Tomida Akihiro 冨田章弘

… Alternative Names

TOMIDA Akihiro 冨田章弘

冨田章弘トミダアキヒロ

富田章弘トミダアキヒロ

冨田章宏トミタアキヒロ

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Researcher Number	40251483
Other IDs
Affiliation (Current)	2025: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 部長 2025: 明治薬科大学, 薬学部, 客員教授
Affiliation (based on the past Project Information) *help	2015 – 2024: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 部長 2015: 公益財団法人がん研究会, その他部局等, その他 2014 – 2015: 公益財団法人がん研究会, がん化学療法センター, 部長 2014: 公益財団法人がん研究会, がん化学療法センター, ゲノム研究部部長 2012 – 2013: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 部長 … More 2012 – 2013: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 部長 2011: 公益財団法人がん研究会, がん化学療法センター・ゲノム研究部, 部長 2010: 財団法人癌研究会, 癌化学療法センターゲノム研究部, 部長 2009: (財)癌研究会, 癌化学療法センター, 部長 2009: Japanese Foundation For Cancer Research, 癌化学療法センターゲノム研究部, 部長 2008 – 2009: Japanese Foundation For Cancer Research, 癌化学療法センター・ゲノム研究部, 部長 2007: (財)癌研究会, 癌化学療法センターゲノム研究部, 部長 2006: 癌化学療法センターゲノム研究部, 部長 2004: 東京大学, 分子細胞生物学研究所, 助教授 1993 – 2003: 東京大学, 分子細胞生物学研究所, 助手 1998: 東京大学, 分子細胞生物研究所, 助手 1996 – 1997: 東京大学, 分子生物研究所, 助手 1994 – 1995: 東京大学, 分子細胞生物研究所, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological Sciences / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Medium-sized Section 50:Oncology and related fields / Tumor biology / Clinical oncology Except Principal Investigator Tumor biology / General pharmacology
Keywords	Principal Investigator 分子標的治療 / グルコース飢餓 / 低酸素 / ストレス応答 / がん細胞 / 微小環境 / 癌 / 合成致死 / 代謝異常 / UPR … More / カンプトテシン / トポイソメラーゼ / プロテアソーム / 固形腫瘍 / 抗癌剤耐性 / 代謝 / がん化シグナル、 / がん化シグナル / 相同組換え修復 / 多様性 / キナーゼ阻害 / ISR / 代謝ストレス剤 / キナーゼ阻害剤 / 統合ストレス応答（ISR） / 代謝ストレス / グルコース / がん / PERK / 小胞体ストレス / がん微小環境 / シゲナル伝達 / 薬学 / 医療・福祉 / ゲノム / シグナル伝達 / ARNT / ゲルダナマイシンA / HIF-1α / p53 / アポトーシス / ユビキチン / Unfolded Protein Response / Cullin / CSN5 / Jab1 / 固形がん / 抗がん剤耐性 / エトポシド / プロテアソーム阻害剤 / 耐性 / 抗がん剤 / ストレス / 核内蓄積 / グルコース調節ストレス応答 … More Except Principal Investigator アポトーシス / 耐性克服 / 抗癌剤耐性 / マイクロアレイ / DNAトポイソメラーゼ / p-糖蛋白 / 抗がん剤 / ラジカルスカベンジャー / ADF / 癌転移 / 分子標的 / 耐性遺伝子 / 耐性タンパク / P-糖タンパク / UPR / オートファジー / ミトコンドリア / グルコース飢餓 / 小胞体ストレス応答 / がん微小環境 / がん分子標的薬剤 / ATL発症リスク / ATL発がん機序 / がん化学予防 / 分子疫学コーホート研究 / ATL発症予防 / 国際交流 / 個別化がん予防 / ゲノム・エピゲノム解析支援 / アカデミア創薬 / 次世代分子解析技術 / ゲノムコーホート研究 / 病理形態学 / 遺伝子改変マウス / 国際研究者交流 / 若手支援 / 小胞体ストレス / 分子標的薬 / 癌 / 創薬 / グルタチオン / ABCスーパーファミリー / MRP / 抗がん剤耐性 / オンコプロテイン-18 / DNAメチル化 / 多剤耐性 / 抗癌剤感受性 / ABCトランスポーター・スーパーファミリー / 細胞内分子標的 / トポイソメラーゼII / CMOAT / MRPファミリー蛋白 / P-糖蛋白質 / MDRI 遺伝子 / シスプラチン耐性 / ABCカッセトファミリー / 薬剤耐性 / 耐性 / 抗癌剤 / チオレドキシン / 癌移転 / チオレオキシン / ユビキチン / カルシウム拮抗剤 / モノクローナル抗体 Less

合成致死性を司る代謝リプログラミング機構の解明と治療への応用Principal Investigator
- Principal Investigator
  
  冨田章弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Elucidation of the molecular basis of cancer-specific, metabolic stress response mechanisms and application to drug discoveryPrincipal Investigator
- Principal Investigator
  
  TOMIDA Akihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Molecular basis for synthetic lethality focusing on glucose metabolism and homologous recombination repair in cancer cellsPrincipal Investigator
- Principal Investigator
  
  TOMIDA Akihiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Japanese Foundation for Cancer Research
Elucidation of molecular basis of diversity in metabolic stress response of cancer cells for drug discoveryPrincipal Investigator
- Principal Investigator
  
