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Akiyama Tetsu  秋山 徹

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AKIYAMA Tetsu  秋山 徹

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Researcher Number 70150745
Other IDs
Affiliation (Current) 2025: 東京大学, 定量生命科学研究所, 特任教授
Affiliation (based on the past Project Information) *help 2017 – 2023: 東京大学, 定量生命科学研究所, 特任教授
2017: 東京大学, 分子細胞生物学研究所, 教授
1998 – 2014: Institute of Molecular and Cellular Biosciences, The University of Tokyo, 分子細胞生物学研究所, 教授
1999: 東京大学, 分子細胞学研究所, 教授
1997: 大阪大学, 微生物学研究所, 教授 … More
1994 – 1997: RESEARCH INSTITUTE FOR MICROBIAL DISEASES OSAKA UNIVERSITY DEPARTMENT OF ONCOGENE RESEARCH PROFESSOR, 微生物病研究所, 教授
1994: 大阪大, 微研, 教授
1994: Institute of Virus Research, University of Osaka, Professor, 微生物研究所, 教授
1994: 大阪大学微生物病研究所, 教授
1993: 大阪大学, 微研, 助教授
1990 – 1993: Associate Prof., Research Institute of Microbial Diseases, Osaka University, 微生物病研究所, 助教授
1992: 大阪大学, 微生物病研究所・発癌遺伝子部門, 助教授
1992: 大阪大学, 微生物研究所, 助教授
1992: 阪大, 微生物学研究所, 助教授
1991: 微生物病研究所, 発癌遺伝子部門, 助教授
1990: 大阪大学, 細胞工学センター, 助教授
1990: 大阪大学微生物病研究所, 発癌遺伝子部門, 助教授
1989: 東京大学, 医科学研究所・制癌研究部, 助手
1987 – 1988: 京都大学, ウイルス研究所, 助手
1986: 明治薬大, 薬学部, 助手
1986: 明治薬科大学, 助手
1986: 東京大学, 医科学研究所, 非常勤講師 Less
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / Pathological medical chemistry / General medical chemistry / Biological Sciences / Basic Section 49010:Pathological biochemistry-related / Complex systems / Biological Sciences
Except Principal Investigator
Biological Sciences / Complex systems / Basic Section 56020:Orthopedics-related / Human pathology / Biological Sciences / Experimental pathology
Keywords
Principal Investigator
癌抑制遺伝子 / シグナル伝達 / p53 / 細胞周期 / WT1 / APC / アポトーシス / CDK / β-catenin / がん抑制遺伝子 … More / チロシンキナーゼ / 癌遺伝子 / 癌 / TPA / Bim / Tumor suppressor / TGF-β / apoptosis / splicing / 老化 / 寿命 / がん / がん幹細胞 / TGF-b / Asef / cyclin / Wilms腫瘍 / SPAL / Wntシグナル / 代謝 / TGF-beta / RNA-binding protein / ノックアウトマウス / KHドメイン / RNA結合蛋白質 / STK11 / LKB1 / PSD-95 / 標的遺伝子 / DPC4 / 転写制御 / leukemia / cell cycle / Wilms tumor / 白血病 / 転写因子 / チロシンリン酸化 / 分化 / non-coding RNA / NMDA受容体 / Dlg / RICS / beta-catenin / 増殖 / 細胞膜裏打ち蛋白質 / 細胞運動 / Wnt / DLG / 大腸がん / ICAT / G蛋白質 / がん遺伝子 / キナーゼカスケード / スレオニンキナーゼ / セリン / 蛋白質リン酸化 / リン酸化 / がん化 / インスリン抵抗性 / 中和抗体 / モノクローナル抗体 / 膜タンパク質 / 分泌タンパク質 / 細胞老化 / 遺伝子発現 / インスリン感受性 / 転写後調節 / RNA結合タンパク質 / SASP / 癌幹細胞 / scRNA-seq / 細胞・組織 / 線維芽細胞 / 免疫細胞 / 細胞間相互作用 / 1細胞解析 / 造腫瘍能 / 腫瘍内不均一性 / がん微小環境 / 1細胞RNA-seq / estrogen / KH domain / PNA / 3'-UTR / D8 / エストロジェン / 発現誘導 / Serine-threonine kinase / Hamartomatous polyps / Peutz-Jeghers syndrome / 好発癌性疾患 / LKB1AP / Peutz-Jeghers症候群 / セリン・スレオニンキナーゼ / 過誤腫性ポリポーシス / Peutz-Jehers症候群 / learning / post synaptic density / synapse / NMDA receptor / NMAD受容体 / 海馬 / 神経 / シナプス可塑性 / 長期増強 / 記憶 / Cell Cycle / Subtraction / One-hybrid / Target gene / シグナル伝達、 / 細胞周期、 / 増殖制御、 / TAB-1, / TAK1, / TGF-b, / DPC-4, / サブトラクション / one-hybrid / M1 / Glarrest / tumor suppressor gene / サイクリン / M1細胞 / G1 arrest / differentiation / Tumor suppressor gene / Transcription factor / WT蛋白質 / WT遺伝子 / zinc finger / Zinc finger / トランスフォメーション / C-erbB-2 / 増殖因子受客体 / トランスフォーメーション / CーerbBー2 / 増殖因子受容体 / 脂肪組織 / RNAiライブラリー / ncRNA / 低酸素 / 分子標的 / 神経膠芽腫 / GATA6 / Lgr5 / hydroxymethyl化 / 造腫瘍性 / 微小環境 / N-cadherin / PX-RIGS / 樹状突起 / ニューロン / 14-3-3ζ/θ / シナグル伝達 / GABARAP / 14-3-3 / CaMKII / RICS/PX-RICS / スパイン / 脳・神経 / 神経可塑性 / 分子神経生物学 / 細胞内情報伝達 / sFRP / sFRP2 / Wnt シグナル / Runx / B9L / Sam68 / GEF / 血管新生 / 神経突起伸長 / カドヘリン / 細胞運動・浸潤 / 細胞がん化 / 細胞接着 / PAPIN / MAG1 / BAOP1 / KAP3 / がん細胞 / 接着 / 裏打ち蛋白 / 細胞同期 / Cyclin-CDR / G1-S移行 / armadillo / SH3ドメイン / ドメイン / guanylate kinase / D2 / b-catenin / hDLG / APCL / βTrCP / Slimb / D-Axin / Axin / TCF / 大腸癌 / SH2 / 受容体 / プロテインキナーゼ / チロシンキナ-ゼ / 細胞増殖 / 蛋白質リン酸化酵素 … More
Except Principal Investigator
がん抑制遺伝子 / がん遺伝子 / シグナル伝達 / DNA修復 / 遺伝子 / 癌 / 転移 / 細胞増殖 / 細胞周期 / 細胞死 / がん細胞 / アデノウイルス / p53 / RB / RBタンパク / 再生医療 / 臨床 / 細胞・組織 / signal transduction / oncogene / RIA / ELISA / 癌遺伝子 / チロシンキナーゼ / 浸潤 / 細胞接着 / 細胞外マトリックス / 浸潤・転移 / 分化 / 増殖因子 / がん / 2国間共同研究 / ヒトゲノム / がん転移 / パピロ-マウイルス / トランスフォ-メ-ション / トランスフォ-ム遺伝子 / HBVXタンパク / 試験管内DNA複製系 / 染色体欠失 / 肺転移 / オルガノイド / 肉腫幹細胞 / オルガノイドモデル / 幹細胞 / 肉腫 / 病理学 / 分子標的治療 / 数理科学 / German-Japanese collaborative program in cancer research / French-Japanese collaborative programe in cancer research / Growth Factors / Cytokines / Tumor Suppressor Genes / Oncogenes / Human Gene Mapping / International Exchange Program / サイトカイン / 発がん / ヒトがん遺伝子 / ヒトレトロウイルス / stress / intracellular signal transduction / enzyme / environment / gene / 細胞生物学 / 分子生物学 / MAPキナーゼ / ストレス応答 / 細胞内シグナル伝達 / ストレス / 酵素 / 環境 / Gene Therapy / Drug Design / Cell Adhesion / Cell Cycle / Signal Transduction / Information Exchange / Cancer / International Scientific Research / 癌化学療法 / 癌遺伝子治療 / ドラッグデザイン / 情報交換 / 化学発癌 / 癌治療 / ウイルス発癌 / 遺伝子治療 / 薬品設計 / 細胞社会学 / 海外派遣 / 国際学術 / tumor suppressor gene / human cancer / cancer metastasis / cell-cell interaction / apoptosis / cell differentiation / cell growth / ヒトがん / 細胞間相互作用 / 細胞分化 / check point / small G protein / Trichustatin / end of mitosis / cell cycle / 線維芽細胞 / IL-2 / 低分子量G蛋白質 / DNA複製 / 出芽酵母 / チェックポイント / 低分子量Gタンパク質 / トリコスタチン / 信号伝達 / M期終了 / c-erbB-2 / steroid hormone / serodiagnosis / breast cancer / 癌胎児性蛋白 / 膀胱癌 / 受容体 / erbB-2 / ステロイドホルモン / 血清診断 / 乳癌 / Transcriptional regulation / Growth control / Cancer cells / Tumor suppressor gene / Tumor promoter / Tumor virus / Oncogene / Information exchange / 研究集会 / 研究室訪問 / 北米 / 研究交流 / がん研究 / 転写調節 / 増殖制御 / 発がんプロモーター / ウイルス発がん / 研究情報交換 / 酵素阻害剤 / 免疫応答 / トランスジェニック動物 / 発癌遺伝子 / ホスホチロシン抗体 / ゲノム医学 / リンパ管新生 / 血管新生 / がん浸潤 / がん微小環境 / ゲノム科学 / 生体イメージング / 生体材料 / 微小環境 / 接着 / 細胞極性 / 増殖 / 組織 / 細胞運動 / 2国間協同研究 / パピローマウイルス / トランスフォーメション / トランスフォーム遺伝子 / 色素性乾皮症 / T抗原 / DNAヘリカーゼ / DNAポリメラーゼα / SV40DNA / トポイソメラ-ゼ / DNAヘリカ-ゼ / プライマ-ゼ / DNAポリメラ-ゼ / SV40ミニクロモソ-ム / 第3染色体 / RB遺伝子 / 肺がん / 乳がん / ウイルムス腫瘍 / 多内分泌腺腫瘍症 / 神経芽細胞腫 / 網膜芽細胞腫 / DNAアフィニティカラム / ヌクレオソ-ム / 2 / CDC28 / 自律増殖配列 / cーmycタンパク Less
  • Research Projects

