KIKUTANI Hitoshi 菊谷仁

… Alternative Names

菊田仁

菊谷仁

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Researcher Number	80161412
Other IDs
Affiliation (based on the past Project Information) *help	1996 – 2012: Research Institute for Microbial Diseases, Osaka University Professor, 微生物病研究所, 教授 2006: Osaka University Research Institute for Microbial Diseases, Professor, 微生物研究所・分子免疫制御分野, 教授 1997: Osaka Univ., Research Institute for microbial Diseases, Prof., 微生物学研究所, 教授 1992 – 1995: Inst. Molec. Cell. Biol., Osaka Univ., Ass. Prof., 細胞生体工学センター, 助教授 1994: 大阪大学, 細胞生体工学センター, 教授 … More 1993: 大阪大学細胞生体工学センター, 助教授 1992: 阪大, 細胞工学セ, 助教授 1989 – 1991: 大阪大学, 細胞工学センター, 助教授 1986 – 1988: 大阪大学, 細胞工学センター, 助手 Less
Review Section/Research Field	Principal Investigator Immunology / Developmental biology / Immunology / Biological Sciences Except Principal Investigator Biological Sciences / Immunology / 内分泌・代謝学 / Virology
Keywords	Principal Investigator CD40 / 自己免疫 / T細胞 / CD72 / CD100 / セマフォリン / B細胞 / CD23 / Sema4A / トランスジェニックマウス … More / ノックアウトマウス / NODマウス / I型糖尿病 / T cell / 樹状細胞 / 副刺激分子 / CD40リガンド / 体液性免疫 / Th1細胞 / 細胞性免疫 / 組織適合性抗原 / 自己抗原 / 遺伝子欠損マウス / SHP1 / LPS / CD40 ligand / クラススイッチ / 体液性免疫反応 / Plexin / プレキシン / 免疫 / シグナル伝達 / EBウイルス / LMP1 / EB-ウイルス / マウス白血病ウイルス / 胚中心形成 / ヘルパーT細胞 / ジーンターゲティング / ストローマ細胞 / 自己免疫疾患 / 抗体産生 / B細胞抗原 / angiogenesis / neural crest cells / cardiac development / Semaphorin / 神経堤細胞 / 神経管 / 破骨細胞 / 細胞遊走 / 心臓 / ガイダンス因子 / 血管新生 / 神経提細胞 / 心臓発生 / B cell / co-stimulatory molecules / 補助刺激分子 / Tim2 / CD100 deficient mouse / semaphorin / CD40 signal / CD100欠損マウス / CD40シグナル / class switch / germinal center / autoimmunity / humoral immune response / 胚中心 / gene-targeted mice / transgenic mice / infection / Th2 T cell / Th1 T cell / cell to cell interaction / 感染免疫 / Th2細胞 / リンパ球相互作用 / Cell-mediated immune response / Infection / Autoimmune / Hemoral immune response / Knock-out mouse / Experimental model mouse / モデル動物 / 感染 / 細胞性免疫反応 / 実験モデルマウス / Type I diabetes / NOD mouse / Autoantigen / MHC class II antigen / Autoimmunity / MHCクラスII分子 / 気道アレルギー / 分子標的 / セマフォリンファミリー / 免疫制御 / リンパ球 / IL-4 / Th2 / Tim-2 / B細胞抗原受容体 / PKN1 / Akt / plexin B2 / Sema4D / アレルギー疾患 / 抗原提示細胞 / 心臓形態形成 / Th1 / plexin / Plexin-A1 / Sema6D / Th2反応 / Th1反応 / CD4t欠損マウス / トランジェニックマウス / 腫瘍免疫 / Bリンパ球 / AIDS / 後天的免疫不全症 / レトロウイルス / Leishmania major / マウス乳腺腫ウィルス / 遺伝子ターゲティング / エレーク / 骨髄 / インタクリン / B細胞初期分化 / T細胞クローン / CD4T細胞 / NOD / 液性免疫 / B細胞腫瘍 / プレB細胞刺激因子 / B細胞造血 / プレB細胞 / クラススイッチング … More Except Principal Investigator CD40 / T細胞 / セマフォリン / サイトカイン / 自己免疫疾患 / B細胞 / インターロイキン6 / 樹状細胞 / CD23 / I型糖尿病 / Foxp3 / 自己免疫病 / Fas / Lyn / Src / SSl-1 / STAT / FasL / 免疫寛容 / TGF-beta / 細胞死 / Biosensor / NMR / 2国間共同研究 / ヒトゲノム / DNA修復 / がん転移 / がん細胞 / シグナル伝達 / がん抑制遺伝子 / がん遺伝子 / signal transduction / autoimmune disease / FcεRII / FcεRIIaとFcεRIIb / 転写因子 / 自己免疫 / CD100 / 免疫病 / 感染症 / Sema4A / 胚中心 / 低親和性IgEレセプター / クラススイッチ / 相同的組換え / ジーンターゲティング / ストロ-マ細胞 / Fcepsilon receptor (FcepsilonRII) / plasmacytoma growth factor / B cell stimulatory factor 2 (BSF2) / Interleukin 6 (IL-6) / Two colour FACS解析 / Bリンパ球増殖因子(BCGF) / 活性化Bリンパ球 / 抗ペプチド抗体Myxoma / 部分アミノ酸配列 / Bリンパ球分因子(BCDF) / Bリンパ球の増殖と分化 / EBV / アトピー / IFNβ2 / 抗体産生 / BSF2 / Fcrレセプター / 抗IL6抗体 / 肝細胞刺激因子 / BiF2 / IL-4 / IL-6レセプターcDNA / IL-6 / Fcεレセプター / IL-6レセプター / ミエローマ増殖因子 / Bリンパ球分化因子 / Immunological self-tolerance / Genetic susceptibilit / Co-stimulatory molecule / Semaphoring / Dendritic cells / Regulatory T cell / Autoimmune disease / CTLA-4 / GITR / 免疫学 / 病理学 / 単クローン抗体 / CD25 / helios / Gpr83 / GITR-L / 移植免疫 / 腫瘍免疫 / 遺伝的疾患感受性 / 教刺激分子 / 免疫自己寛容 / 制御性T細胞 / immune proteasome / NK cell / cytokine receptors / antigen receptors / collaborative research / molecular basis of immune disease / 情報伝達 / B,T細胞分化 / 免疫異常 / 免疫プロテアソーム / NK細胞 / サイトカイン受容体 / 抗原受容体 / 自己抗原病 / 共同研究 / 免疫病の分子基盤 / CD40-CD40L / TCR-peptides / アポトーシス / Smad / TGF-β / TCR / Transcriptional factor / Crystallin gene / Polycomb