  TOMIDA Akihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Japanese Foundation for Cancer Research
Elucidation of cooperative mechanisms between energy metabolism and stress response of cancer cells for drug discoveryPrincipal Investigator
- Principal Investigator
  
  Tomida Akihiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Japanese Foundation for Cancer Research
Identification and characterization of mitochondrial regulators modulating the unfolded protein response
- Principal Investigator
  
  KUNIMASA KAZUHIRO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research
Elucidation of the role of PERK signaling pathway in tumor microenvironment and its application for drug discoveryPrincipal Investigator
- Principal Investigator
  
  TOMIDA Akihiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research
Adaptive mechanisms of cancer cells to unique growth microenvironment and therapeutic targetingPrincipal Investigator
- Principal Investigator
  
  TOMIDA Akihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Japanese Foundation For Cancer Research
Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- Principal Investigator
  
  IMAI Kohzoh, 中村祐輔
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
In silico screening and characterization of modulators of the unfolded protein response (UPR)
- Principal Investigator
  
  SAITO Sakae
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Japanese Foundation For Cancer Research
Molecular therapeutics targeting drug-resistance mechanismsPrincipal Investigator
- Principal Investigator
  
  TOMIDA Akihiro, 鶴尾隆
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
  The University of Tokyo
プロテアソーム蛋白分解系を標的としたストレス誘導性薬剤耐性の克服Principal Investigator
- Principal Investigator
  
  冨田章弘
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
低酸素によって誘導されるアポトーシスの制御機構Principal Investigator
- Principal Investigator
  
  冨田章弘
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
プロテアソーム蛋白分解系を標的とした固形がんの抗がん剤耐性克服法の開発Principal Investigator
- Principal Investigator
  
  冨田章弘
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
ストレスによるプロテアソーム核内蓄積の機序解析Principal Investigator
- Principal Investigator
  
  冨田章弘 (富田章弘)
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
抗がん剤感受性を制御する細胞内分子標的の発現と機能
- Principal Investigator
  
  桑野信彦
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
腫瘍でのADF/チオレドキシンの活性化機構並びに抗癌剤の影響と作用機序の解析
- Principal Investigator
  
  淀井淳司
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
臨床応用可能な抗がん剤耐性マーカーの探索とその克服
- Principal Investigator
  
  桑野信彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
グルコース調節ストレスによって誘導される抗癌剤耐性の分子機序Principal Investigator
- Principal Investigator
  
  冨田章弘
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
腫瘍でのADF/チオレドキシンの活性化機構並びに抗癌剤の影響の作用機序の解析
- Principal Investigator
  
  淀井淳司
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
がん細胞の薬剤感受性と抵抗性の分子機構とその制御
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1994 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
グルコース調整ストレス応答の抗癌剤耐性への関与Principal Investigator
- Principal Investigator
  
  冨田章弘
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
難治性癌の薬剤抵抗性の分子機構とその克服
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo

[Book] 特集・制がん剤の分子標的スクリーニング成績化学療法基盤支援活動報告-制がん候補物質のスクリーニング成績・第15報2013
- Author(s)
  矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-221S0001
[Book] 特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告‐制がん候補物質のスクリーニング成績・第15報『癌と化学療法オンライン』2013
- Author(s)
  矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘.
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-221S0001
[Book] 新臨床腫瘍学、1-5細胞死2012
- Author(s)
  冨田章弘(日本臨床腫瘍学会編集)
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-22300342
[Book] がん増殖と悪性化の分子機構、19章がんの化学療法と抗がん剤耐性2012
- Author(s)
  冨田章弘(宮澤恵二・伊東進編)
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-22300342
[Book] がんの分子標的と治療薬、6章細胞周期・アポトーシス・ネクローシス2010
- Author(s)
  冨田章弘(西尾和人、西条長宏編)
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22300342
[Book] マイクロアレイを用いた遺伝子発現解析2009
- Author(s)
  齋藤さかえ, 冨田章弘
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] Activating mutations in EGFR and PI3K promote ATF4 induction for NSCLC cell survival during amino acid deprivation2023
- Author(s)
  Mizuki Takahashi, Yuka Okamoto, Yu Kato, Hitomi Shirahama, Satomi Tsukahara, Yoshikazu, Sugimoto, Akihiro Tomida
- Journal Title
  
  Heliyon
  
  Volume: Vol.9 Issue: 4 Pages: e14799-e14799
- DOI
  10.1016/j.heliyon.2023.e14799
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07689, KAKENHI-PROJECT-23K24193
[Journal Article] Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation2022
- Author(s)
  Kunimasa Kazuhiro、Ikeda-Ishikawa Chika、Tani Yuri、Tsukahara Satomi、Sakurai Junko、Okamoto Yuka、Koido Masaru、Dan Shingo、Tomida Akihiro
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 11533-11533
- DOI
  10.1038/s41598-022-15673-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07312, KAKENHI-PROJECT-23K24193
[Journal Article] Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor2021
- Author(s)
  Nishiya Naoyuki、Oku Yusuke、Ishikawa Chie、Fukuda Tsutomu、Dan Shingo、Mashima Tetsuo、Ushijima Masaru、Furukawa Yoko、Sasaki Yuka、Otsu Keishi、Sakyo Tomoko、Abe Masanori、Yonezawa Honami、Ishibashi Fumito、Matsuura Masaaki、Tomida Akihiro、Seimiya Hiroyuki、Yamori Takao、Iwao Masatomo、Uehara Yoshimasa
- Journal Title
  