    (48 results)
  • Research Products

    (171 results)
  • Co-Researchers

    (199 People)
  •  Integrated analysis and regulation of cellular diversity

    • Principal Investigator
      藤田 直也
    • Project Period (FY)
      2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Functional analysis of novel senescence-inducing factors secreted by senescent cells.Principal Investigator

    • Principal Investigator
      AKIYAMA Tetsu
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      The University of Tokyo
  •  Elucidation of mechanisms of sarcoma progression and metastasis using human sarcoma stem cells and organoid models

    • Principal Investigator
      Matsumine Akihiko
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      University of Fukui
  •  Integrated analysis and regulation of cellular diversity

    • Principal Investigator
      FUJITA Naoya
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Single-cell analysis of tumor heterogeneity arising from the evolution of cancer stem cellsPrincipal Investigator

    • Principal Investigator
      Akiyama Tetsu
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      The University of Tokyo
  •  Elucidation of the molecular mechanisms of aging using mice with extended longevityPrincipal Investigator

    • Principal Investigator
      Akiyama Tetsu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokyo
  •  The analysis for molecular mechanism of lifespan regulation by RNA binding proteinPrincipal Investigator

    • Principal Investigator
      AKIYAMA Tetsu
    • Project Period (FY)
      2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokyo
  •  Integrative Research on Cancer Microenvironment Network

    • Principal Investigator
      MIYAZONO Kohei
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Analysis of the interaction between cancer stem cells and their microenvironment.Principal Investigator

    • Principal Investigator
      AIYAMA Tetsu
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Activity-dependent regulation of spine morphology by RICS/PX-RICSPrincipal Investigator

    • Principal Investigator
      AKIYAMA Tetsu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokyo
  •  The Dlg signal transduction pathwayPrincipal Investigator

    • Principal Investigator
      AKIYAMA Tetsu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokyo
  •  Molecular mechanism of tumor cell growthPrincipal Investigator

    • Principal Investigator
      AKIYAMA Tetsu
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Molecular mechanism of apotosis induced by a novel RNA-binding protein D8Principal Investigator

    • Principal Investigator
      AKIYAMA Tetsu
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokyo
  •  Disorganization of cell and tissue systems in cancer

    • Principal Investigator
      TAKAI Yoshimi
    • Project Period (FY)
      2004 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kobe University
      Osaka University
  •  Molecular mechainism of apotosis induced by a novel RNA binding protein D8Principal Investigator

    • Principal Investigator
      AKIYAMA Tetsu
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokyo
  •  Regulatory Mechanism of Stress-Responsive Signal Transduction Pathway

    • Principal Investigator
      SAITO Haruo
    • Project Period (FY)
      2002 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Studies on the function of LKB I /STK II, a Ser/Thr kinase mutated in Peutz-Jeghers syndromePrincipal Investigator

    • Principal Investigator
      AKIYAMA Testu
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokyo
  •  細胞周期の制御異常Principal Investigator

    • Principal Investigator
      秋山 徹
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  ヨーロッパなどががん研究先進国との研究交流

    • Principal Investigator
      KUROKI Toshio
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Showa University
  •  がんの生物学的特性に関する研究の総括

    • Principal Investigator
      TAKAI Yoshimi
    • Project Period (FY)
      1999 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Functional Analysis of the NMDA-recepter-APC-DLG-Complex.Principal Investigator

    • Principal Investigator
      AKIYAMA Testu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokyo
  •  TGF-β-DPC-4 mediated cell cycle regulationPrincipal Investigator

    • Principal Investigator
      AKIYAMA Tetsu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokyo
      Osaka University
  •  Wilms tumor suppressor gene WT1 blocks cell cycle progressionPrincipal Investigator

    • Principal Investigator
      AKIYAMA Tetsu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  癌抑制遺伝子の作用機構Principal Investigator

    • Principal Investigator
      秋山 徹
    • Project Period (FY)
      1994 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
      Osaka University
  •  Cooperation and information exchange with European countries.

    • Principal Investigator
      KUROKI Toshio
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Showa University
      The University of Tokyo
  •  Information Exchange on Cancer Research with North American

    • Principal Investigator
      YAMAMOTO Tadashi
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      The University of Tokyo
  •  Molecular mechanisms of G1/s transition

    • Principal Investigator
      TUH-E Akio
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  DNA複製反応の促進及び抑制のメカニズムと癌化

    • Principal Investigator
      吉田 松年
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  がん遺伝子とがん抑制遺伝子の相互作用による発がんの分子機構

    • Principal Investigator
      藤永 慧
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  Characterization of the Wilms tumor gene product WT1Principal Investigator

    • Principal Investigator
      AKIYAMA Tetsu
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  Use of receptor-type oncogene c-ergB-2 for the diagnosis and treatment of human cancers

    • Principal Investigator
      MORI Shigeo
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      The University of Tokyo
  •  DNA複製反応の促進及び抑制のメカニズムと癌化

    • Principal Investigator
      吉田 松年
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  細胞癌化における蛋白質リン酸化Principal Investigator

    • Principal Investigator
      秋山 徹
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  がん遺転子とがん抑制遺伝子の相互作用による発がんの分子機構

    • Principal Investigator
      藤永 けい
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  細胞癌における蛋白質リン酸化Principal Investigator

    • Principal Investigator
      秋山 徹
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  細胞がん化における蛋白質リン酸化Principal Investigator

    • Principal Investigator
      秋山 徹
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  Information Exchange on Cancer Research with North American Countries.

    • Principal Investigator
      YAMAGUCHI Nobuo
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Institute of Medical Science, University of Tokyo
  •  DNA複製反応の促進及び抑制のメカニズムと癌化

    • Principal Investigator
      吉田 松年
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  がん抑制に関与する遺伝子群の研究

    • Principal Investigator
      佐々木 正夫
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University
  •  がん遺伝子とがん抑制遺伝子の相互作用による発がんの分子機構

    • Principal Investigator
      藤永 〓
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  非遺伝性腫瘍における染色体欠失及びがん抑制遺伝子異常に関する研究

    • Principal Investigator
      横田 淳
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  非遺伝性腫瘍における染色体欠失及びがん抑制遺伝子異常に関する研究

    • Principal Investigator
      YOKOTA Jun
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  受容体型癌遺伝子の機能と細胞増殖の脱制御Principal Investigator

    • Principal Investigator
      秋山 徹
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University
  •  Cooperation and Information Exchange with European Countries

    • Principal Investigator
      KUROKI Toshio
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Institute of Medical Science, University of Tokyo
  •  受容体型癌遺伝子の機能と細胞増殖の脱制御Principal Investigator

    • Principal Investigator
      秋山 徹
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University
  •  細胞増殖・癌化機構におけるチロシン燐酸化標的蛋白質の同定とその生理的役割

    • Principal Investigator
      春日 雅人
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  発癌遺伝子を導入されたトランスジエニック動物での遺伝子産物の発現とその免疫応答

    • Principal Investigator
      森 庸厚
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  発癌遺伝子産物の機能阻害を指標とした制癌剤の開発

    • Principal Investigator
      小河原 宏
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Meiji Pharmaceutical University

All 2022 2021 2020 2019 2018 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation Book Patent Other

  • [Book] がん微小環境に1細胞レベルで挑む2021

    • Author(s)
      林 寛敦, 秋山 徹 (分担執筆、藤田 直也/編
    • Total Pages
      220
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-21H02693
  • [Book] がん微小環境に1細胞レベルで挑む2021

    • Author(s)
      林 寛敦, 秋山 徹 (分担執筆、藤田 直也/編)
    • Total Pages
      220
    • Publisher
      羊土社
    • ISBN
      9784758103961
    • Data Source
      KAKENHI-PLANNED-17H06325
  • [Book] シングルセルゲノミクス「11. シングルセル遺伝子発現解析からみえてきた腫瘍内不均一性」2019

    • Author(s)
      林 寛敦、秋山 徹
    • Total Pages
      219
    • Publisher
      羊土社
    • ISBN
      9784758103831
    • Data Source
      KAKENHI-PLANNED-17H06325
  • [Book] 細胞・培地活用ハンドブック2007

    • Author(s)
      秋山徹, 河府和義
    • Total Pages
      397
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Book] 阻害剤活用ハンドブック2006

    • Author(s)
      秋山徹, 河府和義
    • Total Pages
      468
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Book] がん細胞の生物学2006