genes / Transgenics / B cell / Immunological tolerance / T cell / 有機リン系農薬センサー / 水晶体特異的遺伝子発現 / ポリコ-ム遺伝子 / 発生工学 / glucokinase / NOD-mice / activin A / diabetes mellitus / B-cells of pancreatic islets / gene therapy / リンパ球 / 自己抗原 / 遺伝子治療 / 糖尿病 / 膵ラ島B細胞 / tumor suppressor gene / oncogene / human cancer / cancer metastasis / cell-cell interaction / apoptosis / cell differentiation / cell growth / ヒトがん / 細胞間相互作用 / 細胞分化 / 細胞増殖 / Protein interaction / Gene targeting / Higher plants / Morphogenesis / Cre-loxP / Fission yeast / 植物 / 胚形成 / 蛋白高次機能構造 / 遺伝子ターゲティング / RNAプロセシング / バイオモニタリング / DNA再複製 / 細胞周期 / 温度感受性突然変異体 / ATPase / 免疫系 / バイオセンサー / 分子相互作用 / 遺伝子標的 / 高等植物 / 形態形成 / Cre-IoxP / 分裂酵母 / Cancer Metastasis / DNA Repair / Signal Transduction / Tumor Suppressor Genes / Oncogenes / German-Japanese Collaborative Program in Cancer Research / French-Japanese Collaborative Program in Cancer Research / International Exchange Program / がん抑制遣伝子 / がん遣伝子 / nuclear factor / receptor / interleukin 6 / cytokine / acute phase reactions / myeloma / NODマウス / NFーILー6 / ILー6トランスゲニックマウス / シグナルトランスデューサー(gp130) / ILー6レセプター / インターロイキン6(ILー6) / plasmacytoma / ILー6トランスジェニックマウス / 急性期蛋白 / ILー6転写調節因子(NFーILー6) / シグナル伝達分子(gp130) / インタ-ロイキン6レセプタ-(ILー6R) / 自己β細胞特異Tリンパ球 / プラスマサイト-マ / NFーIL6β, / NFーIL6 / ILー6シグナル伝達分子(gp130) / ILー6レセプタ- / インタ-ロイキン6(ILー6) / NF-IL6 / ras / MAPカイネース / タイロシンカイネース / レセプター / 信号伝達 / ミエローマ / 急性期反応 / Estein-Barrウイルス / 細胞形質転換 / モノクローナル抗体 / リンパ腫 / ヘルペスウイルス / 潜伏感染 / Latent membrane protein / Epstein-Barrウイルス / Tim / plexin / 副刺激分子 / 免疫 / ヒトヘルペスウイルス / ヒトヘルペルウイルス6 / 粘膜免疫 / Toll様レセプター / ヒトヘルペスウイルス6 / 自然免疫 / LANA / gH-gL-gO / MyD88非依存症性経路 / TLR / sema6D / PIG-V / GPIアンカー / プロテアソーム / NK1.1 / HLA / MHCの進化 / T細胞分化 / T細胞活性化 / 抗原ペプチド / 抗原提示細胞 / Toll-like receptor / プロテマソーム / HLAゲノム解析 / γδT細胞 / 抗原提示 / T細胞抗原受容体 / MHC / T-B細胞間相互作用 / T-B細胞相互作用 / CD48 / CD34 / 造血幹細胞 / ストローマ細胞 / B細胞初期分化 / SLF / ILー7 / 骨髄 / 胸腺 / モノクロ-ナル抗体 / 細胞接着分子 / トランスジェニックマウス / cーKit / エレ-ヌ Less

