UEHARA Yoshimasa 上原至雅

… Alternative Names

UEHARA YOSHIMASA 上原至雅

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Researcher Number	50160213
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2015 – 2016: 岩手医科大学, 薬学部, 教授 2011 – 2013: 岩手医科大学, 薬学部, 教授 2007 – 2009: Iwate Medical University, 薬学部, 教授 1999 – 2006: 国立感染症研究所, 生物活性物質部, 部長 2000 – 2004: 国立感染症研究所, 生物活性物質部, 部長(研究職) … More 1999: 国立感染症研究所, 生物活性物質部, 室長(研究職) 1997 – 1998: 国立感染症研究所, 生物活性物質部, 室長 1992 – 1996: 国立予防衛生研究所, 生物活性物質部, 室長 1990 – 1991: 国立予防衛生研究所, 抗生物質部, 室長 1986 – 1989: 国立予防衛生研究所, 室長 1987: 国立予研, 抗生物質部, 室長 Less
Review Section/Research Field	Principal Investigator Biological Sciences / 医薬分子機能学 / Clinical oncology Except Principal Investigator Biological Sciences / Drug development chemistry
Keywords	Principal Investigator がん遺伝子 / シグナル伝達 / アポトーシス / 足場非依存性増殖 / スクリーニング / ハービマイシン / 薬学 / rapamycin / anicequol / 乳がん … More / anoikis / MEK阻害剤 / 接着 / 細胞接着 / U0126 / 血管新生 / 転移 / がん抑制遺伝子 / 阻害剤 / プロテインキナーゼ / チロシンキナーゼ / スクリ-ニング / 抗生物質 / ハ-ビマイシン / チロシンキナ-ゼ / TRANSCRIPTION / TRANSFORMATION / HERBIMYCIN A / POLY (HEMA) / ONCOGENIC SIGNALS / ADHESION / ANCHORAGE INDEPENENT GROWTH / RAS / 足場依存性 / ファルネシルトランスフェラーゼ / トランスフォメーション / ファルネシルトランスフェラージ / トランスフォーメーション / ラディシコール / polyHEMA / 癌化シグナル / 足場非依存増殖 / 増殖の足場依存性 / アクチンケーブル / 細胞骨格蛋白 / 癌形質 / 抗がん剤 / がん / DKK1 / 遺伝子発現 / 造腫瘍性 / 幹細胞 / 遺伝子発現プロファイル / 次世代シークエンサー / 次世代シーケンサー / Wntシグナル / TGF-beta / ドキソルビシン / Her2 / ALDH / CD133 / 乳がん幹細胞 / geldanamycin / mTOR / sesquiterpene / tamoxifen / 25-hydroxycholesterol / K-ras / BimEL / B-RAF / MEK-ERK経路 / pDGF / p38MAPK経路 / 癌 / resorcylic acid lactones / Hsp90阻害剤 / BH3-only protein / hypothemycin / TPA / MIA PaCa-2 / 乳がん細胞 / spicamycin / ERK / apoptosis / Bim / BH3-only蛋白質 / アノイーキス / 転写因子 / がん転移 / マクロライド / チロシンキナーゼ阻害剤 / 細胞周期 / がん化シグナル / Ets-1 / CDKインヒビター / cyclin D1 / p21^<waf1> / RB / Ablチロシンキナーゼ / Srcチロシンキナーゼ / p7056キナーゼ / MAPキナーゼ / Srcがん遺伝子 / Rasがん遺伝子 / 制がん剤 / 薬剤耐性 / IL-6 / 制がん物質 / エンジェルマイシン / EGFレセプター / 細胞分化 / 熱ショック蛋白 … More Except Principal Investigator セファランチン / 抗がん剤 / チロシンキナーゼ / アファチニブ / 薬剤耐性変異 / アザアメラリン / オシメルチニブ / ゲフィチニブ / L858R/T790M/C797S / L858R/T790M / アザラメラリン / ラメラリン / オシメルチニブ耐性 / ゲフィチニブ耐性 / L858R/T790M/C797S変異 / L858R/T790M変異 / EGFR-TKI / 非小細胞肺がん / 細胞増殖制御 / 増殖信号伝達 / がん遺伝子 / 増殖因子 / 細胞癌化 / 燐酸化チロシン / methylthioneine / GSTπ / dihydropyridine / O^6-methylguanine / glutathione生合成阻害物質 / bleomycin不活化酵素 / myc / ras / src / oncogene / D.H.F.R遺伝子 / トランスセクタント / ブレオマイシン不活化酵素阻害剤 / イノシンモノ燐酸脱水素酵素 / オキザノシン / 多剤耐性ヒト癌KB変異株 / DHFR遺伝子 / ダイハイドロピリジン誘導体 / 抗腫瘍性プロスタグランジン / チロジンキナーゼ癌遺伝子群 / アンサマイシン系ハービマイシン / ブレオマイシン不活化酵素 / がん分子標的薬剤 / ATL発症リスク / ATL発がん機序 / がん化学予防 / 分子疫学コーホート研究 / ATL発症予防 / 国際交流 / 個別化がん予防 / ゲノム・エピゲノム解析支援 / アカデミア創薬 / 次世代分子解析技術 / ゲノムコーホート研究 / 病理形態学 / 遺伝子改変マウス / 国際研究者交流 / 若手支援 / ケミカルバイオロジー / データベース / 研究支援 / スクリーニング / 阻害剤 / 分子標的 / 化合物 / 化学療法 / オーダーメイド医療 / 放射線治療 / 免疫治療 / 抗癌剤 / 放射線療法 / 分子標的治療 / 遺伝子治療 / 免疫療法 / がんの個性診断 / 乳癌 / erbBー2 / インターロイキン2受容体 / インスリン受容体 / 細胞増殖因子 / リン酸化チロシン Less