    • Author(s)
      高井義美, 秋山徹
    • Total Pages
      179
    • Publisher
      東京大学出版会
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] Altered cervicovaginal microbiota in premenopausal ovarian cancer patients2022

    • Author(s)
      Morikawa Asuka、Kawabata Ayako、Shirahige Katsuhiko、Akiyama Tetsu、Okamoto Aikou、Sutani Takashi
    • Journal Title

      Gene

      Volume: 811 Pages: 146083-146083

    • DOI

      10.1016/j.gene.2021.146083

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-21H02693, KAKENHI-PROJECT-21K15560
  • [Journal Article] Hypoxia-inducible factor 1α induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL92022

    • Author(s)
      Orikasa Shion、Kawashima Nobuyuki、Tazawa Kento、Hashimoto Kentaro、Sunada-Nara Keisuke、Noda Sonoko、Fujii Mayuko、Akiyama Tetsu、Okiji Takashi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 682-682

    • DOI

      10.1038/s41598-021-04453-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-21H02693, KAKENHI-PROJECT-21K09870, KAKENHI-PROJECT-21K16989
  • [Journal Article] The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR‐Cas9 screen2022

    • Author(s)
      Cona Brandon、Hayashi Tomoatsu、Yamada Ai、Shimizu Naomi、Yokota Naoko、Nakato Ryuichiro、Shirahige Katsuhiko、Akiyama Tetsu
    • Journal Title

      FEBS Open Bio

      Volume: 12 Issue: 3 Pages: 582-593

    • DOI

      10.1002/2211-5463.13358

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06325, KAKENHI-PLANNED-17H06331, KAKENHI-PROJECT-21H02693
  • [Journal Article] The phosphate exporter XPR1/SLC53A1 is required for the tumorigenicity of epithelial ovarian cancer2022

    • Author(s)
      Akasu‐Nagayoshi Yoko、Hayashi Tomoatsu、Kawabata Ayako、Shimizu Naomi、Yamada Ai、Yokota Naoko、Nakato Ryuichiro、Shirahige Katsuhiko、Okamoto Aikou、Akiyama Tetsu
    • Journal Title

      Cancer Science

      Volume: - Issue: 6 Pages: 2034-2043

    • DOI

      10.1111/cas.15358

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-21H02693, KAKENHI-PROJECT-21K07146
  • [Journal Article] SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling2022

    • Author(s)
      Matsuura K., Kobayashi S., Konno K., Yamasaki M., Horiuchi T., Senda T., Hayashi T., Satoh K., Arima-Yoshida F., Iwasaki K., Negishi L., Yasui-Shimizu N., Kohu K., Kawahara S., Kirino Y., Nakamura T., Watanabe M., Yamamoto T., Manabe T. and Akiyama T.
    • Journal Title

      The Journal of Neuroscience

      Volume: 42 Issue: 12 Pages: 2448-2473

    • DOI

      10.1523/jneurosci.0569-21.2022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06901, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-19H03321, KAKENHI-PROJECT-21H02693, KAKENHI-PROJECT-20H03410
  • [Journal Article] CRISPR/Cas9 Screening for Identification of Genes Required for the Growth of Ovarian Clear Cell Carcinoma Cells2022

    • Author(s)
      Kawabata Ayako、Hayashi Tomoatsu、Akasu-Nagayoshi Yoko、Yamada Ai、Shimizu Naomi、Yokota Naoko、Nakato Ryuichiro、Shirahige Katsuhiko、Okamoto Aikou、Akiyama Tetsu
    • Journal Title

      Current Issues in Molecular Biology

      Volume: 44 Issue: 4 Pages: 1587-1596

    • DOI

      10.3390/cimb44040108

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-21H02693, KAKENHI-PROJECT-21K07146
  • [Journal Article] Codependency and mutual exclusivity for gene community detection from sparse single-cell transcriptome data2021

    • Author(s)
      Nakajima N, Hayashi T, Fujiki K, Shirahige K, Akiyama T, Akutsu T, Nakato R.
    • Journal Title

      Nucleic Acids Res

      Volume: 49 Issue: 18 Pages: e104-e104

    • DOI

      10.1093/nar/gkab601

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21384, KAKENHI-PLANNED-17H06325, KAKENHI-PLANNED-17H06331, KAKENHI-PLANNED-20H05940, KAKENHI-PROJECT-21H02693
  • [Journal Article] Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells2020

    • Author(s)
      Shibata Norihito、Ohoka Nobumichi、Tsuji Genichiro、Demizu Yosuke、Miyawaza Keiji、Ui-Tei Kumiko、Akiyama Tetsu、Naito Mikihiko
    • Journal Title

      Oncogene

      Volume: - Issue: 19 Pages: 3867-3878

    • DOI

      10.1038/s41388-020-1253-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502, KAKENHI-ORGANIZER-18H05497
  • [Journal Article] UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells2019

    • Author(s)
      Taniue Kenzui、Hayashi Tomoatsu、Kamoshida Yuki、Kurimoto Akiko、Takeda Yasuko、Negishi Lumi、Iwasaki Kei、Kawamura Yoshifumi、Goshima Naoki、Akiyama Tetsu
    • Journal Title

      Oncogene

      Volume: 39 Issue: 5 Pages: 1018-1030

    • DOI

      10.1038/s41388-019-1032-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K15804, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-ORGANIZER-17H06324
  • [Journal Article] The RNA-binding protein Mex-3B plays critical roles in the development of steroid-resistant neutrophilic airway inflammation2019

    • Author(s)
      Yamazumi Yusuke、Sasaki Oh、Suyama-Fuchino Saki、Kohu Kazuyoshi、Kamoshida Yuki、Harada Hiroaki、Fujio Keishi、Oda Takeaki、Akiyama Tetsu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 519 Issue: 2 Pages: 220-226

    • DOI

      10.1016/j.bbrc.2019.08.158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K15804, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537
  • [Journal Article] The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis2019

    • Author(s)
      Kawasaki Y、Miyamoto M、Oda T、Matsumura K、Negishi L、Nakato R、Suda S、Yokota N、Shirahige K、Akiyama T.
    • Journal Title

      EMBO reports

      Volume: 20 Issue: 8

    • DOI

      10.15252/embr.201847052

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-17H06324, KAKENHI-PLANNED-17H06325, KAKENHI-PLANNED-17H06331, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-20K20379, KAKENHI-PROJECT-16H04692
  • [Journal Article] Sp5 negatively regulates the proliferation of HCT116 cells by upregulating the transcription of p272018

    • Author(s)
      Miyamoto M, Hayashi T, Kawasaki Y, Akiyama T.
    • Journal Title

      Oncol Lett.

      Volume: 15 Pages: 4005-4009

    • DOI

      10.3892/ol.2018.7793

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19584, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-16H04692
  • [Journal Article] The autism-related protein PX-RICS mediates GABAergic synaptic plasticity in hippocampal neurons and emotional learning in mice.2018

    • Author(s)
      Nakamura T, Sakaue F, Nasu-Nishimura Y, Takeda Y, Matsuura K, Akiyama T
    • Journal Title

      EBioMedicine

      Volume: 34 Pages: 189-200

    • DOI

      10.1016/j.ebiom.2018.07.011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07104, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537
  • [Journal Article] PIK3CA and KRAS mutations in cell free circulating DNA are useful markers for monitoring ovarian clear cell carcinoma.2018

    • Author(s)
      Morikawa A., Hayashi T., Shimizu N., Kobayashi M., Taniue K., Takahashi A., Tachibana K., Saito M., Kawabata A., Iida Y., Ueda K., Saito M., Yanaihara N., Tanabe H., Yamada K., Takano H., Nureki O., Okamoto A. and Akiyama T.
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 20 Pages: 15266-15274

    • DOI

      10.18632/oncotarget.24555

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-15K08299, KAKENHI-PROJECT-17H01537
  • [Journal Article] Mex-3B induces apoptosis by inhibiting miR-92a access to the Bim-3′UTR2018

    • Author(s)
      Oda Takeaki、Yamazumi Yusuke、Hiroko Takatoshi、Kamiya Atsushi、Kiriya Saori、Suyama Saki、Shiozaki-Sato Yumi、Akiyama Tetsu
    • Journal Title

      Oncogene

      Volume: 37 Issue: 38 Pages: 5233-5247

    • DOI

      10.1038/s41388-018-0336-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537
  • [Journal Article] Somatic copy number alterations have prognostic impact in patients with ovarian clear cell carcinoma2018

    • Author(s)
      Morikawa Asuka、Hayashi Tomoatsu、Kobayashi Mana、Kato Yuki、Shirahige Katsuhiko、Itoh Takehiko、Urashima Mitsuyoshi、Okamoto Aikou、Akiyama Tetsu
    • Journal Title

      Oncology Reports

      Volume: 40 Pages: 309-318

    • DOI

      10.3892/or.2018.6419

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537
  • [Journal Article] Somatic copy number alterations have prognostic impact in patients with ovarian clear cell carcinoma.2018

    • Author(s)
      Morikawa A., Hayashi T., Kobayashi M., Kato Y., Shirahige K., Itoh T., Urashima M., Okamoto A., Akiyama T.
    • Journal Title

      Oncology Reports

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-17H06325
  • [Journal Article] Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction.2015

    • Author(s)
      Meng F, Meliton A, Moldobaeva N, Mutlu G, Kawasaki Y, Akiyama T, Birukova AA.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 308 Issue: 5 Pages: 452-463

    • DOI

      10.1152/ajplung.00170.2014

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25290043
  • [Journal Article] SOX9-mediated upregulation of LGR5 is important for glioblastoma tumorigenicity.2015