Elucidation of the molecular mechanism how EB virus induces the pathogenesis by visualizing viral infection
- Principal Investigator
  
  YASUI Teruhito
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Osaka University
Roles of guidance factors in immune regulationPrincipal Investigator
- Principal Investigator
  
  KIKUTANI Hitoshi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Regulation of tissue morphogenesis by guidance factorsPrincipal Investigator
- Principal Investigator
  
  KIKUTANI Hitoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Developmental biology
- Research Institution
  Osaka University
免疫セマフォリンによる宿主免疫応答の制御
- Principal Investigator
  
  熊ノ郷淳
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
免疫系ホメオスターシスを制御するシグナルの解析Principal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
免疫セマフォリンによる宿主免疫応答の制御
- Principal Investigator
  
  熊ノ郷淳
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Immune tolerance and regulation towards understanding and cure of autoimmune disease
- Principal Investigator
  
  SAKAGUCHI Shimon
- Project Period (FY)
  2001 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Positive and negative regulation of immune resonses through costimulatory interactionsPrincipal Investigator
- Principal Investigator
  
  KIKUTANI Hitoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
免疫識別と応答の多様性の分子機構
- Principal Investigator
  
  西村泰治, SASAZUKI Takehiko
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kumamoto University
  Kyushu University
リンパ球の正常及び異常増殖と副刺激シグナルPrincipal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
Regulation of immune responses and CD40 signalPrincipal Investigator
- Principal Investigator
  
  KIKUTANI Hitoshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Molecular basis for immunological disease
- Principal Investigator
  
  WATANABE Takeshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Immunology
- Research Institution
  KYUSHU UNIVERSITY
感染症と免疫病の分子生物学と医学
- Principal Investigator
  
  山西弘一, KISHIMOTO Tadamitsu
- Project Period (FY)
  1997 – 2003
- Research Category
  
  Grant-in-Aid for COE Research
- Research Institution
  Osaka University
Immune regulation and signal tranduction
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Immunology
- Research Institution
  Juntendo University School of Medicine
Mechanisms of regulation of immune responses by CD40-CD40L interactions.Principal Investigator
- Principal Investigator
  
  KIKUTANI Hitoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
レトロウィルス・宿主免疫系相互作用における副刺激分子Principal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University, School of Medicine
The CD40-CD40 ligand interaction in humoral and cellular immune responses.Principal Investigator
- Principal Investigator
  
  KIKUTANI Hitoshi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
自己免疫性糖尿病における自己抗原の提示及び認識機構に関する研究Principal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
ストローマ細胞由来未熟B細胞刺激因子(PBSF)の作用機構と生理的意義Principal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
CD40及びCD23欠損マウスを用いたB細胞分化・腫瘍化の解析Principal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
液性及び細胞性免疫成立とB細胞costimulatory signalの役割Principal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
自己免疫性糖尿病における自己抗原の提示及び認識機構に関する研究Principal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
CD21、CD23及びCD40欠損マウスを用いたリンパ球間相互作用の解析
- Principal Investigator
  
  吉田進昭
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Research Institute, Osaka Medical Center for Maternal and Child Health
ストローマ細胞由来未熟B細胞刺激因子(PBSF)の作用機構と生理的意義Principal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
CD23及びCD40欠損マウスを用いたB細胞分化-腫瘍化の解析Principal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Cooperation and information exchange with European countries.
- Principal Investigator
  
  KUROKI Toshio
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Showa University
  The University of Tokyo
Molecular Biology of B-Cells of Pancreatic Islets of Langerhans : Basic Study to develop Gene Therapy for Diabetes
- Principal Investigator
  
  ITAKURA Mituo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokushima
Production of Experimntal Model Mice for Studies of lmmunogical Diorders by Gene Targeting.Principal Investigator
- Principal Investigator
  
  KIKUTANI Hitoshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
CD23及びCD40欠損マウスを用いたB細胞分化・腫瘍化の解析Principal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
自己免疫性糖尿病における自己抗原の提示及び認識機構に関する研究Principal Investigator
- Principal Investigator
  
  菊谷仁
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
CD23及びCD40欠損マウスを用いたリンパ球間相互作用の解析
- Principal Investigator
  
  吉田進昭
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Research Institute, Osaka Medical Center for Maternal and Child Health
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University
Studies on the mechanisms of autoimmune diabetes and prevension of the disease in NOD mice.Principal Investigator
- Principal Investigator
  
  KIKUTANI Hitoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
リンパ系幹細胞とストローマ細胞間の相互作用に関する研究
- Principal Investigator
  
  西川伸一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
リンパ系幹細胞とストロ-マ細胞間の相互作用に関する研究
- Principal Investigator
  
  西川伸一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
Cooperation and information exchange with European countries.
- Principal Investigator
  
  KUROKI Toshio
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  University of Tokyo
リンパ系幹細胞とストロ-マ細胞間の相互作用に関する研究
- Principal Investigator
  
  NISHIKAWA Shin-ichi
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
Studies on molecular regulation of the immune system
- Principal Investigator
  
  KISHIMOTO Tadamitsu
- Project Period (FY)
  1989 – 1992
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Osaka University
Bリンパ球増殖・分化機構の解明とその異常制御に関する研究
- Principal Investigator
  