  Cancer Science
  
  Volume: － Issue: 5 Pages: 1963-1974
- DOI
  10.1111/cas.14839
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05715, KAKENHI-PUBLICLY-20H04789, KAKENHI-PROJECT-18K09526, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K21555, KAKENHI-PROJECT-19H01806, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-19H03526, KAKENHI-PROJECT-21K07251
[Journal Article] eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma.2021
- Author(s)
  Iwao Y, Okamoto Y, Shirahama H, Tsukahara S, Tomida A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 573 Pages: 93-99
- DOI
  10.1016/j.bbrc.2021.08.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03526
[Journal Article] The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.2020
- Author(s)
  Okamoto Y, Saito T, Tani Y, Toki T, Hasebe A, Koido M, Tomida A.
- Journal Title
  
  J Biol Chem
  
  Volume: 295 Issue: 14 Pages: 4591-4603
- DOI
  10.1074/jbc.ra119.010655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03526, KAKENHI-PROJECT-18K15293
[Journal Article] Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy2020
- Author(s)
  Nagasawa Ikuko、Koido Masaru、Tani Yuri、Tsukahara Satomi、Kunimasa Kazuhiro、Tomida Akihiro
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 4 Pages: 101028-101028
- DOI
  10.1016/j.isci.2020.101028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07309, KAKENHI-PROJECT-19H03526, KAKENHI-PROJECT-18K19486
[Journal Article] GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress2020
- Author(s)
  Kato Yu、Kunimasa Kazuhiro、Takahashi Mizuki、Harada Ayaka、Nagasawa Ikuko、Osawa Masanori、Sugimoto Yoshikazu、Tomida Akihiro
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 98 Issue: 6 Pages: 669-676
- DOI
  10.1124/molpharm.120.000070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16339, KAKENHI-PUBLICLY-19H04973, KAKENHI-PROJECT-19H03526, KAKENHI-PROJECT-18K07302, KAKENHI-PROJECT-18K07309, KAKENHI-PROJECT-18K19486
[Journal Article] BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.2018
- Author(s)
  Kato Y, Kunimasa K, Sugimoto Y, Tomida A.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 504 Issue: 4 Pages: 721-726
- DOI
  10.1016/j.bbrc.2018.09.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07302, KAKENHI-PROJECT-18K07309, KAKENHI-PROJECT-16H04717
[Journal Article] InDePTH: detection of hub genes for developing gene expression networks under anticancer drug treatment.2018
- Author(s)
  Koido M, Tani Y, Tsukahara S, Okamoto Y, Tomida A
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 49 Pages: 29097-29111
- DOI
  10.18632/oncotarget.25624
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04717
[Journal Article] Mitochondrial deficiency impairs hypoxic induction of HIF-1 transcriptional activity and retards tumor growth.2017
- Author(s)
  Koido M, Haga N, Furuno A, Tsukahara S, Sakurai J, Tani Y, Sato S, Tomida A.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 7 Pages: 11841-11854
- DOI
  10.18632/oncotarget.14415
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04717
[Journal Article] BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib.2017
- Author(s)
  Nagasawa I, Kunimasa K, Tsukahara S, Tomida A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 482 Issue: 4 Pages: 1491-1497
- DOI
  10.1016/j.bbrc.2016.12.062
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04717, KAKENHI-PROJECT-16J10435
[Journal Article] PMEPA1, a TGF-β- and hypoxia-inducible gene that participates in hypoxic gene expression networks in solid tumors.2016
- Author(s)
  Koido M, Sakurai J, Tsukahara S, Tani Y, Tomida A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 479 Issue: 4 Pages: 615-621
- DOI
  10.1016/j.bbrc.2016.09.166
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04717
[Journal Article] The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.2015
- Author(s)
  Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 10；462（4） Issue: 4 Pages: 383-388
- DOI
  10.1016/j.bbrc.2015.04.144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25290061
[Journal Article] Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation2015
- Author(s)
  Mashima T, Ushijima M, Matsuura M, Tsukahara S, Kunimasa K, Furuno A, Saito S, Kitamura M, Soma-Nagae T, Seimiya H, Dan S, Yamori T, Tomida A
- Journal Title
  
  Cancer Science
  
  Volume: in press Issue: 7 Pages: 909-920
- DOI
  10.1111/cas.12682
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430120, KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-26640109, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25290061
[Journal Article] TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.2015
- Author(s)
  Tsukumo Y, Tsukahara S, Furuno A, Iemura SI, Natsume T, Tomida A
- Journal Title
  
  Journal of Cellular Biochemistry
  
  Volume: 117(2): Issue: 2 Pages: 500-9
- DOI
  10.1002/jcb.25301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25290061
[Journal Article] Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells.2014
- Author(s)
  5.Migita T, Okabe S, Ikeda K, Igarashi S, Sugawara S, Tomida A, Soga T, Taguchi R, Seimiya H.
- Journal Title
  
  Int J Cancer.
  