    • Author(s)
      Hiraoka K, Hayashi T, Kaneko R, Nasu-Nishimura Y, Koyama-Nasu R, Kawasaki Y, Akiyama T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 460 Issue: 2 Pages: 4097-4109

    • DOI

      10.1016/j.bbrc.2015.03.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-24501313, KAKENHI-PROJECT-25290043
  • [Journal Article] Thr160 of Axin1 is critical for the formation and function of the β-catenin destruction complex.2015

    • Author(s)
      Koyama-Nasu R, Hayashi T, Nasu-Nishimura Y, Akiyama T, Yamanaka R
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 459 Issue: 3 Pages: 411-415

    • DOI

      10.1016/j.bbrc.2015.02.118

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-24501313, KAKENHI-PROJECT-24390347, KAKENHI-PROJECT-26670646
  • [Journal Article] Susceptibility to proteases of anti-Tn-antigen MLS128 binding glycoproteins expressed in human colon cancer cells2015

    • Author(s)
      Oura, F., Yajima, Y., Nakata, M., Taniue, K., Akiyama, T., Nakada, H., Yamamoto, K., Fujita-Yamaguchi, Y
    • Journal Title

      BioScience Trends

      Volume: 9 Issue: 1 Pages: 49-55

    • DOI

      10.5582/bst.2014.01127

    • NAID

      130005054681

    • ISSN
      1881-7815, 1881-7823
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25830073, KAKENHI-PROJECT-15K08299, KAKENHI-PUBLICLY-15H01464
  • [Journal Article] Requirement of DLG1 for cardiovascular development and tissue elongation 1 during cochlear, enteric, and skeletal development: possible role in convergent extension.2015

    • Author(s)
      Akiko Iizuka-Kogo, Takao Senda, Tetsu Akiyama, Atsushi Shimomura, Ryuji Nomura, Yoshimi Hasegawa, Ken-ichi Yamamura, Hiroshi Kogo, Nobuhiko Sawai, Toshiyuki Matsuzaki
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 4 Pages: e0123965-e0123965

    • DOI

      10.1371/journal.pone.0123965

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-24590263, KAKENHI-PROJECT-24592567, KAKENHI-PROJECT-25460240, KAKENHI-PROJECT-221S0001
  • [Journal Article] Asef controls vascular endothelial permeability and barrier recovery in the lung.2015

    • Author(s)
      Tian X, Tian Y, Gawlak G, Meng F, Kawasaki Y, Akiyama T, Birukova AA.
    • Journal Title

      Mol Biol Cell.

      Volume: 26 Issue: 4 Pages: 636-650

    • DOI

      10.1091/mbc.e14-02-0725

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25290043
  • [Journal Article] Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.2015

    • Author(s)
      Taki Sakai, Yotaro Matsumoto, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto, Nobuhiko Wakai, Akio Kitao, Era Morishita, Chikashi Toyoshima, Tomoatsu Hayashi, Tetsu Akiyama
    • Journal Title

      Bioorg Med Chem.

      Volume: 23 Issue: 2 Pages: 328-339

    • DOI

      10.1016/j.bmc.2014.11.027

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-23370066, KAKENHI-PROJECT-24590136, KAKENHI-PLANNED-25104002, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
  • [Journal Article] HGF-induced Asef-IQGAP1 Complex Controls Cytoskeletal Remodeling and Endothelial Barrier.2015

    • Author(s)
      Tian Y, Gawlak G, Shah AS, Higginbotham K, Tian X, Kawasaki Y, Akiyama T, Sacks DB, Birukova AA.
    • Journal Title

      J Biol Chem.

      Volume: 290 Issue: 7 Pages: 4097-4109

    • DOI

      10.1074/jbc.m114.620377

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25290043
  • [Journal Article] Somatic copy number alterations associated with Japanese or endometriosis in ovarian clear cell adenocarcinoma.2015

    • Author(s)
      Okamoto A, Sehouli J, Yanaihara N, Hirata Y, Braicu I, Kim BG, Takakura S, Saito M, Yanagida S, Takenaka M, Yamaguchi N, Morikawa A, Tanabe H, Yamada K, Yoshihara K, Enomoto T, Itamochi H, Kigawa J, Matsumura N, Konishi I, Aida S, Aoki Y, Ishii N, Ochiai K, Akiyama T, Urashima M.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 2 Pages: 1-13

    • DOI

      10.1371/journal.pone.0116977

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25293338
  • [Journal Article] Heterogeneous nuclear ribonucleoprotein K upregulates the kinetochore complex component NUF2 and promotes the tumorigenicity of colon cancer cells2015

    • Author(s)
      Hironobu Sugimasa, Kenzui Taniue, Akiko Kurimoto, Yasuko Takeda, Yoshihiro Kawasaki, Tetsu Akiyama
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: Volume 459, Issue 1 Issue: 1 Pages: 29-35

    • DOI

      10.1016/j.bbrc.2015.02.043

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-13J10303, KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25830073, KAKENHI-PROJECT-15K08299, KAKENHI-PUBLICLY-15H01464, KAKENHI-PROJECT-25290043
  • [Journal Article] Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia2014

    • Author(s)
      Takanori Onouchi, Katsunori Kobayashi, Kazuyoshi Sakai, Atsushi Shimomura, Ron Smits, Chiho Sumi-Ichinose, Masafumi Kurosumi Keizo Takao, Ryuji Nomura, Akiko Iizuka-Kogo, Hidenori Suzuki,Kazunao Kondo, Tetsu Akiyama Tsuyoshi Miyakawa Riccardo Fodde and Takao Senda, Riccardo Fodde, Takao
    • Journal Title

      Molecular Brain

      Volume: 7 Issue: 1 Pages: 21-21

    • DOI

      10.1186/1756-6606-7-21

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PUBLICLY-24111546, KAKENHI-PROJECT-24590234, KAKENHI-PROJECT-24590264, KAKENHI-PROJECT-24592567, KAKENHI-PUBLICLY-25116525, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25242078, KAKENHI-PROJECT-25350989, KAKENHI-PROJECT-25460240, KAKENHI-PROJECT-25460345, KAKENHI-PROJECT-25460346, KAKENHI-PROJECT-25670138
  • [Journal Article] The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumorigenesis2014

    • Author(s)
      Tsuji S
    • Journal Title

      Nat. Commun.

      Volume: 5 Issue: 1 Pages: 3150-3150

    • DOI

      10.1038/ncomms4150

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112004, KAKENHI-PUBLICLY-24112506, KAKENHI-PROJECT-25290043, KAKENHI-PROJECT-25670138, KAKENHI-PROJECT-25830073
  • [Journal Article] Decreased apoptosis and persistence of the common nephric duct during the development of an aberrant vesicoureteral junction in dlg1 gene-targeted mice2013

    • Author(s)
      Akiko Iizuka-Kogo, Tetsu Akiyama, Takao Senda
    • Journal Title

      Anat Rec.

      Volume: 296 Issue: 12 Pages: 1936-1942

    • DOI

      10.1002/ar.22814

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25460240, KAKENHI-PROJECT-25670138
  • [Journal Article] Differences in the localization of the APC-Asef/Asef2 complex between APC wild-type and mutant cells2013

    • Author(s)
      Yoshihiro Kawasaki, Shiori Furukawa, Rina Sato, Tetsu Akiyama
    • Journal Title

      Cancer Sci.

      Volume: 8 Issue: 8 Pages: 1135-1138

    • DOI

      10.1111/cas.12180

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PUBLICLY-24112506, KAKENHI-PROJECT-25290043, KAKENHI-PROJECT-25670138
  • [Journal Article] Crystal structure of the guanylate kinase domain from Discs large homolog 1 (DLG1/SAP97)2013

    • Author(s)
      Shinji Mori, Yuta Tezuka, Akihiko Arakawa, Noriko Handa, Mikako Shirouzu, Tetsu Akiyama, Shigeyuki Yokoyama
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 435 Issue: 3 Pages: 334-338

    • DOI

      10.1016/j.bbrc.2013.04.056

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25670138
  • [Journal Article] Alendronate attenuates eosinophilic airway inflammation associated with suppression of Th2 cytokines, Th17 cytokines, and eotaxin-2.2013

    • Author(s)
      Oh Sasaki, Mitsuru Imamura, Yusuke Yamazumi, Hiroaki Harada, Taku Matsumoto, Katsuhide Okunishi, Kazuyuki Nakagome, Ryoichi Tanaka, Tetsu Akiyama, Kazuhiko Yamamoto and Makoto Dohi
    • Journal Title

      J. Immunol

      Volume: 191 Issue: 6 Pages: 2879-2889

    • DOI

      10.4049/jimmunol.1300460

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24890035, KAKENHI-PROJECT-25670138
  • [Journal Article] The miR-1-NOTCH3-Asef Pathway Is Important for Colorectal Tumor Cell Migration2013

    • Author(s)
      Shiori Furukawa,Yoshihiro Kawasaki, Masaya Miyamoto, Masaya Hiyoshi,Joji Kitayama, Tetsu Akiyama
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 11 Pages: e80609-e80609

    • DOI

      10.1371/journal.pone.0080609

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PUBLICLY-24112506, KAKENHI-PROJECT-25290043, KAKENHI-PROJECT-25670138
  • [Journal Article] ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma2013

    • Author(s)
      Yanagida S, Taniue K, Yamamoto T. (9名)
    • Journal Title

      Sci Rep

      Volume: Vol.3 Issue: 1 Pages: 1305-1305

    • DOI

      10.1038/srep01305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229006, KAKENHI-PLANNED-22112004, KAKENHI-PUBLICLY-25121734, KAKENHI-PROJECT-25830073, KAKENHI-ORGANIZER-22112001, KAKENHI-PUBLICLY-23121506
  • [Journal Article] Epub ahead of print2013

    • Author(s)
      Toki H, Inoue M, Motegi H, Minowa O, Kanda H, Yamamoto N, Ikeda A, Karashima Y, Matsui J, Kaneda H, Miura I, Suzuki T, Wakana S, Masuya H, Gondo Y, Shiroishi T, Akiyama T, Yao R, Noda T
    • Journal Title

      Cancer Sci

      Volume: PMID: 23551873 Issue: 7 Pages: 937-944

    • DOI

      10.1111/cas.12161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240043, KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-22500397, KAKENHI-PROJECT-23300161, KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25670138, KAKENHI-PROJECT-221S0001
  • [Journal Article] A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis.2011

    • Author(s)
      Taniue K. et al.
    • Journal Title

      EMBO Rep.