  KISHIMOTO Tadamitsu
- Project Period (FY)
  1985 – 1988
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Institute for Molecular and Cellular Biology, Osaka University

All 2012 2011 2010 2009 2008 2007 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal Y^δ T cell function.2012
- Author(s)
  Witherden DA, Watanabe M, Garijo O, Rieder SE, Sarkisyan G, Cronin SJ, Verdino P, Wilson IA, umanogoh A, Kikutani H, Teyton L, Fischer WH, Havran WL
- Journal Title
  
  Immunity.
  
  Volume: 37(2) Issue: 2 Pages: 314-25
- DOI
  10.1016/j.immuni.2012.05.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation2012
- Author(s)
  Yasui T, Sakakibara-Yada K, Nishimura T, Morita K, Tada S, Mosialos G, Kieff E, Kikutani H
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 109(51) Issue: 51 Pages: 21022-7
- DOI
  10.1073/pnas.1218925110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007, KAKENHI-PROJECT-24590550, KAKENHI-PROJECT-24790883
[Journal Article] Deleterious effects of lymphocytes at the early stage of neurodegeneration in an animal model of amyotrophic lateral sclerosis2011
- Author(s)
  Tada S, Okuno T, Yasui T, NakatsujiY, Sugimoto T, Kikutani H, Sakoda S
- Journal Title
  
  J Neuroinflammation
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590509
[Journal Article] An immunoreceptor adapter protein, DAP12, suppresses adaptive immune responses mediated by B lymphocytes2011
- Author(s)
  Nakano-Yokomizo, T., S. Tahara-Hanaoka, C. Nakahashi-Oda, T. Nabekura, N. K. Tchao, M. Kadosaki, N. Totsuka, N. Kurita, K. Nakamagoe, A. Tamaoka, T. Takai, T. Yasui, H. Kikutani, S. Honda, K. Shibuya, L. L. Lanier, A. Shibuya
- Journal Title
  
  J. Exp. Med.
  
  Volume: 208 Pages: 1661-1671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590509
[Journal Article] Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II2010
- Author(s)
  Takamatsu H, Takegahara N, Nakagawa Y, Tomura M, Taniguchi M, Friedel RH, Rayburn H, Tessier-Lavigne M, Yoshida Y, Okuno T, Mizui M, Kang S, Nojima S, Tsujimura T, Nakatsuji Y, Katayama I, Toyofuku T, Kikutani H, Kumanogoh A
- Journal Title
  
  Nat Immunol.
  
  Volume: 11(7) Issue: 7 Pages: 594-600
- DOI
  10.1038/ni.1885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007, KAKENHI-PROJECT-21590196
[Journal Article] Critical role of IkappaB Kinase alpha in TLR7/ 9-induced type I IFN production by conventional dendritic cells2010
- Author(s)
  Hoshino K, Sasaki I, Sugiyama T, Yano T, Yamazaki C, Yasui T, Kikutani H, Kaisho T
- Journal Title
  
  J. Immunol
  
  Volume: 184 Pages: 3341-3345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590509
[Journal Article] Semaphorins guide cells into the lymphatics by activating myosin II.2010
- Author(s)
  Takamatsu, H., N.Takegahara, Y.Nakagawa, M.Tomura, M.Taniguchi, R.H.Friedel, H.Rayburn, M.Tessier-Lavigne, Y.Yoshida, T.Okuno, M.Mizui, S.Kang, S.Nojima, T.Tsujimura, Y. Nakatsuji, I.Katayama, T.Toyofuku, H.Kikutani, A.Kumanogoh.
- Journal Title
  
  Nat Immunol 11
  
  Pages: 594-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Roles of Sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis.2010
- Author(s)
  Okuno T, Nakatsuji Y, Moriya M, Takamatsu H, Nojima S, Takegahara N, Toyofuku T, Nakagawa Y, Kang S, Friedel RH, Sakoda S, Kikutani H, Kumanogoh A
- Journal Title
  
  J Immunol.
  