Development of EGFR-Tyrosine Kinase Inhibitors Effective for Non-Small Cell Lung Cancer Resistant to Gefitinib
- Principal Investigator
  
  IWAO Masatomo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagasaki University
Study of inhibitors and characterization of naturally occurring spheroids from monolayer culturePrincipal Investigator
- Principal Investigator
  
  UEHARA YOSHIMASA
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Iwate Medical University
Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- Principal Investigator
  
  IMAI Kohzoh, 中村祐輔
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Development of an information-intensive basis for cancer chemotherapy
- Principal Investigator
  
  YAMORI Takao
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
Oncogenic signaling and screening of anticancer leadsPrincipal Investigator
- Principal Investigator
  
  UEHARA Yoshimasa
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Iwate Medical University
  Hirosaki Gakuin University
  National Institute of Infectious Diseases
細胞がん化のシグナル伝達の解析と抗がん剤リードの探索Principal Investigator
- Principal Investigator
  
  上原至雅
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
細胞がん化のシグナル伝達の解析と特異的阻害剤の探索Principal Investigator
- Principal Investigator
  
  上原至雅
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  National Institute of Infectious Diseases
がんの診断と治療
- Principal Investigator
  
  中村祐輔
- Project Period (FY)
  1999 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
がん増悪因子とその制御に作用する制がん物質の研究Principal Investigator
- Principal Investigator
  
  上原至雅
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
Development of methods evaluating intracellular signal transduction networks and screening of specific inhibitorsPrincipal Investigator
- Principal Investigator
  
  UEHARA Yoshimasa
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  National Institute of Health
微生物由来がん遺伝子機能抑制物質の研究Principal Investigator
- Principal Investigator
  
  上原至雅
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
微生物由来がん遺伝子機能抑制物質の研究Principal Investigator
- Principal Investigator
  
  上原至雅
- Project Period (FY)
  1990 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
微生物由来がん遺伝子機能抑制物質の研究Principal Investigator
- Principal Investigator
  
  上原至雅
- Project Period (FY)
  1990 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
発癌と細胞増殖制御におけるリン酸化チロシンタン白の役割
- Principal Investigator
  
  渡辺泰
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokai University
薬剤低感受性腫瘍克服に向けての分子生物学的解析とその臨床的方策に関する研究
- Principal Investigator
  
  山田一正
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
発癌と細胞増殖制御における燐酸化チロシン蛋白の役割
- Principal Investigator
  
  渡辺泰
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokai University
薬剤低感受性腫瘍克服に向けての分子生物学的解析とその臨床的方策に関する研究
- Principal Investigator
  
  山田一正
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
癌遺伝子産物の発現阻害と表現形態の正常化Principal Investigator
- Principal Investigator
  
  上原至雅
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  国立予防衛生研究所
腫瘍細胞の薬剤低感受性機構の解析とその克服に関する研究
- Principal Investigator
  