      Volume: 12 Issue: 7 Pages: 682-689

    • DOI

      10.1038/embor.2011.81

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21115004, KAKENHI-PROJECT-21390075, KAKENHI-ORGANIZER-22112001
  • [Journal Article] Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of sam682011

    • Author(s)
      Morishita EC, Murayama K, Kato-Murayama M, Ishizuka-Katsura Y, Tomabechi Y, Hayashi T, Terada T, Handa N, Shirouzu M, Akiyama T, Yokoyama S
    • Journal Title

      Structure

      Volume: 19 Issue: 10 Pages: 1496-1508

    • DOI

      10.1016/j.str.2011.07.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway2011

    • Author(s)
      Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A,Aburatani H, Nakamura T, Akiyama T
    • Journal Title

      Nat Commun

      Volume: 2 Issue: 1 Pages: 548-548

    • DOI

      10.1038/ncomms1551

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20221009, KAKENHI-PROJECT-21390075, KAKENHI-PROJECT-21590301, KAKENHI-PLANNED-22112004
  • [Journal Article] The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis.2010

    • Author(s)
      Kawasaki Y., Jigami T., Furukawa S., Sagara M., Echizen K., Shibata Y., Sato R., Akiyama T.
    • Journal Title

      J Biol Chem. 285

      Pages: 1199-207

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] Involvement of LKB1 in Epithelial-Mesenchymal Transition(EMT) of Human Lung Cancer Cells2010

    • Author(s)
      Roy BC, Kohno T, Iwakawa R, Moriguchi T, Kiyono T, Morishita K, Sanchez-Cespedes M, Akiyama T, Yokota J
    • Journal Title

      Lung Cancer

      Volume: 70 Issue: 2 Pages: 136-145

    • DOI

      10.1016/j.lungcan.2010.02.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] Sunspot, a link between Wingless signaling and endoreplication in Drosophila.2010

    • Author(s)
      Taniue K., Nishida A., Hamada F., Sugie A., Oda T., Ui-Tei K., Tabata T., Akiyama T.
    • Journal Title

      Development 137

      Pages: 1755-1764

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis2010

    • Author(s)
      Kawasaki Y, Jigami T, Furukawa S, Sagara M, Echizen K, Shibata Y, Sato R, Akiyama T
    • Journal Title

      J Biol Chem

      Volume: 285 Issue: 2 Pages: 1199-1207

    • DOI

      10.1074/jbc.m109.040691

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] Sunspot, a link between Wingless signaling and endoreplication in Drosophila2010

    • Author(s)
      Taniue K, Nishida A, Hamada F, Sugie A, Oda T, Ui-Tei K, Tabata T, Akiyama T
    • Journal Title

      Development

      Volume: 137 Issue: 10 Pages: 1755-1764

    • DOI

      10.1242/dev.042077

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] Sunspot, a link between Wingless signaling and endoreplication in Drosophila.2010

    • Author(s)
      Taniue K, Akiyama T, et al.
    • Journal Title

      Development

      Volume: 137 Pages: 1755-1764

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22112001
  • [Journal Article] The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas2010

    • Author(s)
      Niimi R, Matsumine A, Iino T, Murata T, Shintani K, Nakazora S, Nakamura T, Uehara Y, Kusuzaki K, Akiyama T, Uchida A
    • Journal Title

      Oncol Rep

      Volume: 23 Issue: 3 Pages: 631-638

    • DOI

      10.3892/or_00000678

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] High Expression of Pitx-2 in the ICAT-deficient Metanephros Leads to Developmental Arrest2010

    • Author(s)
      Hasegarwa, Y, Iizuka-Kogo, A, Akiyama, T, Senda T
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 43 Issue: 2 Pages: 51-59

    • DOI

      10.1267/ahc.09028

    • NAID

      130000248642

    • ISSN
      0044-5991, 1347-5800
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in ApcMin/+ mice.2009

    • Author(s)
      Kawasaki Y, Tsuji S, Muroya K, Furukawa S, Shibata Y, Okuno M, Ohwada S, Akiyama T.
    • Journal Title

      EMBO Rep. 10(12)

      Pages: 1355-1362

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16060101
  • [Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.2009

    • Author(s)
      Sagara M., Kawasaki Y., Iemura S., Natsume T., Takai Y., Akiyama T.
    • Journal Title

      Oncogene 28

      Pages: 1357-1365

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] APC and Asef function downstream of the HGF receptor and phosphatidylinositol 3-kinase2009

    • Author(s)
      Kawasaki Y, Tsuji S, Sagara M, Echizen K, Shibata Y, Akiyama T
    • Journal Title

      J Biol Chem

      Volume: 284 Issue: 33 Pages: 22436-22443

    • DOI

      10.1074/jbc.m109.020768

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration2009

    • Author(s)
      Sagara M. , Kawasaki Y. , Iemura S. I., Natsume T., Takai Y., Akiyama T.
    • Journal Title

      Oncogene 28

      Pages: 1357-1365

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Gene set-based module discovery in the breast cancer transcriptome2009

    • Author(s)
      Niida A., Smith A. D., Imoto S., Aburatani H.,Zhang M. Q. and Akiyama T.
    • Journal Title

      BMC Bioinformatics 10

      Pages: 71-71

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] APC and Asef function downstream of the HGF receptor and phosphatidylinositol 3-kinase.2009

    • Author(s)
      Kawasaki Y., Tsuji S., Sagara M., Echizen K., Shibata Y., Akiyama T.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 22436-22443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes2009

    • Author(s)
      Yamazumi Y, Kamiya A, Nishida A, Nishihara A, Iemura S, Natsume T, Akiyama T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 389 Issue: 1 Pages: 100-104

    • DOI

      10.1016/j.bbrc.2009.08.096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] The APC-associated exchange factors Asef and Asef2 are required for adenoma formation in ApcMin/+ mice.2009

    • Author(s)
      Kawasaki Y., Tsuji S., Muroya K., Furukawa S., Shibata Y., Okuno M., Ohwada S., Akiyama T.
    • Journal Title

      EMBO Rep. 10

      Pages: 1355-1362

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] Gene set-based module discovery in the breast cancer transcriptome2009

    • Author(s)
      Niida A, Smith AD, Imoto S, Aburatani H, Zhang MQ, Akiyama T
    • Journal Title

      BMC Bioinformatics

      Volume: 10 Issue: 1 Pages: 71-71

    • DOI

      10.1186/1471-2105-10-71

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+mice with natural ligands2009

    • Author(s)
      Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, Pettersson S, Pollenz RS, Sakaki T, Hirokawa T, Akiyama T, Kurosumi M, Poellinger L, Kato S, Fujii-Kuriyama Y
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 106 Issue: 32 Pages: 13481-13486

    • DOI

      10.1073/pnas.0902132106

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] The APC-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc^<Min/+> mice2009

    • Author(s)
      Kawasaki Y, Tsuji S, Muroya K, Furukawa S, Shibata Y, Okuno M, Ohwada S, Akiyama T
    • Journal Title

      EMBO Rep

      Volume: 10 Issue: 12 Pages: 1355-1362

    • DOI

      10.1038/embor.2009.233

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration2009

    • Author(s)
      Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T
    • Journal Title

      Oncogene

      Volume: 28 Issue: 10 Pages: 1357-1365

    • DOI

      10.1038/onc.2008.478

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Journal Article] PX-RICS mediates ER-to-Golgi transport of the N-cadherin/β-catenin complex2008

    • Author(s)
      Nakamura T., Hayashi T., Yukiko Nasu-Nishimura Y., Sakaue F., Okabe T., Ohwada S., Matsuura K., Akiyama T.
    • Journal Title

      Genes Dev 22

      Pages: 1244-1256

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] PX-RICS mediates ER-to-Golgi transport of the N-cadherin/ β-catenin complex.2008

    • Author(s)
      Nakamura T, Hayashi T, Nasu- Nishimura Y, Sakaue F, Morishita Y, Okabe T, Ohwada S, Matsuura K, Akiyama T.
    • Journal Title

      Genes Dev. 22(9)

      Pages: 1244-1256

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16060101
  • [Journal Article] Phosphorylation and activation of a Rac1/Cdc42 guanine nucleotide exchange factor Asef in A431 cells stimulated by epidermal growth factor2008

    • Author(s)
      Itoh, R. E., Kiyokawa, E., Aoki, K., Nishioka, T., Akiyama, T., Matsuda, M.
    • Journal Title