  Volume: 184(3) Issue: 3 Pages: 1499-506
- DOI
  10.4049/jimmunol.0903302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Immune semaphorins: novel features of neural guidance molecules.2009
- Author(s)
  Mizui M, Kumanogoh A, Kikutani H.
- Journal Title
  
  J Clin Immunol.
  
  Volume: 29(1) Issue: 1 Pages: 1-11
- DOI
  10.1007/s10875-008-9263-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Enhanced humoral immune responses against T-independent antigens in Fc alpha/ muR-deficient mice2009
- Author(s)
  Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 106 Pages: 11230-11255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590509
[Journal Article] Immune semaphorins : novel features of neural guidance molecules.2009
- Author(s)
  Mizui, M., A.Kuanogoh, H. Kikutani
- Journal Title
  
  J.Clin.Immunol. 29
  
  Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.2008
- Author(s)
  Toyofuku, T.,J.Yoshida, T.Sugimoto, M.Yamamoto, N.Makino, H.Takamatsu, N.Takegahara, F.Suto, M.Hori, H.Fujisawa, A.Kumanogoh, H.Kikutani
- Journal Title
  
  Dev.Biol. 321
  
  Pages: 251-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Bimodal regulation of T cell-mediated immune responses by TIM-4.2008
- Author(s)
  Mizui M, Shikina T, Arase H, Suzuki K, Yasui T, Rennert PD, Kumanogoh A, Kikutani H.
- Journal Title
  
  Int Immunol.
  
  Volume: 20(5) Issue: 5 Pages: 695-708
- DOI
  10.1093/intimm/dxn029
- NAID
  10021241281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Bimodal regulation of T cell-mediated immune responses by TIM-4.2008
- Author(s)
  Mizui, M., T.Shikina, H.Arase, K.Suzuki, T.Yasui, P.D.Rennert, A.Kumanogoh, H.Kikutani
- Journal Title
  
  Int.Immunol. 20
  
  Pages: 695-708
- NAID
  10021241281
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Involvement of Sema4A in the progression of experimental autoimmune myocarditis.2008
- Author(s)
  Makino N, Toyofuku T, Takegahara N, Takamatsu H, Okuno T, Nakagawa Y, Kang S, Nojima S, Hori M, Kikutani H, Kumanogoh A.
- Journal Title
  
  FEBS Lett
  
  Volume: 582(28) Issue: 28 Pages: 3935-40
- DOI
  10.1016/j.febslet.2008.10.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.2008
- Author(s)
  Toyofuku T, Yoshida J, Sugimoto T, Yamamoto M, Makino N, Takamatsu H, Takegahara N, Suto F, Hori M, Fujisawa H, Kumanogoh A, Kikutani H.
- Journal Title
  
  Dev Biol
  
  Volume: 321(1) Issue: 1 Pages: 251-62
- DOI
  10.1016/j.ydbio.2008.06.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Neuropilin-1 : the glue between regulatory T cells and dendritic cells?, 28 : 302-303, 2008.2008
- Author(s)
  Mizui, M., H. Kikutani
- Journal Title
  
  Immunity 28
  
  Pages: 302-303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Immune semaphorins : Increasing members and their diverse roles.2007
- Author(s)
  Kikutani, H., et al.
- Journal Title
  
  Adv. Immunol. 93
  
  Pages: 121-143
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Immune semaphorins : Increasing members and their diverse roles.2007
- Author(s)
  Kikutani, H., et al.
- Journal Title
  
  Adv. Immunol. (in press)
- Data Source
  KAKENHI-PROJECT-18207017
[Journal Article] The FERM domain containing GEF protein FARP2 triggers signals for Sema3A-mediated axonal repulsion.2005
- Author(s)
  Toyofuku, T., Kikutani, H., et al.
- Journal Title
  