  Volume: 135 Issue: 1 Pages: 37-47
- DOI
  10.1002/ijc.28652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24619007, KAKENHI-PROJECT-24650626, KAKENHI-PROJECT-24650639, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25290061, KAKENHI-PROJECT-221S0001
[Journal Article] Ultrastructural localization of intravenously injected carbon nanohorns in tumor.2014
- Author(s)
  Matsumura S, Yuge R, Sato S, Tomida A, Ichihashi T, Irie H, Iijima S, Shiba K, Yudasaka M.
- Journal Title
  
  Int J Nanomedicine
  
  Volume: 9 Pages: 3499-3508
- DOI
  10.2147/ijn.s62688
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24650626, KAKENHI-PROJECT-25290061
[Journal Article] TBL2 is a novelPERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.2014
- Author(s)
  Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A
- Journal Title
  
  PLOS ONE
  
  Volume: 13:9(11) Issue: 11 Pages: e112761-e112761
- DOI
  10.1371/journal.pone.0112761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-24650626, KAKENHI-PROJECT-25290061
[Journal Article] Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact2013
- Author(s)
  Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H.
- Journal Title
  
  Am J Pathol.
  
  Volume: 182 Issue: 5 Pages: 1800-1810
- DOI
  10.1016/j.ajpath.2013.01.048
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134007, KAKENHI-PROJECT-22300341, KAKENHI-PROJECT-24619007, KAKENHI-PROJECT-24650626, KAKENHI-PROJECT-24650639, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25290061, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-23117527
[Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds.2013
- Author(s)
  Ushijima M, Mashima T, Tomida A, Dan S, Saito S, Furuno A, Tsukahara S, Seimiya H, Yamori T, Matsuura M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104(3) Issue: 3 Pages: 360-368
- DOI
  10.1111/cas.12071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240092, KAKENHI-PROJECT-22300341, KAKENHI-PROJECT-23501319, KAKENHI-PROJECT-23701067, KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-24650626, KAKENHI-PROJECT-24650639, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25290061, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-23117527
[Journal Article] Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling2012
- Author(s)
  Saito S, Furuno A, Sakurai J, Park HR, Shin-ya K, Tomida A
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 9 Pages: e45845-e45845
- DOI
  10.1371/journal.pone.0045845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300342, KAKENHI-PROJECT-23701067, KAKENHI-PROJECT-24650626
[Journal Article] Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-in duced cyto toxicity during glucose deprivation2012
- Author(s)
  Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, Kondo H, Ushijima M, Matsuura M, Watanabe T, Tomida A
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 11(5) Issue: 5 Pages: 1082-1091
- DOI
  10.1158/1535-7163.mct-11-0871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300109, KAKENHI-PROJECT-22300342, KAKENHI-PROJECT-22700892, KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-24650626
[Journal Article] Use of chemical genomics in assessment of the UPR2011
- Author(s)
  Saito S, Tomida A
- Journal Title
  
  Methods Enzymol
  
  Volume: 491 Pages: 327-41
- DOI
  10.1016/b978-0-12-385928-0.00018-3
- ISBN
  9780123859280
- Data Source
  KAKENHI-PROJECT-22300342
[Journal Article] Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions2010
- Author(s)
  Naomi Haga, Sakae Saito, Yoshinori Tsukumo, Junko Sakurai, Aki Furuno, Takashi Tsuruo, Akohiro Tomida
- Journal Title
  
  Cancer Science Vol.101,No.5
  
  Pages: 1125-1132
- NAID
  10026591912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity2010
- Author(s)
  Kim JY, Hwang JH, Cha MR, Yoon MY, Son ES, Tomida A, Ko B, Song SW, Shin-ya K, Hwang YI, Park HR
- Journal Title
  
  J Cell Physiol
  
  Volume: 224 Issue: 1 Pages: 33-40
- DOI
  10.1002/jcp.22085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300342
[Journal Article] Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions2010
- Author(s)
  Haga N, Saito S, Tsukumo Y, Sakurai J, Furuno A, Tsuruo T, Tomida A
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Issue: 5 Pages: 1125-32
- DOI
  10.1111/j.1349-7006.2010.01525.x
- NAID
  10026591912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300342
[Journal Article] Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin2009
- Author(s)
  Matsuo J, Tsukumo Y, Sakurai J, Tsukahara S, Park HR, Shin-Ya K, Watanabe T, Tsuruo T, Tomida A.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 327-33
- NAID
  10025142654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site2009
- Author(s)
  Yoshinori Tsukumo, Satomi Tsukahara, Sakae Saito, Takashi Tsuruo, Akihiro Tomida
- Journal Title
  
  J Biol Chem. Vol.284,No.40
  
  Pages: 27500-27510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation2009
- Author(s)
  Saito S, Furuno A, Sakurai J, Sakamoto A, Park HR, Shin-Ya K, Tsuruo T, Tomida A.
- Journal Title
  
  Cancer Res. 69
  
  Pages: 4225-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] 小胞体ストレス応答を標的とした癌治療2009
- Author(s)
  齋藤さかえ, 冨田章弘
- Journal Title
  
  実験医学 27巻,2号
  
  Pages: 298-304
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation2009
- Author(s)
  Sakae Saito, Aki Furuno, Junko Sakurai, Asami Sakamoto, Hae-Ryong Park, Kazuo Shin-ya, Takashi Tsuruo, Akihiro Tomida
- Journal Title
  
  Cancer Research Vol.69,No.10
  
  Pages: 4225-4234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] がんにおける小胞体ストレス-UPRを標的とした抗がん剤の開発2009
- Author(s)
  齋藤さかえ, 冨田章弘
- Journal Title
  