      J Cell Sci 121

      Pages: 2635-2642

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer2008

    • Author(s)
      Togo N., Ohwada S., Sakurai S., Toya H., Sakamoto I., Yamada T., Nakano T., Muroya K., Takeyoshi I., Nakajima T., Sekiya T., Yamazumi Y., Nakamura T., Akiyama T.
    • Journal Title

      World J. Gastroenterol 14

      Pages: 4880-4888

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli2008

    • Author(s)
      Kouzmenko A. P., Takeyama K., Kawasaki Y., Akiyama T., Kato S.
    • Journal Title

      Oncogene 27

      Pages: 4888-4899

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] A human homolog of Notum, over-expressed in hepatocellular carcinoma, is transcriptionally regulated by β-catenin/TCF2008

    • Author(s)
      Torisu, Y., Watanabe, A., Nonaka, A., Midorikawa, Y., Makuuchi, M., Shimamura, T., Sugimura, H., Niida, A., Akiyama, T., Iwanari, H., Kodama, T., Zeniya, M., Aburatani, H.
    • Journal Title

      Cancer Sci 99

      Pages: 1139-1146

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3β-mediated phosphorylation of β-catenin2008

    • Author(s)
      Haraguchi K., Ohsugi M., Abe Y., Semba K., Akiyama T., Yamamoto T.
    • Journal Title

      Oncogene 27

      Pages: 274-284

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Ligand-dependent interaction between estrogen receptor alpha and adenomatous polyposis coli2008

    • Author(s)
      Kouzmenko, A. P., Takeyama, K. I., Kawasaki,Y., Akiyama, T., Kato, S.
    • Journal Title

      Genes Cells 13

      Pages: 723-730

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells2008

    • Author(s)
      Niida A., Smith A. D., Imoto S., Tsutsumi S., Aburatani H., Zhang M. Q., Akiyama T.
    • Journal Title

      BMC Bioinformatics 9

      Pages: 404-404

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] PX-RICS mediates ER-to-Golgi transport of the N-cadherin/-catenin complex.2008

    • Author(s)
      Nakamura T., Hayashi T., Nasu-Nishimura Y., Sakaue F., Okabe T., Ohwada S., Matsuura K., Akiyama T.
    • Journal Title

      Genes Dev. 22

      Pages: 1244-1256

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] Up-regulation of a BCL9-related beta-catenin-binding protein, B9L, in different stages of sporadic colorectal adenoma2007

    • Author(s)
      Sakamoto I., Ohwada S., Toya H., Togo N., Kashiwabara K., Oyama T., Nakajima T., Ito H., Adachi S., Jigami T., Akiyama T.
    • Journal Title

      Cancer Sci 98

      Pages: 83-87

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] PH-domain-mediated membrane targeting of Asef2007

    • Author(s)
      Muroya, K., Kawasaki, Y., Hayashi, T., Ohwada, S., Akiyama T.
    • Journal Title

      Biochem. Biophys. Res. Commun 355

      Pages: 85-88

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesis2007

    • Author(s)
      Hasegawa, Y., Satoh, K., Iizuka-Kogo, A., Shimomura, A., Nomura, R., Akiyama, T., Senda, T.
    • Journal Title

      Biochem. Biophys. Res. Commun 362

      Pages: 988-994

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Identification and Characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42.2007

    • Author(s)
      Kawasaki Y., Sagara M., Shibata S., Shirouzu M., Yokoyama S., Akiyama T.
    • Journal Title

      Oncogene 26

      Pages: 7620-7627

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development2007

    • Author(s)
      Hayashi T., Okabe T., Nasu-Nishimura Y., Sakaue F., Ohwada S., Matsuura K., Akiyama T., Nakamura T.
    • Journal Title

      Genes Cells 12

      Pages: 929-939

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Crystal structure of the rac activator, asef, reveals its autoinhibitory mechanism2007

    • Author(s)
      Murayama K., Shirouzu M., Kawasaki Y., Kato-Murayama M., Hanawa-Suetsugu K., Sakamoto A., Katsura Y., Suenaga A., Toyama M., Terada T., Taiji M., Akiyama T., Yokoyama S.
    • Journal Title

      J Biol Chem. 282

      Pages: 4238-4242

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells2007

    • Author(s)
      Murata-Kamiya, N., Kurashima, Y., Teishikata, Y., Yamahashi, Y., Saito, Y., Higashi, H., Aburatani, H., Akiyama, T., Peek Jr., R. M., Azuma, T., Hatakeyama, M.
    • Journal Title

      Oncogene 26

      Pages: 4617-4626

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] α-catenin is essential in intestinal adenoma formation2007

    • Author(s)
      Shibata, H., Takano, H., Ito, M., Shioya, H., Hirota, M., Matsumoto, H., Kakudo, Y., Ishioka, C., Akiyama, T., Kanegae, Y., Saito, I., Noda T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 104

      Pages: 18199-18204

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Requirement of the tumor suppressor APC for the clustering of PSD-95 and AMPA receptors in hippocampal neurons2007

    • Author(s)
      Shimomura A., Ohkuma M., Iizuka-Kogo A., Kohu K., Nomura R., Miyachi E., Akiyama T., Senda T.
    • Journal Title

      Eur. J. Neurosci 26

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Abnormal development of urogenital organs in Dlgh1-deficient mice2007

    • Author(s)
      Iizuka-Kogo A., Ishidao T., Akiyama T., Senda T.
    • Journal Title

      Development(equal corresponding authors) 134

      Pages: 1799-1807

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Novel clusters of highly expressed genes accompany genomic amplification in breast cancers2007

    • Author(s)
      Ito E., Honma R., Yanagisawa Y., Imai JI., Azuma S., Oyama T., Ohwada S., Akiyama T., Nomura N., Inoue JI., Watanabe S, Semba K.
    • Journal Title

      FEBS Letters 581

      Pages: 3909-3914

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Immunohistochemical expression of the beta-catenin-interacting protein B9L is associated with histological high nuclear grade and immunohistochemical ErbB2/HER-2 expression in breast cancers2007

    • Author(s)
      Toya H., Oyama T., Ohwada S., Togo N., Sakamoto I., Horiguchi J., Koibuchi Y., Adachi S., Jigami T., Nakajima T., Akiyama T.
    • Journal Title

      Cancer Sci 98

      Pages: 484-490

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Identification and Characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc422007

    • Author(s)
      Kawasaki Y., Sagara M., Shibata S., Shirouzu M., Yokoyama S., Akiyama T.
    • Journal Title

      Oncogene 26

      Pages: 7620-7627

    • Data Source
      KAKENHI-PROJECT-19390082
  • [Journal Article] Wnt signaling and the tumor suppressor APC.2006

    • Author(s)
      Akiyama T.
    • Journal Title

      Recent Advances in Gastrointestinal Carcinogenesis

      Pages: 99-113

    • Data Source
      KAKENHI-PROJECT-17390089
  • [Journal Article] Wnt signaling and the tumor suppressor APC2006

    • Author(s)
      Akiyama, T.
    • Journal Title

      Recent Advances in Gastrointestinal Carcinogenesis

      Pages: 99-113

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390089
  • [Journal Article] Wnt signaling and the actin cytoskeleton.2006

    • Author(s)
      T. Akiyama, et. al.
    • Journal Title

      Oncogene 25

      Pages: 7538-7544

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390089
  • [Journal Article] Wnt signaling and the tumor suppressor APC.2006

    • Author(s)
      Akiyama T.
    • Journal Title

      Recent Advances in Gastrointestinal Carcinogenesis

      Pages: 99-113

    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] Wnt signaling and the actin cytoskeleton.2006

    • Author(s)
      Akiyama T.
    • Journal Title

      Oncogene 25

      Pages: 7538-7544

    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] Wnt signaling and the actin cytoskeleton.2006

    • Author(s)
      Akiyama T.
    • Journal Title

      Oncogene 25

      Pages: 7538-7544

    • Data Source
      KAKENHI-PROJECT-17390089
  • [Journal Article] The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6 and Ldbl.2006

    • Author(s)
      T. Akiyama, et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 343

      Pages: 1186-1190

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390089
  • [Journal Article] Wnt signalling and the actin cytoskeleton.2006

    • Author(s)
      Akiyama, T.
    • Journal Title

      Oncogene 25・57

      Pages: 7538-7544

    • Data Source
      KAKENHI-PROJECT-16060101
  • [Journal Article] Role of the kinesin-2 family protein, KIF3, during mitosis.2006

    • Author(s)
      Haraguchi K., Hayashi T., Jimbo T., Yamamoto T., Akiyama T.
    • Journal Title

      J Biol. Chem. 281

      Pages: 4094-4099

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] Wnt signaling and the actin cytoskeleton2006

    • Author(s)
      Akiyama, T.
    • Journal Title

      Oncogene 25

      Pages: 7538-7544

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390089
  • [Journal Article] Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells.2004

    • Author(s)
      Akiyama, S., Yonezawa, T., Kudo, T., Li, M. G., Wang, H., Ito, M., Yoshioka, K., Ninomiya-Tsuji, J., Matsumoto, K., Kanamaru, R., ^*Tamura, S., ^*Kobayashi, T.
    • Journal Title

      J. Biol. Chem. 279

      Pages: 36616-36620

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14086101
  • [Journal Article] Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells.2004

    • Author(s)
      Akiyama, Shoko
    • Journal Title

      The Journal of Biological Chemistry 279

      Pages: 36616-36620

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14086101
  • [Journal Article] Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells2004

    • Author(s)
      Akiyama, Shoko
    • Journal Title

      Journal of Biological Chemistry 279

      Pages: 36616-36620

    • Data Source
      KAKENHI-PROJECT-14086101
  • [Journal Article] Wnt signaling and the tumor suppressor APC.