  Nature Neurosci 8
  
  Pages: 1712-1719
- Data Source
  KAKENHI-PROJECT-13140204
[Journal Article] Loss of Dopaminerigc Neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD40: Relevance to Parkinson's disease.2005
- Author(s)
  Okuno, T., Kikutani, H., et al.
- Journal Title
  
  J.Neurosci.Res 81
  
  Pages: 874-882
- Data Source
  KAKENHI-PROJECT-13140204
[Journal Article] Semaphorin 4A induces growth cone collapse of hippocampal neurons in a Rho/Rho-kinase-dependent manner.2005
- Author(s)
  Yukawa, K., Kikutani, H., et al.
- Journal Title
  
  Int.J.Mol.Med. 16
  
  Pages: 115-118
- Data Source
  KAKENHI-PROJECT-13140204
[Journal Article] The FERM domain containing GEF protein FARP2 triggers signals for Sema3A-mediated axonal repulsion.2005
- Author(s)
  Toyofuku, T., J.Yoshida, T.Sugimoto, H.Zhang, A.Kumanogoh, M.Hori, H.Kikutani.
- Journal Title
  
  Nature Neurosci. 8
  
  Pages: 1712-1719
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Non-redundant roles of Sema4A in the immune system : Defective T-cell priming and Th1/Th2 regulation in sema4A-deficient mice.2005
- Author(s)
  Kumanogoh, A., H.Kikutani, et al.
- Journal Title
  
  Immunity 22
  
  Pages: 1-12
- Data Source
  KAKENHI-PROJECT-13140204
[Journal Article] Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment.2005
- Author(s)
  Kumanogoh, A., Kikutani, H., et al.
- Journal Title
  
  Int.Immunol. 17
  
  Pages: 1277-1282
- NAID
  10016810755
- Data Source
  KAKENHI-PROJECT-13140204
[Journal Article] Semaphoris: a new class of immunoregulatory molecules.2005
- Author(s)
  Takegahara, N., Kumanogoh, A., Kikutani, H.
- Journal Title
  
  Philos.Trans.R.Soc.Lond B.Biol.Sci 360
  
  Pages: 1673-168
- Data Source
  KAKENHI-PROJECT-13140204
[Journal Article] Biological functions and signaling of a transmembrane semaphorine, CD 100/Sema4A.2004
- Author(s)
  Kumanogoh, A., H.Kikutani.
- Journal Title
  
  Cell Mol.Life Sci. 61
  
  Pages: 292-300
- Data Source
  KAKENHI-PROJECT-13140204
[Journal Article] Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-Al, with off-track and vascular endothelial growth factor receptor type 2.2004
- Author(s)
  T Toyofuku, T., A.Kumanogoh, H.Kikutani, et al.
- Journal Title
  
  Genes & Dev. 18
  
  Pages: 435-447
- Data Source
  KAKENHI-PROJECT-13140204
[Journal Article] Guidance of myocardial patterning in cardiac development by Sema6D reverse signaling.2004
- Author(s)
  T Toyofuku, T., A.Kumanogoh, H.Kikutani, et al.
- Journal Title
  
  Nature Cell Biol. 6
  
  Pages: 1204-1211
- Data Source
  KAKENHI-PROJECT-13140204
[Journal Article] Semaphorins in interactions between T cells and antige-presenting cells.2003
- Author(s)
  Kikutani H, et al.
- Journal Title
  
  Nat Rev Immunol. 3
  
  Pages: 159-67
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Semaphorins in interactions between T cells and antigen-presenting cells.2003
- Author(s)
  Kikutani H, et al.
- Journal Title
  
  Nat Rev Immunol. 3
  
  Pages: 159-67
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Immune semaphorins : Increasing members and their diverse roles. 2007
- Author(s)
  Kikutani, H., et al.
- Journal Title
  