  山田一正
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University

[Book] 特集・制がん剤の分子標的スクリーニング成績化学療法基盤情報支援班報告-制がん候補物質のスクリーニング成績・第14報-2013
- Author(s)
  矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明.
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-221S0001
[Book] 特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第14報『癌と化学療法オンライン』2013
- Author(s)
  矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明.
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-221S0001
[Book] 特集・制がん剤の分子標的スクリーニング成績化学療法基盤支援活動報告-制がん候補物質のスクリーニング成績・第15報2013
- Author(s)
  矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-221S0001
[Book] 特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告‐制がん候補物質のスクリーニング成績・第15報『癌と化学療法オンライン』2013
- Author(s)
  矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘.
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-221S0001
[Book] 特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第13報-2010
- Author(s)
  矢守隆夫、上原至雅、吉田稔、井本正哉、清宮啓之、水上民夫、川田学、長田裕之、松浦正明、深澤秀輔
- Total Pages
  158
- Publisher
  癌と化学療法
- Data Source
  KAKENHI-PROJECT-17012025
[Book] 癌と化学療法(特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第13報-, 37)2010
- Author(s)
  矢守隆夫, 上原至雅, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明, 深澤秀輔
- Data Source
  KAKENHI-PROJECT-17012025
[Book] 「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第13報2010
- Author(s)
  矢守隆夫、上原至誠、吉田稔、井本正哉、清宮啓之、水上民夫, 他
- Total Pages
  158
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-221S0001
[Book] 足場非依存性細胞増殖測定法および併用効果評価法。「がん分子標的治療研究実践マニュアル」(日本がん分子標的治療学会編集、曽根三郎/鶴尾隆編集代表)2009
- Author(s)
  西谷直之、上原至雅
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-17016085
[Book] がん分子標的治療研究実践マニュアル(日本がん分子標的治療学会編集、曽根三郎/鶴尾隆編集代表, 足場非依存性細胞増殖測定法および併用効果評価法)2009
- Author(s)
  西谷直之, 上原至雅
- Total Pages
  340
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-17012025
[Book] がん分子標的治療研究実践マニュアル「足場非依存細胞増殖測定法および併用効果評価法」2009
- Author(s)
  西谷直之、上原至雅
- Total Pages
  329
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-17012025
[Book] 化学療法学病原微生物・がんと戦う(田中晴雄, 土屋友房編集)2009
- Author(s)
  西谷直之, 上原至雅
- Total Pages
  315
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-17012025
[Book] 文部科学省科学研究費補助金によるがん研究に係る特定領域研究 II「化学療法基盤情報支援班」報告2007
- Author(s)
  矢守隆夫, 上原至雅, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明
- Publisher
  癌と化学療法(印刷中)
- Data Source
  KAKENHI-PROJECT-17012025
[Book] 特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第12報-.2007
- Author(s)
  矢守隆夫, 上原至雅, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明.
- Publisher
  癌と化学療法
- Data Source
  KAKENHI-PROJECT-17012025
[Book] 癌と化学療法(特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第12報-, 34)2007
- Author(s)
  矢守隆夫, 上原至雅, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明
- Data Source
  KAKENHI-PROJECT-17012025
[Book] 文部科学省科学研究費補助金によるがん研究に係る特定領域研究 I「新しい戦略による抗がん剤のスクリーニングのための委員会」報告2007
- Author(s)
  矢守隆夫, 安藤俊夫, 上原至雅, 小野眞弓, 河野通明, 済木育夫, 内藤幹彦, 早川洋一, 鶴尾隆, 杉本芳一, 馬島哲夫
- Publisher
  癌と化学療法(印刷中)
- Data Source
  KAKENHI-PROJECT-17012025
[Book] 癌と化学療法(特集・制がん剤の分子標的スクリーニング成績「新しい戦略による抗がん剤のスクリーニングのための委員会」報告-制がん候補物質のスクリーニング成績・第11報-, 34)2007
- Author(s)
  矢守隆夫, 安藤俊夫, 上原至雅, 小野眞弓, 河野通明, 済木育夫, 内藤幹彦, 早川洋一, 鶴尾隆, 吉田稔, 杉本芳一, 馬島哲夫
- Data Source
  KAKENHI-PROJECT-17012025
[Book] 『シリーズ「がん研究のいま」3.がんの診断と治療』のうち「細胞がん化のシグナル伝達と新規リード探索」(分担)(中村祐輔/稲沢譲治編)2006
- Author(s)
  上原至雅, 深澤秀輔
- Total Pages
  236
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-17012025
[Book] 細胞がん化のシグナル伝達と新規リード探索。シリーズ「がん研究のいま」3. がんの診断と治療(中村祐輔/稲澤譲治編)2006
- Author(s)
  上原至雅、深澤秀輔
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-17016085
[Journal Article] Diarylpentanoid curcumin analog exhibits improved radioprotective potential in the intestinal mucosa2016
- Author(s)
  Fukuda, K, Uehara, Y, Nakata, E, Inoue, M, Shimazu, K, Yoshida, T, Kanda, H, Nanjo, H, Hosoi, Y, Yamakoshi, H, Iwabuchi, Y, Shibata, H　A
- Journal Title
  
  International Journal of Radiation Biology
  
  Volume: in press Issue: 7 Pages: 388-394
- DOI
  10.3109/09553002.2016.1164910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-16H06276
[Journal Article] Inhibition of β-catenin and STAT3 with curcumin analog suppresses gastric carcinogenesis in vivo : a novel candidate for gastric cancer treatment2015
- Author(s)
  Uehara, Y., Inoue, M., Fukuda, K., Yamakoshi, H., Hosoi, Y., Kanda, H., Oshima, M., Iwabuchi, Y., Shibata, H.
- Journal Title
  
  Gastric Cancer
  
  Volume: 18 Issue: 4 Pages: 774-783
- DOI
  10.1007/s10120-014-0434-3
- Description
  in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-24510062
[Journal Article] Autophagy regulation in the pancreatic acinar cells is independent of epidermal growth factor receptor signaling.2014
- Author(s)
  Ozaki, N., Fukuchi, Y., Tomiyoshi, S., Uehara1, H., Ida, S., Wang, J., Kimi Araki, K., Sibilia, M., Baba, H., and Yamamura, K., and Ohmuraya, M.
- Journal Title
  
  Biochem. Biophysic. Res. Comm.
  
  Volume: in press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Autophagy regulation in the pancreatic acinar cells is independent of epidermal growth factor receptor signaling.2014
- Author(s)
  Ozaki, N., Fukuchi, Y., Tomiyoshi, S., Uehara1, H., Ida, S., Wang, J., Kimi Araki, K., Sibilia, M., Baba, H., and Yamamura, K. and Ohmuraya, M.
- Journal Title
  
  Biochem. Biophysic. Res. Comm.
  
