02 – 2015-02-04
    • Data Source
      KAKENHI-PROJECT-25730015
  • [Presentation] ALSの進行を規定する因子の探索同定

    • Author(s)
      熱田直樹、渡辺はづき、中村亮一、平川晃弘、中杤昌弘、渡辺宏久、伊藤瑞規、千田譲、和泉唯信、梶龍兒、森田光哉、富山弘幸、谷口彰、溝口功一、狩野修、阿部康二、中野今治、飯田有俊、池川志郎、祖父江元
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Data Source
      KAKENHI-PROJECT-25461277
  • 1.  MATSUURA Masaaki (40173794)
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  • 2.  DAIMON Takashi (40372156)
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