  Adv. Immunol. 93
  
  Pages: 121-143
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Presentation] Expression of EB virus LMP2a modifies the selection of B cells in germinal center.2012
- Author(s)
  Minamitani, T., T. Yasui, and H. Kikutani.
- Organizer
  International Congress on Oncogenic Herpesviruses and Associated Diseases
- Place of Presentation
  Philadelphia, Pennsylvania, USA.
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] Novel endogenous regulator of Th2 inflammation: Semaphorins2012
- Author(s)
  Kikutani, H.
- Organizer
  2012 Annual Meeting of American Academy of Allergy Asthma & Immunology
- Place of Presentation
  Orlando, Florida, USA.
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] Novel endogenous regulator of Th2 inflammation : Semaphorins2012
- Author(s)
  菊谷仁
- Organizer
  2012 Annual Meeting of American Academy of Allergy Asthma & Immunology
- Place of Presentation
  Orlando, Florida, USA(招待講演)
- Year and Date
  2012-03-02
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] Semaphorins in immune cell communication.2010
- Author(s)
  Kikutani, H.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan.
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] Semaphorins in immune cell communication.2010
- Author(s)
  菊谷仁
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  兵庫県・神戸国際展示場(招待講演)
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] Comprehensive detection assay of physiological interaction partners for the Epstein-Barr virus latent membrane protein 1 by bimolecular fluorescence complementation system coupled with enhanced retrovirus mutagenesis.2010
- Author(s)
  Mizui, M., T.Yasui, K.Morita, T.Morimoto, S.Tada, H.Kikutani
- Organizer
  The 14^<th> Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases.
- Place of Presentation
  Birmingham, UK.
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] A role of protein kinase N1 in quality control of germinal center B cells.2010
- Author(s)
  Kikutani, H.
- Organizer
  9th International Conference on Human Leukocyte Differentiation Antigen
- Place of Presentation
  Barcelona, Spain.
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] Semaphorins in immune cell communication.2010
- Author(s)
  Kikutani, H
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] A role of protein kinase N1 in qualilty control of germinal center Bcells.2010
- Author(s)
  菊谷仁
- Organizer
  9^<th> International Conference on Human Lyukocyte Differentiation Antigen.
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2010-03-12
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] A role of protein kinase N1 in quality control of germinal center B cells.2010
- Author(s)
  Kikutani, H.
- Organizer
  9^<th> International Conference on Human Leukocyte Differentiation Antigen.
- Place of Presentation
  Barcelona, Spain.
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] Semaphorins and inflammatory resonses.2009
- Author(s)
  Kikutani, H.
- Organizer
  EMBO Workshop "Semaphorin Function & Mechanisms of Actioni"
- Place of Presentation
  Cernay, France
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] Semaphorins and inflammatory resonses.2008
- Author(s)
  Kikutani, H.
- Organizer
  EMBO Workshop "Semaphorin Function & Mechanisms of Action"
- Place of Presentation
  Cernay, France
- Data Source
  KAKENHI-PROJECT-20229007

1. YASUI Teruhito (60283074)

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# of Collaborated Projects: 6 results

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KIKUTANI Hitoshi 菊谷 仁

菊田 仁

菊谷 仁

Research Projects

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Roles of guidance factors in immune regulationPrincipal Investigator

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Regulation of tissue morphogenesis by guidance factorsPrincipal Investigator

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免疫系ホメオスターシスを制御するシグナルの解析Principal Investigator

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Positive and negative regulation of immune resonses through costimulatory interactionsPrincipal Investigator

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リンパ球の正常及び異常増殖と副刺激シグナルPrincipal Investigator

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Regulation of immune responses and CD40 signalPrincipal Investigator

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Mechanisms of regulation of immune responses by CD40-CD40L interactions.Principal Investigator

KIKUTANI Hitoshi 菊谷仁

菊田仁

菊谷仁