  Volume: 446 Issue: 1 Pages: 224-230
- DOI
  10.1016/j.bbrc.2014.02.111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-23310135, KAKENHI-PUBLICLY-24115712, KAKENHI-PROJECT-24591016, KAKENHI-PROJECT-25640052, KAKENHI-PROJECT-25861196, KAKENHI-PLANNED-26110003, KAKENHI-PUBLICLY-26111516, KAKENHI-PROJECT-221S0001
[Journal Article] A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway.2014
- Author(s)
  Nishiya N, Oku Y, Kumagai Y, Sato Y, Yamaguchi E, Sasaki A, Shoji M, Ohnishi Y, Okamoto H, Uehara Y.
- Journal Title
  
  Chem. Biol.
  
  Volume: 21 Issue: 4 Pages: 530-540
- DOI
  10.1016/j.chembiol.2014.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23120008, KAKENHI-PROJECT-23501310, KAKENHI-PROJECT-25460069, KAKENHI-PROJECT-221S0001
[Journal Article] Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents.,2014
- Author(s)
  Oku Y, Tareyanagi C, Takaya S, Osaka S, Ujiie H, Yoshida K, Nishiya N, Uehara Y.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 3 Pages: e92402-e92402
- DOI
  10.1371/journal.pone.0092402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501310, KAKENHI-PROJECT-25460069, KAKENHI-PROJECT-221S0001
[Journal Article] Identification of LY83583 as a specific inhibitor of Candida albicans MPS1 protein kinase.2011
- Author(s)
  Tsuda K, Nishiya N, Umeyama T and Uehara Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 409 Pages: 418-423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501310
[Journal Article] Cytotoxic and EGFR tyrosine kinase inhibitory activities of aglycone derivatives obtained by enzymatic hydrolysis of oleoside-type secoiridoid glucosides, oleuropein and ligustroside2011
- Author(s)
  Kikuchi M, Mano N, Uehara Y, Machida K, Kikuchi M
- Journal Title
  
  J Nat Med
  
  Volume: 65 (Epub 2010 Nov 2) Issue: 1 Pages: 237-240
- DOI
  10.1007/s11418-010-0476-8
- NAID
  10029460998
- Data Source
  KAKENHI-PROJECT-23501310
[Journal Article] Identification of LY83583 as a specific inhibitor of Candida albicans MPS1 protein kinas2011
- Author(s)
  Tsuda K, Nishiya N, Umeyama T, Uehara Y
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 409 Issue: 3 Pages: 418-423
- DOI
  10.1016/j.bbrc.2011.05.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780079, KAKENHI-PROJECT-23501310
[Journal Article] Cytotoxic and EGFR tyrosine kinase inhibitory activities of aglycone derivatives obtained by enzymatic hydrolysis of oleoside-type secoiridoid glucosides, oleuropein and ligustroside.2011
- Author(s)
  Kikuchi M, Mano N, Uehara Y, Machida K, Kikuchi M.
- Journal Title
  
  J Nat Med
  
  Volume: 65 Pages: 237-240
- NAID
  10029460998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501310
[Journal Article] The resorcylic acid lactone hypothemycin selectively inhibits the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cells.2010
- Author(s)
  Fukazawa H, Ikeda Y, Fukuyama M, Suzuki T, Hori H, Okuda T, Uehara Y
- Journal Title
  
  Biol Pharm Bull. 33(2)
  
  Pages: 168-73
- NAID
  130000156619
- Data Source
  KAKENHI-PROJECT-17016085
[Journal Article] The resorcylic acid lactone hypothemycin selectively inhibits the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cells2010
- Author(s)
  Fukazawa H, Ikeda Y, Fukuyama M, Suzuki T, Hori H, Okuda T, Uehara Y.
- Journal Title
  
  Biol Pharm Bull 33
  
  Pages: 168-73
- NAID
  130000156619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17012025
[Journal Article] Alkyl isothiocyanates suppress epidermal growth factor receptor kinase activity but augment tyrosine kinase activity2009
- Author(s)
  Nomura T, Uehara Y, Kawajiria H, Ryoyama K, Yamori T, Fuke Y.
- Journal Title
  
  Cancer Epidemiology 33
  
  Pages: 288-292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17012025
[Journal Article] Alkyl isothiocyanates suppress epidermal growth factor receptor kinase activity but augment tyrosine kinase activity.2009
- Author(s)
  Nomura T, UeharaY, et al. (6名中2番目)
- Journal Title
  
  Cancer Epidemiology 33
  
  Pages: 288-292
- Data Source
  KAKENHI-PROJECT-17016085
[Journal Article] Design of antiangiogenic hypoxic cell radiosensitizers: 2- Nitroimidazoles containing a 2- aminomethylene-4-cyclopentene-1, 3- dione moiety.2008
- Author(s)
  Uto Y, Uehara Y, et al. (15名中12番目)
- Journal Title
  
  Bioorganic & Medicinal Chemistry 16
  
  Pages: 6042-6053
- Data Source
  KAKENHI-PROJECT-17016085
[Journal Article] Design of antiangiogenic hypoxic cell radiosensitizers: 2-Nitroimidazoles containing a 2-aminomethylene-4-cyclopentene-1, 3-dione moiety.2008
- Author(s)
  Uto, Y. Nagasawa, H. Jin, C-Z. Nakayama, S. Tanaka, A. Kiyoi, S. Nakashima, H. Shimamura, M. Inayama, S. Fujiwara, T. Takeuchi, Y. Uehara, Y. Kirk, KL. Nakata, E. Hori, H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry 16
  