    • Author(s)
      T.Akiyama.
    • Journal Title

      Recent Advances in Gastrointestinal Carcinogenesis. (in press)

    • Data Source
      KAKENHI-PROJECT-17390089
  • [Journal Article] The PX-RICS/14-3-3ζ/θcomplex couples N-cadherin/ β-catenin with dynein/dynactin to mediate its export from the endoplasmic reticulum.

    • Author(s)
      Nakamura T., Hayashi T., Mimori-Kiyosue Y., Sakaue F., Matsuura K., Imura S., Natsume T., T. Akiyama.
    • Journal Title

      J. Biol. Chem. (in press)

    • Data Source
      KAKENHI-PROJECT-17014011
  • [Journal Article] Wnt signaling and the tumor suppressor APC.

    • Author(s)
      T.Akiyama
    • Journal Title

      Recent Advances in Gastrointestinal Carcinogenesis. (in press.)

    • Data Source
      KAKENHI-PROJECT-17014011
  • [Patent] すい臓がん、非小細胞肺がん、大腸がん及び胆管がんよりなる群から選択される少なくとも1種のがんの予防又は治療剤、該剤を含む組み合わせ医療、並びに、がんの予防又は治療剤をスクリーニングする方法2020

    • Inventor(s)
      秋山 徹 他
    • Industrial Property Rights Holder
      秋山 徹 他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-081351
    • Filing Date
      2020
    • Data Source
      KAKENHI-PLANNED-17H06325
  • [Patent] 延寿命制御活性を有する物質をスクリーニングする方法2013

    • Inventor(s)
      秋山徹 他3名
    • Industrial Property Rights Holder
      秋山徹 他3名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-24
    • Data Source
      KAKENHI-PROJECT-25670138
  • [Patent] アポトーシス誘導遺伝子およびその利用2010

    • Inventor(s)
      秋山徹
    • Industrial Property Rights Holder
      秋山徹, 大正製薬株式会社
    • Acquisition Date
      2010-03-10
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Patent] 大腸癌抑制遺伝子関連蛋白質2009

    • Inventor(s)
      秋山徹, 川崎善博
    • Industrial Property Rights Holder
      第一三共株式会社
    • Filing Date
      2009-09-10
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Patent] アポトーシス誘導遺伝子およびその利用2009

    • Inventor(s)
      秋山徹、廣子貴俊
    • Industrial Property Rights Holder
      大正製薬株式会社、秋山徹
    • Acquisition Date
      2009-12-25
    • Data Source
      KAKENHI-PROJECT-16060101
  • [Patent] アポトーシス誘導遺伝子およびその利用2004

    • Inventor(s)
      秋山徹、廣子貴俊
    • Industrial Property Rights Holder
      大正製薬株式会社、秋山徹
    • Filing Date
      2004-02-10
    • Data Source
      KAKENHI-PROJECT-16060101
  • [Presentation] がん幹細胞を標的としたSIRT2阻害剤の開発2019

    • Author(s)
      林 寛敦、秋山 徹
    • Organizer
      第23回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PLANNED-17H06325
  • [Presentation] 1細胞シーケンス解析による腫瘍内不均一性の理解に向けた取り組み2019

    • Author(s)
      林 寛敦、秋山 徹
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PLANNED-17H06325
  • [Presentation] 数理科学的手法を取り入れた1細胞RNA-seqデータの統合的解析への取り組み2018

    • Author(s)
      林 寛敦、川崎 秀二、仲嶋 なつ、中戸 隆一郎、秋山 徹
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PLANNED-17H06325
  • [Presentation] 数理科学的手法を取り入れた1細胞RNA-seqデータの統合的解析への取り組み2018

    • Author(s)
      秋山 徹、林 寛敦、川崎 秀二、仲嶋 なつ、中戸 隆一郎
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17H01537
  • [Presentation] がん組織とがん幹細胞の分化モデルを用いた1細胞RNA-seq解析2018

    • Author(s)
      林 寛敦、秋山徹
    • Organizer
      新学術領域研究「細胞社会ダイバーシティーの統合的解明と制御」 第一回公開シンポジウム
    • Data Source
      KAKENHI-PLANNED-17H06325
  • [Presentation] がん組織とがん幹細胞の分化モデルを用いた1細胞RNA-seq解析2018

    • Author(s)
      秋山 徹、林 寛敦
    • Organizer
      新学術領域研究「細胞社会ダイバーシティーの統合的解明と制御」 若手ワークショップ
    • Data Source
      KAKENHI-PROJECT-17H01537
  • [Presentation] がん組織とがん幹細胞の分化モデルを用いた1細胞RNA-seq解析2018

    • Author(s)
      林 寛敦、秋山徹
    • Organizer
      新学術領域研究「細胞社会ダイバーシティーの統合的解明と制御」 若手ワークショップ
    • Data Source
      KAKENHI-PLANNED-17H06325
  • [Presentation] がん組織とがん幹細胞の分化モデルを用いた1細胞RNA-seq解析2018

    • Author(s)
      秋山 徹、林 寛敦
    • Organizer
      新学術領域研究「細胞社会ダイバーシティーの統合的解明と制御」 第一回公開シンポジウム
    • Data Source
      KAKENHI-PROJECT-17H01537
  • [Presentation] 新規 lncRNA :CASCA はAXL の発現を誘導して大腸がん細胞の運動や薬剤耐性を促進する2017

    • Author(s)
      川崎 善博、宮本 昌弥、須田 咲希子、秋山 徹
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PLANNED-17H06325
  • [Presentation] がん幹細胞を標的とした分子標的薬の開発2017

    • Author(s)
      林 寛敦、秋山徹
    • Organizer
      第76回日本癌学会学術総会 コアシンポジウム「新たなステージに入ったがん幹細胞研究」
    • Data Source
      KAKENHI-PLANNED-17H06325
  • [Presentation] 新規 lncRNA :CASCA はAXL の発現を誘導して大腸がん細胞の運動や薬剤耐性を促進する2017

    • Author(s)
      秋山 徹、川崎 善博、宮本 昌弥、須田 咲希子
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H01537
  • [Presentation] がん幹細胞を標的とした分子標的薬の開発2017

    • Author(s)
      秋山 徹、林 寛敦
    • Organizer
      第76回日本癌学会学術総会 コアシンポジウム「新たなステージに入ったがん幹細胞研究」
    • Data Source
      KAKENHI-PROJECT-17H01537
  • [Presentation] SIRT2,a promising molecular target for glioblastoma therapy2013

    • Author(s)
      Kanae Echizen, Kosuke Funato, Yukiko Nasu-Nishimura, Ryo Koyama-Nasu, Tomoki Todo, Yasushi Ino, Nobuhito Saito, Tetsu Akiyama
    • Organizer
      第9回日米合同癌学会
    • Place of Presentation
      ハイアット リージェンシー、マウイ
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] The miR-1-Notch3-Asef pathway is important for colorectal tumor cell migration2013

    • Author(s)
      Shiori Furukawa, Yoshihiro Kawasaki, Masaya Hiyoshi, Joji Kitayama, Tetsu Akiyama
    • Organizer
      第9回日米合同癌学会
    • Place of Presentation
      ハイアット リージェンシー、マウイ
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] Role of 5-hydroxymethylcytosine in the tumorigenicity of glioblastoma cells2013

    • Author(s)
      Hiroki Takai, Tetsu Akiyama
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-22112001
  • [Presentation] The cancer stem cell marker CD133 is required for desmosome formation2012

    • Author(s)
      那須 亮、髙橋 理那、柳田 聡、西村 教子、尾山 大明、秦 裕子、春田 諒、眞鍋 瑛美、大久保 明美、尾見 裕子、矢内原 臨、岡本 愛光、田中 忠男、秋山 徹
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] 大腸がんの造腫瘍性に関与する新規long ncRNAの機能解析2012

    • Author(s)
      谷上 賢瑞, 栗本 晶子, 杉政 宏信, 長嶋 剛史, 岡田 眞里子, 秋山 徹
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] Regulation of cell fusion through Wnt signaling~Novel insight into cell fusion biology~2012

    • Author(s)
      松浦 憲、地神貴史、谷上賢瑞、森下保幸、足達俊吾、千田隆夫、野中 綾、油谷浩幸、中村 勉、秋山 徹
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] Identification of a link between Wnt / β-catenin signaling and the cell fusion pathwa2012

    • Author(s)
      Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T.
    • Organizer
      EMBO Conference 30 Years of Wnt Signaling
    • Place of Presentation
      オランダ
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] miR-1-Notch3-Asef経路は大腸癌細胞の運動 能亢進に重要である2012

    • Author(s)
      川崎 善博, 古川 史織, 秋山 徹
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      ロイトン札幌
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] The SOX2-pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells2012

    • Author(s)
      那須 亮、春田 諒、西村 教子、谷上 賢端、加藤 由起、白髭 克彦、藤堂 具紀、稲生 靖、武笠 晃丈、齊藤 延人、松井 真弓、髙橋 理那、大久保 明美、菅野 陽元、真鍋瑛美、船戸 洸佑、秋山 徹
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] 膠芽腫幹細胞におけるcyclin D2の重要な役割(English workshop)2010