  最新医学 64巻
  
  Pages: 242-250
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site2009
- Author(s)
  Tsukumo Y, Tsukahara S, Saito S, Tsuruo T, Tomida A.
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 27500-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Journal Article] 小胞体ストレスとがん治療2008
- Author(s)
  齋藤さかえ, 冨田章弘
- Journal Title
  
  Cancer Frontier 10巻
  
  Pages: 26-31
- NAID
  40016270403
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation2007
- Author(s)
  Tsukumo Y, Tomida A, Kitahara O, Nakamura Y, Asada S, Mori K, Tsuruo T.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 29264-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] BRAF V600E変異型メラノーマ細胞におけるシスチン代謝変化とフェロトーシス抵抗性の解析2023
- Author(s)
  野田智幹，白濱仁深，冨田章弘．
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24193
[Presentation] Involvement of alpha-ketoglutarate depletion in cisplatin sensitization induced by glutaminolysis inhibition.2023
- Author(s)
  岡本有加，冨田章弘．
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24193
[Presentation] オミクスデータに基づく細胞密度依存的なフェロトーシス抵抗性の解析2022
- Author(s)
  白濱仁深，冨田章弘．
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24193
[Presentation] PI3K-mTOR経路による統合的ストレス応答制御機構の解析2022
- Author(s)
  髙橋瑞希，加藤優，國政和弘，杉本芳一，冨田章弘．
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] がん代謝の阻害によるシスプラチン高感受性化における統合ストレス応答の関与2022
- Author(s)
  岡本有加，冨田章弘．
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24193
[Presentation] Analysis of the regulatory mechanisms of ATF4 expression by the PI3K-mTOR pathway in lung cancer cell lines.2022
- Author(s)
  髙橋瑞希，加藤優，岡本有加，杉本芳一，冨田章弘．
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24193
[Presentation] Omics analyses on density-dependent ferroptosis resistance in melanoma cells.2022
- Author(s)
  白濱仁深，冨田章弘．
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24193
[Presentation] 翻訳開始因子を介したストレス応答転写因子ATF4の新たな制御機構の解明2021
- Author(s)
  岩男行恵，冨田章弘．
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] がん治療の標的分子に認められる3つの条件2021
- Author(s)
  冨田章弘．
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] Functional mitochondria play an essential role in tumor growth of pancreatic cancer cells.2021
- Author(s)
  国政和宏，塚原里美，冨田章弘．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] Possible involvement of calcium homeostasis in density-dependent ferroptosis resistance.2021
- Author(s)
  白濱仁深，旦慎吾，冨田章弘．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] 肺がん細胞株において相同組換え修復不全を誘導する代謝阻害剤の探索・同定2021
- Author(s)
  岡本有加，冨田章弘．
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] GZD824のGCN2-ATF4ストレス応答経路に対する阻害効果2020
- Author(s)
  高橋瑞希，加藤優，國政和宏，杉本芳一，冨田章弘
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19486
[Presentation] 肺がん細胞株におけるシスプラチン感受性を増強する代謝阻害剤2020
- Author(s)
  岡本有加，冨田章弘
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] 新規UPR阻害剤ムブリチニブのミトコンドリア呼吸鎖阻害作用2020
- Author(s)
  国政和宏，塚原里美，冨田章弘
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] 肺がん細胞株におけるシスプラチン感受性を増強する代謝阻害剤2020
- Author(s)
  岡本有加，冨田章弘
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K19486
[Presentation] メラノーマ細胞における細胞密度依存的なフェロトーシス誘導の性状解析2020
- Author(s)
  白濱仁深，旦慎吾，冨田章弘
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] 新規UPR阻害剤ムブリチニブのミトコンドリア呼吸鎖阻害作用2020
- Author(s)
  国政和宏，塚原里美，冨田章弘
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K19486
[Presentation] GZD824のGCN2-ATF4ストレス応答経路に対する阻害効果2020
- Author(s)
  高橋瑞希，加藤優，國政和宏，杉本芳一，冨田章弘
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] メラノーマ細胞における細胞密度依存的なフェロトーシス誘導の性状解析2020
- Author(s)
  白濱仁深，旦慎吾，冨田章弘
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19486
[Presentation] 低細胞密度のメラノーマ細胞におけるフェロトーシス誘導2019
- Author(s)
  白濱仁深，旦慎吾，冨田章弘
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] Involvement of PERK in LGR5 depletion under endoplasmic reticulum stress conditions.2019
- Author(s)
  Okamoto Y, Koido M, Tomida A.
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Precision Medicine
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] BRAF活性化変異メラノーマ胞におけるGPX4依存性形質の出現機序の解析2019
- Author(s)
  白濱仁深，冨田章弘
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] 癌遺伝子BCR-ABLによる統合的ストレス応答制御機構2019
- Author(s)
  加藤優，國政和宏，杉本芳一，冨田章弘
- Organizer
  第139年会日本薬学会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] ムブリチニブのミトコンドリア呼吸阻害作用2019
- Author(s)
  国政和宏，冨田章弘
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] 解糖系阻害剤2DGによるcisplatin高感受性化へのDNA 2本鎖切断の蓄積の関与2019
- Author(s)
  岡本有加，冨田章弘
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19486
[Presentation] 新規UPR阻害剤mubritinibのミトコンドリア機能阻害作用2019
- Author(s)
  国政和宏，冨田章弘
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] 2-デオキシグルコースによるシスプラチン高感受性化におけるDNA 相同組換え修復欠損の関与2019
- Author(s)
  岡本有加，冨田章弘
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K19486
[Presentation] 2-デオキシグルコースによるシスプラチン高感受性化におけるDNA 相同組換え修復欠損の関与2019
- Author(s)
  岡本有加，冨田章弘
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] 解糖系阻害剤2DGによるcisplatin高感受性化へのDNA 2本鎖切断の蓄積の関与2019
- Author(s)
  岡本有加，冨田章弘
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03526
[Presentation] ミトコンドリア機能はグルコース飢餓下での膵がん細胞の生存に必須である2018
- Author(s)
  国政和宏，塚原里美，冨田章弘．
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] 膵がん細胞株におけるグルコース飢餓下でのミトコンドリア機能の重要性2018
- Author(s)
  国政和宏，冨田章弘．
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.2018
- Author(s)
  Kato Y, Kunimasa K, Sugimoto Y, Tomida, A.
- Organizer