  Pages: 6042-6053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17012025
[Journal Article] Gamma-herpesviruses and cellular signaling in AIDS-associated malignancies.2007
- Author(s)
  Noguchi K, Fukazawa H, Murakami Y, Takahashi N, Yamagoe S, Uehara Y
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1288-1296
- Data Source
  KAKENHI-PROJECT-17016085
[Journal Article] Gamma-herpesviruses and cellular signaling in AIDS-associated malignancies.2007
- Author(s)
  Noguchi, K. Fukazawa, H. Murakami, Y. Takahashi, N. Yamagoe, S. and Uehara, Y.
- Journal Title
  
  Cancer science 98
  
  Pages: 1288-1296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17012025
[Journal Article] Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases.2006
- Author(s)
  Nakamura H, Sasaki Y, Uno M, Yoshikawa T, Asano T, Ban HS, Fukazawa H, Shibuya M, Uehara Y
- Journal Title
  
  Bioorg Med Chem Lett 16
  
  Pages: 5127-5131
- Data Source
  KAKENHI-PROJECT-17016085
[Journal Article] Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases2006
- Author(s)
  Nakamura H, Sasaki Y, Uno M, Yoshikawa T, Asano T, Ban HS, Fukazawa H, Shibuya M, Uehara Y.
- Journal Title
  
  Bioorg Med Chem Lett 16
  
  Pages: 5127-5131
- Data Source
  KAKENHI-PROJECT-17012025
[Journal Article] Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases. Bioorg.2006
- Author(s)
  Nakamura, H., Sasaki, Y., Uno, M., Yoshikawa, T., Asano, T., Ban, HS., Fukazawa, H., Shibuya, M., Uehara, Y.
- Journal Title
  
  Med. Chem. Lett. 16
  
  Pages: 5127-5131
- Data Source
  KAKENHI-PROJECT-17012025
[Journal Article] Modification of pyrimidine derivatives from antiviral agents to antitumor agents.2006
- Author(s)
  Kimura, H., Katoh, T., Kajimoto, T., Node, M., Hisaki, M., Sugimoto, Y., Majima, T., Uehara, Y., Yamori, T.
- Journal Title
  
  Anticancer Res. 26
  
  Pages: 91-97
- Data Source
  KAKENHI-PROJECT-17012025
[Journal Article] Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with daxx2006
- Author(s)
  Murakami Y, Yamagoe S, Noguchi K, Takebe Y, Takahashi N, Uehara Y, Fukazawa H.
- Journal Title
  
  Journal of Biological Chemistry 281
  
  Pages: 28113-28121
- Data Source
  KAKENHI-PROJECT-17012025
[Journal Article] Ets-1 dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma herpesvirus through interaction with Daxx.2006
- Author(s)
  Murakami Y, Yamagoe S, Noguchi K, Takebe Y, Takahashi N, Uehara Y, Fukazawa H
- Journal Title
  
  J Biol Chem 281
  
  Pages: 28113-28121
- Data Source
  KAKENHI-PROJECT-17016085
[Journal Article] New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.2005
- Author(s)
  Hosoya T, Uehara Y, et al. (6名中3番目)
- Journal Title
  
  Bioorg Med Chem Lett 15
  
  Pages: 2776-2780
- Data Source
  KAKENHI-PROJECT-17016085
[Journal Article] Anicemycin, a novel antitumor substance from Streptomyces thermoviolaceus TP-A0648.2005
- Author(s)
  Igarashi Y, Uehara Y, et al. (6名中5番目)
- Journal Title
  
  J Antibiotics 58
  
  Pages: 322-326
- Data Source
  KAKENHI-PROJECT-17016085
[Journal Article] New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.2005
- Author(s)
  Hosoya T, Yamamoto Y, Uehara Y, Hayashi M, Komiyama K, Ishibashi M.
- Journal Title
  
  Bioorg.Med.Chem.Lett. 15(11)
  