    • Author(s)
      那須亮、秋山徹, ほか
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際コンベンションセンター(大阪府大阪市)
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-ORGANIZER-22112001
  • [Presentation] PX-RICS/14-3-3ζ/θ複合体はN-cadherin/β-catenin複合体とdynein/dynactin複合体をリンクしその小胞体輸出を制御する2010

    • Author(s)
      中村勉,林寛敦,清末優子,坂上史佳,松浦憲,家村俊一郎,夏目徹,秋山徹
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Presentation] PX-RICS/14-3-3ζ/θ複合体はN-cadherin/β-catenin複合体とdynein/dynactin複合体をリンクしその小胞体輸出を制御する2010

    • Author(s)
      中村勉,林寛敦,清末優子,坂上史佳,松浦憲,家村俊一郎,夏目徹,秋山徹
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Presentation] Wnt/β-cateninシグナルが細胞融合シグナルを制御する新規シグナル伝達経路の同定2010

    • Author(s)
      松浦憲,地神貴史,谷上賢瑞,森下保幸,足達俊吾,千田隆夫,油谷浩幸,中村勉,秋山徹
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef/Asef2 in intestinal adenoma formation2009

    • Author(s)
      川崎善博, 辻真之介, 室谷研, 古川史織大和田進, 秋山徹
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef/Asef2 in intestinal adenoma formation2009

    • Author(s)
      川崎善博, 辻真之介, 室谷研, 古川史織, 大和田進, 秋山徹
    • Organizer
      分子生物学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Presentation] PX-RICSはN-cadherin/β-catenin複合体の小胞体-ゴルジ体輸送を制御する.ミニシンポジウム(細胞間接着研究の新展開)2009

    • Author(s)
      中村勉,林寛敦,那須-西村教子,坂上史佳,森下保幸,夏目徹,松浦憲,秋山徹
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-06-03
    • Data Source
      KAKENHI-PROJECT-21390075
  • [Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef in signal transduction and angiogenesis2008

    • Author(s)
      川崎善博, 地神貴史, 古川史織, 相良将樹, 柴田葉子, 佐藤梨奈, 秋山徹
    • Organizer
      分子生物学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Presentation] Role of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc422008

    • Author(s)
      相良将樹, 川崎善博, 秋山徹
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Presentation] 癌抑制遺伝子apcの機能2008

    • Author(s)
      秋山徹
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-16060101
  • [Presentation] 癌抑制遺伝子APCの機能2008

    • Author(s)
      秋山徹
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-16060101
  • [Presentation] 癌抑制遺伝子APCの機能2007

    • Author(s)
      秋山 徹
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-16060101
  • [Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef in intestinal adenoma formation, dentification and Characterization of2007

    • Author(s)
      辻真之介, 川崎善博, 秋山徹, 相良将樹, 川崎善博, 秋山徹
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17014011
  • [Presentation] 5-Hydroxymethylcytosine Plays a Critical Role in Glioblastomagenesis by Recruiting the CHTOP-Methylosome Complex

    • Author(s)
      Hiroki Takai, Tetsu Akiyama
    • Organizer
      Keystone Symposia: Epigenetics and Cancer
    • Place of Presentation
      Colorado, USA
    • Year and Date
      2015-01-25 – 2015-01-30
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] The role of miR-363-GATA6-Lgr5 pathway in colorectal tumorigenesis

    • Author(s)
      川崎 善博、辻 真之介、古川 史織、谷上 賢瑞、林 寛敦、日吉 雅也 、北山 丈二 、秋山 徹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-03 – 2013-10-05
    • Data Source
      KAKENHI-PROJECT-25670138
  • [Presentation] ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma.

    • Author(s)
      谷上 賢瑞、秋山 徹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-03 – 2013-10-05
    • Data Source
      KAKENHI-PROJECT-25670138
  • [Presentation] Functional analysis of a novel long ncRNA involved in the tumorigenicity of colorectal cancer.

    • Author(s)
      Kenzui Taniue,Akiko Kurimoto,Hironobu Sugimasa, Emiko Nasu, Takeshi Nagashima,Mariko Okada-Hatakeyama,Tetsu Akiyama
    • Organizer
      AACR
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2013-04-06 – 2013-04-10
    • Data Source
      KAKENHI-PROJECT-25670138
  • [Presentation] 神経膠芽腫の発症における5-hydroxymethylcytosineの役割 / Role of 5-hydroxymethylcytosine in the tumorigenicity of glioblastoma cells

    • Author(s)
      高井 弘基、秋山 徹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-10-03 – 2013-10-05
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] 5hmC plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex

    • Author(s)
      高井 弘基、秋山 徹
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] MYU, a novel target lncRNA for Wnt/c-Myc signaling, mediates CDK6 induction to promote cell cycle progression

    • Author(s)
      Yoshihiro Kawasaki, Tetsu Akiyama
    • Organizer
      Joint International Symposium on TGF-β Family and Cancer: TGF-β Family and Cancer: Signal Network in Tumor Micoroenvironment
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2015-01-12 – 2015-01-13
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] ”Long non-coding RNA ASBEL required for tumorigenicity of colon cancer

    • Author(s)
      Kenzui Taniue, Tetsu Akiyama
    • Organizer
      Long Noncoding RNAs: Marching toward Mechanism
    • Place of Presentation
      Santa Fe, New Mexico, USA
    • Year and Date
      2014-02-27 – 2014-03-04
    • Data Source
      KAKENHI-PROJECT-25670138
  • [Presentation] 神経膠芽腫の発症における5-hydroxymethylcytosineの役割 / Role of 5-hydroxymethylcytosine in the tumorigenicity of glioblastoma cells

    • Author(s)
      高井 弘基、秋山 徹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-03 – 2013-10-05
    • Data Source
      KAKENHI-PROJECT-25670138
  • [Presentation] TET1 as a molecular target for glioblastoma therapy (神経膠芽腫治療の標的としてのTET1)

    • Author(s)
      高井 弘基、秋山 徹
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] Functional analysis of a novel long ncRNA involved in the tumorigenicity of colorectal cancer

    • Author(s)
      Kenzui Taniue,Akiko Kurimoto,Hironobu Sugimasa, Emiko Nasu, Takeshi Nagashima,Mariko Okada-Hatakeyama,Tetsu Akiyama
    • Organizer
      AACR
    • Place of Presentation
      アメリカ合衆国ワシントンDC
    • Year and Date
      2013-04-06 – 2013-04-10
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] GATA6を介した細胞癌化におけるReg4とLgr5の協調作用

    • Author(s)
      川崎善博、辻真之介、宮本昌弥、平岡巧士、松村厚佑、奥野ます美、須田咲希子、日吉雅也、北山丈二、秋山徹
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] The role of miR-363-GATA6-Lgr5 pathway in colorectal tumorigenesis

    • Author(s)
      川崎 善博、辻 真之介、古川 史織、谷上 賢瑞、林 寛敦、日吉 雅也 、北山 丈二 、秋山 徹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-10-03 – 2013-10-05
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] RNA結合タンパク質D8はc-junの転写後制御を介してAPC (Min/+)マウスにおける腫瘍形成を制御する

    • Author(s)
      山角 祐介、渡邊 紘介、小田 健昭、佐藤 裕美、秋山 徹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-03 – 2013-10-05
    • Data Source
      KAKENHI-PROJECT-25670138
  • [Presentation] The role of the novel long non-coding RNA in human colorectal cancer stem cells

    • Author(s)
      松村厚佑、宮本昌弥、川崎善博、斉藤晋祐、日吉雅也、北山丈二、秋山徹
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma

    • Author(s)
      Kenzui Taniue, Satoshi Yanagida, Hironobu Sugimasa, Yasuko Takeda, Tadashi Yamamoto, Aikou Okamoto, Tetsu Akiyama
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] Long non-coding RNA ASBEL required for tumorigenicity of colon cancer

    • Author(s)
      Kenzui Taniue, Tetsu Akiyama
    • Organizer
      Long Noncoding RNAs: Marching toward Mechanism
    • Place of Presentation
      アメリカ合衆国サンタフェ
    • Year and Date
      2014-02-27 – 2014-03-04
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] 大腸がん幹細胞における新規長鎖非コードRNAの機能解析

    • Author(s)
      松村厚佑、宮本昌弥、川崎善博、斎藤晋祐、日吉雅也、北山丈二、秋山徹
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] Cooperation between Reg4 and Lgr5 in GATA6-mediated colorectal tumorigenesis

    • Author(s)
      川崎 善博、辻 真之介、宮本 昌也、平岡 巧士、松村 厚佑、奥 野 ます美、須田 咲希子、日吉 雅也、北山 丈二、秋山 徹
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] 大腸がんの造腫瘍性に関与する新規long ncRNA の機能解析

    • Author(s)
      谷上 賢瑞、秋山 徹
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] RNA結合タンパク質D8はc-junの転写後制御を介してAPC (Min/+)マウスにおける腫瘍形成を制御する

    • Author(s)
      山角 祐介、渡邊 紘介、小田 健昭、佐藤 裕美、秋山 徹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-10-03 – 2013-10-05
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] Mex-3B, an RNA-binding protein, regulates lung cancer cell migration

    • Author(s)
      Yusuke Yamazumi, Tetsu Akiyama
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PLANNED-22112004
  • [Presentation] ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma

    • Author(s)
      Kenzui Taniue, Tetsu Akiyama
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-10-03 – 2013-10-05
    • Data Source
      KAKENHI-PLANNED-22112004
  • []

  • []

  • []

  • []

  • 1.  YAMAMOTO Tadashi (40134621)
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