  The 23rd Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] BCR-ABLはERストレス下におけるPERK-ATF4経路の活性化および細胞生存を制御する2018
- Author(s)
  加藤優，杉本芳一，冨田章弘．
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] アミノ酸飢餓により引き起こされるIntegrated Stress Response選択的な阻害剤の性状解析2018
- Author(s)
  加藤優，杉本芳一，冨田章弘．
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] 解糖系阻害剤2-Deoxy-D-glucoseによるシスプラチン高感受性化2018
- Author(s)
  岡本有加，小井土大，冨田章弘
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] ミトコンドリア機能はグルコース飢餓下での膵がん細胞の生存に必須である2018
- Author(s)
  国政和宏，塚原里美，冨田章弘．
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K19486
[Presentation] Integrated Stress Response におけるGCN2経路選択的な阻害剤の探索2018
- Author(s)
  加藤優，杉本芳一，冨田章弘．
- Organizer
  第138年会日本薬学会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] PERKによる小胞体ストレス下におけるLGR5不良タンパク質蓄積の防止2018
- Author(s)
  岡本有加，冨田章弘．
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] Her2阻害剤mubritinibのグルコース飢餓選択的な殺細胞効果2017
- Author(s)
  国政和宏，塚原里美，冨田章弘．
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] 抗がん剤作用において影響力のある遺伝子を推定するための遺伝子発現データの統合解析アルゴリズム2017
- Author(s)
  小井土大，岡本有加，冨田章弘．
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] Mubritinibのグルコース飢餓選択的な殺細胞効果2017
- Author(s)
  国政和宏，竹居修平，冨田章弘．
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] 小胞体ストレス下のおけるPERK活性依存的なLGR5生合成経路の制御2017
- Author(s)
  岡本有加，小井土大，冨田章弘．
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] Integrated stress response における経路特異的阻害剤の探索とその性状解析2017
- Author(s)
  加藤優，国政和宏，永澤生久子，杉本芳一，冨田章弘．
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] メリンジョ種子抽出物と主要成分gnetin Cの抗がん作用2016
- Author(s)
  国政和宏，冨田章弘．
- Organizer
  日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] がん幹細胞マーカー分子LGR5の代謝ストレス下での発現制御におけるPERKの関与2016
- Author(s)
  岡本有加，小井土大，永澤生久子，冨田章弘．
- Organizer
  日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] 小胞体ストレス下におけるがん幹細胞マーカー分子LGR5の発現制御に対するPERKの関与2016
- Author(s)
  岡本有加，永澤生久子，冨田章弘．
- Organizer
  日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] BRAF阻害剤誘導性ストレス適応応答シグナルを標的とした選択的阻害剤の探索2016
- Author(s)
  永澤生久子，国政和宏，冨田章弘．
- Organizer
  日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H04717
[Presentation] Selective cancer cell killing by spautin-1, a USP10/USP13 inhibitor, under glucose starvation2016
- Author(s)
  Kazuhiro Kunimasa, Masaru Koido, Chika Ikeda, Satomi Tsukahara, Junko Sakurai, Shingo Dan, Takao Yamori, Akihiro Tomida
- Organizer
  AACR-JCA 10th Joint Conference
- Place of Presentation
  Maui, Hawaii, USA
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430120
[Presentation] USP10/USP13阻害剤Spautin-1の小胞体ストレス応答抑制作用分子機序の解析2015
- Author(s)
  国政和宏，旦慎吾，矢守隆夫，冨田章弘．
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] がん細胞増殖を抑制するマイクロRNA阻害剤による異常なDNA損傷応答2015
- Author(s)
  岡本有加，小井土大，塚原里美，冨田章弘．
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] Inhibitory mechanisms of spautin-1, an USP10/USP13 inhibitor, on unfolded protein response2015
- Author(s)
  国政和宏、旦慎吾，矢守隆夫，冨田章弘
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25430120
[Presentation] がん分子標的薬に関する包括的遺伝子発現データベース構築2015
- Author(s)
  馬島哲夫，牛嶋大，松浦正明，塚原里美，国政和宏，清宮啓之，旦慎吾，矢守隆夫，冨田章弘．
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] がん細胞増殖抑制活性を有するmiRNA阻害剤によるDNA損傷応答の誘導2015
- Author(s)
  岡本有加，冨田章弘．
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] 小胞体ストレス下における幹細胞マーカー分子LGR5及びCD44の発現変動2015
- Author(s)
  土岐珠未，岡本有加，永澤生久子，冨田章弘．
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] がん分子標的薬の標的分子経路の評価と同定のための包括的遺伝子発現データベース構築と解析2015
- Author(s)
  馬島哲夫，冨田章弘，国政和宏，旦慎吾，清宮啓之，矢守隆夫．
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] Selective cancer cell killing by spautin-1, a USP10/USP13 inhibitor, under glucose starvation2015
- Author(s)
  国政和宏、旦慎吾，矢守隆夫，冨田章弘
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25430120
[Presentation] USP10/USP13阻害剤Spautin-1のグルコース選択的な殺細胞効果2015
- Author(s)
  国政和宏，旦慎吾，矢守隆夫，冨田章弘．
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] 嫌気的環境下においてミトコンドリアを介して活性化するHIF-1の新たな転写活性制御機構2014
- Author(s)
  小井土大，芳賀直実，塚原里美，佐藤重男，冨田章弘．
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] オートファジー阻害剤spautin-1はグルコース飢餓誘導性の小胞体ストレス応答を抑制する2014
- Author(s)
  国政和宏，冨田章弘．
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台市情報・産業プラザ（宮城県仙台市）
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] Connectivity Mapデータベースを利用した化合物スクリーニングのアルゴリズム開発2014
- Author(s)
  牛嶋大，冨田章弘，齋藤さかえ，野田哲生，松浦正明
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] オートファジー阻害剤spautin-1のグルコース飢餓選択的な殺細胞作用2014
- Author(s)
  国政和宏，冨田章弘．
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-24650626
[Presentation] Connectivity mapデータベースを利用した化合物スクリーニングのアルゴリズム開発2014
- Author(s)
  牛嶋大、冨田章弘、斎藤さかえ、野田哲生、松浦正明
- Organizer
  文科省新学術領域研究・がん支援「化学療法基盤支援活動」第三回シンポジウムアカデミアからの抗がん剤創薬に向けて―天然物の有効利用
- Place of Presentation
  万国津梁館(沖縄県・名護市)
- Year and Date
  2014-05-12
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] がん細胞増殖抑制効果を有するヒトmicroRNA阻害剤の探索2014
- Author(s)
  岡本有加，国政和宏，冨田章弘．
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台市情報・産業プラザ（宮城県仙台市）
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-24650626
[Presentation] がん細胞増殖抑制効果を有するヒトmicroRNA阻害剤の探索2014
- Author(s)
  岡本有加，国政和宏，冨田章弘．
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台市情報・産業プラザ（宮城県仙台市）
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] 嫌気的環境下においてミトコンドリアを介して活性化するHIF-1の新たな転写活性制御機構2014
- Author(s)
  小井土大，芳賀直実，塚原里美，佐藤重男，冨田章弘．
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-24650626