  Pages: 2776-2780
- Data Source
  KAKENHI-PROJECT-17012025
[Patent] Wntシグナル阻害剤2013
- Inventor(s)
  西谷直之、上原至雅
- Industrial Property Rights Holder
  西谷直之、上原至雅
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-141555
- Filing Date
  2013-07-05
- Data Source
  KAKENHI-PROJECT-23501310
[Patent] 胚の発生および／または分化を制御する方法2012
- Inventor(s)
  西谷直之　、河野富一、　畠中稔、　上原至雅
- Industrial Property Rights Holder
  西谷直之　、河野富一、　畠中稔、　上原至雅
- Industrial Property Number
  2011-041262
- Filing Date
  2012
- Data Source
  KAKENHI-PROJECT-23501310
[Patent] 胚の発生および/または分化を制御する方法2012
- Inventor(s)
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Rights Holder
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Rights Type
  特許
- Filing Date
  2012-03-13
- Overseas
- Data Source
  KAKENHI-PROJECT-23501310
[Patent] 産業財産権の名称：胚の発生および／または分化を制御する方法2012
- Inventor(s)
  西谷直之　、河野富一、　畠中稔、　上原至雅
- Industrial Property Rights Holder
  西谷直之　、河野富一、　畠中稔、　上原至雅
- Filing Date
  2012
- Overseas
- Data Source
  KAKENHI-PROJECT-23501310
[Patent] 胚の発生および/または分化を制御する方法2011
- Inventor(s)
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Rights Holder
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Number
  2011-041262
- Filing Date
  2011-02-28
- Data Source
  KAKENHI-PROJECT-221S0001
[Patent] 胚の発生および/または分化を制御する方法2011
- Inventor(s)
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Rights Holder
  西谷直之、河野富一、畠中稔、上原至雅
- Filing Date
  2011-03-13
- Overseas
- Data Source
  KAKENHI-PROJECT-221S0001
[Patent] 抗ガン作用を有する化合物、その製造方法及び抗ガン剤2004
- Inventor(s)
  上原至雅, 深澤秀輔, 古米保, 五十嵐康弘
- Industrial Property Rights Holder
  ヒューマンサイエンス振興財団
- Industrial Property Number
  2004-186572
- Filing Date
  2004-06-24
- Data Source
  KAKENHI-PROJECT-12217163
[Patent] 抗ガン作用を有する化合物、その製造方法及び抗ガン剤2004
- Inventor(s)
  上原至雅、深澤秀輔, ほか2名
- Industrial Property Rights Holder
  倉田毅:国立感染症研究所所長
- Industrial Property Number
  2004-186572
- Filing Date
  2004-06-24
- Data Source
  KAKENHI-PROJECT-17016085
[Presentation] 化学療法基盤支援活動「プロテインキナーゼ (PK) 阻害活性の評価」2014
- Author(s)
  西谷直之, 岩尾正倫, 上原至雅
- Organizer
  文科省新学術領域研究・がん支援「化学療法基盤支援活動」第３回シンポジウム　アカデミアからの抗がん剤創薬に向けて　天然物の有効利用
- Place of Presentation
  万国津梁館 (沖縄県名護市)
- Year and Date
  2014-05-12
- Invited
- Data Source
  KAKENHI-PROJECT-26293028
[Presentation] タンパク質脂質修飾酵素によるWnt/β-cateninシグナルの制御2014
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  文科省新学術領域研究・がん支援「化学療法基盤支援活動」第三回シンポジウムアカデミアからの抗がん剤創薬に向けて-天然物の有効利用
- Place of Presentation
  万国津梁館(沖縄県・名護市)
- Year and Date
  2014-05-12
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] 化学療法基盤支援活動「プロテインキナーゼ(PK)阻害活性の評価」2014
- Author(s)
  西谷直之、岩尾正倫、上原至雅
- Organizer
  文科省新学術領域研究・がん支援「化学療法基盤支援活動」第三回シンポジウムアカデミアからの抗がん剤創薬に向けて-天然物の有効利用
- Place of Presentation
  万国津梁館(沖縄県・名護市)
- Year and Date
  2014-05-12
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] Geranylgeranyltransferase inhibitors attenuate the Wnt/beta-catenin signaling pathway2013
- Author(s)
  Nishiya, N., Abe, S., Iwaoka, S., Ohmori, N., Ohnishi, Y., Sasaki, A., Shoji, M., Oku, Y, Uehara, Y.
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  矢巾
- Year and Date
  2013-04-06
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase inhibitors attenuate the Wnt/beta-catenin signaling pathway.2013
- Author(s)
  ○西谷直之、阿部早織、岩岡ささの、大森紀和、大西亨美、佐々木朱里、庄司桃子、奥裕介、上原至雅
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  岩手医科大学
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1はAurora A を活性化し、中心体の恒常性維持に寄与する2013
- Author(s)
  奥裕介、西谷直之、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2013-06-13
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin経路ケミカルサプレッサーの探索2013
- Author(s)
  ○ 西谷直之、河野富一、上原至雅
- Organizer
  日本薬学会生薬天然物部会主催・第5回食品薬学シンポジウム
- Place of Presentation
  京都大学
- Invited
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1はAurora Aを活性化し、中心体の恒常性維持に寄与する2013
- Author(s)
  ○奥　裕介、西谷直之、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] がん細胞と微小環境との相互作用の薬理学的制御2013
- Author(s)
  上原至雅、奥裕介、西谷直之
- Organizer
  日本農芸化学会2013年度大会シンポジウム「細胞骨格とシグナル伝達の理解からがんに迫る」
- Place of Presentation
  仙台
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] A phenotype-based screening for chemical suppressors of the Wnt/beta-catenin pathway in zebrafish2013
- Author(s)
  Nishiya, N., Kawano, T., and Uehara, Y.
- Organizer
  The 18th Japanese Foundation for Cancer Research-International Symposium on Cancer Chemotherapy,
- Place of Presentation
  未来館（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase as a potential molecular target for Wnt/beta-catenin pathway inhibitors2013
- Author(s)
  Nishiya N, Oku Y, Uehara Y.
- Organizer
  日本癌学会　第72回総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin経路ケミカルサプレッサーの探索2013
- Author(s)
  西谷直之, 河野富一, 上原至雅.
- Organizer
  日本薬学会生薬天然物部会主催・第5回食品薬学シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] Geranylgeranyltransferase as a potential molecular target for Wnt/beta-catenin pathway inhibitors2013
- Author(s)
  Nishiya, N., Oku, Y., Uehara, Y.
- Organizer
  日本癌学会第72回総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] がん細胞と微小環境との相互作用の薬理学的制御2013
- Author(s)
  上原至雅, 奥裕介, 西谷直之
- Organizer
  日本農芸化学会2013年度大会シンポジウム‐細胞骨格とシグナル伝達の理解からがんに迫る‐
- Place of Presentation
  仙台
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin 経路ケミカルサプレッサーの探索2013
- Author(s)
  西谷直之、河野富一、上原至雅
- Organizer
  日本薬学会生薬天然物部会主催・第5回食品薬学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2013-11-02
- Invited
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゲラニルゲラニルトランスフェラーゼ阻害剤によるβ-catenin核移行の阻害2013
- Author(s)
  ○西谷直之、奥　裕介、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゲラニルゲラニルトランスフェラーゼ阻害剤によるβ-catenin 核移行の阻害2013
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2013-06-13
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1 axis activates Aurora A and participates in centrosome integrity.2013
- Author(s)
  ○奥裕介、垂柳智秋、氏家悠貴、高谷真一、吉田健太郎、西谷直之、上原至雅
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  岩手医科大学
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] A phenotype-based screening for chemical suppressors of the Wnt/beta-catenin pathway in zebrafish2013
- Author(s)
  Nishiya, N., Kawano, T., Uehara, Y.
- Organizer
  The 18th Japanese Foundation for Cancer Research-International Symposium on Cancer Chemotherapy
- Place of Presentation
  Tokyo
- Year and Date
  2013-12-04
- Invited
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase as a potential molecular target for Wnt/beta-catenin pathway inhibitors2013
- Author(s)
  ○奥裕介、西谷直之、上原至雅
- Organizer
  日本癌学会　第72回総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Wnt/β-catenin 経路阻害活性をもつGGTI-286 の作用機序の解析2013
- Author(s)
  大森紀和、阿部早織、岩岡ささの、大西亨美、佐々木朱里、庄司桃子、奥裕介、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Rho-associated coiled coil kinase (ROCK)阻害剤による染色体不安定性の誘導2013
- Author(s)
  垂柳智秋、氏家悠貴、高谷真一、吉田健太郎、奥裕介、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1 axis activates Aurora A and participates in centrosome integrity2013
- Author(s)
  Oku, Y., Tareyanagi, C., Ujiie, H., Takaya, S., Yoshida, K., Nishiya, N., Uehara, Y.
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  矢巾
- Year and Date
  2013-04-06
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] 新規Wnt/β-cateninシグナル阻害剤IMU1003の同定2012
- Author(s)
  小松豊徳　三田地沙織　河野富一　西谷直之　上原至雅
- Organizer
  第132年会　日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] タンパク質脂質修飾による選択的Wnt/β-cateninシグナル制御2012
- Author(s)
  西谷直之, 奥裕介, 上原至雅
- Organizer
  未来医療開発プロジェクト研究成果発表会
- Place of Presentation
  岩手医科大学矢巾キャンパス
- Year and Date
  2012-08-09
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] 新規Wnt/β-catenin シグナル阻害剤IMU1003 の同定2012
- Author(s)
  小松豊徳、三田地沙織、河野富一、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] カンジダMps1 キナーゼを標的とする新規抗真菌薬の探索2012
- Author(s)
  及川慎吾、加藤大器、今野拓哉、白鳥裕佳、森岡広記、吉池比香里、奥裕介、津田香代子、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin 経路阻害剤探索系の構築2012
- Author(s)
  山口英美、熊谷裕介、佐藤佑樹、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] IMU14 derivatives as novel Wnt/beta-catenin signaling inhibitors2012
- Author(s)
  Nishiya, N., Kawano, T., Uehara、Y.
- Organizer
  日本癌学会第71回総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] カンジダMps1キナーゼを標的とする新規抗真菌薬の探索2012
- Author(s)
  及川慎吾、加藤大器、今野拓哉、白鳥裕佳、森岡広記、吉池比香里、奥裕介、津田香代子、西谷直之、上原至雅
- Organizer
  第132年会　日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin 経路阻害剤探索系の構築2012
- Author(s)
  山口英美、熊谷裕介　佐藤佑樹　西谷直之　上原至雅
- Organizer
  第132年会　日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] タンパク質の脂質修飾制御による選択的Wnt/β-catenin シグナル阻害2012
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-cateninシグナル阻害剤の探索2011
- Author(s)
  西谷直之、河野富一、津田香代子、上原至雅
- Organizer
  第15回学術集会　日本がん分子標的治療学会
- Place of Presentation
  港区台場
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin シグナル阻害剤の探索2011
- Author(s)
  西谷直之、河野富一、津田香代子、上原至雅
- Organizer
  日本がん分子標的治療学会第15回学術集会
- Place of Presentation
  東京
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゼブラフィッシュ胚を用いたがん分子標的薬探索系の開発2009
- Author(s)
  西谷直之、津田香代子、上原至雅
- Organizer
  第13回がん分子標的治療学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-17012025
[Presentation] ゼブラフィッシュ胚を用いたがん分子標的薬探索系の開発2009
- Author(s)
  西谷直之、津田香代子、上原至雅
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-17016085
[Presentation] HypothemycinによるMEK-ERK経路の選択的阻害。2008
- Author(s)
  池田好美、鈴木岳之、上原至雅、深澤秀輔
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17016085
[Presentation] 課題と展望-日本発の創薬をめざして(シンポジム1 : アカデミアから創薬パイプライン創設へ向けての新しい流れ)2008
- Author(s)
  上原至雅
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17012025
[Presentation] がん分子標的治療薬の開発現況と将来動向2008
- Author(s)
  上原至雅
- Organizer
  第67回日本癌学会学術総会レクチャーシンポジウム:がん分子標的治療におけるがん専門薬剤師の役割
- Place of Presentation
  名古屋
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-17016085
[Presentation] レクチャーシンポジウム : がん分子標的治療におけるがん専門薬剤師の役割「がん分子標的治療薬の開発現況と将来動向」2008
- Author(s)
  上原至雅
- Organizer
  菊67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-17016085
[Presentation] 課題と展望-日本発の創薬をめざして2008
- Author(s)
  上原至雅
- Organizer
  第67回日本癌学会学術総会シンポジウム1:アカデミアから創薬パイプライン創設へ向けての新しい流れ
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17016085
[Presentation] 課題と展望-日本発の創薬をめざして2008
- Author(s)
  上原至雅
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17012025
[Presentation] シンポジウム1 : アカデミアから創薬パイプライン創設へ向けての新しい流れ「課題と展望 : 日本発の創薬をめざして」2008
- Author(s)
  上原至雅
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-17016085
[Presentation] Cell-based screening approaches for identification of signal transduction inhibitors(細胞を用いたシグナル伝達阻害剤の探索)2007
- Author(s)
  深澤秀輔, 上原至雅
- Organizer
  第66回日本癌学会学術総会シンポジウム"Signal trans duction as a molecular target"
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-17012025
[Presentation] がん関連ウイルスEBVやKSHVの持続感染維持機構を標的とした分子標的薬開発のための研究2007
- Author(s)
  野口耕司、深澤秀輔、上原至雅
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-17016085
[Presentation] Cell-based screening approaches for identification of signal transduction inhibitors.2007
- Author(s)
  深澤秀輔、上原至雅
- Organizer
  第66回日本癌学会学術総会シンポジウム分子標的としてのシグナル伝達
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17016085
[Presentation] プロテインキナーゼ阻害物質の探索。2005
- Author(s)
  深澤秀輔、上原至雅
- Organizer
  文部科学省がん特定領域研究・化学療法基盤情報支援班共催シンポジウム「ケミカルゲノミクスから抗癌剤創薬への展開」
- Place of Presentation
  長浜
- Year and Date
  2005-11-04
- Data Source
  KAKENHI-PROJECT-17016085
[Presentation] IMU14 derivatives as novel Wnt/beta-catenin signaling inhibitors.
- Author(s)
  Nishiya, N., Kawano, T., Uehara、Y.
- Organizer
  日本癌学会　第71回総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] がん細胞と微小環境との相互作用の薬理学的制御
- Author(s)
  上原至雅、奥裕介、西谷直之
- Organizer
  日本農芸化学会2013年度大会シンポジウム
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Rho-associated coiled coil kinase (ROCK)阻害剤による染色体不安定性の誘導
- Author(s)
  垂柳智秋、氏家悠貴、高谷真一、吉田健太郎、奥裕介、西谷直之、上原至雅
- Organizer
  132年会日本薬学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Wnt/β-catenin経路阻害活性をもつGGTI-286の作用機序の解析
- Author(s)
  大森紀和、阿部早織、岩岡ささの、大西亨美、佐々木朱里、庄司桃子、奥裕介、西谷直之、上原至雅
- Organizer
  132年会日本薬学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] タンパク質の脂質修飾制御による選択的Wnt/β-cateninシグナル阻害
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-23501310
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UEHARA Yoshimasa 上原 至雅