[Presentation] UPR標的遺伝子の発現変化を伴って細胞毒性を示すmiRNA阻害剤の同定2014
- Author(s)
  岡本有加，小井土大，塚原里美，国政和宏，冨田章弘．
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-24650626
[Presentation] オートファジー阻害剤spautin-1のグルコース飢餓選択的な殺細胞作用2014
- Author(s)
  国政和宏，冨田章弘．
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] UPR標的遺伝子の発現変化を伴って細胞毒性を示すmiRNA阻害剤の同定2014
- Author(s)
  岡本有加，小井土大，塚原里美，国政和宏，冨田章弘．
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] オートファジー阻害剤spautin-1はグルコース飢餓誘導性の小胞体ストレス応答を抑制する2014
- Author(s)
  国政和宏，冨田章弘．
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台市情報・産業プラザ（宮城県仙台市）
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-24650626
[Presentation] Constitutive activation of hypoxic response in newly established mtDNA-deficient-cell line with highly tumorigenesis.2013
- Author(s)
  Akihiro Tomida
- Organizer
  9th AACR-Japanese Cancer Association Joint Conferenc
- Place of Presentation
  Maui
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] グルコース飢餓環境下における小胞体ストレス応答(UPR)制御薬剤の作用機序の解析2011
- Author(s)
  冨田章弘
- Organizer
  日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテル日航東京(東京)
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] ビグアナイド系化合物による4E-BP1の活性化と抗腫瘍効果2011
- Author(s)
  冨田章弘
- Organizer
  日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテル日航東京(東京)
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] Dorsomorphinはグルコース飢餓により誘導される小胞体ストレス応答を阻害する2011
- Author(s)
  冨田章弘
- Organizer
  日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] 新規in situハイブリダイゼーション技術によるmRNA発現の判定量的解析2011
- Author(s)
  冨田章弘
- Organizer
  日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] グルコース飢餓状態での細胞死誘導2010
- Author(s)
  冨田章弘
- Organizer
  日本CellDeath学会
- Place of Presentation
  名古屋
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] Unfolded protein response as a therapeutic target in tumor microenvironment2010
- Author(s)
  Tomida, A
- Organizer
  The 15th Japan ? Korea Cancer Research Workshop 2010
- Place of Presentation
  (Incheon, Korea)
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] がん微小環境標的治療法の開発を目指したがん細胞のグルコース飢餓への新たな適応機構の解析2010
- Author(s)
  冨田章弘、小井土大、芳賀直実、塚原里美、佐藤重男
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] がん細胞の環境応答としてのUPRとその治療標的化2010
- Author(s)
  冨田章弘
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  (大阪)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] がん細胞の環境応答としてのUPRとその治療標的化2010
- Author(s)
  冨田章弘
- Organizer
  日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] がんの特徴的代謝からみたERストレス2009
- Author(s)
  冨田章弘
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] Tumor metabolism and ER stress2009
- Author(s)
  冨田章弘
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] ミトコンドリアはグルコース飢餓環境下のがん細胞の生存を制御する2009
- Author(s)
  芳賀直実, 齋藤さかえ, 鶴尾隆, 築茂由則, 冨田章弘
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] Unfolded protein response in tumor microenvironment2009
- Author(s)
  冨田章弘
- Organizer
  The 14th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
- Place of Presentation
  東京
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] がん分子標的治療のバイオマーカー探索技術の動向2009
- Author(s)
  冨田章弘
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] Therapeutic approach exploiting physiological ER stress against solid tumors,2008
- Author(s)
  冨田章弘
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] UPR inhibition as a microenvironment-oriented therapeutic approach.2007
- Author(s)
  冨田章弘
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-17016012
[Presentation] Spautin-1, an autophagy inhibitor, prevents unfolded protein response during glucose deprivation
- Author(s)
  国政　和宏，冨田　章弘
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25430120
[Presentation] 細胞内ストレス：がん細胞の特徴的代謝とストレス応答
- Author(s)
  冨田章弘
- Organizer
  日本がん分子標的治療学会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-25290061
[Presentation] がん微小環境標的治療法の開発を目指したがん細胞のグルコース飢餓への新たな適応機構の解析
- Author(s)
  冨田章弘
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] Selective cancer cell killing by spautin-1, an autophagy inhibitor, under glucose starvation
- Author(s)
  国政　和宏，冨田　章弘
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25430120
[Presentation] 細胞内ストレス：がん細胞の特徴的代謝とストレス応答
- Author(s)
  冨田章弘
- Organizer
  日本がん分子標的治療学会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-24650626
[Presentation] がん微小環境ストレスに適応したミトコンドリアDNA欠損がん細胞株の樹立とその性状解析
- Author(s)
  冨田章弘
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] がん微小環境標的治療法の開発を目指したがん細胞のグルコース飢餓への新たな適応機構の解析
- Author(s)
  冨田章弘
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24650626
[Presentation] がん微小環境標的治療の分子標的としての新規ストレス応答UPR制御因子TBL2
- Author(s)
  冨田章弘，築茂由則，塚原里美
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24650626
[Presentation] がん微小環境ストレスに適応したミトコンドリアDNA欠損がん細胞株の樹立とその性状解析
- Author(s)
  冨田章弘
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-24650626
[Presentation] 薬剤の制がん作用と関連する遺伝子発現変動データベースの開発
- Author(s)
  冨田章弘
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] がん微小環境ストレスに適応したミトコンドリアDNA欠損がん細胞の樹立とその発現解析
- Author(s)
  冨田章弘
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22300342
[Presentation] がん微小環境ストレスに適応したミトコンドリアDNA欠損がん細胞の樹立とその発現解析
- Author(s)
  冨田章弘
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24650626
[Presentation] がん微小環境標的治療の分子標的としての新規ストレス応答UPR制御因子TBL2
- Author(s)
  冨田章弘，築茂由則，塚原里美
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25290061