UEHARA YOSHIMASA 上原 至雅

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Study of inhibitors and characterization of naturally occurring spheroids from monolayer culturePrincipal Investigator

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Oncogenic signaling and screening of anticancer leadsPrincipal Investigator

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細胞がん化のシグナル伝達の解析と抗がん剤リードの探索Principal Investigator

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細胞がん化のシグナル伝達の解析と特異的阻害剤の探索Principal Investigator

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がん増悪因子とその制御に作用する制がん物質の研究Principal Investigator

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Development of methods evaluating intracellular signal transduction networks and screening of specific inhibitorsPrincipal Investigator

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微生物由来がん遺伝子機能抑制物質の研究Principal Investigator

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微生物由来がん遺伝子機能抑制物質の研究Principal Investigator

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微生物由来がん遺伝子機能抑制物質の研究Principal Investigator

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UEHARA Yoshimasa 上原至雅

UEHARA YOSHIMASA 上原至雅

[Book] 特集・制がん剤の分子標的スクリーニング成績化学療法基盤情報支援班報告-制がん候補物質のスクリーニング成績・第14報-2013

[Book] 特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第14報『癌と化学療法オンライン』2013

[Book] 特集・制がん剤の分子標的スクリーニング成績化学療法基盤支援活動報告-制がん候補物質のスクリーニング成績・第15報2013

[Book] 特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告‐制がん候補物質のスクリーニング成績・第15報『癌と化学療法オンライン』2013

[Book] 足場非依存性細胞増殖測定法および併用効果評価法。「がん分子標的治療研究実践マニュアル」(日本がん分子標的治療学会編集、曽根三郎/鶴尾隆編集代表)2009