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Tomida Akihiro 冨田 章弘

TOMIDA Akihiro 冨田 章弘

冨田 章弘 トミダ アキヒロ

富田 章弘 トミダ アキヒロ

冨田 章宏 トミタ アキヒロ

Research Projects

Research Products

Co-Researchers

合成致死性を司る代謝リプログラミング機構の解明と治療への応用Principal Investigator

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Elucidation of the molecular basis of cancer-specific, metabolic stress response mechanisms and application to drug discoveryPrincipal Investigator

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Molecular basis for synthetic lethality focusing on glucose metabolism and homologous recombination repair in cancer cellsPrincipal Investigator

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Elucidation of molecular basis of diversity in metabolic stress response of cancer cells for drug discoveryPrincipal Investigator

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Elucidation of cooperative mechanisms between energy metabolism and stress response of cancer cells for drug discoveryPrincipal Investigator

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Elucidation of the role of PERK signaling pathway in tumor microenvironment and its application for drug discoveryPrincipal Investigator

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Adaptive mechanisms of cancer cells to unique growth microenvironment and therapeutic targetingPrincipal Investigator

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Molecular therapeutics targeting drug-resistance mechanismsPrincipal Investigator

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プロテアソーム蛋白分解系を標的としたストレス誘導性薬剤耐性の克服Principal Investigator

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低酸素によって誘導されるアポトーシスの制御機構Principal Investigator

Principal Investigator

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Tomida Akihiro 冨田章弘

TOMIDA Akihiro 冨田章弘

冨田章弘トミダアキヒロ

富田章弘トミダアキヒロ

冨田章宏トミタアキヒロ

[Book] 特集・制がん剤の分子標的スクリーニング成績化学療法基盤支援活動報告-制がん候補物質のスクリーニング成績・第15報2013

[Book] 特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告‐制がん候補物質のスクリーニング成績・第15報『癌と化学療法オンライン』2013